Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 49783414 | 17480 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258451 | 17480 | 0 | None | - | 1 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 11166796 | 82250 | 0 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | 1 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11504722 | 76054 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059588 | 76054 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248189 91900499 | 193167 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL539713 | 193167 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 71712463 | 90945 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402900 | 90945 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 53357011 | 82247 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | ||
| CHEMBL2179580 | 82247 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 11350913 | 136259 | 1 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741376 | 136259 | 1 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | ||
| 11961293 | 3698 | 13 | None | 5 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 8426 | 3698 | 13 | None | 5 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402904 | 3698 | 13 | None | 5 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| DB12725 | 3698 | 13 | None | 5 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 53354764 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 53354764 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 11842633 | 3906 | 17 | None | 7 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 8425 | 3906 | 17 | None | 7 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087337 | 3906 | 17 | None | 7 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 70686434 | 76049 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059583 | 76049 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248922 | 193221 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL540981 | 193221 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248319 | 193813 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553404 | 193813 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247953 | 194135 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558163 | 194135 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 71714541 | 90936 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402891 | 90936 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71714542 | 90937 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402892 | 90937 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 53354764 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | -1 | 2 | Rat | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 70694780 | 76048 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059582 | 76048 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 11606227 | 76051 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059585 | 76051 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 11627949 | 76053 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059587 | 76053 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248921 | 193566 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551013 | 193566 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248186 | 193780 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL552484 | 193780 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 11519716 | 193814 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553405 | 193814 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248321 | 193898 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555222 | 193898 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 71714544 | 90939 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402894 | 90939 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712327 | 90942 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402897 | 90942 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71451950 | 82249 | 5 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 71450132 | 82251 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179584 | 82251 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| 71451950 | 82249 | 5 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82250 | 0 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | 1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82250 | 0 | None | -1 | 2 | Rat | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | -1 | 2 | Rat | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82250 | 0 | None | -1 | 2 | Rat | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | -1 | 2 | Rat | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 53357029 | 82256 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| CHEMBL2179589 | 82256 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| 11166796 | 82250 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 135409453 | 3702 | 38 | None | 3 | 3 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 226 | 3702 | 38 | None | 3 | 3 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL76370 | 3702 | 38 | None | 3 | 3 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 44248435 | 193897 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555210 | 193897 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248680 | 193899 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555223 | 193899 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248313 91900492 | 194181 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558719 | 194181 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 71714540 | 90935 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402890 | 90935 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 66810955 | 90948 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402903 | 90948 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71462650 | 82253 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179586 | 82253 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| 71451950 | 82249 | 5 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11166796 | 82250 | 0 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 71451951 | 82252 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179585 | 82252 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | ||
| 71462651 | 82254 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179587 | 82254 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | ||
| 71451950 | 82249 | 5 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 44247820 91900493 | 193121 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL538706 | 193121 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247951 91900497 | 193233 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL541223 | 193233 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248923 | 193257 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL541968 | 193257 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247822 91900495 | 193833 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553685 | 193833 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248184 | 194478 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL561278 | 194478 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 71451950 | 82249 | 5 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 155565664 | 175020 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4580044 | 175020 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| 11493559 | 73051 | 0 | None | - | 1 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL201621 | 73051 | 0 | None | - | 1 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 11961293 | 3698 | 13 | None | 5 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| 8426 | 3698 | 13 | None | 5 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL2402904 | 3698 | 13 | None | 5 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| DB12725 | 3698 | 13 | None | 5 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| 71451950 | 82249 | 5 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 70688535 | 76050 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059584 | 76050 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248076 | 193364 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL549449 | 193364 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 71712466 | 90796 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2401750 | 90796 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712325 | 90940 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402895 | 90940 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712328 | 90943 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402898 | 90943 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712465 | 90947 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402902 | 90947 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 11166796 | 82250 | 0 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | -1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 71462652 | 82257 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| CHEMBL2179590 | 82257 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| 9952994 | 106474 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL315071 | 106474 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| 53357016 | 82248 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | ||
| CHEMBL2179581 | 82248 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | ||
| 70682173 | 76043 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059577 | 76043 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248439 | 194508 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL561398 | 194508 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 135409453 | 3702 | 38 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 226 | 3702 | 38 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL76370 | 3702 | 38 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 71712464 | 90946 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402901 | 90946 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 15295138 | 50774 | 0 | None | - | 1 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| CHEMBL157880 | 50774 | 0 | None | - | 1 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| 19081984 | 204228 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 336 | 7 | 1 | 4 | 3.8 | C=CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL84398 | 204228 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 336 | 7 | 1 | 4 | 3.8 | C=CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 49783210 | 17442 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258338 | 17442 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 5 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2012.05.034 | ||
| 5202 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL39 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2012.05.034 | ||
| DB08839 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2012.05.034 | ||
| 11225102 | 76056 | 2 | None | -1 | 2 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059590 | 76056 | 2 | None | -1 | 2 | Guinea pig | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| 10837280 91900491 | 194139 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558259 | 194139 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248317 | 194215 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559050 | 194215 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 11225102 | 76056 | 2 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059590 | 76056 | 2 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| 127039167 | 136285 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741608 | 136285 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 71712611 | 90932 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402887 | 90932 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 11225102 | 76056 | 2 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2059590 | 76056 | 2 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | ||
| 70684790 | 77139 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087333 | 77139 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 11432106 | 77141 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087335 | 77141 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 71462777 | 82538 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181171 | 82538 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 130946 | 201061 | 2 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL62023 | 201061 | 2 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| 5 | 139 | 66 | None | -138 | 28 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| 5202 | 139 | 66 | None | -138 | 28 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| CHEMBL39 | 139 | 66 | None | -138 | 28 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| DB08839 | 139 | 66 | None | -138 | 28 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1038/nature05991 | ||
| 44249186 | 193636 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551535 | 193636 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 15231247 91900477 | 193969 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | ||
| CHEMBL556438 | 193969 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | ||
| 44249053 | 194816 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL563445 | 194816 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 10545215 | 188385 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | ||
| CHEMBL50852 | 188385 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | ||
| 44247949 | 193434 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL549998 | 193434 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 127037817 | 136072 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC2C3CN(CC4CCOCC4)CC32)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739689 | 136072 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC2C3CN(CC4CCOCC4)CC32)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127041480 | 136091 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739862 | 136091 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44323264 | 205373 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL92100 | 205373 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 44281492 | 118354 | 2 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL34224 | 118354 | 2 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| 10757374 | 162530 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL41769 | 162530 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| 10757374 | 162530 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL41769 | 162530 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 10018558 | 50464 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 314 | 5 | 1 | 6 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCOCC1 | 10.1021/jm960320m | ||
| CHEMBL157631 | 50464 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 314 | 5 | 1 | 6 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCOCC1 | 10.1021/jm960320m | ||
| 5 | 139 | 66 | None | -138 | 28 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| 5202 | 139 | 66 | None | -138 | 28 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| CHEMBL39 | 139 | 66 | None | -138 | 28 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| DB08839 | 139 | 66 | None | -138 | 28 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| 3037881 | 99271 | 1 | None | - | 1 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 355 | 1 | 1 | 4 | 2.8 | Nc1c(Cl)cc2c3c(cccc13)C(=O)N([C@@H]1CN3CCC1CC3)C2=O | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL28499 | 99271 | 1 | None | - | 1 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 355 | 1 | 1 | 4 | 2.8 | Nc1c(Cl)cc2c3c(cccc13)C(=O)N([C@@H]1CN3CCC1CC3)C2=O | 10.1016/S0960-894X(00)80352-2 | ||
| 19081885 | 203623 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 4.0 | CCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL79637 | 203623 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 4.0 | CCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 257 | 3424 | 9 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 5311423 | 3424 | 9 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| CHEMBL114112 | 3424 | 9 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 11842633 | 3906 | 17 | None | -7 | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 8425 | 3906 | 17 | None | -7 | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087337 | 3906 | 17 | None | -7 | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 70684288 | 76052 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059586 | 76052 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248793 91900478 | 193940 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556235 | 193940 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248068 | 194202 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL558924 | 194202 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 44247817 91900489 | 194291 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559746 | 194291 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 67276147 | 77131 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087325 | 77131 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 70695322 | 77134 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087328 | 77134 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 131725 | 198743 | 2 | None | 3 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL59834 | 198743 | 2 | None | 3 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/S0960-894X(01)81243-9 | ||
| 44626295 | 196087 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL571799 | 196087 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| 44461665 | 104056 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 325 | 6 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL310451 | 104056 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 325 | 6 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 9882676 | 204036 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 296 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCNCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL82833 | 204036 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 296 | 5 | 2 | 4 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCNCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 11496400 | 11688 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL1181946 | 11688 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL199866 | 11688 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 10690483 | 49020 | 0 | None | - | 1 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 369 | 6 | 2 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(C)=O)CC1 | 10.1021/jm960320m | ||
| CHEMBL156348 | 49020 | 0 | None | - | 1 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 369 | 6 | 2 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(C)=O)CC1 | 10.1021/jm960320m | ||
| 127039820 | 136242 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 366 | 6 | 1 | 4 | 3.2 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741224 | 136242 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 366 | 6 | 1 | 4 | 3.2 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039507 | 136334 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 360 | 5 | 1 | 4 | 3.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)F)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742086 | 136334 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 360 | 5 | 1 | 4 | 3.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)F)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127041780 | 136141 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 416 | 6 | 1 | 5 | 3.4 | CC(C)c1nc(C(=O)NCC2(F)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740278 | 136141 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 416 | 6 | 1 | 5 | 3.4 | CC(C)c1nc(C(=O)NCC2(F)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44323269 | 11952 | 0 | None | - | 1 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL1183709 | 11952 | 0 | None | - | 1 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL314198 | 11952 | 0 | None | - | 1 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| 9905514 | 119164 | 0 | None | - | 1 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(O)CC1 | 10.1021/jm960320m | ||
| CHEMBL347235 | 119164 | 0 | None | - | 1 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(O)CC1 | 10.1021/jm960320m | ||
| 49783209 | 17412 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258223 | 17412 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 127042086 | 136182 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 5 | 2 | 6 | 2.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(O)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740708 | 136182 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 400 | 5 | 2 | 6 | 2.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(O)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042083 | 136347 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 344 | 6 | 1 | 5 | 2.3 | COCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742190 | 136347 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 344 | 6 | 1 | 5 | 2.3 | COCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 10381762 | 49023 | 0 | None | - | 1 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)C1 | 10.1021/jm960320m | ||
| CHEMBL156349 | 49023 | 0 | None | - | 1 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)C1 | 10.1021/jm960320m | ||
| 127041784 | 136309 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NC2CCN(CC3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741826 | 136309 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NC2CCN(CC3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 19081860 | 203976 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 324 | 6 | 1 | 4 | 3.6 | CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL82360 | 203976 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 324 | 6 | 1 | 4 | 3.6 | CCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 49783212 | 17479 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258450 | 17479 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 44249316 91900479 | 193672 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551820 | 193672 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| 44247811 | 193790 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL552693 | 193790 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | ||
| 44247813 | 193909 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL555447 | 193909 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | ||
| 44248072 | 193992 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL556595 | 193992 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 44249057 91900485 | 194415 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL560876 | 194415 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249188 | 194428 | 1 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL560940 | 194428 | 1 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 10828800 | 99713 | 0 | None | - | 1 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL288199 | 99713 | 0 | None | - | 1 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| 10828800 | 99713 | 0 | None | - | 1 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL288199 | 99713 | 0 | None | - | 1 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 44249311 | 193646 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551614 | 193646 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247945 | 194386 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL560597 | 194386 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 132337 | 3474 | 8 | None | -1 | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| 238 | 3474 | 8 | None | -1 | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| CHEMBL34291 | 3474 | 8 | None | -1 | 2 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| 44308599 | 201996 | 0 | None | - | 1 | Rat | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NCCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL67554 | 201996 | 0 | None | - | 1 | Rat | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NCCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 9819593 | 98335 | 2 | None | 3 | 2 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL27846 | 98335 | 2 | None | 3 | 2 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 10548275 | 48232 | 0 | None | - | 1 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 307 | 5 | 1 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)OCC[n+]1ccccc1 | 10.1021/jm960320m | ||
| CHEMBL155631 | 48232 | 0 | None | - | 1 | Guinea pig | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 307 | 5 | 1 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)OCC[n+]1ccccc1 | 10.1021/jm960320m | ||
| 54677674 | 112298 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3291085 | 112298 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3306918 | 112298 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| 5 | 139 | 66 | None | -29 | 28 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| 5202 | 139 | 66 | None | -29 | 28 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL39 | 139 | 66 | None | -29 | 28 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| DB08839 | 139 | 66 | None | -29 | 28 | Rat | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| 42618248 | 186435 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | ||
| CHEMBL490852 | 186435 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | ||
| 127039821 | 136098 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 352 | 5 | 1 | 4 | 2.9 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739931 | 136098 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 352 | 5 | 1 | 4 | 2.9 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039374 | 136283 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 372 | 6 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)F)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741595 | 136283 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 372 | 6 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)F)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039822 | 136197 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C(C)C)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740844 | 136197 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C(C)C)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 9905225 | 205206 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91147 | 205206 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 10802184 | 53858 | 0 | None | - | 1 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | ||
| CHEMBL160705 | 53858 | 0 | None | - | 1 | Guinea pig | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | ||
| 10570203 | 49271 | 0 | None | - | 1 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 355 | 6 | 2 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(N)=O)CC1 | 10.1021/jm960320m | ||
| CHEMBL156554 | 49271 | 0 | None | - | 1 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 355 | 6 | 2 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(N)=O)CC1 | 10.1021/jm960320m | ||
| 9927789 | 111001 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL327798 | 111001 | 0 | None | - | 1 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 127037820 | 136316 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 398 | 8 | 1 | 5 | 3.0 | COCC(C)(C)CN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741918 | 136316 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 398 | 8 | 1 | 5 | 3.0 | COCC(C)(C)CN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 235 | 2517 | 36 | None | -5 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 5311299 | 2517 | 36 | None | -5 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL286136 | 2517 | 36 | None | -5 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 132337 | 3474 | 8 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 238 | 3474 | 8 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL34291 | 3474 | 8 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 49783211 | 17443 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258339 | 17443 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 5311047 | 203045 | 30 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL74656 | 203045 | 30 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | ||
| 44248312 91900490 | 193450 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550122 | 193450 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248066 | 193506 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL550530 | 193506 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 70691118 | 77133 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087327 | 77133 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 70686943 | 77137 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087331 | 77137 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 1782 | 2472 | 81 | None | -158 | 12 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 241 | 2472 | 81 | None | -158 | 12 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 4168 | 2472 | 81 | None | -158 | 12 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL86 | 2472 | 81 | None | -158 | 12 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| DB01233 | 2472 | 81 | None | -158 | 12 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 11493794 | 72669 | 0 | None | 26 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL201019 | 72669 | 0 | None | 26 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 132164 | 204912 | 8 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL89259 | 204912 | 8 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 127039508 | 136293 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 5 | 1 | 5 | 3.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(F)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741703 | 136293 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 5 | 1 | 5 | 3.2 | CC(C)c1nc(C(=O)NC2CCN(CC3(F)CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 10493462 | 200791 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL61130 | 200791 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 19081864 | 104462 | 0 | None | - | 1 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 352 | 9 | 1 | 4 | 4.6 | CCCOc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL311325 | 104462 | 0 | None | - | 1 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 352 | 9 | 1 | 4 | 4.6 | CCCOc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| 183782 | 3334 | 15 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| 237 | 3334 | 15 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL85251 | 3334 | 15 | None | 3 | 3 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| 44213662 | 204861 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL88973 | 204861 | 0 | None | - | 1 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 71451950 | 82249 | 5 | None | -1 | 2 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | -1 | 2 | Rat | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 235 | 2517 | 36 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| 5311299 | 2517 | 36 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL286136 | 2517 | 36 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| 133076 | 3335 | 4 | None | -1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 3230 | 3335 | 4 | None | -1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL83899 | 3335 | 4 | None | -1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 10.1016/S0960-894X(01)80413-3 | ||
| 70696825 | 76044 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059578 | 76044 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 11677434 | 76047 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059581 | 76047 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 11225102 | 76056 | 2 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059590 | 76056 | 2 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248191 | 193220 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| CHEMBL540980 | 193220 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| 44248195 | 193402 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL549650 | 193402 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248679 | 193916 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555693 | 193916 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248315 | 194237 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559322 | 194237 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 135409453 | 3702 | 38 | None | 3 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 226 | 3702 | 38 | None | 3 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL76370 | 3702 | 38 | None | 3 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 135409453 | 3702 | 38 | None | 3 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 226 | 3702 | 38 | None | 3 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL76370 | 3702 | 38 | None | 3 | 3 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 155543353 | 172719 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4526049 | 172719 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| 127037818 | 136158 | 1 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136158 | 1 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127037818 | 136158 | 1 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136158 | 1 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127037818 | 136158 | 1 | None | 1 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136158 | 1 | None | 1 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039823 | 136171 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740612 | 136171 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(C4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 10567201 | 183673 | 0 | None | - | 1 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 313 | 5 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC1 | 10.1021/jm960853v | ||
| CHEMBL48379 | 183673 | 0 | None | - | 1 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 313 | 5 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC1 | 10.1021/jm960853v | ||
| 6604914 | 99906 | 2 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL28992 | 99906 | 2 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80441-2 | ||
| 9819119 | 201997 | 0 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL67555 | 201997 | 0 | None | - | 1 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC12CC3CN(CC3C1)C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 44281102 | 116202 | 0 | None | - | 1 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCC(OC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL33732 | 116202 | 0 | None | - | 1 | Guinea pig | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCC(OC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| 127037818 | 136158 | 1 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740472 | 136158 | 1 | None | -1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039819 | 136361 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | CC(C)c1nc(C(=O)NCC2CN(C3CCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742300 | 136361 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | CC(C)c1nc(C(=O)NCC2CN(C3CCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 132337 | 3474 | 8 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 238 | 3474 | 8 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| CHEMBL34291 | 3474 | 8 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 132337 | 3474 | 8 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020099f | ||
| 238 | 3474 | 8 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020099f | ||
| CHEMBL34291 | 3474 | 8 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020099f | ||
| 127039510 | 136184 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 370 | 5 | 1 | 5 | 2.7 | CC(C)c1nc(C(=O)NC2CCN(CC3CCOC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740732 | 136184 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 370 | 5 | 1 | 5 | 2.7 | CC(C)c1nc(C(=O)NC2CCN(CC3CCOC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44248797 | 194029 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL557053 | 194029 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 44248552 91900486 | 194235 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559317 | 194235 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 10574402 91900484 | 194788 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL563261 | 194788 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 70695323 | 77142 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087336 | 77142 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 71450247 | 82549 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181188 | 82549 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 203435 | 163541 | 2 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL420969 | 163541 | 2 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 71712612 | 90933 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402888 | 90933 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44249317 91900480 | 193661 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | ||
| CHEMBL551743 | 193661 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | ||
| 243 | 3141 | 85 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3052762 | 3141 | 85 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3502 | 3141 | 85 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL117287 | 3141 | 85 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| DB06480 | 3141 | 85 | None | -1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 108182 | 4055 | 18 | None | - | 1 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 245 | 4055 | 18 | None | - | 1 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL18041 | 4055 | 18 | None | - | 1 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 44288600 | 100635 | 0 | None | -1 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL295155 | 100635 | 0 | None | -1 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| 14403199 | 116097 | 0 | None | - | 1 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL33676 | 116097 | 0 | None | - | 1 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1016/S0960-894X(01)80508-4 | ||
| 14403199 | 116097 | 0 | None | - | 1 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1021/jm960320m | ||
| CHEMBL33676 | 116097 | 0 | None | - | 1 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1021/jm960320m | ||
| 10757373 | 49306 | 0 | None | - | 1 | Guinea pig | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 310 | 5 | 1 | 5 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC=CCC1 | 10.1021/jm960320m | ||
| CHEMBL156579 | 49306 | 0 | None | - | 1 | Guinea pig | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 310 | 5 | 1 | 5 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC=CCC1 | 10.1021/jm960320m | ||
| 3019427 | 60048 | 27 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL1748 | 60048 | 27 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | ||
| 9973684 | 51184 | 0 | None | - | 1 | Guinea pig | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C)CC1 | 10.1021/jm960320m | ||
| CHEMBL158238 | 51184 | 0 | None | - | 1 | Guinea pig | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C)CC1 | 10.1021/jm960320m | ||
| 44248193 | 193131 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| CHEMBL538956 | 193131 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| 44248434 91900496 | 193956 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556326 | 193956 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247943 | 194264 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL559548 | 194264 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 44249183 | 194696 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL562636 | 194696 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 71714543 | 90938 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402893 | 90938 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712329 | 90944 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402899 | 90944 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 127041783 | 136052 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(C(C)C)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739521 | 136052 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(C(C)C)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039509 | 136205 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 332 | 5 | 1 | 4 | 2.6 | CC(C)c1nc(C(=O)NC2CCN(CCF)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740908 | 136205 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 332 | 5 | 1 | 4 | 2.6 | CC(C)c1nc(C(=O)NC2CCN(CCF)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 183782 | 3334 | 15 | None | 3 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(01)80413-3 | ||
| 237 | 3334 | 15 | None | 3 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL85251 | 3334 | 15 | None | 3 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(01)80413-3 | ||
| 11168006 | 76055 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059589 | 76055 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248080 91900498 | 194193 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558855 | 194193 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 182593 | 3331 | 4 | None | 1 | 2 | Guinea pig | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 254 | 3331 | 4 | None | 1 | 2 | Guinea pig | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| CHEMBL83954 | 3331 | 4 | None | 1 | 2 | Guinea pig | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 10615288 | 186416 | 0 | None | - | 1 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | ||
| CHEMBL49072 | 186416 | 0 | None | - | 1 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | ||
| 127039824 | 136065 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739647 | 136065 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC4CCOCC4)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 10315431 | 98480 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 343 | 1 | 1 | 4 | 2.8 | CN1CCC(N2C(=O)c3cccc4c(N)c(Cl)cc(c34)C2=O)CC1 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL27966 | 98480 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 343 | 1 | 1 | 4 | 2.8 | CN1CCC(N2C(=O)c3cccc4c(N)c(Cl)cc(c34)C2=O)CC1 | 10.1016/S0960-894X(00)80352-2 | ||
| 44249055 91900481 | 193738 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL552218 | 193738 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 10643698 | 193771 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL552420 | 193771 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 70682705 | 77135 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087329 | 77135 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 127041781 | 136113 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 388 | 8 | 2 | 6 | 2.1 | COCCCN1CCC(O)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740030 | 136113 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 388 | 8 | 2 | 6 | 2.1 | COCCCN1CCC(O)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 10828801 | 103679 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 310 | 6 | 1 | 4 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)CCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL309655 | 103679 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 310 | 6 | 1 | 4 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)CCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 44248794 | 193830 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553658 | 193830 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 15095973 | 135732 | 0 | None | 12 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm0509501 | ||
| CHEMBL37333 | 135732 | 0 | None | 12 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm0509501 | ||
| 22400452 | 101901 | 0 | None | - | 1 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 363 | 4 | 2 | 4 | 2.1 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL303877 | 101901 | 0 | None | - | 1 | Rat | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 363 | 4 | 2 | 4 | 2.1 | COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 127037821 | 136260 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)O)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741377 | 136260 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)O)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44213663 | 204845 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL88867 | 204845 | 0 | None | - | 1 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 11596009 | 73012 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 342 | 3 | 1 | 5 | 2.4 | CC(C)n1c(=O)n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL201414 | 73012 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 342 | 3 | 1 | 5 | 2.4 | CC(C)n1c(=O)n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 9861932 | 201873 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL66768 | 201873 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 44323245 | 106528 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL315443 | 106528 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 73352662 | 92795 | 0 | None | - | 1 | Rat | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL2448137 | 92795 | 0 | None | - | 1 | Rat | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| 127042089 | 136088 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 384 | 5 | 2 | 5 | 3.0 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)O)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739826 | 136088 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 384 | 5 | 2 | 5 | 3.0 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC(C)(C)O)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 19081862 | 203673 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 310 | 5 | 1 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(C)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL80015 | 203673 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 310 | 5 | 1 | 4 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(C)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 9799010 | 204155 | 0 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL83841 | 204155 | 0 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 10757502 91929739 | 193445 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL550064 | 193445 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 10757502 91929739 | 193445 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550064 | 193445 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| 44247808 | 193699 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL551940 | 193699 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 44248187 91900482 | 193700 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL551941 | 193700 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 44248070 | 194141 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL558261 | 194141 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 44249056 91900483 | 194653 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL562400 | 194653 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 9799010 | 204155 | 0 | None | -1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL83841 | 204155 | 0 | None | -1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)CCCCN1CCCCC1 | 10.1016/S0960-894X(01)80414-5 | ||
| 9817713 | 193159 | 53 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL539652 | 193159 | 53 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | ||
| 42499 | 193258 | 20 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL541969 | 193258 | 20 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | ||
| 44247947 | 193653 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL551678 | 193653 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 235 | 2517 | 36 | None | -1 | 4 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 5311299 | 2517 | 36 | None | -1 | 4 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL286136 | 2517 | 36 | None | -1 | 4 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 235 | 2517 | 36 | None | -1 | 4 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 5311299 | 2517 | 36 | None | -1 | 4 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| CHEMBL286136 | 2517 | 36 | None | -1 | 4 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 15295138 | 50774 | 0 | None | - | 1 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| CHEMBL157880 | 50774 | 0 | None | - | 1 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| 44582815 | 172647 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | ||
| CHEMBL452353 | 172647 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | ||
| 9973683 | 119289 | 0 | None | - | 1 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCCC1 | 10.1021/jm960320m | ||
| CHEMBL348311 | 119289 | 0 | None | - | 1 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCCC1 | 10.1021/jm960320m | ||
| 22708808 | 205324 | 0 | None | - | 1 | Rat | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91771 | 205324 | 0 | None | - | 1 | Rat | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| 155525723 | 170509 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4457426 | 170509 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| 127041479 | 136308 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741821 | 136308 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 44371317 | 49778 | 0 | None | - | 1 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C2CCCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL156965 | 49778 | 0 | None | - | 1 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C2CCCC1CC2 | 10.1021/jm960320m | ||
| 10447437 | 49781 | 0 | None | - | 1 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | ||
| CHEMBL156970 | 49781 | 0 | None | - | 1 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | ||
| 127038726 | 136061 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 5 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739611 | 136061 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 5 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC2CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042084 | 136303 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 7 | 1 | 5 | 2.7 | COCCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741776 | 136303 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 358 | 7 | 1 | 5 | 2.7 | COCCCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 44343153 | 109845 | 0 | None | 1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| CHEMBL324057 | 109845 | 0 | None | 1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| 22400445 | 202386 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL70205 | 202386 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 131725 | 198743 | 2 | None | -3 | 2 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm960320m | ||
| CHEMBL59834 | 198743 | 2 | None | -3 | 2 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm960320m | ||
| 44281491 | 111969 | 0 | None | - | 1 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCCC(OC(=O)c2cc(Cl)c(N)cc2OC)C1 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL32986 | 111969 | 0 | None | - | 1 | Guinea pig | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCCC(OC(=O)c2cc(Cl)c(N)cc2OC)C1 | 10.1016/S0960-894X(01)80508-4 | ||
| 10065690 | 106930 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 337 | 4 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@]12C | 10.1016/j.bmcl.2004.04.021 | ||
| CHEMBL318154 | 106930 | 0 | None | - | 1 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 337 | 4 | 2 | 4 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@]12C | 10.1016/j.bmcl.2004.04.021 | ||
| 127042087 | 136272 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 386 | 5 | 1 | 6 | 2.1 | CC(C)c1nc(C(=O)NCC2CN(C3CCOCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741508 | 136272 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 386 | 5 | 1 | 6 | 2.1 | CC(C)c1nc(C(=O)NCC2CN(C3CCOCC3)CCO2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127038354 | 136099 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 386 | 7 | 1 | 5 | 3.3 | COCC(C)(C)CN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739933 | 136099 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 386 | 7 | 1 | 5 | 3.3 | COCC(C)(C)CN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 127041786 | 136045 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(CC3CC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739470 | 136045 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 340 | 5 | 1 | 4 | 3.1 | CC(C)c1nc(C(=O)NC2CCN(CC3CC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042085 | 136251 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 370 | 4 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741322 | 136251 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 370 | 4 | 1 | 5 | 2.8 | CC(C)c1nc(C(=O)NC2CCN(C3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 5 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| 5202 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL39 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| DB08839 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| 5 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| 5202 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| CHEMBL39 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| DB08839 | 139 | 66 | None | -13 | 28 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| 15295138 | 50774 | 0 | None | - | 1 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| CHEMBL157880 | 50774 | 0 | None | - | 1 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| 70688534 | 76045 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059579 | 76045 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 70696826 | 76046 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059580 | 76046 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 44247941 | 194105 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL557867 | 194105 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 44248925 | 194736 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL562902 | 194736 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 11842633 | 3906 | 17 | None | 7 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 8425 | 3906 | 17 | None | 7 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087337 | 3906 | 17 | None | 7 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 70695321 | 77132 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087326 | 77132 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 243 | 3141 | 85 | None | 1 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3052762 | 3141 | 85 | None | 1 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 3502 | 3141 | 85 | None | 1 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL117287 | 3141 | 85 | None | 1 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| DB06480 | 3141 | 85 | None | 1 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.ejmech.2015.08.051 | ||
| 10764565 | 48733 | 0 | None | - | 1 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCC[N+]12CCC(CC1)CC2 | 10.1021/jm960320m | ||
| CHEMBL156088 | 48733 | 0 | None | - | 1 | Guinea pig | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCC[N+]12CCC(CC1)CC2 | 10.1021/jm960320m | ||
| 1782 | 2472 | 81 | None | -3 | 12 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| 241 | 2472 | 81 | None | -3 | 12 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| 4168 | 2472 | 81 | None | -3 | 12 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| CHEMBL86 | 2472 | 81 | None | -3 | 12 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| DB01233 | 2472 | 81 | None | -3 | 12 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| 127042670 | 136276 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 384 | 7 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)CO)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741548 | 136276 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 384 | 7 | 2 | 5 | 2.4 | CC(C)c1nc(C(=O)NC[C@H]2[C@@H]3CN(CC(C)(C)CO)C[C@H]23)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 49783419 | 17552 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258671 | 17552 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 127041785 | 136154 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.7 | CCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740400 | 136154 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.7 | CCN1CCC(NC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 44248311 91900487 | 193947 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556279 | 193947 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 127039505 | 136147 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740313 | 136147 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 9819593 | 98335 | 2 | None | -3 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL27846 | 98335 | 2 | None | -3 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| 44249179 | 193145 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL539212 | 193145 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | ||
| 9906777 | 92799 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1021/jm0509501 | ||
| CHEMBL2448165 | 92799 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1021/jm0509501 | ||
| 9885123 | 107716 | 1 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL319673 | 107716 | 1 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL558226 | 107716 | 1 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(97)00408-3 | ||
