Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL1627325 207058 0 None -1 8 Human 10.3 pEC50 = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm900604g
2098 3625 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
36511 3625 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3805 3625 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3835 3625 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL235363 3625 31 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL384518 210571 9 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
2098 3625 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
36511 3625 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3805 3625 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3835 3625 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
CHEMBL235363 3625 31 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
2098 3625 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
36511 3625 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3805 3625 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3835 3625 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3625 31 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
2098 3625 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3625 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3625 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3625 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3625 31 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
73356363 89060 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 89060 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355648 96663 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 96663 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
44355117 21573 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 21573 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297675 100140 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 100140 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10259515 156583 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 156583 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL263185 208806 4 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
2089 2715 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3795 2715 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311311 2715 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 2715 21 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL415159 211417 4 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44297866 101561 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 101561 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL441061 212121 16 None 2 2 Guinea pig 8.7 pEC50 = 8.7 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
73348740 89062 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 89062 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355678 23271 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 23271 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10350201 116646 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 116646 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10327810 116223 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 116223 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10055612 95965 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 95965 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
14860666 104927 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL311917 104927 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
2098 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
15931130 101498 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 101498 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
5311135 21508 10 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 21508 10 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
44355179 24129 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 24129 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 206977 0 None -1 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
2098 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
36511 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3805 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3835 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 3625 31 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
10395375 116144 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 116144 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
10462850 24044 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 24044 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
15931129 193298 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 193298 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL81919 214099 0 None -676 2 Guinea pig 6.2 pEC50 = 6.2 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL335054 209724 0 None -20 3 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
44297852 98537 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 98537 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2090 2716 20 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311312 2716 20 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 2716 20 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
11765601 95964 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 95964 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355368 25422 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 25422 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10009596 114997 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 114997 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
73356365 89063 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
CHEMBL2372954 89063 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
108167 2803 5 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
2107 2803 5 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
CHEMBL1178725 2803 5 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
135434109 4202 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL100636 4202 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
9967131 205762 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
CHEMBL94461 205762 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
10363809 111625 17 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL329007 111625 17 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44328454 168162 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL437075 168162 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10111225 205734 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL94328 205734 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10477054 4411 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102032 4411 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10458573 4284 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL101148 4284 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
135488049 206464 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL98524 206464 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
2102 1162 17 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
5311057 1162 17 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
CHEMBL441225 1162 17 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
10480465 206663 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL99792 206663 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10272852 107394 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319301 107394 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9821217 107231 17 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319118 107231 17 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL3215877 107231 17 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9871754 5322 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5322 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
2098 3625 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
36511 3625 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3805 3625 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3835 3625 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
CHEMBL235363 3625 31 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
44433394 146113 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL392368 146113 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433394 146113 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL392368 146113 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
9960689 11885 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183286 11885 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288600 11885 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
9871754 5322 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5322 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
9945487 206007 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95852 206007 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10268178 205915 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95315 205915 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
2102 1162 17 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
5311057 1162 17 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL441225 1162 17 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
104943 55084 34 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
CHEMBL16192 55084 34 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
22879211 206392 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL98125 206392 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44433393 167075 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL430170 167075 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433393 167075 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL430170 167075 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
2098 3625 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
36511 3625 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3805 3625 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3835 3625 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
CHEMBL235363 3625 31 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
132846 96985 21 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL1256740 96985 21 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL27006 96985 21 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
9968267 108056 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL320220 108056 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10089212 4424 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102157 4424 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10047566 164678 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
CHEMBL422931 164678 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
10650495 106922 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 106922 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
11801327 9251 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 9251 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
9871754 5322 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 5322 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
135413536 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
230 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
3490 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
6918365 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
CHEMBL1471 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
DB00673 444 80 None 3 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
9832207 11879 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 11879 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 11879 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10817013 9151 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 9151 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44327794 110921 1 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL327357 110921 1 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL2369600 207879 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
44286165 157837 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1794935 157837 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL40900 157837 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5074991 212568 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10039383 85038 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
CHEMBL22680 85038 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
15542673 205820 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL94834 205820 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44327909 111853 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL329450 111853 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304126 207725 0 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
9832306 112214 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330367 112214 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330462 112214 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
10123138 108026 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL317524 108026 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL320002 108026 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10190842 106727 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL316705 106727 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44286051 11886 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183288 11886 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288840 11886 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44285793 99813 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1201933 99813 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289091 99813 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44331794 4120 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL100178 4120 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL2369697 207895 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10769060 5942 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 5942 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
44285794 141257 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38624 141257 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44213067 11891 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183307 11891 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289727 11891 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10626666 108695 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 108695 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
10602943 106921 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 106921 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
10168749 205877 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95127 205877 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10745241 110029 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 110029 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369696 207894 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10234086 111131 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL328511 111131 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
10258866 16410 5 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL124066 16410 5 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
136035319 162735 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL418800 162735 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10027061 14768 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL120844 14768 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL2304029 207721 0 None - 1 Rat 4.6 pIC50 = 4.6 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10122529 109055 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL322194 109055 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44349304 16782 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL125385 16782 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10212645 13163 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL1191766 13163 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL542908 13163 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542881 112082 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330172 112082 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10233656 206105 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL96442 206105 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10283825 96232 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL264007 96232 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
153996 112158 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 112158 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 112158 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10507650 162766 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 162766 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986134 163270 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL4206396 163270 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
9918576 205596 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL93556 205596 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
44286200 141309 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38652 141309 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10147107 205876 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431850 205876 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95125 205876 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304032 207722 0 None - 1 Rat 4.5 pIC50 = 4.5 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10212223 206389 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431458 206389 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL98079 206389 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
9832207 11879 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 11879 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 11879 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5083565 213089 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10121390 112229 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330499 112229 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10123040 160536 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL411691 160536 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL537027 160536 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542879 112313 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330719 112313 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349364 116318 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL337987 116318 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10578261 9078 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 9078 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
10360490 88297 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL23617 88297 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
44286038 11091 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL1178749 11091 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL39595 11091 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL2304118 207724 0 None - 1 Rat 5.4 pIC50 = 5.4 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O 10.1021/jm00157a009
10190413 205588 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL410270 205588 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL93519 205588 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
10417124 117963 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL341365 117963 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
44349370 116756 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL339488 116756 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
15542871 206109 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
CHEMBL96466 206109 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
10530375 5538 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 5538 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
10917690 205861 0 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95051 205861 0 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
44328187 206388 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL98076 206388 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
135556923 106903 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL317979 106903 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
9832306 112214 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330367 112214 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330462 112214 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL2304130 207727 0 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)O 10.1021/jm00157a009
10917690 205861 0 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 205861 0 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
44285795 96040 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL262540 96040 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44349303 116703 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL339444 116703 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL2304129 207726 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10620143 98792 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL281828 98792 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10327313 16683 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL124979 16683 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
15831290 146061 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39232 146061 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
10603544 110062 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 110062 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
10190056 110937 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL327497 110937 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
44285857 11079 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1178703 11079 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38030 11079 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10190638 205798 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94726 205798 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283825 96232 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL264007 96232 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283765 107588 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
CHEMBL319535 107588 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
15542874 111664 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL329055 111664 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10769059 108117 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 108117 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
10123138 108026 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL317524 108026 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320002 108026 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542673 205820 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94834 205820 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333379 205831 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL94906 205831 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10305069 206104 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96441 206104 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL2304115 207723 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10190056 110937 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL327497 110937 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
10212725 97704 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL273915 97704 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
15542679 108027 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320003 108027 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9918576 205596 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL93556 205596 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
10190413 205588 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL410270 205588 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL93519 205588 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
44328188 111025 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL327888 111025 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542879 112313 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330719 112313 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10121390 112229 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330499 112229 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10123040 160536 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL411691 160536 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL537027 160536 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10190770 206265 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330430 206265 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97357 206265 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10212223 206389 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431458 206389 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL98079 206389 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147107 205876 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431850 205876 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95125 205876 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333241 206048 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL96141 206048 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10233656 206105 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96442 206105 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147218 106967 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL318369 106967 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542881 112082 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330172 112082 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328321 167214 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL430471 167214 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10122529 109055 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL322194 109055 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10169609 205901 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95243 205901 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
10234086 111131 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL328511 111131 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
15542880 205763 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94480 205763 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10168749 205877 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95127 205877 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10305888 205811 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94788 205811 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328320 205857 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL95029 205857 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10284042 206237 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97240 206237 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542869 205865 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95076 205865 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9892984 143721 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39049 143721 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
11801586 5377 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 5377 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986135 162837 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL419500 162837 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL5078626 212790 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1OC[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44331786 107318 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL319212 107318 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
44331715 4651 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL103657 4651 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
44331792 106686 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL316486 106686 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
44349375 114547 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL334304 114547 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10063954 98266 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL277918 98266 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10190770 206265 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330430 206265 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL97357 206265 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349369 16704 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
CHEMBL125093 16704 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
44407908 140014 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 140014 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44408039 75136 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 75136 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408088 139282 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 139282 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408089 139643 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 139643 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408045 75239 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 75239 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
104943 55084 34 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55084 34 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
3086681 2231 14 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2231 14 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2231 14 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44370529 48779 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 48779 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
44408040 74055 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 74055 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407998 75132 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 75132 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407971 140210 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 140210 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44370713 50744 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 50744 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
44305816 162457 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 162457 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
44408051 140683 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 140683 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
21041073 138307 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 138307 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
9829083 119621 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 119621 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2102 1162 17 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
5311057 1162 17 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
CHEMBL441225 1162 17 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
44407906 74344 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 74344 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 74409 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 74409 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407907 75330 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 75330 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408025 75547 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 75547 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407917 96097 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 96097 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44407903 140178 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 140178 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44407902 75058 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 75058 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44408046 140200 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 140200 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
104943 55084 34 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55084 34 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44407972 140212 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 140212 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44370530 48843 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 48843 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
44307819 102110 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102110 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 168687 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 168687 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 196988 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 196988 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307757 201833 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 201833 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 202066 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202066 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57394644 68008 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 68008 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10032981 106257 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 106257 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10055415 106261 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106261 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
118718516 114849 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 114849 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9939040 4926 5 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 4926 5 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44307679 201814 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 201814 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 201931 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 201931 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 68009 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 68009 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10395494 106259 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 106259 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
9832198 106260 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106260 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384380 59496 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL172794 59496 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44383617 155149 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL405167 155149 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10395612 106252 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 106252 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9801487 205260 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 205260 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
