AMG-837


SMILES CC#C[C@H](c1ccc(cc1)OCc1cccc(c1)c1ccc(cc1)C(F)(F)F)CC(=O)O
InChIKey ZOPNBMMVVZRSGH-NRFANRHFSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 438.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FFA1 FFAR1 Human Free fatty acid A pKd 8.72 8.72 8.72 ChEMBL
FFA1 FFAR1 Human Free fatty acid A pKi 7.38 8.02 8.66 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FFA1 FFAR1 Human Free fatty acid A pEC50 8.5 8.5 8.5 Guide to Pharmacology
FFA1 FFAR1 Human Free fatty acid A pEC50 5.06 7.42 8.89 ChEMBL
FFA1 FFAR1 Mouse Free fatty acid A pEC50 7.89 8.36 8.82 ChEMBL
FFA1 FFAR1 Rat Free fatty acid A pEC50 7.64 8.06 8.49 ChEMBL