Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 122227 | 1346 | 27 | None | -97 | 3 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10042-7 | ||||
| 3825 | 1346 | 27 | None | -97 | 3 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10042-7 | ||||
| 644 | 1346 | 27 | None | -97 | 3 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10042-7 | ||||
| CHEMBL264100 | 1346 | 27 | None | -97 | 3 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)10042-7 | ||||
| 44323260 | 106519 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 845 | 32 | 10 | 10 | 0.7 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| CHEMBL315388 | 106519 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 845 | 32 | 10 | 10 | 0.7 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| 11757682 | 121513 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL359553 | 121513 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11214480 | 148635 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 514 | 7 | 4 | 5 | 4.3 | O=C(Nc1[nH]nc(C(=O)Nc2ccc(CCC3=NCCN3)cc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL394370 | 148635 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 514 | 7 | 4 | 5 | 4.3 | O=C(Nc1[nH]nc(C(=O)Nc2ccc(CCC3=NCCN3)cc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 57397292 | 69701 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 522 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939758 | 69701 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 522 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 54772237 | 65437 | 0 | None | 6 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 525 | 5 | 1 | 6 | 5.0 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834752 | 65437 | 0 | None | 6 | 2 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 525 | 5 | 1 | 6 | 5.0 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| 60142570 | 125381 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 | nan | ||
| CHEMBL3648475 | 125381 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 | nan | ||
| 60142706 | 125386 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 551 | 7 | 2 | 8 | 4.6 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| CHEMBL3648480 | 125386 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 551 | 7 | 2 | 8 | 4.6 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| 11570120 | 69698 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 536 | 7 | 2 | 5 | 3.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939755 | 69698 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 536 | 7 | 2 | 5 | 3.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 24970287 | 187829 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 574 | 7 | 2 | 6 | 4.2 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL502140 | 187829 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 574 | 7 | 2 | 6 | 4.2 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 46230121 | 200449 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 546 | 7 | 2 | 9 | 3.3 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL609157 | 200449 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 546 | 7 | 2 | 9 | 3.3 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 46230161 | 199725 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 561 | 7 | 2 | 10 | 3.3 | CCN(NC(=O)c1cc(OC)no1)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL604735 | 199725 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 561 | 7 | 2 | 10 | 3.3 | CCN(NC(=O)c1cc(OC)no1)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 54582655 | 61852 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 552 | 7 | 2 | 5 | 3.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777969 | 61852 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 552 | 7 | 2 | 5 | 3.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587189 | 171865 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 588 | 7 | 2 | 6 | 4.5 | Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL447870 | 171865 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 588 | 7 | 2 | 6 | 4.5 | Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.055 | ||
| 56594769 | 65380 | 0 | None | 6 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834619 | 65380 | 0 | None | 6 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 665 | 957 | 2 | None | 1 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2008.07.055 | ||
| 9916412 | 957 | 2 | None | 1 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL189123 | 957 | 2 | None | 1 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2008.07.055 | ||
| 665 | 957 | 2 | None | 1 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 9916412 | 957 | 2 | None | 1 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| CHEMBL189123 | 957 | 2 | None | 1 | 4 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 46216675 | 198915 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 513 | 5 | 2 | 7 | 4.3 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCC(F)(F)CC3)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL599285 | 198915 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 513 | 5 | 2 | 7 | 4.3 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCC(F)(F)CC3)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| 46230160 | 198887 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 547 | 7 | 2 | 10 | 2.7 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL599153 | 198887 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 547 | 7 | 2 | 10 | 2.7 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 11387387 | 61850 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777967 | 61850 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 57523216 | 125382 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 562 | 7 | 2 | 8 | 4.4 | COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| CHEMBL3648476 | 125382 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 562 | 7 | 2 | 8 | 4.4 | COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| 60142962 | 125394 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 552 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 | nan | ||
| CHEMBL3648488 | 125394 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 552 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 | nan | ||
| 60142963 | 125395 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648489 | 125395 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 60143095 | 125396 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 563 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 | nan | ||
| CHEMBL3648490 | 125396 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 563 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 | nan | ||
| 60141038 | 125400 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 564 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| CHEMBL3648494 | 125400 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 564 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| 60141185 | 125408 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 563 | 7 | 2 | 10 | 2.6 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 | nan | ||
| CHEMBL3648502 | 125408 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 563 | 7 | 2 | 10 | 2.6 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 | nan | ||
| 60141464 | 125414 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 550 | 6 | 2 | 9 | 3.4 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 | nan | ||
| CHEMBL3648508 | 125414 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 550 | 6 | 2 | 9 | 3.4 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 | nan | ||
| 60141466 | 125416 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 569 | 7 | 2 | 10 | 3.6 | COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 | nan | ||
| CHEMBL3648510 | 125416 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 569 | 7 | 2 | 10 | 3.6 | COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 | nan | ||
| 57398978 | 69700 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 496 | 7 | 2 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939757 | 69700 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 496 | 7 | 2 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 53248885 | 61841 | 0 | None | 18 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777958 | 61841 | 0 | None | 18 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 53248885 | 61841 | 0 | None | 18 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1777958 | 61841 | 0 | None | 18 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57396447 | 69746 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 488 | 5 | 2 | 5 | 2.2 | CN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C(C)(C)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939944 | 69746 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 488 | 5 | 2 | 5 | 2.2 | CN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C(C)(C)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57400696 | 69702 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 508 | 8 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939759 | 69702 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 508 | 8 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57392941 | 69741 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 488 | 6 | 2 | 5 | 2.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCCC3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939939 | 69741 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 488 | 6 | 2 | 5 | 2.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCCC3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11442712 | 84788 | 0 | None | 9 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL225607 | 84788 | 0 | None | 9 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 46230120 | 197520 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 547 | 7 | 2 | 9 | 3.9 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL589820 | 197520 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 547 | 7 | 2 | 9 | 3.9 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 46230203 | 198955 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 532 | 5 | 2 | 7 | 3.6 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL599574 | 198955 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 532 | 5 | 2 | 7 | 3.6 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 57395448 | 69699 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 468 | 6 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939756 | 69699 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 468 | 6 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57398238 | 69743 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 474 | 5 | 3 | 5 | 1.8 | CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939941 | 69743 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 474 | 5 | 3 | 5 | 1.8 | CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 57391173 | 69745 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 482 | 5 | 2 | 5 | 2.2 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939943 | 69745 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 482 | 5 | 2 | 5 | 2.2 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 46230404 | 198665 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 492 | 6 | 2 | 7 | 5.2 | CC(=O)Nn1c(Cl)cnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL597747 | 198665 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 492 | 6 | 2 | 7 | 5.2 | CC(=O)Nn1c(Cl)cnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| 56589598 | 65436 | 0 | None | 7 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 543 | 5 | 1 | 6 | 5.2 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| CHEMBL1834751 | 65436 | 0 | None | 7 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 543 | 5 | 1 | 6 | 5.2 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| 11214819 | 61833 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777885 | 61833 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 60142704 | 125384 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 521 | 6 | 2 | 7 | 4.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| CHEMBL3648478 | 125384 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 521 | 6 | 2 | 7 | 4.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| 60143096 | 125397 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 522 | 6 | 2 | 8 | 4.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| CHEMBL3648491 | 125397 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 522 | 6 | 2 | 8 | 4.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| 60141324 | 125411 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 552 | 7 | 2 | 10 | 2.8 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| CHEMBL3648505 | 125411 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 552 | 7 | 2 | 10 | 2.8 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| 57401664 | 69744 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 468 | 5 | 3 | 5 | 1.8 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939942 | 69744 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 468 | 5 | 3 | 5 | 1.8 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 11342704 | 61839 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 642 | 7 | 2 | 6 | 4.2 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777956 | 61839 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 642 | 7 | 2 | 6 | 4.2 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54586519 | 61860 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 524 | 9 | 3 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777977 | 61860 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 524 | 9 | 3 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587188 | 192758 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 562 | 7 | 3 | 6 | 4.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL525092 | 192758 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 562 | 7 | 3 | 6 | 4.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.055 | ||
| 54583617 | 61851 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 2.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777968 | 61851 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 2.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 57390218 | 69703 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 538 | 8 | 3 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939760 | 69703 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 538 | 8 | 3 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 16108961 | 908 | 0 | None | 2 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 664 | 908 | 0 | None | 2 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| CHEMBL415848 | 908 | 0 | None | 2 | 3 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 60142703 | 125383 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648477 | 125383 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 60141041 | 125402 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 548 | 6 | 2 | 8 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 | nan | ||
| CHEMBL3648496 | 125402 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 548 | 6 | 2 | 8 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 | nan | ||
| 60141182 | 125405 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 567 | 7 | 2 | 9 | 3.8 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| CHEMBL3648499 | 125405 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 567 | 7 | 2 | 9 | 3.8 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| 71229238 | 125409 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 522 | 6 | 2 | 9 | 2.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| CHEMBL3648503 | 125409 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 522 | 6 | 2 | 9 | 2.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| 60141323 | 125410 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 536 | 6 | 2 | 9 | 3.1 | Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| CHEMBL3648504 | 125410 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 536 | 6 | 2 | 9 | 3.1 | Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| 57392940 | 69733 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 434 | 5 | 2 | 5 | 1.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939931 | 69733 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 434 | 5 | 2 | 5 | 1.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 46230119 | 197519 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 546 | 7 | 2 | 8 | 4.5 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL589819 | 197519 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 546 | 7 | 2 | 8 | 4.5 | CCN(NC(=O)c1cc(OC)no1)C(=O)NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 54581635 | 61834 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 554 | 8 | 2 | 6 | 2.8 | COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777886 | 61834 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 554 | 8 | 2 | 6 | 2.8 | COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 53360054 | 69731 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 420 | 5 | 3 | 5 | 0.9 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939929 | 69731 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 420 | 5 | 3 | 5 | 0.9 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCNCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 16747694 | 87511 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 469 | 6 | 2 | 6 | 5.4 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234097 | 87511 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 469 | 6 | 2 | 6 | 5.4 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 46230163 | 198716 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 532 | 5 | 2 | 6 | 4.7 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL598124 | 198716 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 532 | 5 | 2 | 6 | 4.7 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 11364466 | 61829 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777881 | 61829 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 11341479 | 61861 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 526 | 9 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777978 | 61861 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 526 | 9 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587186 | 172139 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 642 | 7 | 2 | 6 | 5.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL450541 | 172139 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 642 | 7 | 2 | 6 | 5.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 54587514 | 61831 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777883 | 61831 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 46230990 | 198946 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 473 | 7 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(CF)CF)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL599490 | 198946 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 473 | 7 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(CF)CF)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| 60142303 | 125368 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 523 | 5 | 2 | 6 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648462 | 125368 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 523 | 5 | 2 | 6 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60142304 | 125369 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 523 | 5 | 2 | 7 | 3.0 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648463 | 125369 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 523 | 5 | 2 | 7 | 3.0 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 60142437 | 125372 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 540 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648466 | 125372 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 540 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60142440 | 125374 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 536 | 5 | 2 | 6 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648468 | 125374 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 536 | 5 | 2 | 6 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 60142834 | 125389 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 7 | 2 | 8 | 4.5 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 | nan | ||
| CHEMBL3648483 | 125389 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 7 | 2 | 8 | 4.5 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 | nan | ||
| 60142836 | 125391 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 569 | 7 | 2 | 8 | 4.7 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 | nan | ||
| CHEMBL3648485 | 125391 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 569 | 7 | 2 | 8 | 4.7 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 | nan | ||
| 60141465 | 125415 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 539 | 6 | 2 | 9 | 3.6 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| CHEMBL3648509 | 125415 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 539 | 6 | 2 | 9 | 3.6 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| 57398235 | 69735 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 462 | 7 | 2 | 5 | 2.0 | CCCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939933 | 69735 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 462 | 7 | 2 | 5 | 2.0 | CCCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11168954 | 61830 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777882 | 61830 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587187 | 188115 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL504531 | 188115 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587187 | 188115 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL504531 | 188115 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 46216847 | 198746 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 559 | 8 | 2 | 11 | 5.4 | COc1cc(C(=O)Nc2nsnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL598349 | 198746 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 559 | 8 | 2 | 11 | 5.4 | COc1cc(C(=O)Nc2nsnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| 54581667 | 61858 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 538 | 8 | 3 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777975 | 61858 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 538 | 8 | 3 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 60142028 | 125360 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648455 | 125360 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60142438 | 125373 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 536 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648467 | 125373 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 536 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60142835 | 125390 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 550 | 6 | 2 | 7 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648484 | 125390 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 550 | 6 | 2 | 7 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 60142963 | 125395 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648489 | 125395 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 54772237 | 65437 | 0 | None | -6 | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 525 | 5 | 1 | 6 | 5.0 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834752 | 65437 | 0 | None | -6 | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 525 | 5 | 1 | 6 | 5.0 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| 57396446 | 69734 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 448 | 6 | 2 | 5 | 1.6 | CCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939932 | 69734 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 448 | 6 | 2 | 5 | 1.6 | CCN1CC[C@H](NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| 46230202 | 198568 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 548 | 5 | 2 | 7 | 4.1 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL597115 | 198568 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 548 | 5 | 2 | 7 | 4.1 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 54581634 | 61832 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777884 | 61832 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 10239095 | 83487 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 494 | 6 | 2 | 6 | 3.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F | 10.1021/jm061094b | ||
| CHEMBL220657 | 83487 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 494 | 6 | 2 | 6 | 3.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F | 10.1021/jm061094b | ||
| 57398237 | 69742 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 474 | 5 | 3 | 5 | 1.8 | CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939940 | 69742 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 474 | 5 | 3 | 5 | 1.8 | CC1(C)CNCC[C@@H]1NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.11.112 | ||
| 46230309 | 197786 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 591 | 8 | 2 | 10 | 6.0 | COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc3ccccc32)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL591676 | 197786 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 591 | 8 | 2 | 10 | 6.0 | COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc3ccccc32)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| 57398236 | 69740 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 474 | 6 | 2 | 5 | 2.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCC3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939938 | 69740 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 474 | 6 | 2 | 5 | 2.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CCC3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11477390 | 84723 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 | 10.1021/jm049394l | ||
| CHEMBL225218 | 84723 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 | 10.1021/jm049394l | ||
| 46230941 | 199567 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 463 | 5 | 2 | 7 | 3.7 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCC3)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL603907 | 199567 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 463 | 5 | 2 | 7 | 3.7 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCC3)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| 54587552 | 61849 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777966 | 61849 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 16221282 | 85098 | 0 | None | 13 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL227713 | 85098 | 0 | None | 13 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587181 | 188082 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 588 | 7 | 3 | 6 | 4.3 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL503847 | 188082 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 588 | 7 | 3 | 6 | 4.3 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 16221282 | 85098 | 0 | None | 13 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227713 | 85098 | 0 | None | 13 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| 25105469 | 186468 | 6 | None | 2 | 2 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 467 | 8 | 3 | 7 | 2.6 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491198 | 186468 | 6 | None | 2 | 2 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 467 | 8 | 3 | 7 | 2.6 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 60142567 | 125378 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 540 | 5 | 2 | 7 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648472 | 125378 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 540 | 5 | 2 | 7 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 11386138 | 84006 | 0 | None | 8 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL221998 | 84006 | 0 | None | 8 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 44587183 | 172645 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 616 | 8 | 3 | 6 | 5.0 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL452331 | 172645 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 616 | 8 | 3 | 6 | 5.0 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 57403391 | 69736 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 476 | 7 | 2 | 5 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)C)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939934 | 69736 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 476 | 7 | 2 | 5 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)C)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 10217706 | 82798 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 494 | 6 | 2 | 5 | 4.4 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 | 10.1021/jm061094b | ||
| CHEMBL218605 | 82798 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 494 | 6 | 2 | 5 | 4.4 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 | 10.1021/jm061094b | ||
| 11363856 | 84100 | 0 | None | 13 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| CHEMBL222038 | 84100 | 0 | None | 13 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| 11215488 | 61837 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777954 | 61837 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 46230067 | 197797 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 541 | 5 | 2 | 4 | 4.8 | CCN(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL591742 | 197797 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 541 | 5 | 2 | 4 | 4.8 | CCN(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 46230939 | 198588 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 437 | 5 | 2 | 7 | 3.2 | CC(C)N(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL597235 | 198588 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 437 | 5 | 2 | 7 | 3.2 | CC(C)N(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.121 | ||
| 46216846 | 199534 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 543 | 8 | 2 | 11 | 4.9 | COc1cc(C(=O)Nc2nonc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL603668 | 199534 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 543 | 8 | 2 | 11 | 4.9 | COc1cc(C(=O)Nc2nonc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| 56594642 | 65377 | 0 | None | 21 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834616 | 65377 | 0 | None | 21 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 44587182 | 188095 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 602 | 7 | 2 | 6 | 4.6 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL504119 | 188095 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 602 | 7 | 2 | 6 | 4.6 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 57394684 | 69738 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 7 | 2 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(Cc3ccccc3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939936 | 69738 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 7 | 2 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(Cc3ccccc3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 56594772 | 65435 | 0 | None | 15 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 542 | 5 | 1 | 6 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834750 | 65435 | 0 | None | 15 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 542 | 5 | 1 | 6 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 56594769 | 65380 | 0 | None | -6 | 2 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834619 | 65380 | 0 | None | -6 | 2 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 57394685 | 69739 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 460 | 6 | 2 | 5 | 1.7 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CC3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939937 | 69739 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 460 | 6 | 2 | 5 | 1.7 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(C3CC3)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44430696 | 87510 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 484 | 6 | 2 | 4 | 6.1 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234096 | 87510 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 484 | 6 | 2 | 4 | 6.1 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 11225601 | 141483 | 0 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| CHEMBL387638 | 141483 | 0 | None | 3 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| 46230833 | 197573 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 423 | 4 | 2 | 6 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL590150 | 197573 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 423 | 4 | 2 | 6 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| 54580628 | 61827 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777879 | 61827 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 11272685 | 61854 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 1.9 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777971 | 61854 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 1.9 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587041 | 187284 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 574 | 6 | 3 | 6 | 4.0 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL496459 | 187284 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 574 | 6 | 3 | 6 | 4.0 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 54585540 | 61859 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 526 | 7 | 3 | 5 | 3.0 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777976 | 61859 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 526 | 7 | 3 | 5 | 3.0 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 46229967 | 197849 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 537 | 6 | 2 | 3 | 5.1 | C[C@H]1CC[C@@H](C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL592239 | 197849 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 537 | 6 | 2 | 3 | 5.1 | C[C@H]1CC[C@@H](C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 | 10.1016/j.bmcl.2009.11.119 | ||
| 46230162 | 199622 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 548 | 5 | 2 | 6 | 5.2 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL604177 | 199622 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 548 | 5 | 2 | 6 | 5.2 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 46911683 | 15050 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 629 | 10 | 2 | 4 | 6.6 | C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210756 | 15050 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 629 | 10 | 2 | 4 | 6.6 | C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 57403390 | 69723 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 489 | 5 | 2 | 6 | 1.4 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCS(=O)(=O)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939921 | 69723 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 489 | 5 | 2 | 6 | 1.4 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCS(=O)(=O)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57394683 | 69737 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 490 | 6 | 2 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)(C)C)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939935 | 69737 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 490 | 6 | 2 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H]2CCN(CC(C)(C)C)CC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44421279 | 84718 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 442 | 7 | 2 | 6 | 5.2 | COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL225133 | 84718 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 442 | 7 | 2 | 6 | 5.2 | COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 46230940 | 198589 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 451 | 4 | 2 | 7 | 3.6 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(C)(C)C)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL597236 | 198589 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 451 | 4 | 2 | 7 | 3.6 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C(C)(C)C)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| 44587184 | 169576 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 630 | 9 | 3 | 6 | 5.3 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL444431 | 169576 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 630 | 9 | 3 | 6 | 5.3 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 11284304 | 61855 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 553 | 7 | 2 | 6 | 1.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777972 | 61855 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 553 | 7 | 2 | 6 | 1.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 57401663 | 69722 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 455 | 5 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(O)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939920 | 69722 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 455 | 5 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(O)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11167607 | 136808 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL375288 | 136808 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 46216844 | 198977 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 546 | 7 | 2 | 4 | 5.5 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL599779 | 198977 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 546 | 7 | 2 | 4 | 5.5 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 16102897 | 86797 | 13 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL232943 | 86797 | 13 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 17751347 | 69755 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 480 | 4 | 1 | 5 | 1.9 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC3(CCN(C)C3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939953 | 69755 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 480 | 4 | 1 | 5 | 1.9 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC3(CCN(C)C3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 46230403 | 198642 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 458 | 6 | 2 | 7 | 4.5 | CC(=O)Nn1ccnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL597546 | 198642 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 458 | 6 | 2 | 7 | 4.5 | CC(=O)Nn1ccnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| 46230459 | 197531 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 476 | 6 | 2 | 8 | 5.1 | CC(=O)Nc1nsnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL589900 | 197531 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 476 | 6 | 2 | 8 | 5.1 | CC(=O)Nc1nsnc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| 46230352 | 198720 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 541 | 8 | 2 | 10 | 4.8 | COc1cc(C(=O)Nn2ccnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL598147 | 198720 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 541 | 8 | 2 | 10 | 4.8 | COc1cc(C(=O)Nn2ccnc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| 44587185 | 188341 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 630 | 7 | 3 | 6 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL508043 | 188341 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 630 | 7 | 3 | 6 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 11342350 | 61835 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777887 | 61835 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 46216845 | 198979 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 530 | 7 | 2 | 4 | 5.0 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL599780 | 198979 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 530 | 7 | 2 | 4 | 5.0 | CCN(NC(=O)C(F)(F)F)C(=O)N[C@H](C)c1ncc(-c2cc(Cl)cc(F)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 23630715 | 152109 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 550 | 7 | 3 | 5 | 4.0 | CN1CCC(N2CCC(CCNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 | 10.1021/jm051292n | ||
| CHEMBL397248 | 152109 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 550 | 7 | 3 | 5 | 4.0 | CN1CCC(N2CCC(CCNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 | 10.1021/jm051292n | ||
| 10151875 | 136442 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 470 | 6 | 2 | 4 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL374580 | 136442 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 470 | 6 | 2 | 4 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 10031511 | 16750 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| CHEMBL1253497 | 16750 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| 23630813 | 151266 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 560 | 5 | 4 | 5 | 4.1 | O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1F | 10.1021/jm051292n | ||
| CHEMBL396524 | 151266 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 560 | 5 | 4 | 5 | 4.1 | O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1F | 10.1021/jm051292n | ||
| 16221282 | 85098 | 0 | None | -13 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227713 | 85098 | 0 | None | -13 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| 16221111 | 85100 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227721 | 85100 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 11215913 | 136003 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| CHEMBL373654 | 136003 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| 16220918 | 160911 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 585 | 9 | 2 | 6 | 4.7 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL412762 | 160911 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 585 | 9 | 2 | 6 | 4.7 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 | 10.1021/jm070055c | ||
| 44579766 | 192634 | 0 | None | - | 1 | Crab-eating macaque | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 423 | 6 | 1 | 5 | 3.7 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL523773 | 192634 | 0 | None | - | 1 | Crab-eating macaque | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 423 | 6 | 1 | 5 | 3.7 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 49863234 | 15045 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 611 | 12 | 3 | 4 | 6.3 | C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210751 | 15045 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 611 | 12 | 3 | 4 | 6.3 | C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 44561641 | 186132 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL488677 | 186132 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 11635365 | 173979 | 0 | None | -2 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL455642 | 173979 | 0 | None | -2 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 11635365 | 173979 | 0 | None | -2 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1021/jm200808v | ||
| CHEMBL455642 | 173979 | 0 | None | -2 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1021/jm200808v | ||
| 11214998 | 76187 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 551 | 8 | 2 | 4 | 5.3 | CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206247 | 76187 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 551 | 8 | 2 | 4 | 5.3 | CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44428100 | 152998 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 396 | 3 | 2 | 4 | 4.5 | Cc1nc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cs1 | 10.1021/jm051292n | ||
| CHEMBL398008 | 152998 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 396 | 3 | 2 | 4 | 4.5 | Cc1nc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cs1 | 10.1021/jm051292n | ||
| 56594241 | 65531 | 0 | None | 4 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1835756 | 65531 | 0 | None | 4 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 16220987 | 78687 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL2113274 | 78687 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 54587551 | 61844 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777961 | 61844 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44580012 | 186453 | 0 | None | - | 1 | Crab-eating macaque | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 495 | 8 | 1 | 6 | 4.6 | CN(Cc1ccc(-c2nccs2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491041 | 186453 | 0 | None | - | 1 | Crab-eating macaque | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 495 | 8 | 1 | 6 | 4.6 | CN(Cc1ccc(-c2nccs2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 24946441 | 186541 | 0 | None | - | 1 | Crab-eating macaque | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 468 | 6 | 0 | 6 | 2.9 | CN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491829 | 186541 | 0 | None | - | 1 | Crab-eating macaque | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 468 | 6 | 0 | 6 | 2.9 | CN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 60142169 | 125366 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 494 | 5 | 2 | 4 | 4.5 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| CHEMBL3648460 | 125366 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 494 | 5 | 2 | 4 | 4.5 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| 56835163 | 69210 | 0 | None | 1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934264 | 69210 | 0 | None | 1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 23630613 | 91637 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 607 | 8 | 2 | 7 | 5.4 | O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccn1)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL241937 | 91637 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 607 | 8 | 2 | 7 | 5.4 | O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccn1)c1ccccc1Cl | 10.1021/jm051292n | ||
| 11363856 | 84100 | 0 | None | -13 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| CHEMBL222038 | 84100 | 0 | None | -13 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| 23630920 | 92503 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 636 | 9 | 2 | 7 | 6.0 | COc1ccc(-n2nc(C(=O)NCCC3CCN(c4ccncc4)CC3)c(Br)c2NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm051292n | ||
| CHEMBL244093 | 92503 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 636 | 9 | 2 | 7 | 6.0 | COc1ccc(-n2nc(C(=O)NCCC3CCN(c4ccncc4)CC3)c(Br)c2NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm051292n | ||
| 17751599 | 69732 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 420 | 5 | 3 | 5 | 0.9 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCNCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939930 | 69732 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 420 | 5 | 3 | 5 | 0.9 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCNCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57401425 | 69205 | 0 | None | -1 | 2 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934259 | 69205 | 0 | None | -1 | 2 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 25207727 | 197747 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 435 | 6 | 2 | 5 | 2.6 | CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL591354 | 197747 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 435 | 6 | 2 | 5 | 2.6 | CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 | 10.1016/j.bmcl.2009.11.119 | ||
| 16221054 | 141528 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL387982 | 141528 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 | 10.1021/jm070055c | ||
| 11284458 | 140045 | 2 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL381366 | 140045 | 2 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.03.115 | ||
| 11284458 | 140045 | 2 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL381366 | 140045 | 2 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 23631903 | 92343 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 531 | 6 | 4 | 6 | 3.7 | Nc1cccc(N2CCC(CNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)n1 | 10.1021/jm051292n | ||
| CHEMBL243680 | 92343 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 531 | 6 | 4 | 6 | 3.7 | Nc1cccc(N2CCC(CNC(=O)c3n[nH]c(NC(=O)c4ccccc4Cl)c3Br)CC2)n1 | 10.1021/jm051292n | ||