52937467 62179 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 62179 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44307898 199778 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 199778 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10418001 106258 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 106258 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL439284 212073 18 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
44307758 201853 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 201853 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391133 68010 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68010 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
10350454 106236 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106236 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 106262 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106262 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44383164 165146 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL424567 165146 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL3349620 209690 8 None - 0 Guinea pig 5.7 pKd = 5.7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718517 114850 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 114850 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44407901 139901 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 139901 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
52937271 62177 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 62177 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
132837 2198 51 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 2198 51 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 2198 51 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
52937273 62175 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 62175 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
10145229 9068 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9068 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
10349900 106254 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106254 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10350528 106238 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106238 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384379 129112 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL367312 129112 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL170299 207090 0 None - 0 Guinea pig 6.4 pKd = 6.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44408048 140015 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 140015 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
10259370 106253 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 106253 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10506928 119700 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 119700 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44383616 167987 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL435717 167987 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10325464 119616 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 119616 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44307821 101631 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 101631 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44337201 108112 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108112 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
107686 3315 37 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 3315 37 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 3315 37 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
52937270 62176 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 62176 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44408033 74408 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 74408 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44408047 96307 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 96307 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
15887537 108546 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 108546 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
21121353 100990 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 100990 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
57392804 67627 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67627 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67627 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57403249 71150 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911968 71150 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1962728 71150 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67626 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67626 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
52933155 67630 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911970 67630 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 67627 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67627 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67627 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67626 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67626 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 67627 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 67627 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 67627 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57398076 67629 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911969 67629 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67626 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67626 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 67626 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 67626 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
2096 3574 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2096 3574 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3574 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
25078100 3574 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3575 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
16131028 3575 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3575 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2097 3575 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 3575 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 3575 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2096 3574 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 3574 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
135413536 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 444 80 None -3 2 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
30699 215959 0 None -1 14 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
10328936 1511 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2086 1511 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2955 1511 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL373569 1511 28 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
135413538 1641 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
4470 1641 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
7623 1641 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1199324 1641 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB06717 1641 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
2096 3574 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
25078100 3574 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
2088 2137 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
45749 2137 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2101 3628 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
155817436 2743 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2092 2743 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
107686 3315 37 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
3522 3315 37 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
CHEMBL131171 3315 37 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
10328936 1511 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2086 1511 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2955 1511 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
CHEMBL373569 1511 28 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3849 3133 0 None - 1 Rat 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9243521
135413538 1641 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
4470 1641 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
7623 1641 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1199324 1641 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB06717 1641 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
108167 2803 5 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
2107 2803 5 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
CHEMBL1178725 2803 5 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
17268 3056 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2094 3056 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
10349 2211 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
9809077 2211 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
CHEMBL4303434 2211 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
3850 3417 0 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3086681 2231 14 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
3510 2231 14 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
CHEMBL42407 2231 14 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
2110 2910 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
219077 2910 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
3480 2910 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
CHEMBL346178 2910 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
DB04872 2910 33 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
2100 3627 0 None - 1 Human 6.4 pIC50 None 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2091 2745 0 None -223 2 Human 6.5 pIC50 None 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2099 3626 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2103 1605 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
6437864 1605 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
132629 2197 10 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
2104 2197 10 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
CHEMBL24999 2197 10 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
168489 3055 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2093 3055 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2109 4060 3 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
9852253 4060 3 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
CHEMBL129683 4060 3 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
132837 2198 51 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 2198 51 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 2198 51 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
2098 3625 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
36511 3625 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3805 3625 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3835 3625 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 3625 31 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL384518 210571 9 None - 0 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
CHEMBL428532 211697 6 None - 0 Guinea pig 8.8 pEC50 = 8.8 Binding
Compound was evaluated for effective dose against Muscular receptor in guinea pig ileumCompound was evaluated for effective dose against Muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
44337561 96277 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL264395 96277 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308430 101780 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL303222 101780 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 208372 0 None - 0 Guinea pig 5.9 pEC50 = 5.9 Binding
Compound was evaluated for effective dose against neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
CHEMBL263185 208806 4 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
CHEMBL415159 211417 4 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44337560 109249 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL323028 109249 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337787 9062 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL110177 9062 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308431 163959 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL421485 163959 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 208372 0 None - 0 Guinea pig 8.7 pEC50 = 8.7 Binding
Compound was evaluated for effective dose against muscular receptor in guinea pig ileumCompound was evaluated for effective dose against muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
132629 2197 10 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
2104 2197 10 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL24999 2197 10 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL422779 211555 0 None - 0 Guinea pig 8.5 pEC50 = 8.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
CHEMBL106184 206718 0 None - 0 Guinea pig 6.5 pEC50 = 6.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(CCCN)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
108147 3513 29 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
2127 3513 29 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL106124 3513 29 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL428532 211697 6 None - 0 Guinea pig 8.4 pEC50 = 8.4 Binding
Compound was evaluated for effective dose against Neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against Neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
10843656 96361 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
CHEMBL265115 96361 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
44337775 162843 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL419558 162843 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337797 108514 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL321228 108514 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308550 101635 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL302349 101635 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
162673403 182457 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4794099 182457 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
44337530 167323 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL431243 167323 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
162651127 179691 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4750714 179691 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
11238415 98784 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL281797 98784 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
11352855 96656 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL26761 96656 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9821217 107231 17 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL319118 107231 17 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3215877 107231 17 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
49863731 15142 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15142 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
25129133 188290 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188290 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 188290 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188290 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
25129133 188290 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 188290 0 None 102 5 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
46884430 8221 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8221 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11852872 68270 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68270 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
25027805 70663 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951813 70663 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
44178113 60920 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 60920 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
57391771 70661 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 70661 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395695 71263 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917866 71263 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963416 71263 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
87318292 125918 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 125918 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
67232184 125912 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 125912 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
73265457 125917 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 125917 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11248796 161088 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL413027 161088 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
122182823 121534 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596448 121534 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433804 146250 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146250 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
73265450 125908 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 125908 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
73265453 125913 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 125913 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
57402264 70601 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951626 70601 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57403992 70608 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951633 70608 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
73265456 125916 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 125916 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
9828716 71274 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917853 71274 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963487 71274 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
127944 120399 2 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL356062 120399 2 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL555572 120399 2 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
46881682 7998 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 7998 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46883879 7673 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7673 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57398784 70606 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951631 70606 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
57400919 71260 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917856 71260 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963413 71260 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57397000 70662 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951811 70662 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
11621512 70605 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951630 70605 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57397022 70607 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951632 70607 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265454 125914 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 125914 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
57400917 71288 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917852 71288 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963577 71288 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
135539114 206551 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
CHEMBL99055 206551 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
122182821 121532 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596446 121532 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
122182822 121533 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596447 121533 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433798 145141 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145141 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433797 145591 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 145591 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6450 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6450 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135539114 206551 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
CHEMBL99055 206551 2 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
57398783 70604 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951629 70604 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
57391771 70661 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 70661 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395688 68268 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917851 68268 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57390405 71262 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917865 71262 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963415 71262 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57397483 71261 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917859 71261 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963414 71261 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400921 71249 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917860 71249 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963300 71249 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57395693 71250 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917862 71250 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963301 71250 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456802 96988 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270090 96988 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
16663280 97499 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272649 97499 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
23653789 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
46881727 5503 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5503 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8350 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8350 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8809 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8809 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8809 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8809 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52949827 17145 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17145 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
25028925 90920 2 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 90920 2 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
16663280 97499 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
16663280 97499 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 97499 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 97499 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
23653789 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
44444666 153838 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL398720 153838 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
127944 120399 2 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL356062 120399 2 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL555572 120399 2 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
46947062 17263 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17263 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57391807 70602 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951627 70602 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
24889113 7851 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7851 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7851 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52943848 17223 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17223 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
73265455 125915 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 125915 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2098 3625 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3625 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3625 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3625 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3625 31 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
135406581 31696 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
CHEMBL140745 31696 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
44433800 146244 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 146244 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433803 146249 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 146249 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 6450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6450 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881820 7465 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7465 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881729 7842 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7842 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 8350 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8350 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444634 93654 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249145 93654 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
24180495 154132 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399668 154132 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444643 154350 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400848 154350 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
135406581 31696 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
CHEMBL140745 31696 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
73265452 125911 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 125911 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11852872 68270 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 68270 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402266 70609 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951634 70609 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265451 125910 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 125910 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
11409185 98951 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 98951 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
57402690 68267 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917850 68267 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
9917079 60822 33 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 60822 33 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
5752 3930 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
6918331 3930 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
CHEMBL522302 3930 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
DB12436 3930 20 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
71456209 78232 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL2112366 78232 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
46881729 7842 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7842 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 7916 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7916 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750888 8351 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8351 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752434 9030 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9030 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52941351 17181 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17181 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57395691 71289 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917858 71289 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963578 71289 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400923 71264 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917867 71264 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963417 71264 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10407571 167383 8 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL431690 167383 8 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
57397481 71295 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917855 71295 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963613 71295 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
11983278 165536 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
CHEMBL425956 165536 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
11983278 165536 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
CHEMBL425956 165536 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
135449286 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
135485796 35009 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL143587 35009 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
135449286 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
CHEMBL52330 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
44407331 140669 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382848 140669 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
135413536 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
230 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
3490 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
6918365 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
CHEMBL1471 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
DB00673 444 80 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
44433799 88226 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 88226 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
135449286 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL52330 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
24888943 7850 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 7850 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 7916 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 7916 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 7916 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7916 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46881682 7998 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 7998 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947645 17046 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17046 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17110 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17110 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993313 186438 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 186438 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444631 93653 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249144 93653 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
44444637 94052 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251577 94052 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444685 154222 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154222 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
135547943 34189 21 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
CHEMBL142819 34189 21 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
135449286 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
CHEMBL52330 192576 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
135413536 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
230 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
3490 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
6918365 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
CHEMBL1471 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
DB00673 444 80 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
42611207 124253 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 124253 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
57399171 68269 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917857 68269 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57398782 70596 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951621 70596 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
135413536 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
230 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
3490 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
6918365 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
CHEMBL1471 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
DB00673 444 80 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
135539114 206551 2 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
CHEMBL99055 206551 2 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
135419433 31565 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL140626 31565 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
44407427 140636 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL382803 140636 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44318589 162779 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL419119 162779 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094861 204085 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83250 204085 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094863 106638 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL316141 106638 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
57393955 71238 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917863 71238 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963216 71238 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46830287 7893 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 7893 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993314 170462 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 170462 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44444664 94029 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251387 94029 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
73265449 123880 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 123880 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
10051762 81803 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21709 81803 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44407513 73933 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202417 73933 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
10004377 110907 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327250 110907 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44325058 111947 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329828 111947 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL1651026 207073 19 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cellsDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL1651026 207073 19 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting methodDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting method
