Arrestin Couplings
| Source | Receptor | Ligand | log(Emax/EC50) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Group | Cl | Rec. family |
Uniprot
|
IUPHAR | Name | Phys. / Surr. |
ARRB1 |
ARRB2 no GRK |
ARRB2 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT1A | 5-HT1A | 5-hydroxytryptamine | Phys | 6.6 | 3.2 | 7.9 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | 5-hydroxytryptamine | Phys | 1.8 | 1.2 | 2.5 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | 5-hydroxytryptamine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT2A | 5-HT2A | 5-hydroxytryptamine | Phys | 23.8 | 17.4 | 34.1 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | 5-hydroxytryptamine | Phys | 3.6 | 5.8 | 10.8 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | 5-hydroxytryptamine | Phys | 35.8 | 52.5 | 30.8 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM1 | M1 | acetylcholine | Phys | 7.2 | 0.0 | 8.9 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM2 | M2 | acetylcholine | Phys | 57.4 | 48.3 | 51.0 | |
| Bouvier | A | Dopamine | DRD2 | D2 | dopamine | Phys | 4.8 | 3.8 | 9.3 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM3 | M3 | acetylcholine | Phys | 4.5 | 1.2 | 9.5 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM4 | M4 | acetylcholine | Phys | 15.7 | 22.3 | 31.1 | |
| Bouvier | A | Adrenoceptors | ADA1A | α1A-adrenoceptor | noradrenaline | Phys | 0.0 | 0.0 | 0.8 | |
| Bouvier | A | Adrenoceptors | ADA2A | α2A-adrenoceptor | noradrenaline | Phys | 25.5 | 22.1 | 29.1 | |
| Bouvier | A | Adrenoceptors | ADA2B | α2B-adrenoceptor | noradrenaline | Phys | 5.3 | 5.0 | 15.7 | |
| Bouvier | A | Adrenoceptors | ADA2C | α2C-adrenoceptor | noradrenaline | Phys | 6.2 | 4.9 | 11.0 | |
| Bouvier | A | Adrenoceptors | ADRB1 | β1-adrenoceptor | noradrenaline | Phys | 14.1 | 10.8 | 14.5 | |
| Bouvier | A | Adrenoceptors | ADRB2 | β2-adrenoceptor | noradrenaline | Phys | 26.3 | 13.4 | 36.7 | |
| Bouvier | A | Dopamine | DRD1 | D1 | dopamine | Phys | 39.7 | 14.7 | 30.1 | |
| Bouvier | A | Dopamine | DRD5 | D5 | dopamine | Phys | 18.6 | 4.0 | 12.4 | |
| Bouvier | A | Histamine | HRH1 | H1 | histamine | Phys | 67.8 | 13.0 | 44.5 | |
| Bouvier | A | Histamine | HRH2 | H2 | histamine | Phys | 0.0 | 15.4 | 18.5 | |
| Bouvier | A | Angiotensin | AGTR1 | AT1 | angiotensin II | Phys | 6.3 | 7.0 | 9.7 | |
| Bouvier | A | Apelin | APJ | apelin | [Pyr1]apelin-13 | Phys | 16.1 | 7.7 | 7.7 | |
| Bouvier | A | Bradykinin | BKRB1 | B1 | kallidin | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Bradykinin | BKRB2 | B2 | kallidin | Phys | 62.1 | 58.3 | 51.6 | |
| Bouvier | A | Cholecystokinin | CCKAR | CCK1 | CCK-8 | Phys | 57.4 | 46.1 | 66.5 | |
| Bouvier | A | Complement peptide | C5AR1 | C5a1 | C5a | Phys | 83.3 | 100.0 | 100.0 | |
| Bouvier | A | Endothelin | EDNRA | ETA | endothelin-1 | Phys | 29.7 | 19.7 | 69.2 | |
| Bouvier | A | Ghrelin | GHSR | ghrelin | ghrelin | Phys | 12.4 | 2.3 | 7.4 | |
| Bouvier | A | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | GnRH I | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Melanocortin | MC3R | MC3 | γ-MSH | Phys | 28.3 | 1.9 | 27.3 | |