| 235 | 2517 | 36 | None | -5 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| 5311299 | 2517 | 36 | None | -5 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| CHEMBL286136 | 2517 | 36 | None | -5 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| 9906777 | 92799 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL2448165 | 92799 | 0 | None | - | 1 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1016/S0960-894X(00)80441-2 | ||
| 127039503 | 136042 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 379 | 5 | 0 | 6 | 4.5 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739455 | 136042 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 379 | 5 | 0 | 6 | 4.5 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039169 | 136224 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 412 | 6 | 1 | 5 | 3.7 | CC(C)c1nc(C(=O)NCC2(C)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741062 | 136224 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 412 | 6 | 1 | 5 | 3.7 | CC(C)c1nc(C(=O)NCC2(C)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44288600 | 100635 | 0 | None | -1 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL295155 | 100635 | 0 | None | -1 | 2 | Rat | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/S0960-894X(00)80441-2 | ||
| 240 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 2769 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 44279790 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 660 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| CHEMBL1729 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| CHEMBL560739 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| DB00604 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 240 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 2769 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 44279790 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 660 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL1729 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL560739 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| DB00604 | 929 | 39 | None | -14 | 18 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/S0960-894X(00)80441-2 | ||
| 6604914 | 99906 | 2 | None | -1 | 2 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL28992 | 99906 | 2 | None | -1 | 2 | Rat | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | ||
| 127041782 | 136043 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739459 | 136043 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC3CCOCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 54677674 | 112298 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3291085 | 112298 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3306918 | 112298 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2015.08.051 | ||
| 10449091 | 119447 | 0 | None | - | 1 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1C | 10.1021/jm960320m | ||
| CHEMBL349809 | 119447 | 0 | None | - | 1 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1C | 10.1021/jm960320m | ||
| 71460941 | 82255 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179588 | 82255 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | ||
| 5 | 139 | 66 | None | -29 | 28 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| 5202 | 139 | 66 | None | -29 | 28 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL39 | 139 | 66 | None | -29 | 28 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| DB08839 | 139 | 66 | None | -29 | 28 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(00)80352-2 | ||
| 135409453 | 3702 | 38 | None | -3 | 3 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 226 | 3702 | 38 | None | -3 | 3 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL76370 | 3702 | 38 | None | -3 | 3 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 135409453 | 3702 | 38 | None | -3 | 3 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 226 | 3702 | 38 | None | -3 | 3 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL76370 | 3702 | 38 | None | -3 | 3 | Guinea pig | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 44249189 91900488 | 193721 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL552075 | 193721 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248433 91900494 | 195056 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL565146 | 195056 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 67276466 | 77130 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087324 | 77130 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 10569278 | 186657 | 0 | None | - | 1 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | ||
| CHEMBL49266 | 186657 | 0 | None | - | 1 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | ||
| 6604914 | 99906 | 2 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| CHEMBL28992 | 99906 | 2 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(00)80352-2 | ||
| 19081962 | 106363 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 380 | 10 | 1 | 4 | 5.2 | CCCCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL314489 | 106363 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 380 | 10 | 1 | 4 | 5.2 | CCCCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80413-3 | ||
| 20030109 | 194667 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL562477 | 194667 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | ||
| 71461050 | 82550 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181189 | 82550 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 44374544 | 52858 | 0 | None | - | 1 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL159825 | 52858 | 0 | None | - | 1 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(01)81243-9 | ||
| 44247815 | 194791 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL563276 | 194791 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 71712613 | 90934 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402889 | 90934 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44248795 | 195944 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| CHEMBL570780 | 195944 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| 127041779 | 136201 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 390 | 8 | 1 | 5 | 3.0 | COCCCN1CCC(F)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740864 | 136201 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 390 | 8 | 1 | 5 | 3.0 | COCCCN1CCC(F)(CNC(=O)c2nc(C(C)C)n3ccccc23)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 132337 | 3474 | 8 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 238 | 3474 | 8 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| CHEMBL34291 | 3474 | 8 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1016/j.bmcl.2004.04.021 | ||
| 22400445 | 202386 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL70205 | 202386 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 335 | 4 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 42618252 | 186088 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | ||
| CHEMBL488325 | 186088 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | ||
| 44213661 | 205338 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91842 | 205338 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 10498232 | 51076 | 0 | None | - | 1 | Guinea pig | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 352 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1 | 10.1021/jm960320m | ||
| CHEMBL158147 | 51076 | 0 | None | - | 1 | Guinea pig | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 352 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1 | 10.1021/jm960320m | ||
| 44248437 | 193158 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL539651 | 193158 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249315 | 193495 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550459 | 193495 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 67276168 | 77140 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087334 | 77140 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 9861932 | 201873 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| CHEMBL66768 | 201873 | 0 | None | - | 1 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 321 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 | 10.1016/S0960-894X(97)00408-3 | ||
| 127039168 | 136344 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 1.8 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742145 | 136344 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 388 | 6 | 3 | 6 | 1.8 | CC(C)c1nc(C(=O)NCC2(O)CCN(CC(C)(C)O)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039506 | 136044 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)n4ccccc34)o2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3739467 | 136044 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)n4ccccc34)o2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 6604914 | 99906 | 2 | None | 1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL28992 | 99906 | 2 | None | 1 | 2 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 71461049 | 82548 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181187 | 82548 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 44248310 | 194871 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL563799 | 194871 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44575 | 195829 | 1 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL570074 | 195829 | 1 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 240 | 929 | 39 | None | -1 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 2769 | 929 | 39 | None | -1 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 44279790 | 929 | 39 | None | -1 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 660 | 929 | 39 | None | -1 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL1729 | 929 | 39 | None | -1 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL560739 | 929 | 39 | None | -1 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| DB00604 | 929 | 39 | None | -1 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 5311047 | 203045 | 30 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL74656 | 203045 | 30 | None | 1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | ||
| 1782 | 2472 | 81 | None | -3 | 12 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| 241 | 2472 | 81 | None | -3 | 12 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| 4168 | 2472 | 81 | None | -3 | 12 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| CHEMBL86 | 2472 | 81 | None | -3 | 12 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| DB01233 | 2472 | 81 | None | -3 | 12 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80413-3 | ||
| 1782 | 2472 | 81 | None | -158 | 12 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| 241 | 2472 | 81 | None | -158 | 12 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| 4168 | 2472 | 81 | None | -158 | 12 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL86 | 2472 | 81 | None | -158 | 12 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| DB01233 | 2472 | 81 | None | -158 | 12 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)81243-9 | ||
| 44323244 | 12264 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL1185621 | 12264 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL423504 | 12264 | 0 | None | - | 1 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| 127037819 | 136177 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740669 | 136177 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 49783207 | 17381 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258109 | 17381 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 127039170 | 136237 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 4 | 0 | 6 | 4.2 | CC(C)c1nc(-c2nnc(C3CCN(C4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741199 | 136237 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 4 | 0 | 6 | 4.2 | CC(C)c1nc(-c2nnc(C3CCN(C4CCC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127039504 | 136109 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 5 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3740000 | 136109 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 365 | 5 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CC4)CC3)o2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 127042088 | 136333 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 426 | 5 | 2 | 6 | 2.7 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC2(O)CCOCC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3742080 | 136333 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 426 | 5 | 2 | 6 | 2.7 | CC(C)c1nc(C(=O)NC2CC3CCC(C2)N3CC2(O)CCOCC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 42618250 | 168883 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | ||
| CHEMBL442869 | 168883 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | ||
| 44372468 | 11555 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 380 | 6 | 2 | 3 | 3.5 | CCCC[N+]12CCCC(C1)C(NC(=O)c1cc(Cl)c(N)cc1OC)CC2 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL1181147 | 11555 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 380 | 6 | 2 | 3 | 3.5 | CCCC[N+]12CCCC(C1)C(NC(=O)c1cc(Cl)c(N)cc1OC)CC2 | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL156977 | 11555 | 0 | None | - | 1 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 380 | 6 | 2 | 3 | 3.5 | CCCC[N+]12CCCC(C1)C(NC(=O)c1cc(Cl)c(N)cc1OC)CC2 | 10.1016/S0960-894X(01)81243-9 | ||
| 127039825 | 136305 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 439 | 5 | 1 | 6 | 2.6 | COC(=O)N1CCC(N2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741787 | 136305 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 439 | 5 | 1 | 6 | 2.6 | COC(=O)N1CCC(N2C[C@H]3[C@H](CNC(=O)c4nc(C(C)C)n5ccccc45)[C@H]3C2)CC1 | 10.1016/j.ejmech.2015.08.051 | ||
| 439280 | 119501 | 104 | None | -13 | 7 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 220 | 3 | 4 | 3 | 0.8 | N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O | 10.1016/S0960-894X(01)81243-9 | ||
| 6971044 | 119501 | 104 | None | -13 | 7 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 220 | 3 | 4 | 3 | 0.8 | N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O | 10.1016/S0960-894X(01)81243-9 | ||
| CHEMBL350221 | 119501 | 104 | None | -13 | 7 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 220 | 3 | 4 | 3 | 0.8 | N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O | 10.1016/S0960-894X(01)81243-9 | ||
| 127041481 | 136297 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NCC2CCN(C3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741733 | 136297 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 3.5 | CC(C)c1nc(C(=O)NCC2CCN(C3CCC3)CC2)c2ccccn12 | 10.1016/j.ejmech.2015.08.051 | ||
| 44626294 | 197311 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL585567 | 197311 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | ||
| 6917985 | 92808 | 6 | None | 64 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN2CCC[C@@H]1C2 | 10.1021/jm0509501 | ||
| CHEMBL2448558 | 92808 | 6 | None | 64 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN2CCC[C@@H]1C2 | 10.1021/jm0509501 | ||
| 44374544 | 52858 | 0 | None | - | 1 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(00)80441-2 | ||
| CHEMBL159825 | 52858 | 0 | None | - | 1 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1016/S0960-894X(00)80441-2 | ||
| 121881 | 3421 | 21 | None | 281 | 3 | Guinea pig | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1021/jm00077a018 | ||
| 256 | 3421 | 21 | None | 281 | 3 | Guinea pig | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1021/jm00077a018 | ||
| CHEMBL68131 | 3421 | 21 | None | 281 | 3 | Guinea pig | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1021/jm00077a018 | ||
| 119376 | 1803 | 41 | None | 61 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm300573d | ||
| 247 | 1803 | 41 | None | 61 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm300573d | ||
| CHEMBL33884 | 1803 | 41 | None | 61 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm300573d | ||
| 10066755 | 114748 | 1 | None | - | 1 | Guinea pig | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 354 | 7 | 1 | 5 | 3.6 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm00077a018 | ||
| CHEMBL334818 | 114748 | 1 | None | - | 1 | Guinea pig | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 354 | 7 | 1 | 5 | 3.6 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm00077a018 | ||
| 9998229 | 20380 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 353 | 7 | 2 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm00077a018 | ||
| CHEMBL130809 | 20380 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 353 | 7 | 2 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm00077a018 | ||
| 10408029 | 16268 | 0 | None | - | 1 | Guinea pig | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm960320m | ||
| CHEMBL123377 | 16268 | 0 | None | - | 1 | Guinea pig | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm960320m | ||
| 10788092 | 53291 | 0 | None | - | 1 | Guinea pig | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 416 | 7 | 1 | 6 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm960320m | ||
| CHEMBL160237 | 53291 | 0 | None | - | 1 | Guinea pig | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 416 | 7 | 1 | 6 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm960320m | ||
| 10615288 | 186416 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | ||
| CHEMBL49072 | 186416 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | ||
| 249 | 2518 | 3 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 9905972 | 2518 | 3 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| CHEMBL155917 | 2518 | 3 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 119376 | 1803 | 41 | None | -61 | 4 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | ||
| 247 | 1803 | 41 | None | -61 | 4 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | ||
| CHEMBL33884 | 1803 | 41 | None | -61 | 4 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | ||
| 249 | 2518 | 3 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 9905972 | 2518 | 3 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| CHEMBL155917 | 2518 | 3 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 10854687 | 48277 | 0 | None | - | 1 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)(C)C1 | 10.1021/jm960320m | ||
| CHEMBL155682 | 48277 | 0 | None | - | 1 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 340 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)(C)C1 | 10.1021/jm960320m | ||
| 10522209 | 101213 | 0 | None | - | 1 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 355 | 5 | 2 | 5 | 3.5 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CC(C)CC(C)C1 | 10.1021/jm960853v | ||
| CHEMBL299408 | 101213 | 0 | None | - | 1 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 355 | 5 | 2 | 5 | 3.5 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CC(C)CC(C)C1 | 10.1021/jm960853v | ||
| 235 | 2517 | 36 | None | 1 | 4 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 5311299 | 2517 | 36 | None | 1 | 4 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL286136 | 2517 | 36 | None | 1 | 4 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 44628198 | 82297 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179674 | 82297 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 10447437 | 49781 | 0 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | ||
| CHEMBL156970 | 49781 | 0 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | ||
| 10569278 | 186657 | 0 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | ||
| CHEMBL49266 | 186657 | 0 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | ||
| 10545215 | 188385 | 0 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | ||
| CHEMBL50852 | 188385 | 0 | None | - | 1 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | ||
| 258 | 3498 | 25 | None | 2 | 3 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00077a018 | ||
| 5191 | 3498 | 25 | None | 2 | 3 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00077a018 | ||
| CHEMBL287045 | 3498 | 25 | None | 2 | 3 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00077a018 | ||
| 5 | 139 | 66 | None | -29 | 28 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| 5202 | 139 | 66 | None | -29 | 28 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL39 | 139 | 66 | None | -29 | 28 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| DB08839 | 139 | 66 | None | -29 | 28 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/S0960-894X(01)80508-4 | ||
| 10757374 | 162530 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL41769 | 162530 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| 10757374 | 162530 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL41769 | 162530 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 44371350 | 119650 | 0 | None | - | 1 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 342 | 5 | 1 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)OC(C)C1 | 10.1021/jm960320m | ||
| CHEMBL351570 | 119650 | 0 | None | - | 1 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 342 | 5 | 1 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)OC(C)C1 | 10.1021/jm960320m | ||
| 260 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1021/jm00077a018 | ||
| 2775 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1021/jm00077a018 | ||
| 656665 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1021/jm00077a018 | ||
| CHEMBL56564 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1021/jm00077a018 | ||
| DB11699 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1021/jm00077a018 | ||
| 10828800 | 99713 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL288199 | 99713 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| 10828800 | 99713 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL288199 | 99713 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 10020607 | 19523 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 347 | 6 | 0 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cccc3c2OCCCO3)CC1 | 10.1021/jm00077a018 | ||
| CHEMBL130118 | 19523 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 347 | 6 | 0 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cccc3c2OCCCO3)CC1 | 10.1021/jm00077a018 | ||
| 10404587 | 3326 | 3 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 10.1021/jm00077a018 | ||
| 251 | 3326 | 3 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 10.1021/jm00077a018 | ||
| CHEMBL130040 | 3326 | 3 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 10.1021/jm00077a018 | ||
| 44281492 | 118354 | 2 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL34224 | 118354 | 2 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| 10802184 | 53858 | 0 | None | - | 1 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | ||
| CHEMBL160705 | 53858 | 0 | None | - | 1 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | ||
| 10041634 | 22611 | 1 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 319 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(COC(=O)c2cccc3c2OCO3)CC1 | 10.1021/jm00077a018 | ||
| CHEMBL132826 | 22611 | 1 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 319 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(COC(=O)c2cccc3c2OCO3)CC1 | 10.1021/jm00077a018 | ||
| 258 | 3498 | 25 | None | 2 | 3 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| 5191 | 3498 | 25 | None | 2 | 3 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL287045 | 3498 | 25 | None | 2 | 3 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| 258 | 3498 | 25 | None | 2 | 3 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| 5191 | 3498 | 25 | None | 2 | 3 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| CHEMBL287045 | 3498 | 25 | None | 2 | 3 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| 19956256 | 114786 | 0 | None | -1 | 5 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | ||
| CHEMBL334923 | 114786 | 0 | None | -1 | 5 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 275 | 4 | 0 | 5 | 2.5 | Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C | 10.1016/s0960-894x(00)00691-0 | ||
| 68490431 | 82302 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179707 | 82302 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 44407083 | 73547 | 0 | None | - | 0 | Rat | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 2.8 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12 | 10.1021/jm0509501 | ||
| CHEMBL201946 | 73547 | 0 | None | - | 0 | Rat | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 2.8 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12 | 10.1021/jm0509501 | ||
| 11537858 | 134293 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 327 | 2 | 1 | 3 | 2.5 | CC1(C)C(=O)N(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL371883 | 134293 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 327 | 2 | 1 | 3 | 2.5 | CC1(C)C(=O)N(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 11515258 | 74036 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 5 | 2.6 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| CHEMBL202481 | 74036 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 319 | 3 | 0 | 5 | 2.6 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| 11529314 | 140796 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 284 | 3 | 1 | 4 | 1.5 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cccn2ccnc12 | 10.1021/jm0509501 | ||
| CHEMBL383554 | 140796 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 284 | 3 | 1 | 4 | 1.5 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cccn2ccnc12 | 10.1021/jm0509501 | ||
| 260 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/S0960-894X(00)80170-5 | ||
| 2775 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/S0960-894X(00)80170-5 | ||
| 656665 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/S0960-894X(00)80170-5 | ||
| CHEMBL56564 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/S0960-894X(00)80170-5 | ||
| DB11699 | 3796 | 49 | None | 3 | 3 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/S0960-894X(00)80170-5 | ||
| 11522273 | 140801 | 0 | None | - | 0 | Rat | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 299 | 3 | 0 | 5 | 2.2 | Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL383577 | 140801 | 0 | None | - | 0 | Rat | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 299 | 3 | 0 | 5 | 2.2 | Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 11580445 | 73601 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 312 | 4 | 1 | 4 | 2.1 | CCc1nc(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccn12 | 10.1021/jm0509501 | ||
| CHEMBL202149 | 73601 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 312 | 4 | 1 | 4 | 2.1 | CCc1nc(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccn12 | 10.1021/jm0509501 | ||
| 11580890 | 73583 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 302 | 3 | 1 | 3 | 2.9 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccc(F)cc12 | 10.1021/jm0509501 | ||
| CHEMBL202122 | 73583 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 302 | 3 | 1 | 3 | 2.9 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccc(F)cc12 | 10.1021/jm0509501 | ||
| 11508052 | 73474 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 285 | 3 | 1 | 4 | 2.2 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12 | 10.1021/jm0509501 | ||
| CHEMBL201878 | 73474 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 285 | 3 | 1 | 4 | 2.2 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12 | 10.1021/jm0509501 | ||
| 14403147 | 34653 | 2 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 298 | 2 | 1 | 4 | 1.9 | CN1C2CC(OC(=O)c3c[nH]c4ccccc34)CC1C1OC12 | 10.1016/S0960-894X(00)80170-5 | ||
| CHEMBL143197 | 34653 | 2 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 298 | 2 | 1 | 4 | 1.9 | CN1C2CC(OC(=O)c3c[nH]c4ccccc34)CC1C1OC12 | 10.1016/S0960-894X(00)80170-5 | ||
| 133999 | 73951 | 6 | None | - | 0 | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 318 | 3 | 1 | 4 | 2.2 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| CHEMBL202434 | 73951 | 6 | None | - | 0 | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 318 | 3 | 1 | 4 | 2.2 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| 11508567 | 165405 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.8 | COc1ccc2[nH]cc(C(=O)OC[C@@H]3CCN4CCC[C@@H]34)c2c1 | 10.1021/jm0509501 | ||
| CHEMBL425222 | 165405 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 314 | 4 | 1 | 4 | 2.8 | COc1ccc2[nH]cc(C(=O)OC[C@@H]3CCN4CCC[C@@H]34)c2c1 | 10.1021/jm0509501 | ||
| 11500906 | 134821 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 332 | 3 | 1 | 4 | 2.5 | Cc1cnc2c(C(=O)NC[C@@H]3CCN4CCC[C@@H]34)cc(Cl)cn12 | 10.1021/jm0509501 | ||
| CHEMBL372776 | 134821 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 332 | 3 | 1 | 4 | 2.5 | Cc1cnc2c(C(=O)NC[C@@H]3CCN4CCC[C@@H]34)cc(Cl)cn12 | 10.1021/jm0509501 | ||
| 119376 | 1803 | 41 | None | 61 | 4 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2010.10.011 | ||
| 247 | 1803 | 41 | None | 61 | 4 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL33884 | 1803 | 41 | None | 61 | 4 | Human | 10.1 | pKi | = | 10.1 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2010.10.011 | ||
| 119376 | 1803 | 41 | None | 61 | 4 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 247 | 1803 | 41 | None | 61 | 4 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| CHEMBL33884 | 1803 | 41 | None | 61 | 4 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 53318069 | 56127 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 344 | 7 | 2 | 4 | 2.9 | O=C(O)CCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632154 | 56127 | 0 | None | - | 0 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 344 | 7 | 2 | 4 | 2.9 | O=C(O)CCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 53318070 | 56128 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 371 | 8 | 2 | 4 | 3.0 | CCOC(=O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632155 | 56128 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 371 | 8 | 2 | 4 | 3.0 | CCOC(=O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 11557207 | 78630 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113160 | 78630 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm070552t | ||
| 17755141 | 78700 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113289 | 78700 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 46905984 | 10301 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1179 | 30 | 4 | 14 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)cc2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL1162955 | 10301 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1179 | 30 | 4 | 14 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)cc2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 44427806 | 143369 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1151 | 28 | 4 | 14 | 8.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)c2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL390202 | 143369 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1151 | 28 | 4 | 14 | 8.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)C(C)(C)C)c2)C(=O)C(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 10666935 | 206201 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| CHEMBL97019 | 206201 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| 17755040 | 78696 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113285 | 78696 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 17755140 | 78699 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 1155 | 26 | 4 | 16 | 7.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CCCc2ccc(CCCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113288 | 78699 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 1155 | 26 | 4 | 16 | 7.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CCCc2ccc(CCCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 11622025 | 143202 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL390075 | 143202 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| 17756519 | 78701 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1211 | 30 | 4 | 16 | 9.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113290 | 78701 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1211 | 30 | 4 | 16 | 9.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CCCc2cccc(CCCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 17756415 | 78698 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113287 | 78698 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2ccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 11724799 | 10417 | 0 | None | - | 0 | Rat | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1021/jm020099f | ||
| CHEMBL116913 | 10417 | 0 | None | - | 0 | Rat | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1021/jm020099f | ||
| 17754944 | 78702 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 955 | 23 | 3 | 11 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCCCC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113291 | 78702 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 955 | 23 | 3 | 11 | 8.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCCCC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 53325991 | 56129 | 3 | None | - | 0 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 343 | 7 | 3 | 3 | 2.5 | O=C(O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632156 | 56129 | 3 | None | - | 0 | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 343 | 7 | 3 | 3 | 2.5 | O=C(O)CCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 17756414 | 78697 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113286 | 78697 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1203 | 24 | 4 | 16 | 8.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 17755039 | 78694 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1146 | 20 | 4 | 16 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CC#Cc2ccc(C#CCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113283 | 78694 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 1146 | 20 | 4 | 16 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CN(CC#Cc2ccc(C#CCN(CC(=O)NCC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 235 | 2517 | 36 | None | -5 | 4 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 5311299 | 2517 | 36 | None | -5 | 4 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| CHEMBL286136 | 2517 | 36 | None | -5 | 4 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 11643822 | 157305 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL408379 | 157305 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm070552t | ||
| 10666935 | 206201 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| CHEMBL97019 | 206201 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm020099f | ||
| 11513350 | 143372 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 778 | 18 | 4 | 12 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL390205 | 143372 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 778 | 18 | 4 | 12 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| 243 | 3141 | 85 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 3052762 | 3141 | 85 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 3502 | 3141 | 85 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| CHEMBL117287 | 3141 | 85 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| DB06480 | 3141 | 85 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 17756314 | 78695 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113284 | 78695 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 1175 | 22 | 4 | 16 | 7.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CC#Cc2cccc(C#CCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)c2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 11714901 | 133796 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| CHEMBL371718 | 133796 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm070552t | ||
| 10688893 | 206636 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm020099f | ||
| CHEMBL99591 | 206636 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm020099f | ||
| 1782 | 2472 | 81 | None | -3 | 12 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | None | -3 | 12 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | None | -3 | 12 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | None | -3 | 12 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | None | -3 | 12 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 243 | 3141 | 85 | None | -1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3052762 | 3141 | 85 | None | -1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3502 | 3141 | 85 | None | -1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| CHEMBL117287 | 3141 | 85 | None | -1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| DB06480 | 3141 | 85 | None | -1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 135526515 | 215990 | 0 | None | - | 1 | Guinea pig | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 301 | 7 | 4 | 3 | 2.8 | CCCCCNC(=N)NN=CC1=CNC2=C1C=C(OC)C=C2 | None | ||
| 133076 | 3335 | 4 | None | 1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 8903510 | ||
| 3230 | 3335 | 4 | None | 1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 8903510 | ||
| CHEMBL83899 | 3335 | 4 | None | 1 | 2 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | 417 | 9 | 2 | 6 | 2.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CCNS(=O)(=O)C)Cl | 8903510 | ||
| 4223 | 3917 | 88 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 6918314 | 3917 | 88 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 7427 | 3917 | 88 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| CHEMBL439849 | 3917 | 88 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| DB06684 | 3917 | 88 | None | -177 | 16 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 4223 | 3917 | 88 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 6918314 | 3917 | 88 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 7427 | 3917 | 88 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| CHEMBL439849 | 3917 | 88 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| DB06684 | 3917 | 88 | None | -177 | 16 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | None | ||
| 4223 | 3917 | 88 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| 6918314 | 3917 | 88 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| 7427 | 3917 | 88 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| CHEMBL439849 | 3917 | 88 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| DB06684 | 3917 | 88 | None | -177 | 16 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 15341484 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 145973928 | 164006 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4215329 | 164006 | 0 | None | - | 0 | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145975193 | 163308 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccc3cc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4206847 | 163308 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccc3cc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145973097 | 164155 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 412 | 6 | 2 | 5 | 3.6 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCCCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4217381 | 164155 | 0 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 412 | 6 | 2 | 5 | 3.6 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCCCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145965246 | 163658 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4211044 | 163658 | 0 | None | - | 0 | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 414 | 6 | 2 | 6 | 2.4 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4(O)CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 77105903 | 163437 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4208302 | 163437 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC4CCOCC4)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145967487 | 163837 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4213334 | 163837 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145972577 | 164054 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 372 | 6 | 2 | 5 | 2.7 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC(C)(C)O)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4216003 | 164054 | 0 | None | - | 0 | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 372 | 6 | 2 | 5 | 2.7 | CC(C)c1cn2cccc(C(=O)NCC3CCN(CC(C)(C)O)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 11350913 | 136259 | 1 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL3741376 | 136259 | 1 | None | - | 0 | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 430 | 5 | 2 | 7 | 2.2 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2ccccc21 | 10.1016/j.ejmech.2015.08.051 | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145975035 | 162967 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccn3cc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4202791 | 162967 | 0 | None | - | 0 | Human | 8.8 | pEC50 | = | 8.8 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2cccn3cc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145966407 | 163652 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NCC2C3CN(C4CCOCC4)CC23)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4210983 | 163652 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1nc(C(=O)NCC2C3CN(C4CCOCC4)CC23)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| 68592173 | 137303 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759944 | 137303 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 5311047 | 203045 | 30 | None | - | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL74656 | 203045 | 30 | None | - | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 67922794 | 137182 | 0 | None | - | 0 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758945 | 137182 | 0 | None | - | 0 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 145977971 | 163445 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 406 | 8 | 1 | 5 | 3.6 | COCCCN1CCC(CNC(=O)c2cccn3c(Cl)c(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4208394 | 163445 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 406 | 8 | 1 | 5 | 3.6 | COCCCN1CCC(CNC(=O)c2cccn3c(Cl)c(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 10584 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | ||
| 86582973 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417009 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | ||
| 9975257 | 48475 | 1 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | ||
| CHEMBL15585 | 48475 | 1 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | ||
| 9797313 | 101446 | 1 | None | - | 3 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | ||
| CHEMBL301039 | 101446 | 1 | None | - | 3 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | ||
| 145975740 | 163424 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4208144 | 163424 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 135409453 | 3702 | 38 | None | - | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 226 | 3702 | 38 | None | - | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL76370 | 3702 | 38 | None | - | 2 | Guinea pig | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 9975257 | 48475 | 1 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | ||
| CHEMBL15585 | 48475 | 1 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | ||
| 9797313 | 101446 | 1 | None | - | 3 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | ||
| CHEMBL301039 | 101446 | 1 | None | - | 3 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | ||
| 145973946 | 164048 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3nc(C(C)C)c4ccccn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4215943 | 164048 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3nc(C(C)C)c4ccccn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145978459 | 163013 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccn4cc(C(C)C)nc34)C2C1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4203277 | 163013 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccn4cc(C(C)C)nc34)C2C1 | 10.1021/acs.jmedchem.8b00457 | ||
| 10521792 | 110089 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.6 | Nc1c(Cl)cc(C(=O)NCCC23CCCN2CCC3)c2c1CCO2 | 10.1021/jm020099f | ||
| CHEMBL325494 | 110089 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.6 | Nc1c(Cl)cc(C(=O)NCCC23CCCN2CCC3)c2c1CCO2 | 10.1021/jm020099f | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 68593871 | 137226 | 0 | None | - | 0 | Rat | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759348 | 137226 | 0 | None | - | 0 | Rat | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | ||
| 54677674 | 112298 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL3291085 | 112298 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL3306918 | 112298 | 4 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | ||
| 145964870 | 163847 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC(C)(C)O)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4213441 | 163847 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 370 | 6 | 2 | 5 | 2.1 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(CC(C)(C)O)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145976249 | 162981 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccn3nc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4202922 | 162981 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccn3nc(C(C)C)nc23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145977126 | 163235 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccc3nc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4206020 | 163235 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 2.3 | COCCCN1CCC(CNC(=O)c2cccc3nc(C(C)C)nn23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 11961293 | 3698 | 13 | None | - | 1 | Guinea pig | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 8426 | 3698 | 13 | None | - | 1 | Guinea pig | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402904 | 3698 | 13 | None | - | 1 | Guinea pig | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| DB12725 | 3698 | 13 | None | - | 1 | Guinea pig | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 138376515 | 163225 | 3 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4205936 | 163225 | 3 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 127037818 | 136158 | 1 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2019.111569 | ||
| CHEMBL3740472 | 136158 | 1 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1C[C@H]2[C@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@H]2C1 | 10.1016/j.ejmech.2019.111569 | ||
| 127027397 | 137092 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758199 | 137092 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| 44288600 | 100635 | 0 | None | - | 1 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| CHEMBL295155 | 100635 | 0 | None | - | 1 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| 145974756 | 164194 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.2 | CC(C)c1nn2c(C(=O)NCC3C4CN(C5CCOCC5)CC34)cccc2c1Cl | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4217842 | 164194 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.2 | CC(C)c1nn2c(C(=O)NCC3C4CN(C5CCOCC5)CC34)cccc2c1Cl | 10.1021/acs.jmedchem.8b00457 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 145975076 | 163059 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C(C)C)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4203778 | 163059 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 340 | 5 | 1 | 4 | 2.8 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C(C)C)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145972323 | 164028 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4215651 | 164028 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 2.5 | CC(C)c1cn2cccc(C(=O)NCC3C4CN(C5CCOCC5)CC34)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 155554403 | 174050 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 330 | 2 | 1 | 3 | 1.9 | CCN1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | ||
| CHEMBL4557961 | 174050 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 330 | 2 | 1 | 3 | 1.9 | CCN1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | ||
| 19426720 | 110104 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.4 | CCn1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| CHEMBL325603 | 110104 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.4 | CCn1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| 68592299 | 137216 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759259 | 137216 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 235 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| 5311299 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL286136 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/j.ejmech.2015.08.051 | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 145975067 | 163029 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3nc(C(C)C)c4ccccn34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4203491 | 163029 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 455 | 6 | 1 | 6 | 3.4 | COC(=O)N1CCC(CN2CCC(CNC(=O)c3nc(C(C)C)c4ccccn34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145964080 | 163601 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4210381 | 163601 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 384 | 5 | 1 | 5 | 3.1 | CC(C)c1nc(C(=O)NCC2CCN(C3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| 25016328 | 137287 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759860 | 137287 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 145977443 | 163374 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(C(C)C)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4207586 | 163374 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(C(C)C)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| 145978825 | 163335 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCOCC4)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4207136 | 163335 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(CC4CCOCC4)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.8b00457 | ||
| 44288600 | 100635 | 0 | None | - | 1 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| CHEMBL295155 | 100635 | 0 | None | - | 1 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| 145975297 | 163030 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(C(C)C)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4203494 | 163030 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(C(C)C)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 9928343 | 102982 | 0 | None | - | 1 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| CHEMBL3085015 | 102982 | 0 | None | - | 1 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| 54677674 | 112298 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL3291085 | 112298 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL3306918 | 112298 | 4 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1021/acs.jmedchem.8b00457 | ||
| 145966243 | 163797 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cn2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4212757 | 163797 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cn2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 138376515 | 163225 | 3 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4205936 | 163225 | 3 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145972573 | 164046 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4215911 | 164046 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 138376515 | 163225 | 3 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4205936 | 163225 | 3 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.1 | CC(C)c1cc2cccc(-c3nnc(C4CCN(CC5CCOCC5)CC4)o3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145972573 | 164046 | 0 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4215911 | 164046 | 0 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 11225102 | 76056 | 2 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059590 | 76056 | 2 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| 127027375 | 137302 | 0 | None | - | 0 | Rat | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759928 | 137302 | 0 | None | - | 0 | Rat | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 145972573 | 164046 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4215911 | 164046 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccc4cc(C(C)C)nn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145978541 | 163182 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)c3ccccn23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4205387 | 163182 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 372 | 8 | 1 | 5 | 2.9 | COCCCN1CCC(CNC(=O)c2nc(C(C)C)c3ccccn23)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 68592484 | 137180 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758932 | 137180 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 145968234 | 164219 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccn4cc(C(C)C)nc34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4218152 | 164219 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3cccn4cc(C(C)C)nc34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145966863 | 163582 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccc4cc(C(C)C)nn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4210176 | 163582 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 370 | 8 | 1 | 5 | 2.4 | COCCCN1CC2C(CNC(=O)c3cccc4cc(C(C)C)nn34)C2C1 | 10.1021/acs.jmedchem.8b00457 | ||
| 68593479 | 137261 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759601 | 137261 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 155558212 | 174144 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 344 | 2 | 1 | 3 | 2.3 | CC(C)N1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | ||
| CHEMBL4560185 | 174144 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 344 | 2 | 1 | 3 | 2.3 | CC(C)N1C(=O)N(C(=O)NC2CC3CCC(C2)N3C)C2C=CC=CC21 | 10.1016/j.ejmech.2019.111569 | ||
| 44343153 | 109845 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| CHEMBL324057 | 109845 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 356 | 2 | 1 | 5 | 3.0 | CC(C)n1c(=O)n(C(=O)NC2CC3CCCC(C2)N3C)c2ccccc21 | 10.1021/jm020099f | ||
| 9975257 | 48475 | 1 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | ||
| CHEMBL15585 | 48475 | 1 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 351 | 3 | 2 | 4 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2C(C)CCCC2C1 | 10.1021/jm020099f | ||
| 9797313 | 101446 | 1 | None | - | 3 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | ||
| CHEMBL301039 | 101446 | 1 | None | - | 3 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020099f | ||
| 9928343 | 102982 | 0 | None | - | 1 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| CHEMBL3085015 | 102982 | 0 | None | - | 1 | Guinea pig | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| 145978151 | 163364 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4207406 | 163364 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 4.1 | CC(C)c1nc(-c2nnc(C3CCN(C(C)C)CC3)o2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| 145964746 | 163587 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 2.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCOCC4)CC3)cccn2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4210213 | 163587 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 2.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCOCC4)CC3)cccn2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145977409 | 163293 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)c4ccccn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4206608 | 163293 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 383 | 7 | 0 | 7 | 3.7 | COCCCN1CCC(c2nnc(-c3nc(C(C)C)c4ccccn34)o2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145978067 | 163172 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2CC3C(CNC(=O)c4cccc5cc(C(C)C)nn45)C3C2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4205273 | 163172 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 453 | 6 | 1 | 6 | 2.8 | COC(=O)N1CCC(CN2CC3C(CNC(=O)c4cccc5cc(C(C)C)nn45)C3C2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145965914 | 163572 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 441 | 5 | 1 | 6 | 3.1 | COC(=O)N1CCC(N2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4210063 | 163572 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 441 | 5 | 1 | 6 | 3.1 | COC(=O)N1CCC(N2CCC(CNC(=O)c3cccn4cc(C(C)C)nc34)CC2)CC1 | 10.1021/acs.jmedchem.8b00457 | ||
| 11961293 | 3698 | 13 | None | - | 1 | Guinea pig | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| 8426 | 3698 | 13 | None | - | 1 | Guinea pig | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL2402904 | 3698 | 13 | None | - | 1 | Guinea pig | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| DB12725 | 3698 | 13 | None | - | 1 | Guinea pig | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.ejmech.2015.08.051 | ||
| 183782 | 3334 | 15 | None | - | 15 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| 237 | 3334 | 15 | None | - | 15 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| CHEMBL85251 | 3334 | 15 | None | - | 15 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2015.08.051 | ||
| 145964157 | 163765 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cc2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4212433 | 163765 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 2.8 | CC(C)c1cc2cccc(C(=O)NCC3C4CN(CC5CCOCC5)CC34)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145977034 | 163053 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4203734 | 163053 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 3.3 | CC(C)c1nc(C(=O)NCC2CCN(CC3CCOCC3)CC2)n2ccccc12 | 10.1021/acs.jmedchem.8b00457 | ||