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.11.014
57398785 70610 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951635 70610 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
24889113 7851 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7851 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7851 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884518 7881 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 7881 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884467 7894 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7894 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 7916 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7916 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884519 7994 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 7994 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
52943994 17635 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17635 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993955 183713 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 183713 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444681 93924 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 93924 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444688 154453 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL401415 154453 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444658 166500 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL428933 166500 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
45271306 193989 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193989 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2098 3625 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
36511 3625 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3805 3625 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3835 3625 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
CHEMBL235363 3625 31 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
2098 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
36511 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3805 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3835 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
CHEMBL235363 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
2098 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274207 78148 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
CHEMBL21122 78148 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
10053419 82194 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21792 82194 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44412226 168260 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL437878 168260 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44433789 145589 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 145589 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44444646 93574 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248748 93574 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444693 94048 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251557 94048 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444650 154351 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
CHEMBL400849 154351 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
2098 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
36511 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3805 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3835 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
CHEMBL235363 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
2098 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
36511 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3805 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3835 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL235363 3625 31 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL389652 210673 0 None 2 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44334114 4463 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
CHEMBL102382 4463 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
44295002 155409 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL406136 155409 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44407325 73002 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
CHEMBL201362 73002 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
57390403 71296 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917861 71296 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963614 71296 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46881728 5504 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5504 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881821 5509 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5509 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884516 7729 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 7729 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
42639650 187602 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 187602 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444684 93835 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL250390 93835 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
44444695 94088 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251768 94088 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44274251 82735 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21831 82735 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10053174 99035 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL283318 99035 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412207 139789 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380680 139789 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
9821217 107231 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL319118 107231 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL3215877 107231 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
9821217 107231 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL319118 107231 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL3215877 107231 17 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
57403991 70600 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951625 70600 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
44456522 158326 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL409520 158326 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
22885694 140903 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384177 140903 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24888772 7919 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 7919 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752434 9030 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9030 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947646 17048 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 17048 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52942803 17049 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17049 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44444669 153869 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL398919 153869 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
10186401 98457 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
CHEMBL279442 98457 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
24889114 7654 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 7654 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46884515 7728 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 7728 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884472 7898 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 7898 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993312 178763 10 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 178763 10 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444638 155105 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL404855 155105 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
3086681 2231 14 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2231 14 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2231 14 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44333730 107173 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL319046 107173 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
10098209 98619 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL280662 98619 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
57400915 71259 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917844 71259 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963412 71259 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44416078 139595 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL380210 139595 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
16006943 140900 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384171 140900 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884473 7692 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 7692 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883823 8332 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8332 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52948931 17052 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17052 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
44444660 154097 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399466 154097 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444685 154222 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 154222 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
44444692 154924 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL404001 154924 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44593632 178182 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
CHEMBL468830 178182 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
44177570 60916 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60916 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10460917 163186 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL420543 163186 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
2102 1162 17 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
5311057 1162 17 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
CHEMBL441225 1162 17 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
73352606 92527 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441368 92527 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
10460917 163186 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163186 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
57402689 68265 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917845 68265 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
23146876 70598 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951623 70598 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44433802 146246 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 146246 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44433804 146250 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 146250 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
22885615 79755 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213538 79755 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
52947645 17046 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17046 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52947647 17050 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17050 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44233185 193144 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193144 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
57397021 70599 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951624 70599 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
46884471 7652 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 7652 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7672 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7672 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24888942 7849 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 7849 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883824 8333 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 8333 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44444640 93533 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248545 93533 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444694 154275 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL400393 154275 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9850771 119360 2 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119360 2 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
15253734 164786 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL423623 164786 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
46227362 200888 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200888 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274166 79826 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL21385 79826 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
44412236 77770 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210365 77770 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
22885699 80593 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215373 80593 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885703 140882 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL384112 140882 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44357006 13598 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL1195055 13598 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL553778 13598 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
44356378 25523 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL135263 25523 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10480465 206663 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99792 206663 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9892852 83946 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL22194 83946 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
24785717 121578 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 121578 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
18669097 98930 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL282725 98930 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
57402692 71251 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917869 71251 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963302 71251 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402221 70664 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951814 70664 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
22885697 141128 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385463 141128 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44433394 146113 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL392368 146113 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
2102 1162 17 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
5311057 1162 17 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
CHEMBL441225 1162 17 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
9892852 83946 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL22194 83946 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10553959 187277 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL49638 187277 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
104943 55084 34 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
CHEMBL16192 55084 34 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
9796216 101760 13 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
CHEMBL303118 101760 13 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
44294293 187859 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50270 187859 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10098209 98619 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL280662 98619 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
57402265 70603 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951628 70603 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
44433797 145591 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 145591 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
52948868 17051 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 17051 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
46883879 7673 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 7673 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44593636 181028 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181028 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
11814040 78384 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112743 78384 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
9871891 5371 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107482 5371 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
9871891 5371 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
CHEMBL107482 5371 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
11318556 93488 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93488 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9871414 98527 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
CHEMBL279977 98527 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
44274253 171701 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL447473 171701 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
10099787 103024 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085129 103024 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10480465 206663 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99792 206663 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412245 77588 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL209657 77588 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44444689 93777 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 93777 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
24755076 91138 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
CHEMBL240706 91138 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
44412445 77551 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
CHEMBL209456 77551 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
135405092 138740 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL379137 138740 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
3086681 2231 14 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
3510 2231 14 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
CHEMBL42407 2231 14 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
10257218 24620 2 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL134500 24620 2 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10460917 163186 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163186 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5322 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5322 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10101238 34603 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143156 34603 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 207073 19 None - 1 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2013.03.016
44407370 74087 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL202775 74087 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
22885698 138802 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL379289 138802 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44444629 93652 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249143 93652 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9871754 5322 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5322 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
5757 3911 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
9832383 3911 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
CHEMBL522987 3911 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
DB11949 3911 10 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
58993578 121579 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596493 121579 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
9891865 79632 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212991 79632 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
22885692 79753 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213515 79753 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44415869 80266 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215147 80266 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885691 80890 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL215889 80890 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
10951720 78382 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112741 78382 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10369373 161399 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL415705 161399 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
24992986 183712 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 183712 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44294659 103026 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085131 103026 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9869697 64295 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817895 64295 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
10341570 120548 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 120548 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3625 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
36511 3625 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3805 3625 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3835 3625 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL235363 3625 31 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44274153 77512 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL20937 77512 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
135529973 120983 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL358343 120983 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
44407459 140567 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382720 140567 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44456524 97476 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272569 97476 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44416008 80076 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214748 80076 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884470 7897 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 7897 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752568 8809 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8809 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
18407037 161697 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL416372 161697 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
18407037 161697 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL416372 161697 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412173 77843 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210630 77843 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44456700 95450 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL259251 95450 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415789 141121 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385414 141121 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10144275 18690 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128369 18690 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
22293490 100827 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL296583 100827 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
24785717 121578 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 121578 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
44356404 22990 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
CHEMBL133140 22990 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
18669091 4602 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103367 4602 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10008129 60737 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL176500 60737 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9938284 100932 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL297344 100932 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11755227 201378 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63793 201378 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
71450870 78234 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL2112368 78234 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
22885695 138581 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378689 138581 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
46881600 7012 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 7012 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44444689 93777 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 93777 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444671 154206 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400060 154206 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
57402688 71247 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917843 71247 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963298 71247 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
52941489 17534 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17534 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10768417 165039 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL424291 165039 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 207073 19 None - 1 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
58993533 121571 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596485 121571 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
19797422 96202 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL263795 96202 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
104943 55084 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL16192 55084 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
10346229 82595 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21813 82595 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
21955317 103025 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085130 103025 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44412374 77426 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
CHEMBL209240 77426 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
11678857 138764 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL379224 138764 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44456865 97441 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272469 97441 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
14986135 162837 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
CHEMBL419500 162837 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
44334275 4988 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL105420 4988 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
9871754 5322 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5322 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10415870 103022 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085127 103022 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10483816 190594 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL51893 190594 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
10483816 79205 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115007 79205 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10415870 140065 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL381390 140065 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
53379508 66113 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817891 66113 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852123 66113 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
22885696 138386 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378416 138386 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44444654 93610 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248943 93610 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15516313 178130 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL468350 178130 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
44593636 181028 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 181028 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
9871754 5322 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 5322 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
10698096 55568 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL162337 55568 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9871754 5322 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5322 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
44334149 4516 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102730 4516 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10393962 103027 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085132 103027 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
22293475 186535 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 186535 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
18782542 110964 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL327606 110964 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
11146618 78383 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
CHEMBL2112742 78383 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
104943 55084 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55084 34 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44346234 14463 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL120523 14463 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
10415534 165642 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL426577 165642 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2098 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
36511 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3805 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3835 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL235363 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
22885704 81099 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL216018 81099 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24752568 8809 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 8809 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752568 8809 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8809 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444659 93725 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249568 93725 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9855000 20406 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20406 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
18669080 4924 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105047 4924 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10210026 100877 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296979 100877 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
58993465 121580 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596494 121580 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
22885702 80081 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214761 80081 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884434 7828 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 7828 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44346438 114239 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL333882 114239 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
10098987 59651 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59651 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55084 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
CHEMBL16192 55084 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
104943 55084 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
CHEMBL16192 55084 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
44410317 76782 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207794 76782 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415921 141203 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385925 141203 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889458 8330 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 8330 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46947062 17263 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17263 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17263 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17263 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
9821217 107231 17 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL319118 107231 17 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL3215877 107231 17 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 181850 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 181850 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44577989 188830 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL513351 188830 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
9984665 5255 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL106864 5255 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
104943 55084 34 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55084 34 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2098 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
36511 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3805 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3835 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
CHEMBL235363 3625 31 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
44412493 77526 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
CHEMBL209407 77526 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
44415909 79461 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212349 79461 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
49863732 15143 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15143 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
135430679 45770 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
CHEMBL153310 45770 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
44294660 103028 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085133 103028 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
53379509 66108 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817892 66108 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852099 66108 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
