moxonidine


SMILES CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC
InChIKey WPNJAUFVNXKLIM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 241.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Rat Adrenoceptors A pKi 6.0 6.0 6.0 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 5.7 5.7 5.7 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.82 6.82 6.82 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.17 8.17 8.17 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.24 8.24 8.24 Drug Central
α2B ADA2B Rat Adrenoceptors A pKi 8.22 8.22 8.22 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.15 6.15 6.15 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.21 8.21 8.21 Drug Central
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.75 4.75 4.75 ChEMBL