| 145968730 | 164277 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(C(C)C)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4218868 | 164277 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cn2cccc(C(=O)NCC3CCN(C(C)C)CC3)c2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 145974160 | 164017 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(C(C)C)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| CHEMBL4215511 | 164017 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 342 | 5 | 1 | 4 | 3.3 | CC(C)c1cc2cccc(C(=O)NCC3CCN(C(C)C)CC3)n2n1 | 10.1021/acs.jmedchem.8b00457 | ||
| 15166837 | 121860 | 0 | None | - | 1 | Rat | 5.9 | pED50 | = | 5.9 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| CHEMBL36005 | 121860 | 0 | None | - | 1 | Rat | 5.9 | pED50 | = | 5.9 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | CCOc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 7.8 | pED50 | = | 7.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00086a019 | ||
| 57391435 | 67374 | 0 | None | - | 0 | Rat | 6.8 | pED50 | = | 6.8 | Binding | ChEMBL | 307 | 3 | 2 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@]12CN3CCC1C2C3 | 10.1021/jm00086a019 | ||
| CHEMBL1907770 | 67374 | 0 | None | - | 0 | Rat | 6.8 | pED50 | = | 6.8 | Binding | ChEMBL | 307 | 3 | 2 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@]12CN3CCC1C2C3 | 10.1021/jm00086a019 | ||
| 15166838 | 41435 | 0 | None | - | 0 | Rat | 6.7 | pED50 | = | 6.7 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| CHEMBL14923 | 41435 | 0 | None | - | 0 | Rat | 6.7 | pED50 | = | 6.7 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| 10358856 | 119670 | 0 | None | - | 1 | Rat | 5.6 | pED50 | = | 5.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.3 | CCOc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| CHEMBL35180 | 119670 | 0 | None | - | 1 | Rat | 5.6 | pED50 | = | 5.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.3 | CCOc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| 132337 | 3474 | 8 | None | - | 2 | Rat | 7.6 | pED50 | = | 7.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm00086a019 | ||
| 238 | 3474 | 8 | None | - | 2 | Rat | 7.6 | pED50 | = | 7.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm00086a019 | ||
| CHEMBL34291 | 3474 | 8 | None | - | 2 | Rat | 7.6 | pED50 | = | 7.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm00086a019 | ||
| 1782 | 2472 | 81 | None | -11 | 23 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | ||
| 241 | 2472 | 81 | None | -11 | 23 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | ||
| 4168 | 2472 | 81 | None | -11 | 23 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | ||
| CHEMBL86 | 2472 | 81 | None | -11 | 23 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | ||
| DB01233 | 2472 | 81 | None | -11 | 23 | Rat | 4.6 | pED50 | = | 4.6 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm00086a019 | ||
| 15095972 | 137007 | 0 | None | - | 0 | Rat | 6.6 | pED50 | = | 6.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| CHEMBL37544 | 137007 | 0 | None | - | 0 | Rat | 6.6 | pED50 | = | 6.6 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| 15095973 | 135732 | 0 | None | - | 0 | Rat | 6.5 | pED50 | = | 6.5 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm00086a019 | ||
| CHEMBL37333 | 135732 | 0 | None | - | 0 | Rat | 6.5 | pED50 | = | 6.5 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN2CCC[C@H]12 | 10.1021/jm00086a019 | ||
| 15166838 | 41435 | 0 | None | - | 0 | Rat | 5.5 | pED50 | = | 5.5 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| CHEMBL14923 | 41435 | 0 | None | - | 0 | Rat | 5.5 | pED50 | = | 5.5 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| 44283512 | 139637 | 0 | None | - | 0 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 341 | 3 | 0 | 5 | 3.3 | CC(C)n1c(=O)n(C(=O)CC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm00086a019 | ||
| CHEMBL38041 | 139637 | 0 | None | - | 0 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 341 | 3 | 0 | 5 | 3.3 | CC(C)n1c(=O)n(C(=O)CC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm00086a019 | ||
| 44374544 | 52858 | 0 | None | - | 1 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1021/jm00086a019 | ||
| CHEMBL159825 | 52858 | 0 | None | - | 1 | Rat | 7.4 | pED50 | = | 7.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1021/jm00086a019 | ||
| 9819593 | 98335 | 2 | None | 1 | 2 | Rat | 6.3 | pED50 | = | 6.3 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm00086a019 | ||
| CHEMBL27846 | 98335 | 2 | None | 1 | 2 | Rat | 6.3 | pED50 | = | 6.3 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm00086a019 | ||
| 240 | 929 | 39 | None | -8 | 25 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | ||
| 2769 | 929 | 39 | None | -8 | 25 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | ||
| 44279790 | 929 | 39 | None | -8 | 25 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | ||
| 660 | 929 | 39 | None | -8 | 25 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | ||
| CHEMBL1729 | 929 | 39 | None | -8 | 25 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | ||
| CHEMBL560739 | 929 | 39 | None | -8 | 25 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | ||
| DB00604 | 929 | 39 | None | -8 | 25 | Rat | 7.3 | pED50 | = | 7.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm00086a019 | ||
| 15095972 | 137007 | 0 | None | - | 0 | Rat | 7.2 | pED50 | = | 7.2 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| CHEMBL37544 | 137007 | 0 | None | - | 0 | Rat | 7.2 | pED50 | = | 7.2 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN2CCCC12 | 10.1021/jm00086a019 | ||
| 9864179 | 120827 | 0 | None | - | 0 | Guinea pig | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 370 | 6 | 0 | 5 | 4.1 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL358119 | 120827 | 0 | None | - | 0 | Guinea pig | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 370 | 6 | 0 | 5 | 4.1 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1021/jm00024a002 | ||
| 9864179 | 120827 | 0 | None | - | 0 | Guinea pig | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 370 | 6 | 0 | 5 | 4.1 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| CHEMBL358119 | 120827 | 0 | None | - | 0 | Guinea pig | 10.6 | pIC50 | = | 10.6 | Binding | ChEMBL | 370 | 6 | 0 | 5 | 4.1 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| 54575167 | 151488 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 454 | 8 | 2 | 5 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccc3ccccc32)CC1 | nan | ||
| CHEMBL3967117 | 151488 | 0 | None | - | 0 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 454 | 8 | 2 | 5 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccc3ccccc32)CC1 | nan | ||
| 54575171 | 149520 | 1 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1 | nan | ||
| CHEMBL3950712 | 149520 | 1 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1 | nan | ||
| 54575225 | 147466 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 440 | 6 | 2 | 5 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cn(C)c3ccccc23)CC1 | nan | ||
| CHEMBL3934371 | 147466 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 440 | 6 | 2 | 5 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cn(C)c3ccccc23)CC1 | nan | ||
| 121881 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1021/jm00024a002 | ||
| 256 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1021/jm00024a002 | ||
| CHEMBL68131 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1021/jm00024a002 | ||
| 121881 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/S0960-894X(01)80176-1 | ||
| 256 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/S0960-894X(01)80176-1 | ||
| CHEMBL68131 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/S0960-894X(01)80176-1 | ||
| 10617443 | 33810 | 0 | None | - | 0 | Guinea pig | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 344 | 7 | 1 | 4 | 3.8 | CCCCN1CCC(COC(=O)c2c(OC)[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL142490 | 33810 | 0 | None | - | 0 | Guinea pig | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 344 | 7 | 1 | 4 | 3.8 | CCCCN1CCC(COC(=O)c2c(OC)[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| 10736989 | 36638 | 0 | None | - | 0 | Guinea pig | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 356 | 6 | 0 | 5 | 3.7 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCO3)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL145075 | 36638 | 0 | None | - | 0 | Guinea pig | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 356 | 6 | 0 | 5 | 3.7 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCO3)CC1 | 10.1021/jm00024a002 | ||
| 10736989 | 36638 | 0 | None | - | 0 | Guinea pig | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 356 | 6 | 0 | 5 | 3.7 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCO3)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| CHEMBL145075 | 36638 | 0 | None | - | 0 | Guinea pig | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 356 | 6 | 0 | 5 | 3.7 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCO3)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| 54575170 | 146443 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 434 | 10 | 2 | 7 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccnn2)CC1 | nan | ||
| CHEMBL3926377 | 146443 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 434 | 10 | 2 | 7 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccnn2)CC1 | nan | ||
| 54575227 | 141985 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 405 | 6 | 2 | 4 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(F)cc2)CC1 | nan | ||
| CHEMBL3890747 | 141985 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 405 | 6 | 2 | 4 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(F)cc2)CC1 | nan | ||
| 10691444 | 35257 | 0 | None | - | 0 | Guinea pig | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 384 | 6 | 0 | 5 | 4.5 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCCO3)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL143862 | 35257 | 0 | None | - | 0 | Guinea pig | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 384 | 6 | 0 | 5 | 4.5 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCCO3)CC1 | 10.1021/jm00024a002 | ||
| 10691444 | 35257 | 0 | None | - | 0 | Guinea pig | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 384 | 6 | 0 | 5 | 4.5 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCCO3)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| CHEMBL143862 | 35257 | 0 | None | - | 0 | Guinea pig | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 384 | 6 | 0 | 5 | 4.5 | CCCCN1CCC(COC(=O)c2c3n(c4ccccc24)CCCCO3)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| 54575166 | 153795 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 407 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cnnn2)CC1 | nan | ||
| CHEMBL3986866 | 153795 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 407 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cnnn2)CC1 | nan | ||
| 54575223 | 150309 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2nccn2)CC1 | nan | ||
| CHEMBL3957180 | 150309 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2nccn2)CC1 | nan | ||
| 66780300 | 148924 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cncn2)CC1 | nan | ||
| CHEMBL3946162 | 148924 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 406 | 8 | 2 | 7 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cncn2)CC1 | nan | ||
| 54575168 | 146649 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 419 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnc2C)CC1 | nan | ||
| CHEMBL3928124 | 146649 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 419 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnc2C)CC1 | nan | ||
| 54575224 | 153276 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 388 | 6 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccnc2)CC1 | nan | ||
| CHEMBL3982522 | 153276 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 388 | 6 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccnc2)CC1 | nan | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 54575228 | 145642 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 403 | 6 | 3 | 5 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(O)cc2)CC1 | nan | ||
| CHEMBL3920018 | 145642 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 403 | 6 | 3 | 5 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(O)cc2)CC1 | nan | ||
| 53472864 | 145024 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 390 | 6 | 2 | 5 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccn2C)CC1 | nan | ||
| CHEMBL3915236 | 145024 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 390 | 6 | 2 | 5 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccn2C)CC1 | nan | ||
| 54575226 | 144444 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 377 | 6 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ncc[nH]2)CC1 | nan | ||
| CHEMBL3910849 | 144444 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 377 | 6 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ncc[nH]2)CC1 | nan | ||
| 10852772 | 34886 | 1 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 314 | 6 | 1 | 3 | 3.8 | CCCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL143426 | 34886 | 1 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 314 | 6 | 1 | 3 | 3.8 | CCCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| 10852772 | 34886 | 1 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 314 | 6 | 1 | 3 | 3.8 | CCCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| CHEMBL143426 | 34886 | 1 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 314 | 6 | 1 | 3 | 3.8 | CCCCN1CCC(COC(=O)c2c[nH]c3ccccc23)CC1 | 10.1016/S0960-894X(01)80176-1 | ||
| 9881053 | 119727 | 0 | None | - | 1 | Mouse | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.1 | CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL35226 | 119727 | 0 | None | - | 1 | Mouse | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.1 | CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| 90666907 | 108950 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 467 | 7 | 1 | 8 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2-c2cnccn2)CC1 | 10.1039/C1MD00213A | ||
| CHEMBL3220223 | 108950 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 467 | 7 | 1 | 8 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2-c2cnccn2)CC1 | 10.1039/C1MD00213A | ||
| 44300153 | 195800 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC1CN2C | 10.1016/s0960-894x(01)00693-x | ||
| CHEMBL56994 | 195800 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC1CN2C | 10.1016/s0960-894x(01)00693-x | ||
| 44300154 | 196711 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC1N(C)C2 | 10.1016/s0960-894x(01)00693-x | ||
| CHEMBL57686 | 196711 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC1N(C)C2 | 10.1016/s0960-894x(01)00693-x | ||
| 3245407 | 47826 | 23 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 212 | 1 | 2 | 1 | 2.9 | Cc1[nH]c2ccccc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | ||
| CHEMBL1550957 | 47826 | 23 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 212 | 1 | 2 | 1 | 2.9 | Cc1[nH]c2ccccc2c1C1=CCNCC1 | 10.1016/j.ejmech.2013.03.006 | ||
| 10590554 | 206630 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 303 | 3 | 2 | 5 | 0.1 | CN1CCN(CCNC(=O)n2c(=O)[nH]c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL99577 | 206630 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 303 | 3 | 2 | 5 | 0.1 | CN1CCN(CCNC(=O)n2c(=O)[nH]c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 155525723 | 170509 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4457426 | 170509 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| 176155 | 4086 | 0 | None | -1 | 4 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 377 | 4 | 1 | 3 | 4.7 | C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 | nan | ||
| CHEMBL10 | 4086 | 0 | None | -1 | 4 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 377 | 4 | 1 | 3 | 4.7 | C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 | nan | ||
| 2585 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| 522 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| 551 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| CHEMBL723 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| DB01136 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| 44385634 | 61764 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 465 | 10 | 3 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL177573 | 61764 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 465 | 10 | 3 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 90644473 | 111775 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 2.7 | COc1cc2c3c(cccc3n1)C(=O)N(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291078 | 111775 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 2.7 | COc1cc2c3c(cccc3n1)C(=O)N(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| 127027374 | 137129 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 423 | 8 | 2 | 9 | 0.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ncnn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758523 | 137129 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 423 | 8 | 2 | 9 | 0.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ncnn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1016/s0960-894x(02)00060-4 | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1016/s0960-894x(02)00060-4 | ||
| 242 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1016/s0960-894x(02)00060-4 | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1016/s0960-894x(02)00060-4 | ||
| 2274 | 3112 | 53 | None | -17 | 32 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 4917 | 3112 | 53 | None | -17 | 32 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 7279 | 3112 | 53 | None | -17 | 32 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| CHEMBL728 | 3112 | 53 | None | -17 | 32 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| DB00433 | 3112 | 53 | None | -17 | 32 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 127027397 | 137092 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758199 | 137092 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 421 | 8 | 2 | 7 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2ccnc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 68592173 | 137303 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759944 | 137303 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 31703 | 193040 | 59 | None | 1 | 3 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | ||
| CHEMBL359744 | 193040 | 59 | None | 1 | 3 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | ||
| CHEMBL53463 | 193040 | 59 | None | 1 | 3 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | ||
| 68593479 | 137261 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759601 | 137261 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 422 | 8 | 2 | 8 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cncn2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 44214754 | 60065 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 437 | 8 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL174935 | 60065 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 437 | 8 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 68592826 | 137143 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 496 | 8 | 2 | 7 | 3.0 | CCCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758641 | 137143 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 496 | 8 | 2 | 7 | 3.0 | CCCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 25016328 | 137287 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759860 | 137287 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 3397 | 203767 | 104 | None | 1 | 2 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 276 | 3 | 1 | 3 | 3.2 | CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 | nan | ||
| CHEMBL806 | 203767 | 104 | None | 1 | 2 | Guinea pig | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 276 | 3 | 1 | 3 | 3.2 | CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 | nan | ||
| 44384769 | 130828 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 451 | 8 | 3 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CC(C)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL368844 | 130828 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 451 | 8 | 3 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CC(C)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44386218 | 165583 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 7 | 3 | 6 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL426216 | 165583 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 7 | 3 | 6 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44386168 | 167708 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 453 | 8 | 4 | 7 | 1.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CC(O)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL433984 | 167708 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 453 | 8 | 4 | 7 | 1.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CC(O)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 155565664 | 175020 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4580044 | 175020 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| 16005860 | 186813 | 6 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 | 10.1021/jm800830n | ||
| CHEMBL493677 | 186813 | 6 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 388 | 5 | 1 | 2 | 4.8 | CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 | 10.1021/jm800830n | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm970376w | ||
| 441383 | 20118 | 54 | None | -5 | 17 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | ||
| CHEMBL1306 | 20118 | 54 | None | -5 | 17 | Guinea pig | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | ||
| 10784420 | 120492 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 355 | 6 | 1 | 4 | 3.3 | CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCO3)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL356546 | 120492 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 355 | 6 | 1 | 4 | 3.3 | CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCO3)CC1 | 10.1021/jm00024a002 | ||
| 87509467 | 137145 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=S)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758674 | 137145 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=S)C(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 1043 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 149 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 8223 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| CHEMBL442 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| DB00696 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 10645984 | 18614 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1039/C1MD00213A | ||
| CHEMBL127876 | 18614 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1039/C1MD00213A | ||
| 133 | 2450 | 48 | None | -79 | 43 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 1723 | 2450 | 48 | None | -79 | 43 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 28693 | 2450 | 48 | None | -79 | 43 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| CHEMBL19215 | 2450 | 48 | None | -79 | 43 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| DB13520 | 2450 | 48 | None | -79 | 43 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 10645103 | 163778 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1039/C1MD00213A | ||
| CHEMBL421256 | 163778 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1039/C1MD00213A | ||
| 68593295 | 137249 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759546 | 137249 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 10669778 | 116959 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1039/C1MD00213A | ||
| CHEMBL339936 | 116959 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1039/C1MD00213A | ||
| 3019427 | 60048 | 27 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL1748 | 60048 | 27 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 313 | 4 | 3 | 5 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1OC | 10.1016/j.bmcl.2009.08.016 | ||
| 68593458 | 137305 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 6 | 2 | 7 | 2.2 | COC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759969 | 137305 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 6 | 2 | 7 | 2.2 | COC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 90644474 | 111776 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 343 | 4 | 0 | 3 | 3.7 | O=C1c2cc(Cl)nc3cccc(c23)CN1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291079 | 111776 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 343 | 4 | 0 | 3 | 3.7 | O=C1c2cc(Cl)nc3cccc(c23)CN1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| 10591304 | 38190 | 2 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 313 | 6 | 2 | 2 | 3.4 | CCCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL146386 | 38190 | 2 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 313 | 6 | 2 | 2 | 3.4 | CCCCN1CCC(CNC(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| 44384896 | 59959 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 479 | 7 | 3 | 6 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(N)C(C)C)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL174284 | 59959 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 479 | 7 | 3 | 6 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(N)C(C)C)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44384728 | 59499 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 479 | 8 | 3 | 6 | 2.5 | CCCC(N)C(=O)N1CCC(CN2CCC(NC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL172802 | 59499 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 479 | 8 | 3 | 6 | 2.5 | CCCC(N)C(=O)N1CCC(CN2CCC(NC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44384721 | 130130 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 465 | 6 | 3 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(C)(C)N)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL368213 | 130130 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 465 | 6 | 3 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(C)(C)N)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 90644470 | 111773 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 3.3 | COc1cc(C(=O)OCCCN2CCCCC2)c2ccccc2n1 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291075 | 111773 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 3.3 | COc1cc(C(=O)OCCCN2CCCCC2)c2ccccc2n1 | 10.1016/j.ejmech.2014.05.015 | ||
| 44385584 | 129650 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 515 | 10 | 3 | 7 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCNS(C)(=O)=O)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL367877 | 129650 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 515 | 10 | 3 | 7 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCNS(C)(=O)=O)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 2353 | 100630 | 75 | None | -1 | 5 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.1 | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 | nan | ||
| CHEMBL12089 | 100630 | 75 | None | -1 | 5 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.1 | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 | nan | ||
| CHEMBL295124 | 100630 | 75 | None | -1 | 5 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.1 | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 | nan | ||
| 4223 | 3917 | 88 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
| 6918314 | 3917 | 88 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
| 7427 | 3917 | 88 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
| CHEMBL439849 | 3917 | 88 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
| DB06684 | 3917 | 88 | None | - | 3 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 7 | 2 | 5 | 4.0 | N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2 | 10.1021/jm040793q | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 10550242 | 17060 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1039/C1MD00213A | ||
| CHEMBL125670 | 17060 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1039/C1MD00213A | ||
| 11796362 | 114590 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1039/C1MD00213A | ||
| CHEMBL334325 | 114590 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1039/C1MD00213A | ||
| 44384735 | 59579 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 479 | 9 | 3 | 6 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CCCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL173089 | 59579 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 479 | 9 | 3 | 6 | 2.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CCCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44384689 | 59308 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 3 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL172074 | 59308 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 3 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| 260 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| 2775 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| 656665 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| CHEMBL56564 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| DB11699 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| 68592299 | 137216 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759259 | 137216 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 68593622 | 137115 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 7 | 2 | 7 | 2.6 | CCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758398 | 137115 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 7 | 2 | 7 | 2.6 | CCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 3168 | 9157 | 84 | None | -93 | 22 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| CHEMBL1108 | 9157 | 84 | None | -93 | 22 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| 44626295 | 196087 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL571799 | 196087 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| 44385532 | 60940 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 4 | 7 | 1.2 | COc1cc(N)c(Cl)cc1C(=O)NCC(O)CN1CCC(CN2CCC(N)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL176672 | 60940 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 4 | 7 | 1.2 | COc1cc(N)c(Cl)cc1C(=O)NCC(O)CN1CCC(CN2CCC(N)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44384630 | 128483 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 479 | 7 | 3 | 6 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C(=O)C2CCN(C(=O)CCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL366986 | 128483 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 479 | 7 | 3 | 6 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C(=O)C2CCN(C(=O)CCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 12 | 1518 | 14 | None | - | 7 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1016/j.bmcl.2005.06.067 | ||
| 6918513 | 1518 | 14 | None | - | 7 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1016/j.bmcl.2005.06.067 | ||
| CHEMBL267615 | 1518 | 14 | None | - | 7 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1016/j.bmcl.2005.06.067 | ||
| 90644475 | 111777 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 3.4 | O=C1c2cccc3nc(Cl)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291080 | 111777 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 3.4 | O=C1c2cccc3nc(Cl)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| 45485653 | 195897 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL570487 | 195897 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@]2(O)CCCC[C@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| 5311047 | 203045 | 30 | None | -5 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL74656 | 203045 | 30 | None | -5 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 182593 | 3331 | 4 | None | 1 | 3 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | ||
| 254 | 3331 | 4 | None | 1 | 3 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL83954 | 3331 | 4 | None | 1 | 3 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | ||
| 107715 | 199250 | 18 | None | -165 | 20 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | ||
| CHEMBL1255837 | 199250 | 18 | None | -165 | 20 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | ||
| CHEMBL601773 | 199250 | 18 | None | -165 | 20 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | ||
| 68593871 | 137226 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759348 | 137226 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 2.4 | CCC(=O)N1CCCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)C1 | 10.1016/j.ejmech.2015.12.006 | ||
| 44384684 | 59527 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 6 | 3 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(C)N)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL172899 | 59527 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 6 | 3 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(C)N)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44384624 | 165423 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 7 | 3 | 6 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(C)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL425329 | 165423 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 7 | 3 | 6 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)C(C)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 45485563 | 196113 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 475 | 9 | 3 | 6 | 3.7 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN(C)CCNC(=O)c2cc(Cl)c(N)cc2OC)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL572038 | 196113 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 475 | 9 | 3 | 6 | 3.7 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN(C)CCNC(=O)c2cc(Cl)c(N)cc2OC)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| 68592632 | 137277 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 481 | 6 | 2 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)N(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759759 | 137277 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 481 | 6 | 2 | 6 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)N(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 67922794 | 137182 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758945 | 137182 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 68593774 | 137155 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 7 | 2 | 6 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758721 | 137155 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 7 | 2 | 6 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 68591735 | 137228 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 6 | 2 | 6 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(C)=O)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759362 | 137228 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 6 | 2 | 6 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(C)=O)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 87509988 | 137114 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 3.2 | CCC(=S)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758397 | 137114 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 3.2 | CCC(=S)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 9911674 | 130900 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 451 | 9 | 3 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL369037 | 130900 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 451 | 9 | 3 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(CCCCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 45485620 | 195734 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL569585 | 195734 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 531 | 8 | 3 | 7 | 3.8 | COc1cccc([C@@]2(O)CCCC[C@@H]2CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)c1 | 10.1016/j.bmcl.2009.08.016 | ||
| 10131112 | 1517 | 21 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | ||
| 8428 | 1517 | 21 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | ||
| CHEMBL364005 | 1517 | 21 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 246 | 1 | 2 | 1 | 3.5 | Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C | 10.1016/j.bmcl.2005.06.067 | ||
| 10812045 | 15331 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1039/C1MD00213A | ||
| CHEMBL121766 | 15331 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1039/C1MD00213A | ||
| 68592484 | 137180 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758932 | 137180 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 420 | 8 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCn2cccc2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 127027375 | 137302 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759928 | 137302 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCC(Cc3ccccc3)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 25016330 | 137105 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758309 | 137105 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CC2CCN(C(=O)C(C)C)CC2)C[C@@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 155543353 | 172719 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4526049 | 172719 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| 10620001 | 33963 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 383 | 6 | 1 | 4 | 4.1 | CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCCO3)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL142621 | 33963 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 383 | 6 | 1 | 4 | 4.1 | CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCCO3)CC1 | 10.1021/jm00024a002 | ||
| 10717193 | 16588 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1039/C1MD00213A | ||
| CHEMBL124485 | 16588 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1039/C1MD00213A | ||
| 68592631 | 137186 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 495 | 7 | 3 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)NC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758976 | 137186 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 495 | 7 | 3 | 6 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)NC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 3157 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| 7170 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| 954 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| CHEMBL707 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| DB00590 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| 68593153 | 137121 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)CC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758433 | 137121 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CC2CCN(C(=O)CC(C)C)CC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 10545343 | 164323 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 343 | 7 | 2 | 3 | 3.4 | CCCCN1CCC(CNC(=O)c2c(OC)[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| CHEMBL422116 | 164323 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 343 | 7 | 2 | 3 | 3.4 | CCCCN1CCC(CNC(=O)c2c(OC)[nH]c3ccccc23)CC1 | 10.1021/jm00024a002 | ||
| 151537 | 162102 | 43 | None | - | 1 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | nan | ||
| 41867 | 162102 | 43 | None | - | 1 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | nan | ||
| CHEMBL417 | 162102 | 43 | None | - | 1 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | nan | ||
| 5991 | 202212 | 68 | None | 2 | 5 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 296 | 0 | 2 | 2 | 3.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C | nan | ||
| CHEMBL691 | 202212 | 68 | None | 2 | 5 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 296 | 0 | 2 | 2 | 3.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C | nan | ||
| 68593732 | 137285 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCC(=O)N1CCC(CCN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3759824 | 137285 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CCC(=O)N1CCC(CCN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@H](OC)C2)CC1 | 10.1016/j.ejmech.2015.12.006 | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| 242 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| 44384672 | 59375 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 437 | 6 | 3 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL172314 | 59375 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 437 | 6 | 3 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 44384738 | 60012 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 451 | 7 | 3 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| CHEMBL174524 | 60012 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 451 | 7 | 3 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CC2CCN(C(=O)CCN)CC2)CC1 | 10.1016/s0960-894x(02)00060-4 | ||
| 1782 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| 241 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| 4168 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| CHEMBL86 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| DB01233 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| 90644472 | 111774 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.1 | COc1cc2c3c(cccc3n1)CN(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291077 | 111774 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.1 | COc1cc2c3c(cccc3n1)CN(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| 127028946 | 137136 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758578 | 137136 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 10531 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 121 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 888 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| CHEMBL1732 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| DB00320 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 127027702 | 137118 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCOCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| CHEMBL3758410 | 137118 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCC(=O)N2CCOCC2)C[C@H]1OC | 10.1016/j.ejmech.2015.12.006 | ||
| 3066250 | 69928 | 2 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | ||
| CHEMBL194305 | 69928 | 2 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 242 | 2 | 2 | 2 | 2.9 | COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1 | 10.1016/j.bmcl.2005.06.067 | ||
| 44626294 | 197311 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | ||
| CHEMBL585567 | 197311 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 517 | 7 | 4 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(C[C@@H]2CCCC[C@@]2(O)c2cccc(O)c2)C[C@H]1OC | 10.1016/j.bmcl.2009.08.016 | ||
| 121881 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.7 | pKd | = | 10.7 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | ||
| 256 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.7 | pKd | = | 10.7 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | ||
| CHEMBL68131 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.7 | pKd | = | 10.7 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | ||
| 257 | 3424 | 9 | None | -1 | 4 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | ||
| 5311423 | 3424 | 9 | None | -1 | 4 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | ||
| CHEMBL114112 | 3424 | 9 | None | -1 | 4 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1016/j.bmcl.2013.09.097 | ||
| 76310958 | 105234 | 1 | None | -1 | 2 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1016/j.bmcl.2013.09.097 | ||
| CHEMBL3126112 | 105234 | 1 | None | -1 | 2 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1016/j.bmcl.2013.09.097 | ||
| CHEMBL5182119 | 105234 | 1 | None | -1 | 2 | Rat | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1016/j.bmcl.2013.09.097 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/np0601760 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/np0601760 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/np0601760 | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/acs.jmedchem.2c00633 | ||
| 121881 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/S0960-894X(01)80414-5 | ||
| 256 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL68131 | 3421 | 21 | None | 2 | 15 | Guinea pig | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/S0960-894X(01)80414-5 | ||
| 121881 | 3421 | 21 | None | -2 | 15 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmc.2008.11.045 | ||
| 256 | 3421 | 21 | None | -2 | 15 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL68131 | 3421 | 21 | None | -2 | 15 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10.1016/j.bmc.2008.11.045 | ||
| 9936969 | 63788 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 2.2 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL180835 | 63788 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 2.2 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 44390256 | 63993 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 522 | 10 | 1 | 7 | 2.0 | CCC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL181202 | 63993 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 522 | 10 | 1 | 7 | 2.0 | CCC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 9914629 | 122586 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 519 | 8 | 1 | 6 | 3.3 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCC3(CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL361118 | 122586 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 519 | 8 | 1 | 6 | 3.3 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCC3(CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 9870916 | 63976 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 10 | 1 | 7 | 1.6 | CCCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL181126 | 63976 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 10 | 1 | 7 | 1.6 | CCCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 9892494 | 65122 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 1.6 | CC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL182999 | 65122 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 1.6 | CC(C)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 9873926 | 129121 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL367354 | 129121 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.ejmech.2013.03.060 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.ejmech.2013.03.060 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.ejmech.2013.03.060 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2013.09.004 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2013.09.004 | ||
| 71455625 | 82537 | 0 | None | 54 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181170 | 82537 | 0 | None | 54 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 71455625 | 82537 | 0 | None | 54 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL2181170 | 82537 | 0 | None | 54 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| 71455625 | 82537 | 0 | None | 54 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181170 | 82537 | 0 | None | 54 | 6 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 53325605 | 56138 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 489 | 9 | 1 | 6 | 4.4 | O=C(CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632165 | 56138 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 489 | 9 | 1 | 6 | 4.4 | O=C(CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | ||
| 46935636 | 102086 | 0 | None | 31622 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440460 | 102086 | 0 | None | 31622 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL3040772 | 102086 | 0 | None | 31622 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | ||
| 118712571 | 113721 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 538 | 9 | 2 | 6 | 4.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329805 | 113721 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 538 | 9 | 2 | 6 | 4.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| 9807895 | 63604 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 560 | 9 | 1 | 7 | 2.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL180680 | 63604 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 560 | 9 | 1 | 7 | 2.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccc(F)cc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 9870390 | 165228 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 1.3 | CCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL424790 | 165228 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 1.3 | CCN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2010.10.011 | ||
| 50898776 | 56136 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 483 | 9 | 1 | 6 | 4.8 | CC(C)(C)OC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632163 | 56136 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 483 | 9 | 1 | 6 | 4.8 | CC(C)(C)OC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 46935596 | 92430 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 5.5 | COC(=O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440457 | 92430 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 5.5 | COC(=O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | ||
| 9892465 | 63443 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 507 | 10 | 1 | 6 | 3.1 | CCCC1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL180201 | 63443 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 507 | 10 | 1 | 6 | 3.1 | CCCC1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 50898699 | 56141 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 541 | 11 | 1 | 8 | 4.5 | CC(C)(C)C(=O)OCOC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632169 | 56141 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 541 | 11 | 1 | 8 | 4.5 | CC(C)(C)C(=O)OCOC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 72545050 | 105232 | 0 | None | - | 1 | Rat | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 386 | 6 | 1 | 6 | 2.9 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | ||
| CHEMBL3126108 | 105232 | 0 | None | - | 1 | Rat | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 386 | 6 | 1 | 6 | 2.9 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 9954930 | 84148 | 0 | None | 398 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2177130 | 84148 | 0 | None | 398 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2220969 | 84148 | 0 | None | 398 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 91754444 | 113730 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 388 | 6 | 2 | 7 | 1.6 | O=C(OCC1CCN(CC(O)CO)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329814 | 113730 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 388 | 6 | 2 | 7 | 1.6 | O=C(OCC1CCN(CC(O)CO)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| 21268036 | 122206 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 0.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)N3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL360449 | 122206 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 0.6 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(S(=O)(=O)N3CCCC3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 90667897 | 109029 | 0 | None | - | 1 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 4.0 | CCCCN1CCC(CNC(=S)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| CHEMBL3221572 | 109029 | 0 | None | - | 1 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 364 | 6 | 2 | 3 | 4.0 | CCCCN1CCC(CNC(=S)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 250 | 3322 | 5 | None | -2 | 13 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 10.1016/0960-894X(95)00358-Z | ||
| 5311416 | 3322 | 5 | None | -2 | 13 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 10.1016/0960-894X(95)00358-Z | ||
| CHEMBL69733 | 3322 | 5 | None | -2 | 13 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 10.1016/0960-894X(95)00358-Z | ||
| 11153975 | 84129 | 4 | None | 1000 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 3.7 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccn3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179697 | 84129 | 4 | None | 1000 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 3.7 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccn3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2220892 | 84129 | 4 | None | 1000 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 3.7 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccn3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.ejmech.2013.03.060 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| 21268033 | 63782 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 560 | 9 | 1 | 8 | 1.7 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C(=O)c3ccco3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL180830 | 63782 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 560 | 9 | 1 | 8 | 1.7 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(C(=O)c3ccco3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 15485936 | 122079 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 572 | 11 | 1 | 8 | 1.0 | CCCS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL360245 | 122079 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 572 | 11 | 1 | 8 | 1.0 | CCCS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 53319410 | 56130 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 427 | 8 | 1 | 6 | 3.2 | CCOC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632157 | 56130 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 427 | 8 | 1 | 6 | 3.2 | CCOC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 50898777 | 56131 | 0 | None | 2951 | 8 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.6 | COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632158 | 56131 | 0 | None | 2951 | 8 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 3.6 | COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 10476858 | 111859 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL329487 | 111859 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 119376 | 1803 | 41 | None | 1 | 27 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm981098j | ||
| 247 | 1803 | 41 | None | 1 | 27 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm981098j | ||
| CHEMBL33884 | 1803 | 41 | None | 1 | 27 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm981098j | ||
| 10476858 | 111859 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL329487 | 111859 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 72698087 | 103498 | 0 | None | 81 | 3 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 5.0 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL3093186 | 103498 | 0 | None | 81 | 3 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 5.0 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| 10476858 | 111859 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL329487 | 111859 | 0 | None | - | 1 | Rat | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 413 | 7 | 3 | 5 | 1.2 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 46935743 | 90376 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.9 | CC(C)(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.ejmech.2013.03.060 | ||
| CHEMBL2391994 | 90376 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.9 | CC(C)(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.ejmech.2013.03.060 | ||
| 21268037 | 62252 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 493 | 8 | 1 | 6 | 2.7 | CC1(C)CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL178285 | 62252 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 493 | 8 | 1 | 6 | 2.7 | CC1(C)CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 21268031 | 62655 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 0.8 | CC(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL178669 | 62655 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 508 | 8 | 1 | 7 | 0.8 | CC(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 44390214 | 63121 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 572 | 10 | 1 | 8 | 1.0 | CC(C)S(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL179833 | 63121 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 572 | 10 | 1 | 8 | 1.0 | CC(C)S(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 9952994 | 106474 | 0 | None | - | 1 | Rat | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL315071 | 106474 | 0 | None | - | 1 | Rat | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 366 | 6 | 1 | 5 | 3.5 | CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| 50898775 | 56139 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 517 | 11 | 1 | 6 | 5.2 | O=C(CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632167 | 56139 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 517 | 11 | 1 | 6 | 5.2 | O=C(CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCc1ccccc1 | 10.1016/j.bmc.2010.10.011 | ||
| 119376 | 1803 | 41 | None | -2 | 27 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960853v | ||
| 247 | 1803 | 41 | None | -2 | 27 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960853v | ||
| CHEMBL33884 | 1803 | 41 | None | -2 | 27 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960853v | ||
| 119376 | 1803 | 41 | None | -2 | 27 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | ||
| 247 | 1803 | 41 | None | -2 | 27 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | ||
| CHEMBL33884 | 1803 | 41 | None | -2 | 27 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm960320m | ||
| 90667896 | 109028 | 0 | None | - | 1 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 330 | 6 | 2 | 3 | 3.3 | CCCCN1CCC(CNC(=S)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| CHEMBL3221571 | 109028 | 0 | None | - | 1 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 330 | 6 | 2 | 3 | 3.3 | CCCCN1CCC(CNC(=S)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2008.11.045 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmc.2008.11.045 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm300573d | ||
