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INFORMATION
Documentation
Tutorial
General introduction
Tutorial
Workshop materials
Workshop manual (PDF)
Workshop manual (Word)
Workshop videos
FOR DEVELOPERS
Linking to GPCRdb
Web services
GPCRdb
Citing GPCRdb
Receptor page
SEQUENCES
Sequence alignments
Generic residue number tables
Genetic variants
Variation coverage
Receptor variants
Estimated economic burden
Isoforms
SEQUENCE ANALYSIS
Receptor similarity
BLAST (GPCRdb alignment)
BLAST (non-GPCRdb query)
Phylogenetic trees
Similarity matrix (all-to-all)
Site search (by seq. motif)
STRUCTURES
Structure coverage
Structures
Structure models
Structure model validation
STRUCTURE ANALYSIS
Structure comparison tool
Structure similarity trees
Structure superposition
Generic residue numbering (PDB)
STRUCTURE CONSTRUCTS
Construct/Experiment design
Construct alignments
Construct design tool
Experiment browser
Truncation/Fusion analysis
Truncation sites
Fusion sites
Loop deletions
Mutation analysis
Stabilising mutations
StabMutAnalyser
Mutation substitution matrix
DETERMINANTS & MUTATIONS
Sequence signature tool
State stabilizing mutation design
Drugs
&
ligands
LIGANDS & BIOACTIVITIES
Ligand coverage
Ligands (ChEMBL, GtP, Ki db)
Ligands (by receptor query)
Ligands (by ligand query)
ENDOGENOUS LIGANDS
Endogenous ligands (GtP)
DRUGS & AGENTS IN TRIAL
Drugs, targets
&
indications
Drug target tree
Drug statistics
LIGAND SITES
GPCR-ligand interactions
Site search
Site search (by seq. motif)
Site search (by ligand complex)
LIGAND SITE MUTATIONS
Mutation coverage
Mutations
Mutation design tool
By receptor name
By PDB id
Mutation data submission
GproteinDb
Citing GproteinDb
G protein page
COUPLINGS
Couplings
Datasets
Biosensors
COUPLING ANALYSIS
Coupling selectivity (tree)
Coupling selectivity (Venn)
SEQUENCES
Sequence alignments
Generic residue number tables
STRUCTURES
Structure coverage
Structures
Structure models
STRUCTURE ANALYSIS
Interface interactions & profiling
Structure superposition
DETERMINANTS & MUTATIONS
Coupling determinant mutation design
Interface mutations & chimeras
ArrestinDb
Citing ArrestinDb
Arrestin page
COUPLINGS
Couplings
COUPLING ANALYSIS
Coupling selectivity (tree)
Coupling selectivity (Venn)
SEQUENCES
Sequence alignments
Generic residue number tables
STRUCTURES
Structure coverage
Structures
STRUCTURE ANALYSIS
Interface interactions (single structure)
DETERMINANTS & MUTATIONS
Interface mutations
Biased Signaling Atlas
Citing Biased Signaling Atlas
GUIDELINES
Community guidelines paper
Reference ligand selection
Template to calculate ligand bias factors
BIASED LIGANDS (for transducer family)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
Ligand pathway profiles (Δlog(Tau/KA))
BIASED LIGANDS (for transducer subtype)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
Ligand pathway profiles (Δlog(Tau/KA))
PATHWAY-PREFERRING LIGANDS (for transducer family)
Pathway-preferring ligand coverage
Pathway-preferring ligands (pathway ∆Log/(Emax/EC50)
Ligand pathway preference rank orders (Δlog(Emax/EC50))
Ligand pathway profiles (Log(Emax/EC50))
Pathways
Pathway effects
DATA DEPOSITION
Data submission
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Data annotation
Database development
Scientific collaboration
Social media
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Please cite the main reference and the reference for the page that you are using.