44433789 145589 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 145589 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24750888 8351 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 8351 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135430775 45074 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152685 45074 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44412235 139632 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380388 139632 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44415808 81035 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215975 81035 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
11756257 167209 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43044 167209 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
18669059 98302 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL278149 98302 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412373 138557 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
CHEMBL378663 138557 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
21955285 188397 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50867 188397 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
104943 55084 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55084 34 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
24785978 121569 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 121569 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
9329 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9894349 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
CHEMBL339486 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9329 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
10392469 193176 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 193176 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44177669 60917 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60917 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10325507 60106 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL175224 60106 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44444674 93876 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250596 93876 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44408291 140336 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL381984 140336 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408177 140431 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL382331 140431 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408290 140705 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL383048 140705 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
10007758 178393 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL47070 178393 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
104943 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL16192 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227363 197974 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197974 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44412453 161128 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL413279 161128 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
21955222 101300 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL300014 101300 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10392469 193176 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL539928 193176 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
2102 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
5311057 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
CHEMBL441225 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
10098987 59651 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59651 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10720240 34855 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143375 34855 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
2102 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
5311057 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL441225 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
104943 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL16192 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
2102 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
5311057 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
CHEMBL441225 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
2102 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
5311057 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
CHEMBL441225 1162 17 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
105083 25232 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL135022 25232 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
44410278 140320 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381965 140320 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44408176 73959 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL202439 73959 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
104943 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL16192 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44593634 182197 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL479049 182197 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
10099939 4903 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 4903 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 106850 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 106850 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 4903 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 4903 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
CHEMBL16192 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
104943 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
CHEMBL16192 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
10814682 205970 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL95626 205970 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44433798 145141 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 145141 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
46884468 7895 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 7895 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
104943 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL16192 55084 34 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44415896 138372 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378331 138372 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44299271 194364 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL56038 194364 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
42639649 170168 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 170168 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44334107 4324 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL101421 4324 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44299271 194364 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56038 194364 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10814682 205970 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL95626 205970 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412159 140377 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL382255 140377 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
46884430 8221 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 8221 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
22901329 98609 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL28055 98609 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
9805809 102600 6 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
CHEMBL307488 102600 6 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
44334127 4551 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102937 4551 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44415554 138507 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378609 138507 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
136094860 204381 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85792 204381 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44433796 89747 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL238220 89747 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44444677 154432 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL401281 154432 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44312057 202737 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL72234 202737 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
24785978 121569 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 121569 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10392925 14297 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120081 14297 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10076669 59887 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174016 59887 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11800025 120754 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL357887 120754 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
18669082 165152 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL424586 165152 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669082 165152 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL424586 165152 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL2115376 207513 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
2102 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
5311057 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL441225 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44410191 140148 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381555 140148 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415947 79878 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214118 79878 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24750734 7916 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 7916 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 7916 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7916 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
2102 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
5311057 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL441225 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
44305288 201181 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62649 201181 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10392925 14297 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120081 14297 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
18686789 92528 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441369 92528 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
136094778 138718 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
CHEMBL379010 138718 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
10357939 117563 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL340559 117563 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
44294291 100707 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL295685 100707 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408158 139636 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL380408 139636 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
56662745 64297 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64297 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64297 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10258336 100799 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296397 100799 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44307416 201310 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63240 201310 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10258336 100799 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296397 100799 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44456703 157797 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408960 157797 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
2102 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
5311057 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
CHEMBL441225 1162 17 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
2098 3625 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
36511 3625 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3805 3625 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3835 3625 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 3625 31 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
44412225 139166 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL379816 139166 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44407431 72867 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
CHEMBL201192 72867 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
10076383 100743 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL296013 100743 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
104943 55084 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL16192 55084 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
44408313 74138 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL202884 74138 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
52941550 17607 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 17607 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
104943 55084 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL16192 55084 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44433784 89745 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238210 89745 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44416136 79382 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212025 79382 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
9855000 20406 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20406 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
10347274 128138 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL366818 128138 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55084 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
CHEMBL16192 55084 34 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
21955298 79204 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115006 79204 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL396426 210739 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44415967 138159 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL377917 138159 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46947062 17263 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17263 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10502796 32083 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL141034 32083 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44578024 178107 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL468163 178107 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
10372941 118990 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
CHEMBL345520 118990 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
10885893 102426 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL306089 102426 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10553959 187277 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL49638 187277 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44305221 100546 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL294545 100546 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10553959 187277 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL49638 187277 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44313273 203251 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL76501 203251 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44433793 147840 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393746 147840 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL396426 210739 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
22293505 188928 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL51417 188928 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
25028925 90920 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 90920 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
44358731 30111 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139167 30111 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10077113 121016 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 121016 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 55084 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 55084 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
22293475 186535 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 186535 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415444 79797 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213726 79797 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
52949827 17145 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 17145 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 7916 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7916 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL229280 207703 0 None 23 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44333607 4891 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL104883 4891 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10142159 81118 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21607 81118 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
44274180 162628 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL418186 162628 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
44433787 88090 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235219 88090 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
11800024 206506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98811 206506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
136180340 119091 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL346447 119091 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10053205 116072 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 116072 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11800024 206506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98811 206506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44408123 140044 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL381362 140044 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
46881682 7998 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 7998 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
104943 55084 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 55084 34 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10578351 119710 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL352176 119710 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
71449072 78153 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 78153 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
56668401 66095 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817890 66095 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852009 66095 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415404 79616 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212931 79616 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10721713 119519 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350381 119519 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
18709649 164443 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42259 164443 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44415550 165572 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL426145 165572 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881820 7465 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 7465 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44433792 147838 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393745 147838 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
22901329 98609 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28055 98609 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
22901329 98609 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL28055 98609 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44294689 101129 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL298858 101129 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11016806 203239 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL76455 203239 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
9829083 119621 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 119621 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10816374 18692 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128384 18692 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
132846 96985 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL1256740 96985 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL27006 96985 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
132846 96985 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL1256740 96985 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL27006 96985 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
135547943 34189 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL142819 34189 21 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
44456828 97118 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270751 97118 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44358610 29255 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138463 29255 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 119833 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 119833 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
18669087 98264 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL277880 98264 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669087 98264 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL277880 98264 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44325035 111648 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329018 111648 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44415400 79668 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213134 79668 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
9938657 59891 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 59891 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
10502796 32083 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL141034 32083 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
11799022 4386 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL101763 4386 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881727 5503 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 5503 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
15549737 178228 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL469176 178228 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 181850 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 181850 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44578056 189155 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL515935 189155 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
19797472 118244 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
CHEMBL341863 118244 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
10341570 120548 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 120548 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 3625 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3625 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3625 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3625 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3625 31 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
58993655 121572 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596486 121572 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
24752434 9030 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9030 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL2370435 208094 0 None 48 2 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
15639110 167568 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL433020 167568 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44274544 81100 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21602 81100 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44328469 111735 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL329090 111735 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
24782914 121568 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596482 121568 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884431 7957 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 7957 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10578269 34905 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143464 34905 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
4898 2714 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
5742 2714 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
6451149 2714 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
CHEMBL206253 2714 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
DB09048 2714 78 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
10047566 164678 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL422931 164678 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10047566 164678 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL422931 164678 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415840 79541 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212663 79541 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10049890 79587 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 79587 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10047566 164678 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL422931 164678 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL389652 210673 0 None 2 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11813209 203379 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL77684 203379 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
18669072 82890 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21909 82890 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
10576865 206376 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98022 206376 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44433810 89435 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237796 89435 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
9959724 164292 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42191 164292 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10531050 119833 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 119833 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
489662 82600 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL21815 82600 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
132846 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
CHEMBL1256740 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
CHEMBL27006 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
44297605 193010 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL53312 193010 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132846 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL1256740 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL27006 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
9805809 102600 6 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL307488 102600 6 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
44338517 6243 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108200 6243 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9938657 59891 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 59891 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
132846 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL1256740 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL27006 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
44346206 113149 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL332284 113149 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
132846 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL1256740 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL27006 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
10047567 205479 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL92701 205479 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
9890435 96981 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL27003 96981 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
132846 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL1256740 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL27006 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
2102 1162 17 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
5311057 1162 17 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL441225 1162 17 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
44458328 99041 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL283356 99041 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
11799022 4386 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL101763 4386 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL1256740 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL27006 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 99041 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 99041 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44346206 113149 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL332284 113149 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576865 206376 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98022 206376 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10648551 206675 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99873 206675 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL1256740 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL27006 96985 21 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
489662 82600 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21815 82600 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
489662 82600 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21815 82600 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10648551 206675 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99873 206675 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
24799545 86979 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333621 86979 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44407321 74043 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202568 74043 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410193 139791 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL380684 139791 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
44297605 193010 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
CHEMBL53312 193010 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
44456580 154735 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL402895 154735 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24889111 7827 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 7827 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17046 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17046 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 17110 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 17110 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943994 17635 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 17635 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10047566 164678 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL422931 164678 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44458328 99041 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL283356 99041 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
46227361 200887 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200887 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL389652 210673 0 None -2 4 Rat 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44335318 5021 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 5021 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44312285 102471 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 102471 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10047566 164678 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL422931 164678 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
71450941 79094 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 79094 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44305248 201189 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 201189 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
9805809 102600 6 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 102600 6 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
2098 3625 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
36511 3625 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3805 3625 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3835 3625 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
CHEMBL235363 3625 31 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
10837742 185273 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL48680 185273 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
44318685 204274 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84881 204274 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44408124 75035 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL203961 75035 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
58993471 121570 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596484 121570 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
58993453 121574 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
CHEMBL3596488 121574 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
56662745 64297 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64297 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64297 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415415 78552 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211304 78552 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884469 7896 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 7896 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
46881779 8350 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8350 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306210 101904 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303896 101904 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335372 4691 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 4691 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10414428 4769 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
CHEMBL104301 4769 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
44358603 118527 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342662 118527 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9959330 193874 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL554713 193874 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2098 3625 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 3625 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 3625 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 3625 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3625 31 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
10578969 56915 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL165007 56915 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10626048 118052 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341599 118052 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
490428 119058 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119058 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44294535 103023 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL3085128 103023 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
24801458 86982 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333624 86982 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
44407422 140820 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL383743 140820 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410281 75202 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL204573 75202 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993670 121575 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
CHEMBL3596489 121575 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
57399170 71294 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917842 71294 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963612 71294 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456650 154944 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL404089 154944 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
52941570 17047 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 17047 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943848 17223 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 17223 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10052312 106893 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL317896 106893 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44338545 9230 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111176 9230 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9916428 112335 1 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL330888 112335 1 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
10793838 119568 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350846 119568 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9892852 83946 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 83946 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9890435 96981 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL27003 96981 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
44333692 4474 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102434 4474 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44270505 12245 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1185492 12245 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL417263 12245 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
9890435 96981 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
CHEMBL27003 96981 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
9890435 96981 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL27003 96981 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318605 204141 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83772 204141 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44456894 159979 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL411242 159979 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10049890 79587 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 79587 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
22885690 141239 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL386151 141239 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
52942803 17049 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 17049 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
11756839 5112 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL106087 5112 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9892852 83946 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL22194 83946 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
44358676 29782 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138890 29782 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9850771 119360 2 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119360 2 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9892852 83946 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL22194 83946 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44368171 45128 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152742 45128 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10460917 163186 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 163186 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 5322 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5322 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11568372 204296 3 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 204296 3 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44318672 204360 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85626 204360 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
57390401 71248 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963299 71248 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3216988 71248 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44415986 79959 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214472 79959 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889113 7851 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7851 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7851 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881728 5504 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 5504 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44335319 107011 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 107011 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44370448 119241 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL347891 119241 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358604 28294 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL137609 28294 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44358732 31021 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140124 31021 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358428 118491 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342607 118491 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9871754 5322 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5322 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
2098 3625 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
36511 3625 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3805 3625 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3835 3625 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3625 31 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2098 3625 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
36511 3625 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3805 3625 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3835 3625 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
CHEMBL235363 3625 31 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
136180339 120578 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL357303 120578 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10027219 99108 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 99108 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44274412 75670 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
CHEMBL20572 75670 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
44410283 137761 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL377091 137761 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
22293475 186535 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 186535 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408295 139782 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL380651 139782 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
2098 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
36511 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3805 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3835 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
CHEMBL235363 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
56662745 64297 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 64297 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 64297 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
2098 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
36511 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3805 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3835 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
CHEMBL235363 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
44456625 168357 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL438759 168357 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415403 138153 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL377881 138153 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
52941489 17534 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17534 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941506 17570 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 17570 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17263 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17263 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
71699792 124252 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 124252 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
19797432 37507 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37507 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10438671 27126 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136764 27126 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358707 31227 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL140299 31227 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
9850771 119360 2 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 119360 2 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10076881 162354 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 162354 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10627355 119492 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 119492 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44338518 7626 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108889 7626 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338359 162865 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL419742 162865 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
132629 2197 10 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
2104 2197 10 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
CHEMBL24999 2197 10 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
21050485 167391 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL431732 167391 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799366 86976 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333618 86976 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
10648288 101417 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL300856 101417 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
24785977 121542 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596456 121542 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
10414293 37205 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 37205 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
44396853 66922 7 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL188166 66922 7 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
21994307 26593 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136305 26593 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358471 29938 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139015 29938 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
132837 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
9461 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
CHEMBL22870 2198 51 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
10394703 193287 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54540 193287 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
135480369 33474 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
CHEMBL142216 33474 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
44274269 76663 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20717 76663 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
22293476 79203 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115005 79203 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
24889283 8331 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 8331 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
52948931 17052 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 17052 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
52941351 17181 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 17181 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44306310 101837 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303548 101837 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306023 101903 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303890 101903 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10100236 28586 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137887 28586 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358470 29699 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138825 29699 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358561 30247 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139286 30247 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
2098 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
36511 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3805 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3835 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 3625 31 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
10075595 60013 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174526 60013 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10554361 30630 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139719 30630 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10529338 31187 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL140263 31187 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10840066 116207 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL337358 116207 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541574 86969 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333611 86969 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44307181 202014 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67667 202014 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
58993542 121581 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596495 121581 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884432 7825 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 7825 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947647 17050 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 17050 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6450 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6450 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 7916 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 7916 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306218 162012 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL416864 162012 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44370973 46487 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL153976 46487 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44370354 120690 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
CHEMBL357757 120690 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
10462250 120866 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL358173 120866 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358720 28273 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137580 28273 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358657 30175 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139226 30175 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10816935 117591 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340732 117591 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
46881821 5509 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 5509 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
71541373 86983 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333625 86983 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800231 86995 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333637 86995 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785712 121577 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
CHEMBL3596491 121577 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
57393953 71256 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917849 71256 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963369 71256 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44415443 77566 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209531 77566 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415485 79485 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212439 79485 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415502 79612 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212919 79612 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884517 7993 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 7993 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 7672 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 7672 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 17046 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 17046 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 17263 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 17263 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 6450 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 6450 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
19797432 37507 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 37507 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10650469 57123 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165498 57123 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44328374 206238 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL97241 206238 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
11755361 116055 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL336439 116055 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
15639149 112397 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL331059 112397 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10413173 29430 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
CHEMBL138620 29430 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
44346149 15327 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL121742 15327 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346551 15391 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL122119 15391 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10359664 113490 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
CHEMBL332644 113490 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
54581461 60919 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60919 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
10254526 100017 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291025 100017 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44368083 44690 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152339 44690 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10457416 14702 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14702 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10098987 59651 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 59651 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
14986135 162837 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 162837 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44402934 70713 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 70713 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
44359091 31018 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
CHEMBL140123 31018 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
44346420 14175 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14175 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44318657 204193 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84090 204193 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL2371978 208417 0 None 30 3 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 55084 34 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 55084 34 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
18391045 99917 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290043 99917 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44288896 168410 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 168410 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
19098237 36875 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 36875 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44312056 203006 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 203006 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358585 31036 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL140134 31036 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
18709652 167712 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL434012 167712 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44306230 100275 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292799 100275 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44319057 204119 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 204119 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
19049350 98810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281940 98810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
19049350 98810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL281940 98810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19049350 98810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL281940 98810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
44346694 114299 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334072 114299 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44289443 168495 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43970 168495 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
44297749 192921 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52892 192921 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333579 4301 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101288 4301 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
44338510 8531 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL109514 8531 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44338531 9253 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111304 9253 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
44322648 204585 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87194 204585 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322525 204837 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88810 204837 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10095174 204927 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89385 204927 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44415470 165280 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424883 165280 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 7826 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 7826 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44294395 186602 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972677 186602 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL49233 186602 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15755315 162619 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
CHEMBL418124 162619 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
15755303 198654 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59768 198654 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755300 201279 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL63059 201279 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44337428 7140 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
CHEMBL108575 7140 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
10793341 108340 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
CHEMBL320989 108340 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
44411742 77885 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 77885 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
44344435 12960 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL119025 12960 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
2125 2969 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 2969 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 2969 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
44291515 100656 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 100656 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44291788 100929 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 100929 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44346650 113927 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
CHEMBL333308 113927 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
15755305 100503 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294288 100503 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755312 100578 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL294737 100578 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
15755330 201120 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62349 201120 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755295 201567 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64631 201567 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1190873 206841 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
CHEMBL541800 206841 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
10840399 9270 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL111384 9270 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
15755333 100098 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
CHEMBL291602 100098 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
15755331 100368 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293445 100368 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755294 201614 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64829 201614 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64601 214068 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10744888 108167 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
CHEMBL320762 108167 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
44337578 167513 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432620 167513 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
15485361 96768 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 96768 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10362340 89825 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23851 89825 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44274545 82085 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21775 82085 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44362598 36578 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145022 36578 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10362340 89825 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
CHEMBL23851 89825 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
44312026 102365 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL305608 102365 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44289232 169294 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL444043 169294 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 106254 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106254 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL2369600 207879 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10477952 98518 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL279916 98518 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
19797474 37223 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145552 37223 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44384902 59617 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 59617 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44362586 37503 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
CHEMBL145799 37503 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
44276673 96895 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 96895 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
44324705 111852 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329445 111852 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
44359056 118932 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL345069 118932 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
10039383 85038 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
CHEMBL22680 85038 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
44297603 162566 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417760 162566 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11683136 105310 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126963 105310 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44333708 162812 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL419352 162812 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
11489471 94426 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25398 94426 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10389968 59564 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173014 59564 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
21753663 194970 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56442 194970 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
71541576 86971 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333613 86971 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800927 86997 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333639 86997 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
44433783 89744 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238209 89744 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883823 8332 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 8332 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11705241 87793 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347857 87793 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
24993314 170462 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 170462 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44306115 201786 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL66151 201786 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324814 205466 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL92621 205466 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
44288901 162719 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL418697 162719 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11318556 93488 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 93488 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10840688 119683 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351940 119683 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44299464 198073 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59380 198073 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44306211 101853 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303680 101853 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
46884467 7894 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 7894 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10202046 120535 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 120535 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10407571 167383 8 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
CHEMBL431690 167383 8 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
44307162 201660 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL65153 201660 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
71583096 87778 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347694 87778 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
15755296 101800 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303337 101800 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755297 102173 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304472 102173 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10256518 96932 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL269781 96932 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
10363425 164045 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL421591 164045 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288846 167762 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43432 167762 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10317821 36543 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL144996 36543 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44358472 116282 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL337803 116282 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44294321 11930 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
54093758 11930 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL1183502 11930 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL301168 11930 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
15037921 119107 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346626 119107 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
68928842 124265 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 124265 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44312218 202430 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 202430 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10506929 56270 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 56270 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
44328416 206193 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL96956 206193 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
10039383 85038 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL22680 85038 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
19797452 121002 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL358529 121002 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44287503 99730 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL288340 99730 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44299829 197388 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL58774 197388 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44287541 159098 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41038 159098 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL449091 212200 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10692651 100607 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 100607 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
19003165 101691 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL302719 101691 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
3198 203792 73 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 203792 73 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 203792 73 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44297683 167616 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL433285 167616 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
9869033 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL290364 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
71541468 86991 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333633 86991 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801626 86998 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333640 86998 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
57403990 70595 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951620 70595 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
44335410 4916 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 4916 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44288885 99807 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
CHEMBL289026 99807 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
44396809 165803 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
CHEMBL427514 165803 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
44358709 29561 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL138715 29561 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44358679 29627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138770 29627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358680 116091 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336715 116091 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358683 118852 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
CHEMBL344434 118852 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
9869033 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL290364 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
9869033 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL290364 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
9910357 11859 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183052 11859 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL277524 11859 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44338638 5632 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107829 5632 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338546 108108 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL320535 108108 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
9917079 60822 33 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 60822 33 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
44346334 15061 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121094 15061 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10837362 30519 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL139558 30519 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44299969 195510 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56814 195510 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44359117 118815 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
CHEMBL344217 118815 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
44297491 193670 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55180 193670 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
76325557 105306 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126959 105306 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
76325558 105315 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126968 105315 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
490428 119058 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 119058 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
22293473 79207 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115009 79207 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24783682 121545 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596459 121545 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
11724403 167969 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL435564 167969 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
9852911 98911 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL282618 98911 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL2372525 208515 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
15118534 105696 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
CHEMBL3138259 105696 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
11445389 187797 10 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
CHEMBL501675 187797 10 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
44287211 159976 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41124 159976 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
16755229 173345 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL454087 173345 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
10435750 98786 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
CHEMBL281804 98786 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
10506124 100777 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL296228 100777 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10435750 98786 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
CHEMBL281804 98786 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
44312952 104903 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL311688 104903 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44322649 162807 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL419312 162807 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322524 204866 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL88998 204866 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44322704 204985 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89847 204985 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346399 161108 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL413108 161108 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
44322678 204825 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88731 204825 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346333 12930 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL1190061 12930 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL540060 12930 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10530444 119682 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL351922 119682 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44212284 59658 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL173420 59658 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
19797443 165048 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL424307 165048 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10439730 106262 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106262 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44346302 112589 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL331392 112589 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
11724403 167969 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 167969 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
44333821 4693 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL103984 4693 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44297293 170251 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL445357 170251 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44368118 118966 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL345315 118966 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
22859115 205491 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL92818 205491 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44334143 4491 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102569 4491 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
22859115 205491 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92818 205491 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
2090 2716 20 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 2716 20 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 2716 20 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
132961 141558 14 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL38824 141558 14 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
24801795 86987 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333629 86987 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44318405 105089 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL312202 105089 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
24784192 121557 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596471 121557 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44297912 193011 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL53314 193011 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44433786 146365 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392567 146365 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883824 8333 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 8333 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941570 17047 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 17047 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941550 17607 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 17607 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10251123 4754 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104225 4754 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44370893 119325 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL348594 119325 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
9869033 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 99945 3 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
71449177 79237 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL2115161 79237 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
71456198 78150 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL2112209 78150 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
44299583 101187 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL299275 101187 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19968650 168788 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
CHEMBL442028 168788 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
44319222 105650 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313546 105650 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44326280 97614 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
CHEMBL273302 97614 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
49799942 10431 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL1169534 10431 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44294194 176246 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
CHEMBL46103 176246 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
24783421 121549 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596463 121549 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
22850669 201288 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL63109 201288 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
22850669 201288 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL63109 201288 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44289169 101005 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 101005 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358649 28561 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137868 28561 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358611 28882 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
CHEMBL138130 28882 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
44358673 31233 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140303 31233 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44289169 101005 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL297883 101005 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297728 100283 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292874 100283 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294416 183375 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
74972686 183375 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48173 183375 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL406442 210851 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44458825 11870 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
54428149 11870 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1183194 11870 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL283990 11870 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
132961 141558 14 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
CHEMBL38824 141558 14 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
10364942 92909 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
CHEMBL24549 92909 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
71456210 78233 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
CHEMBL2112367 78233 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
10364942 92909 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
CHEMBL24549 92909 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
49863733 15144 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15144 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326290 205660 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL93909 205660 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44288789 100893 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297134 100893 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44386105 131395 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL369498 131395 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
10429546 98587 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL280422 98587 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
46227361 200887 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200887 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44289257 99873 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL289573 99873 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44289257 99873 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL289573 99873 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
44288789 100893 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL297134 100893 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL2369603 207881 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44306341 202041 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
CHEMBL67843 202041 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
10389745 100024 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291074 100024 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
76318227 105311 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126964 105311 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11612528 105322 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126974 105322 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44334112 4956 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105201 4956 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
44333950 107742 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
CHEMBL319700 107742 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
44276728 167468 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL432279 167468 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44299875 193110 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53846 193110 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274167 83023 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21991 83023 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
44276728 167468 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL432279 167468 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
56678621 66097 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817883 66097 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852017 66097 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44306004 13208 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL1192152 13208 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL543338 13208 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44306694 100324 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL293164 100324 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306354 201311 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
CHEMBL63249 201311 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
44312257 102424 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306065 102424 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358602 27087 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136734 27087 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358596 29038 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138269 29038 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
22293565 79279 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115449 79279 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
44303850 100587 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294798 100587 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44303793 198427 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59615 198427 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
68932793 124263 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642173 124263 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44337795 108075 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL320308 108075 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9978999 5395 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL107618 5395 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44324710 111844 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329416 111844 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
44358435 28491 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137792 28491 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44381056 57290 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL166816 57290 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44294376 11932 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
53927094 11932 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183513 11932 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL301946 11932 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
44294476 185616 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL48731 185616 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
132961 141558 14 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL38824 141558 14 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL264353 208863 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44346199 14117 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL119947 14117 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2369630 207890 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44358834 30352 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
CHEMBL139375 30352 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
44346199 14117 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL119947 14117 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
44433782 144922 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL391441 144922 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
9832198 106260 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106260 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
16214865 172691 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL452531 172691 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44346259 113605 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL332796 113605 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44346259 113605 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL332796 113605 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10767359 56193 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL163481 56193 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44368082 44664 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL152316 44664 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
44287609 99884 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 99884 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44274316 164852 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL423836 164852 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
56666212 64296 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817896 64296 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
52941489 17534 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17534 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL2112243 207476 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
21994365 25240 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL135028 25240 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358708 29560 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
CHEMBL138714 29560 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
44345148 10370 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL116535 10370 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44458598 98379 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL278849 98379 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
9954221 15343 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
CHEMBL121852 15343 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
44359025 28908 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL138150 28908 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44306435 96328 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL264821 96328 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44368326 172047 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL449347 172047 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44299750 193986 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55651 193986 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
10483816 190594 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL51893 190594 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10407571 167383 8 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL431690 167383 8 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
19797480 121019 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL358589 121019 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10409595 4706 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104075 4706 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44358473 31234 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
CHEMBL140304 31234 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
44358801 118451 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
CHEMBL342386 118451 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
14986146 44319 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152011 44319 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
44297488 193428 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54996 193428 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44297487 193598 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55129 193598 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10073370 59589 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL173120 59589 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10045010 89746 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23822 89746 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299854 100184 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL292237 100184 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
10041814 98405 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
CHEMBL279050 98405 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
10064734 122435 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
CHEMBL360815 122435 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
10041814 98405 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
CHEMBL279050 98405 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
1016 3678 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3678 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3678 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3678 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3678 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3678 75 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
44297424 190383 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51863 190383 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
2247 502 77 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 502 77 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 502 77 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 502 77 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 502 77 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
44358981 161111 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL413122 161111 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
44346319 112944 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL331925 112944 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
12096357 55893 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL162636 55893 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
44368158 121240 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL358932 121240 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11518191 105320 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126972 105320 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
76314660 105325 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126977 105325 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11489240 94833 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25639 94833 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10407571 167383 8 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL431690 167383 8 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321456 204955 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL89652 204955 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
104943 55084 34 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 55084 34 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
71541469 86992 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333634 86992 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44318658 104291 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL310896 104291 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44415540 141260 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL386258 141260 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71583094 87776 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347692 87776 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71452663 78118 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2112070 78118 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
11743207 4731 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104165 4731 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10342371 4860 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104737 4860 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44358710 29985 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139057 29985 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 119833 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 119833 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
118722856 115677 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358420 115677 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44321408 106526 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL315435 106526 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321408 106526 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL315435 106526 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15037920 45458 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 45458 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10531291 6480 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108304 6480 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44380707 120048 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL354564 120048 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
136056467 188602 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
49824386 188602 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL51135 188602 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44348660 117530 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL340394 117530 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
2812 4696 96 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4696 96 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44404006 132222 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
CHEMBL370013 132222 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
10439730 106262 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106262 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44297705 190279 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL51849 190279 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
71450949 79124 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL2114103 79124 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10055415 106261 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106261 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10344874 119632 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 119632 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
44386231 61036 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
CHEMBL176951 61036 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
15639102 114017 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL333566 114017 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
11433531 90683 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL23982 90683 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9933653 98538 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28003 98538 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
44299444 195503 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56811 195503 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
58993503 121561 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596475 121561 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44297858 155212 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL405820 155212 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
24992986 183712 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 183712 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
18654565 167355 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL431459 167355 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
10370818 162089 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL416983 162089 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44297708 193290 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54578 193290 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10834930 120974 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL358305 120974 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44213477 204020 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82692 204020 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
10369316 87782 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347702 87782 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44328401 112157 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL330362 112157 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
10835447 24516 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL134415 24516 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
71583093 87787 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347851 87787 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
15755313 101716 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL302844 101716 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
19797425 37169 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL145500 37169 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL64037 214065 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
46227360 200886 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200886 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44297680 100164 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292156 100164 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL265155 208883 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
122182824 121564 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596478 121564 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
56681948 66122 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817882 66122 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852159 66122 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44335466 4970 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL105295 4970 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44358783 30439 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
CHEMBL139471 30439 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
11192771 93887 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25065 93887 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9985523 98691 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL281200 98691 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
24799546 86980 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333622 86980 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
58993452 121536 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596450 121536 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44458786 11034 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178356 11034 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23096 11034 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
44349033 16595 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124532 16595 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
22869971 164705 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42306 164705 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
9981979 98688 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
CHEMBL281194 98688 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
44318349 204335 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL85414 204335 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44277742 100294 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL29293 100294 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44321457 167620 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL433336 167620 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