| 21252894 | 84159 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 5.0 | CC(C)n1nc(C(=O)NCC2CCN(CCC3CCCCC3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179699 | 84159 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 5.0 | CC(C)n1nc(C(=O)NCC2CCN(CCC3CCCCC3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2221066 | 84159 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 410 | 7 | 1 | 4 | 5.0 | CC(C)n1nc(C(=O)NCC2CCN(CCC3CCCCC3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 11317280 | 63632 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 0.5 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCNCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL180697 | 63632 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 0.5 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCNCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 44390243 | 64138 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 557 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(Cc3cccnc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL181415 | 64138 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 557 | 10 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(Cc3cccnc3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 11493559 | 73051 | 0 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL201621 | 73051 | 0 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 44407083 | 73547 | 0 | None | 6 | 2 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 284 | 3 | 1 | 3 | 2.8 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12 | 10.1021/jm0509501 | ||
| CHEMBL201946 | 73547 | 0 | None | 6 | 2 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 284 | 3 | 1 | 3 | 2.8 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12 | 10.1021/jm0509501 | ||
| 53317702 | 56132 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 497 | 13 | 1 | 6 | 5.2 | COC(=O)CCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632159 | 56132 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 497 | 13 | 1 | 6 | 5.2 | COC(=O)CCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 9823412 | 84173 | 0 | None | 398 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 7 | 2 | 5 | 3.9 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2221193 | 84173 | 0 | None | 398 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 7 | 2 | 5 | 3.9 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL3216126 | 84173 | 0 | None | 398 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 7 | 2 | 5 | 3.9 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 118712569 | 113719 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329803 | 113719 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.4 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| 118712572 | 113722 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 564 | 8 | 2 | 6 | 5.1 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329806 | 113722 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 564 | 8 | 2 | 6 | 5.1 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| 118712573 | 113723 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 459 | 7 | 2 | 6 | 2.5 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329807 | 113723 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 459 | 7 | 2 | 6 | 2.5 | CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| 118712575 | 113725 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 501 | 9 | 2 | 6 | 3.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329809 | 113725 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 501 | 9 | 2 | 6 | 3.5 | CC(C)CS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| 44390192 | 64425 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 2.1 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCCCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL181928 | 64425 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 2.1 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCCCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 72698088 | 103499 | 0 | None | 20 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 5.4 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL3093187 | 103499 | 0 | None | 20 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 5.4 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| 72545049 | 105233 | 0 | None | - | 1 | Rat | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.5 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | ||
| CHEMBL3126109 | 105233 | 0 | None | - | 1 | Rat | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.5 | Nc1c(Cl)cc(C(=O)OCC2CCN(CCF)CC2)c2c1OCCO2 | 10.1016/j.bmcl.2013.09.097 | ||
| 257 | 3424 | 9 | None | 1 | 4 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 5311423 | 3424 | 9 | None | 1 | 4 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| CHEMBL114112 | 3424 | 9 | None | 1 | 4 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 49783421 | 17591 | 0 | None | 51 | 2 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 352 | 9 | 1 | 5 | 3.3 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258786 | 17591 | 0 | None | 51 | 2 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 352 | 9 | 1 | 5 | 3.3 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1 | 10.1021/jm100668r | ||
| 71459269 | 82533 | 0 | None | 10 | 8 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 555 | 7 | 0 | 4 | 6.3 | Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 | 10.1021/jm300943r | ||
| CHEMBL2181166 | 82533 | 0 | None | 10 | 8 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 555 | 7 | 0 | 4 | 6.3 | Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 | 10.1021/jm300943r | ||
| 53320711 | 56135 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.0 | CC(C)(C)OC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632162 | 56135 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.0 | CC(C)(C)OC(=O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 17984294 | 84171 | 0 | None | 39 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179704 | 84171 | 0 | None | 39 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2221162 | 84171 | 0 | None | 39 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmcl.2014.06.083 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1016/j.bmcl.2014.06.083 | ||
| 118712574 | 113724 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 501 | 10 | 2 | 6 | 3.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329808 | 113724 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 501 | 10 | 2 | 6 | 3.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2005.01.039 | ||
| 9869791 | 63580 | 12 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 0.9 | CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL180632 | 63580 | 12 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 0.9 | CN1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 44390227 | 122284 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 543 | 9 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccccn3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL360531 | 122284 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 543 | 9 | 1 | 8 | 1.8 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCN(c3ccccn3)CC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 10831066 | 188239 | 3 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| CHEMBL50660 | 188239 | 3 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| 249 | 2518 | 3 | None | -1 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 9905972 | 2518 | 3 | None | -1 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| CHEMBL155917 | 2518 | 3 | None | -1 | 2 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 71457409 | 82535 | 0 | None | 17 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181168 | 82535 | 0 | None | 17 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 71450132 | 82251 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179584 | 82251 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 358 | 8 | 0 | 5 | 4.7 | CCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| 10472977 | 96093 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL262950 | 96093 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 10472977 | 96093 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL262950 | 96093 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 71462651 | 82254 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179587 | 82254 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 360 | 9 | 0 | 5 | 4.8 | CCCCN1CCC(COc2noc3cccc(OCC(C)C)c23)CC1 | 10.1021/jm300953p | ||
| 10472977 | 96093 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL262950 | 96093 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 5 | 2 | 3 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 76310958 | 105234 | 1 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1021/acs.jmedchem.2c00633 | ||
| CHEMBL3126112 | 105234 | 1 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1021/acs.jmedchem.2c00633 | ||
| CHEMBL5182119 | 105234 | 1 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 340 | 3 | 1 | 6 | 2.2 | CN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1 | 10.1021/acs.jmedchem.2c00633 | ||
| 53354764 | 3003 | 30 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | -1 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 71712326 | 90941 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cc(Cl)cc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402896 | 90941 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cc(Cl)cc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 21252889 | 84139 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 421 | 8 | 2 | 6 | 1.6 | CC(C)n1nc(C(=O)NCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179702 | 84139 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 421 | 8 | 2 | 6 | 1.6 | CC(C)n1nc(C(=O)NCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2220908 | 84139 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 421 | 8 | 2 | 6 | 1.6 | CC(C)n1nc(C(=O)NCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 118712580 | 113729 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 4.7 | CC(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329813 | 113729 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 476 | 7 | 1 | 6 | 4.7 | CC(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| 44390250 | 63115 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 544 | 9 | 1 | 8 | 0.2 | CS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL179799 | 63115 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 544 | 9 | 1 | 8 | 0.2 | CS(=O)(=O)N1CCN(S(=O)(=O)CCCN2CCC(CNC(=O)c3cccc4c3OCCO4)CC2)CC1 | 10.1016/j.bmcl.2005.01.039 | ||
| 10089141 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL94880 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 10089141 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| CHEMBL94880 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 10089141 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94880 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 10089141 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94880 | 205828 | 0 | None | - | 1 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 49783419 | 17552 | 0 | None | 6 | 13 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258671 | 17552 | 0 | None | 6 | 13 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 49783420 | 17553 | 0 | None | 51 | 2 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 8 | 1 | 5 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258672 | 17553 | 0 | None | 51 | 2 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 8 | 1 | 5 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1 | 10.1021/jm100668r | ||
| 44461527 | 204055 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 567 | 14 | 2 | 8 | 4.1 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL82976 | 204055 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 567 | 14 | 2 | 8 | 4.1 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1016/S0960-894X(01)80414-5 | ||
| 53319411 | 56133 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 525 | 15 | 1 | 6 | 5.9 | COC(=O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632160 | 56133 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 525 | 15 | 1 | 6 | 5.9 | COC(=O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 53324684 | 56140 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 4.8 | CC(C)(C)C(=O)OCOC(=O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632168 | 56140 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 4.8 | CC(C)(C)C(=O)OCOC(=O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | ||
| 11496400 | 11688 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL1181946 | 11688 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| CHEMBL199866 | 11688 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 4 | 2 | 3 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CC[N@@+]2(C)CCC[C@@H]12 | 10.1021/jm0509501 | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 53357029 | 82256 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| CHEMBL2179589 | 82256 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 418 | 8 | 1 | 7 | 3.5 | CC(C)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| 11961293 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 8426 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402904 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| DB12725 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 10.1016/j.bmcl.2013.05.018 | ||
| 21252892 | 84137 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 2.4 | CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2220906 | 84137 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 2.4 | CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL3215681 | 84137 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 2.4 | CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmcl.2014.06.083 | ||
| 9912434 | 123322 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 467 | 8 | 1 | 7 | 1.0 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCOCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL362582 | 123322 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 467 | 8 | 1 | 7 | 1.0 | O=C(NCC1CCN(CCCS(=O)(=O)N2CCOCC2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 11522273 | 140801 | 0 | None | 6 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 299 | 3 | 0 | 5 | 2.2 | Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL383577 | 140801 | 0 | None | 6 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 299 | 3 | 0 | 5 | 2.2 | Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 145988201 | 166527 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 366 | 7 | 0 | 4 | 4.8 | CCCCN1CCC(COC(=O)c2cc(C3CC3)nc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| CHEMBL4289793 | 166527 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 366 | 7 | 0 | 4 | 4.8 | CCCCN1CCC(COC(=O)c2cc(C3CC3)nc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| 49783206 | 17380 | 0 | None | 74 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 373 | 6 | 1 | 7 | 2.6 | CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258108 | 17380 | 0 | None | 74 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 373 | 6 | 1 | 7 | 2.6 | CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 10.1021/jm300953p | ||
| 44461518 | 204218 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 567 | 13 | 1 | 8 | 4.1 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCN(C)S(C)(=O)=O)CC2)cc(OC)c1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL84294 | 204218 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 567 | 13 | 1 | 8 | 4.1 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCN(C)S(C)(=O)=O)CC2)cc(OC)c1 | 10.1016/S0960-894X(01)80414-5 | ||
| 19081854 | 104250 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 488 | 12 | 1 | 6 | 6.0 | CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OCc2cc(OC)cc(OC)c2)CC1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL310667 | 104250 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 488 | 12 | 1 | 6 | 6.0 | CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OCc2cc(OC)cc(OC)c2)CC1 | 10.1016/S0960-894X(01)80414-5 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 53357011 | 82247 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | ||
| CHEMBL2179580 | 82247 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 446 | 7 | 2 | 8 | 2.8 | O[C@@H]1CC[C@@H](Oc2cccc3onc(OCC4CCN(CC5(O)CCOCC5)CC4)c23)C1 | 10.1021/jm300953p | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| 71714540 | 90935 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402890 | 90935 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 506 | 9 | 3 | 7 | 0.5 | CCc1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71714541 | 90936 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402891 | 90936 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 520 | 9 | 3 | 7 | 1.1 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71714542 | 90937 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402892 | 90937 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 518 | 9 | 3 | 7 | 0.8 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(C5CC5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 66810955 | 90948 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402903 | 90948 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 475 | 7 | 2 | 5 | 2.8 | CC(C)c1nc2c(C(=O)NCC3CCN(CC4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1021/jm00024a002 | ||
| 71457299 | 84170 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 385 | 7 | 2 | 5 | 2.2 | CNC(=O)CCN1CCC(CNC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/jm300573d | ||
| CHEMBL2179703 | 84170 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 385 | 7 | 2 | 5 | 2.2 | CNC(=O)CCN1CCC(CNC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/jm300573d | ||
| CHEMBL2221161 | 84170 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 385 | 7 | 2 | 5 | 2.2 | CNC(=O)CCN1CCC(CNC(=O)c2nn(C(C)C)c3ccccc23)CC1 | 10.1021/jm300573d | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm0009538 | ||
| 44327645 | 206367 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL97955 | 206367 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 44327645 | 206367 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL97955 | 206367 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 44327645 | 206367 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL97955 | 206367 | 0 | None | - | 1 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 362 | 7 | 2 | 3 | 3.8 | CCCCCN1CCC(CNC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 49783209 | 17412 | 0 | None | 3 | 27 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258223 | 17412 | 0 | None | 3 | 27 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 145987934 | 166490 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 356 | 7 | 0 | 5 | 3.9 | CCCCN1CCC(COC(=O)c2cc(OC)nc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| CHEMBL4289073 | 166490 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 356 | 7 | 0 | 5 | 3.9 | CCCCN1CCC(COC(=O)c2cc(OC)nc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| 21252899 | 84150 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 390 | 6 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(Cc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179696 | 84150 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 390 | 6 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(Cc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2220973 | 84150 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 390 | 6 | 1 | 4 | 4.3 | CC(C)n1nc(C(=O)NCC2CCN(Cc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 72697441 | 92431 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 523 | 7 | 2 | 5 | 5.4 | O=C(O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440458 | 92431 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 523 | 7 | 2 | 5 | 5.4 | O=C(O)c1ccccc1-c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | ||
| 11014701 | 205885 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL95178 | 205885 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 11014701 | 205885 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL95178 | 205885 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 11014701 | 205885 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL95178 | 205885 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 392 | 6 | 2 | 3 | 3.6 | CCCCN1CCC(CNC(=O)c2cc(Br)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10.1021/jm070552t | ||
| 11580890 | 73583 | 0 | None | 4 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 302 | 3 | 1 | 3 | 2.9 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccc(F)cc12 | 10.1021/jm0509501 | ||
| CHEMBL202122 | 73583 | 0 | None | 4 | 2 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 302 | 3 | 1 | 3 | 2.9 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccc(F)cc12 | 10.1021/jm0509501 | ||
| 49783415 | 17481 | 0 | None | 3 | 13 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258452 | 17481 | 0 | None | 3 | 13 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| 71451951 | 82252 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179585 | 82252 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 372 | 8 | 0 | 5 | 5.0 | CCCCN1CCC(COc2noc3cccc(OC4CCCC4)c23)CC1 | 10.1021/jm300953p | ||
| 5145950 | 201785 | 4 | None | 5 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL586946 | 201785 | 4 | None | 5 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL66114 | 201785 | 4 | None | 5 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1016/S0960-894X(01)80414-5 | ||
| 53322003 | 56134 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 427 | 5 | 1 | 6 | 3.2 | CC(C)(C)OC(=O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632161 | 56134 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 427 | 5 | 1 | 6 | 3.2 | CC(C)(C)OC(=O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 71712327 | 90942 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402897 | 90942 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 490 | 8 | 2 | 6 | 1.7 | CC(C)c1nc2c(C(=O)NCC3CCN(CCN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 9886435 | 92427 | 0 | None | -1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.6 | CC(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440453 | 92427 | 0 | None | -1 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.6 | CC(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| 9886435 | 92427 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.6 | CC(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440453 | 92427 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.6 | CC(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| 68490431 | 82302 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179707 | 82302 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 448 | 8 | 2 | 5 | 4.0 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 21252902 | 84138 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NCC2CCN(CCCN(C)C)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179701 | 84138 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NCC2CCN(CCCN(C)C)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2220907 | 84138 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 3.0 | CC(C)n1nc(C(=O)NCC2CCN(CCCN(C)C)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 70694780 | 76048 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059582 | 76048 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 509 | 12 | 1 | 6 | 5.0 | COC[C@@H]1CCCN1CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 252 | 3278 | 1 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 44391713 | 3278 | 1 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| CHEMBL182590 | 3278 | 1 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2005.01.039 | ||
| 11508052 | 73474 | 0 | None | 4 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 285 | 3 | 1 | 4 | 2.2 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12 | 10.1021/jm0509501 | ||
| CHEMBL201878 | 73474 | 0 | None | 4 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 285 | 3 | 1 | 4 | 2.2 | O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12 | 10.1021/jm0509501 | ||
| 19081848 | 204140 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 502 | 13 | 1 | 6 | 6.4 | CCCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OCc2cc(OC)cc(OC)c2)CC1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL83755 | 204140 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 502 | 13 | 1 | 6 | 6.4 | CCCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OCc2cc(OC)cc(OC)c2)CC1 | 10.1016/S0960-894X(01)80414-5 | ||
| 145981672 | 165984 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 360 | 6 | 0 | 4 | 4.6 | CCCCN1CCC(COC(=O)c2cc(Cl)nc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| CHEMBL4279446 | 165984 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 360 | 6 | 0 | 4 | 4.6 | CCCCN1CCC(COC(=O)c2cc(Cl)nc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| 49783417 | 17517 | 0 | None | 18 | 2 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 306 | 6 | 1 | 5 | 2.6 | CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258560 | 17517 | 0 | None | 18 | 2 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 306 | 6 | 1 | 5 | 2.6 | CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| 9973683 | 119289 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCCC1 | 10.1021/jm960320m | ||
| CHEMBL348311 | 119289 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCCC1 | 10.1021/jm960320m | ||
| 10381762 | 49023 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)C1 | 10.1021/jm960320m | ||
| CHEMBL156349 | 49023 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)C1 | 10.1021/jm960320m | ||
| 44213662 | 204861 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL88973 | 204861 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.5 | Nc1c(Cl)cc(C(=O)OCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 118734523 | 118162 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 394 | 6 | 1 | 5 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417008 | 118162 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 394 | 6 | 1 | 5 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 71462650 | 82253 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179586 | 82253 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 372 | 9 | 0 | 5 | 4.9 | CCCCN1CCC(COc2noc3cccc(OCC4CCC4)c23)CC1 | 10.1021/jm300953p | ||
| 71712466 | 90796 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2401750 | 90796 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 439 | 6 | 2 | 4 | 3.4 | CC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 15295138 | 50774 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| CHEMBL157880 | 50774 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0307887 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0307887 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0307887 | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 118712570 | 113720 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 538 | 10 | 2 | 6 | 4.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329804 | 113720 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 538 | 10 | 2 | 6 | 4.6 | CCCCS(=O)(=O)Nc1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmcl.2014.06.083 | ||
| 70696825 | 76044 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059578 | 76044 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 479 | 10 | 1 | 5 | 5.4 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 70696826 | 76046 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059580 | 76046 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 467 | 11 | 1 | 5 | 5.2 | CC(C)N(C)CCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 255 | 3420 | 13 | None | 1 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 10.1021/jm960442e | ||
| 3272300 | 3420 | 13 | None | 1 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 10.1021/jm960442e | ||
| CHEMBL1255781 | 3420 | 13 | None | 1 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 10.1021/jm960442e | ||
| 10615668 | 186091 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| CHEMBL48836 | 186091 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| 10690483 | 49020 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 369 | 6 | 2 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(C)=O)CC1 | 10.1021/jm960320m | ||
| CHEMBL156348 | 49020 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 369 | 6 | 2 | 6 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(C)=O)CC1 | 10.1021/jm960320m | ||
| 235 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 5311299 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL286136 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 235 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960853v | ||
| 5311299 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960853v | ||
| CHEMBL286136 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960853v | ||
| 235 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 5311299 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| CHEMBL286136 | 2517 | 36 | None | 4 | 3 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 53320712 | 56143 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.3 | O=C(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632171 | 56143 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 2.3 | O=C(O)CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 71454555 | 79209 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| CHEMBL2115017 | 79209 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 320 | 6 | 1 | 4 | 3.6 | CCOc1ccccc1NC(=O)OCCN1C[C@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| 71462776 | 82536 | 0 | None | 11 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 460 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181169 | 82536 | 0 | None | 11 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 460 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 71712325 | 90940 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402895 | 90940 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 554 | 9 | 3 | 7 | 1.6 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]c(-c5ccccc5)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712463 | 90945 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402900 | 90945 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 465 | 9 | 3 | 6 | 1.4 | CC(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN(C)S(C)(=O)=O)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 11293856 | 84172 | 0 | None | 794 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 4.2 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179705 | 84172 | 0 | None | 794 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 4.2 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2221192 | 84172 | 0 | None | 794 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 4.2 | CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 53322004 | 56137 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 10 | 1 | 7 | 4.1 | CCOP(=O)(CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCC | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632164 | 56137 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 10 | 1 | 7 | 4.1 | CCOP(=O)(CCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1)OCC | 10.1016/j.bmc.2010.10.011 | ||
| 118712576 | 113726 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 8 | 2 | 6 | 4.2 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329810 | 113726 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 8 | 2 | 6 | 4.2 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1cccc2c1OCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| 118712578 | 113727 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 3.8 | O=C(OCC1CCN(CC2CCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329811 | 113727 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 3.8 | O=C(OCC1CCN(CC2CCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| 118712579 | 113728 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 454 | 6 | 1 | 6 | 4.2 | O=C(OCC1CCN(CC2CCCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329812 | 113728 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 454 | 6 | 1 | 6 | 4.2 | O=C(OCC1CCN(CC2CCCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| 44248186 | 193780 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL552484 | 193780 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 567 | 15 | 3 | 5 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 10524522 | 15335 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121776 | 15335 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnccn2)CC1 | 10.1021/jm0009538 | ||
| 10548505 | 112592 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccnn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL331396 | 112592 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccnn2)CC1 | 10.1021/jm0009538 | ||
| 133999 | 73951 | 6 | None | 5 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 318 | 3 | 1 | 4 | 2.2 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| CHEMBL202434 | 73951 | 6 | None | 5 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 318 | 3 | 1 | 4 | 2.2 | O=C(NC[C@@H]1CCN2CCC[C@@H]12)c1cc(Cl)cn2ccnc12 | 10.1021/jm0509501 | ||
| 52945318 | 17346 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 348 | 6 | 1 | 6 | 2.7 | CCCCN1CCC(COC(=O)c2ccc(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1257991 | 17346 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 348 | 6 | 1 | 6 | 2.7 | CCCCN1CCC(COC(=O)c2ccc(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 44592414 | 178581 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 332 | 3 | 2 | 3 | 2.8 | C[C@@]12CCCN1CC[C@H]2CNC(=O)c1cc(Cl)cc2nc[nH]c12 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL472219 | 178581 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 332 | 3 | 2 | 3 | 2.8 | C[C@@]12CCCN1CC[C@H]2CNC(=O)c1cc(Cl)cc2nc[nH]c12 | 10.1016/j.bmc.2008.11.045 | ||
| 9905514 | 119164 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(O)CC1 | 10.1021/jm960320m | ||
| CHEMBL347235 | 119164 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(O)CC1 | 10.1021/jm960320m | ||
| 10570203 | 49271 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 355 | 6 | 2 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(N)=O)CC1 | 10.1021/jm960320m | ||
| CHEMBL156554 | 49271 | 0 | None | - | 1 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 355 | 6 | 2 | 6 | 1.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(N)=O)CC1 | 10.1021/jm960320m | ||
| 10644148 | 113312 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL332553 | 113312 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccn2)CC1 | 10.1021/jm0009538 | ||
| 145980826 | 166087 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 326 | 6 | 0 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2ccnc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| CHEMBL4281416 | 166087 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 326 | 6 | 0 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2ccnc3ccccc23)CC1 | 10.1039/C8MD00233A | ||
| 11166796 | 82250 | 0 | None | 2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | 2 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 50898778 | 56146 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 427 | 9 | 2 | 5 | 3.5 | O=C(O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632174 | 56146 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 427 | 9 | 2 | 5 | 3.5 | O=C(O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 71712328 | 90943 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402898 | 90943 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 470 | 7 | 2 | 6 | 2.5 | COC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 177336 | 3059 | 45 | None | -6 | 3 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| 225 | 3059 | 45 | None | -6 | 3 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL356359 | 3059 | 45 | None | -6 | 3 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| DB04873 | 3059 | 45 | None | -6 | 3 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 10.1016/j.bmc.2013.09.004 | ||
| 118712577 | 113629 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 1 | 6 | 3.5 | O=C(OCC1CCN(CC2C3CC4C2C4C3C(=O)O)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329226 | 113629 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 1 | 6 | 3.5 | O=C(OCC1CCN(CC2C3CC4C2C4C3C(=O)O)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmcl.2014.06.083 | ||
| 70688535 | 76050 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059584 | 76050 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 586 | 13 | 2 | 7 | 4.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248184 | 194478 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL561278 | 194478 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 525 | 12 | 3 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 11166796 | 82250 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 10854687 | 48277 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)(C)C1 | 10.1021/jm960320m | ||
| CHEMBL155682 | 48277 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)(C)C1 | 10.1021/jm960320m | ||
| 42636941 | 178361 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 343 | 5 | 0 | 5 | 4.4 | CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL470432 | 178361 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 343 | 5 | 0 | 5 | 4.4 | CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 23202543 | 203674 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 493 | 11 | 2 | 6 | 3.7 | CS(=O)(=O)NCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OCc2ccccc2)CC1 | 10.1016/S0960-894X(01)80414-5 | ||
| CHEMBL80026 | 203674 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 493 | 11 | 2 | 6 | 3.7 | CS(=O)(=O)NCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OCc2ccccc2)CC1 | 10.1016/S0960-894X(01)80414-5 | ||
| 44323244 | 12264 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL1185621 | 12264 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL423504 | 12264 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| 22708808 | 205324 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91771 | 205324 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 365 | 6 | 2 | 4 | 3.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1 | 10.1016/0960-894X(96)00002-9 | ||
| 162662474 | 181462 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 494 | 10 | 3 | 7 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(N)cc2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4781228 | 181462 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 494 | 10 | 3 | 7 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(N)cc2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 71714544 | 90939 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402894 | 90939 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 542 | 9 | 3 | 7 | 1.1 | CC(F)(F)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44628200 | 82293 | 0 | None | 1584 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 456 | 7 | 1 | 5 | 5.0 | CC(=O)Nc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | ||
| CHEMBL2179670 | 82293 | 0 | None | 1584 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 456 | 7 | 1 | 5 | 5.0 | CC(=O)Nc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | ||
| 44628198 | 82297 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179674 | 82297 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccc(C(=O)O)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 44629279 | 82298 | 0 | None | 39 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.1 | Cn1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179678 | 82298 | 0 | None | 39 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 6 | 0 | 4 | 5.1 | Cn1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 53320713 | 56144 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 7 | 2 | 5 | 2.7 | O=C(O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632172 | 56144 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 399 | 7 | 2 | 5 | 2.7 | O=C(O)CCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 70682173 | 76043 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059577 | 76043 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 453 | 7 | 2 | 6 | 3.2 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCCCC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248189 91900499 | 193167 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL539713 | 193167 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 549 | 12 | 2 | 6 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248315 | 194237 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559322 | 194237 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 522 | 11 | 1 | 6 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 9819953 | 120784 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 4.5 | CCCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL35808 | 120784 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 4.5 | CCCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| 11520655 | 132297 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 792 | 19 | 4 | 12 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL370181 | 132297 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 792 | 19 | 4 | 12 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 17755141 | 78700 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113289 | 78700 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 17755141 | 78700 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| CHEMBL2113289 | 78700 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1183 | 28 | 4 | 16 | 9.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCN(CCCc2ccc(CCCN(CCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)C(=O)OC(C)(C)C)cc2)C(=O)OC(C)(C)C)CC1 | 10.1021/jm070552t | ||
| 44628201 | 82295 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179672 | 82295 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 11225102 | 76056 | 2 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059590 | 76056 | 2 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.05.034 | ||
| 11225102 | 76056 | 2 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2059590 | 76056 | 2 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 2.5 | CC(=O)N1CCN(CCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2nn(C(C)C)c4ccccc24)C3)CC1 | 10.1016/j.bmcl.2012.08.051 | ||
| 44248679 | 193916 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555693 | 193916 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 599 | 12 | 1 | 7 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248925 | 194736 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL562902 | 194736 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 436 | 9 | 2 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 10712297 | 186516 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC(C)C1 | 10.1021/jm960853v | ||
| CHEMBL49155 | 186516 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC(C)C1 | 10.1021/jm960853v | ||
| 10688750 | 206635 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 343 | 4 | 1 | 6 | 0.9 | CN1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL99590 | 206635 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 343 | 4 | 1 | 6 | 0.9 | CN1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 44281102 | 116202 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCC(OC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL33732 | 116202 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCC(OC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| 10584 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | ||
| 86582973 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL3417009 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | ||
| 10584 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.bmcl.2022.128873 | ||
| 86582973 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.bmcl.2022.128873 | ||
| CHEMBL3417009 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.bmcl.2022.128873 | ||
| 9881054 | 126518 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 4 | 1 | 4 | 4.1 | CCN1CCC(COc2nc3ccccc3c3c2CCCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL36558 | 126518 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 339 | 4 | 1 | 4 | 4.1 | CCN1CCC(COc2nc3ccccc3c3c2CCCCN3)CC1 | 10.1021/jm020954v | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 5 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm900018b | ||
| 5 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm901126m | ||
| 5202 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm900018b | ||
| 5202 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm901126m | ||
| CHEMBL39 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm900018b | ||
| CHEMBL39 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm901126m | ||
| DB08839 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm900018b | ||
| DB08839 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm901126m | ||
| 71457412 | 82547 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 348 | 5 | 0 | 3 | 5.2 | CCCN1CCC(COc2nc3c(C)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181186 | 82547 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 348 | 5 | 0 | 3 | 5.2 | CCCN1CCC(COc2nc3c(C)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 5311047 | 203045 | 30 | None | -5 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL74656 | 203045 | 30 | None | -5 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.05.034 | ||
| 70682705 | 77135 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087329 | 77135 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CNC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 70686942 | 77136 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087330 | 77136 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 483 | 7 | 3 | 6 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 5311047 | 203045 | 30 | None | -5 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL74656 | 203045 | 30 | None | -5 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1016/j.bmcl.2012.08.051 | ||
| 44248797 | 194029 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL557053 | 194029 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 353 | 7 | 2 | 4 | 3.3 | CCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 5 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | ||
| 5202 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | ||
| CHEMBL39 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | ||
| DB08839 | 139 | 66 | None | -190 | 55 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm990151g | ||
| 118712568 | 113718 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 516 | 9 | 3 | 4 | 4.8 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)Cc3ccccc3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329802 | 113718 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 516 | 9 | 3 | 4 | 4.8 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)Cc3ccccc3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | ||
| 44249189 91900488 | 193721 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL552075 | 193721 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 447 | 6 | 2 | 6 | 2.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248310 | 194871 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL563799 | 194871 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 512 | 6 | 1 | 6 | 3.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44575 | 195829 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL570074 | 195829 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 311 | 4 | 2 | 4 | 2.1 | CCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 15544715 | 112285 | 1 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 272 | 3 | 2 | 3 | 1.8 | CCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL330605 | 112285 | 1 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 272 | 3 | 2 | 3 | 1.8 | CCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 44327586 | 163268 | 1 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.2 | CCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL420638 | 163268 | 1 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.2 | CCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 15544721 | 98503 | 4 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 259 | 2 | 1 | 4 | 1.8 | CN1CCC(OC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL279823 | 98503 | 4 | None | - | 1 | Rat | 5.0 | pKi | = | 5 | Binding | ChEMBL | 259 | 2 | 1 | 4 | 1.8 | CN1CCC(OC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 155525723 | 170509 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4457426 | 170509 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 515 | 11 | 3 | 7 | 4.2 | COc1cc(/C=C/C(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)ccc1O | 10.1016/j.ejmech.2019.111596 | ||
| 71461048 | 82546 | 0 | None | -3 | 2 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3cc(F)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181185 | 82546 | 0 | None | -3 | 2 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3cc(F)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 10712151 | 119647 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 5 | 2 | 4 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CC(C)CC(C)C1 | 10.1021/jm960320m | ||
| CHEMBL351557 | 119647 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 339 | 5 | 2 | 4 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CC(C)CC(C)C1 | 10.1021/jm960320m | ||
| 10832327 | 4142 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 359 | 5 | 1 | 6 | 1.6 | CCN1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL100317 | 4142 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 359 | 5 | 1 | 6 | 1.6 | CCN1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 2780 | 110027 | 32 | None | -20 | 11 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/0960-894X(95)00115-A | ||
| CHEMBL325109 | 110027 | 32 | None | -20 | 11 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1016/0960-894X(95)00115-A | ||
| 2780 | 110027 | 32 | None | -20 | 11 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm020270n | ||
| CHEMBL325109 | 110027 | 32 | None | -20 | 11 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm020270n | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm801327q | ||
| 118734520 | 118159 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.4 | CO/N=C(\CCC1CCN(CC2CCCCC2)CC1)c1cc(Cl)c(N)cc1OC | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417005 | 118159 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.4 | CO/N=C(\CCC1CCN(CC2CCCCC2)CC1)c1cc(Cl)c(N)cc1OC | 10.1021/acs.jmedchem.5b00115 | ||
| 90644475 | 111777 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 3.4 | O=C1c2cccc3nc(Cl)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291080 | 111777 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 357 | 4 | 0 | 4 | 3.4 | O=C1c2cccc3nc(Cl)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| 136118638 | 75948 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058698 | 75948 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 10594888 | 4098 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.3 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2cc(F)ccc21 | 10.1021/jm981098j | ||
| CHEMBL100088 | 4098 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.3 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2cc(F)ccc21 | 10.1021/jm981098j | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 11686484 | 132308 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL370182 | 132308 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 11629240 | 140531 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL382543 | 140531 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 806 | 20 | 4 | 12 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 49783421 | 17591 | 0 | None | -51 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 9 | 1 | 5 | 3.3 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258786 | 17591 | 0 | None | -51 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 9 | 1 | 5 | 3.3 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCCF)c2)CC1 | 10.1021/jm100668r | ||
| 44592282 | 178617 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 355 | 6 | 0 | 5 | 4.5 | C=CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL472481 | 178617 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 355 | 6 | 0 | 5 | 4.5 | C=CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 15544716 | 110894 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL327192 | 110894 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 15544716 | 110894 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL327192 | 110894 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 15544716 | 110894 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL327192 | 110894 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 379 | 7 | 3 | 5 | 0.6 | CS(=O)(=O)NCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 10739944 | 78330 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL2112621 | 78330 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| 44592148 | 178267 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 329 | 5 | 0 | 5 | 4.1 | CCCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL469582 | 178267 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 329 | 5 | 0 | 5 | 4.1 | CCCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1021/jm020099f | ||
| 44582815 | 172647 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | ||
| CHEMBL452353 | 172647 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 621 | 11 | 3 | 9 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm801327q | ||
| 11557207 | 78630 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm050234z | ||
| CHEMBL2113160 | 78630 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1203 | 39 | 7 | 18 | 10.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNc2nc(NCCCCCCCCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)nc(NCc3ccccc3)n2)CC1 | 10.1021/jm050234z | ||
| 10925529 | 206151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL96667 | 206151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 132164 | 204912 | 8 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL89259 | 204912 | 8 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 10925529 | 206151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL96667 | 206151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 71457408 | 82534 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.7 | Ic1ccc(CCCN2CCC(COc3nc4ccccc4c4ccccc34)CC2)cc1 | 10.1021/jm300943r | ||
| CHEMBL2181167 | 82534 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 536 | 7 | 0 | 3 | 6.7 | Ic1ccc(CCCN2CCC(COc3nc4ccccc4c4ccccc34)CC2)cc1 | 10.1021/jm300943r | ||
| 10925529 | 206151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL96667 | 206151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 329 | 6 | 3 | 4 | 2.4 | CCCCN1CCC(CNC(=O)c2ccc(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 136118650 | 75955 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058705 | 75955 | 0 | None | -7 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 11039391 | 204551 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 617 | 11 | 2 | 9 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL86985 | 204551 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 617 | 11 | 2 | 9 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 42618251 | 186342 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 530 | 14 | 3 | 7 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccccc2)CC1 | 10.1021/jm801327q | ||
| CHEMBL490050 | 186342 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 530 | 14 | 3 | 7 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccccc2)CC1 | 10.1021/jm801327q | ||
| 49783418 | 17518 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 334 | 8 | 1 | 5 | 3.3 | CCCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258561 | 17518 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 334 | 8 | 1 | 5 | 3.3 | CCCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| 162652829 | 179796 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 4.5 | COc1ccc(S(=O)(=O)CCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4751840 | 179796 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 4.5 | COc1ccc(S(=O)(=O)CCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1016/j.ejmech.2016.05.048 | ||
| 162650788 | 179597 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 509 | 11 | 2 | 7 | 3.6 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4749344 | 179597 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 509 | 11 | 2 | 7 | 3.6 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1016/j.ejmech.2016.05.048 | ||
| 10270343 | 118521 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 4.9 | CCCCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL34263 | 118521 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 4.9 | CCCCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| 10408029 | 16268 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL123377 | 16268 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| 71714543 | 90938 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402893 | 90938 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 534 | 8 | 3 | 7 | 1.2 | CC(C)(C)c1nc2c(C(=O)NCC3CCN(CC(O)CN4CCN(S(C)(=O)=O)CC4)CC3)cccc2[nH]1 | 10.1016/j.bmcl.2013.05.018 | ||