Download
Excel (xlsx)
Alignment (fasta)
Spreadsheet (csv)
Residue number
Sequence-based ()
Structure-based (GPCRdb)
[Green monkey] Uncharacterized protein
[Horse] Uncharacterized protein
[Duckbill platypus] Uncharacterized protein
[African elephant] Uncharacterized protein
[Tasmanian devil] Uncharacterized protein
[Bovine] G(s) subunit alpha isoforms short
[Human] G(s) subunit alpha isoforms short
[Mouse] G(s) subunit alpha isoforms short
[Rat] G(s) subunit alpha isoforms short
[European domestic ferret] Uncharacterized protein
Residue number
Sequence-based ()
Structure-based (GPCRdb)
Seq consensus
Prop consensus
Length
RESIDUE PROPERTIES & LENGTH
Hydrophobic
HY
any
Hydrophobic
HY
4-5
Hydrophobic aliphatic
HA
any
Hydrophobic aliphatic
HA
1-2
Hydrophobic aliphatic
HA
2-3
Hydrophobic aliphatic
HA
3
Hydrophobic aliphatic
HA
3-4
Hydrophobic aliphatic [M]
M
4
Hydrophob al / α-H prop - very high [A]
A
1
Hydrophobic aliphatic [I]
I
Hydrophobic aliphatic [L]
L
Hydrophobic aliphatic [V]
V
Hydrophobic aromatic
HR
any
Hydrophobic aromatic
HR
4-5
Hydrophobic aromatic
HR
5
Hydrophobic aromatic
HR
5-6
Hydrophobic aromatic [W]
W
6
Hydropob ar / H-bonding [Y]
Y
Hydrophobic aromatic [F]
F
Hydrogen bonding (polar)
Hb
any
Hydrogen bonding
Hb
2
Hydrogen bonding
Hb
3
Hydrogen bonding [N]
N
Hydrogen bonding [Q]
Q
Hydrogen bonding [S]
S
Hydrogen bonding [T]
T
Hydrogen bonding uncharged
Hu
2-3
Hydrogen bonding uncharged
Hu
3-4
Hydrogen bond acceptor
Ha
2-3
Hydrogen bond acceptor
Ha
3
Hydrogen bond acceptor
Ha
3-4
Hydrogen bond acceptor
Ha
4
Hydrogen bond donor
Hd
4
Hydrogen bond donor
Hd
4-5
Hydrogen bond donor
Hd
5-6
Hydrogen bond donor
Hd
6
Charged
+-
any
Charged
+-
3-4
Charged
+-
4-5
Charged positive
+
any
Charged pos / H bond / Hphob ar [H]
H
4
Charged positive
+
4-5
Charged positive [K]
K
5
Charged positive
+
5-6
Charged positive [R]
R
6
Charged negative
-
any
Charged negative [D]
D
3
Charged negative [E]
E
4
Small
Sm
any
Small
Sm
0-1
Small
Sm
1-2
α-Helix propensity - high
αH
Hig
α-Helix propensity - low
αH
Min
α-Helix flexibility [G]
G
0
α-Helix kink [P]
P
2
Disulfide-forming (S-S) [C]
C
2
Gap (no amino acid)
-
RESIDUE Z-SCALES
Z1 (Lipophilicity)
Z2 (Steric properties)
Z3 (Electronic properties)
Z4 (PC1 several properties)
Z5 (PC2 several properties)
Residue number
Sequence-based ()
Structure-based (GPCRdb)
G.HN
G.hns1
G.S1
G.s1h1
G.H1
G.h1ha
H.HA
H.hahb
H.HB
H.hbhc
H.HC
H.hchd
H.HD
H.hdhe
H.HE
H.hehf
H.HF
G.hfs2
G.S2
G.s2s3
G.S3
G.s3h2
G.H2
G.h2s4
G.S4
G.s4h3
G.H3
G.h3s5
G.S5
G.s5hg
G.HG
G.hgh4
G.H4
G.h4s6
G.S6
G.s6h5
G.H5
HN.01
HN.02
HN.07
HN.08
HN.09
HN.10
HN.11
HN.22
HN.23
HN.24
HN.26
HN.27
HN.28
HN.29
HN.30
HN.31
HN.32
HN.33
HN.34
HN.35
HN.36
HN.37
HN.38
HN.39
HN.40
HN.41
HN.42
HN.43
HN.44
HN.45
HN.46
HN.47
HN.48
HN.49
HN.50
HN.51
HN.52
HN.53
hns1.01
hns1.02
hns1.03