11633082 105309 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126962 105309 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10650263 25867 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 25867 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10501444 101394 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 101394 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
135890952 204367 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
CHEMBL85674 204367 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
11225834 98739 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL281491 98739 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
10364638 14474 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL120546 14474 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10094248 4703 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL104060 4703 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10006814 5156 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL106326 5156 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
44288548 100775 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL296213 100775 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44288790 169775 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL44474 169775 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
21994270 26872 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL136544 26872 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44312953 202842 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL72951 202842 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44359088 118266 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
CHEMBL342044 118266 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
178025 118635 4 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL342924 118635 4 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44305927 100133 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
CHEMBL291868 100133 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
44359111 118373 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL342260 118373 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
10364638 14474 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120546 14474 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346320 112945 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL331926 112945 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
44321442 204520 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL86806 204520 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44334098 5032 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105631 5032 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44321457 167620 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL433336 167620 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
9892852 83946 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 83946 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 99041 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 99041 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
44458983 99131 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL283989 99131 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
44458351 98918 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 98918 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44277478 166842 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
CHEMBL429610 166842 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
19797429 169873 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL444872 169873 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10745241 110029 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 110029 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369606 207884 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44338530 9252 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111303 9252 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322429 204531 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL86890 204531 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322610 204909 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89245 204909 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346330 14383 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL120441 14383 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
18669055 4527 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102811 4527 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
136180338 164623 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL422862 164623 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11757401 59616 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59616 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9892852 83946 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 83946 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44458328 99041 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 99041 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL281971 209092 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
44287803 99734 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 99734 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
25176461 86961 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333604 86961 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
25176462 86962 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333605 86962 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
58993541 121582 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596496 121582 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
136043848 77582 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209627 77582 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 7826 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 7826 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57565074 87780 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347696 87780 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2112240 207473 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44358495 115635 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL335788 115635 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10722491 119517 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
CHEMBL350366 119517 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
104943 55084 34 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL16192 55084 34 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL439019 212060 0 None 3 3 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44294519 103021 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085126 103021 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44407467 73600 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL202141 73600 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44415471 139017 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379707 139017 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46830287 7893 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 7893 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881729 7842 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7842 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 8809 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 8809 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1651026 207073 19 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of human tachykinin NK1 receptorInhibition of human tachykinin NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2010.07.034
44358727 26616 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136323 26616 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44359071 165109 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL424480 165109 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
44177670 60918 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60918 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44334108 4566 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103085 4566 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
135767968 45099 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
CHEMBL152716 45099 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
10457416 14702 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14702 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
490428 119058 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL346154 119058 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44299273 193136 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53901 193136 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
24782911 121562 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596476 121562 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
16663280 97499 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 97499 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
16663280 97499 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 97499 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10744602 56072 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163133 56072 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274277 80648 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21548 80648 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
56681950 66117 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817887 66117 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852130 66117 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415484 168361 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 168361 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884472 7898 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 7898 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947646 17048 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 17048 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948868 17051 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 17051 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
21994340 27797 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137255 27797 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
11800372 117750 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340931 117750 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL2370874 208184 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/S0960-894X(01)80229-8
44359094 33363 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
CHEMBL142121 33363 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
9927183 193922 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
CHEMBL55591 193922 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
136180337 120992 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL358437 120992 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
10834119 35388 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL143974 35388 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL405422 210804 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O 10.1021/jm00037a009
44294224 103019 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085124 103019 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9887525 189223 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL51648 189223 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44415392 140878 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384102 140878 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24889113 7851 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 7851 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 7851 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44358467 167667 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL433683 167667 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328394 205956 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95561 205956 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44319084 13570 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194867 13570 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553451 13570 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319321 13577 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194933 13577 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553554 13577 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
132837 2198 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
9461 2198 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL22870 2198 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL405209 210792 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
22293565 79202 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115004 79202 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
46881682 7998 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 7998 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11654898 87788 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347852 87788 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10369341 5662 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107848 5662 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9980171 9131 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL110679 9131 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
10506929 56270 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 56270 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
18407045 81691 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21662 81691 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL263852 208838 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O 10.1021/jm00037a009
23025481 64294 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817893 64294 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
57400460 70592 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951616 70592 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
57398780 70593 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951618 70593 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
46881779 8350 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 8350 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11561036 87789 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347853 87789 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
11539564 87790 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347854 87790 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL389651 210672 0 None 6 3 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
10369844 98866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL282290 98866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
24800578 86981 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333623 86981 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
44307417 201375 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63762 201375 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
57397020 70597 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951622 70597 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44456847 96990 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270114 96990 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415436 79534 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212644 79534 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415530 79706 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213316 79706 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415448 140896 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384157 140896 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881729 7842 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 7842 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10414293 37205 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 37205 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
71449143 79095 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113740 79095 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10603019 5158 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL106334 5158 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10369653 96339 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
CHEMBL264997 96339 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
10624372 202004 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67612 202004 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318640 204131 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83716 204131 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44410155 138746 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL379152 138746 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
24782912 121560 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596474 121560 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
44433800 146244 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 146244 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
21994327 26708 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136411 26708 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10815815 119543 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL350582 119543 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL387670 210654 0 None 109 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
44333964 5058 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105763 5058 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10837611 32010 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL140982 32010 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10669293 33210 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL141994 33210 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44274362 168614 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL440649 168614 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL2372518 208512 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
2102 1162 17 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
5311057 1162 17 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
CHEMBL441225 1162 17 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
44358767 26888 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136559 26888 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358741 30851 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139967 30851 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL2371977 208416 0 None 17 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11705830 105321 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126973 105321 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10318976 205550 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL93216 205550 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
44326306 111831 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL329325 111831 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44321442 204520 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL86806 204520 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
24800743 86975 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333617 86975 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
44433802 146246 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 146246 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44335376 4462 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL102376 4462 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44370369 48625 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL155976 48625 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44288951 100003 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290926 100003 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797419 164697 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL423019 164697 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44380708 57255 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL166610 57255 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
9329 3672 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 3672 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 3672 3 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
44277726 98640 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL280849 98640 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL413827 211330 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44177145 194045 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 194045 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44410321 140700 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL382988 140700 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993596 121538 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596452 121538 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
44324706 205525 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93038 205525 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
44348756 15377 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
CHEMBL122020 15377 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
10627355 119492 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 119492 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44297520 194399 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56069 194399 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294355 11123 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
49824390 11123 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178897 11123 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48454 11123 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
12225557 120651 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 120651 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
156500036 185852 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
CHEMBL4876457 185852 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
136046099 11035 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
49824391 11035 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178358 11035 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23181 11035 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
10456618 131700 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369692 131700 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10698161 5109 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106083 5109 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11363490 93609 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL24894 93609 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44359054 31595 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
CHEMBL140659 31595 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
10556941 98744 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
CHEMBL281530 98744 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
44333561 4587 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103221 4587 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
21753665 197986 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59310 197986 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10811257 101344 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 101344 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
16755279 174511 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL456875 174511 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL413827 211330 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44277726 98640 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL280849 98640 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
10350454 106236 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106236 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312951 102714 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL308363 102714 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
9831641 79272 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2115415 79272 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
10071124 98324 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL278351 98324 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10506376 55552 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162330 55552 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44304144 13310 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1192961 13310 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL544284 13310 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44288772 155053 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL40455 155053 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358416 27088 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL136735 27088 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44383969 128511 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 128511 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
10412224 86281 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL23184 86281 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
44324845 168716 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL441458 168716 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
104943 55084 34 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 55084 34 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10071124 98324 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL278351 98324 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
10004190 129552 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 129552 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10071124 98324 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL278351 98324 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
44294481 103020 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085125 103020 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799711 86990 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333632 86990 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
42639650 187602 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 187602 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44358552 118667 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
CHEMBL343150 118667 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
44270411 11863 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183074 11863 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278487 11863 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44359096 28903 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138146 28903 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
46227363 197974 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197974 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44212281 130081 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL368159 130081 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
44346420 14175 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
CHEMBL119990 14175 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
10393324 120283 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL355643 120283 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
56675185 66099 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817834 66099 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852026 66099 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
68870199 124261 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642171 124261 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44348605 112585 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
CHEMBL331346 112585 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
44288892 101022 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297970 101022 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44289168 168504 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL43977 168504 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL2112246 207479 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
71461705 79193 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2114963 79193 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
9914897 178470 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL47146 178470 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
21994362 29499 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
CHEMBL138666 29499 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
9914897 178470 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL47146 178470 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44212688 154495 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40164 154495 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44212684 162417 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417519 162417 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44287557 168120 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
CHEMBL436698 168120 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
15037919 119109 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 119109 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44307409 101774 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL303181 101774 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10458783 98151 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL277004 98151 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44312219 101898 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL303868 101898 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15639130 113003 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL332106 113003 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44346524 113009 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL332140 113009 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
10484232 193748 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55229 193748 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
22859118 167639 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL433539 167639 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
44346420 14175 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14175 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
58993475 121548 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596462 121548 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
46884434 7828 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 7828 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306252 101726 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
CHEMBL302892 101726 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
44306226 101759 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL303116 101759 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10005824 5811 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
CHEMBL107959 5811 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
9868622 6105 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108126 6105 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
9888665 121454 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121454 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44312256 202864 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL73097 202864 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44312888 96275 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL264384 96275 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
44319340 204187 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL84055 204187 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319250 106511 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315322 106511 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
158365 188127 4 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
CHEMBL504788 188127 4 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
44346524 113009 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL332140 113009 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
44328407 106810 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL317289 106810 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL406812 210864 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44344209 114038 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL333726 114038 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44375297 56483 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL164361 56483 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
19003143 202151 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68670 202151 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
10448006 202190 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68934 202190 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
44321047 204451 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL86378 204451 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
44346550 14504 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
CHEMBL120589 14504 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
44346476 113614 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
CHEMBL332843 113614 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
44287210 99890 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL289728 99890 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
54582278 60810 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765497 60810 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
16755278 189383 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL517102 189383 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL302668 209158 0 None - 0 Guinea pig 4.6 pIC50 = 4.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1 10.1021/jm00089a011
44297648 191970 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52139 191970 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44318406 169127 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL443799 169127 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
24782915 121552 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596466 121552 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44433795 88329 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL236304 88329 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
18709628 166244 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42845 166244 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
9873546 77668 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL209899 77668 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 113816 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 113816 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 113816 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44288926 101000 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297833 101000 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
104943 55084 34 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55084 34 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