| 11284458 | 140045 | 2 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381366 | 140045 | 2 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44561786 | 172084 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 580 | 9 | 1 | 4 | 7.0 | O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL449789 | 172084 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 580 | 9 | 1 | 4 | 7.0 | O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 17751422 | 69748 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 460 | 5 | 1 | 5 | 1.5 | CN(C)[C@@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939946 | 69748 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 460 | 5 | 1 | 5 | 1.5 | CN(C)[C@@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11420875 | 76969 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 511 | 7 | 2 | 4 | 5.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL208387 | 76969 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 511 | 7 | 2 | 4 | 5.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44579811 | 186274 | 0 | None | - | 1 | Crab-eating macaque | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 502 | 7 | 1 | 6 | 2.8 | CCC(NC(=O)c1nc2ccccc2n1Cc1ccccc1)C(=O)N1CCN(C2CCN(C)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL489588 | 186274 | 0 | None | - | 1 | Crab-eating macaque | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 502 | 7 | 1 | 6 | 2.8 | CCC(NC(=O)c1nc2ccccc2n1Cc1ccccc1)C(=O)N1CCN(C2CCN(C)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 60142707 | 125387 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 544 | 5 | 2 | 6 | 5.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| CHEMBL3648481 | 125387 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 544 | 5 | 2 | 6 | 5.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| 54580655 | 61845 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.8 | Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777962 | 61845 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.8 | Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 57399887 | 69754 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 466 | 4 | 1 | 5 | 1.3 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2C[C@@H]3CN(C)C[C@@H]3C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939952 | 69754 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 466 | 4 | 1 | 5 | 1.3 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2C[C@@H]3CN(C)C[C@@H]3C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 56672397 | 65527 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 432 | 9 | 1 | 3 | 5.6 | O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm200808v | ||
| CHEMBL1835752 | 65527 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 432 | 9 | 1 | 3 | 5.6 | O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm200808v | ||
| 57399671 | 69211 | 0 | None | -2 | 2 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 506 | 5 | 1 | 4 | 6.6 | Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934265 | 69211 | 0 | None | -2 | 2 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 506 | 5 | 1 | 4 | 6.6 | Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 | 10.1016/j.bmcl.2011.10.068 | ||
| 44579943 | 186204 | 0 | None | - | 1 | Crab-eating macaque | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 494 | 8 | 1 | 6 | 3.2 | CN(Cc1ccc(C2=NCCN2C)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL489191 | 186204 | 0 | None | - | 1 | Crab-eating macaque | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 494 | 8 | 1 | 6 | 3.2 | CN(Cc1ccc(C2=NCCN2C)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 16108965 | 160771 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| CHEMBL412552 | 160771 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| 16221057 | 142476 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 607 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL389478 | 142476 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 607 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 16221161 | 143777 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 569 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL390539 | 143777 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 569 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| 44410313 | 75434 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 527 | 8 | 2 | 5 | 4.7 | COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL204847 | 75434 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 527 | 8 | 2 | 5 | 4.7 | COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11685446 | 186112 | 0 | None | -14 | 2 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL488501 | 186112 | 0 | None | -14 | 2 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2008.07.108 | ||
| 56594771 | 65434 | 0 | None | 2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 507 | 5 | 1 | 6 | 4.9 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 | 10.1021/jm200808v | ||
| CHEMBL1834749 | 65434 | 0 | None | 2 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 507 | 5 | 1 | 6 | 4.9 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 | 10.1021/jm200808v | ||
| 46230069 | 199330 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 555 | 5 | 2 | 4 | 5.2 | CC(C)N(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL602320 | 199330 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 555 | 5 | 2 | 4 | 5.2 | CC(C)N(NC(=O)c1cc(F)cc(C(F)(F)F)c1)C(=O)N[C@H](C)c1ncc(C(=O)N2[C@@H](C)CC[C@H]2C)cc1F | 10.1016/j.bmcl.2009.11.119 | ||
| 49863229 | 15040 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210746 | 15040 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 44579828 | 192693 | 0 | None | 1 | 2 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 7 | 0 | 6 | 2.8 | CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL524126 | 192693 | 0 | None | 1 | 2 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 7 | 0 | 6 | 2.8 | CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 57399886 | 69750 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 468 | 5 | 1 | 5 | 1.9 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC(N(C)C)CC2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939948 | 69750 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 468 | 5 | 1 | 5 | 1.9 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC(N(C)C)CC2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 49863231 | 15042 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 10 | 2 | 4 | 5.9 | C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210748 | 15042 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 10 | 2 | 4 | 5.9 | C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 44579795 | 186352 | 0 | None | -30 | 2 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490201 | 186352 | 0 | None | -30 | 2 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 44579828 | 192693 | 0 | None | -1 | 2 | Crab-eating macaque | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 7 | 0 | 6 | 2.8 | CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL524126 | 192693 | 0 | None | -1 | 2 | Crab-eating macaque | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 7 | 0 | 6 | 2.8 | CCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 11317669 | 148795 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 5 | 3 | 4 | 3.2 | C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N1CCCCC1 | 10.1021/jm051292n | ||
| CHEMBL394514 | 148795 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 5 | 3 | 4 | 3.2 | C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N1CCCCC1 | 10.1021/jm051292n | ||
| 11204003 | 76853 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 579 | 7 | 2 | 4 | 6.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL207947 | 76853 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 579 | 7 | 2 | 4 | 6.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2006.01.069 | ||
| 665 | 957 | 2 | None | -89 | 4 | Dog | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 9916412 | 957 | 2 | None | -89 | 4 | Dog | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| CHEMBL189123 | 957 | 2 | None | -89 | 4 | Dog | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 44410328 | 75637 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 537 | 7 | 1 | 4 | 4.9 | CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205501 | 75637 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 537 | 7 | 1 | 4 | 4.9 | CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 23630615 | 92664 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 601 | 10 | 2 | 7 | 4.5 | CN(C)CCn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL244284 | 92664 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 601 | 10 | 2 | 7 | 4.5 | CN(C)CCn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL3038104 | 209182 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 16220917 | 165771 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 543 | 9 | 2 | 5 | 5.0 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL427279 | 165771 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 543 | 9 | 2 | 5 | 5.0 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 16221056 | 85120 | 0 | None | -97 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL227870 | 85120 | 0 | None | -97 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 46230834 | 197574 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 409 | 4 | 2 | 6 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL590151 | 197574 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 409 | 4 | 2 | 6 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| 46230893 | 198678 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 409 | 4 | 2 | 7 | 2.4 | CN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL597840 | 198678 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 409 | 4 | 2 | 7 | 2.4 | CN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.121 | ||
| 57390932 | 69200 | 0 | None | 14 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934254 | 69200 | 0 | None | 14 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 16220916 | 85121 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 571 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227879 | 85121 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 571 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 16108961 | 908 | 0 | None | -10 | 3 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 664 | 908 | 0 | None | -10 | 3 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| CHEMBL415848 | 908 | 0 | None | -10 | 3 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 11526891 | 188281 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL507168 | 188281 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 16221056 | 85120 | 0 | None | 97 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL227870 | 85120 | 0 | None | 97 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 60141326 | 125412 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 444 | 4 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 | nan | ||
| CHEMBL3648506 | 125412 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 444 | 4 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 | nan | ||
| 56594772 | 65435 | 0 | None | -15 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 542 | 5 | 1 | 6 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834750 | 65435 | 0 | None | -15 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 542 | 5 | 1 | 6 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 57396445 | 69727 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 419 | 5 | 2 | 4 | 2.4 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939925 | 69727 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 419 | 5 | 2 | 4 | 2.4 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11213709 | 91877 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 475 | 6 | 4 | 4 | 3.0 | NC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| CHEMBL242994 | 91877 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 475 | 6 | 4 | 4 | 3.0 | NC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| 16108964 | 141177 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL385741 | 141177 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 57398979 | 69707 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 2.5 | COc1ccc2c(c1)C(NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1)CCC2 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939764 | 69707 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 2.5 | COc1ccc2c(c1)C(NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1)CCC2 | 10.1016/j.bmcl.2011.11.112 | ||
| 44579830 | 186400 | 0 | None | 1 | 2 | Crab-eating macaque | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 516 | 8 | 0 | 6 | 3.2 | CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490619 | 186400 | 0 | None | 1 | 2 | Crab-eating macaque | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 516 | 8 | 0 | 6 | 3.2 | CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 57390219 | 69710 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 441 | 5 | 2 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939767 | 69710 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 441 | 5 | 2 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 46230258 | 198745 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 486 | 6 | 2 | 7 | 5.2 | CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc(C)c1C | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL598348 | 198745 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 486 | 6 | 2 | 7 | 5.2 | CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc(C)c1C | 10.1016/j.bmcl.2009.11.120 | ||
| 11512379 | 165441 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 555 | 7 | 2 | 7 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL425416 | 165441 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 555 | 7 | 2 | 7 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 11342079 | 161225 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL414091 | 161225 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 57392728 | 69209 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934263 | 69209 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 44579890 | 186024 | 0 | None | - | 1 | Crab-eating macaque | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 534 | 7 | 1 | 6 | 3.9 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)C1CCN(C(=O)c2nc3ccccc3n2Cc2ccccc2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL487909 | 186024 | 0 | None | - | 1 | Crab-eating macaque | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 534 | 7 | 1 | 6 | 3.9 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)C1CCN(C(=O)c2nc3ccccc3n2Cc2ccccc2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 57403175 | 69204 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934258 | 69204 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 57394686 | 69749 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 480 | 5 | 1 | 5 | 2.0 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CC[C@H](N3CCCC3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939947 | 69749 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 480 | 5 | 1 | 5 | 2.0 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CC[C@H](N3CCCC3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 16221108 | 85092 | 0 | None | 22 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227600 | 85092 | 0 | None | 22 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| 44579969 | 186308 | 0 | None | - | 1 | Crab-eating macaque | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 509 | 9 | 1 | 5 | 4.5 | CN(Cc1ccc(CN2CCCCC2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL489810 | 186308 | 0 | None | - | 1 | Crab-eating macaque | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 509 | 9 | 1 | 5 | 4.5 | CN(Cc1ccc(CN2CCCCC2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 44580043 | 184149 | 0 | None | - | 1 | Crab-eating macaque | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 460 | 6 | 1 | 5 | 3.6 | O=C(NCCC(=O)N1CCC2(CCOCC2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL485079 | 184149 | 0 | None | - | 1 | Crab-eating macaque | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 460 | 6 | 1 | 5 | 3.6 | O=C(NCCC(=O)N1CCC2(CCOCC2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 25105469 | 186468 | 6 | None | -2 | 2 | Crab-eating macaque | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 467 | 8 | 3 | 7 | 2.6 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491198 | 186468 | 6 | None | -2 | 2 | Crab-eating macaque | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 467 | 8 | 3 | 7 | 2.6 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc(C2=NCCN2)nc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 60142027 | 125359 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648454 | 125359 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 54584600 | 61848 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777965 | 61848 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56589598 | 65436 | 0 | None | -7 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 543 | 5 | 1 | 6 | 5.2 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| CHEMBL1834751 | 65436 | 0 | None | -7 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 543 | 5 | 1 | 6 | 5.2 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| 46230835 | 199306 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 439 | 4 | 2 | 6 | 4.6 | Cc1nc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL602115 | 199306 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 439 | 4 | 2 | 6 | 4.6 | Cc1nc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| 25195622 | 61838 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 606 | 7 | 2 | 5 | 4.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777955 | 61838 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 606 | 7 | 2 | 5 | 4.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2011.03.115 | ||
| 54587553 | 61862 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 540 | 8 | 3 | 5 | 3.2 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777979 | 61862 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 540 | 8 | 3 | 5 | 3.2 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 60142441 | 125377 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 540 | 5 | 2 | 6 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648471 | 125377 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 540 | 5 | 2 | 6 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 11442712 | 84788 | 0 | None | -9 | 2 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL225607 | 84788 | 0 | None | -9 | 2 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 54581666 | 61853 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777970 | 61853 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 57399382 | 69496 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 482 | 5 | 1 | 5 | 2.3 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC(N(C)C)CC2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1938412 | 69496 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 482 | 5 | 1 | 5 | 2.3 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC(N(C)C)CC2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 60141042 | 125403 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 537 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 | nan | ||
| CHEMBL3648497 | 125403 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 537 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 | nan | ||
| 11663809 | 173019 | 0 | None | -5 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 8 | 3 | 6 | 3.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453339 | 173019 | 0 | None | -5 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 8 | 3 | 6 | 3.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 16221228 | 165453 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 593 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL425490 | 165453 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 593 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 57398239 | 69747 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 460 | 5 | 1 | 5 | 1.5 | CN(C)[C@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939945 | 69747 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 460 | 5 | 1 | 5 | 1.5 | CN(C)[C@H]1CCN(C(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2cccc(Cl)c2Cl)C1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11526891 | 188281 | 0 | None | -1 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL507168 | 188281 | 0 | None | -1 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 23630810 | 143957 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 452 | 7 | 3 | 5 | 3.7 | O=C(NCCC1CCN(c2ccncc2)CC1)c1cc(NC(=O)c2ccccc2Cl)[nH]n1 | 10.1021/jm051292n | ||
| CHEMBL390692 | 143957 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 452 | 7 | 3 | 5 | 3.7 | O=C(NCCC1CCN(c2ccncc2)CC1)c1cc(NC(=O)c2ccccc2Cl)[nH]n1 | 10.1021/jm051292n | ||
| 137657568 | 158989 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 1920 | 23 | 21 | 26 | -5.4 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N2 | 10.1021/acs.jmedchem.6b01011 | ||
| CHEMBL4102547 | 158989 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 1920 | 23 | 21 | 26 | -5.4 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N2 | 10.1021/acs.jmedchem.6b01011 | ||
| 16220988 | 85096 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227697 | 85096 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 | 10.1021/jm070055c | ||
| 11405561 | 91761 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 354 | 4 | 3 | 3 | 3.9 | Cc1c(C(=O)Nc2ccccc2)n[nH]c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL242565 | 91761 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 354 | 4 | 3 | 3 | 3.9 | Cc1c(C(=O)Nc2ccccc2)n[nH]c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| 16221053 | 141805 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 573 | 9 | 3 | 5 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL388720 | 141805 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 573 | 9 | 3 | 5 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 16220986 | 137079 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL375709 | 137079 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| 17751868 | 69728 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 393 | 5 | 2 | 5 | 0.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939926 | 69728 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 393 | 5 | 2 | 5 | 0.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 49863230 | 15041 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 597 | 10 | 2 | 4 | 6.0 | C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210747 | 15041 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 597 | 10 | 2 | 4 | 6.0 | C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 16221226 | 143853 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 569 | 9 | 3 | 5 | 5.6 | Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL390603 | 143853 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 569 | 9 | 3 | 5 | 5.6 | Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 | 10.1021/jm070055c | ||
| 70691814 | 73490 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 592 | 8 | 2 | 5 | 5.6 | Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018868 | 73490 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 592 | 8 | 2 | 5 | 5.6 | Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C | 10.1016/j.bmcl.2012.03.065 | ||
| 23627521 | 73495 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 648 | 9 | 2 | 6 | 6.0 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018873 | 73495 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 648 | 9 | 2 | 6 | 6.0 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 56594642 | 65377 | 0 | None | -21 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834616 | 65377 | 0 | None | -21 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 57398980 | 69711 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 440 | 5 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939768 | 69711 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 440 | 5 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 23630510 | 92852 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 446 | 5 | 3 | 3 | 4.6 | C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| CHEMBL245129 | 92852 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 446 | 5 | 3 | 3 | 4.6 | C[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| 11635364 | 173980 | 0 | None | -4 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL455643 | 173980 | 0 | None | -4 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 44410186 | 76849 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 615 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL207945 | 76849 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 615 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 16220914 | 85129 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 529 | 9 | 3 | 5 | 4.6 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL228014 | 85129 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 529 | 9 | 3 | 5 | 4.6 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 44580013 | 186454 | 0 | None | - | 1 | Crab-eating macaque | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 478 | 8 | 2 | 5 | 3.9 | CN(Cc1ccc(-c2ccn[nH]2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491042 | 186454 | 0 | None | - | 1 | Crab-eating macaque | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 478 | 8 | 2 | 5 | 3.9 | CN(Cc1ccc(-c2ccn[nH]2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 11444165 | 140335 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 545 | 7 | 2 | 4 | 5.7 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381979 | 140335 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 545 | 7 | 2 | 4 | 5.7 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl | 10.1016/j.bmcl.2006.01.069 | ||
| 60142024 | 125356 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 446 | 5 | 2 | 4 | 3.5 | COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| CHEMBL3648451 | 125356 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 446 | 5 | 2 | 4 | 3.5 | COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| 49863233 | 15044 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 615 | 13 | 3 | 5 | 5.6 | C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210750 | 15044 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 615 | 13 | 3 | 5 | 5.6 | C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 44587207 | 187555 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 573 | 6 | 2 | 6 | 4.4 | O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL498489 | 187555 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 573 | 6 | 2 | 6 | 4.4 | O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 23630811 | 91878 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 470 | 7 | 3 | 5 | 3.9 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1F)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL242995 | 91878 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 470 | 7 | 3 | 5 | 3.9 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1F)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44579830 | 186400 | 0 | None | -1 | 2 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 516 | 8 | 0 | 6 | 3.2 | CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490619 | 186400 | 0 | None | -1 | 2 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 516 | 8 | 0 | 6 | 3.2 | CCCN(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 57394688 | 69752 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 508 | 5 | 1 | 5 | 2.8 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC[C@H](N3CCCC3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939950 | 69752 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 508 | 5 | 1 | 5 | 2.8 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCC[C@H](N3CCCC3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 11307733 | 74532 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 579 | 8 | 2 | 4 | 6.0 | CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL203174 | 74532 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 579 | 8 | 2 | 4 | 6.0 | CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44579866 | 192573 | 0 | None | - | 1 | Crab-eating macaque | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 508 | 5 | 0 | 6 | 3.7 | O=C(c1nc2ccccc2n1Cc1ccccc1)N1CCC(C(=O)N2CCN(c3ccncc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL523266 | 192573 | 0 | None | - | 1 | Crab-eating macaque | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 508 | 5 | 0 | 6 | 3.7 | O=C(c1nc2ccccc2n1Cc1ccccc1)N1CCC(C(=O)N2CCN(c3ccncc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 54585539 | 61856 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777973 | 61856 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 54585539 | 61856 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1777973 | 61856 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 56835163 | 69210 | 0 | None | -1 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934264 | 69210 | 0 | None | -1 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 16220990 | 85107 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227786 | 85107 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 60142167 | 125363 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 2.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 | nan | ||
| CHEMBL3648458 | 125363 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 2.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 | nan | ||
| 88925471 | 125371 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 3.5 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648465 | 125371 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 3.5 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 60142305 | 125370 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 5 | 2 | 6 | 4.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648464 | 125370 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 5 | 2 | 6 | 4.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 44410143 | 76968 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 497 | 7 | 2 | 4 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL208386 | 76968 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 497 | 7 | 2 | 4 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 54587550 | 61842 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777959 | 61842 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 57390932 | 69200 | 0 | None | -14 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934254 | 69200 | 0 | None | -14 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 17751827 | 69730 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 421 | 5 | 2 | 5 | 1.3 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939928 | 69730 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 421 | 5 | 2 | 5 | 1.3 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCOCC2(C)C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44561643 | 185056 | 0 | None | -5 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 542 | 8 | 3 | 6 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL486456 | 185056 | 0 | None | -5 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 542 | 8 | 3 | 6 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57391172 | 69726 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 405 | 5 | 2 | 4 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939924 | 69726 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 405 | 5 | 2 | 4 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 71449505 | 80497 | 0 | None | -3 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 475 | 8 | 1 | 5 | 5.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)c(F)c1 | 10.1016/j.bmcl.2011.04.091 | ||
| CHEMBL2153436 | 80497 | 0 | None | -3 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 475 | 8 | 1 | 5 | 5.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CCCc2ccc3cccnc3n2)c(F)c1 | 10.1016/j.bmcl.2011.04.091 | ||
| 16221225 | 168791 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL442056 | 168791 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| 57401426 | 69208 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934262 | 69208 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 24946440 | 192440 | 0 | None | - | 1 | Crab-eating macaque | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 488 | 6 | 0 | 6 | 2.4 | CN1CCC(N2CCN(C(=O)CN(C)C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL522308 | 192440 | 0 | None | - | 1 | Crab-eating macaque | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 488 | 6 | 0 | 6 | 2.4 | CN1CCC(N2CCN(C(=O)CN(C)C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 44579812 | 186542 | 0 | None | - | 1 | Crab-eating macaque | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 482 | 7 | 0 | 6 | 3.3 | CCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491830 | 186542 | 0 | None | - | 1 | Crab-eating macaque | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 482 | 7 | 0 | 6 | 3.3 | CCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 57390933 | 69201 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934255 | 69201 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 46229968 | 199690 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 6 | 2 | 4 | 4.5 | C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL604575 | 199690 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 538 | 6 | 2 | 4 | 4.5 | C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)c(F)c1 | 10.1016/j.bmcl.2009.11.119 | ||
| 23627396 | 73489 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 618 | 8 | 2 | 5 | 6.0 | O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018867 | 73489 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 618 | 8 | 2 | 5 | 6.0 | O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 60142166 | 125362 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 538 | 5 | 2 | 6 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 | nan | ||
| CHEMBL3648457 | 125362 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 538 | 5 | 2 | 6 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 | nan | ||
| 11375297 | 92126 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 490 | 6 | 3 | 5 | 3.7 | COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| CHEMBL243467 | 92126 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 490 | 6 | 3 | 5 | 3.7 | COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| 23630509 | 92825 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 453 | 4 | 4 | 4 | 2.5 | O=C(Nc1[nH]nc(C(=O)N[C@@H]2CCCCNC2=O)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL244955 | 92825 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 453 | 4 | 4 | 4 | 2.5 | O=C(Nc1[nH]nc(C(=O)N[C@@H]2CCCCNC2=O)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44580044 | 184150 | 0 | None | - | 1 | Crab-eating macaque | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 459 | 6 | 1 | 5 | 3.1 | CN1CCC2(CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)C1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL485080 | 184150 | 0 | None | - | 1 | Crab-eating macaque | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 459 | 6 | 1 | 5 | 3.1 | CN1CCC2(CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)C1 | 10.1016/j.bmcl.2008.08.014 | ||
| 11620980 | 173130 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453596 | 173130 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.108 | ||
| 23631902 | 161303 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 530 | 7 | 3 | 5 | 4.5 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL414892 | 161303 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 530 | 7 | 3 | 5 | 4.5 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 11215677 | 61840 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 614 | 7 | 2 | 6 | 4.6 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777957 | 61840 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 614 | 7 | 2 | 6 | 4.6 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 11561240 | 69704 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 439 | 5 | 2 | 4 | 2.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939761 | 69704 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 439 | 5 | 2 | 4 | 2.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 16108961 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm070055c | ||
| 664 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm070055c | ||
| CHEMBL415848 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm070055c | ||
| 16108961 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 664 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| CHEMBL415848 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 60142705 | 125385 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 536 | 6 | 2 | 8 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 | nan | ||
| CHEMBL3648479 | 125385 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 536 | 6 | 2 | 8 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 | nan | ||
| 46230354 | 199768 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 541 | 8 | 3 | 9 | 5.2 | COc1cc(C(=O)Nc2c[nH]nc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL604999 | 199768 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 541 | 8 | 3 | 9 | 5.2 | COc1cc(C(=O)Nc2c[nH]nc2NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| 23630919 | 142014 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 606 | 8 | 2 | 6 | 6.0 | O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccc1)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL389097 | 142014 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 606 | 8 | 2 | 6 | 6.0 | O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1-c1ccccc1)c1ccccc1Cl | 10.1021/jm051292n | ||
| 23631902 | 161303 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 530 | 7 | 3 | 5 | 4.5 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl | 10.1021/jm1000776 | ||
| CHEMBL414892 | 161303 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 530 | 7 | 3 | 5 | 4.5 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Br)c1ccccc1Cl | 10.1021/jm1000776 | ||
| 46230889 | 198800 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 419 | 4 | 2 | 6 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(C)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL598665 | 198800 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 419 | 4 | 2 | 6 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(C)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| 54581664 | 61843 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777960 | 61843 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 60142439 | 125376 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 524 | 5 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648470 | 125376 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 524 | 5 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 60142837 | 125392 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 5 | 2 | 7 | 5.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| CHEMBL3648486 | 125392 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 5 | 2 | 7 | 5.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| 11225601 | 141483 | 0 | None | -3 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| CHEMBL387638 | 141483 | 0 | None | -3 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| 46230989 | 198495 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 477 | 5 | 2 | 7 | 4.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCCC3)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL596623 | 198495 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 477 | 5 | 2 | 7 | 4.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)N(O)C3CCCCC3)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| 11433587 | 15039 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210745 | 15039 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 23630511 | 144230 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 486 | 7 | 3 | 5 | 4.4 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Cl)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL390916 | 144230 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 486 | 7 | 3 | 5 | 4.4 | O=C(Nc1[nH]nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c1Cl)c1ccccc1Cl | 10.1021/jm051292n | ||
| 56835162 | 69206 | 0 | None | -7 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934260 | 69206 | 0 | None | -7 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 11519239 | 185168 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL486640 | 185168 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 60142961 | 125393 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 427 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648487 | 125393 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 427 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3038096 | 209175 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 16108966 | 83945 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 555 | 10 | 2 | 4 | 6.1 | C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL221925 | 83945 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 555 | 10 | 2 | 4 | 6.1 | C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 46230836 | 197575 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 389 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cccc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL590153 | 197575 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 389 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cccc2-c2cnc([C@@H](C)NC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| 11203826 | 139579 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 563 | 9 | 2 | 4 | 5.3 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL380117 | 139579 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 563 | 9 | 2 | 4 | 5.3 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 56594770 | 65382 | 0 | None | -7 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834620 | 65382 | 0 | None | -7 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 24946265 | 186471 | 0 | None | 1 | 2 | Crab-eating macaque | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 454 | 6 | 1 | 6 | 2.6 | O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491219 | 186471 | 0 | None | 1 | 2 | Crab-eating macaque | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 454 | 6 | 1 | 6 | 2.6 | O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 42605727 | 197717 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 409 | 8 | 2 | 5 | 2.1 | CCN(CC)C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL591111 | 197717 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 409 | 8 | 2 | 5 | 2.1 | CCN(CC)C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 | 10.1016/j.bmcl.2009.11.119 | ||
| 57399885 | 69725 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 405 | 5 | 2 | 4 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCC(C)CC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939923 | 69725 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 405 | 5 | 2 | 4 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCC(C)CC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 49863227 | 15035 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 627 | 10 | 2 | 4 | 6.9 | CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210741 | 15035 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 627 | 10 | 2 | 4 | 6.9 | CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 46230890 | 199565 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 408 | 4 | 2 | 5 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc(CNC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL603894 | 199565 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 408 | 4 | 2 | 5 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc(CNC(=O)N(C)O)c(F)c2)no1 | 10.1016/j.bmcl.2009.11.121 | ||
| 49863232 | 15043 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 601 | 12 | 4 | 5 | 4.9 | C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210749 | 15043 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 601 | 12 | 4 | 5 | 4.9 | C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 23631015 | 92511 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 626 | 8 | 2 | 6 | 5.5 | CN1CCC(N2CCC(CCNC(=O)c3nn(-c4ccccc4)c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 | 10.1021/jm051292n | ||
| CHEMBL244124 | 92511 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 626 | 8 | 2 | 6 | 5.5 | CN1CCC(N2CCC(CCNC(=O)c3nn(-c4ccccc4)c(NC(=O)c4ccccc4Cl)c3Br)CC2)CC1 | 10.1021/jm051292n | ||
| 2818985 | 92751 | 5 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 431 | 3 | 2 | 2 | 6.0 | CC(C)(C)c1ccc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cc1 | 10.1021/jm051292n | ||
| CHEMBL244522 | 92751 | 5 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 431 | 3 | 2 | 2 | 6.0 | CC(C)(C)c1ccc(-c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)cc1 | 10.1021/jm051292n | ||
| 44579913 | 183579 | 0 | None | - | 1 | Crab-eating macaque | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 514 | 5 | 0 | 6 | 2.9 | CN1CCC(N2CCN(C(=O)[C@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL483036 | 183579 | 0 | None | - | 1 | Crab-eating macaque | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 514 | 5 | 0 | 6 | 2.9 | CN1CCC(N2CCN(C(=O)[C@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 44419046 | 97809 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 595 | 10 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCc2cc(CCN3CCCCC3)ccc2C1 | 10.1021/jm061224g | ||
| CHEMBL274624 | 97809 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 595 | 10 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCc2cc(CCN3CCCCC3)ccc2C1 | 10.1021/jm061224g | ||
| 659 | 2842 | 13 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| 9831083 | 2842 | 13 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| CHEMBL273869 | 2842 | 13 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| 44579968 | 192512 | 0 | None | - | 1 | Crab-eating macaque | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 490 | 8 | 1 | 6 | 3.9 | CN(Cc1ccc(-c2ncccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL522789 | 192512 | 0 | None | - | 1 | Crab-eating macaque | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 490 | 8 | 1 | 6 | 3.9 | CN(Cc1ccc(-c2ncccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 16220989 | 141955 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL389054 | 141955 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| 60142568 | 125379 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 526 | 5 | 2 | 6 | 5.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| CHEMBL3648473 | 125379 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 526 | 5 | 2 | 6 | 5.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| 56594373 | 65537 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1835762 | 65537 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| 56594771 | 65434 | 0 | None | -2 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 507 | 5 | 1 | 6 | 4.9 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 | 10.1021/jm200808v | ||
| CHEMBL1834749 | 65434 | 0 | None | -2 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 507 | 5 | 1 | 6 | 4.9 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 | 10.1021/jm200808v | ||
| 44579652 | 186584 | 0 | None | -57 | 2 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 508 | 9 | 1 | 6 | 3.6 | CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL492211 | 186584 | 0 | None | -57 | 2 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 508 | 9 | 1 | 6 | 3.6 | CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 60142963 | 125395 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648489 | 125395 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 46230308 | 199891 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 393 | 5 | 2 | 4 | 4.9 | COC(=O)c1c(F)cccc1-c1ccc(CNc2nc3ccccc3[nH]2)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL605634 | 199891 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 393 | 5 | 2 | 4 | 4.9 | COC(=O)c1c(F)cccc1-c1ccc(CNc2nc3ccccc3[nH]2)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| 46230259 | 198781 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.1 | COC(=O)c1c(F)cccc1-c1ccc(CNC(C)=O)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL598552 | 198781 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.1 | COC(=O)c1c(F)cccc1-c1ccc(CNC(C)=O)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| 16220913 | 85112 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 515 | 8 | 3 | 5 | 4.3 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227828 | 85112 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 515 | 8 | 3 | 5 | 4.3 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 44579829 | 186399 | 0 | None | 1 | 2 | Crab-eating macaque | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 496 | 8 | 0 | 6 | 3.7 | CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490618 | 186399 | 0 | None | 1 | 2 | Crab-eating macaque | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 496 | 8 | 0 | 6 | 3.7 | CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 16108967 | 83912 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL221691 | 83912 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 57395451 | 69709 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 2.5 | COc1cccc2c1CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939766 | 69709 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 2.5 | COc1cccc2c1CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57394687 | 69751 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 494 | 5 | 1 | 5 | 2.4 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC[C@H](N3CCCC3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939949 | 69751 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 494 | 5 | 1 | 5 | 2.4 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC[C@H](N3CCCC3)C2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL3038105 | 209183 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N(CC(=O)N1C2CCCCC2C[C@H]1C(=O)O)Cc1ccccc1 | 10.1021/jm950716i | ||||