S1.01
S1.02
S1.03
S1.04
S1.05
S1.06
S1.07
s1h1.01
s1h1.02
s1h1.03
s1h1.04
s1h1.05
s1h1.06
H1.01
H1.02
H1.03
H1.04
H1.05
H1.06
H1.07
H1.08
H1.09
H1.10
H1.11
H1.12
h1ha.01
h1ha.02
h1ha.03
h1ha.04
h1ha.05
h1ha.06
h1ha.07
h1ha.08
h1ha.09
h1ha.10
h1ha.11
h1ha.12
h1ha.13
h1ha.14
h1ha.15
h1ha.16
h1ha.17
h1ha.18
h1ha.19
h1ha.20
HA.01
HA.02
HA.03
HA.04
HA.05
HA.06
HA.07
HA.08
HA.09
HA.10
HA.11
HA.12
HA.13
HA.14
HA.15
HA.16
HA.17
HA.18
HA.19
HA.20
HA.21
HA.22
HA.23
HA.24
HA.25
HA.26
HA.27
HA.28
HA.29
hahb.01
hahb.02
hahb.03
hahb.04
hahb.05
hahb.06
hahb.07
hahb.08
hahb.09
HB.01
HB.02
HB.03
HB.04
HB.05
HB.06
HB.07
HB.08
HB.09
HB.10
HB.11
HB.12
HB.13
HB.14
hbhc.01
hbhc.02
hbhc.03
hbhc.04
hbhc.13
hbhc.14
hbhc.15
HC.01
HC.02
HC.03
HC.04
HC.05
HC.06
HC.07
HC.08
HC.09
HC.10
HC.11
HC.12
hchd.01
HD.01
HD.02
HD.03
HD.04
HD.05
HD.06
HD.07
HD.08
HD.09
HD.10
HD.11
HD.12
hdhe.01
hdhe.02
hdhe.03
hdhe.04
hdhe.05
HE.01
HE.02
HE.03
HE.04
HE.05
HE.06
HE.07
HE.08
HE.09
HE.10
HE.11
HE.12
HE.13
hehf.01
hehf.02
hehf.03
hehf.04
hehf.05
hehf.06
hehf.07
HF.01
HF.02
HF.03
HF.04
HF.05
HF.06
hfs2.01
hfs2.02
hfs2.03
hfs2.04
hfs2.05
hfs2.06
hfs2.07
S2.01
S2.02
S2.03
S2.04
S2.05
S2.06
S2.07
S2.08
s2s3.01
s2s3.02
S3.01
S3.02
S3.03
S3.04
S3.05
S3.06
S3.07
S3.08
s3h2.01
s3h2.02
s3h2.03
H2.01
H2.02
H2.03
H2.04
H2.05
H2.06
H2.07
H2.08
H2.09
H2.10
h2s4.01
h2s4.02
h2s4.03
h2s4.04
h2s4.05
S4.01
S4.02
S4.03
S4.04
S4.05
S4.06
S4.07
s4h3.01
s4h3.02
s4h3.03
s4h3.04
s4h3.05
s4h3.06
s4h3.07
s4h3.08
s4h3.09
s4h3.10
s4h3.11
s4h3.12
s4h3.13
s4h3.14
s4h3.15
H3.01
H3.02
H3.03
H3.04
H3.05
H3.06
H3.07
H3.08
H3.09
H3.10
H3.11
H3.12
H3.13
H3.14
H3.15
H3.16
H3.17
H3.18
h3s5.01
h3s5.02
h3s5.03
S5.01
S5.02
S5.03
S5.04
S5.05
S5.06
S5.07
s5hg.01
HG.01
HG.02
HG.03
HG.04
HG.05
HG.06
HG.07
HG.08
HG.09
HG.10
HG.11
HG.12
HG.13
HG.14
HG.15
HG.16
HG.17
hgh4.01
hgh4.02
hgh4.03
hgh4.04
hgh4.05
hgh4.06
hgh4.07
hgh4.08
hgh4.09
hgh4.10
hgh4.11
hgh4.12
hgh4.13
hgh4.14
hgh4.15
hgh4.16
hgh4.17
hgh4.18
hgh4.19
hgh4.20
hgh4.21
H4.01
H4.02
H4.03
H4.04
H4.05
H4.06
H4.07
H4.08
H4.10
H4.11
H4.12
H4.13
H4.14
H4.15
H4.16
H4.17
h4s6.01
h4s6.02
h4s6.03
h4s6.04
h4s6.08
h4s6.09
h4s6.10
h4s6.11
h4s6.12
h4s6.13
h4s6.20
S6.01
S6.02
S6.03
S6.04
S6.05
s6h5.01
s6h5.02
s6h5.03
s6h5.04
s6h5.05
H5.01
H5.02
H5.03
H5.04
H5.05
H5.06
H5.07
H5.08
H5.09
H5.10
H5.11
H5.12
H5.13
H5.14
H5.15
H5.16
H5.17
H5.18
H5.19
H5.20
H5.21
H5.22
H5.23
H5.24
H5.25
H5.26
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L
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HN.01
HN.02
HN.07
HN.08
HN.09
HN.10
HN.11
HN.22
HN.23
HN.24
HN.26
HN.27
HN.28
HN.29
HN.30
HN.31
HN.32
HN.33
HN.34
HN.35
HN.36
HN.37
HN.38
HN.39
HN.40
HN.41
HN.42
HN.43
HN.44
HN.45
HN.46
HN.47
HN.48
HN.49
HN.50
HN.51
HN.52
HN.53
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HA.01
HA.02
HA.03
HA.04
HA.05
HA.06
