tamsulosin


SMILES CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C
InChIKey DRHKJLXJIQTDTD-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 11
Molecular weight (Da) 408.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α1A α1B

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Human Adrenoceptors A pKi 9.7 10.2 10.7 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 8.1 8.9 9.7 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 9.2 9.7 10.2 Guide to Pharmacology
α2B ADA2B Rat Adrenoceptors A pKi 7.1 7.63 8.17 ChEMBL
α1B ADA1B Golden hamster Adrenoceptors A pKi 9.7 9.7 9.7 ChEMBL
α1A ADA1A Rabbit Adrenoceptors A pKd 9.8 9.8 9.8 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 9.9 9.9 9.9 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKd 10.6 10.6 10.6 ChEMBL
α1D ADA1D Rat Adrenoceptors A pKi 10.15 10.15 10.15 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKd 9.69 9.69 9.69 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 7.0 8.67 9.21 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKd 9.47 9.47 9.47 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 9.89 10.21 10.52 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 8.1 8.1 8.1 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.4 9.75 10.54 ChEMBL
α1A ADA1A Human Adrenoceptors A pKd 9.54 9.54 9.54 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.1 9.65 10.24 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.08 7.08 7.08 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.2 7.54 7.87 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.55 9.55 9.55 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.11 7.5 7.89 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 8.7 8.83 9.22 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 9.7 9.88 10.54 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 7.98 7.98 7.98 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 7.99 7.99 7.99 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
D2 DRD2 Human Dopamine A pKi 8.1 8.1 8.1 Drug Central
D3 DRD3 Human Dopamine A pKi 8.02 8.02 8.02 Drug Central
α1D ADA1D Rat Adrenoceptors A pKi 7.99 7.99 7.99 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 7.98 7.98 7.98 Drug Central
α2B ADA2B Rat Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
α1B ADA1B Golden hamster Adrenoceptors A pKi 8.01 8.01 8.01 Drug Central
α1A ADA1A Bovine Adrenoceptors A pKi 8.0 8.0 8.0 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.1 9.1 9.1 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.04 8.04 8.04 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Human Adrenoceptors A pIC50 8.32 8.35 8.38 ChEMBL
α1B ADA1B Human Adrenoceptors A pEC50 9.89 9.89 9.89 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 8.66 9.07 9.49 ChEMBL
α1A ADA1A Human Adrenoceptors A pEC50 10.15 10.15 10.15 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 8.85 9.34 9.82 ChEMBL