| 11168006 | 76055 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059589 | 76055 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 502 | 7 | 1 | 7 | 1.9 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 44224237 | 193112 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL538635 | 193112 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 10291662 | 119685 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 353 | 5 | 1 | 4 | 4.5 | CCCN1CCC(COc2nc3ccccc3c3c2CCCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL35196 | 119685 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 353 | 5 | 1 | 4 | 4.5 | CCCN1CCC(COc2nc3ccccc3c3c2CCCCN3)CC1 | 10.1021/jm020954v | ||
| 155565664 | 175020 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4580044 | 175020 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 432 | 8 | 2 | 6 | 4.5 | COc1ccc(CN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1O | 10.1016/j.ejmech.2019.111596 | ||
| 44592186 | 178271 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 329 | 5 | 0 | 5 | 4.1 | Cc1csc2nc(OCCCN3CCCCC3)c3cccn3c12 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL469593 | 178271 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 329 | 5 | 0 | 5 | 4.1 | Cc1csc2nc(OCCCN3CCCCC3)c3cccn3c12 | 10.1016/j.bmc.2008.11.045 | ||
| 4595 | 176131 | 102 | None | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | 10.1021/jm00075a026 | ||
| CHEMBL46 | 176131 | 102 | None | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | 10.1021/jm00075a026 | ||
| 145957594 | 161417 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 791 | 33 | 3 | 15 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CC1 | 10.1039/C6MD00458J | ||
| CHEMBL4159138 | 161417 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 791 | 33 | 3 | 15 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CC1 | 10.1039/C6MD00458J | ||
| 118734521 | 118160 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 394 | 7 | 2 | 4 | 5.0 | COc1cc(N)c(Cl)cc1C(O)CCC1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417006 | 118160 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 394 | 7 | 2 | 4 | 5.0 | COc1cc(N)c(Cl)cc1C(O)CCC1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 10567201 | 183673 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 313 | 5 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC1 | 10.1021/jm960853v | ||
| CHEMBL48379 | 183673 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 313 | 5 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC1 | 10.1021/jm960853v | ||
| 260 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/s0960-894x(01)00693-x | ||
| 2775 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/s0960-894x(01)00693-x | ||
| 656665 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/s0960-894x(01)00693-x | ||
| CHEMBL56564 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/s0960-894x(01)00693-x | ||
| DB11699 | 3796 | 49 | None | -45 | 6 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/s0960-894x(01)00693-x | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.bmcl.2013.05.018 | ||
| 44629348 | 84146 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 4 | 6.1 | CC(C)n1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179677 | 84146 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 4 | 6.1 | CC(C)n1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2220955 | 84146 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 427 | 7 | 0 | 4 | 6.1 | CC(C)n1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 44249315 | 193495 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550459 | 193495 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 331 | 4 | 2 | 6 | 0.8 | CC(C)n1c(=O)n(C(=O)NCCN2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 44248066 | 193506 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL550530 | 193506 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 7 | 2 | 7 | 0.7 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 44249055 91900481 | 193738 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL552218 | 193738 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 4 | 1 | 4 | 3.3 | CCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 10643698 | 193771 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL552420 | 193771 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 383 | 5 | 2 | 5 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 3233 | 3443 | 40 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | ||
| 3247 | 3443 | 40 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | ||
| 6604889 | 3443 | 40 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | ||
| CHEMBL282199 | 3443 | 40 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | ||
| DB13988 | 3443 | 40 | None | -933 | 12 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 352 | 5 | 1 | 4 | 2.7 | CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O | 10.1021/jm991151j | ||
| 44249179 | 193145 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL539212 | 193145 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 312 | 5 | 3 | 5 | 0.6 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCNCC1 | 10.1021/jm900881j | ||
| 3157 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| 7170 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| 954 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| CHEMBL707 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| DB00590 | 1437 | 69 | None | -27 | 12 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | nan | ||
| 49845575 | 19148 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 467 | 5 | 0 | 5 | 4.9 | Cc1csc2nc(OCC3CCN(C/C=C/I)CC3)c3cccn3c12 | 10.1016/j.ejmech.2010.07.052 | ||
| CHEMBL1290805 | 19148 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 467 | 5 | 0 | 5 | 4.9 | Cc1csc2nc(OCC3CCN(C/C=C/I)CC3)c3cccn3c12 | 10.1016/j.ejmech.2010.07.052 | ||
| 11577105 | 71805 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 510 | 16 | 3 | 7 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN)CC1 | 10.1021/jm050234z | ||
| CHEMBL197965 | 71805 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 510 | 16 | 3 | 7 | 4.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN)CC1 | 10.1021/jm050234z | ||
| 11593090 | 71835 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 834 | 22 | 4 | 12 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198052 | 71835 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 834 | 22 | 4 | 12 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 44404964 | 72112 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198921 | 72112 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| 130946 | 201061 | 2 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/j.bmc.2008.12.025 | ||
| CHEMBL62023 | 201061 | 2 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1016/j.bmc.2008.12.025 | ||
| 145955141 | 162128 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 426 | 9 | 3 | 6 | 2.7 | CCCCNC(=O)NC1CCN(CCOC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1039/C6MD00458J | ||
| CHEMBL4170461 | 162128 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 426 | 9 | 3 | 6 | 2.7 | CCCCNC(=O)NC1CCN(CCOC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1039/C6MD00458J | ||
| 9858485 | 122602 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 325 | 4 | 1 | 4 | 3.7 | CCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL36120 | 122602 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 325 | 4 | 1 | 4 | 3.7 | CCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| 71462777 | 82538 | 0 | None | -1 | 4 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181171 | 82538 | 0 | None | -1 | 4 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 10045643 | 206334 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 385 | 7 | 1 | 6 | 2.1 | CCCCN1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL97755 | 206334 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 385 | 7 | 1 | 6 | 2.1 | CCCCN1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 71462776 | 82536 | 0 | None | -11 | 7 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 460 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181169 | 82536 | 0 | None | -11 | 7 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 460 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 9839847 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL98734 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 9839847 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| CHEMBL98734 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1039/C0MD00258E | ||
| 9839847 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL98734 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 9839847 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL98734 | 206495 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 6 | 2 | 3 | 2.8 | CCCCN1CCC(CNC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 6604914 | 99906 | 2 | None | 1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL28992 | 99906 | 2 | None | 1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00002-9 | ||
| 151537 | 162102 | 43 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | nan | ||
| 41867 | 162102 | 43 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | nan | ||
| CHEMBL417 | 162102 | 43 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | nan | ||
| 5991 | 202212 | 68 | None | 2 | 5 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 296 | 0 | 2 | 2 | 3.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C | nan | ||
| CHEMBL691 | 202212 | 68 | None | 2 | 5 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 296 | 0 | 2 | 2 | 3.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C | nan | ||
| 203435 | 163541 | 2 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1021/jm960320m | ||
| CHEMBL420969 | 163541 | 2 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 311 | 5 | 2 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)NCCN1CCCCC1 | 10.1021/jm960320m | ||
| 44404968 | 71995 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 711 | 20 | 3 | 8 | 6.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(Cc3ccccc3)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198504 | 71995 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 711 | 20 | 3 | 8 | 6.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(Cc3ccccc3)CC2)CC1 | 10.1021/jm050234z | ||
| 42618250 | 168883 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | ||
| CHEMBL442869 | 168883 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 982 | 28 | 6 | 14 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNCCCc2ccc(CCCNCCCC(=O)NC3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)cc2)CC1 | 10.1021/jm801327q | ||
| 72698085 | 103496 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 420 | 6 | 0 | 3 | 6.0 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1ccccc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL3093184 | 103496 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 420 | 6 | 0 | 3 | 6.0 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1ccccc12 | 10.1016/j.bmc.2013.08.061 | ||
| 10408029 | 16268 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL123377 | 16268 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| 118734516 | 118155 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 386 | 7 | 1 | 4 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417001 | 118155 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 386 | 7 | 1 | 4 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccccc2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm020270n | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm020270n | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm020270n | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm020270n | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm020270n | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm020270n | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm020270n | ||
| 10545215 | 188385 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | ||
| CHEMBL50852 | 188385 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.4 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1 | 10.1021/jm960853v | ||
| 118734508 | 117980 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3414597 | 117980 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 42646835 | 193474 | 2 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 261 | 4 | 2 | 4 | 1.5 | COc1ccc2[nH]cc(CNN3CCOCC3)c2c1 | 10.1016/j.ejmech.2009.01.015 | ||
| CHEMBL550302 | 193474 | 2 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 261 | 4 | 2 | 4 | 1.5 | COc1ccc2[nH]cc(CNN3CCOCC3)c2c1 | 10.1016/j.ejmech.2009.01.015 | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| 242 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | nan | ||
| 145991736 | 166280 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 355 | 7 | 1 | 4 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(OC)c3ccccc3n2)CC1 | 10.1039/C8MD00233A | ||
| CHEMBL4285302 | 166280 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 355 | 7 | 1 | 4 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(OC)c3ccccc3n2)CC1 | 10.1039/C8MD00233A | ||
| 145979545 | 166163 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 314 | 5 | 0 | 5 | 2.9 | COc1cc(C(=O)OCCN2CCCCC2)c2ccccc2n1 | 10.1039/C8MD00233A | ||
| CHEMBL4283020 | 166163 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 314 | 5 | 0 | 5 | 2.9 | COc1cc(C(=O)OCCN2CCCCC2)c2ccccc2n1 | 10.1039/C8MD00233A | ||
| 70695321 | 77132 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087326 | 77132 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 7 | 4 | 6 | 1.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNC(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 44247822 91900495 | 193833 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553685 | 193833 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 571 | 10 | 1 | 7 | 3.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248434 91900496 | 193956 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556326 | 193956 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 613 | 13 | 1 | 7 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248070 | 194141 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL558261 | 194141 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 557 | 13 | 2 | 7 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 44248552 91900486 | 194235 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559317 | 194235 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 4.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 10615288 | 186416 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | ||
| CHEMBL49072 | 186416 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 315 | 7 | 2 | 5 | 2.8 | CCN(CC)CCOC(=O)Nc1cc(Cl)c(N)cc1OC | 10.1021/jm960853v | ||
| 134828069 | 172720 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 410 | 7 | 1 | 3 | 5.7 | COc1c(C(=O)CCC2CCN(Cc3ccccc3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4526050 | 172720 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 410 | 7 | 1 | 3 | 5.7 | COc1c(C(=O)CCC2CCN(Cc3ccccc3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | ||
| 9819593 | 98335 | 2 | None | 1 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL27846 | 98335 | 2 | None | 1 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 71461046 | 82541 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3ccccc3c3ccc(F)cc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181175 | 82541 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3ccccc3c3ccc(F)cc23)CC1 | 10.1021/jm300943r | ||
| 10531 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 121 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 888 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| CHEMBL1732 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| DB00320 | 1387 | 18 | None | -87 | 24 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 108182 | 4055 | 18 | None | -1 | 17 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/0960-894X(96)00200-4 | ||
| 245 | 4055 | 18 | None | -1 | 17 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/0960-894X(96)00200-4 | ||
| CHEMBL18041 | 4055 | 18 | None | -1 | 17 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/0960-894X(96)00200-4 | ||
| 9906933 | 34228 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 360 | 3 | 1 | 4 | 3.6 | CC(C)n1cnc2c(C(=O)NC3CC4CCC(C3)N4C)cc(Cl)cc21 | 10.1016/0960-894X(96)00052-2 | ||
| CHEMBL142852 | 34228 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 360 | 3 | 1 | 4 | 3.6 | CC(C)n1cnc2c(C(=O)NC3CC4CCC(C3)N4C)cc(Cl)cc21 | 10.1016/0960-894X(96)00052-2 | ||
| 15231247 91900477 | 193969 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | ||
| CHEMBL556438 | 193969 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 309 | 3 | 3 | 4 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2 | 10.1021/jm900881j | ||
| 42499 | 193258 | 20 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL541969 | 193258 | 20 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 283 | 3 | 3 | 4 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCNCC1 | 10.1021/jm900881j | ||
| 44248794 | 193830 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553658 | 193830 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 2 | 2 | 5 | 1.7 | CC(C)n1c(=O)n(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 44247817 91900489 | 194291 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559746 | 194291 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 489 | 9 | 2 | 6 | 3.4 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 9935387 | 98970 | 0 | None | -1995 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | ||
| CHEMBL282971 | 98970 | 0 | None | -1995 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | ||
| 44247949 | 193434 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL549998 | 193434 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 475 | 12 | 3 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 11600413 | 67169 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 876 | 25 | 4 | 12 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCCCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL189580 | 67169 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 876 | 25 | 4 | 12 | 6.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCCCCCCCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 44404962 | 72185 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL199150 | 72185 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| 44592076 | 172145 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 317 | 8 | 0 | 5 | 4.1 | CCN(CC)CCCCOc1nc2ccsc2n2cccc12 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL450595 | 172145 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 317 | 8 | 0 | 5 | 4.1 | CCN(CC)CCCCOc1nc2ccsc2n2cccc12 | 10.1016/j.bmc.2008.11.045 | ||
| 44592108 | 178498 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 329 | 5 | 0 | 5 | 4.1 | CCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL471662 | 178498 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 329 | 5 | 0 | 5 | 4.1 | CCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 10292429 | 119684 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 367 | 6 | 1 | 4 | 4.9 | CCCCN1CCC(COc2nc3ccccc3c3c2CCCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL35195 | 119684 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 367 | 6 | 1 | 4 | 4.9 | CCCCN1CCC(COc2nc3ccccc3c3c2CCCCN3)CC1 | 10.1021/jm020954v | ||
| 162676850 | 182928 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 5.1 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2cc(Br)ccc2Br)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4799839 | 182928 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 5.1 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2cc(Br)ccc2Br)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 10645103 | 163778 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1021/jm0009538 | ||
| CHEMBL421256 | 163778 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1 | 10.1021/jm0009538 | ||
| 10546395 | 4126 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 6 | 1 | 6 | 1.4 | CCCN1CCN(CCNC(=O)n2c(=O)n(CC)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL100199 | 4126 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 6 | 1 | 6 | 1.4 | CCCN1CCN(CCNC(=O)n2c(=O)n(CC)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 10645984 | 18614 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL127876 | 18614 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1 | 10.1021/jm0009538 | ||
| 11841878 | 67240 | 5 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1016/0960-894X(96)00200-4 | ||
| CHEMBL19022 | 67240 | 5 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1016/0960-894X(96)00200-4 | ||
| 11841878 | 67240 | 5 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | ||
| CHEMBL19022 | 67240 | 5 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 332 | 2 | 2 | 3 | 3.0 | CN1C2CCCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | ||
| 10859701 | 67226 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | ||
| CHEMBL19006 | 67226 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | ||
| 10859701 | 67226 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| CHEMBL19006 | 67226 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(NC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| 11841879 | 120487 | 6 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(NC1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| CHEMBL356521 | 120487 | 6 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(NC1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| 9924349 | 175284 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 346 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4585990 | 175284 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 346 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| 9905225 | 205206 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91147 | 205206 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 321 | 2 | 2 | 4 | 1.7 | Nc1c(Cl)cc(C(=O)N[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0509501 | ||
| 49783417 | 17517 | 0 | None | -18 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 306 | 6 | 1 | 5 | 2.6 | CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258560 | 17517 | 0 | None | -18 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 306 | 6 | 1 | 5 | 2.6 | CCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| 49783420 | 17553 | 0 | None | -51 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 338 | 8 | 1 | 5 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258672 | 17553 | 0 | None | -51 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 338 | 8 | 1 | 5 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(N)c(OCF)c2)CC1 | 10.1021/jm100668r | ||
| 71461049 | 82548 | 0 | None | 1 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181187 | 82548 | 0 | None | 1 | 6 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 10669778 | 116959 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1021/jm0009538 | ||
| CHEMBL339936 | 116959 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1021/jm0009538 | ||
| 11791805 | 107041 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 345 | 5 | 1 | 6 | 1.0 | CCN1CCN(CCNC(=O)n2c(=O)n(CC)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL318764 | 107041 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 345 | 5 | 1 | 6 | 1.0 | CCN1CCN(CCNC(=O)n2c(=O)n(CC)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 10267187 | 204762 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL88310 | 204762 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | ||
| 10331436 | 321 | 7 | None | -8511 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | ||
| 160 | 321 | 7 | None | -8511 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | ||
| CHEMBL133455 | 321 | 7 | None | -8511 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N | 10.1021/jm030205t | ||
| 11146446 | 105461 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 603 | 10 | 2 | 9 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL312940 | 105461 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 603 | 10 | 2 | 9 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 90666003 | 108786 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 378 | 5 | 0 | 6 | 4.2 | c1cc2c(OCC3CCN(Cc4ccncc4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| CHEMBL3218875 | 108786 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 378 | 5 | 0 | 6 | 4.2 | c1cc2c(OCC3CCN(Cc4ccncc4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| 176155 | 4086 | 0 | None | -1 | 4 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 377 | 4 | 1 | 3 | 4.7 | C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 | nan | ||
| CHEMBL10 | 4086 | 0 | None | -1 | 4 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 377 | 4 | 1 | 3 | 4.7 | C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 | nan | ||
| 11714901 | 133796 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL371718 | 133796 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 904 | 27 | 4 | 12 | 7.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNC(=O)CCCCCCCCCCC(=O)NCCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 162673811 | 182557 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 493 | 10 | 2 | 6 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4795251 | 182557 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 493 | 10 | 2 | 6 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 44592111 | 189206 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 329 | 4 | 0 | 5 | 4.0 | CC(C)N1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL516340 | 189206 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 329 | 4 | 0 | 5 | 4.0 | CC(C)N1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 162667581 | 181893 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 539 | 12 | 2 | 8 | 3.6 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)c(OC)c1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4786794 | 181893 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 539 | 12 | 2 | 8 | 3.6 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)c(OC)c1 | 10.1016/j.ejmech.2016.05.048 | ||
| 10919426 | 204488 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 659 | 14 | 2 | 9 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL86624 | 204488 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 659 | 14 | 2 | 9 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 9856041 | 23895 | 2 | None | -5888 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 | 10.1021/jm030205t | ||
| CHEMBL133868 | 23895 | 2 | None | -5888 | 9 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 230 | 2 | 2 | 2 | 2.4 | CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3 | 10.1021/jm030205t | ||
| 11813759 | 204563 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 564 | 8 | 1 | 8 | 4.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | ||
| CHEMBL87063 | 204563 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 564 | 8 | 1 | 8 | 4.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | ||
| 2585 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| 522 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| 551 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| CHEMBL723 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| DB01136 | 788 | 100 | None | -57 | 22 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | nan | ||
| 11050452 | 48867 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 631 | 12 | 2 | 9 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL156206 | 48867 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 631 | 12 | 2 | 9 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm960320m | ||
| 10615623 | 156569 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 319 | 2 | 3 | 4 | 1.6 | Nc1c(Cl)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | ||
| CHEMBL407493 | 156569 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 319 | 2 | 3 | 4 | 1.6 | Nc1c(Cl)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | ||
| 11527897 | 133763 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 780 | 18 | 4 | 13 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL371707 | 133763 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 780 | 18 | 4 | 13 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 182593 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1039/C8MD00233A | ||
| 254 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1039/C8MD00233A | ||
| CHEMBL83954 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1039/C8MD00233A | ||
| 182593 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | ||
| 254 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL83954 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.ejmech.2014.05.015 | ||
| 182593 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1039/C6MD00458J | ||
| 254 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1039/C6MD00458J | ||
| CHEMBL83954 | 3331 | 4 | None | -1 | 3 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1039/C6MD00458J | ||
| 9861687 | 188600 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 315 | 4 | 0 | 5 | 3.7 | CCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL511312 | 188600 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 315 | 4 | 0 | 5 | 3.7 | CCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 67251061 | 82294 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 443 | 8 | 0 | 5 | 5.2 | COCc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | ||
| CHEMBL2179671 | 82294 | 0 | None | 10 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 443 | 8 | 0 | 5 | 5.2 | COCc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1 | 10.1021/jm300573d | ||
| 11842633 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 8425 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087337 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 10.1016/j.bmcl.2012.08.051 | ||
| 67276168 | 77140 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087334 | 77140 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 490 | 8 | 3 | 7 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CNS(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 11432106 | 77141 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087335 | 77141 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 11519716 | 193814 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553405 | 193814 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247941 | 194105 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL557867 | 194105 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 498 | 9 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 71461047 | 82544 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3cc(OC)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181183 | 82544 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3cc(OC)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 10028436 | 3463 | 3 | None | -954 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | ||
| 3237 | 3463 | 3 | None | -954 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | ||
| CHEMBL95104 | 3463 | 3 | None | -954 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 487 | 7 | 1 | 4 | 4.9 | Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2 | 10.1016/s0960-894x(02)00690-x | ||
| 11177588 | 94732 | 3 | None | -5 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 418 | 5 | 6 | 3 | 1.1 | N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)NC1=O | 10.1021/np0601760 | ||
| CHEMBL255898 | 94732 | 3 | None | -5 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 418 | 5 | 6 | 3 | 1.1 | N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)NC1=O | 10.1021/np0601760 | ||
| 118734519 | 118158 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 407 | 7 | 2 | 5 | 5.2 | COc1cc(N)c(Cl)cc1/C(CCC1CCN(CC2CCCCC2)CC1)=N/O | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417004 | 118158 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 407 | 7 | 2 | 5 | 5.2 | COc1cc(N)c(Cl)cc1/C(CCC1CCN(CC2CCCCC2)CC1)=N/O | 10.1021/acs.jmedchem.5b00115 | ||
| 2274 | 3112 | 53 | None | -17 | 32 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 4917 | 3112 | 53 | None | -17 | 32 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 7279 | 3112 | 53 | None | -17 | 32 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| CHEMBL728 | 3112 | 53 | None | -17 | 32 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| DB00433 | 3112 | 53 | None | -17 | 32 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | nan | ||
| 10623729 | 112574 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL331264 | 112574 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1021/jm0009538 | ||
| 260 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| 2775 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| 656665 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL56564 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| DB11699 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/j.bmc.2008.11.045 | ||
| 44628269 | 82296 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccccc4C(=O)O)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179673 | 82296 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.8 | Cn1cc2c(OCC3CCN(CCc4ccccc4C(=O)O)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 44248317 | 194215 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL559050 | 194215 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 559 | 12 | 1 | 7 | 2.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 20030109 | 194667 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL562477 | 194667 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 327 | 5 | 3 | 5 | 1.1 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCO)CC1 | 10.1021/jm900881j | ||
| 15295138 | 50774 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| CHEMBL157880 | 50774 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| 10741078 | 112329 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)nn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL330848 | 112329 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)nn2)CC1 | 10.1021/jm0009538 | ||
| 42618252 | 186088 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | ||
| CHEMBL488325 | 186088 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 580 | 13 | 3 | 8 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCNS(=O)(=O)c2ccc(C)cc2)CC1 | 10.1021/jm801327q | ||
| 49783209 | 17412 | 0 | None | -3 | 27 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258223 | 17412 | 0 | None | -3 | 27 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 53321958 | 56145 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 413 | 8 | 2 | 5 | 3.1 | O=C(O)CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632173 | 56145 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 413 | 8 | 2 | 5 | 3.1 | O=C(O)CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 49783419 | 17552 | 0 | None | -6 | 13 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258671 | 17552 | 0 | None | -6 | 13 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 2.8 | CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 5324247 | 206305 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL97594 | 206305 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 5324247 | 206305 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1021/jm020807x | ||
| CHEMBL97594 | 206305 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1021/jm020807x | ||
| 71455625 | 82537 | 0 | None | -54 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| 71455625 | 82537 | 0 | None | -54 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181170 | 82537 | 0 | None | -54 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL2181170 | 82537 | 0 | None | -54 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 353 | 5 | 0 | 4 | 4.4 | CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 257 | 3424 | 9 | None | -1 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 5311423 | 3424 | 9 | None | -1 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| CHEMBL114112 | 3424 | 9 | None | -1 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 10.1021/jm100668r | ||
| 5324247 | 206305 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL97594 | 206305 | 1 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 3.3 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3C)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 118734522 | 118161 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 6 | 2 | 4 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417007 | 118161 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 6 | 2 | 4 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 15544728 | 205809 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94784 | 205809 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 15544728 | 205809 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL94784 | 205809 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 15544728 | 205809 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94784 | 205809 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 1.6 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 249 | 2518 | 3 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 9905972 | 2518 | 3 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| CHEMBL155917 | 2518 | 3 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10.1021/jm960320m | ||
| 10522209 | 101213 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 355 | 5 | 2 | 5 | 3.5 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CC(C)CC(C)C1 | 10.1021/jm960853v | ||
| CHEMBL299408 | 101213 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 355 | 5 | 2 | 5 | 3.5 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CC(C)CC(C)C1 | 10.1021/jm960853v | ||
| 49783415 | 17481 | 0 | None | -3 | 13 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258452 | 17481 | 0 | None | -3 | 13 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| 53318013 | 56147 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 511 | 15 | 2 | 5 | 5.9 | O=C(O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632175 | 56147 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 511 | 15 | 2 | 5 | 5.9 | O=C(O)CCCCCCCCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 118734513 | 120112 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCNCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3416998 | 120112 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCNCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3546835 | 120112 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCNCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 71459269 | 82533 | 0 | None | -10 | 8 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 555 | 7 | 0 | 4 | 6.3 | Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 | 10.1021/jm300943r | ||
| CHEMBL2181166 | 82533 | 0 | None | -10 | 8 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 555 | 7 | 0 | 4 | 6.3 | Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12 | 10.1021/jm300943r | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10.1016/j.bmc.2008.11.045 | ||
| 44629350 | 84145 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 3.2 | Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179676 | 84145 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 3.2 | Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2220954 | 84145 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 408 | 6 | 0 | 6 | 3.2 | Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 67472601 | 92429 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 7 | 1 | 8 | 5.3 | O=C(OCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440456 | 92429 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 7 | 1 | 8 | 5.3 | O=C(OCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| 70686434 | 76049 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059583 | 76049 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 560 | 10 | 3 | 8 | 2.0 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCC(CNS(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 70684288 | 76052 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059586 | 76052 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 558 | 11 | 1 | 7 | 3.5 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 11504722 | 76054 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059588 | 76054 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248922 | 193221 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL540981 | 193221 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 627 | 14 | 2 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248921 | 193566 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551013 | 193566 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 520 | 11 | 1 | 5 | 5.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 41585 | 101137 | 3 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | CCOc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL298920 | 101137 | 3 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | CCOc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| 10566592 | 185295 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 306 | 5 | 1 | 4 | 3.2 | COc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| CHEMBL48684 | 185295 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 306 | 5 | 1 | 4 | 3.2 | COc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1 | 10.1021/jm960853v | ||
| 71451950 | 82249 | 5 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 53324017 | 56142 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 371 | 5 | 2 | 5 | 2.0 | O=C(O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632170 | 56142 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 371 | 5 | 2 | 5 | 2.0 | O=C(O)CN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1 | 10.1016/j.bmc.2010.10.011 | ||
| 15544727 | 106745 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL316856 | 106745 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 9881053 | 119727 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.1 | CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL35226 | 119727 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.1 | CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| 15544727 | 106745 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL316856 | 106745 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 15544727 | 106745 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL316856 | 106745 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 349 | 6 | 1 | 4 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 11622025 | 143202 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL390075 | 143202 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 848 | 23 | 4 | 12 | 6.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2014.05.015 | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2014.05.015 | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2014.05.015 | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2014.05.015 | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2014.05.015 | ||
| 5311047 | 203045 | 30 | None | 5 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1039/C6MD00458J | ||
| CHEMBL74656 | 203045 | 30 | None | 5 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC | 10.1039/C6MD00458J | ||
| 71461050 | 82550 | 0 | None | -6 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| 71461050 | 82550 | 0 | None | -6 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181189 | 82550 | 0 | None | -6 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL2181189 | 82550 | 0 | None | -6 | 5 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 118734517 | 118156 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2cccnc2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417002 | 118156 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2cccnc2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 118734518 | 118157 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccncc2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417003 | 118157 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 387 | 7 | 1 | 5 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccncc2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 44592183 | 178251 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 343 | 6 | 0 | 5 | 4.4 | CCCCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL469379 | 178251 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 343 | 6 | 0 | 5 | 4.4 | CCCCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 44592109 | 178499 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 343 | 6 | 0 | 5 | 4.4 | CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL471663 | 178499 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 343 | 6 | 0 | 5 | 4.4 | CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 11686510 | 71955 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 820 | 21 | 2 | 12 | 5.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198372 | 71955 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 820 | 21 | 2 | 12 | 5.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 1235483 | 37752 | 1 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| CHEMBL146012 | 37752 | 1 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 304 | 2 | 2 | 3 | 2.0 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| 31703 | 193040 | 59 | None | 1 | 3 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | ||
| CHEMBL359744 | 193040 | 59 | None | 1 | 3 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | ||
| CHEMBL53463 | 193040 | 59 | None | 1 | 3 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | nan | ||
| 71452074 | 82540 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3ccccc3c3cc(F)ccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181173 | 82540 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3ccccc3c3cc(F)ccc23)CC1 | 10.1021/jm300943r | ||
| 11650641 | 71730 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL197751 | 71730 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 132337 | 3474 | 8 | None | -1 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020270n | ||
| 238 | 3474 | 8 | None | -1 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020270n | ||
| CHEMBL34291 | 3474 | 8 | None | -1 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm020270n | ||
| 90666008 | 108791 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 0 | 5 | 5.1 | Cc1csc2nc(OCC3CCN(CC4CCCC4)CC3)c3cccn3c12 | 10.1039/C2MD20063E | ||
| CHEMBL3218880 | 108791 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 5 | 0 | 5 | 5.1 | Cc1csc2nc(OCC3CCN(CC4CCCC4)CC3)c3cccn3c12 | 10.1039/C2MD20063E | ||
| 71462781 | 82551 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3ccccc3c3cccc(F)c23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181190 | 82551 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3ccccc3c3cccc(F)c23)CC1 | 10.1021/jm300943r | ||
| 71450247 | 82549 | 0 | None | -4 | 9 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181188 | 82549 | 0 | None | -4 | 9 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 90666002 | 108785 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 407 | 6 | 0 | 6 | 4.8 | COc1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| CHEMBL3218874 | 108785 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 407 | 6 | 0 | 6 | 4.8 | COc1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| 10760942 | 106794 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 359 | 4 | 1 | 6 | 1.5 | Cc1cccc2c1n(C(C)C)c(=O)n2C(=O)NCCN1CCN(C)CC1 | 10.1021/jm981098j | ||
| CHEMBL317146 | 106794 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 359 | 4 | 1 | 6 | 1.5 | Cc1cccc2c1n(C(C)C)c(=O)n2C(=O)NCCN1CCN(C)CC1 | 10.1021/jm981098j | ||
| 44592283 | 188668 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 391 | 5 | 0 | 5 | 5.1 | Cc1csc2nc(OCC3CCN(Cc4ccccc4)CC3)c3cccn3c12 | 10.1039/C2MD20063E | ||
| CHEMBL511837 | 188668 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 391 | 5 | 0 | 5 | 5.1 | Cc1csc2nc(OCC3CCN(Cc4ccccc4)CC3)c3cccn3c12 | 10.1039/C2MD20063E | ||
| 72697940 | 103500 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 406 | 5 | 0 | 3 | 5.6 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1ccccc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL3093194 | 103500 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 406 | 5 | 0 | 3 | 5.6 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1ccccc12 | 10.1016/j.bmc.2013.08.061 | ||
| 11810608 | 206304 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL97591 | 206304 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 11810608 | 206304 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL97591 | 206304 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 11810608 | 206304 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL97591 | 206304 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 363 | 6 | 3 | 4 | 3.0 | CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 162670887 | 182377 | 0 | None | 7 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 543 | 11 | 2 | 7 | 4.2 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1Cl | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4793078 | 182377 | 0 | None | 7 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 543 | 11 | 2 | 7 | 4.2 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1Cl | 10.1016/j.ejmech.2016.05.048 | ||
| 71452073 | 82539 | 0 | None | 17 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3cnccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181172 | 82539 | 0 | None | 17 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3cnccc23)CC1 | 10.1021/jm300943r | ||
| 136118637 | 75947 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2c(Br)cccc12 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058697 | 75947 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2c(Br)cccc12 | 10.1016/j.bmc.2013.09.011 | ||
| 3397 | 203767 | 104 | None | 1 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 276 | 3 | 1 | 3 | 3.2 | CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 | nan | ||
| CHEMBL806 | 203767 | 104 | None | 1 | 2 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 276 | 3 | 1 | 3 | 3.2 | CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 | nan | ||
| 136118649 | 75954 | 0 | None | -2 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058704 | 75954 | 0 | None | -2 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 10618741 | 165116 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 363 | 2 | 3 | 4 | 1.7 | Nc1c(Br)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | ||
| CHEMBL424498 | 165116 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 363 | 2 | 3 | 4 | 1.7 | Nc1c(Br)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | ||
| 44281492 | 118354 | 2 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL34224 | 118354 | 2 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 298 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OC1CCN(C)CC1 | 10.1016/S0960-894X(01)80508-4 | ||
| 10408029 | 16268 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL123377 | 16268 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| 10834000 | 16138 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 385 | 6 | 1 | 7 | 1.9 | CCOC(=O)N1CCN(CCOC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm0009538 | ||
| CHEMBL122818 | 16138 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 385 | 6 | 1 | 7 | 1.9 | CCOC(=O)N1CCN(CCOC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm0009538 | ||
| 10669143 | 113742 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL333028 | 113742 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 1 | 6 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(F)cc2)CC1 | 10.1021/jm0009538 | ||
| 6604794 | 37409 | 7 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 346 | 3 | 1 | 4 | 3.1 | CC(C)n1cnc2c(C(=O)N[C@H]3CN4CCC3CC4)cc(Cl)cc21 | 10.1016/0960-894X(96)00052-2 | ||
| CHEMBL145725 | 37409 | 7 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 346 | 3 | 1 | 4 | 3.1 | CC(C)n1cnc2c(C(=O)N[C@H]3CN4CCC3CC4)cc(Cl)cc21 | 10.1016/0960-894X(96)00052-2 | ||
| 5 | 139 | 66 | None | -190 | 55 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | ||
| 5202 | 139 | 66 | None | -190 | 55 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | ||
| CHEMBL39 | 139 | 66 | None | -190 | 55 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | ||
| DB08839 | 139 | 66 | None | -190 | 55 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00014a021 | ||
| 10069545 | 56267 | 0 | None | -831 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2Cc1ccccc1 | 10.1016/0960-894X(95)00115-A | ||
| CHEMBL164169 | 56267 | 0 | None | -831 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2Cc1ccccc1 | 10.1016/0960-894X(95)00115-A | ||
| 71462780 | 82543 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3ccc(OC)cc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181181 | 82543 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3ccc(OC)cc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 10069545 | 56267 | 0 | None | -831 | 3 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2Cc1ccccc1 | 10.1021/jm020270n | ||
| CHEMBL164169 | 56267 | 0 | None | -831 | 3 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 5 | 2 | 4 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2Cc1ccccc1 | 10.1021/jm020270n | ||
| 136118646 | 75951 | 0 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058701 | 75951 | 0 | None | -2 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 136118635 | 75944 | 0 | None | -6 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058694 | 75944 | 0 | None | -6 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 321 | 1 | 3 | 2 | 2.3 | O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12 | 10.1016/j.bmc.2013.09.011 | ||
| 11549456 | 78627 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL2113157 | 78627 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 11146533 | 106555 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 616 | 13 | 2 | 8 | 5.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL315590 | 106555 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 616 | 13 | 2 | 8 | 5.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 162668604 | 181994 | 0 | None | 6 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 587 | 11 | 2 | 7 | 4.4 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1Br | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4788022 | 181994 | 0 | None | 6 | 2 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 587 | 11 | 2 | 7 | 4.4 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1Br | 10.1016/j.ejmech.2016.05.048 | ||
| 15544722 | 205804 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94756 | 205804 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 15544722 | 205804 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL94756 | 205804 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 15544722 | 205804 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94756 | 205804 | 1 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 1 | 4 | 3.2 | CCCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 10811181 | 162931 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL420166 | 162931 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(Cc2ccccc2)CC1 | 10.1021/jm0009538 | ||
| 44299805 | 100602 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC1CN2C | 10.1016/s0960-894x(01)00693-x | ||
| CHEMBL294894 | 100602 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC1CN2C | 10.1016/s0960-894x(01)00693-x | ||
| 9947817 | 4963 | 0 | None | -436 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| CHEMBL105261 | 4963 | 0 | None | -436 | 9 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2019.111596 | ||
| 71459270 | 82542 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 348 | 5 | 0 | 3 | 5.2 | CCCN1CCC(COc2nc3ccc(C)cc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181180 | 82542 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 348 | 5 | 0 | 3 | 5.2 | CCCN1CCC(COc2nc3ccc(C)cc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 441383 | 20118 | 54 | None | -5 | 17 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | ||
| CHEMBL1306 | 20118 | 54 | None | -5 | 17 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | nan | ||
| 155559813 | 174257 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 338 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(CC2CCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4562793 | 174257 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 338 | 6 | 1 | 2 | 5.0 | O=C(CCC1CCN(CC2CCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| 10569278 | 186657 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | ||
| CHEMBL49266 | 186657 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 341 | 5 | 2 | 5 | 3.2 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1 | 10.1021/jm960853v | ||
| 70695322 | 77134 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087328 | 77134 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 469 | 7 | 4 | 6 | 1.6 | CNC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 10737191 | 206568 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 5 | 1 | 6 | 1.4 | CCn1c(=O)n(C(=O)NCCN2CCN(C(C)C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL99147 | 206568 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 5 | 1 | 6 | 1.4 | CCn1c(=O)n(C(=O)NCCN2CCN(C(C)C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| 44592110 | 188568 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 357 | 7 | 0 | 5 | 4.8 | CCCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL511148 | 188568 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 357 | 7 | 0 | 5 | 4.8 | CCCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 90666005 | 108788 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 355 | 5 | 0 | 5 | 4.4 | c1cc2c(OCC3CCN(CC4CCC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| CHEMBL3218877 | 108788 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 355 | 5 | 0 | 5 | 4.4 | c1cc2c(OCC3CCN(CC4CCC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| 6604789 | 100565 | 3 | None | 12 | 10 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | ||