HA.07
HA.08
HA.09
HA.10
HA.11
HA.12
HA.13
HA.14
HA.15
HA.16
HA.17
HA.18
HA.19
HA.20
HA.21
HA.22
HA.23
HA.24
HA.25
HA.26
HA.27
HA.28
HA.29
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hahb.06
hahb.07
hahb.08
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HB.03
HB.04
HB.05
HB.06
HB.07
HB.08
HB.09
HB.10
HB.11
HB.12
HB.13
HB.14
hbhc.01
hbhc.02
hbhc.03
hbhc.04
hbhc.13
hbhc.14
hbhc.15
HC.01
HC.02
HC.03
HC.04
HC.05
HC.06
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HC.08
HC.09
HC.10
HC.11
HC.12
hchd.01
HD.01
HD.02
HD.03
HD.04
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HD.06
HD.07
HD.08
HD.09
HD.10
HD.11
HD.12
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hdhe.02
hdhe.03
hdhe.04
hdhe.05
HE.01
HE.02
HE.03
HE.04
HE.05
HE.06
HE.07
HE.08
HE.09
HE.10
HE.11
HE.12
HE.13
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hehf.02
hehf.03
hehf.04
hehf.05
hehf.06
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HF.01
HF.02
HF.03
HF.04
HF.05
HF.06
hfs2.01
hfs2.02
hfs2.03
hfs2.04
hfs2.05
hfs2.06
hfs2.07
S2.01
S2.02
S2.03
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S2.05
S2.06
S2.07
S2.08
s2s3.01
s2s3.02
S3.01
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S3.06
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H2.01
H2.02
H2.03
H2.04
H2.05
H2.06
H2.07
H2.08
H2.09
H2.10
h2s4.01
h2s4.02
h2s4.03
h2s4.04
h2s4.05
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H3.01
H3.02
H3.03
H3.04
H3.05
H3.06
H3.07
H3.08
H3.09
H3.10
H3.11
H3.12
H3.13
H3.14
H3.15
H3.16
H3.17
H3.18
h3s5.01
h3s5.02
h3s5.03
S5.01
S5.02
S5.03
S5.04
S5.05
S5.06
S5.07
s5hg.01
HG.01
HG.02
HG.03
HG.04
HG.05
HG.06
HG.07
HG.08
HG.09
HG.10
HG.11
HG.12
HG.13
HG.14
HG.15
HG.16
HG.17
hgh4.01
hgh4.02
hgh4.03
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hgh4.06
hgh4.07
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hgh4.09
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H4.01
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H4.10
H4.11
H4.12
H4.13
H4.14
H4.15
H4.16
H4.17
h4s6.01
h4s6.02
h4s6.03
h4s6.04
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h4s6.09
h4s6.10
h4s6.11
h4s6.12
h4s6.13
h4s6.20
S6.01
S6.02
S6.03
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s6h5.01
s6h5.02
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s6h5.04
s6h5.05
H5.01
H5.02
H5.03
H5.04
H5.05
H5.06
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H5.08
H5.09
H5.10
H5.11
H5.12
H5.13
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H5.15
H5.16
H5.17
H5.18
H5.19
H5.20
H5.21
H5.22
H5.23
H5.24
H5.25
H5.26
-
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2.1
-4.3
0.8
0.8
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2.1
3.1
2.4
2.3
0.8
3.1
4.0
1.8
3.5
3.1
3.1
3.1
2.3
0.2
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HN.01
HN.02