| 11555433 | 188392 | 0 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 520 | 8 | 3 | 6 | 3.0 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL508632 | 188392 | 0 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 520 | 8 | 3 | 6 | 3.0 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57403174 | 69202 | 0 | None | -5 | 2 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934256 | 69202 | 0 | None | -5 | 2 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 44579829 | 186399 | 0 | None | -1 | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 496 | 8 | 0 | 6 | 3.7 | CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490618 | 186399 | 0 | None | -1 | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 496 | 8 | 0 | 6 | 3.7 | CCCN(CC(=O)N1CCN(c2ccncc2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 56835162 | 69206 | 0 | None | 7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934260 | 69206 | 0 | None | 7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 56594770 | 65382 | 0 | None | 7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834620 | 65382 | 0 | None | 7 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 11663809 | 173019 | 0 | None | 5 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 536 | 8 | 3 | 6 | 3.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453339 | 173019 | 0 | None | 5 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 536 | 8 | 3 | 6 | 3.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 16108961 | 908 | 0 | None | -2 | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 664 | 908 | 0 | None | -2 | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| CHEMBL415848 | 908 | 0 | None | -2 | 3 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 60142302 | 125367 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 536 | 5 | 2 | 5 | 5.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648461 | 125367 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 536 | 5 | 2 | 5 | 5.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60141039 | 125401 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 553 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| CHEMBL3648495 | 125401 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 553 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| 53248885 | 61841 | 0 | None | -18 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1021/jm200808v | ||
| CHEMBL1777958 | 61841 | 0 | None | -18 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1021/jm200808v | ||
| 54582656 | 61857 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 510 | 8 | 3 | 5 | 2.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777974 | 61857 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 510 | 8 | 3 | 5 | 2.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 11635365 | 173979 | 0 | None | 2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL455642 | 173979 | 0 | None | 2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 60141181 | 125404 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 551 | 6 | 2 | 8 | 4.1 | Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| CHEMBL3648498 | 125404 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 551 | 6 | 2 | 8 | 4.1 | Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| 46230068 | 199353 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 4.4 | C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)N(C)NC(=O)c2cc(F)cc(C(F)(F)F)c2)c(F)c1 | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL602555 | 199353 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 4.4 | C[C@H]1CC[C@@H](C)N1C(=O)c1cnc([C@@H](C)NC(=O)N(C)NC(=O)c2cc(F)cc(C(F)(F)F)c2)c(F)c1 | 10.1016/j.bmcl.2009.11.119 | ||
| 44561643 | 185056 | 0 | None | 5 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 542 | 8 | 3 | 6 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL486456 | 185056 | 0 | None | 5 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 542 | 8 | 3 | 6 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 60142566 | 125375 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 524 | 5 | 2 | 6 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648469 | 125375 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 524 | 5 | 2 | 6 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 46230938 | 199576 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 423 | 5 | 2 | 7 | 2.8 | CCN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL603962 | 199576 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 423 | 5 | 2 | 7 | 2.8 | CCN(O)C(=O)NCc1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2009.11.121 | ||
| 46216744 | 199886 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 508 | 6 | 2 | 7 | 5.7 | CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc2ccccc21 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL605570 | 199886 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 508 | 6 | 2 | 7 | 5.7 | CC(=O)Nn1c(NCc2ccc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)nc2ccccc21 | 10.1016/j.bmcl.2009.11.120 | ||
| 60143099 | 125399 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 534 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648493 | 125399 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 534 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 57394689 | 69753 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 496 | 5 | 1 | 5 | 2.6 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCCC(N(C)C)CC2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939951 | 69753 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 496 | 5 | 1 | 5 | 2.6 | Cc1cc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCCCC(N(C)C)CC2)c(C)cc1Cl | 10.1016/j.bmcl.2011.11.112 | ||
| 60141327 | 125413 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 554 | 6 | 2 | 10 | 3.3 | Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 | nan | ||
| CHEMBL3648507 | 125413 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 554 | 6 | 2 | 10 | 3.3 | Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 | nan | ||
| 57395702 | 69715 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 5 | 2 | 5 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(=O)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939771 | 69715 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 5 | 2 | 5 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC(=O)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44579889 | 186023 | 0 | None | - | 1 | Crab-eating macaque | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 528 | 5 | 0 | 6 | 3.2 | CN1CCC(N2CCN(C(=O)C3CCN(C(=O)c4nc5ccccc5n4Cc4ccccc4)CC3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL487908 | 186023 | 0 | None | - | 1 | Crab-eating macaque | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 528 | 5 | 0 | 6 | 3.2 | CN1CCC(N2CCN(C(=O)C3CCN(C(=O)c4nc5ccccc5n4Cc4ccccc4)CC3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 137640759 | 156528 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1756 | 21 | 21 | 23 | -5.9 | CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.6b01011 | ||
| CHEMBL4074308 | 156528 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1756 | 21 | 21 | 23 | -5.9 | CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2 | 10.1021/acs.jmedchem.6b01011 | ||
| 44579967 | 186430 | 0 | None | - | 1 | Crab-eating macaque | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 489 | 8 | 1 | 5 | 4.5 | CN(Cc1ccc(-c2ccccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490827 | 186430 | 0 | None | - | 1 | Crab-eating macaque | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 489 | 8 | 1 | 5 | 4.5 | CN(Cc1ccc(-c2ccccn2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 44579891 | 191487 | 0 | None | - | 1 | Crab-eating macaque | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 494 | 5 | 0 | 6 | 3.4 | O=C([C@H]1CCCN1C(=O)c1nc2ccccc2n1Cc1ccccc1)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL520304 | 191487 | 0 | None | - | 1 | Crab-eating macaque | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 494 | 5 | 0 | 6 | 3.4 | O=C([C@H]1CCCN1C(=O)c1nc2ccccc2n1Cc1ccccc1)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 11331054 | 15037 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 625 | 10 | 2 | 4 | 6.8 | C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210743 | 15037 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 625 | 10 | 2 | 4 | 6.8 | C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 24946265 | 186471 | 0 | None | -1 | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 454 | 6 | 1 | 6 | 2.6 | O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL491219 | 186471 | 0 | None | -1 | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 454 | 6 | 1 | 6 | 2.6 | O=C(NCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 16108962 | 141176 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL385740 | 141176 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 46911684 | 15047 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 599 | 11 | 3 | 4 | 6.3 | C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210753 | 15047 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 599 | 11 | 3 | 4 | 6.3 | C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 23627523 | 73494 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 654 | 8 | 2 | 5 | 6.3 | O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018872 | 73494 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 654 | 8 | 2 | 5 | 6.3 | O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 11215189 | 168217 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 565 | 9 | 2 | 4 | 5.6 | CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL437509 | 168217 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 565 | 9 | 2 | 4 | 5.6 | CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 46230306 | 198512 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 345 | 4 | 0 | 3 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CN2CCCC2=O)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL596718 | 198512 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 345 | 4 | 0 | 3 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CN2CCCC2=O)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| 23627583 | 73496 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 655 | 9 | 1 | 5 | 7.5 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018874 | 73496 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 655 | 9 | 1 | 5 | 7.5 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| 44410254 | 75590 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205242 | 75590 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410020 | 137679 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 549 | 7 | 1 | 4 | 5.0 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL377011 | 137679 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 549 | 7 | 1 | 4 | 5.0 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 49863236 | 15048 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 611 | 11 | 3 | 4 | 6.5 | C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210754 | 15048 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 611 | 11 | 3 | 4 | 6.5 | C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 23630918 | 92300 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.5 | Cn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL243650 | 92300 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.5 | Cn1nc(C(=O)NCCC2CCN(c3ccncc3)CC2)c(Br)c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| 11635364 | 173980 | 0 | None | 4 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL455643 | 173980 | 0 | None | 4 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 44410250 | 75587 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205227 | 75587 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 16108968 | 165574 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL426165 | 165574 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 16202227 | 73493 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 636 | 8 | 2 | 5 | 6.1 | O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018871 | 73493 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 636 | 8 | 2 | 5 | 6.1 | O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 16220915 | 85095 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 557 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227690 | 85095 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 557 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 16221108 | 85092 | 0 | None | -22 | 2 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227600 | 85092 | 0 | None | -22 | 2 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| 60142165 | 125361 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 496 | 5 | 2 | 5 | 3.3 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 | nan | ||
| CHEMBL3648456 | 125361 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 496 | 5 | 2 | 5 | 3.3 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 | nan | ||
| CHEMBL3038103 | 209181 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1)C1CCCC1 | 10.1021/jm950716i | ||||
| 11478613 | 140048 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 567 | 10 | 2 | 5 | 4.6 | COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381372 | 140048 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 567 | 10 | 2 | 5 | 4.6 | COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 16221229 | 85128 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 605 | 10 | 3 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227977 | 85128 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 605 | 10 | 3 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 | 10.1021/jm070055c | ||
| 44579850 | 186573 | 0 | None | - | 1 | Crab-eating macaque | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 516 | 7 | 0 | 6 | 3.2 | CC(C)N(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL492048 | 186573 | 0 | None | - | 1 | Crab-eating macaque | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 516 | 7 | 0 | 6 | 3.2 | CC(C)N(CC(=O)N1CCN(C2CCN(C)CC2)CC1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 49863237 | 15049 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 625 | 11 | 3 | 4 | 6.9 | C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210755 | 15049 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 625 | 11 | 3 | 4 | 6.9 | C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 11330286 | 76102 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 549 | 8 | 2 | 4 | 5.1 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205981 | 76102 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 549 | 8 | 2 | 4 | 5.1 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 60142026 | 125358 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 480 | 5 | 2 | 4 | 4.1 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| CHEMBL3648453 | 125358 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 480 | 5 | 2 | 4 | 4.1 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| 54583583 | 61828 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 462 | 6 | 2 | 5 | 1.3 | CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777880 | 61828 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 462 | 6 | 2 | 5 | 1.3 | CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594241 | 65531 | 0 | None | -4 | 2 | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1835756 | 65531 | 0 | None | -4 | 2 | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 11663606 | 192972 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL530554 | 192972 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 23630513 | 143434 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 542 | 5 | 4 | 5 | 4.0 | O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| CHEMBL390272 | 143434 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 542 | 5 | 4 | 5 | 4.0 | O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| 11224694 | 92320 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 447 | 6 | 3 | 4 | 3.4 | O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL243667 | 92320 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 447 | 6 | 3 | 4 | 3.4 | O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44579795 | 186352 | 0 | None | 30 | 2 | Crab-eating macaque | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490201 | 186352 | 0 | None | 30 | 2 | Crab-eating macaque | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 480 | 8 | 2 | 6 | 2.8 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 42606292 | 197848 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 519 | 6 | 2 | 3 | 5.0 | CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)cc1 | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL592238 | 197848 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 519 | 6 | 2 | 3 | 5.0 | CC1CCC(C)N1C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(F)cc(C(F)(F)F)c3)CC2)cc1 | 10.1016/j.bmcl.2009.11.119 | ||
| 60142569 | 125380 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 426 | 4 | 2 | 5 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648474 | 125380 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 426 | 4 | 2 | 5 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 | nan | ||
| 11478717 | 92342 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 576 | 5 | 4 | 5 | 4.6 | O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL243679 | 92342 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 576 | 5 | 4 | 5 | 4.6 | O=C(Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 16108969 | 82604 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL218152 | 82604 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 16108969 | 82604 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL218152 | 82604 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 16108960 | 168682 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL441188 | 168682 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 60141183 | 125406 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 527 | 5 | 2 | 8 | 3.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 | nan | ||
| CHEMBL3648500 | 125406 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 527 | 5 | 2 | 8 | 3.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 | nan | ||
| 11670860 | 185170 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL486641 | 185170 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 42606173 | 197718 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 437 | 8 | 2 | 5 | 2.9 | CC(C)N(C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1)C(C)C | 10.1016/j.bmcl.2009.11.119 | ||
| CHEMBL591112 | 197718 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 437 | 8 | 2 | 5 | 2.9 | CC(C)N(C(=O)c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)CC2)cc1)C(C)C | 10.1016/j.bmcl.2009.11.119 | ||
| 16108963 | 161406 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL415849 | 161406 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 23627458 | 73491 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 564 | 8 | 2 | 5 | 5.0 | Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018869 | 73491 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 564 | 8 | 2 | 5 | 5.0 | Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 44579849 | 186307 | 0 | None | - | 1 | Crab-eating macaque | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 7 | 3 | 5 | 3.7 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2cn[nH]c2c1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL489808 | 186307 | 0 | None | - | 1 | Crab-eating macaque | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 7 | 3 | 5 | 3.7 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2cn[nH]c2c1 | 10.1016/j.bmcl.2008.08.014 | ||
| 11452874 | 151845 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 418 | 4 | 3 | 3 | 4.3 | O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL397037 | 151845 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 418 | 4 | 3 | 3 | 4.3 | O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44579865 | 186210 | 0 | None | - | 1 | Crab-eating macaque | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 494 | 9 | 2 | 6 | 3.2 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CCNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL489203 | 186210 | 0 | None | - | 1 | Crab-eating macaque | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 494 | 9 | 2 | 6 | 3.2 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)CCNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 11238372 | 168463 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 563 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL439505 | 168463 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 563 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 44419100 | 82737 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 555 | 11 | 2 | 4 | 5.6 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL218314 | 82737 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 555 | 11 | 2 | 4 | 5.6 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 44410179 | 165752 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 573 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL427208 | 165752 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 573 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11373520 | 151517 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 419 | 4 | 3 | 4 | 3.7 | O=C(Nc1[nH]nc(C(=O)Nc2ccncc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL396735 | 151517 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 419 | 4 | 3 | 4 | 3.7 | O=C(Nc1[nH]nc(C(=O)Nc2ccncc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 16221227 | 142474 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 614 | 9 | 3 | 6 | 5.5 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 | 10.1021/jm070055c | ||
| CHEMBL389477 | 142474 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 614 | 9 | 3 | 6 | 5.5 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 | 10.1021/jm070055c | ||
| 16221163 | 85131 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL228030 | 85131 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| 46230892 | 198837 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 395 | 4 | 3 | 7 | 2.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)NO)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| CHEMBL598868 | 198837 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 395 | 4 | 3 | 7 | 2.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc(CNC(=O)NO)c(F)c2)n1 | 10.1016/j.bmcl.2009.11.121 | ||
| 44410269 | 165570 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 569 | 11 | 2 | 5 | 5.9 | CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL426130 | 165570 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 569 | 11 | 2 | 5 | 5.9 | CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44579652 | 186584 | 0 | None | 57 | 2 | Crab-eating macaque | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 508 | 9 | 1 | 6 | 3.6 | CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL492211 | 186584 | 0 | None | 57 | 2 | Crab-eating macaque | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 508 | 9 | 1 | 6 | 3.6 | CCN(CC(=O)N(C)Cc1ccc(C2=NCCN2)cc1)C(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 44419045 | 136751 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL375229 | 136751 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NC1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 23630809 | 166795 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 451 | 4 | 3 | 4 | 2.9 | O=C(Nc1[nH]nc(C(=O)N[C@@H]2CN3CCC2CC3)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL429463 | 166795 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 451 | 4 | 3 | 4 | 2.9 | O=C(Nc1[nH]nc(C(=O)N[C@@H]2CN3CCC2CC3)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 16221110 | 84597 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 543 | 10 | 3 | 5 | 5.0 | CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL224071 | 84597 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 543 | 10 | 3 | 5 | 5.0 | CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 16221164 | 161185 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 577 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL413786 | 161185 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 577 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| 24946267 | 186401 | 0 | None | - | 1 | Crab-eating macaque | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 488 | 7 | 1 | 6 | 2.4 | CN1CCC(N2CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL490626 | 186401 | 0 | None | - | 1 | Crab-eating macaque | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 488 | 7 | 1 | 6 | 2.4 | CN1CCC(N2CCN(C(=O)CCNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 60141184 | 125407 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 427 | 4 | 2 | 7 | 2.3 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 | nan | ||
| CHEMBL3648501 | 125407 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 427 | 4 | 2 | 7 | 2.3 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 | nan | ||
| 46230307 | 199530 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 393 | 4 | 0 | 3 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CN2Cc3ccccc3C2=O)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL603657 | 199530 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 393 | 4 | 0 | 3 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CN2Cc3ccccc3C2=O)c(F)c1 | 10.1016/j.bmcl.2009.11.120 | ||
| 44587206 | 187554 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 6 | 3 | 6 | 4.0 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL498488 | 187554 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 6 | 3 | 6 | 4.0 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 44579945 | 186237 | 0 | None | - | 1 | Crab-eating macaque | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 478 | 8 | 1 | 6 | 3.7 | CN(Cc1ccc(-n2ccnc2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL489389 | 186237 | 0 | None | - | 1 | Crab-eating macaque | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 478 | 8 | 1 | 6 | 3.7 | CN(Cc1ccc(-n2ccnc2)cc1)C(=O)CNC(=O)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 23630612 | 91636 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.5 | Cn1nc(NC(=O)c2ccccc2Cl)c(Br)c1C(=O)NCCC1CCN(c2ccncc2)CC1 | 10.1021/jm051292n | ||
| CHEMBL241935 | 91636 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 544 | 7 | 2 | 6 | 4.5 | Cn1nc(NC(=O)c2ccccc2Cl)c(Br)c1C(=O)NCCC1CCN(c2ccncc2)CC1 | 10.1021/jm051292n | ||
| 23630814 | 151559 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 508 | 5 | 4 | 5 | 3.3 | CC(C)C(=O)Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br | 10.1021/jm051292n | ||
| CHEMBL396771 | 151559 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 508 | 5 | 4 | 5 | 3.3 | CC(C)C(=O)Nc1[nH]nc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)c1Br | 10.1021/jm051292n | ||
| 57399671 | 69211 | 0 | None | 2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 506 | 5 | 1 | 4 | 6.6 | Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934265 | 69211 | 0 | None | 2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 506 | 5 | 1 | 4 | 6.6 | Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 | 10.1016/j.bmcl.2011.10.068 | ||
| 11444270 | 76351 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 553 | 7 | 2 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206554 | 76351 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 553 | 7 | 2 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 24755613 | 192514 | 0 | None | - | 1 | Crab-eating macaque | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 2.1 | CN1CCC(N2CCN(C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL522798 | 192514 | 0 | None | - | 1 | Crab-eating macaque | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 474 | 6 | 1 | 6 | 2.1 | CN1CCC(N2CCN(C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 16221160 | 96808 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 10 | 3 | 5 | 6.3 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL268911 | 96808 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 10 | 3 | 5 | 6.3 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| 57399670 | 69199 | 0 | None | 13 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934253 | 69199 | 0 | None | 13 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| 11386138 | 84006 | 0 | None | -8 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL221998 | 84006 | 0 | None | -8 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 16102899 | 83914 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 480 | 5 | 2 | 2 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F | 10.1021/jm061094b | ||
| CHEMBL221695 | 83914 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 480 | 5 | 2 | 2 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F | 10.1021/jm061094b | ||
| 57390411 | 69716 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 497 | 5 | 2 | 6 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC3(OCCO3)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939772 | 69716 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 497 | 5 | 2 | 6 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCC3(OCCO3)c3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 46230458 | 197530 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 6 | 2 | 8 | 4.6 | CC(=O)Nc1nonc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL589899 | 197530 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 6 | 2 | 8 | 4.6 | CC(=O)Nc1nonc1NCc1ccc(-c2cc(Cl)cc(F)c2-c2noc(C)n2)cc1F | 10.1016/j.bmcl.2009.11.120 | ||
| 11326315 | 149497 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 374 | 4 | 3 | 3 | 4.2 | O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Cl)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL395055 | 149497 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 374 | 4 | 3 | 3 | 4.2 | O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Cl)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44410084 | 76562 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 591 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL207033 | 76562 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 591 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 60143098 | 125398 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 428 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648492 | 125398 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 428 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 | nan | ||
| 23630614 | 141566 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 620 | 9 | 2 | 6 | 6.0 | O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1Cc1ccccc1)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL388270 | 141566 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 620 | 9 | 2 | 6 | 6.0 | O=C(Nc1c(Br)c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn1Cc1ccccc1)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44579944 | 186205 | 0 | None | - | 1 | Crab-eating macaque | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 494 | 8 | 1 | 7 | 3.8 | Cc1nc(-c2ccc(CN(C)C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)cc2)no1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL489192 | 186205 | 0 | None | - | 1 | Crab-eating macaque | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 494 | 8 | 1 | 7 | 3.8 | Cc1nc(-c2ccc(CN(C)C(=O)CNC(=O)c3nc4ccccc4n3Cc3ccccc3)cc2)no1 | 10.1016/j.bmcl.2008.08.014 | ||
| 57400697 | 69712 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 5 | 2 | 5 | 2.0 | CC(=O)N1CCC(NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)c2ccccc21 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939769 | 69712 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 5 | 2 | 5 | 2.0 | CC(=O)N1CCC(NC(=O)C[C@@H]2C(=O)NC=CN2S(=O)(=O)c2ccc(C)cc2)c2ccccc21 | 10.1016/j.bmcl.2011.11.112 | ||
| 44410316 | 140319 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381964 | 140319 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11691896 | 186113 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL488512 | 186113 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 44580046 | 183656 | 0 | None | - | 1 | Crab-eating macaque | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 438 | 7 | 3 | 5 | 3.7 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2nc[nH]c2c1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL483653 | 183656 | 0 | None | - | 1 | Crab-eating macaque | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 438 | 7 | 3 | 5 | 3.7 | O=C(CCNC(=O)c1nc2ccccc2n1Cc1ccccc1)Nc1ccc2nc[nH]c2c1 | 10.1016/j.bmcl.2008.08.014 | ||
| 60142025 | 125357 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 536 | 7 | 2 | 3 | 5.6 | O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| CHEMBL3648452 | 125357 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 536 | 7 | 2 | 3 | 5.6 | O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| 57403174 | 69202 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934256 | 69202 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 49863235 | 15046 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 613 | 10 | 3 | 4 | 6.7 | C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210752 | 15046 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 613 | 10 | 3 | 4 | 6.7 | C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 11421944 | 85106 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227778 | 85106 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 11555599 | 173018 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453338 | 173018 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 11526655 | 185975 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL487823 | 185975 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57398013 | 69203 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cc(Cl)ccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934257 | 69203 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cc(Cl)ccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 57402467 | 69708 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 2.5 | COc1ccc2c(c1)CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939765 | 69708 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 2.5 | COc1ccc2c(c1)CCCC2NC(=O)C[C@@H]1C(=O)NC=CN1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 23627520 | 73492 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 4.7 | COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018870 | 73492 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 4.7 | COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 44410273 | 76347 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206541 | 76347 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11259614 | 92820 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 455 | 6 | 3 | 4 | 2.7 | CC[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N(C)C | 10.1021/jm051292n | ||
| CHEMBL244935 | 92820 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 455 | 6 | 3 | 4 | 2.7 | CC[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)C(=O)N(C)C | 10.1021/jm051292n | ||
| 60142168 | 125364 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 550 | 7 | 2 | 3 | 6.0 | O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| CHEMBL3648459 | 125364 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 550 | 7 | 2 | 3 | 6.0 | O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| 56951319 | 69729 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 392 | 5 | 3 | 5 | 0.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNCC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939927 | 69729 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 392 | 5 | 3 | 5 | 0.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCNCC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57395449 | 69705 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 413 | 6 | 2 | 4 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H](C)c2ccccc2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939762 | 69705 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 413 | 6 | 2 | 4 | 2.2 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@H](C)c2ccccc2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 11584184 | 172533 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 500 | 8 | 3 | 6 | 2.7 | Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL452057 | 172533 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 500 | 8 | 3 | 6 | 2.7 | Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 46230310 | 198511 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 569 | 8 | 2 | 10 | 5.5 | COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc(C)c2C)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| CHEMBL596717 | 198511 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 569 | 8 | 2 | 10 | 5.5 | COc1cc(C(=O)Nn2c(NCc3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)nc(C)c2C)on1 | 10.1016/j.bmcl.2009.11.120 | ||
| 11555433 | 188392 | 0 | None | -2 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 520 | 8 | 3 | 6 | 3.0 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL508632 | 188392 | 0 | None | -2 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 520 | 8 | 3 | 6 | 3.0 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 9804704 | 92819 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 467 | 6 | 3 | 4 | 3.5 | CN1CCC(CCNC(=O)c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)CC1 | 10.1021/jm051292n | ||
| CHEMBL244934 | 92819 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 467 | 6 | 3 | 4 | 3.5 | CN1CCC(CCNC(=O)c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)CC1 | 10.1021/jm051292n | ||
| 11467345 | 161390 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL415629 | 161390 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 49863228 | 15036 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 639 | 10 | 2 | 4 | 6.8 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210742 | 15036 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 639 | 10 | 2 | 4 | 6.8 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 | 10.1016/j.bmcl.2010.06.010 | ||
| 44579915 | 183607 | 0 | None | - | 1 | Crab-eating macaque | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 514 | 5 | 0 | 6 | 2.9 | CN1CCC(N2CCN(C(=O)[C@@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL483241 | 183607 | 0 | None | - | 1 | Crab-eating macaque | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 514 | 5 | 0 | 6 | 2.9 | CN1CCC(N2CCN(C(=O)[C@@H]3CCCN3C(=O)c3nc4ccccc4n3Cc3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.08.014 | ||
| 16102920 | 82783 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 500 | 7 | 2 | 4 | 4.7 | CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL218553 | 82783 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 500 | 7 | 2 | 4 | 4.7 | CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 23630512 | 92109 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 466 | 7 | 3 | 5 | 4.1 | Cc1c(C(=O)NCCC2CCN(c3ccncc3)CC2)n[nH]c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL243208 | 92109 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 466 | 7 | 3 | 5 | 4.1 | Cc1c(C(=O)NCCC2CCN(c3ccncc3)CC2)n[nH]c1NC(=O)c1ccccc1Cl | 10.1021/jm051292n | ||
| 16221283 | 85093 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.9 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL227655 | 85093 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.9 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 16221109 | 143503 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 607 | 9 | 3 | 5 | 6.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL390311 | 143503 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 607 | 9 | 3 | 5 | 6.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 11387915 | 15038 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 611 | 10 | 2 | 4 | 6.4 | C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210744 | 15038 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 611 | 10 | 2 | 4 | 6.4 | C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 16221055 | 142204 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 607 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL389249 | 142204 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 607 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 11685446 | 186112 | 0 | None | 14 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL488501 | 186112 | 0 | None | 14 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2008.07.108 | ||
| 57395450 | 69706 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 425 | 5 | 2 | 4 | 2.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939763 | 69706 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 425 | 5 | 2 | 4 | 2.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44410026 | 76428 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 567 | 7 | 2 | 5 | 5.2 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206901 | 76428 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 567 | 7 | 2 | 5 | 5.2 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 60142833 | 125388 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 444 | 4 | 2 | 5 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648482 | 125388 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 444 | 4 | 2 | 5 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| 57400937 | 69714 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 454 | 5 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CC(=O)Nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939770 | 69714 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 454 | 5 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CC(=O)Nc3ccccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 16221162 | 143779 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 611 | 9 | 2 | 5 | 6.7 | CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL390540 | 143779 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 611 | 9 | 2 | 5 | 6.7 | CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 44410368 | 76393 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 553 | 7 | 2 | 5 | 4.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206801 | 76393 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 553 | 7 | 2 | 5 | 4.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 24946437 | 186182 | 0 | None | - | 1 | Crab-eating macaque | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 468 | 7 | 1 | 6 | 2.9 | O=C(NCCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL488983 | 186182 | 0 | None | - | 1 | Crab-eating macaque | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 468 | 7 | 1 | 6 | 2.9 | O=C(NCCC(=O)N1CCN(c2ccncc2)CC1)c1nc2ccccc2n1Cc1ccccc1 | 10.1016/j.bmcl.2008.08.014 | ||
| 11605512 | 173021 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 486 | 8 | 3 | 6 | 2.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453340 | 173021 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 486 | 8 | 3 | 6 | 2.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57401425 | 69205 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934259 | 69205 | 0 | None | 1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 57399670 | 69199 | 0 | None | -13 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934253 | 69199 | 0 | None | -13 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| 54586518 | 61846 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 552 | 7 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777963 | 61846 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 552 | 7 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 642 | 2266 | 17 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01011 | ||||
| CHEMBL384721 | 2266 | 17 | None | 2 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01011 | ||||
| 57394682 | 69724 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 391 | 5 | 2 | 4 | 1.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939922 | 69724 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 391 | 5 | 2 | 4 | 1.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2CCCCC2)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44354176 | 96294 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 925 | 28 | 10 | 10 | 0.6 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL264517 | 96294 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 925 | 28 | 10 | 10 | 0.6 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 44354059 | 116545 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 925 | 34 | 11 | 10 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O | 10.1021/jm980495r | ||
| CHEMBL339159 | 116545 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 925 | 34 | 11 | 10 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O | 10.1021/jm980495r | ||
| 44354039 | 114704 | 0 | None | - | 0 | Rat | 6.0 | pKd | = | 6 | Functional | ChEMBL | 883 | 27 | 9 | 10 | 1.3 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL334538 | 114704 | 0 | None | - | 0 | Rat | 6.0 | pKd | = | 6 | Functional | ChEMBL | 883 | 27 | 9 | 10 | 1.3 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 44354174 | 141015 | 0 | None | - | 0 | Rat | 5.0 | pKd | = | 5 | Functional | ChEMBL | 1081 | 35 | 14 | 12 | -1.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(=O)O | 10.1021/jm980495r | ||
| CHEMBL384846 | 141015 | 0 | None | - | 0 | Rat | 5.0 | pKd | = | 5 | Functional | ChEMBL | 1081 | 35 | 14 | 12 | -1.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(=O)O | 10.1021/jm980495r | ||
| CHEMBL133560 | 206968 | 0 | None | - | 0 | Rat | 5.0 | pKd | = | 5 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCC1 | 10.1021/jm980495r | ||||
| CHEMBL339389 | 209865 | 0 | None | - | 0 | Rat | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 | 10.1021/jm980495r | ||||
| 56668285 | 62973 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1145 | 26 | 13 | 15 | -1.1 | C=C([C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)CC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL1793829 | 62973 | 0 | None | - | 0 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1145 | 26 | 13 | 15 | -1.1 | C=C([C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)CC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL2370699 | 208160 | 4 | None | - | 0 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C1Cc2ccccc2C1)C(=O)O | 10.1021/jm980495r | ||||
| 44354162 | 24184 | 0 | None | - | 0 | Rat | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 840 | 22 | 10 | 10 | -1.7 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL134135 | 24184 | 0 | None | - | 0 | Rat | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 840 | 22 | 10 | 10 | -1.7 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 44354032 | 155194 | 0 | None | - | 0 | Rat | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 1037 | 26 | 12 | 12 | -1.4 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCC(=O)NC1(C(=O)NCCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 | 10.1021/jm980495r | ||
| CHEMBL405644 | 155194 | 0 | None | - | 0 | Rat | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 1037 | 26 | 12 | 12 | -1.4 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCC(=O)NC1(C(=O)NCCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 | 10.1021/jm980495r | ||
| 44354038 | 19640 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 925 | 28 | 9 | 10 | 1.5 | CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL130222 | 19640 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 925 | 28 | 9 | 10 | 1.5 | CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 44354033 | 96583 | 0 | None | - | 0 | Rat | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 1009 | 24 | 12 | 12 | -2.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCC(=O)NC1(C(=O)NCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 | 10.1021/jm980495r | ||
| CHEMBL266975 | 96583 | 0 | None | - | 0 | Rat | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 1009 | 24 | 12 | 12 | -2.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCC(=O)NC1(C(=O)NCCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 | 10.1021/jm980495r | ||