| CHEMBL294649 | 100565 | 3 | None | 12 | 10 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | ||
| 71712613 | 90934 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402889 | 90934 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 464 | 7 | 3 | 7 | -0.3 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(NC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44248793 91900478 | 193940 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556235 | 193940 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 3 | 2 | 4 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249053 | 194816 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL563445 | 194816 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 6 | 2 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 6918647 | 100265 | 2 | None | -501 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | ||
| CHEMBL292759 | 100265 | 2 | None | -501 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | ||
| 44247945 | 194386 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL560597 | 194386 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 391 | 6 | 3 | 6 | 1.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 10831381 | 206289 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 345 | 5 | 1 | 6 | 1.0 | CCCn1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL97508 | 206289 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 345 | 5 | 1 | 6 | 1.0 | CCCn1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| 131725 | 198743 | 2 | None | -3 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm960320m | ||
| CHEMBL59834 | 198743 | 2 | None | -3 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm960320m | ||
| 162649188 | 179507 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 523 | 12 | 2 | 7 | 4.0 | COc1ccc(S(=O)(=O)NCCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4748287 | 179507 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 523 | 12 | 2 | 7 | 4.0 | COc1ccc(S(=O)(=O)NCCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1 | 10.1016/j.ejmech.2016.05.048 | ||
| 15544723 | 205693 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL94099 | 205693 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 15544723 | 205693 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94099 | 205693 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 15544723 | 205693 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94099 | 205693 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 2 | 6 | 1.0 | CS(=O)(=O)NCCN1CCC(COC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 10741712 | 206566 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 439 | 6 | 1 | 6 | 2.9 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(Cc3ccc(F)cc3)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL99141 | 206566 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 439 | 6 | 1 | 6 | 2.9 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(Cc3ccc(F)cc3)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| 10897011 | 167591 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 560 | 9 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL433149 | 167591 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 560 | 9 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 1043 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 149 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 8223 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| CHEMBL442 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| DB00696 | 1545 | 13 | None | -2884 | 29 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | nan | ||
| 11825705 | 107709 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL319663 | 107709 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 11825705 | 107709 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL319663 | 107709 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 11825705 | 107709 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL319663 | 107709 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2cc(Br)c(N)c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 850953 | 38160 | 2 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| CHEMBL146368 | 38160 | 2 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| 133 | 2450 | 48 | None | -79 | 43 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 1723 | 2450 | 48 | None | -79 | 43 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 28693 | 2450 | 48 | None | -79 | 43 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| CHEMBL19215 | 2450 | 48 | None | -79 | 43 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| DB13520 | 2450 | 48 | None | -79 | 43 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | nan | ||
| 182593 | 3331 | 4 | None | -2 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 254 | 3331 | 4 | None | -2 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| CHEMBL83954 | 3331 | 4 | None | -2 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1021/jm960320m | ||
| 10425296 | 162835 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL419496 | 162835 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 306 | 2 | 1 | 3 | 2.1 | O=C(N[C@H]1CN2CCC1CC2)c1cc(Cl)cc2c1OCC2 | 10.1016/0960-894X(96)00002-9 | ||
| 9819593 | 98335 | 2 | None | -1 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00052-2 | ||
| CHEMBL27846 | 98335 | 2 | None | -1 | 2 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00052-2 | ||
| 90644472 | 111774 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.1 | COc1cc2c3c(cccc3n1)CN(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291077 | 111774 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 339 | 5 | 0 | 4 | 3.1 | COc1cc2c3c(cccc3n1)CN(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| 44327605 | 205748 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94415 | 205748 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/jm0205651 | ||
| 9906777 | 92799 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1021/jm0509501 | ||
| CHEMBL2448165 | 92799 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 321 | 3 | 2 | 4 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(C2)CC31 | 10.1021/jm0509501 | ||
| 44592185 | 188797 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 5 | 0 | 5 | 3.8 | C=CCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL513020 | 188797 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 5 | 0 | 5 | 3.8 | C=CCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.ejmech.2009.01.015 | ||
| 11724799 | 10417 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1016/0960-894X(95)00115-A | ||
| CHEMBL116913 | 10417 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 339 | 0 | 2 | 5 | 1.5 | Nc1cc2c(cc1Cl)C(=O)NC1CCN(CCOCCO2)CC1 | 10.1016/0960-894X(95)00115-A | ||
| 44327605 | 205748 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL94415 | 205748 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 44327605 | 205748 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL94415 | 205748 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 2.6 | CCCCN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 10550242 | 17060 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/jm0009538 | ||
| CHEMBL125670 | 17060 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1 | 10.1021/jm0009538 | ||
| 11629268 | 71918 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 824 | 21 | 4 | 14 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198271 | 71918 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 824 | 21 | 4 | 14 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCOCCOCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 11796362 | 114590 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1021/jm0009538 | ||
| CHEMBL334325 | 114590 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | 10.1021/jm0009538 | ||
| 118734510 | 118150 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 7 | 1 | 4 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3416996 | 118150 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 7 | 1 | 4 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 71461050 | 82550 | 0 | None | 6 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL2181189 | 82550 | 0 | None | 6 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| 71461050 | 82550 | 0 | None | 6 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181189 | 82550 | 0 | None | 6 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 44247820 91900493 | 193121 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL538706 | 193121 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 12 | 1 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248435 | 193897 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555210 | 193897 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 623 | 15 | 2 | 5 | 7.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247953 | 194135 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558163 | 194135 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 581 | 12 | 2 | 5 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249183 | 194696 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL562636 | 194696 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 478 | 12 | 2 | 5 | 5.0 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2CCCCC2)CC1 | 10.1021/jm900881j | ||
| 162669699 | 182129 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 607 | 12 | 2 | 9 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(OC)c(N3CCN(C)CC3)c2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4789661 | 182129 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 607 | 12 | 2 | 9 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(OC)c(N3CCN(C)CC3)c2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 10715463 | 16160 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccncc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL122914 | 16160 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 1 | 7 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccncc2)CC1 | 10.1021/jm0009538 | ||
| 71462652 | 82257 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| CHEMBL2179590 | 82257 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 8 | 2 | 8 | 2.6 | CC(C)(O)COc1cccc2onc(OCC3CCN(CC4(O)CCOCC4)CC3)c12 | 10.1021/jm300953p | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 183782 | 3334 | 15 | None | 1 | 15 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| 237 | 3334 | 15 | None | 1 | 15 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| CHEMBL85251 | 3334 | 15 | None | 1 | 15 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1039/C8MD00233A | ||
| 5145950 | 201785 | 4 | None | -5 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1021/jm400766k | ||
| CHEMBL586946 | 201785 | 4 | None | -5 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1021/jm400766k | ||
| CHEMBL66114 | 201785 | 4 | None | -5 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 553 | 13 | 2 | 8 | 3.7 | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1 | 10.1021/jm400766k | ||
| 118734511 | 118151 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 406 | 7 | 1 | 4 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3416997 | 118151 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 406 | 7 | 1 | 4 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 71451950 | 82249 | 5 | None | 1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | 1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 19081885 | 203623 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 4.0 | CCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1039/C6MD00458J | ||
| CHEMBL79637 | 203623 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 4.0 | CCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1039/C6MD00458J | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmc.2008.11.045 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmc.2008.11.045 | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2013.05.018 | ||
| 71712464 | 90946 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402901 | 90946 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 445 | 8 | 3 | 6 | 2.2 | COC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 71712465 | 90947 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402902 | 90947 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 8 | 3 | 5 | 2.0 | CC(=O)N(C)CC(O)CN1CCC(CNC(=O)c2cccc3[nH]c(C(C)C)nc23)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 72697299 | 92428 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 547 | 7 | 2 | 7 | 4.9 | O=C(NCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440455 | 92428 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 547 | 7 | 2 | 7 | 4.9 | O=C(NCC1CCN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)CC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.05.034 | ||
| 70688534 | 76045 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059579 | 76045 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 441 | 8 | 2 | 6 | 3.0 | CC(C)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 11677434 | 76047 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059581 | 76047 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 483 | 9 | 2 | 7 | 2.8 | COC[C@@H]1CCCN1CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1nn(C(C)C)c3ccccc13)C2 | 10.1016/j.bmcl.2012.05.034 | ||
| 11606227 | 76051 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059585 | 76051 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1016/j.bmcl.2012.08.051 | ||
| 44248437 | 193158 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL539651 | 193158 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 597 | 12 | 1 | 6 | 6.1 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 10971995 | 161845 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 427 | 6 | 2 | 7 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)OC(C)(C)C)CC1 | 10.1039/C6MD00458J | ||
| CHEMBL4165966 | 161845 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 427 | 6 | 2 | 7 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)OC(C)(C)C)CC1 | 10.1039/C6MD00458J | ||
| 145978961 | 165988 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 429 | 6 | 1 | 7 | 3.4 | COc1cc(C(=O)OCCN2CCC(NC(=O)OC(C)(C)C)CC2)c2ccccc2n1 | 10.1039/C8MD00233A | ||
| CHEMBL4279553 | 165988 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 429 | 6 | 1 | 7 | 3.4 | COc1cc(C(=O)OCCN2CCC(NC(=O)OC(C)(C)C)CC2)c2ccccc2n1 | 10.1039/C8MD00233A | ||
| 10543526 | 206631 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 317 | 3 | 1 | 6 | 0.1 | CN1CCN(CCNC(=O)n2c(=O)n(C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL99578 | 206631 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 317 | 3 | 1 | 6 | 0.1 | CN1CCN(CCNC(=O)n2c(=O)n(C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 11714709 | 78628 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 750 | 16 | 4 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL2113158 | 78628 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 750 | 16 | 4 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 11039730 | 204515 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 687 | 16 | 2 | 9 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL86777 | 204515 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 687 | 16 | 2 | 9 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1021/np0601760 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1021/np0601760 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1021/np0601760 | ||
| 182593 | 3331 | 4 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.bmc.2008.11.045 | ||
| 254 | 3331 | 4 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL83954 | 3331 | 4 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10.1016/j.bmc.2008.11.045 | ||
| 71459132 | 84130 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.4 | CC(C)n1nc(C(=O)NCC2CC[N+](C)(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2179698 | 84130 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.4 | CC(C)n1nc(C(=O)NCC2CC[N+](C)(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| CHEMBL2220893 | 84130 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 7 | 1 | 3 | 4.4 | CC(C)n1nc(C(=O)NCC2CC[N+](C)(CCc3ccccc3)CC2)c2ccccc21 | 10.1021/jm300573d | ||
| 67276466 | 77130 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087324 | 77130 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 3 | 6 | 1.8 | CC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 44248311 91900487 | 193947 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL556279 | 193947 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 596 | 12 | 1 | 6 | 5.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCN2C(=O)c3ccccc3C2=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 39736 | 183640 | 8 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 4 | 1 | 3 | 2.7 | O=C(Nc1ccccc1)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL48351 | 183640 | 8 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 248 | 4 | 1 | 3 | 2.7 | O=C(Nc1ccccc1)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| 71712612 | 90933 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402888 | 90933 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 0.2 | CS(=O)(=O)N1CCN(CC(O)CN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cccc4[nH]cnc24)C3)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 9817713 | 193159 | 53 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | ||
| CHEMBL539652 | 193159 | 53 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 297 | 4 | 3 | 4 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1 | 10.1021/jm900881j | ||
| 44249316 91900479 | 193672 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551820 | 193672 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 328 | 2 | 2 | 5 | 2.2 | CC(C)n1c(=O)n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| 44248796 | 193834 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 302 | 5 | 3 | 4 | 0.8 | COc1ccc2[nH]cc(C(=O)NCCN3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| CHEMBL553688 | 193834 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 302 | 5 | 3 | 4 | 0.8 | COc1ccc2[nH]cc(C(=O)NCCN3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| 10346043 | 46841 | 0 | None | -3162 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 503 | 5 | 2 | 5 | 3.4 | COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | ||
| CHEMBL154274 | 46841 | 0 | None | -3162 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 503 | 5 | 2 | 5 | 3.4 | COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | ||
| 6918648 | 101076 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | ||
| CHEMBL29846 | 101076 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | ||
| 44249311 | 193646 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551614 | 193646 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.1 | CC(C)n1c(=O)c(C(=O)NC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249317 91900480 | 193661 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | ||
| CHEMBL551743 | 193661 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 299 | 3 | 3 | 3 | 2.2 | COc1ccc2[nH]cc(C(=O)N[C@@H]3C[C@@H]4CC[C@H](C3)N4)c2c1 | 10.1021/jm900881j | ||
| 44249318 | 194185 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 273 | 3 | 3 | 3 | 1.7 | COc1ccc2[nH]cc(C(=O)NC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| CHEMBL558757 | 194185 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 273 | 3 | 3 | 3 | 1.7 | COc1ccc2[nH]cc(C(=O)NC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| 6918648 | 101076 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | ||
| CHEMBL29846 | 101076 | 1 | None | -5128 | 14 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | ||
| 11841877 | 39593 | 1 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 318 | 2 | 2 | 3 | 2.6 | CN1C2CCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | ||
| CHEMBL147725 | 39593 | 1 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 318 | 2 | 2 | 3 | 2.6 | CN1C2CCC1CC(NC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | ||
| 11093246 | 111044 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 602 | 12 | 2 | 8 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL327999 | 111044 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 602 | 12 | 2 | 8 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 10408029 | 16268 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL123377 | 16268 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| 49783206 | 17380 | 0 | None | -74 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 373 | 6 | 1 | 7 | 2.6 | CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258108 | 17380 | 0 | None | -74 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 373 | 6 | 1 | 7 | 2.6 | CCCCN1CCC(COC(=O)c2cc(C#N)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 71461048 | 82546 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3cc(F)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181185 | 82546 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 352 | 5 | 0 | 3 | 5.0 | CCCN1CCC(COc2nc3cc(F)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 10667079 | 205605 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 373 | 7 | 1 | 6 | 1.8 | CCCCN1CCN(CCNC(=O)n2c(=O)n(CC)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL93611 | 205605 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 373 | 7 | 1 | 6 | 1.8 | CCCCN1CCN(CCNC(=O)n2c(=O)n(CC)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 44281491 | 111969 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCCC(OC(=O)c2cc(Cl)c(N)cc2OC)C1 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL32986 | 111969 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 2.6 | CCN1CCCC(OC(=O)c2cc(Cl)c(N)cc2OC)C1 | 10.1016/S0960-894X(01)80508-4 | ||
| 90644478 | 111778 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 5 | 0 | 5 | 3.7 | O=C1c2cccc3nc(N4CCCCC4)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291083 | 111778 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 5 | 0 | 5 | 3.7 | O=C1c2cccc3nc(N4CCCCC4)cc(c23)C(=O)N1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| 71461049 | 82548 | 0 | None | -2 | 6 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181187 | 82548 | 0 | None | -2 | 6 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 10018558 | 50464 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 314 | 5 | 1 | 6 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCOCC1 | 10.1021/jm960320m | ||
| CHEMBL157631 | 50464 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 314 | 5 | 1 | 6 | 1.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCOCC1 | 10.1021/jm960320m | ||
| 44364334 | 39701 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 319 | 2 | 1 | 4 | 3.0 | CN1C2CCC1CC(OC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | ||
| CHEMBL147827 | 39701 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 319 | 2 | 1 | 4 | 3.0 | CN1C2CCC1CC(OC(=O)c1cc(Cl)cc3[nH]cnc13)C2 | 10.1021/jm991076c | ||
| 54677674 | 112298 | 4 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291085 | 112298 | 4 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3306918 | 112298 | 4 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 2 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)NCCCN2CCCCC2)c(O)c2ccsc21 | 10.1016/j.ejmech.2014.05.015 | ||
| 11498641 | 78629 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL2113159 | 78629 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 736 | 15 | 4 | 12 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 49783212 | 17479 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258450 | 17479 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 7 | 1 | 7 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C#N)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 44592145 | 188774 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 6 | 0 | 5 | 4.2 | C=CCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL512841 | 188774 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 6 | 0 | 5 | 4.2 | C=CCCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/0960-894X(96)00002-9 | ||
| 155517675 | 169611 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 6 | 1 | 2 | 6.1 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1cc(Cl)c2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4444843 | 169611 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 386 | 6 | 1 | 2 | 6.1 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1cc(Cl)c2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| 155545651 | 172882 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 5.4 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4529710 | 172882 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 5.4 | O=C(CCC1CCN(CC2CCCCC2)CC1)c1ccc2[nH]ccc2c1 | 10.1016/j.ejmech.2018.10.064 | ||
| 2353 | 100630 | 75 | None | -1 | 5 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.1 | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 | nan | ||
| CHEMBL12089 | 100630 | 75 | None | -1 | 5 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.1 | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 | nan | ||
| CHEMBL295124 | 100630 | 75 | None | -1 | 5 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 336 | 2 | 0 | 4 | 3.1 | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 | nan | ||
| 146025727 | 171109 | 0 | None | -138 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| CHEMBL4466483 | 171109 | 0 | None | -138 | 27 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| 10552840 | 163718 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 483 | 9 | 1 | 7 | 3.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(CCCOc3ccc(F)cc3)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL421187 | 163718 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 483 | 9 | 1 | 7 | 3.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(CCCOc3ccc(F)cc3)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| 136118639 | 75949 | 0 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058699 | 75949 | 0 | None | -2 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 44592146 | 187773 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 301 | 3 | 0 | 5 | 3.3 | CN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL501309 | 187773 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 301 | 3 | 0 | 5 | 3.3 | CN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 850954 | 40001 | 2 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| CHEMBL148080 | 40001 | 2 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 348 | 2 | 2 | 3 | 2.1 | O=C(N[C@@H]1CN2CCC1CC2)c1cc(Br)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| 10643950 | 107935 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 7 | 1 | 6 | 2.4 | CCCCN1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL319886 | 107935 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 387 | 7 | 1 | 6 | 2.4 | CCCCN1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 44352308 | 116971 | 0 | None | -46 | 12 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | ||
| CHEMBL339980 | 116971 | 0 | None | -46 | 12 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | ||
| 6604914 | 99906 | 2 | None | 1 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(95)00115-A | ||
| CHEMBL28992 | 99906 | 2 | None | 1 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(95)00115-A | ||
| 6604914 | 99906 | 2 | None | 1 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL28992 | 99906 | 2 | None | 1 | 2 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 6604914 | 99906 | 2 | None | -1 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm020270n | ||
| CHEMBL28992 | 99906 | 2 | None | -1 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1021/jm020270n | ||
| 10568248 | 185386 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 5 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL48698 | 185386 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 5 | 2 | 5 | 3.0 | COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| 145988372 | 166726 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 359 | 6 | 1 | 3 | 4.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c3ccccc3n2)CC1 | 10.1039/C8MD00233A | ||
| CHEMBL4293603 | 166726 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 359 | 6 | 1 | 3 | 4.1 | CCCCN1CCC(CNC(=O)c2cc(Cl)c3ccccc3n2)CC1 | 10.1039/C8MD00233A | ||
| 10545158 | 50070 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C(C)CCCC1C | 10.1021/jm960320m | ||
| CHEMBL157233 | 50070 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 340 | 5 | 1 | 5 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C(C)CCCC1C | 10.1021/jm960320m | ||
| 10666045 | 206653 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 357 | 5 | 1 | 6 | 1.3 | CN1CCN(CCCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL99723 | 206653 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 357 | 5 | 1 | 6 | 1.3 | CN1CCN(CCCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 67276147 | 77131 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087325 | 77131 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 7 | 2 | 6 | 2.1 | CC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 70684790 | 77139 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087333 | 77139 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 484 | 7 | 2 | 7 | 2.4 | COC(=O)N(C)CC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 44248191 | 193220 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| CHEMBL540980 | 193220 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 8 | 1 | 7 | 3.5 | CCOC(=O)N1CCN(CCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| 44247951 91900497 | 193233 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL541223 | 193233 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 539 | 9 | 2 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(C)CCc2c[nH]c3ccccc23)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248076 | 193364 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL549449 | 193364 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 543 | 8 | 1 | 7 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248195 | 193402 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL549650 | 193402 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 7 | 1 | 6 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCOCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248072 | 193992 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| CHEMBL556595 | 193992 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 483 | 9 | 3 | 5 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN(C)CCc2c[nH]c3ccccc23)CC1 | 10.1021/jm900881j | ||
| 44248068 | 194202 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| CHEMBL558924 | 194202 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 515 | 10 | 2 | 7 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN2CCN(S(C)(=O)=O)CC2)CC1 | 10.1021/jm900881j | ||
| 44247943 | 194264 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL559548 | 194264 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 540 | 12 | 2 | 6 | 4.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 44249188 | 194428 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL560940 | 194428 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 316 | 3 | 2 | 5 | 1.9 | CC(C)n1c(=O)n(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 10337773 | 101101 | 0 | None | 31 | 10 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | ||
| CHEMBL298612 | 101101 | 0 | None | 31 | 10 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 1.6 | Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21 | 10.1016/0960-894X(95)00308-G | ||
| 67211178 | 82300 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 3 | 1 | 4 | 3.1 | Cn1cc2c(OCC3CCNCC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179680 | 82300 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 295 | 3 | 1 | 4 | 3.1 | Cn1cc2c(OCC3CCNCC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 10493462 | 200791 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL61130 | 200791 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 286 | 3 | 2 | 4 | 2.1 | CC(C)n1nc(C(=O)NC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 10413595 | 161280 | 0 | None | -12589 | 11 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | ||
| CHEMBL414628 | 161280 | 0 | None | -12589 | 11 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.5 | COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1 | 10.1016/s0960-894x(00)00597-7 | ||
| 276 | 3444 | 45 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | ||
| 5312149 | 3444 | 45 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | ||
| CHEMBL431298 | 3444 | 45 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1021/jm980532e | ||
| 44248795 | 195944 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| CHEMBL570780 | 195944 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 287 | 4 | 3 | 3 | 1.9 | COc1ccc2[nH]cc(C(=O)NCC3CCNCC3)c2c1 | 10.1021/jm900881j | ||
| 276 | 3444 | 45 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | ||
| 5312149 | 3444 | 45 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | ||
| CHEMBL431298 | 3444 | 45 | None | -2691 | 13 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 4.1 | COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl | 10.1016/s0960-894x(02)00172-5 | ||
| 145957993 | 161619 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 692 | 19 | 5 | 11 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCNC(=O)NCC(=O)OCc2ccccc2)CC1 | 10.1039/C6MD00458J | ||
| CHEMBL4162531 | 161619 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 692 | 19 | 5 | 11 | 1.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCNC(=O)NCC(=O)OCc2ccccc2)CC1 | 10.1039/C6MD00458J | ||
| 145951595 | 162235 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 854 | 21 | 6 | 14 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCNC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1039/C6MD00458J | ||
| CHEMBL4172346 | 162235 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 854 | 21 | 6 | 14 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCNC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1039/C6MD00458J | ||
| 9973684 | 51184 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C)CC1 | 10.1021/jm960320m | ||
| CHEMBL158238 | 51184 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C)CC1 | 10.1021/jm960320m | ||
| 10519226 | 101504 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 4 | 3.4 | COc1ccc(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL301510 | 101504 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 312 | 5 | 1 | 4 | 3.4 | COc1ccc(Cl)cc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| 90666009 | 108792 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 5 | 0 | 5 | 5.5 | Cc1csc2nc(OCC3CCN(CC4CCCCC4)CC3)c3cccn3c12 | 10.1039/C2MD20063E | ||
| CHEMBL3218881 | 108792 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 5 | 0 | 5 | 5.5 | Cc1csc2nc(OCC3CCN(CC4CCCCC4)CC3)c3cccn3c12 | 10.1039/C2MD20063E | ||
| 72698088 | 103499 | 0 | None | -20 | 5 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 5.4 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL3093187 | 103499 | 0 | None | -20 | 5 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 421 | 6 | 0 | 4 | 5.4 | Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| 11166796 | 82250 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | -2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 44213661 | 205338 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL91842 | 205338 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 2.9 | Nc1c(Cl)cc(C(=O)OCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 53357016 | 82248 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | ||
| CHEMBL2179581 | 82248 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 446 | 7 | 1 | 8 | 3.0 | OC1(CN2CCC(COc3noc4cccc(OC5CCOCC5)c34)CC2)CCOCC1 | 10.1021/jm300953p | ||
| 49783210 | 17442 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258338 | 17442 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 440 | 7 | 1 | 6 | 3.9 | CCCCN1CCC(COC(=O)c2cc(Br)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL4172315 | 211470 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)NCCCN(CCCCN(CCCNC(=O)NCc3cn(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)nn3)CCCNC(=O)NCc3cn(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)nn3)CCCNC(=O)NCc3cn(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)nn3)nn2)CC1 | 10.1039/C6MD00458J | ||||
| 71457409 | 82535 | 0 | None | -17 | 6 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181168 | 82535 | 0 | None | -17 | 6 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 5 | 0 | 4 | 4.9 | CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 71451950 | 82249 | 5 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 15295138 | 50774 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| CHEMBL157880 | 50774 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 328 | 5 | 2 | 6 | 1.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1 | 10.1021/jm960320m | ||
| 118734515 | 118154 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 406 | 7 | 1 | 4 | 5.4 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCC2C)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417000 | 118154 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 406 | 7 | 1 | 4 | 5.4 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCCCC2C)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 11166796 | 82250 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 44374544 | 52858 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1021/jm020270n | ||
| CHEMBL159825 | 52858 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN2CCC1C2 | 10.1021/jm020270n | ||
| 134828071 | 173179 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.1 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4537101 | 173179 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.1 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)cc(Cl)c2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | ||
| 10020895 | 4622 | 0 | None | -524 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL103479 | 4622 | 0 | None | -524 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | ||
| 71452073 | 82539 | 0 | None | -17 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3cnccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181172 | 82539 | 0 | None | -17 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3cnccc23)CC1 | 10.1021/jm300943r | ||
| 44213663 | 204845 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL88867 | 204845 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | Nc1c(Cl)cc(C(=O)NCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 44592003 | 188875 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 301 | 4 | 0 | 5 | 3.4 | c1cc2c(OCCN3CCCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL513740 | 188875 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 301 | 4 | 0 | 5 | 3.4 | c1cc2c(OCCN3CCCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| 44323269 | 11952 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL1183709 | 11952 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL314198 | 11952 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 378 | 5 | 2 | 3 | 3.0 | CCCC[N+]12CCC(CC1)[C@@H](NC(=O)c1cc(Cl)c(N)c3c1OCC3)C2 | 10.1016/0960-894X(96)00002-9 | ||
| 6604914 | 99906 | 2 | None | -1 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00052-2 | ||
| CHEMBL28992 | 99906 | 2 | None | -1 | 2 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 | 10.1016/0960-894X(96)00052-2 | ||
| 90644473 | 111775 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 2.7 | COc1cc2c3c(cccc3n1)C(=O)N(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291078 | 111775 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 2.7 | COc1cc2c3c(cccc3n1)C(=O)N(CCCN1CCCCC1)C2=O | 10.1016/j.ejmech.2014.05.015 | ||
| 135446149 | 206434 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL98397 | 206434 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 135446149 | 206434 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL98397 | 206434 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 135446149 | 206434 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL98397 | 206434 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2cc(Cl)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 90666006 | 108789 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 369 | 5 | 0 | 5 | 4.8 | c1cc2c(OCC3CCN(CC4CCCC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| CHEMBL3218878 | 108789 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 369 | 5 | 0 | 5 | 4.8 | c1cc2c(OCC3CCN(CC4CCCC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| 10566528 | 161579 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | ||
| CHEMBL416172 | 161579 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1016/0960-894X(96)00200-4 | ||
| 10566528 | 161579 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| CHEMBL416172 | 161579 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 305 | 2 | 1 | 4 | 2.5 | O=C(OC1CN2CCC1CC2)c1cc(Cl)cc2nc[nH]c12 | 10.1021/jm991076c | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | nan | ||
| 41581 | 189221 | 4 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1cccc(NC(=O)OCCN2CCCCC2)c1 | 10.1021/jm960853v | ||
| CHEMBL51647 | 189221 | 4 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1cccc(NC(=O)OCCN2CCCCC2)c1 | 10.1021/jm960853v | ||
| 44404969 | 71903 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 930 | 18 | 4 | 13 | 6.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCc2ccc3c(c2)oc2cc(CCC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)ccc23)CC1 | 10.1021/jm050234z | ||
| CHEMBL198226 | 71903 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 930 | 18 | 4 | 13 | 6.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCc2ccc3c(c2)oc2cc(CCC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)ccc23)CC1 | 10.1021/jm050234z | ||
| 10802184 | 53858 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | ||
| CHEMBL160705 | 53858 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 272 | 5 | 1 | 5 | 1.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C | 10.1021/jm960320m | ||
| 135442121 | 111868 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL329545 | 111868 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 136118648 | 75953 | 0 | None | -9 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058703 | 75953 | 0 | None | -9 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 9797313 | 101446 | 1 | None | -154 | 3 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1016/0960-894X(95)00115-A | ||
| CHEMBL301039 | 101446 | 1 | None | -154 | 3 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1016/0960-894X(95)00115-A | ||
| 9797313 | 101446 | 1 | None | -151 | 3 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020270n | ||
| CHEMBL301039 | 101446 | 1 | None | -151 | 3 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm020270n | ||
| 135442121 | 111868 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL329545 | 111868 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 135442121 | 111868 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL329545 | 111868 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 7 | 2 | 5 | 3.5 | CCCCN1CCC(CNC(=O)c2cc(Br)c([N+](=O)[O-])c3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 9797313 | 101446 | 1 | None | -154 | 3 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm960320m | ||
| CHEMBL301039 | 101446 | 1 | None | -154 | 3 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 323 | 3 | 2 | 4 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C | 10.1021/jm960320m | ||
| 44592184 | 178270 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 357 | 7 | 0 | 5 | 4.8 | CCCCCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL469592 | 178270 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 357 | 7 | 0 | 5 | 4.8 | CCCCCN1CCC(COc2nc3sccc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 10757374 | 162530 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL41769 | 162530 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| 11520559 | 71954 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 750 | 16 | 2 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198371 | 71954 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 750 | 16 | 2 | 12 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCC(=O)N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 10757374 | 162530 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL41769 | 162530 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 9956365 | 193836 | 0 | None | -131 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 470 | 7 | 2 | 4 | 4.1 | CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 | 10.1021/jm0104264 | ||
| CHEMBL553794 | 193836 | 0 | None | -131 | 3 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 470 | 7 | 2 | 4 | 4.1 | CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2 | 10.1021/jm0104264 | ||
| 10687803 | 206606 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 329 | 3 | 1 | 6 | 0.9 | CN1CCN(CNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL99452 | 206606 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 329 | 3 | 1 | 6 | 0.9 | CN1CCN(CNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 155544687 | 174449 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 7 | 1 | 2 | 4.6 | CCCCN1CCC(CCC(=O)c2ccc3[nH]ccc3c2)CC1 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4567394 | 174449 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 7 | 1 | 2 | 4.6 | CCCCN1CCC(CCC(=O)c2ccc3[nH]ccc3c2)CC1 | 10.1016/j.ejmech.2018.10.064 | ||
| 90665997 | 108782 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 4.9 | c1ccc(CCN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| CHEMBL3218869 | 108782 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 4.9 | c1ccc(CCN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm050234z | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm050234z | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm050234z | ||
| 44404965 | 71726 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL197745 | 71726 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| 44404960 | 71732 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL197752 | 71732 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 736 | 15 | 5 | 12 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| 11629247 | 72034 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 812 | 16 | 4 | 12 | 4.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCc2cccc(CNC(=O)C3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)c2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198668 | 72034 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 812 | 16 | 4 | 12 | 4.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCc2cccc(CNC(=O)C3CCN(CCOC(=O)c4cc(Cl)c(N)cc4OC)CC3)c2)CC1 | 10.1021/jm050234z | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm801327q | ||
| 42618248 | 186435 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | ||
| CHEMBL490852 | 186435 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 479 | 8 | 2 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)Cc2ccccc2Cl)CC1 | 10.1021/jm801327q | ||
| 71450247 | 82549 | 0 | None | 4 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181188 | 82549 | 0 | None | 4 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 368 | 5 | 0 | 3 | 5.5 | CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 71712329 | 90944 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402899 | 90944 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 454 | 7 | 2 | 5 | 2.3 | CC(=O)N1CCN(CCN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44628133 | 84144 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2179675 | 84144 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| CHEMBL2220953 | 84144 | 0 | None | 50 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.6 | Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1 | 10.1021/jm300573d | ||
| 53320666 | 56148 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 447 | 6 | 2 | 5 | 3.8 | O=C(O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | ||
| CHEMBL1632176 | 56148 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 447 | 6 | 2 | 5 | 3.8 | O=C(O)c1ccc(CN2CCC(CNC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2010.10.011 | ||
| 44248319 | 193813 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL553404 | 193813 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 615 | 16 | 1 | 7 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCN(C)CCCN(C)S(C)(=O)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248680 | 193899 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555223 | 193899 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 3.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC(CNS(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248313 91900492 | 194181 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558719 | 194181 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 9 | 1 | 5 | 5.0 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 132337 | 3474 | 8 | None | -1 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| 238 | 3474 | 8 | None | -1 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| CHEMBL34291 | 3474 | 8 | None | -1 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 10.1021/jm0509501 | ||
| 71460941 | 82255 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | ||
| CHEMBL2179588 | 82255 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 5.1 | CCCCN1CCC(COc2noc3cccc(OCC(C)(C)C)c23)CC1 | 10.1021/jm300953p | ||
| 258 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| 5191 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL287045 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| 162663493 | 181410 | 0 | None | 30 | 4 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 572 | 10 | 3 | 7 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(N)c(Br)c2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4780536 | 181410 | 0 | None | 30 | 4 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 572 | 10 | 3 | 7 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(N)c(Br)c2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 10447437 | 49781 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | ||
| CHEMBL156970 | 49781 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 5 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1 | 10.1021/jm960320m | ||
| 44592233 | 188760 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 357 | 6 | 0 | 5 | 4.7 | CCCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL512679 | 188760 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 357 | 6 | 0 | 5 | 4.7 | CCCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 10498232 | 51076 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1 | 10.1021/jm960320m | ||
| CHEMBL158147 | 51076 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 5 | 1 | 5 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1 | 10.1021/jm960320m | ||
| 258 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960853v | ||
| 5191 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960853v | ||
| CHEMBL287045 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960853v | ||
| 258 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| 5191 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| CHEMBL287045 | 3498 | 25 | None | -2 | 8 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm960320m | ||
| 11166796 | 82250 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179583 | 82250 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 5 | 2 | 7 | 2.3 | CC(C)n1c(=O)n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm070552t | ||
| 155543353 | 172719 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| CHEMBL4526049 | 172719 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 3 | 6 | 4.2 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | 10.1016/j.ejmech.2019.111596 | ||
| 11643822 | 157305 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL408379 | 157305 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1158 | 38 | 6 | 15 | 8.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCCCCCCN(CCCCCCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC(=O)NCC2CCNCC2)CC1 | 10.1021/jm050234z | ||
| 162652332 | 179758 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 550 | 10 | 2 | 8 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc3c(c2)N(C)CCO3)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4751353 | 179758 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 550 | 10 | 2 | 8 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc3c(c2)N(C)CCO3)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 49783414 | 17480 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258451 | 17480 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 320 | 7 | 1 | 5 | 2.9 | CCCCN1CCC(COC(=O)c2ccc(N)cc2OC)CC1 | 10.1021/jm100668r | ||
| 70691118 | 77133 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087327 | 77133 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 469 | 7 | 3 | 6 | 1.7 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(N)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 70686943 | 77137 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087331 | 77137 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 2 | 6 | 2.3 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CC(O)CN(C)C(=O)N(C)C)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 70684789 | 77138 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 470 | 7 | 3 | 7 | 2.0 | COC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087332 | 77138 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 470 | 7 | 3 | 7 | 2.0 | COC(=O)NCC(O)CN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1016/j.bmcl.2012.08.051 | ||
| 70695323 | 77142 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| CHEMBL2087336 | 77142 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 8 | 2 | 7 | 1.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN(C)S(C)(=O)=O)cc2ccccc21 | 10.1016/j.bmcl.2012.08.051 | ||
| 44248923 | 193257 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL541968 | 193257 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 559 | 8 | 2 | 8 | 1.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248080 91900498 | 194193 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558855 | 194193 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 2.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCC[C@@H]2C(N)=O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44249057 91900485 | 194415 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL560876 | 194415 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 467 | 11 | 2 | 5 | 4.6 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/np0601760 | ||
| 118712567 | 113717 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 508 | 8 | 3 | 4 | 4.9 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | ||
| CHEMBL3329801 | 113717 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 508 | 8 | 3 | 4 | 4.9 | O=C(NCC1CCN(Cc2ccc(NS(=O)(=O)C3CCCCC3)cc2)CC1)c1c[nH]c2ccccc12 | 10.1016/j.bmcl.2014.06.083 | ||
| 189 | 3423 | 31 | None | -2089 | 18 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | 10.1021/jm00014a004 | ||
| 5163 | 3423 | 31 | None | -2089 | 18 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | 10.1021/jm00014a004 | ||
| CHEMBL297784 | 3423 | 31 | None | -2089 | 18 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | 10.1021/jm00014a004 | ||
| 9913554 | 100510 | 0 | None | -6309 | 14 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | ||
| CHEMBL29433 | 100510 | 0 | None | -6309 | 14 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | ||
| 9928343 | 102982 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| CHEMBL3085015 | 102982 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 349 | 4 | 2 | 4 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| 155523661 | 170327 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 382 | 7 | 1 | 3 | 5.4 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)ccc2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL4454706 | 170327 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 382 | 7 | 1 | 3 | 5.4 | COc1c(C(=O)CCC2CCN(CC3CCCCC3)CC2)ccc2[nH]ccc12 | 10.1016/j.ejmech.2018.10.064 | ||
| 71453895 | 82063 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 4.9 | CCCN1CCC(COc2nc3ccccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| 71453895 | 82063 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 4.9 | CCCN1CCC(COc2nc3ccccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2177145 | 82063 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 4.9 | CCCN1CCC(COc2nc3ccccc3c3ccccc23)CC1 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL2177145 | 82063 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 334 | 5 | 0 | 3 | 4.9 | CCCN1CCC(COc2nc3ccccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 135453290 | 133070 | 23 | None | -169 | 8 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 191 | 2 | 2 | 4 | 1.1 | C[C@H](N)Cn1ncc2ccc(O)cc21 | 10.1021/jm050663x | ||
| CHEMBL371300 | 133070 | 23 | None | -169 | 8 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 191 | 2 | 2 | 4 | 1.1 | C[C@H](N)Cn1ncc2ccc(O)cc21 | 10.1021/jm050663x | ||