HN.07
HN.08
HN.09
HN.10
HN.11
HN.22
HN.23
HN.24
HN.26
HN.27
HN.28
HN.29
HN.30
HN.31
HN.32
HN.33
HN.34
HN.35
HN.36
HN.37
HN.38
HN.39
HN.40
HN.41
HN.42
HN.43
HN.44
HN.45
HN.46
HN.47
HN.48
HN.49
HN.50
HN.51
HN.52
HN.53
hns1.01
hns1.02
hns1.03
S1.01
S1.02
S1.03
S1.04
S1.05
S1.06
S1.07
s1h1.01
s1h1.02
s1h1.03
s1h1.04
s1h1.05
s1h1.06
H1.01
H1.02
H1.03
H1.04
H1.05
H1.06
H1.07
H1.08
H1.09
H1.10
H1.11
H1.12
h1ha.01
h1ha.02
h1ha.03
h1ha.04
h1ha.05
h1ha.06
h1ha.07
h1ha.08
h1ha.09
h1ha.10
h1ha.11
h1ha.12
h1ha.13
h1ha.14
h1ha.15
h1ha.16
h1ha.17
h1ha.18
h1ha.19
h1ha.20
HA.01
HA.02
HA.03
HA.04
HA.05
HA.06
HA.07
HA.08
HA.09
HA.10
HA.11
HA.12
HA.13
HA.14
HA.15
HA.16
HA.17
HA.18
HA.19
HA.20
HA.21
HA.22
HA.23
HA.24
HA.25
HA.26
HA.27
HA.28
HA.29
hahb.01
hahb.02
hahb.03
hahb.04
hahb.05
hahb.06
hahb.07
hahb.08
hahb.09
HB.01
HB.02
HB.03
HB.04
HB.05
HB.06
HB.07
HB.08
HB.09
HB.10
HB.11
HB.12
HB.13
HB.14
hbhc.01
hbhc.02
hbhc.03
hbhc.04
hbhc.13
hbhc.14
hbhc.15
HC.01
HC.02
HC.03
HC.04
HC.05
HC.06
HC.07
HC.08
HC.09
HC.10
HC.11
HC.12
hchd.01
HD.01
HD.02
HD.03
HD.04
HD.05
HD.06
HD.07
HD.08
HD.09
HD.10
HD.11
HD.12
hdhe.01
hdhe.02
hdhe.03
hdhe.04
hdhe.05
HE.01
HE.02
HE.03
HE.04
HE.05
HE.06
HE.07
HE.08
HE.09
HE.10
HE.11
HE.12
HE.13
hehf.01
hehf.02
hehf.03
hehf.04
hehf.05
hehf.06
hehf.07
HF.01
HF.02
HF.03
HF.04
HF.05
HF.06
hfs2.01
hfs2.02
hfs2.03
hfs2.04
hfs2.05
hfs2.06
hfs2.07
S2.01
S2.02
S2.03
S2.04
S2.05
S2.06
S2.07
S2.08
s2s3.01
s2s3.02
S3.01
S3.02
S3.03
S3.04
S3.05
S3.06
S3.07
S3.08
s3h2.01
s3h2.02
s3h2.03
H2.01
H2.02
H2.03
H2.04
H2.05
H2.06
H2.07
H2.08
H2.09
H2.10
h2s4.01
h2s4.02
h2s4.03
h2s4.04
h2s4.05
S4.01
S4.02
S4.03
S4.04
S4.05
S4.06
S4.07
s4h3.01
s4h3.02
s4h3.03
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s4h3.05
s4h3.06
s4h3.07
s4h3.08
s4h3.09
s4h3.10
s4h3.11
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s4h3.13
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s4h3.15
H3.01
H3.02
H3.03
H3.04
H3.05
H3.06
H3.07
H3.08
H3.09
H3.10
H3.11
H3.12
H3.13
H3.14
H3.15
H3.16
H3.17
H3.18
h3s5.01
h3s5.02
h3s5.03
S5.01
S5.02
S5.03
S5.04
S5.05
S5.06
S5.07
s5hg.01
HG.01
HG.02
HG.03
HG.04
HG.05
HG.06
HG.07
HG.08
HG.09
HG.10
HG.11
HG.12
HG.13
HG.14
HG.15
HG.16
HG.17
hgh4.01
hgh4.02
hgh4.03
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hgh4.05
hgh4.06
hgh4.07
hgh4.08
hgh4.09
hgh4.10
hgh4.11
hgh4.12
hgh4.13
hgh4.14
hgh4.15
hgh4.16
hgh4.17
hgh4.18
hgh4.19
hgh4.20
hgh4.21
H4.01
H4.02
H4.03
H4.04
H4.05
H4.06
H4.07
H4.08
H4.10
H4.11
H4.12
H4.13
H4.14
H4.15
H4.16
H4.17
h4s6.01
h4s6.02
h4s6.03
h4s6.04
h4s6.08
h4s6.09
h4s6.10
h4s6.11
h4s6.12
h4s6.13
h4s6.20
S6.01
S6.02
S6.03
S6.04
S6.05
s6h5.01
s6h5.02
s6h5.03
s6h5.04
s6h5.05
H5.01
H5.02
H5.03
H5.04
H5.05
H5.06
H5.07
H5.08
H5.09
H5.10
H5.11
H5.12
H5.13
H5.14
H5.15
H5.16
H5.17
H5.18
H5.19
H5.20
H5.21
H5.22
H5.23
H5.24
H5.25
H5.26