| CHEMBL131647 | 206940 | 0 | None | - | 0 | Rat | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCCC1 | 10.1021/jm980495r | ||||
| 16108961 | 908 | 0 | None | 2 | 3 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 664 | 908 | 0 | None | 2 | 3 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| CHEMBL415848 | 908 | 0 | None | 2 | 3 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 44354214 | 114996 | 0 | None | - | 0 | Rat | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 869 | 24 | 10 | 10 | -1.0 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL335247 | 114996 | 0 | None | - | 0 | Rat | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 869 | 24 | 10 | 10 | -1.0 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 44354175 | 96447 | 0 | None | - | 0 | Rat | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 1025 | 35 | 12 | 12 | 0.8 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@@H]1C(=O)O)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| CHEMBL265814 | 96447 | 0 | None | - | 0 | Rat | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 1025 | 35 | 12 | 12 | 0.8 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@@H]1C(=O)O)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| 44354187 | 116287 | 0 | None | - | 0 | Rat | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 925 | 29 | 11 | 10 | 0.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)O)C[C@H]2CCCC[C@H]21)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| CHEMBL337833 | 116287 | 0 | None | - | 0 | Rat | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 925 | 29 | 11 | 10 | 0.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)O)C[C@H]2CCCC[C@H]21)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| CHEMBL410363 | 211059 | 17 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O | 10.1021/jm980495r | ||||
| CHEMBL133164 | 206961 | 0 | None | - | 0 | Rat | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NC1(C(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCCCC1 | 10.1021/jm980495r | ||||
| CHEMBL218454 | 207642 | 0 | None | - | 0 | Rat | 5.2 | pKd | = | 5.2 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCC(=O)NC1(C(=O)NCC(=O)N[C@@H](CO)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2[C@H](C(=O)O)C[C@@H]3CCCC[C@@H]32)CCCCCC1 | 10.1021/jm980495r | ||||
| CHEMBL2370700 | 208161 | 0 | None | - | 0 | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | None | None | None | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C1Cc2ccccc2C1)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||||
| 44354179 | 165031 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 911 | 27 | 10 | 10 | 0.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL424272 | 165031 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 911 | 27 | 10 | 10 | 0.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 44354239 | 141057 | 0 | None | - | 0 | Rat | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 1011 | 33 | 11 | 12 | 0.9 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL385081 | 141057 | 0 | None | - | 0 | Rat | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 1011 | 33 | 11 | 12 | 0.9 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 11620871 | 165471 | 0 | None | - | 0 | Human | 10.4 | pKi | = | 10.4 | Functional | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1021/jm200371q | ||
| CHEMBL425588 | 165471 | 0 | None | - | 0 | Human | 10.4 | pKi | = | 10.4 | Functional | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1021/jm200371q | ||
| 53248885 | 61841 | 0 | None | 18 | 2 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1021/jm200808v | ||
| CHEMBL1777958 | 61841 | 0 | None | 18 | 2 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1021/jm200808v | ||
| 11342704 | 61839 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 642 | 7 | 2 | 6 | 4.2 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777956 | 61839 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 642 | 7 | 2 | 6 | 4.2 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1sc(Cl)cc1Br)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 11215677 | 61840 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 614 | 7 | 2 | 6 | 4.6 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777957 | 61840 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 614 | 7 | 2 | 6 | 4.6 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cc2cc(Cl)ccc2s1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 44587187 | 188115 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL504531 | 188115 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54582655 | 61852 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Functional | ChEMBL | 552 | 7 | 2 | 5 | 3.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777969 | 61852 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Functional | ChEMBL | 552 | 7 | 2 | 5 | 3.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCC(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 25195622 | 61838 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Functional | ChEMBL | 606 | 7 | 2 | 5 | 4.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777955 | 61838 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Functional | ChEMBL | 606 | 7 | 2 | 5 | 4.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2011.03.115 | ||
| 11215488 | 61837 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777954 | 61837 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 53248885 | 61841 | 0 | None | 18 | 2 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777958 | 61841 | 0 | None | 18 | 2 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 54580628 | 61827 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777879 | 61827 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54583617 | 61851 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 2.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777968 | 61851 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 2.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 54581634 | 61832 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777884 | 61832 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 4.1 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54586519 | 61860 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 524 | 9 | 3 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777977 | 61860 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 524 | 9 | 3 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 11341479 | 61861 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 526 | 9 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777978 | 61861 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 526 | 9 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594769 | 65380 | 0 | None | 6 | 2 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834619 | 65380 | 0 | None | 6 | 2 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 11214819 | 61833 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777885 | 61833 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 11387387 | 61850 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777967 | 61850 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 16221282 | 85098 | 0 | None | 13 | 2 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL227713 | 85098 | 0 | None | 13 | 2 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 11168954 | 61830 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777882 | 61830 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1Cl)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 11342350 | 61835 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777887 | 61835 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 592 | 7 | 2 | 5 | 3.8 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(C(F)(F)F)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54587552 | 61849 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777966 | 61849 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(C[C@@H]1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54581667 | 61858 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 538 | 8 | 3 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777975 | 61858 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 538 | 8 | 3 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 54581635 | 61834 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 554 | 8 | 2 | 6 | 2.8 | COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777886 | 61834 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 554 | 8 | 2 | 6 | 2.8 | COc1ccc(S(=O)(=O)N2CCNC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56589598 | 65436 | 0 | None | 7 | 2 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 543 | 5 | 1 | 6 | 5.2 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| CHEMBL1834751 | 65436 | 0 | None | 7 | 2 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 543 | 5 | 1 | 6 | 5.2 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| 54772237 | 65437 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 525 | 5 | 1 | 6 | 5.0 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834752 | 65437 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 525 | 5 | 1 | 6 | 5.0 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cn2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| 54587514 | 61831 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777883 | 61831 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 558 | 7 | 2 | 5 | 3.4 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccc(Cl)cc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594642 | 65377 | 0 | None | 21 | 2 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834616 | 65377 | 0 | None | 21 | 2 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 9894973 | 101275 | 0 | None | - | 0 | Rat | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL299832 | 101275 | 0 | None | - | 0 | Rat | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1016/j.bmcl.2008.08.014 | ||
| 54582656 | 61857 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 510 | 8 | 3 | 5 | 2.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777974 | 61857 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 510 | 8 | 3 | 5 | 2.3 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 11364466 | 61829 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777881 | 61829 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 524 | 7 | 2 | 5 | 2.7 | O=C(CC1C(=O)NCCN1S(=O)(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54587553 | 61862 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 540 | 8 | 3 | 5 | 3.2 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777979 | 61862 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 540 | 8 | 3 | 5 | 3.2 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594640 | 65375 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 524 | 5 | 1 | 5 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834614 | 65375 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 524 | 5 | 1 | 5 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)cccc12 | 10.1021/jm200808v | ||
| 54581666 | 61853 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777970 | 61853 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC(C)(C)C4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 10388673 | 71044 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 443 | 7 | 2 | 5 | 5.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1021/jm1013693 | ||
| CHEMBL195883 | 71044 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 443 | 7 | 2 | 5 | 5.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1021/jm1013693 | ||
| 16221282 | 85098 | 0 | None | - | 2 | Rat | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227713 | 85098 | 0 | None | - | 2 | Rat | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| 16221108 | 85092 | 0 | None | - | 2 | Rat | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227600 | 85092 | 0 | None | - | 2 | Rat | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| 56594371 | 65535 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 508 | 5 | 1 | 4 | 6.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2csc3ccccc3c2=O)c1 | 10.1021/jm200808v | ||
| CHEMBL1835760 | 65535 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 508 | 5 | 1 | 4 | 6.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2csc3ccccc3c2=O)c1 | 10.1021/jm200808v | ||
| 16102897 | 86797 | 13 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL232943 | 86797 | 13 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2008.08.014 | ||
| 56672397 | 65527 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 432 | 9 | 1 | 3 | 5.6 | O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm200808v | ||
| CHEMBL1835752 | 65527 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 432 | 9 | 1 | 3 | 5.6 | O=C(CCCCC(=O)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm200808v | ||
| 54580655 | 61845 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.8 | Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777962 | 61845 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 566 | 7 | 2 | 5 | 3.8 | Cc1ccc(S(=O)(=O)N2CC(C)(C)NC(=O)C2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594372 | 65536 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 508 | 5 | 1 | 4 | 6.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2csc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| CHEMBL1835761 | 65536 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 508 | 5 | 1 | 4 | 6.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2csc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| 56594242 | 65532 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| CHEMBL1835757 | 65532 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| 44569935 | 168914 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 646 | 13 | 1 | 6 | 5.3 | CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL443207 | 168914 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 646 | 13 | 1 | 6 | 5.3 | CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 56594643 | 65378 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cc(Cl)ccc12 | 10.1021/jm200808v | ||
| CHEMBL1834617 | 65378 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cc(Cl)ccc12 | 10.1021/jm200808v | ||
| 11284304 | 61855 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 553 | 7 | 2 | 6 | 1.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777972 | 61855 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 553 | 7 | 2 | 6 | 1.8 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCN(C)CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594772 | 65435 | 0 | None | 15 | 2 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 542 | 5 | 1 | 6 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834750 | 65435 | 0 | None | 15 | 2 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 542 | 5 | 1 | 6 | 5.6 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCOc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 16221056 | 85120 | 0 | None | - | 2 | Rat | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL227870 | 85120 | 0 | None | - | 2 | Rat | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 56594507 | 65542 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 534 | 6 | 1 | 5 | 6.3 | CC(C)c1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| CHEMBL1835768 | 65542 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 534 | 6 | 1 | 5 | 6.3 | CC(C)c1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| 11284458 | 140045 | 2 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL381366 | 140045 | 2 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44569936 | 172604 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 627 | 14 | 1 | 6 | 5.9 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL452238 | 172604 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 627 | 14 | 1 | 6 | 5.9 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 56594506 | 65541 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 520 | 6 | 1 | 5 | 5.7 | CCc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| CHEMBL1835767 | 65541 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 520 | 6 | 1 | 5 | 5.7 | CCc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| 56658544 | 65528 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 466 | 7 | 1 | 3 | 5.9 | O=C(Cc1ccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1)c1ccccc1 | 10.1021/jm200808v | ||
| CHEMBL1835753 | 65528 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 466 | 7 | 1 | 3 | 5.9 | O=C(Cc1ccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1)c1ccccc1 | 10.1021/jm200808v | ||
| 11272685 | 61854 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 1.9 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777971 | 61854 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 540 | 7 | 2 | 6 | 1.9 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCOCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594770 | 65382 | 0 | None | 7 | 2 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| CHEMBL1834620 | 65382 | 0 | None | 7 | 2 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 541 | 5 | 1 | 6 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)nc2)c(=O)c2c(Cl)cccc12 | 10.1021/jm200808v | ||
| 56594641 | 65376 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 542 | 5 | 1 | 5 | 5.8 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| CHEMBL1834615 | 65376 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 542 | 5 | 1 | 5 | 5.8 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2c(F)ccc(F)c12 | 10.1021/jm200808v | ||
| 54587550 | 61842 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777959 | 61842 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56679097 | 65530 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 466 | 7 | 1 | 3 | 5.9 | O=C(Cc1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1)c1ccccc1 | 10.1021/jm200808v | ||
| CHEMBL1835755 | 65530 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 466 | 7 | 1 | 3 | 5.9 | O=C(Cc1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1)c1ccccc1 | 10.1021/jm200808v | ||
| 56594243 | 65533 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 505 | 5 | 1 | 4 | 6.0 | Cn1cc(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc21 | 10.1021/jm200808v | ||
| CHEMBL1835758 | 65533 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 505 | 5 | 1 | 4 | 6.0 | Cn1cc(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc21 | 10.1021/jm200808v | ||
| 56594374 | 65538 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| CHEMBL1835763 | 65538 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| 11495796 | 73173 | 0 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 436 | 7 | 2 | 4 | 3.6 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 | 10.1021/jm1013693 | ||
| CHEMBL201717 | 73173 | 0 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 436 | 7 | 2 | 4 | 3.6 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 | 10.1021/jm1013693 | ||
| 25181410 | 171638 | 1 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL447392 | 171638 | 1 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 11635365 | 173979 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1021/jm200808v | ||
| CHEMBL455642 | 173979 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1021/jm200808v | ||
| 54585540 | 61859 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 526 | 7 | 3 | 5 | 3.0 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777976 | 61859 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 526 | 7 | 3 | 5 | 3.0 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594768 | 65379 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccc(Cl)cc12 | 10.1021/jm200808v | ||
| CHEMBL1834618 | 65379 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 540 | 5 | 1 | 5 | 6.1 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccc(Cl)cc12 | 10.1021/jm200808v | ||
| 56594639 | 65374 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 568 | 6 | 1 | 5 | 6.8 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(-c3ccccc3)c3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| CHEMBL1834613 | 65374 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 568 | 6 | 1 | 5 | 6.8 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(-c3ccccc3)c3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| 54586518 | 61846 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 552 | 7 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777963 | 61846 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 552 | 7 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCN(C)C(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44569938 | 188302 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 629 | 14 | 1 | 7 | 4.7 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL507546 | 188302 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 629 | 14 | 1 | 7 | 4.7 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 25181411 | 188694 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 587 | 14 | 1 | 6 | 5.0 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL512111 | 188694 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 587 | 14 | 1 | 6 | 5.0 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 54584600 | 61848 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777965 | 61848 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CC(=O)NCC2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 54581664 | 61843 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777960 | 61843 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594505 | 65540 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 492 | 5 | 1 | 5 | 5.2 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2ncc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| CHEMBL1835766 | 65540 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 492 | 5 | 1 | 5 | 5.2 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2ncc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| 54583583 | 61828 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 462 | 6 | 2 | 5 | 1.3 | CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777880 | 61828 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 462 | 6 | 2 | 5 | 1.3 | CS(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2011.03.115 | ||
| 54587551 | 61844 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777961 | 61844 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@@H]2CC(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56668920 | 65529 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 466 | 7 | 1 | 3 | 5.9 | O=C(Cc1ccccc1)c1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1 | 10.1021/jm200808v | ||
| CHEMBL1835754 | 65529 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 466 | 7 | 1 | 3 | 5.9 | O=C(Cc1ccccc1)c1cccc(C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)c1 | 10.1021/jm200808v | ||
| 54585539 | 61856 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777973 | 61856 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 56594504 | 65539 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 492 | 5 | 1 | 5 | 5.2 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2cnc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| CHEMBL1835765 | 65539 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 492 | 5 | 1 | 5 | 5.2 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2cnc3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| 11546560 | 73573 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 434 | 7 | 2 | 4 | 3.4 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 | 10.1021/jm1013693 | ||
| CHEMBL202089 | 73573 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 434 | 7 | 2 | 4 | 3.4 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 | 10.1021/jm1013693 | ||
| 56594373 | 65537 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| CHEMBL1835762 | 65537 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 | 10.1021/jm200808v | ||
| 56594241 | 65531 | 0 | None | 4 | 2 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1021/jm200808v | ||
| CHEMBL1835756 | 65531 | 0 | None | 4 | 2 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1021/jm200808v | ||
| 56594771 | 65434 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 507 | 5 | 1 | 6 | 4.9 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 | 10.1021/jm200808v | ||
| CHEMBL1834749 | 65434 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 507 | 5 | 1 | 6 | 4.9 | Cc1nn(-c2ccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2cccnc12 | 10.1021/jm200808v | ||
| 54581665 | 61847 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 552 | 7 | 2 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2(C)CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| CHEMBL1777964 | 61847 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 552 | 7 | 2 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCNC(=O)C2(C)CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.03.115 | ||
| 44411297 | 76993 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 | 10.1021/jm200371q | ||
| CHEMBL208538 | 76993 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 354 | 5 | 1 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 | 10.1021/jm200371q | ||
| 56594508 | 65543 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 560 | 5 | 1 | 5 | 6.2 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(C(F)(F)F)c3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| CHEMBL1835769 | 65543 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 560 | 5 | 1 | 5 | 6.2 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-n2nc(C(F)(F)F)c3ccccc3c2=O)cc1 | 10.1021/jm200808v | ||
| 653 | 559 | 0 | None | -199 | 3 | Mouse | 6.1 | pA2 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 123884 | 2264 | 13 | None | - | 1 | Mouse | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8834490 | ||||
| 641 | 2264 | 13 | None | - | 1 | Mouse | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8834490 | ||||
| CHEMBL80472 | 2264 | 13 | None | - | 1 | Mouse | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8834490 | ||||
| 642 | 2266 | 17 | None | -2 | 2 | Mouse | 7.0 | pA2 | = | 7 | Functional | Guide to Pharmacology | None | None | None | None | 8834490 | ||||
| CHEMBL384721 | 2266 | 17 | None | -2 | 2 | Mouse | 7.0 | pA2 | = | 7 | Functional | Guide to Pharmacology | None | None | None | None | 8834490 | ||||
| 661 | 3215 | 0 | None | -31 | 2 | Mouse | 7.0 | pA2 | = | 7 | Functional | Guide to Pharmacology | None | None | None | None | 8834490 | ||||
| 663 | 1345 | 0 | None | - | 1 | Mouse | 7.2 | pA2 | = | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 653 | 559 | 0 | None | -5 | 3 | Human | 7.7 | pA2 | = | 7.7 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 661 | 3215 | 0 | None | 31 | 2 | Human | 8.5 | pA2 | = | 8.5 | Functional | Guide to Pharmacology | None | None | None | None | 8901831 | ||||
| 101865250 | 3216 | 0 | None | - | 1 | Human | 8.6 | pA2 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | NCCC[C@@H](C(=O)N[C@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H]([C@H](CC)C)C(=O)O)Cc1ccc2c(c1)cccc2)CO)(Cc1ccccc1)C)CCCN=C(N)N)NC(=O)C | 24361511 | ||||
| 3906 | 3216 | 0 | None | - | 1 | Human | 8.6 | pA2 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | NCCC[C@@H](C(=O)N[C@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H]([C@H](CC)C)C(=O)O)Cc1ccc2c(c1)cccc2)CO)(Cc1ccccc1)C)CCCN=C(N)N)NC(=O)C | 24361511 | ||||
| 654 | 560 | 0 | None | - | 1 | Human | 9.2 | pA2 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 123884 | 2264 | 13 | None | - | 1 | Mouse | 7.3 | pEC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 641 | 2264 | 13 | None | - | 1 | Mouse | 7.3 | pEC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| CHEMBL80472 | 2264 | 13 | None | - | 1 | Mouse | 7.3 | pEC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 642 | 2266 | 17 | None | 2 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 8063797 | ||||
| CHEMBL384721 | 2266 | 17 | None | 2 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 8063797 | ||||
| 10254 | 2765 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 26565554 | ||||
| 3035449 | 2470 | 0 | None | -39 | 3 | Human | 7.1 | pIC50 | None | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 8063797 | ||||
| 638 | 2470 | 0 | None | -39 | 3 | Human | 7.1 | pIC50 | None | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 8063797 | ||||
| 16108961 | 908 | 0 | None | -2 | 3 | Rat | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 17243660 | ||
| 664 | 908 | 0 | None | -2 | 3 | Rat | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 17243660 | ||
| CHEMBL415848 | 908 | 0 | None | -2 | 3 | Rat | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 17243660 | ||
| 16108961 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | None | 8.5 | Functional | Guide to Pharmacology | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 17243660 | ||
| 664 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | None | 8.5 | Functional | Guide to Pharmacology | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 17243660 | ||
| CHEMBL415848 | 908 | 0 | None | 2 | 3 | Human | 8.5 | pIC50 | None | 8.5 | Functional | Guide to Pharmacology | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 17243660 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 665 | 957 | 2 | None | - | 2 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 9916412 | 957 | 2 | None | - | 2 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| CHEMBL189123 | 957 | 2 | None | - | 2 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 122227 | 1346 | 27 | None | 6 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 3825 | 1346 | 27 | None | 6 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 644 | 1346 | 27 | None | 6 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| CHEMBL264100 | 1346 | 27 | None | 6 | 3 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 44579694 | 192531 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 486 | 7 | 3 | 5 | 3.6 | Cc1c(C(=O)NCCC2CCN(C3CCN(C)CC3)CC2)n[nH]c1NC(=O)c1ccccc1Cl | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL522947 | 192531 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 486 | 7 | 3 | 5 | 3.6 | Cc1c(C(=O)NCCC2CCN(C3CCN(C)CC3)CC2)n[nH]c1NC(=O)c1ccccc1Cl | 10.1016/j.bmcl.2008.08.014 | ||
| 10031511 | 16750 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1253497 | 16750 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 11204003 | 76853 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 579 | 7 | 2 | 4 | 6.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL207947 | 76853 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 579 | 7 | 2 | 4 | 6.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1C(F)(F)F | 10.1016/j.bmcl.2006.01.069 | ||
| 44410020 | 137679 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 549 | 7 | 1 | 4 | 5.0 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL377011 | 137679 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 549 | 7 | 1 | 4 | 5.0 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CN3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410316 | 140319 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381964 | 140319 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410269 | 165570 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 569 | 11 | 2 | 5 | 5.9 | CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL426130 | 165570 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 569 | 11 | 2 | 5 | 5.9 | CCCCOc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11215189 | 168217 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 9 | 2 | 4 | 5.6 | CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL437509 | 168217 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 9 | 2 | 4 | 5.6 | CC(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11444270 | 76351 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 553 | 7 | 2 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206554 | 76351 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 553 | 7 | 2 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1csc2ccccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 11444165 | 140335 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 5.7 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381979 | 140335 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 5.7 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1Cl | 10.1016/j.bmcl.2006.01.069 | ||
| 11512379 | 165441 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 7 | 2 | 7 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL425416 | 165441 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 7 | 2 | 7 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2nsnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410368 | 76393 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 553 | 7 | 2 | 5 | 4.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206801 | 76393 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 553 | 7 | 2 | 5 | 4.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11203826 | 139579 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 9 | 2 | 4 | 5.3 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL380117 | 139579 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 9 | 2 | 4 | 5.3 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410026 | 76428 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 567 | 7 | 2 | 5 | 5.2 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206901 | 76428 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 567 | 7 | 2 | 5 | 5.2 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 665 | 957 | 2 | None | -1023 | 2 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 9916412 | 957 | 2 | None | -1023 | 2 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| CHEMBL189123 | 957 | 2 | None | -1023 | 2 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 10187347 | 192747 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 544 | 7 | 2 | 5 | 5.5 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL52498 | 192747 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 544 | 7 | 2 | 5 | 5.5 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 44410143 | 76968 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 497 | 7 | 2 | 4 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL208386 | 76968 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 497 | 7 | 2 | 4 | 4.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410084 | 76562 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 591 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL207033 | 76562 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 591 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNCC(F)(F)F)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 10031511 | 16750 | 0 | None | -1 | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1253497 | 16750 | 0 | None | -1 | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 10031511 | 16750 | 0 | None | -1 | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| CHEMBL1253497 | 16750 | 0 | None | -1 | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| 11478613 | 140048 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 567 | 10 | 2 | 5 | 4.6 | COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381372 | 140048 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 567 | 10 | 2 | 5 | 4.6 | COCCNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410250 | 75587 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205227 | 75587 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cccnc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 10875606 | 62729 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1788318 | 62729 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 11284458 | 140045 | 2 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL381366 | 140045 | 2 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11017305 | 59993 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744084 | 59993 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 11071992 | 59991 | 0 | None | 3 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744082 | 59991 | 0 | None | 3 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 11039234 | 59994 | 0 | None | -1 | 2 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744085 | 59994 | 0 | None | -1 | 2 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| 44455075 | 94895 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 482 | 5 | 2 | 5 | 4.5 | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL256671 | 94895 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 482 | 5 | 2 | 5 | 4.5 | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44410186 | 76849 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 615 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL207945 | 76849 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 615 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 16726096 | 154717 | 7 | None | 2 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402831 | 154717 | 7 | None | 2 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| 11050306 | 59992 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744083 | 59992 | 0 | None | 1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 44455035 | 95267 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 490 | 5 | 2 | 7 | 3.4 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL258324 | 95267 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 490 | 5 | 2 | 7 | 3.4 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.11.050 | ||
| 44455108 | 154593 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402114 | 154593 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 11330286 | 76102 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 8 | 2 | 4 | 5.1 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205981 | 76102 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 8 | 2 | 4 | 5.1 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410273 | 76347 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206541 | 76347 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 531 | 7 | 2 | 4 | 5.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11238372 | 168463 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL439505 | 168463 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 8 | 2 | 4 | 5.5 | O=C(C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCCc2cc(CNC3CCC3)ccc21 | 10.1016/j.bmcl.2006.01.069 | ||
| 11071992 | 59991 | 0 | None | -3 | 2 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744082 | 59991 | 0 | None | -3 | 2 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 11307733 | 74532 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 579 | 8 | 2 | 4 | 6.0 | CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL203174 | 74532 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 579 | 8 | 2 | 4 | 6.0 | CC(C)(C)CNCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44455073 | 95129 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 506 | 5 | 2 | 6 | 5.0 | Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL257729 | 95129 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 506 | 5 | 2 | 6 | 5.0 | Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44455038 | 95268 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL258326 | 95268 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44410254 | 75590 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205242 | 75590 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 548 | 7 | 2 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc2cnccc12 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410328 | 75637 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 537 | 7 | 1 | 4 | 4.9 | CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL205501 | 75637 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 537 | 7 | 1 | 4 | 4.9 | CN(C)Cc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11284303 | 65995 | 0 | None | -2 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 553 | 15 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| CHEMBL185068 | 65995 | 0 | None | -2 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 553 | 15 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| 11039234 | 59994 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744085 | 59994 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| 44410179 | 165752 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL427208 | 165752 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 8 | 2 | 4 | 6.4 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11050306 | 59992 | 0 | None | -1 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744083 | 59992 | 0 | None | -1 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 11214998 | 76187 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 551 | 8 | 2 | 4 | 5.3 | CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL206247 | 76187 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 551 | 8 | 2 | 4 | 5.3 | CC(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.01.069 | ||
| 44410313 | 75434 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 527 | 8 | 2 | 5 | 4.7 | COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL204847 | 75434 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 527 | 8 | 2 | 5 | 4.7 | COc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11017305 | 59993 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744084 | 59993 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 11420875 | 76969 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 7 | 2 | 4 | 5.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| CHEMBL208387 | 76969 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 7 | 2 | 4 | 5.0 | Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2006.01.069 | ||
| 11757682 | 121513 | 0 | None | 2 | 4 | Human | 10.8 | pKd | = | 10.8 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL359553 | 121513 | 0 | None | 2 | 4 | Human | 10.8 | pKd | = | 10.8 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11444808 | 53656 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 601 | 8 | 3 | 6 | 4.1 | O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL160547 | 53656 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 601 | 8 | 3 | 6 | 4.1 | O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11757682 | 121513 | 0 | None | 2 | 4 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL359553 | 121513 | 0 | None | 2 | 4 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11757682 | 121513 | 0 | None | 2 | 4 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL359553 | 121513 | 0 | None | 2 | 4 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11319515 | 66381 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 615 | 8 | 2 | 6 | 4.5 | CN1CCN=C1c1ccc(CCNC(=O)C[C@@H]2C(=O)Nc3ccc(Cl)cc3N2S(=O)(=O)c2ccc3ccccc3c2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL185693 | 66381 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 615 | 8 | 2 | 6 | 4.5 | CN1CCN=C1c1ccc(CCNC(=O)C[C@@H]2C(=O)Nc3ccc(Cl)cc3N2S(=O)(=O)c2ccc3ccccc3c2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL3085458 | 209232 | 3 | None | 398 | 2 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||||
| CHEMBL3085458 | 209232 | 3 | None | 398 | 2 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990962k | ||||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2004.09.074 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2004.09.074 | ||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2012.03.065 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2012.03.065 | ||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2008.07.055 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2008.07.055 | ||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1021/jm1000776 | ||
| 90662943 | 106089 | 0 | None | 1778 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 1192 | 30 | 14 | 17 | -4.3 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| CHEMBL3142391 | 106089 | 0 | None | 1778 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 1192 | 30 | 14 | 17 | -4.3 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11620871 | 165471 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL425588 | 165471 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11570120 | 69698 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 536 | 7 | 2 | 5 | 3.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939755 | 69698 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 536 | 7 | 2 | 5 | 3.5 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11757682 | 121513 | 0 | None | -2 | 4 | Rabbit | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL359553 | 121513 | 0 | None | -2 | 4 | Rabbit | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11620871 | 165471 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL425588 | 165471 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11365433 | 66386 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 599 | 8 | 3 | 5 | 5.1 | O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL185727 | 66386 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 599 | 8 | 3 | 5 | 5.1 | O=C(C[C@@H]1C(=O)Nc2ccc(Cl)cc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11180561 | 66403 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 4.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL185811 | 66403 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 4.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(-c2ncc[nH]2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11620871 | 165471 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL425588 | 165471 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44587187 | 188115 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL504531 | 188115 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 640 | 7 | 2 | 5 | 6.1 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 10288906 | 135862 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 484 | 7 | 2 | 4 | 4.2 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL373530 | 135862 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 484 | 7 | 2 | 4 | 4.2 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 44587186 | 172139 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 642 | 7 | 2 | 6 | 5.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL450541 | 172139 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 642 | 7 | 2 | 6 | 5.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 53248885 | 61841 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1777958 | 61841 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 538 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 24970287 | 187829 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 574 | 7 | 2 | 6 | 4.2 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL502140 | 187829 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 574 | 7 | 2 | 6 | 4.2 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 57397292 | 69701 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 522 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939758 | 69701 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 522 | 7 | 2 | 5 | 3.1 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN4CCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 16041612 | 172389 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 499 | 8 | 2 | 7 | 4.0 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| CHEMBL451761 | 172389 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 499 | 8 | 2 | 7 | 4.0 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| 44455519 | 97406 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 542 | 8 | 2 | 3 | 5.8 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL272278 | 97406 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 542 | 8 | 2 | 3 | 5.8 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 11387624 | 159017 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 576 | 9 | 2 | 6 | 5.6 | C[C@@H](NC(=O)C1(NC(=O)c2cc(Cl)no2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL410281 | 159017 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 576 | 9 | 2 | 6 | 5.6 | C[C@@H](NC(=O)C1(NC(=O)c2cc(Cl)no2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 11352746 | 77158 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 510 | 10 | 0 | 7 | 1.6 | CCN1CCC(N2CCN(C(=O)COCCN(C)S(=O)(=O)c3c(C)cc(OC)cc3C)CC2)CC1 | 10.1021/jm2016057 | ||
| CHEMBL2087422 | 77158 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 510 | 10 | 0 | 7 | 1.6 | CCN1CCC(N2CCN(C(=O)COCCN(C)S(=O)(=O)c3c(C)cc(OC)cc3C)CC2)CC1 | 10.1021/jm2016057 | ||
| 44316161 | 160957 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1043 | 25 | 12 | 16 | -4.0 | NCCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O | 10.1021/jm990961s | ||
| CHEMBL412824 | 160957 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1043 | 25 | 12 | 16 | -4.0 | NCCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O | 10.1021/jm990961s | ||