| 90644470 | 111773 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 3.3 | COc1cc(C(=O)OCCCN2CCCCC2)c2ccccc2n1 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291075 | 111773 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 328 | 6 | 0 | 5 | 3.3 | COc1cc(C(=O)OCCCN2CCCCC2)c2ccccc2n1 | 10.1016/j.ejmech.2014.05.015 | ||
| 44592041 | 178440 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 315 | 5 | 0 | 5 | 3.8 | c1cc2c(OCCCN3CCCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL471234 | 178440 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 315 | 5 | 0 | 5 | 3.8 | c1cc2c(OCCCN3CCCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| 44592284 | 178439 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.8 | c1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| CHEMBL471231 | 178439 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.8 | c1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| 90666004 | 108787 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 341 | 5 | 0 | 5 | 4.1 | c1cc2c(OCC3CCN(CC4CC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| CHEMBL3218876 | 108787 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 341 | 5 | 0 | 5 | 4.1 | c1cc2c(OCC3CCN(CC4CC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| 15544720 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL18769 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 136118640 | 75950 | 0 | None | -4 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058700 | 75950 | 0 | None | -4 | 3 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 335 | 1 | 2 | 3 | 3.1 | CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 15544720 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL18769 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 260 | 3796 | 49 | None | -45 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| 2775 | 3796 | 49 | None | -45 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| 656665 | 3796 | 49 | None | -45 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| CHEMBL56564 | 3796 | 49 | None | -45 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| DB11699 | 3796 | 49 | None | -45 | 6 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | nan | ||
| 15544720 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | ||
| CHEMBL18769 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | ||
| 15544720 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL18769 | 66817 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 2 | 2 | 3 | 2.0 | CN1CCC(NC(=O)c2cc(Cl)cc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 1782 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| 241 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| 4168 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| CHEMBL86 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| DB01233 | 2472 | 81 | None | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1021/jm020270n | ||
| 10408029 | 16268 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL123377 | 16268 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 6 | 1 | 6 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2)CC1 | 10.1021/jm0009538 | ||
| 10744356 | 11253 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 1.9 | C=CC[N+]1(C)CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL1179774 | 11253 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 1.9 | C=CC[N+]1(C)CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL99299 | 11253 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 1.9 | C=CC[N+]1(C)CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 90644474 | 111776 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 343 | 4 | 0 | 3 | 3.7 | O=C1c2cc(Cl)nc3cccc(c23)CN1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| CHEMBL3291079 | 111776 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 343 | 4 | 0 | 3 | 3.7 | O=C1c2cc(Cl)nc3cccc(c23)CN1CCCN1CCCCC1 | 10.1016/j.ejmech.2014.05.015 | ||
| 44288600 | 100635 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| CHEMBL295155 | 100635 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 2.0 | COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 | 10.1016/j.bmcl.2004.09.005 | ||
| 44592077 | 188713 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 329 | 6 | 0 | 5 | 4.2 | c1cc2c(OCCCCN3CCCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL512303 | 188713 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 329 | 6 | 0 | 5 | 4.2 | c1cc2c(OCCCCN3CCCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| 56850385 | 71118 | 0 | None | -72 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.1 | O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 | 10.1021/jm2007886 | ||
| CHEMBL1926730 | 71118 | 0 | None | -72 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.1 | O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 | 10.1021/jm2007886 | ||
| CHEMBL1962454 | 71118 | 0 | None | -72 | 3 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.1 | O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1 | 10.1021/jm2007886 | ||
| 3277217 | 178145 | 5 | None | -6 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 271 | 3 | 1 | 4 | 1.4 | O=C(O)CN1CCN(c2ccc3ccccc3n2)CC1 | 10.1021/jm900018b | ||
| 715494 | 178145 | 5 | None | -6 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 271 | 3 | 1 | 4 | 1.4 | O=C(O)CN1CCN(c2ccc3ccccc3n2)CC1 | 10.1021/jm900018b | ||
| CHEMBL468498 | 178145 | 5 | None | -6 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 271 | 3 | 1 | 4 | 1.4 | O=C(O)CN1CCN(c2ccc3ccccc3n2)CC1 | 10.1021/jm900018b | ||
| 11174673 | 173049 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 3 | 3 | 5 | 1.6 | Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCNCC3)c2n1 | 10.1016/j.ejmech.2019.111569 | ||
| CHEMBL4533922 | 173049 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 321 | 3 | 3 | 5 | 1.6 | Cc1cn2c(N)c(Cl)cc(C(=O)NCC3CCNCC3)c2n1 | 10.1016/j.ejmech.2019.111569 | ||
| 44592107 | 178497 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 301 | 3 | 0 | 5 | 3.3 | CN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL471661 | 178497 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 301 | 3 | 0 | 5 | 3.3 | CN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 11135810 | 204768 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 606 | 11 | 1 | 8 | 5.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | ||
| CHEMBL88355 | 204768 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 606 | 11 | 1 | 8 | 5.5 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCCCN2C(=O)c3cccc4c(N(C)C)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | ||
| 56850387 | 71119 | 0 | None | -13 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.2 | O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 | 10.1021/jm2007886 | ||
| CHEMBL1926731 | 71119 | 0 | None | -13 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.2 | O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 | 10.1021/jm2007886 | ||
| CHEMBL1962455 | 71119 | 0 | None | -13 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 1 | 3 | 3.2 | O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1 | 10.1021/jm2007886 | ||
| 44404955 | 132984 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 868 | 24 | 4 | 15 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCOCCOCCOCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL370796 | 132984 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 868 | 24 | 4 | 15 | 3.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCOCCOCCOCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 235 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1039/C8MD00233A | ||
| 5311299 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1039/C8MD00233A | ||
| CHEMBL286136 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1039/C8MD00233A | ||
| 42636941 | 178361 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 343 | 5 | 0 | 5 | 4.4 | CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1039/C2MD20063E | ||
| CHEMBL470432 | 178361 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 343 | 5 | 0 | 5 | 4.4 | CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1039/C2MD20063E | ||
| 235 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1039/C6MD00458J | ||
| 5311299 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1039/C6MD00458J | ||
| CHEMBL286136 | 2517 | 36 | None | -5 | 3 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1039/C6MD00458J | ||
| 10764565 | 48733 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCC[N+]12CCC(CC1)CC2 | 10.1021/jm960320m | ||
| CHEMBL156088 | 48733 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OCC[N+]12CCC(CC1)CC2 | 10.1021/jm960320m | ||
| 10548275 | 48232 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 307 | 5 | 1 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)OCC[n+]1ccccc1 | 10.1021/jm960320m | ||
| CHEMBL155631 | 48232 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 307 | 5 | 1 | 4 | 2.1 | COc1cc(N)c(Cl)cc1C(=O)OCC[n+]1ccccc1 | 10.1021/jm960320m | ||
| 162648923 | 179364 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 550 | 10 | 3 | 8 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc3c(c2)NC(=O)CO3)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4746550 | 179364 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 550 | 10 | 3 | 8 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc3c(c2)NC(=O)CO3)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 44371350 | 119650 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 5 | 1 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)OC(C)C1 | 10.1021/jm960320m | ||
| CHEMBL351570 | 119650 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 5 | 1 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)OC(C)C1 | 10.1021/jm960320m | ||
| 71451950 | 82249 | 5 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 49783208 | 17411 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258222 | 17411 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 3.0 | CCCCN1CCC(COC(=O)c2cc(C)c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 258 | 3498 | 25 | None | -1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/j.bmc.2008.11.045 | ||
| 5191 | 3498 | 25 | None | -1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL287045 | 3498 | 25 | None | -1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/j.bmc.2008.11.045 | ||
| 71712611 | 90932 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| CHEMBL2402887 | 90932 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 478 | 8 | 3 | 7 | -0.1 | CS(=O)(=O)N1CCN(CC(O)CN2CCC(CNC(=O)c3cccc4[nH]cnc34)CC2)CC1 | 10.1016/j.bmcl.2013.05.018 | ||
| 44248439 | 194508 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL561398 | 194508 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 4.2 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44592235 | 171989 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 343 | 4 | 0 | 5 | 4.4 | Cc1csc2nc(OCC3CCN(C(C)C)CC3)c3cccn3c12 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL448702 | 171989 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 343 | 4 | 0 | 5 | 4.4 | Cc1csc2nc(OCC3CCN(C(C)C)CC3)c3cccn3c12 | 10.1016/j.bmc.2008.11.045 | ||
| 10584 | 1430 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | ||
| 86582973 | 1430 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3417009 | 1430 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1021/acs.jmedchem.5b00115 | ||
| 10584 | 1430 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2019.02.076 | ||
| 86582973 | 1430 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2019.02.076 | ||
| CHEMBL3417009 | 1430 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2019.02.076 | ||
| 10666935 | 206201 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL97019 | 206201 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 5 | 1 | 6 | 1.7 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 71451950 | 82249 | 5 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| CHEMBL2179582 | 82249 | 5 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 433 | 4 | 2 | 5 | 2.4 | CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc21 | 10.1021/jm300953p | ||
| 11603514 | 71131 | 0 | None | -5 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | ||
| CHEMBL1926760 | 71131 | 0 | None | -5 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | ||
| CHEMBL1962492 | 71131 | 0 | None | -5 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 390 | 11 | 1 | 5 | 4.0 | O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1 | 10.1021/jm2007886 | ||
| 209710 | 101364 | 1 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1cccc(Cl)c1)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL300476 | 101364 | 1 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1cccc(Cl)c1)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| 44240743 | 6664 | 15 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 370 | 7 | 2 | 3 | 4.3 | O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1 | 10.1021/jm901692q | ||
| CHEMBL1083787 | 6664 | 15 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 370 | 7 | 2 | 3 | 4.3 | O=C(NCCCCN1CCCCC1)Nc1ccc(-c2ccc(F)cc2)nc1 | 10.1021/jm901692q | ||
| 136118651 | 75956 | 0 | None | -1 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058706 | 75956 | 0 | None | -1 | 5 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 1 | 3 | 2 | 2.0 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 145955685 | 161906 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 602 | 17 | 6 | 10 | 0.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCNC(=O)NCC(=O)O)CC1 | 10.1039/C6MD00458J | ||
| CHEMBL4167048 | 161906 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 602 | 17 | 6 | 10 | 0.3 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCNC(=O)NCC(=O)O)CC1 | 10.1039/C6MD00458J | ||
| 44592039 | 187704 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 301 | 4 | 1 | 5 | 3.5 | c1cc2c(OCCC3CCCCN3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL500336 | 187704 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 301 | 4 | 1 | 5 | 3.5 | c1cc2c(OCCC3CCCCN3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| 260 | 3796 | 49 | None | -19 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | ||
| 2775 | 3796 | 49 | None | -19 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | ||
| 656665 | 3796 | 49 | None | -19 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | ||
| CHEMBL56564 | 3796 | 49 | None | -19 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | ||
| DB11699 | 3796 | 49 | None | -19 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 10.1016/0960-894X(96)00200-4 | ||
| 76313431 | 102882 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 330 | 2 | 2 | 5 | 1.5 | COc1ccc2[nH]c(=O)n(C(=O)N[C@H]3C[C@@H]4CC[C@H](C3)N4C)c2c1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL3084582 | 102882 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 330 | 2 | 2 | 5 | 1.5 | COc1ccc2[nH]c(=O)n(C(=O)N[C@H]3C[C@@H]4CC[C@H](C3)N4C)c2c1 | 10.1016/j.bmc.2008.11.045 | ||
| 9839803 | 92426 | 0 | None | -1 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.2 | O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440452 | 92426 | 0 | None | -1 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.2 | O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| 9839803 | 92426 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.2 | O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440452 | 92426 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 3 | 2 | 4 | 2.2 | O=C(NCC1CCNCC1)c1c2n(c3ccccc13)CCCO2 | 10.1016/j.bmc.2013.09.004 | ||
| 44592284 | 178439 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.8 | c1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL471231 | 178439 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.8 | c1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1016/j.bmc.2008.11.045 | ||
| 10757502 91929739 | 193445 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL550064 | 193445 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 10757502 91929739 | 193445 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550064 | 193445 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 3 | 2 | 4 | 2.6 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)c2ccccc21 | 10.1021/jm900881j | ||
| 44248312 91900490 | 193450 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL550122 | 193450 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 531 | 12 | 2 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCCCCS(=O)(=O)O)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248187 91900482 | 193700 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL551941 | 193700 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | CCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 44247811 | 193790 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL552693 | 193790 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 369 | 8 | 3 | 5 | 2.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCO)CC1 | 10.1021/jm900881j | ||
| 44249056 91900483 | 194653 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| CHEMBL562400 | 194653 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 451 | 10 | 1 | 4 | 5.7 | CCCCCCCCN1[C@H]2CC[C@@H]1C[C@H](NC(=O)c1cc3ccccc3n(C(C)C)c1=O)C2 | 10.1021/jm900881j | ||
| 10574402 91900484 | 194788 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL563261 | 194788 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 425 | 8 | 2 | 5 | 3.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCCCO)cc2ccccc21 | 10.1021/jm900881j | ||
| 44248433 91900494 | 195056 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL565146 | 195056 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 1.9 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCN(S(C)(=O)=O)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 131725 | 198743 | 2 | None | 3 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL59834 | 198743 | 2 | None | 3 | 2 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 342 | 2 | 1 | 5 | 2.6 | CC(C)n1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | 10.1021/jm981098j | ||
| 44247947 | 193653 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| CHEMBL551678 | 193653 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 433 | 9 | 3 | 6 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCS(=O)(=O)O)CC1 | 10.1021/jm900881j | ||
| 3168 | 9157 | 84 | None | -93 | 22 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| CHEMBL1108 | 9157 | 84 | None | -93 | 22 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | nan | ||
| 10347130 | 204305 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | ||
| CHEMBL85125 | 204305 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 536 | 7 | 2 | 8 | 3.8 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CN2C(=O)c3cccc4c(N)ccc(c34)C2=O)CC1 | 10.1021/jm0307887 | ||
| 10812045 | 15331 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121766 | 15331 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 1 | 7 | 2.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1 | 10.1021/jm0009538 | ||
| 14403199 | 116097 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL33676 | 116097 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1016/S0960-894X(01)80508-4 | ||
| 14403199 | 116097 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1021/jm960320m | ||
| CHEMBL33676 | 116097 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.7 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C | 10.1021/jm960320m | ||
| 10530233 | 11237 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 402 | 7 | 1 | 5 | 2.5 | CCCC[N+]1(C)CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL1179716 | 11237 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 402 | 7 | 1 | 5 | 2.5 | CCCC[N+]1(C)CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL95968 | 11237 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 402 | 7 | 1 | 5 | 2.5 | CCCC[N+]1(C)CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 10381927 | 162537 | 1 | None | -16 | 3 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 329 | 1 | 0 | 3 | 3.8 | CN1CCN(c2nc3ccccc3c3c2CCc2ccccc2-3)CC1 | 10.1021/jm00014a021 | ||
| CHEMBL417706 | 162537 | 1 | None | -16 | 3 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 329 | 1 | 0 | 3 | 3.8 | CN1CCN(c2nc3ccccc3c3c2CCc2ccccc2-3)CC1 | 10.1021/jm00014a021 | ||
| 11799162 | 11248 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 360 | 4 | 1 | 5 | 1.3 | CC(C)n1c(=O)n(C(=O)NCCN2CC[N+](C)(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL1179748 | 11248 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 360 | 4 | 1 | 5 | 1.3 | CC(C)n1c(=O)n(C(=O)NCCN2CC[N+](C)(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL97903 | 11248 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 360 | 4 | 1 | 5 | 1.3 | CC(C)n1c(=O)n(C(=O)NCCN2CC[N+](C)(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| 21588627 | 106127 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL314299 | 106127 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 21588627 | 106127 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1021/jm020807x | ||
| CHEMBL314299 | 106127 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1021/jm020807x | ||
| 21588627 | 106127 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL314299 | 106127 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 7 | 1 | 4 | 4.8 | CC(C)CN1CCC(CNC(=O)c2cc(Cl)cc3c2ncn3Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020270n | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020270n | ||
| 242 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020270n | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020270n | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020270n | ||
| 10335971 | 100429 | 1 | None | -15 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 317 | 1 | 0 | 4 | 3.9 | CN1CCN(c2nc3ccccc3c3c2oc2ccccc23)CC1 | 10.1021/jm00014a021 | ||
| CHEMBL293866 | 100429 | 1 | None | -15 | 2 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 317 | 1 | 0 | 4 | 3.9 | CN1CCN(c2nc3ccccc3c3c2oc2ccccc23)CC1 | 10.1021/jm00014a021 | ||
| 71450246 | 82545 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 348 | 5 | 0 | 3 | 5.2 | CCCN1CCC(COc2nc3cc(C)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181184 | 82545 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 348 | 5 | 0 | 3 | 5.2 | CCCN1CCC(COc2nc3cc(C)ccc3c3ccccc23)CC1 | 10.1021/jm300943r | ||
| 44404958 | 72047 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL198719 | 72047 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 3.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| 11813852 | 111512 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 574 | 10 | 2 | 8 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL328918 | 111512 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 574 | 10 | 2 | 8 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 11596009 | 73012 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 3 | 1 | 5 | 2.4 | CC(C)n1c(=O)n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| CHEMBL201414 | 73012 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 342 | 3 | 1 | 5 | 2.4 | CC(C)n1c(=O)n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2ccccc21 | 10.1021/jm0509501 | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 49783211 | 17443 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258339 | 17443 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(I)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 11005668 | 204906 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 504 | 9 | 2 | 11 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNc2ccc([N+](=O)[O-])c3nonc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL89225 | 204906 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 504 | 9 | 2 | 11 | 3.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNc2ccc([N+](=O)[O-])c3nonc23)CC1 | 10.1021/jm0307887 | ||
| 71462777 | 82538 | 0 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| CHEMBL2181171 | 82538 | 0 | None | 1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 5 | 0 | 4 | 4.3 | CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1 | 10.1021/jm300943r | ||
| 10788092 | 53291 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 416 | 7 | 1 | 6 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm960320m | ||
| CHEMBL160237 | 53291 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 416 | 7 | 1 | 6 | 3.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)c2ccccc2)CC1 | 10.1021/jm960320m | ||
| 162645470 | 178954 | 0 | None | 107 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 536 | 11 | 3 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(NC(C)=O)cc2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4741579 | 178954 | 0 | None | 107 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 536 | 11 | 3 | 7 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2ccc(NC(C)=O)cc2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 10449091 | 119447 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1C | 10.1021/jm960320m | ||
| CHEMBL349809 | 119447 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 326 | 5 | 1 | 5 | 3.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1C | 10.1021/jm960320m | ||
| 49780155 | 16944 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 393 | 7 | 1 | 8 | 2.6 | CCCCN1CCC(COC(=O)c2cc([N+](=O)[O-])c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1255606 | 16944 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 393 | 7 | 1 | 8 | 2.6 | CCCCN1CCC(COC(=O)c2cc([N+](=O)[O-])c(N)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 44629280 | 82299 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 0 | 4 | 4.6 | CCCCN1CCC(COc2nc3ccccc3c3cn(C)cc23)CC1 | 10.1021/jm300573d | ||
| CHEMBL2179679 | 82299 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 0 | 4 | 4.6 | CCCCN1CCC(COc2nc3ccccc3c3cn(C)cc23)CC1 | 10.1021/jm300573d | ||
| 11627949 | 76053 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| CHEMBL2059587 | 76053 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 532 | 8 | 2 | 8 | 1.3 | CC(C)n1nc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C[C@H](O)CN2CCN(S(C)(=O)=O)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.034 | ||
| 44248193 | 193131 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| CHEMBL538956 | 193131 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 593 | 12 | 1 | 7 | 5.0 | CCOC(=O)N1CCN(CCCCCCCN2[C@H]3CC[C@@H]2C[C@H](NC(=O)c2cc4ccccc4n(C(C)C)c2=O)C3)CC1 | 10.1021/jm900881j | ||
| 21252890 | 193795 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 4 | 2 | 4 | 2.3 | CC(C)n1nc(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL552796 | 193795 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 4 | 2 | 4 | 2.3 | CC(C)n1nc(C(=O)NCC2CCNCC2)c2ccccc21 | 10.1021/jm900881j | ||
| 44248321 | 193898 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL555222 | 193898 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 541 | 8 | 1 | 6 | 4.5 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCCN2CCN(c3ccccc3)CC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 10717193 | 16588 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL124485 | 16588 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm0009538 | ||
| 15544714 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| CHEMBL18473 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1021/jm020807x | ||
| 15544714 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | ||
| CHEMBL18473 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/0960-894X(96)00200-4 | ||
| 15544714 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL18473 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 1471834 | 3559 | 36 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 10.1021/jm060001n | ||
| 6126 | 3559 | 36 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 10.1021/jm060001n | ||
| CHEMBL210288 | 3559 | 36 | None | -4 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 366 | 2 | 0 | 2 | 5.5 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 | 10.1021/jm060001n | ||
| 15544714 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| CHEMBL18473 | 65936 | 4 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 258 | 2 | 2 | 3 | 1.4 | CN1CCC(NC(=O)c2cccc3[nH]cnc23)CC1 | 10.1016/s0960-894x(01)00517-0 | ||
| 30049 | 187610 | 1 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL49907 | 187610 | 1 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 282 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| 15485875 | 188133 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 301 | 5 | 0 | 5 | 3.4 | c1cc2c(OCCCN3CCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL504904 | 188133 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 301 | 5 | 0 | 5 | 3.4 | c1cc2c(OCCCN3CCCC3)nc3ccsc3n2c1 | 10.1016/j.bmc.2008.11.045 | ||
| 10664258 | 206617 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 331 | 4 | 1 | 6 | 0.6 | CCn1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL99515 | 206617 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 331 | 4 | 1 | 6 | 0.6 | CCn1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| 90665998 | 108783 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 405 | 7 | 0 | 5 | 5.3 | c1ccc(CCCN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| CHEMBL3218870 | 108783 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 405 | 7 | 0 | 5 | 5.3 | c1ccc(CCCN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| 108182 | 4055 | 18 | None | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 245 | 4055 | 18 | None | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL18041 | 4055 | 18 | None | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 10.1016/S0960-894X(01)80508-4 | ||
| 139188853 | 166318 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 6 | 2 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2ccc3cccc(O)c3n2)CC1 | 10.1039/C8MD00233A | ||
| CHEMBL4285988 | 166318 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 6 | 2 | 4 | 3.2 | CCCCN1CCC(CNC(=O)c2ccc3cccc(O)c3n2)CC1 | 10.1039/C8MD00233A | ||
| 11966400 | 205107 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 588 | 11 | 2 | 8 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL90559 | 205107 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 588 | 11 | 2 | 8 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 10779499 | 37826 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 285 | 2 | 3 | 4 | 1.0 | Nc1ccc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | ||
| CHEMBL146068 | 37826 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 285 | 2 | 3 | 4 | 1.0 | Nc1ccc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 | 10.1021/jm991076c | ||
| 44247808 | 193699 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| CHEMBL551940 | 193699 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 395 | 10 | 2 | 4 | 4.5 | CCCCCCCCN1CCC(NC(=O)c2cc(Cl)c(N)cc2OC)CC1 | 10.1021/jm900881j | ||
| 44247813 | 193909 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | ||
| CHEMBL555447 | 193909 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 411 | 11 | 3 | 5 | 3.5 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCCCCO)CC1 | 10.1021/jm900881j | ||
| 10837280 91900491 | 194139 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL558259 | 194139 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 3.8 | CC(C)n1c(=O)c(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN2CCCCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 9857899 | 121646 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 3.3 | CN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| CHEMBL35972 | 121646 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 311 | 3 | 1 | 4 | 3.3 | CN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1 | 10.1021/jm020954v | ||
| 90666007 | 108790 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 383 | 5 | 0 | 5 | 5.2 | c1cc2c(OCC3CCN(CC4CCCCC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| CHEMBL3218879 | 108790 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 383 | 5 | 0 | 5 | 5.2 | c1cc2c(OCC3CCN(CC4CCCCC4)CC3)nc3ccsc3n2c1 | 10.1039/C2MD20063E | ||
| 73354085 | 92425 | 0 | None | -1 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2c3n(c4cc(O)ccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440451 | 92425 | 0 | None | -1 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2c3n(c4cc(O)ccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| 73354085 | 92425 | 0 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2c3n(c4cc(O)ccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| CHEMBL2440451 | 92425 | 0 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 385 | 6 | 2 | 5 | 3.4 | CCCCN1CCC(CNC(=O)c2c3n(c4cc(O)ccc24)CCCO3)CC1 | 10.1016/j.bmc.2013.09.004 | ||
| 44249186 | 193636 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| CHEMBL551535 | 193636 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 327 | 4 | 2 | 4 | 2.3 | CC(C)n1c(=O)c(C(=O)NCC2CCNCC2)cc2ccccc21 | 10.1021/jm900881j | ||
| 44247815 | 194791 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| CHEMBL563276 | 194791 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 6 | 2 | 6 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCN2C(=O)c3ccccc3C2=O)CC1 | 10.1021/jm900881j | ||
| 24865727 | 192501 | 0 | None | -5011 | 11 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | ||
| CHEMBL522708 | 192501 | 0 | None | -5011 | 11 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | ||
| 11686414 | 71390 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 4 | 12 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL196633 | 71390 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 4 | 12 | 3.6 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 44404966 | 132915 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL370646 | 132915 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 834 | 22 | 5 | 12 | 5.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C(=O)NCCCCCCCCCCNC(=O)C2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| 145990064 | 166405 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 6 | 1 | 6 | 2.1 | COc1cc(C(=O)OCCN2CCC(CO)CC2)c2ccccc2n1 | 10.1039/C8MD00233A | ||
| CHEMBL4287473 | 166405 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 6 | 1 | 6 | 2.1 | COc1cc(C(=O)OCCN2CCC(CO)CC2)c2ccccc2n1 | 10.1039/C8MD00233A | ||
| 9800656 | 15360 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL121913 | 15360 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ncccn2)CC1 | 10.1021/jm0009538 | ||
| 11726706 | 205980 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 371 | 6 | 1 | 6 | 1.7 | CCCN1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL95661 | 205980 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 371 | 6 | 1 | 6 | 1.7 | CCCN1CCN(CCNC(=O)n2c(=O)n(C3CC3)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 162658420 | 180508 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 539 | 12 | 2 | 8 | 3.6 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1OC | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4760149 | 180508 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 539 | 12 | 2 | 8 | 3.6 | COc1ccc(S(=O)(=O)NCCN2CCC(CCC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1OC | 10.1016/j.ejmech.2016.05.048 | ||
| 118734514 | 118152 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3416999 | 118152 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 5.6 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCC2CCCCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 44323264 | 205373 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL92100 | 205373 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10.1021/jm0009538 | ||
| 44592281 | 188819 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 5 | 0 | 5 | 4.1 | C=CCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL513254 | 188819 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 341 | 5 | 0 | 5 | 4.1 | C=CCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 162675700 | 182869 | 0 | None | 16 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 650 | 10 | 3 | 7 | 4.7 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2cc(Br)c(N)c(Br)c2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| CHEMBL4799043 | 182869 | 0 | None | 16 | 2 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 650 | 10 | 3 | 7 | 4.7 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(=O)(=O)c2cc(Br)c(N)c(Br)c2)CC1 | 10.1016/j.ejmech.2016.05.048 | ||
| 44592144 | 178265 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 5 | 0 | 5 | 3.8 | C=CCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL469575 | 178265 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 327 | 5 | 0 | 5 | 3.8 | C=CCN1CCC(COc2nc3ccsc3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 118734509 | 118149 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL3416995 | 118149 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 4.4 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CC2CCC2)CC1 | 10.1021/acs.jmedchem.5b00115 | ||
| 151758 | 188737 | 4 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL51251 | 188737 | 4 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 278 | 5 | 1 | 4 | 2.7 | COc1ccccc1NC(=O)OCCN1CCCCC1 | 10.1021/jm960853v | ||
| 10541689 | 101570 | 4 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | COc1ccccc1NC(=O)OCCCN1CCCCC1 | 10.1021/jm960853v | ||
| CHEMBL301967 | 101570 | 4 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 292 | 6 | 1 | 4 | 3.1 | COc1ccccc1NC(=O)OCCCN1CCCCC1 | 10.1021/jm960853v | ||
| 107715 | 199250 | 18 | None | -165 | 20 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | ||
| CHEMBL1255837 | 199250 | 18 | None | -165 | 20 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | ||
| CHEMBL601773 | 199250 | 18 | None | -165 | 20 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | nan | ||
| 44299805 | 100602 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC1CN2C | 10.1016/s0960-894x(01)00693-x | ||
| CHEMBL294894 | 100602 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 324 | 3 | 1 | 5 | 2.6 | COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC1CN2C | 10.1016/s0960-894x(01)00693-x | ||
| 44573 | 56683 | 1 | None | -1 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 297 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C)CC1 | 10.1016/0960-894X(95)00115-A | ||
| CHEMBL164425 | 56683 | 1 | None | -1 | 2 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 297 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C)CC1 | 10.1016/0960-894X(95)00115-A | ||
| 44573 | 56683 | 1 | None | 1 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 297 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C)CC1 | 10.1021/jm020270n | ||
| CHEMBL164425 | 56683 | 1 | None | 1 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 297 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(C)CC1 | 10.1021/jm020270n | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020099f | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020099f | ||
| 242 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020099f | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020099f | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10.1021/jm020099f | ||
| 49783416 | 17516 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 319 | 7 | 2 | 4 | 2.5 | CCCCN1CCC(CNC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258559 | 17516 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 319 | 7 | 2 | 4 | 2.5 | CCCCN1CCC(CNC(=O)c2ccc(N)c(OC)c2)CC1 | 10.1021/jm100668r | ||
| 12861897 | 76723 | 0 | None | -35 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 347 | 7 | 2 | 4 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)NCCN(C)Cc1ccccc1 | 10.1021/jm020270n | ||
| CHEMBL20748 | 76723 | 0 | None | -35 | 2 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 347 | 7 | 2 | 4 | 2.8 | COc1cc(N)c(Cl)cc1C(=O)NCCN(C)Cc1ccccc1 | 10.1021/jm020270n | ||
| 10761897 | 205999 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 6 | 1 | 6 | 2.0 | CCCN1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL95808 | 205999 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 6 | 1 | 6 | 2.0 | CCCN1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 10761898 | 205899 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 5 | 1 | 6 | 2.0 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| CHEMBL95235 | 205899 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 373 | 5 | 1 | 6 | 2.0 | CC(C)N1CCN(CCNC(=O)n2c(=O)n(C(C)C)c3ccccc32)CC1 | 10.1021/jm981098j | ||
| 45276946 | 19147 | 0 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 4 | 0 | 5 | 3.6 | C#CCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.ejmech.2010.07.052 | ||
| CHEMBL1290804 | 19147 | 0 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 339 | 4 | 0 | 5 | 3.6 | C#CCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.ejmech.2010.07.052 | ||
| 44404961 | 132480 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL370227 | 132480 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 764 | 17 | 5 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)CCCCCC(=O)NC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3O)CC2)CC1 | 10.1021/jm050234z | ||
| 11693471 | 134703 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 778 | 18 | 4 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| CHEMBL372479 | 134703 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 778 | 18 | 4 | 12 | 4.0 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CNC(=O)CCCC(=O)NCC2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)CC1 | 10.1021/jm050234z | ||
| 72698087 | 103498 | 0 | None | -81 | 3 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 5.0 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL3093186 | 103498 | 0 | None | -81 | 3 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 407 | 5 | 0 | 4 | 5.0 | Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL4164469 | 211462 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(NC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)NCCCN(C)CCCNC(=O)NCc3cn(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)NC4CCN(CCOC(=O)c5cc(Cl)c(N)cc5OC)CC4)nn3)nn2)CC1 | 10.1039/C6MD00458J | ||||
| 10757373 | 49306 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 310 | 5 | 1 | 5 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC=CCC1 | 10.1021/jm960320m | ||
| CHEMBL156579 | 49306 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 310 | 5 | 1 | 5 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CC=CCC1 | 10.1021/jm960320m | ||
| 49783207 | 17381 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| CHEMBL1258109 | 17381 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.2 | CCCCN1CCC(COC(=O)c2ccc(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | ||
| 11794824 | 17739 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cncnc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL125926 | 17739 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 391 | 6 | 1 | 8 | 1.7 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cncnc2)CC1 | 10.1021/jm0009538 | ||
| 44371317 | 49778 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C2CCCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL156965 | 49778 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 338 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(Cl)cc1C(=O)OCCN1C2CCCC1CC2 | 10.1021/jm960320m | ||
| 183782 | 3334 | 15 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/acs.jmedchem.5b00115 | ||
| 237 | 3334 | 15 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/acs.jmedchem.5b00115 | ||
| CHEMBL85251 | 3334 | 15 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1021/acs.jmedchem.5b00115 | ||
| 183782 | 3334 | 15 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2018.10.064 | ||
| 237 | 3334 | 15 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL85251 | 3334 | 15 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10.1016/j.ejmech.2018.10.064 | ||
| 10584 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | ||
| 86582973 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | ||
| CHEMBL3417009 | 1430 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 10.1016/j.ejmech.2018.10.064 | ||
| 44592188 | 188660 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 329 | 4 | 0 | 5 | 4.0 | CCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| CHEMBL511794 | 188660 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 329 | 4 | 0 | 5 | 4.0 | CCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 | 10.1016/j.bmc.2008.11.045 | ||
| 9927789 | 111001 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL327798 | 111001 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 337 | 5 | 2 | 4 | 2.5 | Nc1c(Cl)cc(C(=O)NCCCN2CCCCC2)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 10526438 | 17098 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnc(Cl)nc2)CC1 | 10.1021/jm0009538 | ||
| CHEMBL125716 | 17098 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 425 | 6 | 1 | 8 | 2.4 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cnc(Cl)nc2)CC1 | 10.1021/jm0009538 | ||
| 1782 | 2472 | 81 | None | -11 | 23 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 241 | 2472 | 81 | None | -11 | 23 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 4168 | 2472 | 81 | None | -11 | 23 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL86 | 2472 | 81 | None | -11 | 23 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| DB01233 | 2472 | 81 | None | -11 | 23 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(96)00002-9 | ||
| 10688893 | 206636 | 0 | None | -1 | 2 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| CHEMBL99591 | 206636 | 0 | None | -1 | 2 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.2 | CC(C)n1c(=O)n(C(=O)NCCN2CCN(C)CC2)c2ccccc21 | 10.1021/jm981098j | ||
| 10828800 | 99713 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL288199 | 99713 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1016/S0960-894X(01)80508-4 | ||
| 10828800 | 99713 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| CHEMBL288199 | 99713 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 310 | 3 | 1 | 5 | 2.2 | COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2 | 10.1021/jm960320m | ||
| 72698086 | 103497 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 5 | 0 | 4 | 4.3 | Fc1cccc2c1nc(OCC1CCN(CC(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| CHEMBL3093185 | 103497 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 5 | 0 | 4 | 4.3 | Fc1cccc2c1nc(OCC1CCN(CC(F)F)CC1)c1cccnc12 | 10.1016/j.bmc.2013.08.061 | ||
| 75201901 | 165861 | 14 | None | -676 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| CHEMBL4277264 | 165861 | 14 | None | -676 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | ||
| 136118647 | 75952 | 0 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 240 | 1 | 3 | 2 | 1.2 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| CHEMBL2058702 | 75952 | 0 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 240 | 1 | 3 | 2 | 1.2 | C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1 | 10.1016/j.bmc.2013.09.011 | ||
| 44323245 | 106528 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| CHEMBL315443 | 106528 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 322 | 2 | 1 | 5 | 2.1 | Nc1c(Cl)cc(C(=O)O[C@H]2CN3CCC2CC3)c2c1CCO2 | 10.1016/0960-894X(96)00002-9 | ||
| 10930618 | 106543 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 729 | 19 | 2 | 9 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| CHEMBL315526 | 106543 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 729 | 19 | 2 | 9 | 5.9 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(C(=O)CCCCCCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)CC1 | 10.1021/jm0307887 | ||
| 6918107 | 77772 | 13 | None | -1 | 5 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 319 | 2 | 0 | 4 | 3.5 | Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O | 10.1021/jm00075a026 | ||
| CHEMBL2103778 | 77772 | 13 | None | -1 | 5 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 319 | 2 | 0 | 4 | 3.5 | Cc1nccn1C[C@H]1CCc2c(c3cccc4c3n2CCC4)C1=O | 10.1021/jm00075a026 | ||
| 1782 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | ||
| 241 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | ||
| 4168 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | ||
| CHEMBL86 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | ||
| DB01233 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/0960-894X(95)00115-A | ||
| 1782 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| 241 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| 4168 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| CHEMBL86 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| DB01233 | 2472 | 81 | None | -11 | 23 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 10.1016/S0960-894X(01)80508-4 | ||
| 90666001 | 108784 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 395 | 5 | 0 | 5 | 5.0 | Fc1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| CHEMBL3218873 | 108784 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 395 | 5 | 0 | 5 | 5.0 | Fc1ccc(CN2CCC(COc3nc4ccsc4n4cccc34)CC2)cc1 | 10.1039/C2MD20063E | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 8.6 | pKd | = | 8.6 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| 236 | 3333 | 0 | None | -4 | 2 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 239 | 3333 | 0 | None | -4 | 2 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 5311417 | 3333 | 0 | None | -4 | 2 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| CHEMBL1908857 | 3333 | 0 | None | -4 | 2 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 236 | 3333 | 0 | None | 4 | 2 | Guinea pig | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 239 | 3333 | 0 | None | 4 | 2 | Guinea pig | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 5311417 | 3333 | 0 | None | 4 | 2 | Guinea pig | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| CHEMBL1908857 | 3333 | 0 | None | 4 | 2 | Guinea pig | 9.7 | pKd | = | 9.7 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 121881 | 3421 | 21 | 3H-GR-113808 | 2 | 15 | Guinea pig | 11.0 | pKi | = | 11 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 256 | 3421 | 21 | 3H-GR-113808 | 2 | 15 | Guinea pig | 11.0 | pKi | = | 11 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| CHEMBL68131 | 3421 | 21 | 3H-GR-113808 | 2 | 15 | Guinea pig | 11.0 | pKi | = | 11 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 10.7 | pKi | = | 10.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 121881 | 3421 | 21 | 3H-GR-113808 | 2 | 15 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 256 | 3421 | 21 | 3H-GR-113808 | 2 | 15 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| CHEMBL68131 | 3421 | 21 | 3H-GR-113808 | 2 | 15 | Guinea pig | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 10.1 | pKi | = | 10.1 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 121881 | 3421 | 21 | 3H-GR-113808 | -2 | 15 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 256 | 3421 | 21 | 3H-GR-113808 | -2 | 15 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| CHEMBL68131 | 3421 | 21 | 3H-GR-113808 | -2 | 15 | Human | 10.0 | pKi | = | 10 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Mouse | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Mouse | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Mouse | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Mouse | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Mouse | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -1 | 27 | Mouse | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 121881 | 3421 | 21 | 3H-RS 57639 | -27 | 15 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 256 | 3421 | 21 | 3H-RS 57639 | -27 | 15 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| CHEMBL68131 | 3421 | 21 | 3H-RS 57639 | -27 | 15 | Rat | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | 1 | 27 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 121881 | 3421 | 21 | 3H-GR-113808 | -27 | 15 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 256 | 3421 | 21 | 3H-GR-113808 | -27 | 15 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| CHEMBL68131 | 3421 | 21 | 3H-GR-113808 | -27 | 15 | Rat | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 121881 | 3421 | 21 | 3H-5HT | -27 | 15 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| 256 | 3421 | 21 | 3H-5HT | -27 | 15 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| CHEMBL68131 | 3421 | 21 | 3H-5HT | -27 | 15 | Rat | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | ||
| None | 214246 | 0 | 3H-GR-113808 | 251 | 14 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 453 | 9 | 2 | 6 | 2.6 | COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl | None | ||
| 119376 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-GR-113808 | -2 | 27 | Rat | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 183782 | 3334 | 15 | 3H-GR-113808 | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 237 | 3334 | 15 | 3H-GR-113808 | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL85251 | 3334 | 15 | 3H-GR-113808 | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 240 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| None | 214227 | 0 | 3H-GR-113808 | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 108182 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 57174031 | 214153 | 0 | 3H-5HT | -33 | 20 | Rat | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | -1 | 5 | Guinea pig | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 1809 | 134 | 28 | 3H-5HT | -46773 | 37 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-5HT | -46773 | 37 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-5HT | -46773 | 37 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1220 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| 31 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| 7 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| CHEMBL56 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| 202 | 1475 | 0 | UNDEFINED | -9 | 33 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 60835 | 1475 | 0 | UNDEFINED | -9 | 33 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 972 | 1475 | 0 | UNDEFINED | -9 | 33 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| CHEMBL1175 | 1475 | 0 | UNDEFINED | -9 | 33 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| DB00476 | 1475 | 0 | UNDEFINED | -9 | 33 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | ||
| 1524 | 2141 | 89 | 3H-GR-113808 | -776 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 197 | 2141 | 89 | 3H-GR-113808 | -776 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 3822 | 2141 | 89 | 3H-GR-113808 | -776 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 88 | 2141 | 89 | 3H-GR-113808 | -776 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| CHEMBL51 | 2141 | 89 | 3H-GR-113808 | -776 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| DB12465 | 2141 | 89 | 3H-GR-113808 | -776 | 52 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | ||
| 1621 | 2386 | 16 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 17 | 2386 | 16 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 5761 | 2386 | 16 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| CHEMBL263881 | 2386 | 16 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| DB04829 | 2386 | 16 | 3H-GR-113808 | -3235 | 45 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | ||
| 2543 | 3638 | 66 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | ||
| 5358 | 3638 | 66 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | ||
| 54 | 3638 | 66 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | ||
| CHEMBL128 | 3638 | 66 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | ||
| DB00669 | 3638 | 66 | 3H-GR-113808 | -281 | 32 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 108182 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 5656 | 201368 | 82 | UNDEFINED | -7 | 43 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| CHEMBL637 | 201368 | 82 | UNDEFINED | -7 | 43 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | ||
| 54841 | 201428 | 51 | UNDEFINED | -1 | 30 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| CHEMBL641 | 201428 | 51 | UNDEFINED | -1 | 30 | Guinea pig | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 255 | 6 | 1 | 2 | 3.7 | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 | None | ||
| None | 214619 | 0 | UNDEFINED | -1122 | 11 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 243 | 3 | 1 | 4 | 2.7 | CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N | None | ||
| None | 215332 | 0 | UNDEFINED | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 394 | 5 | 1 | 4 | 5.1 | CC1=CC(=C(C=C1)OC)NC(=O)OC2CC3CCCC(C2)N3CC4=CC=CC=C4 | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -87096 | 37 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -87096 | 37 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -87096 | 37 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 1220 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| 31 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| 7 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| CHEMBL56 | 186 | 46 | 3H-GR-113808 | -2511 | 45 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | ||
| 179 | 396 | 107 | 3H-GR-113808 | -4365 | 51 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 2159 | 396 | 107 | 3H-GR-113808 | -4365 | 51 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 963 | 396 | 107 | 3H-GR-113808 | -4365 | 51 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| CHEMBL243712 | 396 | 107 | 3H-GR-113808 | -4365 | 51 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| DB06288 | 396 | 107 | 3H-GR-113808 | -4365 | 51 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | ||
| 2477 | 732 | 54 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
| 36 | 732 | 54 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
| 437 | 732 | 54 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
| CHEMBL49 | 732 | 54 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
