CHEMBL4588808


SMILES Cc1cccc(NC(=O)CCN2CCN(c3ncccn3)CC2)c1
InChIKey LPWRTRRXYPVJKD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 325.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 6.28 6.88 7.48 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.03 5.19 5.34 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.73 5.78 5.83 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pIC50 5.67 6.02 6.37 ChEMBL
D4 DRD4 Human Dopamine A pEC50 6.25 6.25 6.25 ChEMBL
D2 DRD2 Human Dopamine A pIC50 4.93 4.93 4.93 ChEMBL