| 122227 | 1346 | 27 | None | 6 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 3825 | 1346 | 27 | None | 6 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 644 | 1346 | 27 | None | 6 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| CHEMBL264100 | 1346 | 27 | None | 6 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 44587189 | 171865 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 588 | 7 | 2 | 6 | 4.5 | Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL447870 | 171865 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 588 | 7 | 2 | 6 | 4.5 | Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 16108969 | 82604 | 0 | None | 239883 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL218152 | 82604 | 0 | None | 239883 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 44587189 | 171865 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 588 | 7 | 2 | 6 | 4.5 | Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL447870 | 171865 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 588 | 7 | 2 | 6 | 4.5 | Cc1ccc(S(=O)(=O)N2c3ccccc3NC(=O)[C@H]2CC(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.055 | ||
| 16108969 | 82604 | 0 | None | 239883 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL218152 | 82604 | 0 | None | 239883 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 24895452 | 185707 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 520 | 10 | 3 | 5 | 4.7 | O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL487445 | 185707 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 520 | 10 | 3 | 5 | 4.7 | O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 24895452 | 185707 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 520 | 10 | 3 | 5 | 4.7 | O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm1000776 | ||
| CHEMBL487445 | 185707 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 520 | 10 | 3 | 5 | 4.7 | O=C(NCCCN1CCCCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm1000776 | ||
| 11848206 | 16901 | 45 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 500 | 3 | 0 | 4 | 5.4 | O=C(c1cccc(N2Cc3cccc(Cl)c3C2=O)c1)N1CCC2(CC1)CCN(c1ccncc1)CC2 | 10.1021/jm1000776 | ||
| CHEMBL1254945 | 16901 | 45 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 500 | 3 | 0 | 4 | 5.4 | O=C(c1cccc(N2Cc3cccc(Cl)c3C2=O)c1)N1CCC2(CC1)CCN(c1ccncc1)CC2 | 10.1021/jm1000776 | ||
| 11953367 | 16875 | 12 | None | 19 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL1254771 | 16875 | 12 | None | 19 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm2016057 | ||
| 44455075 | 94895 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 482 | 5 | 2 | 5 | 4.5 | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL256671 | 94895 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 482 | 5 | 2 | 5 | 4.5 | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 11953367 | 16875 | 12 | None | 19 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm1000776 | ||
| CHEMBL1254771 | 16875 | 12 | None | 19 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm1000776 | ||
| 44580744 | 187296 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 480 | 5 | 2 | 8 | 2.9 | C[C@@H](NC(=O)C1(O)CCSC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL496530 | 187296 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 480 | 5 | 2 | 8 | 2.9 | C[C@@H](NC(=O)C1(O)CCSC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 44430696 | 87510 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.1 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234096 | 87510 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.1 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 23628223 | 87493 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 520 | 6 | 2 | 4 | 5.0 | COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL233968 | 87493 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 520 | 6 | 2 | 4 | 5.0 | COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| 44455268 | 94752 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)c2ccno2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL255997 | 94752 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)c2ccno2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 44455087 | 155014 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 549 | 8 | 2 | 7 | 4.7 | COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(OC)no3)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL404370 | 155014 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 549 | 8 | 2 | 7 | 4.7 | COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(OC)no3)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| 16221282 | 85098 | 0 | None | 316 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227713 | 85098 | 0 | None | 316 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 619 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| 10173772 | 161310 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 452 | 7 | 2 | 4 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL414962 | 161310 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 452 | 7 | 2 | 4 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11283865 | 77170 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 523 | 10 | 0 | 6 | 3.3 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C(C)C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087434 | 77170 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 523 | 10 | 0 | 6 | 3.3 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C(C)C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 11442712 | 84788 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL225607 | 84788 | 0 | None | 1 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 24884552 | 183703 | 1 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 512 | 5 | 2 | 7 | 4.0 | C[C@@H](NC(=O)C1(O)CCC(F)(F)CC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL484055 | 183703 | 1 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 512 | 5 | 2 | 7 | 4.0 | C[C@@H](NC(=O)C1(O)CCC(F)(F)CC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 44455004 | 97224 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 506 | 5 | 2 | 7 | 3.9 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1Cl | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL271283 | 97224 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 506 | 5 | 2 | 7 | 3.9 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1Cl | 10.1016/j.bmcl.2007.11.050 | ||
| 16102897 | 86797 | 13 | None | 7 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL232943 | 86797 | 13 | None | 7 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 44587184 | 169576 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 630 | 9 | 3 | 6 | 5.3 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL444431 | 169576 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 630 | 9 | 3 | 6 | 5.3 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 16102897 | 86797 | 13 | None | 7 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL232943 | 86797 | 13 | None | 7 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 16102897 | 86797 | 13 | None | 7 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL232943 | 86797 | 13 | None | 7 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2008.08.014 | ||
| 23628223 | 87493 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 520 | 6 | 2 | 4 | 5.0 | COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL233968 | 87493 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 520 | 6 | 2 | 4 | 5.0 | COC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 57390218 | 69703 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 538 | 8 | 3 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939760 | 69703 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 538 | 8 | 3 | 5 | 3.7 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNCC(C)(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44580743 | 192034 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 462 | 5 | 2 | 7 | 3.4 | C[C@@H](NC(=O)C1(O)CCCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL521735 | 192034 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 462 | 5 | 2 | 7 | 3.4 | C[C@@H](NC(=O)C1(O)CCCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 11757682 | 121513 | 0 | None | -28 | 4 | Dog | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL359553 | 121513 | 0 | None | -28 | 4 | Dog | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 11284564 | 155038 | 1 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 572 | 10 | 2 | 7 | 5.0 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL404484 | 155038 | 1 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 572 | 10 | 2 | 7 | 5.0 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 | 10.1016/j.bmcl.2007.11.057 | ||
| 11363856 | 84100 | 0 | None | 5 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| CHEMBL222038 | 84100 | 0 | None | 5 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| 11225601 | 141483 | 0 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| CHEMBL387638 | 141483 | 0 | None | 6 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| 16726096 | 154717 | 7 | None | 2 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL402831 | 154717 | 7 | None | 2 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2008.07.126 | ||
| 10217706 | 82798 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 494 | 6 | 2 | 5 | 4.4 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 | 10.1021/jm061094b | ||
| CHEMBL218605 | 82798 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 494 | 6 | 2 | 5 | 4.4 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 | 10.1021/jm061094b | ||
| 16102883 | 165302 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 470 | 7 | 2 | 4 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(Cl)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL424919 | 165302 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 470 | 7 | 2 | 4 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(Cl)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 57400696 | 69702 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939759 | 69702 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 2.8 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CNC4CC4)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 10151875 | 136442 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 470 | 6 | 2 | 4 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL374580 | 136442 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 470 | 6 | 2 | 4 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 44455035 | 95267 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 5 | 2 | 7 | 3.4 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL258324 | 95267 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 5 | 2 | 7 | 3.4 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.11.050 | ||
| 10031511 | 16750 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| CHEMBL1253497 | 16750 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| 10031511 | 16750 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1253497 | 16750 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 9894973 | 101275 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1016/j.bmcl.2008.08.014 | ||
| CHEMBL299832 | 101275 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1016/j.bmcl.2008.08.014 | ||
| 57383007 | 126675 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 584 | 8 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 | nan | ||
| CHEMBL3657638 | 126675 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 584 | 8 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 | nan | ||
| 16747694 | 87511 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 6 | 2 | 6 | 5.4 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234097 | 87511 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 6 | 2 | 6 | 5.4 | N#CC1(c2ccccc2C(F)(F)F)CCC(CNc2ncccc2NC(=O)c2ccno2)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 24895550 | 173343 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 481 | 8 | 2 | 7 | 3.8 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| CHEMBL454086 | 173343 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 481 | 8 | 2 | 7 | 3.8 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| 44455090 | 97003 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 506 | 8 | 2 | 6 | 4.7 | CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL270173 | 97003 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 506 | 8 | 2 | 6 | 4.7 | CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| 10239095 | 83487 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F | 10.1021/jm061094b | ||
| CHEMBL220657 | 83487 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1F | 10.1021/jm061094b | ||
| 44455038 | 95268 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL258326 | 95268 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1noc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| 16726096 | 154717 | 7 | None | 2 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402831 | 154717 | 7 | None | 2 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| 16102898 | 165639 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 510 | 6 | 2 | 6 | 3.7 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(Cl)c2-c2nnn(C)n2)cc1F | 10.1021/jm061094b | ||
| CHEMBL426561 | 165639 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 510 | 6 | 2 | 6 | 3.7 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(Cl)c2-c2nnn(C)n2)cc1F | 10.1021/jm061094b | ||
| 44580049 | 183995 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 476 | 5 | 2 | 8 | 2.5 | C[C@@H](NC(=O)C1(O)CCC(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL484881 | 183995 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 476 | 5 | 2 | 8 | 2.5 | C[C@@H](NC(=O)C1(O)CCC(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 44593650 | 183998 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 498 | 5 | 2 | 7 | 3.6 | CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL484882 | 183998 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 498 | 5 | 2 | 7 | 3.6 | CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 44432186 | 86257 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 504 | 6 | 2 | 4 | 4.5 | COC(=O)c1c(F)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL231734 | 86257 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 504 | 6 | 2 | 4 | 4.5 | COC(=O)c1c(F)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 10196170 | 136019 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 520 | 7 | 2 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL373803 | 136019 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 520 | 7 | 2 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11442712 | 84788 | 0 | None | -1 | 3 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL225607 | 84788 | 0 | None | -1 | 3 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 44580048 | 183551 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 512 | 5 | 2 | 9 | 1.6 | C[C@@H](NC(=O)C1(O)CCS(=O)(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL482829 | 183551 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 512 | 5 | 2 | 9 | 1.6 | C[C@@H](NC(=O)C1(O)CCS(=O)(=O)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 16041612 | 172389 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 499 | 8 | 2 | 7 | 4.0 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| CHEMBL451761 | 172389 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 499 | 8 | 2 | 7 | 4.0 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| 24893993 | 173342 | 5 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 4.4 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| CHEMBL454085 | 173342 | 5 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 4.4 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| 44587183 | 172645 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 616 | 8 | 3 | 6 | 5.0 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL452331 | 172645 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 616 | 8 | 3 | 6 | 5.0 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 16108961 | 908 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm070055c | ||
| 664 | 908 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm070055c | ||
| CHEMBL415848 | 908 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm070055c | ||
| 11387915 | 15038 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 611 | 10 | 2 | 4 | 6.4 | C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210744 | 15038 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 611 | 10 | 2 | 4 | 6.4 | C=C(CN1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 24893993 | 173342 | 5 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 4.4 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 | 10.1021/jm1000776 | ||
| CHEMBL454085 | 173342 | 5 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 480 | 8 | 2 | 6 | 4.4 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1)OCC1CCCO1 | 10.1021/jm1000776 | ||
| 11488817 | 77169 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 495 | 9 | 0 | 6 | 2.5 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087433 | 77169 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 495 | 9 | 0 | 6 | 2.5 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 11386138 | 84006 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL221998 | 84006 | 0 | None | 1 | 3 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 11477390 | 84723 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 | 10.1021/jm049394l | ||
| CHEMBL225218 | 84723 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1nc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)no1 | 10.1021/jm049394l | ||
| 44411294 | 76965 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208371 | 76965 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 16726109 | 146349 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 487 | 6 | 2 | 5 | 3.7 | COC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL392551 | 146349 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 487 | 6 | 2 | 5 | 3.7 | COC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 16108961 | 908 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 664 | 908 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| CHEMBL415848 | 908 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2)N[C@@H]1CCOc2c1ccc(c2)CN1CCCCC1 | 10.1021/jm061224g | ||
| 44455073 | 95129 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 506 | 5 | 2 | 6 | 5.0 | Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL257729 | 95129 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 506 | 5 | 2 | 6 | 5.0 | Cc1noc(-c2c(Cl)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)n1 | 10.1016/j.bmcl.2007.11.050 | ||
| 57382836 | 126657 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 501 | 7 | 2 | 7 | 3.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)COC2)c(F)c1 | nan | ||
| CHEMBL3657620 | 126657 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 501 | 7 | 2 | 7 | 3.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3ccno3)COC2)c(F)c1 | nan | ||
| 68869647 | 77159 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 522 | 10 | 0 | 7 | 1.7 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C4CC4)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087423 | 77159 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 522 | 10 | 0 | 7 | 1.7 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C4CC4)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 11167607 | 136808 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL375288 | 136808 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 44580742 | 187295 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 506 | 6 | 3 | 7 | 3.7 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(CO)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL496529 | 187295 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 506 | 6 | 3 | 7 | 3.7 | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(-c2cc(Cl)cc(F)c2-c2noc(CO)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 44418930 | 82889 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 470 | 7 | 2 | 4 | 3.6 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL219083 | 82889 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 470 | 7 | 2 | 4 | 3.6 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 16102896 | 83111 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 486 | 7 | 2 | 4 | 4.1 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL220371 | 83111 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 486 | 7 | 2 | 4 | 4.1 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11281533 | 64731 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182378 | 64731 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 11620871 | 165471 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL425588 | 165471 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411452 | 76550 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 520 | 8 | 1 | 6 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207022 | 76550 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 520 | 8 | 1 | 6 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL2369827 | 207939 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCCN)C(=O)O | 10.1021/jm990961s | ||||
| 44455574 | 155081 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 7 | 2 | 3 | 4.9 | CCOc1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL404683 | 155081 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 472 | 7 | 2 | 3 | 4.9 | CCOc1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| 44455875 | 155085 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 556 | 9 | 2 | 3 | 5.9 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OC(CF)CF)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL404705 | 155085 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 556 | 9 | 2 | 3 | 5.9 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OC(CF)CF)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 10031511 | 16750 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| CHEMBL1253497 | 16750 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm1000776 | ||
| 10031511 | 16750 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1253497 | 16750 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 16102918 | 83843 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(C)=O)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL221288 | 83843 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(C)=O)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 44580209 | 183678 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 478 | 5 | 2 | 8 | 2.6 | C[C@@H](NC(=O)C1(O)CCOCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL483858 | 183678 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 478 | 5 | 2 | 8 | 2.6 | C[C@@H](NC(=O)C1(O)CCOCC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 57382837 | 126658 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 3.6 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(C)no3)COC2)c(F)c1 | nan | ||
| CHEMBL3657621 | 126658 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 3.6 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cc(C)no3)COC2)c(F)c1 | nan | ||
| 57382923 | 126667 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 557 | 7 | 2 | 9 | 3.1 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| CHEMBL3657630 | 126667 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 557 | 7 | 2 | 9 | 3.1 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| 57382925 | 126669 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 555 | 7 | 2 | 9 | 3.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccnnc4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657632 | 126669 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 555 | 7 | 2 | 9 | 3.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccnnc4)COC3)c(F)c2)no1 | nan | ||
| 11281533 | 64731 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182378 | 64731 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 11320189 | 65139 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 746 | 17 | 1 | 8 | 4.5 | CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c(C(=O)N3CCOCC3)c2)CC1 | 10.1021/jm049747g | ||
| CHEMBL183048 | 65139 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 746 | 17 | 1 | 8 | 4.5 | CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c(C(=O)N3CCOCC3)c2)CC1 | 10.1021/jm049747g | ||
| 70685471 | 73488 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 576 | 8 | 2 | 5 | 5.1 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018866 | 73488 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 576 | 8 | 2 | 5 | 5.1 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| 44593650 | 183998 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 498 | 5 | 2 | 7 | 3.6 | CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL484882 | 183998 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 498 | 5 | 2 | 7 | 3.6 | CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 11786597 | 67121 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 583 | 8 | 2 | 6 | 4.4 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2ccnc2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL189245 | 67121 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 583 | 8 | 2 | 6 | 4.4 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2ccnc2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 57382750 | 126650 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 555 | 7 | 2 | 9 | 3.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncnc4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657613 | 126650 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 555 | 7 | 2 | 9 | 3.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncnc4)COC3)c(F)c2)no1 | nan | ||
| 57382839 | 126660 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 585 | 8 | 2 | 10 | 3.2 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 | nan | ||
| CHEMBL3657623 | 126660 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 585 | 8 | 2 | 10 | 3.2 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)cn1 | nan | ||
| 57383057 | 126684 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 599 | 10 | 2 | 8 | 4.0 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 | nan | ||
| CHEMBL3657647 | 126684 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 599 | 10 | 2 | 8 | 4.0 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 | nan | ||
| 57383099 | 126688 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 584 | 8 | 2 | 10 | 2.7 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 | nan | ||
| CHEMBL3657651 | 126688 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 584 | 8 | 2 | 10 | 2.7 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 | nan | ||
| 44432215 | 86520 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 528 | 6 | 2 | 6 | 3.9 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL232354 | 86520 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 528 | 6 | 2 | 6 | 3.9 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| 11444668 | 154992 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 586 | 11 | 2 | 7 | 5.4 | CCOc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL404280 | 154992 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 586 | 11 | 2 | 7 | 5.4 | CCOc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)on1 | 10.1016/j.bmcl.2007.11.057 | ||
| 11386138 | 84006 | 0 | None | -1 | 3 | Rabbit | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL221998 | 84006 | 0 | None | -1 | 3 | Rabbit | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 44587185 | 188341 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 630 | 7 | 3 | 6 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL508043 | 188341 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 630 | 7 | 3 | 6 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 11306090 | 84709 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 476 | 6 | 2 | 4 | 6.6 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1 | 10.1021/jm049394l | ||
| CHEMBL225006 | 84709 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 476 | 6 | 2 | 4 | 6.6 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1 | 10.1021/jm049394l | ||
| 57382924 | 126668 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 557 | 7 | 2 | 8 | 4.3 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 | nan | ||
| CHEMBL3657631 | 126668 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 557 | 7 | 2 | 8 | 4.3 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 | nan | ||
| 57383053 | 126680 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 8 | 2 | 11 | 2.0 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 | nan | ||
| CHEMBL3657643 | 126680 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 8 | 2 | 11 | 2.0 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)cn1 | nan | ||
| 44432221 | 86798 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 501 | 7 | 2 | 5 | 4.1 | CCOC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL232945 | 86798 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 501 | 7 | 2 | 5 | 4.1 | CCOC(=O)c1c(Cl)cccc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 16202227 | 73493 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 636 | 8 | 2 | 5 | 6.1 | O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018871 | 73493 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 636 | 8 | 2 | 5 | 6.1 | O=C(CC1c2cc(F)ccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 24895253 | 186130 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 4.7 | O=C(NCCCN1CCCC(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL488662 | 186130 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 538 | 10 | 3 | 5 | 4.7 | O=C(NCCCN1CCCC(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 44455364 | 154491 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)c2ccon2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL401619 | 154491 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 542 | 9 | 2 | 6 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)c2ccon2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 44587181 | 188082 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 4.3 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL503847 | 188082 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 4.3 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 44421279 | 84718 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 442 | 7 | 2 | 6 | 5.2 | COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL225133 | 84718 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 442 | 7 | 2 | 6 | 5.2 | COC(=O)c1ccc(C)cc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 57398978 | 69700 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 496 | 7 | 2 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939757 | 69700 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 496 | 7 | 2 | 5 | 2.6 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN(C)C)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57382967 | 126674 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 554 | 7 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnc4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657637 | 126674 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 554 | 7 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnc4)COC3)c(F)c2)no1 | nan | ||
| 11281533 | 64731 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182378 | 64731 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 24895550 | 173343 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 481 | 8 | 2 | 7 | 3.8 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| CHEMBL454086 | 173343 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 481 | 8 | 2 | 7 | 3.8 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| 44455549 | 155003 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 506 | 7 | 2 | 3 | 5.6 | CCOc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL404328 | 155003 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 506 | 7 | 2 | 3 | 5.6 | CCOc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| 11215913 | 136003 | 0 | None | 26915 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| CHEMBL373654 | 136003 | 0 | None | 26915 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| 11017305 | 59993 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744084 | 59993 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCN(c4ccncc4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 16102920 | 82783 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 500 | 7 | 2 | 4 | 4.7 | CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL218553 | 82783 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 500 | 7 | 2 | 4 | 4.7 | CCOC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11050306 | 59992 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744083 | 59992 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 10128412 | 86956 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 510 | 6 | 2 | 5 | 4.9 | Cc1nc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL233351 | 86956 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 510 | 6 | 2 | 5 | 4.9 | Cc1nc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 | 10.1016/j.bmcl.2007.04.040 | ||
| 57382838 | 126659 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 574 | 8 | 2 | 10 | 3.4 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 | nan | ||
| CHEMBL3657622 | 126659 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 574 | 8 | 2 | 10 | 3.4 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 | nan | ||
| 57382965 | 126672 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 569 | 7 | 3 | 9 | 3.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncc(N)c4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657635 | 126672 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 569 | 7 | 3 | 9 | 3.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cncc(N)c4)COC3)c(F)c2)no1 | nan | ||
| 57383098 | 126687 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 573 | 8 | 2 | 10 | 2.8 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| CHEMBL3657650 | 126687 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 573 | 8 | 2 | 10 | 2.8 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| 44411062 | 76953 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 522 | 9 | 1 | 6 | 5.0 | CCCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208320 | 76953 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 522 | 9 | 1 | 6 | 5.0 | CCCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11307467 | 154672 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 556 | 9 | 2 | 6 | 5.3 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL402630 | 154672 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 556 | 9 | 2 | 6 | 5.3 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 | 10.1016/j.bmcl.2007.11.057 | ||
| 16102899 | 83914 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 480 | 5 | 2 | 2 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F | 10.1021/jm061094b | ||
| CHEMBL221695 | 83914 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 480 | 5 | 2 | 2 | 5.0 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2C(F)(F)F)cc1F | 10.1021/jm061094b | ||
| 44432181 | 87314 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 510 | 6 | 2 | 6 | 3.7 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)ccc2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL233764 | 87314 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 510 | 6 | 2 | 6 | 3.7 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)ccc2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| 16102907 | 161183 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 456 | 6 | 2 | 4 | 3.2 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL413775 | 161183 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 456 | 6 | 2 | 4 | 3.2 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 10233880 | 77086 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 714 | 17 | 3 | 6 | 4.8 | Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN2CCCC2)Cc2ccc(C(=N)N)cc2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087031 | 77086 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 714 | 17 | 3 | 6 | 4.8 | Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN2CCCC2)Cc2ccc(C(=N)N)cc2)c1Cl | 10.1021/jm2016057 | ||
| 44411358 | 75164 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 534 | 7 | 1 | 6 | 5.1 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL204356 | 75164 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 534 | 7 | 1 | 6 | 5.1 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411364 | 77369 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 522 | 8 | 1 | 6 | 5.0 | CCC(C)N1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208991 | 77369 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 522 | 8 | 1 | 6 | 5.0 | CCC(C)N1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411101 | 140333 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 522 | 8 | 1 | 6 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL381974 | 140333 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 522 | 8 | 1 | 6 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 16102907 | 161183 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 456 | 6 | 2 | 4 | 3.2 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL413775 | 161183 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 456 | 6 | 2 | 4 | 3.2 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44455089 | 96962 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 507 | 7 | 2 | 4 | 5.0 | CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL269963 | 96962 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 507 | 7 | 2 | 4 | 5.0 | CCOc1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| 44455366 | 154786 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 543 | 8 | 2 | 4 | 5.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL403202 | 154786 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 543 | 8 | 2 | 4 | 5.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 44561786 | 172084 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 580 | 9 | 1 | 4 | 7.0 | O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL449789 | 172084 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 580 | 9 | 1 | 4 | 7.0 | O=C(CC(CS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 44432212 | 144624 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 544 | 6 | 2 | 6 | 4.4 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL391227 | 144624 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 544 | 6 | 2 | 6 | 4.4 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| 57382794 | 126652 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 512 | 7 | 2 | 7 | 3.1 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)COC2)c(F)c1 | nan | ||
| CHEMBL3657615 | 126652 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 512 | 7 | 2 | 7 | 3.1 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)c3cncnc3)COC2)c(F)c1 | nan | ||
| 57382877 | 126661 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 575 | 7 | 2 | 10 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4snnc4C)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657624 | 126661 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 575 | 7 | 2 | 10 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4snnc4C)COC3)c(F)c2)no1 | nan | ||
| 57382881 | 126665 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 558 | 7 | 2 | 10 | 2.5 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| CHEMBL3657628 | 126665 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 558 | 7 | 2 | 10 | 2.5 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| 16108960 | 168682 | 0 | None | 30902 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL441188 | 168682 | 0 | None | 30902 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 10196170 | 136019 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 520 | 7 | 2 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL373803 | 136019 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 520 | 7 | 2 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11340940 | 77157 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 496 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087421 | 77157 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 496 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 44580047 | 191983 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 496 | 5 | 2 | 8 | 1.9 | C[C@@H](NC(=O)C1(O)CC[S+]([O-])C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| CHEMBL521454 | 191983 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 496 | 5 | 2 | 8 | 1.9 | C[C@@H](NC(=O)C1(O)CC[S+]([O-])C1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2008.07.126 | ||
| 57395448 | 69699 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 468 | 6 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1939756 | 69699 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 468 | 6 | 3 | 5 | 2.0 | Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 57382922 | 126666 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 544 | 6 | 2 | 7 | 3.1 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | nan | ||
| CHEMBL3657629 | 126666 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 544 | 6 | 2 | 7 | 3.1 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | nan | ||
| 44411054 | 76707 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 508 | 8 | 1 | 6 | 4.6 | CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207378 | 76707 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 508 | 8 | 1 | 6 | 4.6 | CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411093 | 139788 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 548 | 8 | 1 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL380679 | 139788 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 548 | 8 | 1 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 23627521 | 73495 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 648 | 9 | 2 | 6 | 6.0 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018873 | 73495 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 648 | 9 | 2 | 6 | 6.0 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 44587182 | 188095 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 602 | 7 | 2 | 6 | 4.6 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL504119 | 188095 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 602 | 7 | 2 | 6 | 4.6 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 11663809 | 173019 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 536 | 8 | 3 | 6 | 3.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453339 | 173019 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 536 | 8 | 3 | 6 | 3.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 44432222 | 86799 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 535 | 7 | 2 | 5 | 4.8 | CCOC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL232946 | 86799 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 535 | 7 | 2 | 5 | 4.8 | CCOC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 11620238 | 72676 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 497 | 7 | 2 | 5 | 4.1 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncc(C(F)(F)F)c3)CC2)cc1 | 10.1021/jm0511280 | ||
| CHEMBL201041 | 72676 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 497 | 7 | 2 | 5 | 4.1 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncc(C(F)(F)F)c3)CC2)cc1 | 10.1021/jm0511280 | ||
| 44455853 | 168139 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 560 | 7 | 2 | 3 | 6.1 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL436854 | 168139 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 560 | 7 | 2 | 3 | 6.1 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 44587188 | 192758 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 562 | 7 | 3 | 6 | 4.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL525092 | 192758 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 562 | 7 | 3 | 6 | 4.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.055 | ||
| 71454501 | 78584 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 5.9 | COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL2113087 | 78584 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 5.9 | COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 44432198 | 146764 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 534 | 7 | 2 | 4 | 5.4 | CCOC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL392903 | 146764 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 534 | 7 | 2 | 4 | 5.4 | CCOC(=O)c1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 16726096 | 154717 | 7 | None | 2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402831 | 154717 | 7 | None | 2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| 11398971 | 94947 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 570 | 10 | 2 | 6 | 5.5 | CCc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL256903 | 94947 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 570 | 10 | 2 | 6 | 5.5 | CCc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)CC2)no1 | 10.1016/j.bmcl.2007.11.057 | ||
| 16102923 | 84186 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 484 | 7 | 2 | 3 | 5.1 | CCC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL222159 | 84186 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 484 | 7 | 2 | 3 | 5.1 | CCC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11050306 | 59992 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744083 | 59992 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 606 | 9 | 2 | 5 | 6.5 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 659 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm049747g | ||
| 9831083 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm049747g | ||
| CHEMBL273869 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm049747g | ||
| 9961595 | 64258 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 687 | 10 | 1 | 7 | 4.4 | CC(C)N1CCN(C(=O)C2CCN(S(=O)(=O)c3ccc(NCC(c4ccccc4)c4ccccc4)c(C(=O)N4CCOCC4)c3)CC2)CC1 | 10.1021/jm049747g | ||
| CHEMBL181695 | 64258 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 687 | 10 | 1 | 7 | 4.4 | CC(C)N1CCN(C(=O)C2CCN(S(=O)(=O)c3ccc(NCC(c4ccccc4)c4ccccc4)c(C(=O)N4CCOCC4)c3)CC2)CC1 | 10.1021/jm049747g | ||
| 11377529 | 66356 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 706 | 19 | 2 | 8 | 3.8 | CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c(C(=O)N2CCOCC2)c1 | 10.1021/jm049747g | ||
| CHEMBL185551 | 66356 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 706 | 19 | 2 | 8 | 3.8 | CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c(C(=O)N2CCOCC2)c1 | 10.1021/jm049747g | ||
| 11479448 | 127011 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 678 | 17 | 1 | 8 | 5.0 | CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c([N+](=O)[O-])c2)CC1 | 10.1021/jm049747g | ||
| CHEMBL366294 | 127011 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 678 | 17 | 1 | 8 | 5.0 | CN(C)CCCN(CCCN(C)C)C(=O)C1CCN(S(=O)(=O)c2ccc(NCC(c3ccccc3)c3ccccc3)c([N+](=O)[O-])c2)CC1 | 10.1021/jm049747g | ||
| 16221229 | 85128 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 605 | 10 | 3 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227977 | 85128 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 605 | 10 | 3 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CNC3CCC3)ccc21 | 10.1021/jm070055c | ||
| 68868975 | 77162 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 498 | 13 | 0 | 7 | 1.4 | CCN(CC)CCN1CCN(C(=O)COCCN(C)S(=O)(=O)c2c(C)cc(OC)cc2C)CC1 | 10.1021/jm2016057 | ||
| CHEMBL2087426 | 77162 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 498 | 13 | 0 | 7 | 1.4 | CCN(CC)CCN1CCN(C(=O)COCCN(C)S(=O)(=O)c2c(C)cc(OC)cc2C)CC1 | 10.1021/jm2016057 | ||
| 11214151 | 77164 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 497 | 11 | 0 | 6 | 2.8 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(C)(C)CN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087428 | 77164 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 497 | 11 | 0 | 6 | 2.8 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(C)(C)CN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 16102919 | 82739 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 452 | 6 | 2 | 4 | 3.7 | COC(=O)c1ccccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL218319 | 82739 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 452 | 6 | 2 | 4 | 3.7 | COC(=O)c1ccccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 10168110 | 77085 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 625 | 15 | 3 | 6 | 3.2 | Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN)CC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087030 | 77085 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 625 | 15 | 3 | 6 | 3.2 | Cc1c(Cl)ccc(S(=O)(=O)N(CCc2ccccc2)CC(=O)NCC(=O)N(CCCCN)CC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| 44561641 | 186132 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL488677 | 186132 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 44411252 | 76522 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207011 | 76522 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 10875606 | 62729 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1788318 | 62729 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 44455182 | 154836 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](C)O)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL403519 | 154836 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](C)O)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 11476944 | 77161 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 470 | 11 | 0 | 7 | 0.7 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087425 | 77161 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 470 | 11 | 0 | 7 | 0.7 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 24895114 | 178392 | 3 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 428 | 6 | 2 | 4 | 4.3 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm800199h | ||
| CHEMBL470693 | 178392 | 3 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 428 | 6 | 2 | 4 | 4.3 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm800199h | ||
| 44455150 | 96957 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 3.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL269949 | 96957 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 3.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44455227 | 94921 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 391 | 7 | 2 | 4 | 3.6 | CCC(O)(CC)C(=O)NCc1ccc(-c2cccc(F)c2C(=O)OC)cc1F | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL256793 | 94921 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 391 | 7 | 2 | 4 | 3.6 | CCC(O)(CC)C(=O)NCc1ccc(-c2cccc(F)c2C(=O)OC)cc1F | 10.1016/j.bmcl.2007.11.050 | ||
| 44570026 | 175734 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 508 | 11 | 2 | 5 | 3.3 | O=C(O)CCNC(=O)CN(CCOc1cccc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL459532 | 175734 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 508 | 11 | 2 | 5 | 3.3 | O=C(O)CCNC(=O)CN(CCOc1cccc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 60142437 | 125372 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 540 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648466 | 125372 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 540 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 44392025 | 64484 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 4.3 | COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL181968 | 64484 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 414 | 7 | 2 | 6 | 4.3 | COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 49863235 | 15046 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 613 | 10 | 3 | 4 | 6.7 | C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210752 | 15046 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 613 | 10 | 3 | 4 | 6.7 | C=C(CNC(C)(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 25181410 | 171638 | 1 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1021/jm1000776 | ||
| CHEMBL447392 | 171638 | 1 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1021/jm1000776 | ||
| 25181410 | 171638 | 1 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL447392 | 171638 | 1 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 44402076 | 71336 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 456 | 7 | 3 | 4 | 4.9 | CNC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL196494 | 71336 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 456 | 7 | 3 | 4 | 4.9 | CNC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 44401932 | 71415 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 4.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL196698 | 71415 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 4.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 44402028 | 69464 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 400 | 7 | 3 | 5 | 4.2 | Cc1ccnc(NCc2ccc(-c3ccccc3C(=O)O)cc2)c1NC(=O)CC#N | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL193684 | 69464 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 400 | 7 | 3 | 5 | 4.2 | Cc1ccnc(NCc2ccc(-c3ccccc3C(=O)O)cc2)c1NC(=O)CC#N | 10.1016/j.bmcl.2005.02.077 | ||
| 16102908 | 141432 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 402 | 6 | 2 | 4 | 2.7 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(C)=O)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL387331 | 141432 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 402 | 6 | 2 | 4 | 2.7 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(C)=O)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 60141042 | 125403 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 537 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 | nan | ||
| CHEMBL3648497 | 125403 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 537 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)COC2)no1 | nan | ||
| 10388673 | 71044 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 443 | 7 | 2 | 5 | 5.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| CHEMBL195883 | 71044 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 443 | 7 | 2 | 5 | 5.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| 57382747 | 126647 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 545 | 6 | 2 | 7 | 3.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657610 | 126647 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 545 | 6 | 2 | 7 | 3.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)COC3)c(F)c2)no1 | nan | ||
| 44569937 | 187680 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 612 | 13 | 1 | 6 | 4.6 | CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1 | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL499999 | 187680 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 612 | 13 | 1 | 6 | 4.6 | CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1 | 10.1016/j.bmcl.2008.11.005 | ||
| 57383097 | 126686 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 535 | 10 | 2 | 6 | 3.5 | COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 | nan | ||
| CHEMBL3657649 | 126686 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 535 | 10 | 2 | 6 | 3.5 | COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 | nan | ||
| 11719314 | 139966 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 448 | 7 | 2 | 4 | 3.7 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCC2)cc1 | 10.1021/jm0511280 | ||
| CHEMBL381009 | 139966 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 448 | 7 | 2 | 4 | 3.7 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCC2)cc1 | 10.1021/jm0511280 | ||
| 16102909 | 82905 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 484 | 7 | 2 | 4 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(C)(Cl)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL219164 | 82905 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 484 | 7 | 2 | 4 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(C)(Cl)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11225601 | 141483 | 0 | None | -239 | 3 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| CHEMBL387638 | 141483 | 0 | None | -239 | 3 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| 44401887 | 69486 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 389 | 7 | 2 | 5 | 4.5 | CCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL193819 | 69486 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 389 | 7 | 2 | 5 | 4.5 | CCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 49863229 | 15040 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210746 | 15040 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 49863230 | 15041 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 597 | 10 | 2 | 4 | 6.0 | C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210747 | 15041 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 597 | 10 | 2 | 4 | 6.0 | C=C(CN1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 12085131 | 77090 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 3.5 | Cc1c(Cl)ccc(S(=O)(=O)N(C)C/C=C/C(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087036 | 77090 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 3.5 | Cc1c(Cl)ccc(S(=O)(=O)N(C)C/C=C/C(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| 11466010 | 83979 | 0 | None | -1 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 | 10.1021/jm049394l | ||
| CHEMBL221984 | 83979 | 0 | None | -1 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 | 10.1021/jm049394l | ||
| 10388673 | 71044 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 443 | 7 | 2 | 5 | 5.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL195883 | 71044 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 443 | 7 | 2 | 5 | 5.0 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 60141327 | 125413 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 6 | 2 | 10 | 3.3 | Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 | nan | ||
| CHEMBL3648507 | 125413 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 6 | 2 | 10 | 3.3 | Cc1nnc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)o1 | nan | ||
| 11685446 | 186112 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL488501 | 186112 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2008.07.108 | ||
| 16221227 | 142474 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 614 | 9 | 3 | 6 | 5.5 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 | 10.1021/jm070055c | ||
| CHEMBL389477 | 142474 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 614 | 9 | 3 | 6 | 5.5 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(C#N)cc1 | 10.1021/jm070055c | ||
| 11224694 | 92320 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 447 | 6 | 3 | 4 | 3.4 | O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL243667 | 92320 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 447 | 6 | 3 | 4 | 3.4 | O=C(Nc1[nH]nc(C(=O)NCCc2ccncc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44570136 | 183012 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 514 | 12 | 1 | 5 | 3.7 | COCCCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL480203 | 183012 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 514 | 12 | 1 | 5 | 3.7 | COCCCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 60142026 | 125358 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 4.1 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| CHEMBL3648453 | 125358 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 4.1 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| 44455229 | 166319 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 363 | 5 | 2 | 4 | 2.8 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(C)(C)O)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL428601 | 166319 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 363 | 5 | 2 | 4 | 2.8 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(C)(C)O)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44392138 | 122082 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 7 | 2 | 6 | 4.0 | COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCC1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL360260 | 122082 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 7 | 2 | 6 | 4.0 | COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCC1 | 10.1016/j.bmcl.2005.05.133 | ||
| 16221225 | 168791 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL442056 | 168791 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| 44401768 | 124988 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 418 | 8 | 2 | 6 | 3.6 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CN(C)C)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL364670 | 124988 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 418 | 8 | 2 | 6 | 3.6 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CN(C)C)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 60142963 | 125395 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648489 | 125395 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 11293092 | 64914 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 421 | 7 | 2 | 7 | 3.4 | COC(=O)c1ccccc1N1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182785 | 64914 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 421 | 7 | 2 | 7 | 3.4 | COC(=O)c1ccccc1N1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| 16726096 | 154717 | 7 | None | -15 | 4 | Rabbit | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402831 | 154717 | 7 | None | -15 | 4 | Rabbit | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| 16221162 | 143779 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 611 | 9 | 2 | 5 | 6.7 | CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL390540 | 143779 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 611 | 9 | 2 | 5 | 6.7 | CC1CCCC(C)N1Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 11039234 | 59994 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744085 | 59994 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| 16102882 | 141022 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 438 | 7 | 2 | 4 | 2.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL384893 | 141022 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 438 | 7 | 2 | 4 | 2.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 44392012 | 64535 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 419 | 7 | 2 | 7 | 3.3 | COC(=O)c1ccccc1N1CC=C(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182177 | 64535 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 419 | 7 | 2 | 7 | 3.3 | COC(=O)c1ccccc1N1CC=C(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| 44392544 | 125705 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 635 | 19 | 2 | 7 | 4.5 | CC(=O)c1cc(S(=O)(=O)NCCC(=O)N(CCCN(C)C)CCCN(C)C)ccc1NCC(c1ccccc1)c1ccccc1 | 10.1021/jm049747g | ||
| CHEMBL365009 | 125705 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 635 | 19 | 2 | 7 | 4.5 | CC(=O)c1cc(S(=O)(=O)NCCC(=O)N(CCCN(C)C)CCCN(C)C)ccc1NCC(c1ccccc1)c1ccccc1 | 10.1021/jm049747g | ||
| 44570139 | 183445 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 474 | 11 | 2 | 5 | 2.7 | O=C(O)CCNC(=O)CN(CCOc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL482173 | 183445 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 474 | 11 | 2 | 5 | 2.7 | O=C(O)CCNC(=O)CN(CCOc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 16108968 | 165574 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL426165 | 165574 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 16221163 | 85131 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL228030 | 85131 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| 44432176 | 86834 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1cc(Cl)ccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL233150 | 86834 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1cc(Cl)ccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 70683374 | 73486 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 640 | 7 | 1 | 5 | 6.8 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018864 | 73486 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 640 | 7 | 1 | 5 | 6.8 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 16220914 | 85129 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 529 | 9 | 3 | 5 | 4.6 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL228014 | 85129 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 529 | 9 | 3 | 5 | 4.6 | CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 11584184 | 172533 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 500 | 8 | 3 | 6 | 2.7 | Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL452057 | 172533 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 500 | 8 | 3 | 6 | 2.7 | Cc1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 44430680 | 141532 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 5.0 | N#CC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL388029 | 141532 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 416 | 6 | 2 | 4 | 5.0 | N#CC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 16221056 | 85120 | 0 | None | 14 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL227870 | 85120 | 0 | None | 14 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 609 | 12 | 3 | 6 | 4.6 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 49863228 | 15036 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 639 | 10 | 2 | 4 | 6.8 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210742 | 15036 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 639 | 10 | 2 | 4 | 6.8 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)N[C@@H]1CCCc2cc(C3(CN4CCCCC4)CC3)ccc21 | 10.1016/j.bmcl.2010.06.010 | ||
| 57382966 | 126673 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 555 | 7 | 2 | 9 | 3.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnn4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657636 | 126673 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 555 | 7 | 2 | 9 | 3.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cccnn4)COC3)c(F)c2)no1 | nan | ||
| 11422305 | 63413 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 638 | 19 | 2 | 8 | 4.2 | CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| CHEMBL180143 | 63413 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 638 | 19 | 2 | 8 | 4.2 | CN(C)CCCN(CCCN(C)C)C(=O)CCNS(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| 70691811 | 73479 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 489 | 5 | 2 | 4 | 4.5 | O=C(CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccccc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018857 | 73479 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 489 | 5 | 2 | 4 | 4.5 | O=C(CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccccc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 10166801 | 102297 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 569 | 8 | 1 | 5 | 6.3 | O=C(CCCN1C(=O)CN=C(C2CCCCC2)c2ccccc21)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 | 10.1021/jm034020y | ||
| CHEMBL30525 | 102297 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 569 | 8 | 1 | 5 | 6.3 | O=C(CCCN1C(=O)CN=C(C2CCCCC2)c2ccccc21)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 | 10.1021/jm034020y | ||
| 44392040 | 172301 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 444 | 7 | 2 | 6 | 4.3 | COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL451549 | 172301 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 444 | 7 | 2 | 6 | 4.3 | COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 57343016 | 77152 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 1.6 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(F)cccc1F | 10.1021/jm2016057 | ||
| CHEMBL2087416 | 77152 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 1.6 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(F)cccc1F | 10.1021/jm2016057 | ||
| 16108963 | 161406 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL415849 | 161406 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 44430679 | 142009 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 421 | 7 | 2 | 4 | 5.1 | COC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL389094 | 142009 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 421 | 7 | 2 | 4 | 5.1 | COC1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 60142025 | 125357 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 536 | 7 | 2 | 3 | 5.6 | O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| CHEMBL3648452 | 125357 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 536 | 7 | 2 | 3 | 5.6 | O=C(NC1(C(=O)NC2CCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| 44569938 | 188302 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 629 | 14 | 1 | 7 | 4.7 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL507546 | 188302 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 629 | 14 | 1 | 7 | 4.7 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 57399671 | 69211 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 506 | 5 | 1 | 4 | 6.6 | Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934265 | 69211 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 506 | 5 | 1 | 4 | 6.6 | Cc1cccc2occ(-c3ccc(C(=O)N[C@H]4CCCc5cc(CN6CCCCC6)ccc54)cc3)c(=O)c12 | 10.1016/j.bmcl.2011.10.068 | ||
| 24895455 | 185832 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 479 | 8 | 3 | 5 | 4.0 | O=C(NCC1CCCO1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL487621 | 185832 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 479 | 8 | 3 | 5 | 4.0 | O=C(NCC1CCCO1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 12085130 | 77088 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 496 | 8 | 1 | 5 | 3.3 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087034 | 77088 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 496 | 8 | 1 | 5 | 3.3 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| 60142835 | 125390 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 550 | 6 | 2 | 7 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648484 | 125390 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 550 | 6 | 2 | 7 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 23627520 | 73492 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 4.7 | COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018870 | 73492 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 4.7 | COc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 16108965 | 160771 | 0 | None | 1000 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| CHEMBL412552 | 160771 | 0 | None | 1000 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| 44561643 | 185056 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 542 | 8 | 3 | 6 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL486456 | 185056 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 542 | 8 | 3 | 6 | 3.7 | CC(C)(C)c1ccc(S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc32)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 60143098 | 125398 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 428 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648492 | 125398 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 428 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(N)CC2)no1 | nan | ||
| 44570137 | 190373 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 2.4 | O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL518616 | 190373 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 2.4 | O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 11604201 | 72969 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 3.2 | COC(=O)c1ccccc1-c1ccc(CNC(=O)[C@@H](C)NC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| CHEMBL201310 | 72969 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 3.2 | COC(=O)c1ccccc1-c1ccc(CNC(=O)[C@@H](C)NC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| 49863234 | 15045 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 611 | 12 | 3 | 4 | 6.3 | C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210751 | 15045 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 611 | 12 | 3 | 4 | 6.3 | C=C(CNCC1CC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 11526891 | 188281 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL507168 | 188281 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.7 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57396212 | 69207 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccc(Cl)cc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934261 | 69207 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccc(Cl)cc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 11676747 | 87449 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 449 | 7 | 2 | 5 | 4.7 | COC(=O)C1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL233873 | 87449 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 449 | 7 | 2 | 5 | 4.7 | COC(=O)C1(c2ccccc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 16102897 | 86797 | 13 | None | -1737 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL232943 | 86797 | 13 | None | -1737 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 70693872 | 73484 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 587 | 8 | 1 | 6 | 4.2 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCN1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018862 | 73484 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 587 | 8 | 1 | 6 | 4.2 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCN1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| 11555599 | 173018 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453338 | 173018 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 56835163 | 69210 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934264 | 69210 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(F)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 44411355 | 76436 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 508 | 6 | 1 | 6 | 3.7 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)=O)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL206935 | 76436 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 508 | 6 | 1 | 6 | 3.7 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)=O)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11039234 | 59994 | 0 | None | -1 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744085 | 59994 | 0 | None | -1 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 592 | 7 | 2 | 5 | 6.2 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(c2ccc(C)cc2)c2ccccc21 | 10.1021/jm034020y | ||
| 16108966 | 83945 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 555 | 10 | 2 | 4 | 6.1 | C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL221925 | 83945 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 555 | 10 | 2 | 4 | 6.1 | C[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)c1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 16108962 | 141176 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL385740 | 141176 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 60142836 | 125391 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 569 | 7 | 2 | 8 | 4.7 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 | nan | ||
| CHEMBL3648485 | 125391 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 569 | 7 | 2 | 8 | 4.7 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)on1 | nan | ||
| 11421944 | 85106 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227778 | 85106 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 88925471 | 125371 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 538 | 5 | 2 | 7 | 3.5 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648465 | 125371 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 538 | 5 | 2 | 7 | 3.5 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 44430681 | 87556 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 5.2 | N#CC1(c2ccccc2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234296 | 87556 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 5.2 | N#CC1(c2ccccc2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 11071992 | 59991 | 0 | None | -3 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744082 | 59991 | 0 | None | -3 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 60142834 | 125389 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 580 | 7 | 2 | 8 | 4.5 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 | nan | ||
| CHEMBL3648483 | 125389 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 580 | 7 | 2 | 8 | 4.5 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cc(F)c43)CC2)cn1 | nan | ||
| 57401425 | 69205 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934259 | 69205 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3ccccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 44411050 | 76835 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 4.3 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCOCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207922 | 76835 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 4.3 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCOCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 24895252 | 185704 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 452 | 9 | 4 | 5 | 3.1 | CNCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL1203967 | 185704 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 452 | 9 | 4 | 5 | 3.1 | CNCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL487444 | 185704 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 452 | 9 | 4 | 5 | 3.1 | CNCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 60143099 | 125399 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 534 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648493 | 125399 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 534 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 11519239 | 185168 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL486640 | 185168 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57383009 | 126677 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 558 | 8 | 2 | 4 | 5.1 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| CHEMBL3657640 | 126677 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 558 | 8 | 2 | 4 | 5.1 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| 16108964 | 141177 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL385741 | 141177 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 583 | 9 | 2 | 5 | 5.9 | O=C(C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCOc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 24970503 | 169199 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 10 | 2 | 7 | 3.4 | COc1cc2c(cc1OC)C(CC(=O)NCCc1ccc(C3=NCCN3)cc1)N(S(=O)(=O)c1ccc(C)cc1)CC2 | 10.1016/j.ejmech.2007.10.030 | ||
| CHEMBL443900 | 169199 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 10 | 2 | 7 | 3.4 | COc1cc2c(cc1OC)C(CC(=O)NCCc1ccc(C3=NCCN3)cc1)N(S(=O)(=O)c1ccc(C)cc1)CC2 | 10.1016/j.ejmech.2007.10.030 | ||
| 44392068 | 64465 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 442 | 7 | 2 | 7 | 4.8 | Cc1noc([C@H]2CC=CC[C@@H]2c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)n1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL181961 | 64465 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 442 | 7 | 2 | 7 | 4.8 | Cc1noc([C@H]2CC=CC[C@@H]2c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)n1 | 10.1016/j.bmcl.2005.05.133 | ||
| 44430686 | 141534 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 6 | 2 | 4 | 5.3 | N#CC1(c2cccc(F)c2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL388031 | 141534 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 6 | 2 | 4 | 5.3 | N#CC1(c2cccc(F)c2F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 16102897 | 86797 | 13 | None | 7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL232943 | 86797 | 13 | None | 7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 11259064 | 136589 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 433 | 6 | 2 | 5 | 5.4 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL374779 | 136589 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 433 | 6 | 2 | 5 | 5.4 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2C#N)cc1 | 10.1021/jm049394l | ||
| 10128103 | 144978 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL391491 | 144978 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 16041612 | 172389 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 499 | 8 | 2 | 7 | 4.0 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| CHEMBL451761 | 172389 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 499 | 8 | 2 | 7 | 4.0 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| 24895454 | 186006 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 522 | 10 | 3 | 6 | 3.6 | O=C(NCCCN1CCOCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL487876 | 186006 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 522 | 10 | 3 | 6 | 3.6 | O=C(NCCCN1CCOCC1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 57342336 | 77089 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 526 | 10 | 1 | 6 | 2.9 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087035 | 77089 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 526 | 10 | 1 | 6 | 2.9 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| 16726096 | 154717 | 7 | None | -2 | 4 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402831 | 154717 | 7 | None | -2 | 4 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| 57383010 | 126678 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 574 | 8 | 2 | 11 | 2.2 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| CHEMBL3657641 | 126678 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 574 | 8 | 2 | 11 | 2.2 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4nnn(C)n4)cc3F)COC2)on1 | nan | ||
| 44392156 | 64596 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 420 | 7 | 2 | 6 | 4.3 | COC(=O)C1CCCCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182275 | 64596 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 420 | 7 | 2 | 6 | 4.3 | COC(=O)C1CCCCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 44411095 | 168242 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 508 | 7 | 1 | 6 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL437704 | 168242 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 508 | 7 | 1 | 6 | 4.6 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 70695989 | 73483 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 570 | 8 | 2 | 5 | 4.4 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018861 | 73483 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 570 | 8 | 2 | 5 | 4.4 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 57383008 | 126676 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 557 | 9 | 2 | 6 | 4.8 | C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| CHEMBL3657639 | 126676 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 557 | 9 | 2 | 6 | 4.8 | C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ccc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| 44455492 | 94622 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 520 | 7 | 2 | 3 | 6.0 | CC(C)Oc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL255325 | 94622 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 520 | 7 | 2 | 3 | 6.0 | CC(C)Oc1c(Cl)cc(Cl)cc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.057 | ||
| 57382748 | 126648 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 544 | 7 | 2 | 9 | 3.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccno4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657611 | 126648 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 544 | 7 | 2 | 9 | 3.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4ccno4)COC3)c(F)c2)no1 | nan | ||
| 44432207 | 86795 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 544 | 6 | 2 | 5 | 5.5 | Cc1nc(-c2c(Cl)cc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL232933 | 86795 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 544 | 6 | 2 | 5 | 5.5 | Cc1nc(-c2c(Cl)cc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)no1 | 10.1016/j.bmcl.2007.04.040 | ||
| 57382749 | 126649 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 3.7 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 | nan | ||
| CHEMBL3657612 | 126649 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 3.7 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(F)c4-c4noc(C)n4)cc3F)COC2)on1 | nan | ||
| 16102884 | 82729 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 472 | 7 | 2 | 4 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL218267 | 82729 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 472 | 7 | 2 | 4 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 57523216 | 125382 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 562 | 7 | 2 | 8 | 4.4 | COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| CHEMBL3648476 | 125382 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 562 | 7 | 2 | 8 | 4.4 | COc1ncc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| 57382746 | 126646 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 639 | 7 | 2 | 7 | 5.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cc(F)cc(C(F)(F)F)c4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657609 | 126646 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 639 | 7 | 2 | 7 | 5.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cc(F)cc(C(F)(F)F)c4)COC3)c(F)c2)no1 | nan | ||
| 57382835 | 126656 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 569 | 9 | 2 | 7 | 4.0 | C[C@@H](NC(=O)C1(NC(=O)c2cncnc2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| CHEMBL3657619 | 126656 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 569 | 9 | 2 | 7 | 4.0 | C[C@@H](NC(=O)C1(NC(=O)c2cncnc2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| 44432220 | 86759 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 521 | 6 | 2 | 5 | 4.4 | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL232750 | 86759 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 521 | 6 | 2 | 5 | 4.4 | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1016/j.bmcl.2007.04.040 | ||
| 24895550 | 173343 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 481 | 8 | 2 | 7 | 3.8 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| CHEMBL454086 | 173343 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 481 | 8 | 2 | 7 | 3.8 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1)OCC1CCCO1 | 10.1021/jm800199h | ||
| 11456015 | 154826 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 10 | 2 | 6 | 5.8 | C[C@@H](NC(=O)C1(NC(=O)c2cc(C3CC3)on2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| CHEMBL403434 | 154826 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 10 | 2 | 6 | 5.8 | C[C@@H](NC(=O)C1(NC(=O)c2cc(C3CC3)on2)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | 10.1016/j.bmcl.2007.11.057 | ||
| 44587041 | 187284 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 574 | 6 | 3 | 6 | 4.0 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL496459 | 187284 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 574 | 6 | 3 | 6 | 4.0 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 71454502 | 78587 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 7 | 2 | 6 | 4.9 | COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL2113091 | 78587 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 7 | 2 | 6 | 4.9 | COC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 11363856 | 84100 | 0 | None | -5 | 3 | Rabbit | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| CHEMBL222038 | 84100 | 0 | None | -5 | 3 | Rabbit | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| 44411442 | 139893 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 7 | 1 | 6 | 5.5 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL380920 | 139893 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 548 | 7 | 1 | 6 | 5.5 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCCCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 16102885 | 82782 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 3.2 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL218552 | 82782 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 454 | 7 | 2 | 4 | 3.2 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)Cl)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 57342845 | 77145 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 10 | 1 | 6 | 2.4 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C(F)(F)F | 10.1021/jm2016057 | ||
| CHEMBL2087409 | 77145 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 10 | 1 | 6 | 2.4 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C(F)(F)F | 10.1021/jm2016057 | ||
| 44411353 | 75199 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 520 | 7 | 1 | 6 | 4.7 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL204562 | 75199 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 520 | 7 | 1 | 6 | 4.7 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C4CCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 70691814 | 73490 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 592 | 8 | 2 | 5 | 5.6 | Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018868 | 73490 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 592 | 8 | 2 | 5 | 5.6 | Cc1cc(C)c(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1C | 10.1016/j.bmcl.2012.03.065 | ||
| 16102881 | 82930 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 7 | 2 | 4 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL219309 | 82930 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 7 | 2 | 4 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(NC(=O)C(F)(F)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 60142027 | 125359 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648454 | 125359 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 16221054 | 141528 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 591 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL387982 | 141528 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 591 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cc(Cl)c(F)cc1F)c1ccccc1 | 10.1021/jm070055c | ||
| 11452874 | 151845 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 418 | 4 | 3 | 3 | 4.3 | O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| CHEMBL397037 | 151845 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 418 | 4 | 3 | 3 | 4.3 | O=C(Nc1[nH]nc(C(=O)Nc2ccccc2)c1Br)c1ccccc1Cl | 10.1021/jm051292n | ||
| 44402075 | 71650 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 417 | 9 | 2 | 5 | 5.3 | CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1021/jm049394l | ||
| CHEMBL197462 | 71650 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 417 | 9 | 2 | 5 | 5.3 | CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1021/jm049394l | ||
| 44402075 | 71650 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 417 | 9 | 2 | 5 | 5.3 | CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL197462 | 71650 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 417 | 9 | 2 | 5 | 5.3 | CCCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 24895354 | 178302 | 3 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 395 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1 | 10.1021/jm800199h | ||
| CHEMBL469875 | 178302 | 3 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 395 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccn2)cc1 | 10.1021/jm800199h | ||
| 16726096 | 154717 | 7 | None | -239 | 4 | Dog | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402831 | 154717 | 7 | None | -239 | 4 | Dog | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 490 | 5 | 2 | 6 | 4.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c2)no1 | 10.1016/j.bmcl.2007.11.050 | ||
| 49863232 | 15043 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 601 | 12 | 4 | 5 | 4.9 | C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210749 | 15043 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 601 | 12 | 4 | 5 | 4.9 | C=C(CNCCO)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 44569935 | 168914 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 646 | 13 | 1 | 6 | 5.3 | CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL443207 | 168914 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 646 | 13 | 1 | 6 | 5.3 | CC(C)COc1ccc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 16221160 | 96808 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 597 | 10 | 3 | 5 | 6.3 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL268911 | 96808 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 597 | 10 | 3 | 5 | 6.3 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CNC3CCCCC3)ccc21 | 10.1021/jm070055c | ||
| 44569939 | 178143 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 580 | 12 | 1 | 7 | 4.2 | COc1ccccc1CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL468492 | 178143 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 580 | 12 | 1 | 7 | 4.2 | COc1ccccc1CCNC(=O)CN(CCOc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 60141184 | 125407 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 427 | 4 | 2 | 7 | 2.3 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 | nan | ||
| CHEMBL3648501 | 125407 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 427 | 4 | 2 | 7 | 2.3 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)n1 | nan | ||
| 44410972 | 76910 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 467 | 6 | 1 | 6 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCOCC3)ccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208086 | 76910 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 467 | 6 | 1 | 6 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCOCC3)ccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 60142305 | 125370 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 538 | 5 | 2 | 6 | 4.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648464 | 125370 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 538 | 5 | 2 | 6 | 4.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 44411349 | 139821 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 550 | 6 | 1 | 6 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)C(C)(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL380834 | 139821 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 550 | 6 | 1 | 6 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)C(C)(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 24895450 | 190787 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 423 | 6 | 2 | 4 | 3.8 | CN(C)C(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL519247 | 190787 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 423 | 6 | 2 | 4 | 3.8 | CN(C)C(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 24895186 | 185585 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 409 | 6 | 3 | 4 | 3.5 | CNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL487263 | 185585 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 409 | 6 | 3 | 4 | 3.5 | CNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 60142024 | 125356 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 446 | 5 | 2 | 4 | 3.5 | COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| CHEMBL3648451 | 125356 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 446 | 5 | 2 | 4 | 3.5 | COC(=O)c1ccccc1-c1ccc2c(c1)CCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| 10311064 | 77615 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 484 | 7 | 2 | 4 | 4.2 | COC(=O)c1c(F)cccc1-c1ccc([C@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL2096845 | 77615 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 484 | 7 | 2 | 4 | 4.2 | COC(=O)c1c(F)cccc1-c1ccc([C@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 44570138 | 183013 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 456 | 8 | 1 | 4 | 3.3 | CNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL480204 | 183013 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 456 | 8 | 1 | 4 | 3.3 | CNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 44411360 | 76514 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 3.1 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL206982 | 76514 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 3.1 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 24895351 | 189256 | 3 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 412 | 6 | 2 | 4 | 3.8 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL516783 | 189256 | 3 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 412 | 6 | 2 | 4 | 3.8 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2)cc1 | 10.1021/jm800199h | ||
| 11284458 | 140045 | 2 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL381366 | 140045 | 2 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 565 | 7 | 2 | 4 | 5.7 | CC(C)(C)NCc1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 11670860 | 185170 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL486641 | 185170 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)CCS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 60141039 | 125401 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 553 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| CHEMBL3648495 | 125401 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 553 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| 11376509 | 63970 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 567 | 16 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| CHEMBL181098 | 63970 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 567 | 16 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| 44401703 | 132944 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.7 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL370704 | 132944 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.7 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)C(C)C)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 70695304 | 77082 | 0 | None | -17 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 556 | 8 | 2 | 6 | 4.0 | Cc1ccc2cccc(OCc3cc(S(=O)(=O)N4CCC[C@H]4C(=O)NCC4CCNCC4)ccc3Cl)c2n1 | 10.1021/jm2016057 | ||