| DB00490 | 732 | 54 | 3H-GR-113808 | -1548 | 29 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 385 | 6 | 0 | 6 | 2.1 | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 | None | ||
| 135398737 | 942 | 89 | 3H-GR-113808 | -4168 | 92 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 38 | 942 | 89 | 3H-GR-113808 | -4168 | 92 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 722 | 942 | 89 | 3H-GR-113808 | -4168 | 92 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| CHEMBL42 | 942 | 89 | 3H-GR-113808 | -4168 | 92 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| DB00363 | 942 | 89 | 3H-GR-113808 | -4168 | 92 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | ||
| 107780 | 1806 | 50 | 3H-5HT | -10715 | 18 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | ||
| 14 | 1806 | 50 | 3H-5HT | -10715 | 18 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | ||
| CHEMBL15928 | 1806 | 50 | 3H-5HT | -10715 | 18 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | ||
| 1353 | 1872 | 85 | 3H-GR-113808 | -6918 | 86 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 3559 | 1872 | 85 | 3H-GR-113808 | -6918 | 86 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 86 | 1872 | 85 | 3H-GR-113808 | -6918 | 86 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| CHEMBL54 | 1872 | 85 | 3H-GR-113808 | -6918 | 86 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| DB00502 | 1872 | 85 | 3H-GR-113808 | -6918 | 86 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | ||
| 2402 | 3306 | 58 | 3H-GR-113808 | -660 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| 5095 | 3306 | 58 | 3H-GR-113808 | -660 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| 7295 | 3306 | 58 | 3H-GR-113808 | -660 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| CHEMBL589 | 3306 | 58 | 3H-GR-113808 | -660 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| DB00268 | 3306 | 58 | 3H-GR-113808 | -660 | 25 | Guinea pig | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | ||
| 1150 | 3805 | 116 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | ||
| 125 | 3805 | 116 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | ||
| CHEMBL6640 | 3805 | 116 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | ||
| DB08653 | 3805 | 116 | 3H-5HT | -436 | 25 | Mouse | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | ||
| 44208932 | 140163 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| CHEMBL381689 | 140163 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| None | 214561 | 0 | 3H-GR-113808 | -331 | 6 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 390 | 4 | 1 | 4 | 3.2 | C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)C(F)(F)F | None | ||
| None | 214693 | 0 | Functional | -660 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | ||
| None | 214693 | 0 | UNDEFINED | -660 | 28 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 107 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | 1 | 5 | Rat | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 4595 | 176131 | 102 | 3H-GR113808 | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | ||
| CHEMBL46 | 176131 | 102 | 3H-GR113808 | -3 | 15 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 108182 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | -1 | 5 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 108182 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 130946 | 201061 | 2 | UNDEFINED | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | None | ||
| CHEMBL62023 | 201061 | 2 | UNDEFINED | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(C(=O)NC2CC3CCC(C2)N3C)c2ccccc21 | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | -1 | 5 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 108182 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 152 | 361 | 18 | 3H-GR-113808 | -89 | 19 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| 2107 | 361 | 18 | 3H-GR-113808 | -89 | 19 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| CHEMBL275854 | 361 | 18 | 3H-GR-113808 | -89 | 19 | Rat | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 240 | 929 | 39 | 3H-RS 57639 | -8 | 25 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-RS 57639 | -8 | 25 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-RS 57639 | -8 | 25 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-RS 57639 | -8 | 25 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-RS 57639 | -8 | 25 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-RS 57639 | -8 | 25 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-RS 57639 | -8 | 25 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -8 | 20 | Mouse | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| None | 214227 | 0 | 3H-RS 57639 | -2 | 6 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 152 | 361 | 18 | 3H-GR-113808 | -208 | 19 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| 2107 | 361 | 18 | 3H-GR-113808 | -208 | 19 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| CHEMBL275854 | 361 | 18 | 3H-GR-113808 | -208 | 19 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| 57174031 | 214153 | 0 | 3H-5HT | -33 | 20 | Rat | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | -2 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| None | 214227 | 0 | 3H-GR-113808 | 1 | 6 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 258 | 3498 | 25 | 3H-5HT | -2 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 258 | 3498 | 25 | 3H-GR-113808 | -2 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-5HT | -2 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-GR-113808 | -2 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-5HT | -2 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-GR-113808 | -2 | 8 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 5 | 139 | 66 | 3H-RS 57639 | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-RS 57639 | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-RS 57639 | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-RS 57639 | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -14 | 20 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -6 | 20 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 258 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 130 | 3431 | 43 | 35S-GTPGammaS | -562 | 13 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | ||
| 3378093 | 3431 | 43 | 35S-GTPGammaS | -562 | 13 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | ||
| CHEMBL281350 | 3431 | 43 | 35S-GTPGammaS | -562 | 13 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | ||
| None | 214227 | 0 | 3H-GR-113808 | -2 | 6 | Rat | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| None | 214227 | 0 | 3H-ZACOPRIDE | -2 | 6 | Rat | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| None | 214185 | 0 | 3H-GR-113808 | 4 | 2 | Mouse | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 336 | 1 | 2 | 4 | 1.9 | CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -457 | 31 | Mouse | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -457 | 31 | Mouse | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -457 | 31 | Mouse | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | 1 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 240 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-5HT | -8 | 25 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 258 | 3498 | 25 | 3H-RS 57639 | -2 | 8 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-RS 57639 | -2 | 8 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-RS 57639 | -2 | 8 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 3035240 | 214190 | 0 | 3H-5HT | 1 | 5 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| None | 214227 | 0 | 3H-GR-113808 | -1 | 6 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -33 | 20 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | -2 | 5 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | 1 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 3035240 | 214190 | 0 | 3H-RS 57639 | 1 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| None | 214227 | 0 | 3H-GR-113808 | -1 | 6 | Mouse | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 152 | 361 | 18 | 3H-5HT | -89 | 19 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| 2107 | 361 | 18 | 3H-5HT | -89 | 19 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| CHEMBL275854 | 361 | 18 | 3H-5HT | -89 | 19 | Rat | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | ||
| 3035240 | 214190 | 0 | 3H-5HT | 1 | 5 | Rat | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 1267 | 3732 | 43 | 3H-GR-113808 | -1174 | 28 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| 3035905 | 3732 | 43 | 3H-GR-113808 | -1174 | 28 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| CHEMBL260374 | 3732 | 43 | 3H-GR-113808 | -1174 | 28 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 292 | 2 | 2 | 2 | 2.8 | S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1 | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -2 | 17 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -2 | 17 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -2 | 17 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 240 | 929 | 39 | 3H-GR113808 | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR113808 | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR113808 | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR113808 | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR113808 | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR113808 | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR113808 | -11 | 25 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 119376 | 1803 | 41 | 3H-5HT | -2 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-5HT | -2 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-5HT | -2 | 27 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 119376 | 1803 | 41 | 3H-RS 57639 | -2 | 27 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-RS 57639 | -2 | 27 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-RS 57639 | -2 | 27 | Rat | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | 1 | 17 | Mouse | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 107 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 108182 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 107 | 141 | 116 | 3H-RS 57639 | -257 | 31 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-RS 57639 | -257 | 31 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-RS 57639 | -257 | 31 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 108182 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-5HT | -1 | 17 | Rat | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 1809 | 134 | 28 | 3H-5HT | -46773 | 37 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-5HT | -46773 | 37 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-5HT | -46773 | 37 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -117 | 55 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 107 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-5HT | -257 | 31 | Rat | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1782 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 235 | 2517 | 36 | 3H-GR-113808 | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | None | ||
| 5311299 | 2517 | 36 | 3H-GR-113808 | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | None | ||
| CHEMBL286136 | 2517 | 36 | 3H-GR-113808 | -4 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | None | ||
| None | 214227 | 0 | 3H-GR-113808 | -2 | 6 | Rat | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 441383 | 20118 | 54 | None | -5 | 17 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | None | ||
| CHEMBL1306 | 20118 | 54 | None | -5 | 17 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 531 | 8 | 0 | 8 | 4.5 | CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | None | ||
| 3397 | 203767 | 104 | None | 1 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 276 | 3 | 1 | 3 | 3.2 | CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 | None | ||
| CHEMBL806 | 203767 | 104 | None | 1 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 276 | 3 | 1 | 3 | 3.2 | CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 | None | ||
| 31703 | 193040 | 59 | None | 1 | 3 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | None | ||
| CHEMBL359744 | 193040 | 59 | None | 1 | 3 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | None | ||
| CHEMBL53463 | 193040 | 59 | None | 1 | 3 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | None | ||
| 151537 | 162102 | 43 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | None | ||
| 41867 | 162102 | 43 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | None | ||
| CHEMBL417 | 162102 | 43 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 543 | 5 | 6 | 12 | 0.0 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | None | ||
| 5991 | 202212 | 68 | None | 2 | 5 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 296 | 0 | 2 | 2 | 3.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C | None | ||
| CHEMBL691 | 202212 | 68 | None | 2 | 5 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 296 | 0 | 2 | 2 | 3.6 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C | None | ||
| 4595 | 176131 | 102 | None | -3 | 15 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | ||
| CHEMBL46 | 176131 | 102 | None | -3 | 15 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 293 | 2 | 0 | 4 | 3.1 | Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -389 | 31 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -257 | 31 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1782 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -33 | 20 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 57174031 | 214153 | 0 | 3H-RS 57639 | -33 | 20 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 1809 | 134 | 28 | 3H-RS 57639 | -46773 | 37 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-RS 57639 | -46773 | 37 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-RS 57639 | -46773 | 37 | Rat | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| None | 214451 | 0 | UNDEFINED | -467 | 15 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 438 | 5 | 1 | 4 | 4.8 | C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45 | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -5 | 25 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -457 | 31 | Mouse | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -457 | 31 | Mouse | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -457 | 31 | Mouse | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 2780 | 110027 | 32 | 3H-GR-113808 | -41 | 11 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
| CHEMBL325109 | 110027 | 32 | 3H-GR-113808 | -41 | 11 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
| None | 214492 | 0 | 3H-GR-113808 | -436 | 21 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 416 | 9 | 3 | 4 | 2.8 | C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I | None | ||
| None | 214227 | 0 | 3H-GR-113808 | -1 | 6 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 57174031 | 214153 | 0 | 3H-Cyclic AMP | -14 | 20 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -33 | 20 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -288 | 55 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 1782 | 2472 | 81 | None | -25 | 23 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | None | -25 | 23 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | None | -25 | 23 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | None | -25 | 23 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | None | -25 | 23 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 1782 | 2472 | 81 | None | -11 | 23 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | None | -11 | 23 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | None | -11 | 23 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | None | -11 | 23 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | None | -11 | 23 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 107715 | 199250 | 18 | None | -165 | 20 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | None | ||
| CHEMBL1255837 | 199250 | 18 | None | -165 | 20 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | None | ||
| CHEMBL601773 | 199250 | 18 | None | -165 | 20 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 611 | 5 | 3 | 6 | 2.7 | CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O | None | ||
| 3168 | 9157 | 84 | None | -93 | 22 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
| CHEMBL1108 | 9157 | 84 | None | -93 | 22 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 379 | 6 | 1 | 4 | 3.7 | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 | None | ||
| 1782 | 2472 | 81 | None | -12 | 23 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | None | -12 | 23 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | None | -12 | 23 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | None | -12 | 23 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | None | -12 | 23 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 258 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 258 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 258 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 133 | 2450 | 48 | None | -79 | 43 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| 1723 | 2450 | 48 | None | -79 | 43 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| 28693 | 2450 | 48 | None | -79 | 43 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| CHEMBL19215 | 2450 | 48 | None | -79 | 43 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| DB13520 | 2450 | 48 | None | -79 | 43 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | ||
| 11954224 | 214164 | 0 | None | -93 | 60 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | ||
| 2274 | 3112 | 53 | None | -17 | 32 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 4917 | 3112 | 53 | None | -17 | 32 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 7279 | 3112 | 53 | None | -17 | 32 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| CHEMBL728 | 3112 | 53 | None | -17 | 32 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| DB00433 | 3112 | 53 | None | -17 | 32 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 4 | 0 | 4 | 4.6 | CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | None | ||
| 2585 | 788 | 100 | None | -57 | 22 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | ||
| 522 | 788 | 100 | None | -57 | 22 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | ||
| 551 | 788 | 100 | None | -57 | 22 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | ||
| CHEMBL723 | 788 | 100 | None | -57 | 22 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | ||
| DB01136 | 788 | 100 | None | -57 | 22 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | None | ||
| 10531 | 1387 | 18 | None | -87 | 24 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | ||
| 121 | 1387 | 18 | None | -87 | 24 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | ||
| 888 | 1387 | 18 | None | -87 | 24 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | ||
| CHEMBL1732 | 1387 | 18 | None | -87 | 24 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | ||
| DB00320 | 1387 | 18 | None | -87 | 24 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | ||
| 57174031 | 214153 | 0 | None | -6 | 20 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 57174031 | 214153 | 0 | None | -14 | 20 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 3157 | 1437 | 69 | None | -27 | 12 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | None | ||
| 7170 | 1437 | 69 | None | -27 | 12 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | None | ||
| 954 | 1437 | 69 | None | -27 | 12 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | None | ||
| CHEMBL707 | 1437 | 69 | None | -27 | 12 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | None | ||
| DB00590 | 1437 | 69 | None | -27 | 12 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 451 | 4 | 2 | 8 | 1.5 | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 | None | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| 242 | 2547 | 99 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| 2780 | 110027 | 32 | None | -20 | 11 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
| CHEMBL325109 | 110027 | 32 | None | -20 | 11 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
| 2780 | 110027 | 32 | None | -20 | 11 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
| CHEMBL325109 | 110027 | 32 | None | -20 | 11 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 373 | 5 | 2 | 4 | 3.3 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -4 | 25 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -11 | 25 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -14 | 20 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| None | 214227 | 0 | 3H-GR-113808 | 1 | 6 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| None | 214227 | 0 | 3H-GR-113808 | -2 | 6 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 107 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1833 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| CHEMBL8165 | 141 | 116 | 3H-GR-113808 | -549 | 31 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | ||
| 1782 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | 3H-GR-113808 | -12 | 23 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -87096 | 37 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -87096 | 37 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -87096 | 37 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 57174031 | 214153 | 0 | None | -8 | 20 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| 242 | 2547 | 99 | None | -1 | 6 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | None | ||
| 57174031 | 214153 | 0 | None | -33 | 20 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 240 | 929 | 39 | None | -5 | 25 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | None | -5 | 25 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | None | -5 | 25 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | None | -5 | 25 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | None | -5 | 25 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | None | -5 | 25 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | None | -5 | 25 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 258 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Mouse | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Mouse | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-GR-113808 | -1 | 8 | Mouse | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 240 | 929 | 39 | None | -4 | 25 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | None | -4 | 25 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | None | -4 | 25 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | None | -4 | 25 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | None | -4 | 25 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | None | -4 | 25 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | None | -4 | 25 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 5 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-5HT | -117 | 55 | Rat | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 258 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5191 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL287045 | 3498 | 25 | 3H-GR-113808 | 1 | 8 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 5202 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| CHEMBL39 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -190 | 55 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| DB08839 | 139 | 66 | 3H-GR-113808 | -154 | 55 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | ||
| 240 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | 3H-GR-113808 | -8 | 25 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| None | 214227 | 0 | 3H-5HT | -2 | 6 | Rat | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 367 | 2 | 1 | 6 | 2.4 | CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 108182 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-RS 57639 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 240 | 929 | 39 | None | -8 | 25 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 2769 | 929 | 39 | None | -8 | 25 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 44279790 | 929 | 39 | None | -8 | 25 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 660 | 929 | 39 | None | -8 | 25 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL1729 | 929 | 39 | None | -8 | 25 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| CHEMBL560739 | 929 | 39 | None | -8 | 25 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| DB00604 | 929 | 39 | None | -8 | 25 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | None | ||
| 135526515 | 215990 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 301 | 7 | 4 | 3 | 2.8 | CCCCCNC(=N)NN=CC1=CNC2=C1C=C(OC)C=C2 | None | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 108182 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 245 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| CHEMBL18041 | 4055 | 18 | 3H-GR-113808 | -1 | 17 | Rat | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | ||
| 57174031 | 214153 | 0 | 3H-GR-113808 | -8 | 20 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 1782 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 241 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 4168 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| CHEMBL86 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| DB01233 | 2472 | 81 | 3H-GR-113808 | -25 | 23 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -46773 | 37 | Rat | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 3035240 | 214190 | 0 | 3H-GR-113808 | -1 | 5 | Mouse | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 359 | 3 | 2 | 4 | 2.6 | COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl | None | ||
| 1809 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Mouse | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 4 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Mouse | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| CHEMBL18840 | 134 | 28 | 3H-GR-113808 | -109647 | 37 | Mouse | 5.0 | pKi | = | 5.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | ||
| 57174031 | 214153 | 0 | 3H-ZACOPRIDE | -33 | 20 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | ||
| 53354764 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | ||
| 9059 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | ||
| CHEMBL2152922 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | ||
| DB12675 | 3003 | 30 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 8 | 2.6 | OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1 | 22974325 | ||
| 121881 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10646498 | ||
| 121881 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10683202 | ||
| 121881 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 11030734 | ||
| 121881 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9349523 | ||
| 256 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10646498 | ||
| 256 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10683202 | ||
| 256 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 11030734 | ||
| 256 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9349523 | ||
| CHEMBL68131 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10646498 | ||
| CHEMBL68131 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 10683202 | ||
| CHEMBL68131 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 11030734 | ||
| CHEMBL68131 | 3421 | 21 | None | -2 | 15 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9349523 | ||
| 250 | 3322 | 5 | None | 2 | 13 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 15351779 | ||
| 250 | 3322 | 5 | None | 2 | 13 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 9351641 | ||
| 5311416 | 3322 | 5 | None | 2 | 13 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 15351779 | ||
| 5311416 | 3322 | 5 | None | 2 | 13 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 9351641 | ||
| CHEMBL69733 | 3322 | 5 | None | 2 | 13 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 15351779 | ||
| CHEMBL69733 | 3322 | 5 | None | 2 | 13 | Human | 10.5 | pKi | = | 10.5 | Binding | Guide to Pharmacology | 502 | 10 | 1 | 7 | 5.0 | COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC | 9351641 | ||
| 1782 | 2472 | 81 | None | -25 | 23 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | ||
| 241 | 2472 | 81 | None | -25 | 23 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | ||
| 4168 | 2472 | 81 | None | -25 | 23 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | ||
| CHEMBL86 | 2472 | 81 | None | -25 | 23 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | ||
| DB01233 | 2472 | 81 | None | -25 | 23 | Mouse | 6.0 | pKi | = | 6 | Binding | Guide to Pharmacology | 299 | 7 | 2 | 4 | 2.0 | CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC | 8946946 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | ||
| 240 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | ||
| 2769 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | ||
| 44279790 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | ||
| 660 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | ||
| CHEMBL1729 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | ||
| CHEMBL560739 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10646498 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 11218067 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 7796807 | ||
| DB00604 | 929 | 39 | None | -11 | 25 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9349523 | ||
| 234 | 654 | 0 | None | -1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9351641 | ||
| 5311029 | 654 | 0 | None | -1 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9351641 | ||
| 11842633 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 18415081 | ||
| 11842633 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 22959244 | ||
| 8425 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 18415081 | ||
| 8425 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 22959244 | ||
| CHEMBL2087337 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 18415081 | ||
| CHEMBL2087337 | 3906 | 17 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 504 | 8 | 2 | 7 | 1.6 | O[C@@H](CN(S(=O)(=O)C)C)CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)c1cc2ccccc2n(c1=O)C(C)C | 22959244 | ||
| 10584 | 1430 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 25157130 | ||
| 86582973 | 1430 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 25157130 | ||
| CHEMBL3417009 | 1430 | 0 | None | 1 | 2 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 392 | 7 | 1 | 4 | 5.2 | COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl | 25157130 | ||
| 45275554 | 3248 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | ||
| 8427 | 3248 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | ||
| CHEMBL3544975 | 3248 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | ||
| DB12798 | 3248 | 0 | None | 6 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 492 | 9 | 3 | 6 | 3.7 | COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl | 25316608 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10683202 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10821780 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 11030734 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 12801225 | ||
| 235 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 9603189 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10683202 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10821780 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 11030734 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 12801225 | ||
| 5311299 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 9603189 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10683202 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 10821780 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 11030734 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 12801225 | ||
| CHEMBL286136 | 2517 | 36 | None | -4 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | 312 | 5 | 1 | 5 | 2.6 | COc1cc(N)c(cc1C(=O)OCCN1CCCCC1)Cl | 9603189 | ||
| 11961293 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | ||
| 8426 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | ||
| CHEMBL2402904 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | ||
| DB12725 | 3698 | 13 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 455 | 6 | 2 | 5 | 3.6 | COC(=O)N1CCC(CC1)CN1CCC(CC1)CNC(=O)c1cccc2c1nc([nH]2)C(C)C | 23756062 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10646498 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11030734 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11218067 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 15351779 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9349523 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9351641 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9603189 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10646498 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11030734 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11218067 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 15351779 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9349523 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9351641 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9603189 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 10646498 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11030734 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 11218067 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 15351779 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9349523 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9351641 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9603189 | ||
| 257 | 3424 | 9 | None | -1 | 4 | Human | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 11218067 | ||
| 5311423 | 3424 | 9 | None | -1 | 4 | Human | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 11218067 | ||
| CHEMBL114112 | 3424 | 9 | None | -1 | 4 | Human | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | 474 | 6 | 1 | 6 | 3.3 | CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N | 11218067 | ||
| 248 | 1804 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9349523 | ||
| 248 | 1804 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9351641 | ||
| 4284721 | 1804 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9349523 | ||
| 4284721 | 1804 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9351641 | ||
| CHEMBL471233 | 1804 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9349523 | ||
| CHEMBL471233 | 1804 | 0 | None | -2 | 2 | Human | 10.3 | pKi | None | 10.3 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 9351641 | ||
| 248 | 1804 | 0 | None | 2 | 2 | Mouse | 10.6 | pKi | None | 10.6 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 8946946 | ||
| 4284721 | 1804 | 0 | None | 2 | 2 | Mouse | 10.6 | pKi | None | 10.6 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 8946946 | ||
| CHEMBL471233 | 1804 | 0 | None | 2 | 2 | Mouse | 10.6 | pKi | None | 10.6 | Binding | Guide to Pharmacology | 427 | 8 | 2 | 6 | 1.7 | COc1[nH]c2c(c1C(=O)OCC1CCN(CC1)CCNS(=O)(=O)C)cc(cc2)F | 8946946 | ||
| 108182 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 7796807 | ||
| 108182 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9351641 | ||
| 108182 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9603189 | ||
| 245 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 7796807 | ||
| 245 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9351641 | ||
| 245 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9603189 | ||
| CHEMBL18041 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 7796807 | ||
| CHEMBL18041 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9351641 | ||
| CHEMBL18041 | 4055 | 18 | None | -2 | 17 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9603189 | ||
| 152 | 361 | 18 | None | -208 | 19 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 15466450 | ||
| 152 | 361 | 18 | None | -208 | 19 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 7796807 | ||
| 2107 | 361 | 18 | None | -208 | 19 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 15466450 | ||
| 2107 | 361 | 18 | None | -208 | 19 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 7796807 | ||
| CHEMBL275854 | 361 | 18 | None | -208 | 19 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 15466450 | ||
| CHEMBL275854 | 361 | 18 | None | -208 | 19 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 7796807 | ||
| 152 | 361 | 18 | None | -89 | 19 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8813606 | ||
| 152 | 361 | 18 | None | -89 | 19 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 9225293 | ||
| 2107 | 361 | 18 | None | -89 | 19 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8813606 | ||
| 2107 | 361 | 18 | None | -89 | 19 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 9225293 | ||
| CHEMBL275854 | 361 | 18 | None | -89 | 19 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8813606 | ||
| CHEMBL275854 | 361 | 18 | None | -89 | 19 | Rat | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 9225293 | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10646498 | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10683202 | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11030734 | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11218067 | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9349523 | ||
| 107 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9603189 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10646498 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10683202 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11030734 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11218067 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9349523 | ||
| 1833 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9603189 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10646498 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 10683202 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11030734 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 11218067 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9349523 | ||
| CHEMBL8165 | 141 | 116 | None | -389 | 31 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9603189 | ||
| 244 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 10683202 | ||
| 244 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11030734 | ||
| 244 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11218067 | ||
| 244 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 7796807 | ||
| 244 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9351641 | ||
| 244 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9603189 | ||
| 3086547 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 10683202 | ||
| 3086547 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11030734 | ||
| 3086547 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 11218067 | ||
| 3086547 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 7796807 | ||
| 3086547 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9351641 | ||
| 3086547 | 3250 | 0 | None | -5 | 3 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9603189 | ||
| 108182 | 4055 | 18 | None | -1 | 17 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8813606 | ||
| 108182 | 4055 | 18 | None | -1 | 17 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9225293 | ||
| 245 | 4055 | 18 | None | -1 | 17 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8813606 | ||
| 245 | 4055 | 18 | None | -1 | 17 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9225293 | ||
| CHEMBL18041 | 4055 | 18 | None | -1 | 17 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8813606 | ||
| CHEMBL18041 | 4055 | 18 | None | -1 | 17 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 9225293 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | ||
| 5 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | ||
| 5202 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | ||
| CHEMBL39 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10646498 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10683202 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10821780 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11030734 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 11218067 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15351779 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15466450 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9349523 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9351641 | ||
| DB08839 | 139 | 66 | None | -288 | 55 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9603189 | ||
| 119584 | 2547 | 99 | None | -1 | 6 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | ||
| 1848 | 2547 | 99 | None | -1 | 6 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | ||
| 242 | 2547 | 99 | None | -1 | 6 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | ||
| CHEMBL60889 | 2547 | 99 | None | -1 | 6 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | ||
| DB11675 | 2547 | 99 | None | -1 | 6 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 421 | 7 | 2 | 5 | 3.1 | CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl | 10646498 | ||
| 107 | 141 | 116 | None | -457 | 31 | Mouse | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8946946 | ||
| 1833 | 141 | 116 | None | -457 | 31 | Mouse | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8946946 | ||
| CHEMBL8165 | 141 | 116 | None | -457 | 31 | Mouse | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8946946 | ||
| 260 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | ||
| 260 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | ||
| 2775 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | ||
| 2775 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | ||
| 656665 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | ||
| 656665 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | ||
| CHEMBL56564 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | ||
| CHEMBL56564 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | ||
| DB11699 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 11218067 | ||
| DB11699 | 3796 | 49 | None | -38 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 9349523 | ||
| 108182 | 4055 | 18 | None | 1 | 17 | Mouse | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8946946 | ||
| 245 | 4055 | 18 | None | 1 | 17 | Mouse | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8946946 | ||
| CHEMBL18041 | 4055 | 18 | None | 1 | 17 | Mouse | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | 8946946 | ||
| 260 | 3796 | 49 | None | -19 | 6 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | ||
| 2775 | 3796 | 49 | None | -19 | 6 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | ||
| 656665 | 3796 | 49 | None | -19 | 6 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | ||
| CHEMBL56564 | 3796 | 49 | None | -19 | 6 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | ||
| DB11699 | 3796 | 49 | None | -19 | 6 | Rat | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8813606 | ||
| 107 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 7796807 | ||
| 107 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8813606 | ||
| 107 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9225293 | ||
| 1833 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 7796807 | ||
| 1833 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8813606 | ||
| 1833 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9225293 | ||
| CHEMBL8165 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 7796807 | ||
| CHEMBL8165 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8813606 | ||
| CHEMBL8165 | 141 | 116 | None | -257 | 31 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 9225293 | ||
| 244 | 3250 | 0 | None | -1 | 3 | Mouse | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8946946 | ||
| 3086547 | 3250 | 0 | None | -1 | 3 | Mouse | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8946946 | ||
| 244 | 3250 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8813606 | ||
| 244 | 3250 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9225293 | ||
| 3086547 | 3250 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 8813606 | ||
| 3086547 | 3250 | 0 | None | 1 | 3 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 323 | 3 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)N[C@H]1CCN2C[C@@H]1CCC2)Cl | 9225293 | ||
| 260 | 3796 | 49 | None | -15 | 6 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | ||
| 2775 | 3796 | 49 | None | -15 | 6 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | ||
| 656665 | 3796 | 49 | None | -15 | 6 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | ||
| CHEMBL56564 | 3796 | 49 | None | -15 | 6 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | ||
| DB11699 | 3796 | 49 | None | -15 | 6 | Mouse | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 284 | 2 | 1 | 3 | 3.0 | CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 | 8946946 | ||
| 5 | 139 | 66 | None | -154 | 55 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | ||
| 5202 | 139 | 66 | None | -154 | 55 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | ||
| CHEMBL39 | 139 | 66 | None | -154 | 55 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | ||
| DB08839 | 139 | 66 | None | -154 | 55 | Mouse | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8946946 | ||
| 129928 | 1297 | 0 | None | -5 | 2 | Mouse | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 8946946 | ||
| 246 | 1297 | 0 | None | -5 | 2 | Mouse | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 8946946 | ||
| CHEMBL1194556 | 1297 | 0 | None | -5 | 2 | Mouse | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 8946946 | ||
| 233 | 653 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 10683202 | ||
| 233 | 653 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 11030734 | ||
| 233 | 653 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 9603189 | ||
| 9929033 | 653 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 10683202 | ||
| 9929033 | 653 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 11030734 | ||
| 9929033 | 653 | 0 | None | -1 | 2 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 9603189 | ||
| 240 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | ||
| 240 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | ||
| 2769 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | ||
| 2769 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | ||
| 44279790 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | ||
| 44279790 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | ||
| 660 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | ||
| 660 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | ||
| CHEMBL1729 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | ||
| CHEMBL1729 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | ||
| CHEMBL560739 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | ||
| CHEMBL560739 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | ||
| DB00604 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8813606 | ||
| DB00604 | 929 | 39 | None | -8 | 25 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 9225293 | ||
| 234 | 654 | 0 | None | -1 | 3 | Mouse | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 8946946 | ||
| 5311029 | 654 | 0 | None | -1 | 3 | Mouse | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 8946946 | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| 5 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| 5202 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| CHEMBL39 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 7796807 | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8813606 | ||
| DB08839 | 139 | 66 | None | -117 | 55 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225293 | ||
| 234 | 654 | 0 | None | 1 | 3 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9225293 | ||
| 5311029 | 654 | 0 | None | 1 | 3 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 342 | 2 | 1 | 5 | 2.6 | CN1[C@@H]2CC[C@H]1CC(C2)NC(=O)n1c(=O)n(c2c1cccc2)C(C)C | 9225293 | ||
| 233 | 653 | 0 | None | 1 | 2 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 8946946 | ||
| 9929033 | 653 | 0 | None | 1 | 2 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 328 | 2 | 1 | 5 | 2.0 | CCn1c(=O)n(c2c1cccc2)C(=O)NC1CC2CC[C@@H](C1)N2C | 8946946 | ||
| 240 | 929 | 39 | None | -5 | 25 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | ||
| 2769 | 929 | 39 | None | -5 | 25 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | ||
| 44279790 | 929 | 39 | None | -5 | 25 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | ||
| 660 | 929 | 39 | None | -5 | 25 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | ||
| CHEMBL1729 | 929 | 39 | None | -5 | 25 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | ||
| CHEMBL560739 | 929 | 39 | None | -5 | 25 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | ||
| DB00604 | 929 | 39 | None | -5 | 25 | Mouse | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 465 | 9 | 2 | 6 | 3.4 | COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N | 8946946 | ||
| 258 | 3498 | 25 | None | -2 | 8 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 9225293 | ||
| 5191 | 3498 | 25 | None | -2 | 8 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 9225293 | ||
| CHEMBL287045 | 3498 | 25 | None | -2 | 8 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 9225293 | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | ||
| 243 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | ||
| 3052762 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | ||
| 3502 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | ||
| CHEMBL117287 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 10646498 | ||
| DB06480 | 3141 | 85 | None | 12 | 34 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | 11438309 | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10646498 | ||
| 135409453 | 3702 | 38 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 15466450 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10646498 | ||
| 226 | 3702 | 38 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 15466450 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10646498 | ||
| CHEMBL76370 | 3702 | 38 | None | -2 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 15466450 | ||
| 129928 | 1297 | 0 | None | 5 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 9351641 | ||
| 246 | 1297 | 0 | None | 5 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 9351641 | ||
| CHEMBL1194556 | 1297 | 0 | None | 5 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 331 | 2 | 1 | 6 | 1.9 | COc1ccc2c(c1)n(C(=O)OC1CC3CCC(C1)N3C)c(=O)[nH]2 | 9351641 | ||
| 132337 | 3474 | 8 | None | 1 | 2 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 8946946 | ||
| 238 | 3474 | 8 | None | 1 | 2 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 8946946 | ||
| CHEMBL34291 | 3474 | 8 | None | 1 | 2 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 323 | 4 | 2 | 4 | 2.1 | COc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl | 8946946 | ||
| 258 | 3498 | 25 | None | -1 | 8 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 7498967 | ||
| 5191 | 3498 | 25 | None | -1 | 8 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 7498967 | ||
| CHEMBL287045 | 3498 | 25 | None | -1 | 8 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 300 | 7 | 1 | 5 | 2.4 | CCN(CCOC(=O)c1cc(Cl)c(cc1OC)N)CC | 7498967 | ||
| 182593 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10683202 | ||
| 182593 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 11030734 | ||
| 182593 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 15351779 | ||
| 254 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10683202 | ||
| 254 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 11030734 | ||
| 254 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 15351779 | ||
| CHEMBL83954 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 10683202 | ||
| CHEMBL83954 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 11030734 | ||
| CHEMBL83954 | 3331 | 4 | None | 1 | 3 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 326 | 6 | 1 | 5 | 3.0 | COc1cc(N)c(cc1C(=O)OCCCN1CCCCC1)Cl | 15351779 | ||
| 183782 | 3334 | 15 | None | -1 | 15 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| 183782 | 3334 | 15 | None | -1 | 15 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| 237 | 3334 | 15 | None | -1 | 15 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| 237 | 3334 | 15 | None | -1 | 15 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| CHEMBL85251 | 3334 | 15 | None | -1 | 15 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 10683202 | ||
| CHEMBL85251 | 3334 | 15 | None | -1 | 15 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 352 | 8 | 1 | 4 | 4.4 | CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N | 11030734 | ||
| 119376 | 1803 | 41 | None | -2 | 27 | Rat | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9225293 | ||
| 247 | 1803 | 41 | None | -2 | 27 | Rat | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9225293 | ||
| CHEMBL33884 | 1803 | 41 | None | -2 | 27 | Rat | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 9225293 | ||
| 236 | 3333 | 0 | None | -4 | 2 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 239 | 3333 | 0 | None | -4 | 2 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 5311417 | 3333 | 0 | None | -4 | 2 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| CHEMBL1908857 | 3333 | 0 | None | -4 | 2 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 474 | 8 | 1 | 7 | 4.2 | COc1cc(N)c(cc1C(=O)OCC1CCN(CC1)CCCc1ccc2c(c1)OCCO2)Cl | 9225293 | ||
| 255 | 3420 | 13 | None | -1 | 2 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 11218067 | ||
| 3272300 | 3420 | 13 | None | -1 | 2 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 11218067 | ||
| CHEMBL1255781 | 3420 | 13 | None | -1 | 2 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 272 | 4 | 1 | 3 | 2.8 | O=C(c1c[nH]c2c1cccc2)OCCN1CCCCC1 | 11218067 | ||
| 121881 | 3421 | 21 | None | -27 | 15 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9225293 | ||
| 256 | 3421 | 21 | None | -27 | 15 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9225293 | ||
| CHEMBL68131 | 3421 | 21 | None | -27 | 15 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | 9225293 | ||
| 29 | 778 | 0 | None | 1584 | 9 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | ||
| 9805719 | 778 | 0 | None | 1584 | 9 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | ||
| CHEMBL2027925 | 778 | 0 | None | 1584 | 9 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 456 | 5 | 1 | 8 | 3.4 | Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1 | 12130738 | ||
| 252 | 3278 | 1 | None | 1 | 2 | Mouse | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 11976337 | ||
| 44391713 | 3278 | 1 | None | 1 | 2 | Mouse | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 11976337 | ||
| CHEMBL182590 | 3278 | 1 | None | 1 | 2 | Mouse | 9.3 | pKi | None | 9.3 | Binding | Guide to Pharmacology | 332 | 6 | 1 | 4 | 2.7 | CCCCN1CCC(CC1)CNC(=O)c1cccc2c1OCCO2 | 11976337 | ||
| 249 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10683202 | ||
| 249 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10821780 | ||
| 249 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 11030734 | ||
| 249 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 15466450 | ||
| 249 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 9603189 | ||
| 9905972 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10683202 | ||
| 9905972 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10821780 | ||
| 9905972 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 11030734 | ||
| 9905972 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 15466450 | ||
| 9905972 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 9603189 | ||
| CHEMBL155917 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10683202 | ||
| CHEMBL155917 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 10821780 | ||
| CHEMBL155917 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 11030734 | ||
| CHEMBL155917 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 15466450 | ||
| CHEMBL155917 | 2518 | 3 | None | 1 | 2 | Human | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 5 | 3.1 | COc1cc(N)c(cc1C(=O)OCCN1CC(C)CC(C1)C)Cl | 9603189 | ||
| 10404587 | 3326 | 3 | None | - | 1 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 11976337 | ||
| 251 | 3326 | 3 | None | - | 1 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 11976337 | ||
| CHEMBL130040 | 3326 | 3 | None | - | 1 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 333 | 6 | 0 | 5 | 3.1 | CCCCN1CCC(CC1)COC(=O)c1cccc2c1OCCO2 | 11976337 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | ||
| 177336 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | ||
| 225 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | ||
| CHEMBL356359 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 11504648 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 15466450 | ||
| DB04873 | 3059 | 45 | None | 6 | 3 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 369 | 6 | 1 | 4 | 3.7 | CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2 | 9351641 | ||
| 119376 | 1803 | 41 | None | -1 | 27 | Mouse | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 8946946 | ||
| 247 | 1803 | 41 | None | -1 | 27 | Mouse | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 8946946 | ||
| CHEMBL33884 | 1803 | 41 | None | -1 | 27 | Mouse | 9.7 | pKi | None | 9.7 | Binding | Guide to Pharmacology | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | 8946946 | ||