| Bouvier | A | Melanocortin | MC4R | MC4 | α-MSH | Phys | 3.2 | 0.0 | 3.3 | |
| Bouvier | A | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | RFRP-3 | Phys | 13.9 | 10.8 | 26.8 | |
| Bouvier | A | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | neuropeptide FF | Phys | 0.0 | 0.0 | 1.6 | |
| Bouvier | A | Neuropeptide Y | NPY1R | Y1 | neuropeptide Y | Phys | 0.0 | 0.7 | 1.8 | |
| Bouvier | A | Neuropeptide Y | NPY5R | Y5 | neuropeptide Y | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Opioid | OPRD | δ | SNC80 | Surr | 34.0 | 26.2 | 42.7 | |
| Bouvier | A | Opioid | OPRK | κ | dynorphin A | Phys | 11.8 | 7.1 | 10.2 | |
| Bouvier | A | Opioid | OPRM | μ | DAMGO | Surr | 26.1 | 33.8 | 52.4 | |
| Bouvier | A | Opioid | OPRX | NOP | nociceptin/orphanin FQ | Phys | 4.9 | 5.0 | 10.4 | |
| Bouvier | A | Orexin | OX2R | OX2 | orexin-A | Phys | 44.3 | 28.6 | 37.8 | |
| Bouvier | A | Proteinase-activated | PAR1 | PAR1 | TFLLR-NH2 | Phys | 30.7 | 15.0 | 20.5 | |
| Bouvier | A | Proteinase-activated | PAR2 | PAR2 | PAR2 peptide | Phys | 53.5 | 28.9 | 21.4 | |
| Bouvier | A | Somatostatin | SSR2 | SST2 | SRIF-14 | Phys | 100.0 | 96.2 | 79.6 | |
| Bouvier | A | Vasopressin and oxytocin | V1AR | V1A | vasopressin | Phys | 47.5 | 29.9 | 40.9 | |
| Bouvier | A | Vasopressin and oxytocin | V2R | V2 | vasopressin | Phys | 49.3 | 11.9 | 14.6 | |
| Bouvier | A | Vasopressin and oxytocin | OXYR | OT | oxytocin | Phys | 11.6 | 4.3 | 10.1 | |
| Bouvier | A | Chemokine | CCR5 | CCR5 | CCL3 | Phys | 21.1 | 33.5 | 51.6 | |
| Bouvier | A | Chemokine | CCR6 | CCR6 | CCL2 | Phys | 3.7 | 5.1 | 8.8 | |
| Bouvier | A | Chemokine | CXCR2 | CXCR2 | CXCL8 | Phys | 42.9 | 44.0 | 26.0 | |
| Bouvier | A | Chemokine | CXCR4 | CXCR4 | CXCL12α | Phys | 4.7 | 1.0 | 4.1 | |
| Bouvier | A | Chemokine | CXCR5 | CXCR5 | CXCL13 | Phys | 46.1 | 44.6 | 56.7 | |
| Bouvier | A | Free fatty acid | FFAR2 | FFA2 | propanoic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Free fatty acid | FFAR3 | FFA3 | propanoic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Free fatty acid | FFAR4 | FFA4 | α-linolenic acid | Phys | 69.4 | 36.5 | 43.7 | |
| Bouvier | A | Leukotriene | LT4R1 | BLT1 | LTB4 | Phys | 82.8 | 46.3 | 64.5 | |
| Bouvier | A | Leukotriene | LT4R2 | BLT2 | LTB4 | Phys | 1.6 | 0.0 | 2.8 | |
| Bouvier | A | Leukotriene | CLTR1 | CysLT1 | LTB4 | Phys | 17.6 | 13.7 | 19.6 | |
| Bouvier | A | Leukotriene | CLTR2 | CysLT2 | LTB4 | Phys | 93.4 | 4.2 | 4.2 | |
| Bouvier | A | Lysophospholipid (LPA) | LPAR1 | LPA1 | 2-oleoyl-LPA | Phys | 27.3 | 9.7 | 10.1 | |
| Bouvier | A | Lysophospholipid (LPA) | LPAR2 | LPA2 | 2-oleoyl-LPA | Phys | 34.8 | 24.0 | 41.1 | |
| Bouvier | A | Lysophospholipid (S1P) | S1PR1 | S1P1 | sphingosine 1-phosphate | Phys | 15.9 | 16.0 | 24.4 | |
| Bouvier | A | Cannabinoid | CNR1 | CB1 | WIN55212-2 | Surr | 17.4 | 0.0 | 10.6 | |
| Bouvier | A | Cannabinoid | CNR2 | CB2 | WIN55212-2 | Surr | 3.3 | 4.2 | 4.5 | |
