GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	118037818	134173	0	None	1	2	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	428	4	2	4	4.9	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2	nan
	CHEMBL3718470	134173	0	None	1	2	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	428	4	2	4	4.9	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccc2c(c1)OCO2	nan
	90010773	133375	0	None	1	2	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	375	4	2	4	4.2	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1	nan
	CHEMBL3715750	133375	0	None	1	2	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	375	4	2	4	4.2	O=C(Nc1ccccc1C(=O)Nc1cccc(C(F)(F)F)c1)c1ccno1	nan
	127024071	133489	0	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	2	4.9	O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1	nan
	CHEMBL3716158	133489	0	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assayAgonist activity at RXFP2 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	2	4.9	O=C(Nc1ccc2cc[nH]c2c1)c1ccccc1NC(=O)C1CCCCC1	nan
	12503	1104	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Determined in a HTRF cAMP assay using HEK-RXFP2 cells.Determined in a HTRF cAMP assay using HEK-RXFP2 cells.	Guide to Pharmacology	787	5	1	5	6.6	FC(F)(F)OC1=CC(I)=C(OCC(=O)N2CCN3[C@@H](C2)C(=O)NC4=C(C=C(C=C4)C5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F)C3=O)C=C1	36333465
	11914	2006	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Receptor activationReceptor activation	Guide to Pharmacology		None	None	None		None	22654853
	8346	200	0	None	-165	2	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21878627
	1989	3241	0	None	-17	3	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11913	2681	0	None	-	1	Human	8.7	pKd	=	8.7	Binding	Receptor binding affinityReceptor binding affinity	Guide to Pharmacology		None	None	None		None	24056075
	1995	2005	0	None	16982	2	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	3875	1563	0	None	-	1	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18529069
	11914	2006	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor bindingReceptor binding	Guide to Pharmacology		None	None	None		None	22654853
	3885	2007	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16547350
	8346	200	0	None	-9	2	Human	6.0	pKi	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21878627
	8333	1248	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17120268
	8332	279	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20570702
	1989	3241	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1989	3241	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	155817469	2008	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20560146
	4372	2008	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20560146
	8331	231	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20570702
	155817501	189	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	8330	189	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	134813893	212	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	8329	212	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	1995	2005	0	None	16982	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1995	2005	0	None	16982	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18434306
	1990	3244	0	None	-81	4	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16411781
	1994	3239	0	None	-39	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1992	3238	0	None	-15	2	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15649866
	1988	3242	0	None	-	1	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16411781

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Ligand source activities (1 row/activity)