| CHEMBL2087027 | 77082 | 0 | None | -17 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 556 | 8 | 2 | 6 | 4.0 | Cc1ccc2cccc(OCc3cc(S(=O)(=O)N4CCC[C@H]4C(=O)NCC4CCNCC4)ccc3Cl)c2n1 | 10.1021/jm2016057 | ||
| 70688994 | 77083 | 0 | None | 18 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 433 | 5 | 2 | 4 | 2.6 | Cc1c(Cl)ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NCC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087028 | 77083 | 0 | None | 18 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 433 | 5 | 2 | 4 | 2.6 | Cc1c(Cl)ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NCC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| 60142168 | 125364 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 550 | 7 | 2 | 3 | 6.0 | O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| CHEMBL3648459 | 125364 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 550 | 7 | 2 | 3 | 6.0 | O=C(NC1(C(=O)NC2CCCc3cc(-c4cc(Cl)cc(Cl)c4OCC(F)F)ccc32)CC1)C(F)(F)F | nan | ||
| CHEMBL2369828 | 207940 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1c2ccccc2C[C@H]1C(=O)O | 10.1021/jm990961s | ||||
| 60142439 | 125376 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 5 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648470 | 125376 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 5 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 24895256 | 185830 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 453 | 9 | 3 | 5 | 3.5 | COCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL487620 | 185830 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 453 | 9 | 3 | 5 | 3.5 | COCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 24895184 | 192971 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 413 | 6 | 2 | 5 | 3.2 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1 | 10.1021/jm800199h | ||
| CHEMBL530549 | 192971 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 413 | 6 | 2 | 5 | 3.2 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cn2)cc1 | 10.1021/jm800199h | ||
| 9919335 | 106090 | 1 | None | 489 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 922 | 22 | 9 | 13 | -2.1 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC2(CC1)C(=O)N(CC(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(=O)O)C1=O)CN2CCc1ccccc1 | 10.1021/jm990962k | ||
| CHEMBL3142392 | 106090 | 1 | None | 489 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 922 | 22 | 9 | 13 | -2.1 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC2(CC1)C(=O)N(CC(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(=O)O)C1=O)CN2CCc1ccccc1 | 10.1021/jm990962k | ||
| 44430684 | 87602 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.1 | N#CC1(c2cccc(C(F)(F)F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234512 | 87602 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.1 | N#CC1(c2cccc(C(F)(F)F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 44455108 | 154593 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL402114 | 154593 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 16221164 | 161185 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 577 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL413786 | 161185 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 577 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(C)(C)C)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| 57382878 | 126662 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 521 | 8 | 2 | 8 | 2.7 | COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)COC1 | nan | ||
| CHEMBL3657625 | 126662 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 521 | 8 | 2 | 8 | 2.7 | COCC(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(F)c3-c3noc(C)n3)cc2F)COC1 | nan | ||
| 44392045 | 131248 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.3 | COC(=O)c1ccccc1C1=CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL369307 | 131248 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.3 | COC(=O)c1ccccc1C1=CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| 44411347 | 76520 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 3.8 | C#CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207000 | 76520 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 3.8 | C#CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 16221053 | 141805 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 9 | 3 | 5 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL388720 | 141805 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 9 | 3 | 5 | 5.4 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(F)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 11575578 | 73574 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 430 | 7 | 2 | 6 | 2.5 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 | 10.1021/jm0511280 | ||
| CHEMBL202090 | 73574 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 430 | 7 | 2 | 6 | 2.5 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)c3cncnc3)CC2)cc1 | 10.1021/jm0511280 | ||
| 60141181 | 125404 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 551 | 6 | 2 | 8 | 4.1 | Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| CHEMBL3648498 | 125404 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 551 | 6 | 2 | 8 | 4.1 | Cc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| 44391977 | 122245 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 2 | 7 | 3.4 | COC(=O)c1cccn1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL360500 | 122245 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 403 | 7 | 2 | 7 | 3.4 | COC(=O)c1cccn1-c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 11180748 | 167768 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 17 | 1 | 7 | 4.8 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(Cc2ccccc2)Cc2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| CHEMBL434341 | 167768 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 17 | 1 | 7 | 4.8 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(Cc2ccccc2)Cc2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| 24895111 | 176136 | 3 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 412 | 6 | 2 | 4 | 3.8 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2F)cc1 | 10.1021/jm800199h | ||
| CHEMBL460045 | 176136 | 3 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 412 | 6 | 2 | 4 | 3.8 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2F)cc1 | 10.1021/jm800199h | ||
| 44411080 | 165662 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 556 | 8 | 1 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL426681 | 165662 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 556 | 8 | 1 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 60141326 | 125412 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 444 | 4 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 | nan | ||
| CHEMBL3648506 | 125412 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 444 | 4 | 2 | 7 | 3.1 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(N)CC2)n1 | nan | ||
| 16220987 | 78687 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL2113274 | 78687 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 44411071 | 76513 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 530 | 8 | 1 | 6 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)F)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL206975 | 76513 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 530 | 8 | 1 | 6 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)F)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 24895182 | 178276 | 3 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.0 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2F)cc1 | 10.1021/jm800199h | ||
| CHEMBL469675 | 178276 | 3 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.0 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2F)cc1 | 10.1021/jm800199h | ||
| 10187347 | 192747 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 544 | 7 | 2 | 5 | 5.5 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL52498 | 192747 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 544 | 7 | 2 | 5 | 5.5 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(N(C)C)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 44411252 | 76522 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207011 | 76522 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 57390932 | 69200 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934254 | 69200 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3cccc(Cl)c3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 60142962 | 125394 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 552 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 | nan | ||
| CHEMBL3648488 | 125394 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 552 | 7 | 2 | 9 | 4.0 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)on1 | nan | ||
| 88574592 | 126663 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 588 | 10 | 2 | 8 | 4.2 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 | nan | ||
| CHEMBL3657626 | 126663 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 588 | 10 | 2 | 8 | 4.2 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 | nan | ||
| 11225601 | 141483 | 0 | None | -6 | 3 | Rabbit | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| CHEMBL387638 | 141483 | 0 | None | -6 | 3 | Rabbit | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnn(C)n2)cc1 | 10.1021/jm049394l | ||
| 60142570 | 125381 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 | nan | ||
| CHEMBL3648475 | 125381 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)CC2)no1 | nan | ||
| 23627396 | 73489 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 618 | 8 | 2 | 5 | 6.0 | O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018867 | 73489 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 618 | 8 | 2 | 5 | 6.0 | O=C(CC1c2ccccc2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 57342494 | 77147 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 512 | 10 | 1 | 6 | 2.6 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087411 | 77147 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 512 | 10 | 1 | 6 | 2.6 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1cccc(Cl)c1Cl | 10.1021/jm2016057 | ||
| 57383011 | 126679 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 598 | 10 | 2 | 7 | 4.6 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 | nan | ||
| CHEMBL3657642 | 126679 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 598 | 10 | 2 | 7 | 4.6 | COc1ncc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)cn1 | nan | ||
| 44411368 | 76784 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 520 | 8 | 1 | 6 | 4.8 | C/C=C/CN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207800 | 76784 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 520 | 8 | 1 | 6 | 4.8 | C/C=C/CN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11331054 | 15037 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 625 | 10 | 2 | 4 | 6.8 | C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210743 | 15037 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 625 | 10 | 2 | 4 | 6.8 | C=C(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 68869570 | 77156 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 522 | 9 | 0 | 7 | 1.7 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CC4CCC(C3)N4C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087420 | 77156 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 522 | 9 | 0 | 7 | 1.7 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(C3CC4CCC(C3)N4C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 44411457 | 76344 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 8 | 1 | 6 | 5.0 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL206519 | 76344 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 534 | 8 | 1 | 6 | 5.0 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC4CCC4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411051 | 76706 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 4.2 | CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207377 | 76706 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 4.2 | CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 49863236 | 15048 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 611 | 11 | 3 | 4 | 6.5 | C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210754 | 15048 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 611 | 11 | 3 | 4 | 6.5 | C=C(CNC1CCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 60141324 | 125411 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 552 | 7 | 2 | 10 | 2.8 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| CHEMBL3648505 | 125411 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 552 | 7 | 2 | 10 | 2.8 | COc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| 57383054 | 126681 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 4.8 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 | nan | ||
| CHEMBL3657644 | 126681 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 4.8 | COc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 | nan | ||
| 44411138 | 165269 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4cccnc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL424868 | 165269 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4cccnc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11433587 | 15039 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210745 | 15039 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 627 | 10 | 3 | 5 | 5.4 | C=C(CN1CC[C@H](O)C1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 68867798 | 77165 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 469 | 11 | 0 | 6 | 2.1 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CCN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087429 | 77165 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 469 | 11 | 0 | 6 | 2.1 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CCN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 60142703 | 125383 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648477 | 125383 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 532 | 6 | 2 | 7 | 4.4 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 60141182 | 125405 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 567 | 7 | 2 | 9 | 3.8 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| CHEMBL3648499 | 125405 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 567 | 7 | 2 | 9 | 3.8 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)COC2)on1 | nan | ||
| 44430694 | 87479 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.9 | N#CC1(c2ccccc2OC(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL233887 | 87479 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.9 | N#CC1(c2ccccc2OC(F)(F)F)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 44430692 | 87478 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 450 | 6 | 2 | 4 | 5.7 | N#CC1(c2ccccc2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL233886 | 87478 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 450 | 6 | 2 | 4 | 5.7 | N#CC1(c2ccccc2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 44430682 | 141533 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 5.2 | N#CC1(c2cccc(F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL388030 | 141533 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 5.2 | N#CC1(c2cccc(F)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 16220918 | 160911 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 585 | 9 | 2 | 6 | 4.7 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL412762 | 160911 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 585 | 9 | 2 | 6 | 4.7 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCOCC3)ccc21 | 10.1021/jm070055c | ||
| 11227059 | 67011 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 584 | 8 | 2 | 7 | 3.8 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2cnnc2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL188617 | 67011 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 584 | 8 | 2 | 7 | 3.8 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(-n2cnnc2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 44432223 | 166585 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 545 | 6 | 2 | 7 | 3.8 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL429074 | 166585 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 545 | 6 | 2 | 7 | 3.8 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ncc(-c2cc(Cl)cc(Cl)c2-c2nnn(C)n2)cc1F | 10.1016/j.bmcl.2007.04.040 | ||
| 70687620 | 73487 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 624 | 7 | 1 | 5 | 5.5 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N1CCC(Cc2ccc(C3=NCCN3)cc2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018865 | 73487 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 624 | 7 | 1 | 5 | 5.5 | O=C(CC1c2ccccc2CCN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N1CCC(Cc2ccc(C3=NCCN3)cc2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| 11341448 | 77168 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 524 | 10 | 0 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C(C)C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087432 | 77168 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 524 | 10 | 0 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C(C)C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 60142706 | 125386 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 551 | 7 | 2 | 8 | 4.6 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| CHEMBL3648480 | 125386 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 551 | 7 | 2 | 8 | 4.6 | COc1cc(C(=O)NC2(C(=O)N[C@H]3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)on1 | nan | ||
| 44430687 | 87604 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.3 | N#CC1(c2ccc(Cl)c(Cl)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234514 | 87604 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.3 | N#CC1(c2ccc(Cl)c(Cl)c2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 49863237 | 15049 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 625 | 11 | 3 | 4 | 6.9 | C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210755 | 15049 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 625 | 11 | 3 | 4 | 6.9 | C=C(CNC1CCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 11454567 | 77166 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 485 | 11 | 1 | 7 | 1.1 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(O)CN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087430 | 77166 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 485 | 11 | 1 | 7 | 1.1 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(C(O)CN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 60142167 | 125363 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 538 | 5 | 2 | 7 | 2.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 | nan | ||
| CHEMBL3648458 | 125363 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 538 | 5 | 2 | 7 | 2.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)n1 | nan | ||
| 11284303 | 65995 | 0 | None | -2 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 553 | 15 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| CHEMBL185068 | 65995 | 0 | None | -2 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 553 | 15 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| 16220913 | 85112 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 515 | 8 | 3 | 5 | 4.3 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227828 | 85112 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 515 | 8 | 3 | 5 | 4.3 | NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 11467345 | 161390 | 0 | None | 489 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL415629 | 161390 | 0 | None | 489 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 57403175 | 69204 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934258 | 69204 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3c(Cl)cccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 44401834 | 123487 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 442 | 7 | 3 | 4 | 4.6 | CNC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL362974 | 123487 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 442 | 7 | 3 | 4 | 4.6 | CNC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 60142566 | 125375 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 5 | 2 | 6 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648469 | 125375 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 5 | 2 | 6 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)OCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 24895353 | 178365 | 3 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.0 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)c(F)c2)cc1 | 10.1021/jm800199h | ||
| CHEMBL470487 | 178365 | 3 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.0 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)c(F)c2)cc1 | 10.1021/jm800199h | ||
| 11757682 | 121513 | 0 | None | -1949 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| CHEMBL359553 | 121513 | 0 | None | -1949 | 4 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 567 | 8 | 3 | 6 | 3.5 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2004.09.074 | ||
| 44411392 | 140712 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 6 | 1 | 7 | 4.0 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)OC)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL383089 | 140712 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 6 | 1 | 7 | 4.0 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C(=O)OC)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 49863227 | 15035 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 627 | 10 | 2 | 4 | 6.9 | CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210741 | 15035 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 627 | 10 | 2 | 4 | 6.9 | CC(CN1CCCCC1)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 68869351 | 77155 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 508 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@H]3CN4CCC3CC4)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087419 | 77155 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 508 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@H]3CN4CCC3CC4)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 44569936 | 172604 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 627 | 14 | 1 | 6 | 5.9 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL452238 | 172604 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 627 | 14 | 1 | 6 | 5.9 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCCCC3)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 11495796 | 73173 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 436 | 7 | 2 | 4 | 3.6 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| CHEMBL201717 | 73173 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 436 | 7 | 2 | 4 | 3.6 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C(C)(C)NC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| 44391980 | 64670 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.4 | COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCCC1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182331 | 64670 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.4 | COC(=O)C1=C(c2ccc(CNc3nccc(C)c3NC(=O)CC#N)cc2)CCCC1 | 10.1016/j.bmcl.2005.05.133 | ||
| 11442712 | 84788 | 0 | None | -89 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL225607 | 84788 | 0 | None | -89 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 11386138 | 84006 | 0 | None | -50 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| CHEMBL221998 | 84006 | 0 | None | -50 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 482 | 7 | 2 | 6 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)Nc2nccc(Cl)c2NC(=O)CC#N)cc1 | 10.1021/jm049394l | ||
| 44392010 | 65513 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 435 | 7 | 2 | 7 | 3.7 | COC(=O)c1ccccc1N1CCC(C)(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL183538 | 65513 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 435 | 7 | 2 | 7 | 3.7 | COC(=O)c1ccccc1N1CCC(C)(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| 60142569 | 125380 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 426 | 4 | 2 | 5 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648474 | 125380 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 426 | 4 | 2 | 5 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(N)CC2)no1 | nan | ||
| 60142837 | 125392 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 527 | 5 | 2 | 7 | 5.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| CHEMBL3648486 | 125392 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 527 | 5 | 2 | 7 | 5.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| 16220988 | 85096 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227697 | 85096 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 | 10.1021/jm070055c | ||
| 25181410 | 171638 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1021/jm1000776 | ||
| CHEMBL447392 | 171638 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 642 | 14 | 1 | 7 | 4.6 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1OCC(C)C | 10.1021/jm1000776 | ||
| 60142166 | 125362 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 538 | 5 | 2 | 6 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 | nan | ||
| CHEMBL3648457 | 125362 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 538 | 5 | 2 | 6 | 4.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)COC2)no1 | nan | ||
| 44392040 | 172301 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 444 | 7 | 2 | 6 | 4.3 | COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL451549 | 172301 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 444 | 7 | 2 | 6 | 4.3 | COC(=O)C1C2C=CC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 60142165 | 125361 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 496 | 5 | 2 | 5 | 3.3 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 | nan | ||
| CHEMBL3648456 | 125361 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 496 | 5 | 2 | 5 | 3.3 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CC[C@@H]2NC(=O)C1(NC(=O)C(F)(F)F)COC1 | nan | ||
| 123884 | 2264 | 13 | None | -87 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 641 | 2264 | 13 | None | -87 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| CHEMBL80472 | 2264 | 13 | None | -87 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 16108967 | 83912 | 0 | None | 147 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL221691 | 83912 | 0 | None | 147 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 44391962 | 64389 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 420 | 7 | 2 | 6 | 4.4 | COC(=O)c1ccccc1C1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL181899 | 64389 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 420 | 7 | 2 | 6 | 4.4 | COC(=O)c1ccccc1C1CCC(CNc2nccc(C)c2NC(=O)CC#N)CC1 | 10.1016/j.bmcl.2005.05.133 | ||
| 10001334 | 69767 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 8 | 2 | 6 | 3.7 | COCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL194018 | 69767 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 8 | 2 | 6 | 3.7 | COCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 16220986 | 137079 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL375709 | 137079 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 555 | 9 | 3 | 5 | 5.3 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/jm070055c | ||
| 57403174 | 69202 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934256 | 69202 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 510 | 5 | 1 | 4 | 6.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(F)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 60142963 | 125395 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648489 | 125395 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 60143095 | 125396 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 563 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 | nan | ||
| CHEMBL3648490 | 125396 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 563 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)cnc43)CC2)cn1 | nan | ||
| 56835162 | 69206 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934260 | 69206 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cccc(Cl)c3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 44411343 | 76896 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 520 | 9 | 1 | 6 | 4.8 | C=CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208006 | 76896 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 520 | 9 | 1 | 6 | 4.8 | C=CCCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 60142704 | 125384 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 521 | 6 | 2 | 7 | 4.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| CHEMBL3648478 | 125384 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 521 | 6 | 2 | 7 | 4.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| 11635365 | 173979 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL455642 | 173979 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57342496 | 77148 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 512 | 10 | 1 | 6 | 2.6 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(Cl)cccc1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087412 | 77148 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 512 | 10 | 1 | 6 | 2.6 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1c(Cl)cccc1Cl | 10.1021/jm2016057 | ||
| 57382921 | 123887 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 545 | 6 | 2 | 8 | 2.5 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | nan | ||
| CHEMBL3639564 | 123887 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 545 | 6 | 2 | 8 | 2.5 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)COC1)c1ncc(-c2cc(Cl)cc(F)c2-c2nnn(C)n2)cc1F | nan | ||
| 57383055 | 126682 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 4.5 | Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 | nan | ||
| CHEMBL3657645 | 126682 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 4.5 | Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ccc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 | nan | ||
| 70693873 | 73485 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 576 | 8 | 2 | 5 | 5.4 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018863 | 73485 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 576 | 8 | 2 | 5 | 5.4 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CCC2=NCCN2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| 57342849 | 77149 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 2.0 | COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(Cl)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087413 | 77149 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 2.0 | COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(Cl)c1 | 10.1021/jm2016057 | ||
| 60142303 | 125368 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648462 | 125368 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60141466 | 125416 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 569 | 7 | 2 | 10 | 3.6 | COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 | nan | ||
| CHEMBL3648510 | 125416 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 569 | 7 | 2 | 10 | 3.6 | COc1cc(C(=O)NC2(C(=O)NC3CSc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)ccc43)CC2)on1 | nan | ||
| 16047262 | 76840 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 1 | 6 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207937 | 76840 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 1 | 6 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 60141185 | 125408 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 563 | 7 | 2 | 10 | 2.6 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 | nan | ||
| CHEMBL3648502 | 125408 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 563 | 7 | 2 | 10 | 2.6 | COc1ncc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)cn1 | nan | ||
| 11260745 | 77160 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 510 | 10 | 0 | 7 | 1.4 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CC3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087424 | 77160 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 510 | 10 | 0 | 7 | 1.4 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CC3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 46911684 | 15047 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 599 | 11 | 3 | 4 | 6.3 | C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210753 | 15047 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 599 | 11 | 3 | 4 | 6.3 | C=C(CNC(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 57382797 | 126655 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 558 | 9 | 2 | 7 | 4.2 | C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| CHEMBL3657618 | 126655 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 558 | 9 | 2 | 7 | 4.2 | C[C@@H](NC(=O)C1(NC(=O)c2ccno2)COC1)c1ncc(-c2cc(Cl)cc(Cl)c2OCC(F)F)cc1F | nan | ||
| 23627458 | 73491 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 564 | 8 | 2 | 5 | 5.0 | Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018869 | 73491 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 564 | 8 | 2 | 5 | 5.0 | Cc1ccc(S(=O)(=O)N2c3ccccc3-c3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 16221228 | 165453 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 593 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL425490 | 165453 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 593 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 68870388 | 77171 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 510 | 10 | 0 | 7 | 1.4 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CN3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087435 | 77171 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 510 | 10 | 0 | 7 | 1.4 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(CN3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 60141041 | 125402 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 548 | 6 | 2 | 8 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 | nan | ||
| CHEMBL3648496 | 125402 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 548 | 6 | 2 | 8 | 3.6 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3cncnc3)COC2)no1 | nan | ||
| 60141464 | 125414 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 550 | 6 | 2 | 9 | 3.4 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 | nan | ||
| CHEMBL3648508 | 125414 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 550 | 6 | 2 | 9 | 3.4 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3cncnc3)CC2)n1 | nan | ||
| 16221055 | 142204 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 607 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL389249 | 142204 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 607 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 44430688 | 87717 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.3 | N#CC1(c2cccc(Cl)c2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234720 | 87717 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 484 | 6 | 2 | 4 | 6.3 | N#CC1(c2cccc(Cl)c2Cl)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 10456579 | 124084 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 453 | 8 | 2 | 7 | 3.1 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL364073 | 124084 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 453 | 8 | 2 | 7 | 3.1 | COC(=O)c1ccccc1-c1ccc(CNc2ncccc2NC(=O)CS(C)(=O)=O)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 16221226 | 143853 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 569 | 9 | 3 | 5 | 5.6 | Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL390603 | 143853 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 569 | 9 | 3 | 5 | 5.6 | Cc1c(Cl)cccc1S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCOc2cc(CNC(C)(C)C)ccc21)c1ccccc1 | 10.1021/jm070055c | ||
| 11663606 | 192972 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL530554 | 192972 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 520 | 8 | 2 | 5 | 4.5 | O=C(C[C@H](O)CS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 11466010 | 83979 | 0 | None | -6 | 3 | Rabbit | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 | 10.1021/jm049394l | ||
| CHEMBL221984 | 83979 | 0 | None | -6 | 3 | Rabbit | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 | 10.1021/jm049394l | ||
| 60142302 | 125367 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 536 | 5 | 2 | 5 | 5.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648461 | 125367 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 536 | 5 | 2 | 5 | 5.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 44569940 | 178144 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 514 | 11 | 2 | 5 | 3.1 | O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL468493 | 178144 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 514 | 11 | 2 | 5 | 3.1 | O=C(O)CCNC(=O)CN(CCOc1ccc2c(c1)CCC2)S(=O)(=O)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2008.11.005 | ||
| 57401426 | 69208 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934262 | 69208 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3cc(Cl)ccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 49863233 | 15044 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 615 | 13 | 3 | 5 | 5.6 | C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210750 | 15044 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 615 | 13 | 3 | 5 | 5.6 | C=C(CNCCOC)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 57399670 | 69199 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934253 | 69199 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2ccc(C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc43)cc2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| 24895449 | 186125 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 413 | 6 | 2 | 5 | 3.2 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)nc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL488626 | 186125 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 413 | 6 | 2 | 5 | 3.2 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)nc2)cc1 | 10.1021/jm800199h | ||
| 11620980 | 173130 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453596 | 173130 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2008.07.108 | ||
| 24895355 | 186107 | 3 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccncc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL488461 | 186107 | 3 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccncc2)cc1 | 10.1021/jm800199h | ||
| 4227718 | 178458 | 7 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL471371 | 178458 | 7 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 4227718 | 178458 | 7 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm1000776 | ||
| CHEMBL471371 | 178458 | 7 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm1000776 | ||
| 60142833 | 125388 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 444 | 4 | 2 | 5 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648482 | 125388 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 444 | 4 | 2 | 5 | 4.2 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| 11641218 | 72870 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 462 | 7 | 2 | 4 | 4.1 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCC2)cc1 | 10.1021/jm0511280 | ||
| CHEMBL201210 | 72870 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 462 | 7 | 2 | 4 | 4.1 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCC2)cc1 | 10.1021/jm0511280 | ||
| 60142707 | 125387 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 544 | 5 | 2 | 6 | 5.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| CHEMBL3648481 | 125387 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 544 | 5 | 2 | 6 | 5.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cc(F)c3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| 11596635 | 86374 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 4.5 | O=C(CC(F)(F)F)Nc1cccnc1NCC1CCC(O)(c2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL232237 | 86374 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 407 | 6 | 3 | 4 | 4.5 | O=C(CC(F)(F)F)Nc1cccnc1NCC1CCC(O)(c2ccccc2)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 44455147 | 97592 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 3.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL273156 | 97592 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 3.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 11635364 | 173980 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL455643 | 173980 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 554 | 8 | 3 | 6 | 3.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 70689675 | 73480 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 572 | 8 | 2 | 6 | 4.0 | O=C(CC1COc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018858 | 73480 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 572 | 8 | 2 | 6 | 4.0 | O=C(CC1COc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 57392728 | 69209 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934263 | 69209 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc21)c1ccc(-c2coc3c(Cl)cccc3c2=O)cc1 | 10.1016/j.bmcl.2011.10.068 | ||
| 70685470 | 73482 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 570 | 8 | 2 | 5 | 4.2 | O=C(CC1Cc2ccccc2CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018860 | 73482 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 570 | 8 | 2 | 5 | 4.2 | O=C(CC1Cc2ccccc2CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 44430685 | 87603 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 4.8 | COC(=O)c1cccc(C2(C#N)CCC(CNc3ncccc3NC(=O)CC(F)(F)F)CC2)c1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234513 | 87603 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 4.8 | COC(=O)c1cccc(C2(C#N)CCC(CNc3ncccc3NC(=O)CC(F)(F)F)CC2)c1 | 10.1016/j.bmcl.2007.03.059 | ||
| 16221111 | 85100 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227721 | 85100 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 16221109 | 143503 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 607 | 9 | 3 | 5 | 6.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL390311 | 143503 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 607 | 9 | 3 | 5 | 6.1 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 88574478 | 126654 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 4.5 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 | nan | ||
| CHEMBL3657617 | 126654 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 572 | 9 | 2 | 7 | 4.5 | Cc1cc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)on1 | nan | ||
| 57382880 | 126664 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 559 | 7 | 2 | 10 | 3.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nnc(C)o4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657627 | 126664 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 559 | 7 | 2 | 10 | 3.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nnc(C)o4)COC3)c(F)c2)no1 | nan | ||
| 11620871 | 165471 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL425588 | 165471 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccncc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411068 | 140368 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 512 | 8 | 1 | 6 | 4.2 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCF)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL382228 | 140368 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 512 | 8 | 1 | 6 | 4.2 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCF)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 57382795 | 126653 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 3.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)COC2)c(F)c1 | nan | ||
| CHEMBL3657616 | 126653 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 516 | 7 | 2 | 5 | 3.9 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)CC(F)(F)F)COC2)c(F)c1 | nan | ||
| 60141038 | 125400 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 564 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| CHEMBL3648494 | 125400 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 564 | 7 | 2 | 9 | 3.8 | COc1ncc(C(=O)NC2(C(=O)NC3COc4cc(-c5cc(Cl)cc(F)c5-c5noc(C)n5)ccc43)CC2)cn1 | nan | ||
| 16220916 | 85121 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227879 | 85121 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 571 | 9 | 3 | 5 | 5.8 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 44411393 | 76639 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCNCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207122 | 76639 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 3.5 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCNCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 16221108 | 85092 | 0 | None | 27 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL227600 | 85092 | 0 | None | 27 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 605 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| 57342847 | 77146 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 11 | 1 | 7 | 1.6 | COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087410 | 77146 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 11 | 1 | 7 | 1.6 | COc1ccc(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm2016057 | ||
| 44316621 | 81690 | 0 | None | 57 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1091 | 24 | 13 | 15 | -4.9 | NC(N)=NCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| CHEMBL216618 | 81690 | 0 | None | 57 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1091 | 24 | 13 | 15 | -4.9 | NC(N)=NCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| 24895255 | 184784 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 556 | 10 | 3 | 5 | 5.0 | O=C(NCCCN1CCCC(F)(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL486052 | 184784 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 556 | 10 | 3 | 5 | 5.0 | O=C(NCCCN1CCCC(F)(F)C1)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccccc2)cc1 | 10.1021/jm800199h | ||
| 9852117 | 77154 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 508 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@@H]3CN4CCC3CC4)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087418 | 77154 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 508 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN([C@@H]3CN4CCC3CC4)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 16221161 | 143777 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 569 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| CHEMBL390539 | 143777 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 569 | 9 | 2 | 5 | 5.5 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCC3)ccc21 | 10.1021/jm070055c | ||
| 11071992 | 59991 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL1744082 | 59991 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 584 | 7 | 2 | 5 | 6.4 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc(N3CCC(N4CCCCC4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 71229238 | 125409 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 522 | 6 | 2 | 9 | 2.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| CHEMBL3648503 | 125409 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 522 | 6 | 2 | 9 | 2.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| 68868627 | 77163 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 484 | 12 | 0 | 7 | 1.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCCN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087427 | 77163 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 484 | 12 | 0 | 7 | 1.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCN(CCCN(C)C)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 60142438 | 125373 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 536 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648467 | 125373 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 536 | 5 | 2 | 5 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 16221057 | 142476 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 607 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL389478 | 142476 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 607 | 11 | 3 | 5 | 5.6 | CC(C)CNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 3102216 | 187574 | 6 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 4.2 | COc1ccccc1NC(=O)CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL498679 | 187574 | 6 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 493 | 6 | 2 | 5 | 4.2 | COc1ccccc1NC(=O)CC1C(=O)Nc2ccccc2N1S(=O)(=O)c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2008.07.055 | ||