| Bouvier | A | Prostanoid | PE2R1 | EP1 | PGE2 | Phys | 2.3 | 0.0 | 0.0 | |
| Bouvier | A | Prostanoid | PE2R2 | EP2 | PGE2 | Phys | 4.2 | 3.6 | 4.4 | |
| Bouvier | A | Prostanoid | PE2R3 | EP3 | PGE2 | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Prostanoid | PE2R4 | EP4 | PGE2 | Phys | 28.0 | 8.4 | 6.4 | |
| Bouvier | A | Prostanoid | PF2R | FP | PGD2 | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Melatonin | MTR1A | MT1 | melatonin | Phys | 12.8 | 2.6 | 6.9 | |
| Bouvier | A | Melatonin | MTR1B | MT2 | melatonin | Phys | 0.0 | 0.7 | 0.7 | |
| Bouvier | A | Adenosine | AA1R | A1 | adenosine | Phys | 2.8 | 0.0 | 2.7 | |
| Bouvier | A | Adenosine | AA2AR | A2A | adenosine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Adenosine | AA2BR | A2B | adenosine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Adenosine | AA3R | A3 | adenosine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | P2Y | P2RY2 | P2Y2 | UTP | Phys | 24.1 | 6.2 | 4.1 | |
| Bouvier | A | Bile acid | GPBAR | GPBA | lithocholic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Hydroxycarboxylic acid | HCAR2 | HCA2 | nicotinic acid | Phys | 11.7 | 3.3 | 14.1 | |
| Bouvier | A | Hydroxycarboxylic acid | HCAR3 | HCA3 | 3-hydroxyoctanoic acid | Phys | 8.1 | 20.3 | 21.3 | |
| Bouvier | A | A orphans | GPR4 | GPR4 | pH (proton) | Phys | 12.1 | 1.4 | 0.0 | |
| Bouvier | A | A orphans | GPR39 | GPR39 | Zn2+ | Phys | 4.3 | 0.0 | 1.8 | |
| Bouvier | A | A orphans | PSYR | GPR65 | pH (proton) | Phys | 4.8 | 1.9 | 0.0 | |
| Bouvier | A | A orphans | OGR1 | GPR68 | pH (proton) | Phys | 7.2 | 2.6 | 6.4 | |
| Bouvier | A | A orphans | GPR84 | GPR84 | undecanoic acid | Phys | 0.0 | 0.0 | 5.2 | |
| Bouvier | A | A orphans | GP183 | GPR183 | 7α,25-dihydroxycholesterol | Phys | 35.1 | 37.4 | 25.1 | |
| Bouvier | B1 | Calcitonin | CALCR | CT | Human Calcitonin (hCT) | Phys | 6.9 | 1.7 | 8.4 | |
| Bouvier | B1 | Corticotropin-releasing factor | CRFR1 | CRF1 | urocortin 2 | Phys | 17.9 | 9.8 | 21.1 | |
| Bouvier | B1 | Corticotropin-releasing factor | CRFR2 | CRF2 | urocortin 2 | Phys | 76.4 | 47.6 | 63.2 | |
| Bouvier | B1 | Glucagon | GIPR | GIP | gastric inhibitory polypeptide | Phys | 1.9 | 2.3 | 5.8 | |
| Bouvier | B1 | Glucagon | GLP1R | GLP-1 | glucagon-like peptide 1-(7-37) | Phys | 46.1 | 18.7 | 40.6 | |
| Bouvier | B1 | Glucagon | GLP2R | GLP-2 | glucagon-like peptide 2 | Phys | 16.0 | 20.3 | 30.4 | |
| Bouvier | B1 | Glucagon | GLR | glucagon | glucagon | Phys | 45.1 | 32.8 | 39.4 | |
| Bouvier | B1 | Parathyroid hormone | PTH1R | PTH1 | teriparatide | Phys | 64.4 | 91.1 | 69.3 | |
| Bouvier | B1 | VIP and PACAP | VIPR1 | VPAC1 | VIP | Phys | 48.6 | 45.9 | 46.4 | |
| Bouvier | C | Metabotropic glutamate | GRM2 | mGlu2 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM4 | mGlu4 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM5 | mGlu5 | L-glutamic acid | Phys | 0.7 | 0.0 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM6 | mGlu6 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM8 | mGlu8 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |