Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYY

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Calcitonin salmon P38 N-term hydrophobic
Calcitonin salmon P38 N-term Van der Waals
Calcitonin salmon Y41 N-term aromatic (edge-to-face)
Calcitonin salmon Y41 N-term Van der Waals
Calcitonin salmon D77 N-term Van der Waals
Calcitonin salmon G78 N-term Van der Waals
Calcitonin salmon W79 N-term Van der Waals
Calcitonin salmon W79 N-term hydrophobic
Calcitonin salmon F99 N-term Van der Waals
Calcitonin salmon F99 N-term hydrophobic
Calcitonin salmon P100 N-term hydrophobic
Calcitonin salmon P100 N-term Van der Waals
Calcitonin salmon D101 N-term polar (charge-assisted hydrogen bond)
Calcitonin salmon F102 N-term Van der Waals
Calcitonin salmon F102 N-term hydrophobic
Calcitonin salmon E123 N-term Van der Waals
Calcitonin salmon W128 N-term polar (hydrogen bond)
Calcitonin salmon W128 N-term Van der Waals
Calcitonin salmon S129 N-term Van der Waals
Calcitonin salmon S129 N-term polar (hydrogen bond with backbone)
Calcitonin salmon Y131 N-term Van der Waals
Calcitonin salmon Y131 N-term hydrophobic
Calcitonin salmon T132 N-term Van der Waals
Calcitonin salmon N135 N-term Van der Waals
Calcitonin salmon N135 N-term polar (hydrogen bond)
Calcitonin salmon T138 1.29x29 TM1 Van der Waals
Calcitonin salmon K141 1.32x32 TM1 Van der Waals
Calcitonin salmon L142 1.33x33 TM1 Van der Waals
Calcitonin salmon L142 1.33x33 TM1 hydrophobic
Calcitonin salmon A145 1.36x36 TM1 Van der Waals
Calcitonin salmon A145 1.36x36 TM1 hydrophobic
Calcitonin salmon Y146 1.37x37 TM1 Van der Waals
Calcitonin salmon Y146 1.37x37 TM1 polar (hydrogen bond)
Calcitonin salmon Y146 1.37x37 TM1 polar (hydrogen bond)
Calcitonin salmon L148 1.39x39 TM1 Van der Waals
Calcitonin salmon L148 1.39x39 TM1 hydrophobic
Calcitonin salmon Y149 1.40x40 TM1 Van der Waals
Calcitonin salmon Y149 1.40x40 TM1 hydrophobic
Calcitonin salmon I198 2.64x64 TM2 hydrophobic
Calcitonin salmon I198 2.64x64 TM2 Van der Waals
Calcitonin salmon H201 2.67x67 TM2 polar (hydrogen bond)
Calcitonin salmon H201 2.67x67 TM2 Van der Waals
Calcitonin salmon L202 2.68x68 TM2 Van der Waals
Calcitonin salmon L202 2.68x68 TM2 hydrophobic
Calcitonin salmon V206 ECL1 hydrophobic
Calcitonin salmon V206 ECL1 Van der Waals
Calcitonin salmon P207 ECL1 Van der Waals
Calcitonin salmon G209 ECL1 Van der Waals
Calcitonin salmon V212 ECL1 Van der Waals
Calcitonin salmon R213 ECL1 polar (charge-assisted hydrogen bond)
Calcitonin salmon Y234 3.44x44 TM3 hydrophobic
Calcitonin salmon Y234 3.44x44 TM3 Van der Waals
Calcitonin salmon N288 ECL2 Van der Waals
Calcitonin salmon L291 45.52x52 ECL2 hydrophobic
Calcitonin salmon L291 45.52x52 ECL2 Van der Waals
Calcitonin salmon S292 ECL2 Van der Waals
Calcitonin salmon V293 ECL2 Van der Waals
Calcitonin salmon V293 ECL2 polar (hydrogen bond with backbone)
Calcitonin salmon E294 ECL2 polar (charge-assisted hydrogen bond)
Calcitonin salmon L298 5.36x37 TM5 Van der Waals
Calcitonin salmon Y299 5.37x38 TM5 Van der Waals
Calcitonin salmon Y299 5.37x38 TM5 polar (hydrogen bond)
Calcitonin salmon H302 5.40x40 TM5 polar (hydrogen bond)
Calcitonin salmon V305 5.43x43 TM5 Van der Waals
Calcitonin salmon M306 5.44x44 TM5 Van der Waals
Calcitonin salmon M306 5.44x44 TM5 hydrophobic
Calcitonin salmon F356 6.53x53 TM6 Van der Waals
Calcitonin salmon F356 6.53x53 TM6 hydrophobic
Calcitonin salmon P360 ECL3 Van der Waals
Calcitonin salmon P360 ECL3 polar (hydrogen bond with backbone)
Calcitonin salmon W361 ECL3 hydrophobic
Calcitonin salmon W361 ECL3 Van der Waals
Calcitonin salmon R362 ECL3 Van der Waals
Calcitonin salmon R362 ECL3 polar (hydrogen bond with backbone)
Calcitonin salmon Y372 7.38x37 TM7 Van der Waals
Calcitonin salmon H377 7.43x42 TM7 Van der Waals
Calcitonin salmon I380 7.46x45 TM7 Van der Waals
Calcitonin salmon H381 7.47x46 TM7 Van der Waals

Ligands

Calcitonin salmon

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x25 1.29x29 T138
1x28 1.32x32 K141
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM2
2x57 2.64x64 I198
2x60 2.67x67 H201
2x61 2.68x68 L202
TM3
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x41 5.36x37 L298
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x47 5.43x43 V305
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x38 7.43x42 H377
7x41 7.46x45 I380
7x42 7.47x46 H381