(R)-Ro65-6570
| SMILES | O=C1NCN(C21CCN(CC2)[C@@H]1Cc2c3c1cccc3ccc2)c1ccccc1 |
| InChIKey | BBOAHBVXCYBKLC-JOCHJYFZSA-N |
Chemical properties
| Hydrogen bond acceptors | 3 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 2 |
| Molecular weight (Da) | 383.2 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| NOP | OPRX | Human | Opioid | A | pKi | 9.6 | 9.6 | 9.6 | Guide to Pharmacology |
| NOP | OPRX | Rat | Opioid | A | pKi | 9.39 | 9.39 | 9.39 | ChEMBL |
| κ | OPRK | Rat | Opioid | A | pKi | 7.7 | 7.7 | 7.7 | ChEMBL |
| NOP | OPRX | Human | Opioid | A | pKi | 9.6 | 9.6 | 9.6 | ChEMBL |
| μ | OPRM | Rat | Opioid | A | pKi | 8.4 | 8.4 | 8.4 | ChEMBL |
| δ | OPRD | Human | Opioid | A | pKi | 7.0 | 7.0 | 7.0 | ChEMBL |
| κ | OPRK | Human | Opioid | A | pKi | 7.7 | 7.7 | 7.7 | ChEMBL |
| μ | OPRM | Human | Opioid | A | pKi | 8.4 | 8.4 | 8.4 | ChEMBL |
| δ | OPRD | Rat | Opioid | A | pKi | 7.0 | 7.0 | 7.0 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| NOP | OPRX | Human | Opioid | A | pEC50 | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
| NOP | OPRX | Human | Opioid | A | pEC50 | 7.4 | 7.4 | 7.4 | ChEMBL |