| 57382963 | 126670 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 557 | 7 | 2 | 9 | 3.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nccn4C)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657633 | 126670 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 557 | 7 | 2 | 9 | 3.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4nccn4C)COC3)c(F)c2)no1 | nan | ||
| 44455255 | 94978 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 335 | 5 | 2 | 4 | 2.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CO)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL257053 | 94978 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 335 | 5 | 2 | 4 | 2.0 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)CO)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44411153 | 140686 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 548 | 7 | 1 | 6 | 4.7 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL382909 | 140686 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 548 | 7 | 1 | 6 | 4.7 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CC(F)(F)F)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11553268 | 74031 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 408 | 7 | 2 | 4 | 2.8 | COC(=O)c1ccccc1-c1ccc(CNC(=O)CNC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| CHEMBL202463 | 74031 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 408 | 7 | 2 | 4 | 2.8 | COC(=O)c1ccccc1-c1ccc(CNC(=O)CNC(=O)CC(F)(F)F)cc1 | 10.1021/jm0511280 | ||
| 60142169 | 125366 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 494 | 5 | 2 | 4 | 4.5 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| CHEMBL3648460 | 125366 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 494 | 5 | 2 | 4 | 4.5 | COC(=O)c1c(Cl)cccc1-c1ccc2c(c1)CCCC2NC(=O)C1(NC(=O)C(F)(F)F)CC1 | nan | ||
| 44392133 | 65749 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 4.5 | COC(=O)C1C2CCC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL183876 | 65749 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 446 | 7 | 2 | 6 | 4.5 | COC(=O)C1C2CCC(CC2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 11555433 | 188392 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 520 | 8 | 3 | 6 | 3.0 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL508632 | 188392 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 520 | 8 | 3 | 6 | 3.0 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 10282203 | 187823 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 600 | 9 | 2 | 5 | 6.8 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL50208 | 187823 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 600 | 9 | 2 | 5 | 6.8 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCC(c4ccncc4)CC3)cc2)N=C(CCc2ccccc2)c2ccccc21 | 10.1021/jm034020y | ||
| 24895181 | 178364 | 3 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.0 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2F)cc1 | 10.1021/jm800199h | ||
| CHEMBL470486 | 178364 | 3 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 430 | 6 | 2 | 4 | 4.0 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(F)cc2F)cc1 | 10.1021/jm800199h | ||
| 11605512 | 173021 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 486 | 8 | 3 | 6 | 2.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL453340 | 173021 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 486 | 8 | 3 | 6 | 2.4 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)[C@H](O)[C@H](O)CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2008.07.108 | ||
| 44587207 | 187555 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 573 | 6 | 2 | 6 | 4.4 | O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL498489 | 187555 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 573 | 6 | 2 | 6 | 4.4 | O=Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2008.07.055 | ||
| 44455074 | 154980 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL404246 | 154980 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 417 | 5 | 2 | 4 | 3.3 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@](C)(O)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 70688995 | 77084 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 611 | 14 | 5 | 6 | 2.9 | Cc1c(Cl)ccc(S(=O)(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087029 | 77084 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 611 | 14 | 5 | 6 | 2.9 | Cc1c(Cl)ccc(S(=O)(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| 44455256 | 166510 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 5 | 2 | 4 | 2.6 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(O)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL428954 | 166510 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 5 | 2 | 4 | 2.6 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(O)CC2)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 11691896 | 186113 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL488512 | 186113 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 8 | 1 | 4 | 5.6 | O=C(CCCS(=O)(=O)c1ccc2ccccc2c1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1016/j.bmcl.2008.07.108 | ||
| 60142961 | 125393 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 427 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| CHEMBL3648487 | 125393 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 427 | 4 | 2 | 6 | 3.5 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(N)CC2)no1 | nan | ||
| 11466010 | 83979 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 | 10.1021/jm049394l | ||
| CHEMBL221984 | 83979 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 490 | 7 | 2 | 8 | 4.8 | C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1 | 10.1021/jm049394l | ||
| 44402298 | 71277 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 470 | 7 | 3 | 4 | 5.5 | CNC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL196352 | 71277 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 470 | 7 | 3 | 4 | 5.5 | CNC(=O)c1ccccc1-c1ccc([C@@H](C)Nc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 60142028 | 125360 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648455 | 125360 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 522 | 5 | 2 | 5 | 4.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60143096 | 125397 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 522 | 6 | 2 | 8 | 4.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| CHEMBL3648491 | 125397 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 522 | 6 | 2 | 8 | 4.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccno3)CC2)no1 | nan | ||
| 60141323 | 125410 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 536 | 6 | 2 | 9 | 3.1 | Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| CHEMBL3648504 | 125410 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 536 | 6 | 2 | 9 | 3.1 | Cc1cc(C(=O)NC2(C(=O)NC3CCc4cc(-c5cc(Cl)cc(F)c5-c5nnn(C)n5)cnc43)CC2)on1 | nan | ||
| 70691812 | 73481 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 570 | 8 | 2 | 5 | 4.6 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018859 | 73481 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 570 | 8 | 2 | 5 | 4.6 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 11526655 | 185975 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| CHEMBL487823 | 185975 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 534 | 9 | 1 | 5 | 5.2 | CO[C@@H](CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)CS(=O)(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.07.108 | ||
| 57382793 | 126651 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 3.6 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)COC2)c(F)c1 | nan | ||
| CHEMBL3657614 | 126651 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 502 | 6 | 2 | 5 | 3.6 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)COC2)c(F)c1 | nan | ||
| 11953367 | 16875 | 12 | None | -19 | 2 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm1000776 | ||
| CHEMBL1254771 | 16875 | 12 | None | -19 | 2 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 502 | 11 | 1 | 7 | 2.0 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c(C)c1 | 10.1021/jm1000776 | ||
| 60142567 | 125378 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 5 | 2 | 7 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648472 | 125378 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 5 | 2 | 7 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 60142440 | 125374 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 536 | 5 | 2 | 6 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648468 | 125374 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 536 | 5 | 2 | 6 | 3.8 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CCC3(C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 16221283 | 85093 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 609 | 12 | 3 | 6 | 4.9 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| CHEMBL227655 | 85093 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 609 | 12 | 3 | 6 | 4.9 | COCCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccc(F)cc1 | 10.1021/jm070055c | ||
| 57342852 | 77151 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 10 | 1 | 6 | 2.3 | Cc1c(Cl)cccc1S(=O)(=O)N(C)CCOCC(=O)N(C)Cc1ccc(C2=NCCN2)cc1 | 10.1021/jm2016057 | ||
| CHEMBL2087415 | 77151 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 10 | 1 | 6 | 2.3 | Cc1c(Cl)cccc1S(=O)(=O)N(C)CCOCC(=O)N(C)Cc1ccc(C2=NCCN2)cc1 | 10.1021/jm2016057 | ||
| 44430683 | 87557 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 5.2 | N#CC1(c2ccc(F)cc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| CHEMBL234297 | 87557 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 5.2 | N#CC1(c2ccc(F)cc2)CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1 | 10.1016/j.bmcl.2007.03.059 | ||
| 54585539 | 61856 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| CHEMBL1777973 | 61856 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 470 | 6 | 3 | 5 | 1.5 | Cc1ccc(S(=O)(=O)N2CCNC(=O)[C@H]2CC(=O)N[C@@H]2CCCc3cc(CN)ccc32)cc1 | 10.1016/j.bmcl.2011.11.112 | ||
| 44411338 | 137888 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 467 | 7 | 1 | 5 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc(CNc2cc(CN3CCCCC3)ccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL377440 | 137888 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 467 | 7 | 1 | 5 | 5.9 | COC(=O)c1c(Cl)cccc1-c1ccc(CNc2cc(CN3CCCCC3)ccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411245 | 76927 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 542 | 7 | 1 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208210 | 76927 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 542 | 7 | 1 | 6 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccc4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 16102922 | 83804 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1F | 10.1021/jm061094b | ||
| CHEMBL220978 | 83804 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 494 | 6 | 2 | 6 | 3.2 | C[C@@H](NC(=O)C1(NC(=O)C(F)(F)F)CC1)c1ccc(-c2cccc(F)c2-c2nnnn2C)cc1F | 10.1021/jm061094b | ||
| 70691813 | 73058 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 640 | 7 | 1 | 5 | 7.0 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2016601 | 73058 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 640 | 7 | 1 | 5 | 7.0 | O=C(CC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc(N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 11546560 | 73573 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 7 | 2 | 4 | 3.4 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 | 10.1021/jm0511280 | ||
| CHEMBL202089 | 73573 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 7 | 2 | 4 | 3.4 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CC2)cc1 | 10.1021/jm0511280 | ||
| 60141183 | 125406 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 5 | 2 | 8 | 3.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 | nan | ||
| CHEMBL3648500 | 125406 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 5 | 2 | 8 | 3.9 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)n1 | nan | ||
| 12085225 | 77150 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 469 | 10 | 1 | 7 | 1.2 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C#N | 10.1021/jm2016057 | ||
| CHEMBL2087414 | 77150 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 469 | 10 | 1 | 7 | 1.2 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccccc1C#N | 10.1021/jm2016057 | ||
| 56594373 | 65537 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1835762 | 65537 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 506 | 5 | 1 | 5 | 5.5 | Cc1nn(-c2cccc(C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc43)c2)c(=O)c2ccccc12 | 10.1016/j.bmcl.2011.10.068 | ||
| 56594241 | 65531 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1835756 | 65531 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 492 | 5 | 1 | 4 | 6.3 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccccc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 44411252 | 76522 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207011 | 76522 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 24895112 | 176137 | 3 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 412 | 6 | 2 | 4 | 3.8 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2)cc1 | 10.1021/jm800199h | ||
| CHEMBL460046 | 176137 | 3 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 412 | 6 | 2 | 4 | 3.8 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccc(F)c2)cc1 | 10.1021/jm800199h | ||
| 12085129 | 77087 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 9 | 1 | 5 | 3.7 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CCCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087033 | 77087 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 9 | 1 | 5 | 3.7 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CCCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| 44455181 | 96977 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](C)O)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL270017 | 96977 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 349 | 5 | 2 | 4 | 2.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@H](C)O)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 60142568 | 125379 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 526 | 5 | 2 | 6 | 5.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| CHEMBL3648473 | 125379 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 526 | 5 | 2 | 6 | 5.7 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)OC(C)(C)C)CC2)no1 | nan | ||
| 24970501 | 187539 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 516 | 8 | 2 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCc3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.ejmech.2007.10.030 | ||
| CHEMBL498394 | 187539 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 516 | 8 | 2 | 5 | 3.4 | Cc1ccc(S(=O)(=O)N2CCc3ccccc3C2CC(=O)NCCc2ccc(C3=NCCN3)cc2)cc1 | 10.1016/j.ejmech.2007.10.030 | ||
| 11281533 | 64731 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL182378 | 64731 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 7 | 2 | 6 | 4.1 | COC(=O)C1CC=CCC1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 60141465 | 125415 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 539 | 6 | 2 | 9 | 3.6 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| CHEMBL3648509 | 125415 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 539 | 6 | 2 | 9 | 3.6 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)c3ccno3)CC2)n1 | nan | ||
| 57383096 | 126685 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 589 | 9 | 2 | 8 | 4.4 | Cc1nnsc1C(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 | nan | ||
| CHEMBL3657648 | 126685 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 589 | 9 | 2 | 8 | 4.4 | Cc1nnsc1C(=O)NC1(C(=O)N[C@H](C)c2ncc(-c3cc(Cl)cc(Cl)c3OCC(F)F)cc2F)COC1 | nan | ||
| 71456247 | 78582 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.3 | COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL2113085 | 78582 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.3 | COC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 16102897 | 86797 | 13 | None | -7 | 3 | Rabbit | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| CHEMBL232943 | 86797 | 13 | None | -7 | 3 | Rabbit | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 4.3 | COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(NC(=O)C(F)(F)F)CC2)c(F)c1 | 10.1021/jm061094b | ||
| 60142963 | 125395 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| CHEMBL3648489 | 125395 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 533 | 6 | 2 | 8 | 3.8 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)c3ccnnc3)CC2)no1 | nan | ||
| 44432178 | 86955 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 510 | 6 | 2 | 5 | 4.9 | Cc1noc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 | 10.1016/j.bmcl.2007.04.040 | ||
| CHEMBL233350 | 86955 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 510 | 6 | 2 | 5 | 4.9 | Cc1noc(-c2ccc(Cl)cc2-c2ccc([C@@H](C)NC(=O)C3(NC(=O)C(F)(F)F)CC3)c(F)c2)n1 | 10.1016/j.bmcl.2007.04.040 | ||
| 16220990 | 85107 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227786 | 85107 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.9 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/jm070055c | ||
| 659 | 2842 | 13 | None | 1 | 2 | Rhesus macaque | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| 9831083 | 2842 | 13 | None | 1 | 2 | Rhesus macaque | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| CHEMBL273869 | 2842 | 13 | None | 1 | 2 | Rhesus macaque | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| 44411091 | 76734 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.1 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCCCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207539 | 76734 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.1 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCCCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 24895352 | 178595 | 3 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 428 | 6 | 2 | 4 | 4.3 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL472303 | 178595 | 3 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 428 | 6 | 2 | 4 | 4.3 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm800199h | ||
| 44455148 | 96956 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 4 | 3.1 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)C)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL269948 | 96956 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 377 | 6 | 2 | 4 | 3.1 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)C)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 24895183 | 187701 | 3 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 395 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccnc2)cc1 | 10.1021/jm800199h | ||
| CHEMBL500312 | 187701 | 3 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 395 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2C(=O)c2cccnc2)cc1 | 10.1021/jm800199h | ||
| 44411252 | 76522 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207011 | 76522 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11375297 | 92126 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 490 | 6 | 3 | 5 | 3.7 | COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| CHEMBL243467 | 92126 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 490 | 6 | 3 | 5 | 3.7 | COC(=O)[C@@H](NC(=O)c1n[nH]c(NC(=O)c2ccccc2Cl)c1Br)c1ccccc1 | 10.1021/jm051292n | ||
| 44392113 | 65520 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 432 | 7 | 2 | 6 | 4.2 | COC(=O)C1C2CCC(C2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| CHEMBL183562 | 65520 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 432 | 7 | 2 | 6 | 4.2 | COC(=O)C1C2CCC(C2)C1c1ccc(CNc2nccc(C)c2NC(=O)CC#N)cc1 | 10.1016/j.bmcl.2005.05.133 | ||
| 11670114 | 72727 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.5 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCCC2)cc1 | 10.1021/jm0511280 | ||
| CHEMBL201107 | 72727 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.5 | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(NC(=O)CC(F)(F)F)CCCCC2)cc1 | 10.1021/jm0511280 | ||
| 57390933 | 69201 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| CHEMBL1934255 | 69201 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 6.9 | O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21)c1cccc(-c2coc3ccc(Cl)cc3c2=O)c1 | 10.1016/j.bmcl.2011.10.068 | ||
| 16220989 | 141955 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL389054 | 141955 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 9 | 3 | 5 | 5.6 | CC(C)(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1 | 10.1021/jm070055c | ||
| 49863231 | 15042 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 585 | 10 | 2 | 4 | 5.9 | C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| CHEMBL1210748 | 15042 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 585 | 10 | 2 | 4 | 5.9 | C=C(CN(C)C)c1ccc2c(c1)CCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.06.010 | ||
| 10187167 | 77172 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 539 | 9 | 2 | 6 | 2.0 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CC(=O)NCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087436 | 77172 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 539 | 9 | 2 | 6 | 2.0 | Cc1c(Cl)ccc(S(=O)(=O)N(C)CC(=O)NCC(=O)N(C)Cc2ccc(C3=NCCN3)cc2)c1Cl | 10.1021/jm2016057 | ||
| 44411372 | 76933 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 506 | 8 | 1 | 6 | 4.4 | C=CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208241 | 76933 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 506 | 8 | 1 | 6 | 4.4 | C=CCN1CCN(C(=O)c2ccc(NCc3ccc(-c4cccc(F)c4C(=O)OC)cc3F)nc2)CC1 | 10.1016/j.bmcl.2006.01.112 | ||
| 659 | 2842 | 13 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| 9831083 | 2842 | 13 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| CHEMBL273869 | 2842 | 13 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 10.1021/jm1000776 | ||
| 16220915 | 85095 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 557 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL227690 | 85095 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 557 | 10 | 3 | 5 | 5.4 | CC(C)NCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 57383056 | 126683 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 573 | 9 | 2 | 8 | 3.9 | Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 | nan | ||
| CHEMBL3657646 | 126683 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 573 | 9 | 2 | 8 | 3.9 | Cc1nnc(C(=O)NC2(C(=O)N[C@H](C)c3ncc(-c4cc(Cl)cc(Cl)c4OCC(F)F)cc3F)COC2)o1 | nan | ||
| 23627583 | 73496 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 655 | 9 | 1 | 5 | 7.5 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018874 | 73496 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 655 | 9 | 1 | 5 | 7.5 | COc1cccc2c1-c1ccccc1N(S(=O)(=O)c1ccc(Cl)c(Cl)c1)C2CC(=O)N[C@H]1CC[C@H](CCN2CCCC2)CC1 | 10.1016/j.bmcl.2012.03.065 | ||
| 16221110 | 84597 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 543 | 10 | 3 | 5 | 5.0 | CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL224071 | 84597 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 543 | 10 | 3 | 5 | 5.0 | CCNCc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 44411092 | 76668 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 467 | 6 | 1 | 6 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCOCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207178 | 76668 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 467 | 6 | 1 | 6 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCOCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11363856 | 84100 | 0 | None | -162 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| CHEMBL222038 | 84100 | 0 | None | -162 | 3 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 490 | 7 | 2 | 7 | 5.9 | Cc1noc(-c2c(F)cccc2-c2ccc([C@@H](C)Nc3nccc(Cl)c3NC(=O)CC#N)cc2)n1 | 10.1021/jm049394l | ||
| 44411297 | 76993 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 354 | 5 | 1 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208538 | 76993 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 354 | 5 | 1 | 4 | 4.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 57382964 | 126671 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 557 | 7 | 2 | 9 | 3.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cn(C)cn4)COC3)c(F)c2)no1 | nan | ||
| CHEMBL3657634 | 126671 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 557 | 7 | 2 | 9 | 3.1 | Cc1nc(-c2c(F)cc(Cl)cc2-c2cnc([C@@H](C)NC(=O)C3(NC(=O)c4cn(C)cn4)COC3)c(F)c2)no1 | nan | ||
| 44316620 | 2081 | 0 | None | -19 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 656 | 2081 | 0 | None | -19 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| CHEMBL408846 | 2081 | 0 | None | -19 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 44455107 | 97532 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 391 | 6 | 2 | 4 | 3.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(C)C)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL272791 | 97532 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 391 | 6 | 2 | 4 | 3.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@](C)(O)C(C)C)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 16220917 | 165771 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 543 | 9 | 2 | 5 | 5.0 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| CHEMBL427279 | 165771 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 543 | 9 | 2 | 5 | 5.0 | CN(C)Cc1ccc2c(c1)OCC[C@H]2NC(=O)C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1 | 10.1021/jm070055c | ||
| 44411252 | 76522 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207011 | 76522 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 543 | 7 | 1 | 7 | 4.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(c4ccccn4)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 12085227 | 77153 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 528 | 11 | 1 | 7 | 2.2 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm2016057 | ||
| CHEMBL2087417 | 77153 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 528 | 11 | 1 | 7 | 2.2 | CN(Cc1ccc(C2=NCCN2)cc1)C(=O)COCCN(C)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm2016057 | ||
| 10281725 | 963 | 0 | None | -7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 10.1021/jm034020y | ||
| 666 | 963 | 0 | None | -7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 10.1021/jm034020y | ||
| CHEMBL299164 | 963 | 0 | None | -7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 10.1021/jm034020y | ||
| 44587206 | 187554 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 6 | 3 | 6 | 4.0 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| CHEMBL498488 | 187554 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 6 | 3 | 6 | 4.0 | O=C(C[C@@H]1C(=O)Nc2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)N[C@@H]1CCOc2cc(CO)ccc21 | 10.1016/j.bmcl.2008.07.055 | ||
| 44402279 | 70819 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.9 | CCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| CHEMBL195617 | 70819 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.9 | CCCC(=O)Nc1cccnc1NCc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1016/j.bmcl.2005.02.077 | ||
| 44455145 | 97450 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 391 | 5 | 2 | 4 | 3.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)(C)C)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL272491 | 97450 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 391 | 5 | 2 | 4 | 3.4 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)[C@@H](O)C(C)(C)C)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 44411134 | 76934 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 480 | 6 | 1 | 6 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCN(C)CC3)ccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208247 | 76934 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 480 | 6 | 1 | 6 | 3.8 | COC(=O)c1c(F)cccc1-c1ccc(CNc2cc(C(=O)N3CCN(C)CC3)ccn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 44411135 | 76935 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 451 | 7 | 1 | 5 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCCCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL208248 | 76935 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 451 | 7 | 1 | 5 | 5.4 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(CN3CCCCC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 23627523 | 73494 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 654 | 8 | 2 | 5 | 6.3 | O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| CHEMBL2018872 | 73494 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 654 | 8 | 2 | 5 | 6.3 | O=C(CC1c2cc(F)cc(F)c2-c2ccccc2N1S(=O)(=O)c1ccc(Cl)c(Cl)c1)NCCc1ccc(C2=NCCN2)cc1 | 10.1016/j.bmcl.2012.03.065 | ||
| 60142304 | 125369 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 523 | 5 | 2 | 7 | 3.0 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| CHEMBL3648463 | 125369 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 523 | 5 | 2 | 7 | 3.0 | Cn1nnc(-c2c(F)cc(Cl)cc2-c2cnc3c(c2)CCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)n1 | nan | ||
| 60142441 | 125377 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 540 | 5 | 2 | 6 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| CHEMBL3648471 | 125377 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 540 | 5 | 2 | 6 | 5.0 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)SCC3NC(=O)C2(NC(=O)C(F)(F)F)CC2)no1 | nan | ||
| 60142705 | 125385 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 536 | 6 | 2 | 8 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 | nan | ||
| CHEMBL3648479 | 125385 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 536 | 6 | 2 | 8 | 4.3 | Cc1nc(-c2c(F)cc(Cl)cc2-c2ccc3c(c2)CC[C@@H]3NC(=O)C2(NC(=O)c3nnc(C)o3)CC2)no1 | nan | ||
| 44411058 | 76829 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 536 | 9 | 1 | 6 | 5.2 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCC(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| CHEMBL207913 | 76829 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 536 | 9 | 1 | 6 | 5.2 | COC(=O)c1c(F)cccc1-c1ccc(CNc2ccc(C(=O)N3CCN(CCC(C)C)CC3)cn2)c(F)c1 | 10.1016/j.bmcl.2006.01.112 | ||
| 11752335 | 77167 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 496 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| CHEMBL2087431 | 77167 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 496 | 9 | 0 | 7 | 1.2 | COc1cc(C)c(S(=O)(=O)N(C)CCOCC(=O)N2CCC(N3CCN(C)CC3)CC2)c(C)c1 | 10.1021/jm2016057 | ||
| 25181411 | 188694 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 587 | 14 | 1 | 6 | 5.0 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| CHEMBL512111 | 188694 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 587 | 14 | 1 | 6 | 5.0 | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN(C)C)cc2)ccc1OCC(C)C | 10.1016/j.bmcl.2008.11.005 | ||
| 44455228 | 94966 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 471 | 5 | 2 | 4 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(O)(C(F)(F)F)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| CHEMBL257016 | 94966 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 471 | 5 | 2 | 4 | 3.9 | COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C(O)(C(F)(F)F)C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2007.11.050 | ||
| 10120979 | 101130 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccccn4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| CHEMBL298860 | 101130 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(N3CCN(c4ccccn4)CC3)cc2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm034020y | ||
| 122227 | 1346 | 27 | None | 6 | 3 | Human | 9.4 | pKd | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | None | ||||
| 3825 | 1346 | 27 | None | 6 | 3 | Human | 9.4 | pKd | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | None | ||||
| 644 | 1346 | 27 | None | 6 | 3 | Human | 9.4 | pKd | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | None | ||||
| CHEMBL264100 | 1346 | 27 | None | 6 | 3 | Human | 9.4 | pKd | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | None | ||||
| 119376 | 1803 | 41 | 3H-BRADYKININ | -54954 | 27 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 247 | 1803 | 41 | 3H-BRADYKININ | -54954 | 27 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| CHEMBL33884 | 1803 | 41 | 3H-BRADYKININ | -54954 | 27 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 393 | 7 | 1 | 6 | 1.6 | O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C | None | ||
| 44208932 | 140163 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| CHEMBL381689 | 140163 | 6 | UNDEFINED | -120226 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| None | 214348 | 0 | 3H-BRADYKININ | -1 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 164 | 3 | 1 | 3 | 0.8 | C1CNC1COC2=CN=CC=C2 | None | ||
| 122173054 | 216002 | 0 | None | 1 | 6 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 1304 | 30 | 18 | 17 | -4.4 | N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 | None | ||
| 122173054 | 216002 | 0 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 1304 | 30 | 18 | 17 | -4.4 | N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 | None | ||
| 3812 | 708 | 37 | None | -309029 | 6 | Human | 4.0 | pKi | = | 4 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 439201 | 708 | 37 | None | -309029 | 6 | Human | 4.0 | pKi | = | 4 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 649 | 708 | 37 | None | -309029 | 6 | Human | 4.0 | pKi | = | 4 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| CHEMBL406291 | 708 | 37 | None | -309029 | 6 | Human | 4.0 | pKi | = | 4 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| DB12126 | 708 | 37 | None | -309029 | 6 | Human | 4.0 | pKi | = | 4 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 123643 | 3763 | 0 | None | -1 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 639 | 3763 | 0 | None | -1 | 2 | Rat | 5.1 | pKi | = | 5.1 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 3812 | 708 | 37 | None | -19498 | 6 | Rat | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 439201 | 708 | 37 | None | -19498 | 6 | Rat | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 649 | 708 | 37 | None | -19498 | 6 | Rat | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| CHEMBL406291 | 708 | 37 | None | -19498 | 6 | Rat | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| DB12126 | 708 | 37 | None | -19498 | 6 | Rat | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 123643 | 3763 | 0 | None | 1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 639 | 3763 | 0 | None | 1 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 164234 | 3409 | 0 | None | -35 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 164234 | 3409 | 0 | None | -35 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | None | None | None | None | 8996175 | ||||
| 643 | 3409 | 0 | None | -35 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 643 | 3409 | 0 | None | -35 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | None | None | None | None | 8996175 | ||||
| 5311111 | 2135 | 0 | None | -44 | 3 | Mouse | 6.3 | pKi | = | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 5311111 | 2135 | 0 | None | -44 | 3 | Mouse | 6.3 | pKi | = | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 650 | 2135 | 0 | None | -44 | 3 | Mouse | 6.3 | pKi | = | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 650 | 2135 | 0 | None | -44 | 3 | Mouse | 6.3 | pKi | = | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 5311111 | 2135 | 0 | None | -25 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 650 | 2135 | 0 | None | -25 | 3 | Rat | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 3812 | 708 | 37 | None | -616 | 6 | Mouse | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 439201 | 708 | 37 | None | -616 | 6 | Mouse | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 649 | 708 | 37 | None | -616 | 6 | Mouse | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| CHEMBL406291 | 708 | 37 | None | -616 | 6 | Mouse | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| DB12126 | 708 | 37 | None | -616 | 6 | Mouse | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 662 | 3611 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 14747609 | ||
| 9853583 | 3611 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 14747609 | ||
| CHEMBL2021721 | 3611 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 14747609 | ||
| 642 | 2266 | 17 | None | 12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 642 | 2266 | 17 | None | 12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| CHEMBL384721 | 2266 | 17 | None | 12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| CHEMBL384721 | 2266 | 17 | None | 12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 661 | 3215 | 0 | None | 63 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 654 | 560 | 0 | None | 10 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 654 | 560 | 0 | None | 10 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8995263 | ||||
| 654 | 560 | 0 | None | 10 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 655 | 561 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | None | None | None | None | 16368899 | ||||
| 655 | 561 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 122227 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 122227 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| 122227 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 122227 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 3825 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 3825 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| 3825 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 3825 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 644 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 644 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| 644 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 644 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| CHEMBL264100 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| CHEMBL264100 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| CHEMBL264100 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| CHEMBL264100 | 1346 | 27 | None | 6 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 658 | 2816 | 0 | None | 3981 | 2 | Human | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 8995263 | ||||
| 665 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | None | 10.5 | Binding | Guide to Pharmacology | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 12812482 | ||
| 9916412 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | None | 10.5 | Binding | Guide to Pharmacology | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 12812482 | ||
| CHEMBL189123 | 957 | 2 | None | 1023 | 2 | Human | 10.5 | pKi | None | 10.5 | Binding | Guide to Pharmacology | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 12812482 | ||
| 5128451 | 1348 | 0 | None | -2818 | 2 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 5128451 | 1348 | 0 | None | -2818 | 2 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 646 | 1348 | 0 | None | -2818 | 2 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 646 | 1348 | 0 | None | -2818 | 2 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 100978427 | 1347 | 0 | None | -35 | 2 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 645 | 1347 | 0 | None | -35 | 2 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 155817380 | 1361 | 0 | None | - | 1 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 648 | 1361 | 0 | None | - | 1 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 102061602 | 1360 | 0 | None | - | 1 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 647 | 1360 | 0 | None | - | 1 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 651 | 260 | 0 | None | - | 1 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 667 | 1934 | 32 | None | -5128 | 6 | Rat | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 71364 | 1934 | 32 | None | -5128 | 6 | Rat | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| CHEMBL2028850 | 1934 | 32 | None | -5128 | 6 | Rat | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| DB06196 | 1934 | 32 | None | -5128 | 6 | Rat | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 123884 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 123884 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 8063797 | ||||
| 123884 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 123884 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 123884 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 641 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 641 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 8063797 | ||||
| 641 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 641 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 641 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| CHEMBL80472 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| CHEMBL80472 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 8063797 | ||||
| CHEMBL80472 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| CHEMBL80472 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| CHEMBL80472 | 2264 | 13 | None | -87 | 3 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 653 | 559 | 0 | None | -316 | 4 | Mouse | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 667 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 667 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 71364 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 71364 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| CHEMBL2028850 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| CHEMBL2028850 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| DB06196 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| DB06196 | 1934 | 32 | None | -1819 | 6 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 101607591 | 2389 | 0 | None | - | 1 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 637 | 2389 | 0 | None | - | 1 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 3081308 | 2815 | 0 | None | -15 | 2 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | None | None | None | None | 8995263 | ||||
| 657 | 2815 | 0 | None | -15 | 2 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | None | None | None | None | 8995263 | ||||
| 44316620 | 2081 | 0 | None | -19 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 10882364 | ||||
| 656 | 2081 | 0 | None | -19 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 10882364 | ||||
| CHEMBL408846 | 2081 | 0 | None | -19 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 10882364 | ||||
| 665 | 957 | 2 | None | -1023 | 2 | Rat | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 12812482 | ||
| 9916412 | 957 | 2 | None | -1023 | 2 | Rat | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 12812482 | ||
| CHEMBL189123 | 957 | 2 | None | -1023 | 2 | Rat | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 585 | 8 | 3 | 6 | 3.6 | O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)C1=NCCN1 | 12812482 | ||
| 164234 | 3409 | 0 | None | 35 | 2 | Rat | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 643 | 3409 | 0 | None | 35 | 2 | Rat | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 100978427 | 1347 | 0 | None | 35 | 2 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 645 | 1347 | 0 | None | 35 | 2 | Rat | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 661 | 3215 | 0 | None | -63 | 2 | Mouse | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 663 | 1345 | 0 | None | -1 | 3 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 663 | 1345 | 0 | None | -1 | 3 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 663 | 1345 | 0 | None | -1 | 3 | Rat | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 640 | 3557 | 0 | None | - | 1 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 123884 | 2264 | 13 | None | -7 | 3 | Rat | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 641 | 2264 | 13 | None | -7 | 3 | Rat | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| CHEMBL80472 | 2264 | 13 | None | -7 | 3 | Rat | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 663 | 1345 | 0 | None | 1 | 3 | Mouse | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 653 | 559 | 0 | None | -15 | 4 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 8856115 | ||||
| 653 | 559 | 0 | None | -15 | 4 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 5311111 | 2135 | 0 | None | 25 | 3 | Human | 8.0 | pKi | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 5311111 | 2135 | 0 | None | 25 | 3 | Human | 8.0 | pKi | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 5311111 | 2135 | 0 | None | 25 | 3 | Human | 8.0 | pKi | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 650 | 2135 | 0 | None | 25 | 3 | Human | 8.0 | pKi | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 650 | 2135 | 0 | None | 25 | 3 | Human | 8.0 | pKi | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||
| 650 | 2135 | 0 | None | 25 | 3 | Human | 8.0 | pKi | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9313952 | ||||
| 659 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 15341478 | ||
| 659 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 15685199 | ||
| 9831083 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 15341478 | ||
| 9831083 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 15685199 | ||
| CHEMBL273869 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 15341478 | ||
| CHEMBL273869 | 2842 | 13 | None | -1 | 2 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 659 | 9 | 1 | 7 | 3.6 | CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N1CCOCC1)NCC(c1ccccc1)c1ccccc1 | 15685199 | ||
| 642 | 2266 | 17 | None | -12 | 2 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| CHEMBL384721 | 2266 | 17 | None | -12 | 2 | Mouse | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 20814785 | 3142 | 0 | None | - | 1 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 577 | 11 | 3 | 7 | 6.6 | Clc1ccc(cc1)CNC(=O)C(Nc1nc(NCc2cccc(c2)Cl)nc(c1)n1ccnc1)CC1CCCCC1 | 10596850 | ||
| 660 | 3142 | 0 | None | - | 1 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 577 | 11 | 3 | 7 | 6.6 | Clc1ccc(cc1)CNC(=O)C(Nc1nc(NCc2cccc(c2)Cl)nc(c1)n1ccnc1)CC1CCCCC1 | 10596850 | ||
| 654 | 560 | 0 | None | -17 | 3 | Mouse | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 123884 | 2264 | 13 | None | 7 | 3 | Mouse | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 641 | 2264 | 13 | None | 7 | 3 | Mouse | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| CHEMBL80472 | 2264 | 13 | None | 7 | 3 | Mouse | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 654 | 560 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 122227 | 1346 | 27 | None | -6 | 3 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 3825 | 1346 | 27 | None | -6 | 3 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 644 | 1346 | 27 | None | -6 | 3 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| CHEMBL264100 | 1346 | 27 | None | -6 | 3 | Rat | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 10422787 | ||||
| 122227 | 1346 | 27 | None | -6 | 3 | Mouse | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 3825 | 1346 | 27 | None | -6 | 3 | Mouse | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 644 | 1346 | 27 | None | -6 | 3 | Mouse | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| CHEMBL264100 | 1346 | 27 | None | -6 | 3 | Mouse | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 10281725 | 963 | 0 | None | 7 | 2 | Rat | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 12723943 | ||
| 666 | 963 | 0 | None | 7 | 2 | Rat | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 12723943 | ||
| CHEMBL299164 | 963 | 0 | None | 7 | 2 | Rat | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 12723943 | ||
| 10281725 | 963 | 0 | None | -7 | 2 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 12723943 | ||
| 666 | 963 | 0 | None | -7 | 2 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 12723943 | ||
| CHEMBL299164 | 963 | 0 | None | -7 | 2 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 579 | 7 | 2 | 6 | 5.7 | CCCN1C(=O)C(NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2cccnc2)N=C(c2c1cccc2)C1CCCCC1 | 12723943 | ||
| 5128451 | 1348 | 0 | None | 2818 | 2 | Mouse | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 646 | 1348 | 0 | None | 2818 | 2 | Mouse | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 8856107 | ||||
| 652 | 556 | 0 | None | - | 1 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 16368899 | ||||
| 636 | 3556 | 0 | None | - | 1 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9111052 | ||||