25129133 188290 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188290 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44303794 100350 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293355 100350 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699790 124250 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642160 124250 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44381059 57514 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL167066 57514 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2112246 207479 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
CHEMBL2372444 208490 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
10478708 205829 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL94883 205829 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
21994346 29996 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139071 29996 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44312324 202968 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73896 202968 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15295988 60732 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176471 60732 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10477953 98465 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL279500 98465 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
19797451 36561 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145008 36561 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44307118 201312 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63257 201312 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24782656 121555 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596469 121555 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44338639 5634 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107831 5634 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338532 7534 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108822 7534 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322735 105484 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL313070 105484 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322728 204932 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89425 204932 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
9801487 205260 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 205260 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
25129133 188290 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188290 0 None -1122 5 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44306034 102241 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304897 102241 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL2369763 207926 8 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
10027061 14768 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120844 14768 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
44346175 12270 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
CHEMBL118565 12270 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
22293526 79282 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115452 79282 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
68932391 124255 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642165 124255 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
10459262 4798 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104435 4798 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44370954 167758 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL434272 167758 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
1122655 122569 22 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
CHEMBL361031 122569 22 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
21994363 118839 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL344370 118839 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL2112245 207478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44308931 202625 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71553 202625 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL2372517 208511 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44298065 194018 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL55691 194018 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL62581 214058 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/jm00089a011
10769264 9111 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110508 9111 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129135 172018 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172018 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44384678 61027 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
CHEMBL176860 61027 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
19797431 37187 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145514 37187 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44299814 167388 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
CHEMBL431725 167388 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
11409185 98951 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL282853 98951 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11329897 91452 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24136 91452 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10004190 129552 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 129552 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44287443 99795 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 99795 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
16755255 188532 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL510547 188532 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
11642147 87774 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347690 87774 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44288927 168202 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43744 168202 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44359109 31739 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL140768 31739 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
44297563 193277 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54435 193277 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44415393 79953 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL214435 79953 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
15755298 197029 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL58245 197029 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699789 124249 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642159 124249 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL2112245 207478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44294394 11133 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53838756 11133 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178980 11133 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52448 11133 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44297753 162117 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL417026 162117 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
10318912 97029 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL27026 97029 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
10249652 129198 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367423 129198 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
15295989 59353 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL172238 59353 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44324746 205557 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93251 205557 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
44334185 4485 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102525 4485 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44346664 16361 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL123764 16361 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
44334185 4485 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
CHEMBL102525 4485 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
44297466 101423 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300896 101423 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333727 108718 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL321710 108718 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
10627789 100099 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
CHEMBL29161 100099 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
24889458 8330 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 8330 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
10790827 119393 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
CHEMBL349273 119393 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
44306309 100512 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294342 100512 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10840510 164727 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423254 164727 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
54581251 60808 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765495 60808 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
56681832 66130 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817833 66130 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852229 66130 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
21994308 30215 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139256 30215 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10506124 100777 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL296228 100777 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44344995 95996 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL262301 95996 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44290659 101050 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL298247 101050 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL264341 208859 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
CHEMBL269584 209044 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
44337703 110185 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL326001 110185 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL2369630 207890 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44212285 123287 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
CHEMBL362394 123287 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
44276738 96729 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26831 96729 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
10045837 61033 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL176919 61033 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL2369605 207883 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
16755280 176214 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL460683 176214 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
54584234 60818 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765503 60818 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL2114443 207501 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
9851741 79768 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL213601 79768 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL2112242 207475 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10456592 5212 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL106609 5212 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
56657842 62897 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
CHEMBL1790897 62897 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
44359260 114973 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL335106 114973 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
10407571 167383 8 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL431690 167383 8 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10047989 92051 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
CHEMBL24314 92051 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
56671766 66096 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817828 66096 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852010 66096 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44303835 101283 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
CHEMBL299887 101283 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
21256636 29998 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139072 29998 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10047989 92051 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL24314 92051 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL216813 207586 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44321430 106490 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL315176 106490 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
10811257 101344 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 101344 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44277705 101484 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30139 101484 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44306217 201344 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL63471 201344 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44334111 109306 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL323317 109306 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL2372521 208514 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
24801797 86985 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333627 86985 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541470 86993 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333635 86993 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801101 87000 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL2333642 87000 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL306072 209221 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
67233125 125909 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651888 125909 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
71541575 86970 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333612 86970 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44277705 101484 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL30139 101484 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
10649948 6595 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108349 6595 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
18654560 111805 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329168 111805 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
44349003 17792 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126221 17792 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
10350454 106236 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106236 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44458353 99130 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 99130 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
10520658 98181 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL277260 98181 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
44337500 106692 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL316515 106692 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44458328 99041 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 99041 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44286798 166867 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL42972 166867 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10075002 4678 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103851 4678 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
10027219 99108 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 99108 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24799364 86978 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333620 86978 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9910432 132987 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
CHEMBL370816 132987 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
22724580 139625 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL380351 139625 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44358719 29620 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138764 29620 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358742 30733 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139854 30733 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10603097 56183 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163310 56183 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10674548 57127 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165510 57127 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44305544 201376 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63785 201376 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10457416 14702 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120781 14702 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
10457416 14702 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 14702 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11225834 98739 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL281491 98739 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10696382 121456 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL359214 121456 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL2115375 207512 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
56668399 66119 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817886 66119 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852139 66119 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10530699 119620 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351253 119620 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
9831309 134728 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL372587 134728 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
153996 112158 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL330366 112158 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL539021 112158 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
153996 112158 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL330366 112158 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL539021 112158 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44338583 5704 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
CHEMBL107875 5704 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
44338346 5779 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107941 5779 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338587 7343 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108667 7343 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44359083 29171 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL138390 29171 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
57398781 70594 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951619 70594 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
24888943 7850 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 7850 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941489 17534 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 17534 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
18709650 164684 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42295 164684 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
9888665 121454 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121454 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10721128 55978 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162977 55978 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10769745 57178 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165949 57178 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
132837 2198 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
9461 2198 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
CHEMBL22870 2198 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
44297434 193294 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54602 193294 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132837 2198 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2198 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2198 51 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
44273822 75138 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20430 75138 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL2372516 208510 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44289862 99874 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL289600 99874 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
21994258 118885 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL344646 118885 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328423 106874 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317761 106874 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL426363 211587 0 None 26 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 55084 34 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55084 34 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993517 121566 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596480 121566 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44433794 166881 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL429798 166881 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
9927183 193922 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
CHEMBL55591 193922 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
15214194 5031 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL105629 5031 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
10096063 107925 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL319874 107925 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
11757401 59616 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59616 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2089 2715 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 2715 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 2715 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 2715 21 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44415513 165204 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424709 165204 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44306327 12909 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL1189912 12909 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL539762 12909 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44306196 100254 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292715 100254 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306107 102349 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305547 102349 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
18709663 165538 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42597 165538 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44370340 119029 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL345866 119029 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
19797460 120486 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 120486 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305467 102326 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL305375 102326 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
71720664 86996 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333638 86996 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
24784193 121567 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596481 121567 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44456651 94993 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL257112 94993 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
73348949 90377 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 90377 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
44335354 4850 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
CHEMBL104708 4850 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
71458131 79259 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2115343 79259 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44276882 95765 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
CHEMBL26086 95765 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
71541687 86973 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333615 86973 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
57395687 68266 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917846 68266 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44433790 89000 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237100 89000 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
11114226 202835 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL72895 202835 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10075851 59692 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173564 59692 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 55084 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55084 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993461 121565 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596479 121565 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44370449 119379 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL349113 119379 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
46884470 7897 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 7897 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
19098237 36875 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 36875 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319086 13585 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194977 13585 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553617 13585 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
25129135 172018 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172018 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44334113 5179 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL106440 5179 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44326281 205449 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92524 205449 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44459032 90442 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23926 90442 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44318413 203960 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82220 203960 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
24783424 121559 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596473 121559 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10476776 108060 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL320231 108060 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288758 100629 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 100629 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
107686 3315 37 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3315 37 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3315 37 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44344231 113004 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL332111 113004 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44346159 14338 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
CHEMBL120190 14338 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
44177669 60917 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60917 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44319571 106544 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL315532 106544 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44415437 79552 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212697 79552 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
19797420 36614 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145051 36614 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10553958 100886 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL297068 100886 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
9915428 173051 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL45340 173051 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
44287895 100724 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 100724 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44304123 198883 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL59913 198883 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
10405990 206373 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL98011 206373 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
9915428 173051 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL45340 173051 2 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44287409 158491 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40969 158491 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287368 154670 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40262 154670 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287461 162132 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41705 162132 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44357469 161194 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
CHEMBL413904 161194 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
10367419 4323 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
CHEMBL101420 4323 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
11661655 105308 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126961 105308 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10480944 59563 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173013 59563 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
2089 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274341 81123 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21611 81123 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
56681830 66114 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817830 66114 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852124 66114 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10841047 57153 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165727 57153 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9918576 205596 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL93556 205596 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL2370873 208183 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC(=O)N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSC)C(N)=O 10.1016/S0960-894X(01)80229-8
44322406 164571 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL422773 164571 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322515 204979 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89818 204979 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10367419 4323 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101420 4323 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
10460069 165774 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL427295 165774 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44383815 59967 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
CHEMBL174365 59967 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
12736776 11037 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
53641783 11037 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178362 11037 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23360 11037 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
44459024 11042 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL1178380 11042 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL24818 11042 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
16755254 185582 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487259 185582 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
44386230 61019 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
CHEMBL176811 61019 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
10350528 106238 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106238 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44322511 106603 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL315937 106603 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346557 113008 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL332139 113008 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
15295990 131572 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369580 131572 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
54587143 60807 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765494 60807 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
11547090 87792 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347856 87792 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44306398 201845 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
CHEMBL66592 201845 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
10432488 4812 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL104513 4812 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
10026002 109183 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL322714 109183 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
44358442 29577 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138727 29577 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
107686 3315 37 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3315 37 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3315 37 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
104943 55084 34 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55084 34 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2089 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3795 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311311 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL217406 2715 21 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL263185 208806 4 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm070577s
44270482 11862 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183073 11862 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278455 11862 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
12736777 11036 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
54433543 11036 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178360 11036 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23287 11036 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
44348666 112980 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331978 112980 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44348801 112956 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331934 112956 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44337421 108028 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
CHEMBL320029 108028 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
44287388 155454 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40620 155454 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44297492 192880 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL52717 192880 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
131871 119010 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 119010 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44306416 100103 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL291634 100103 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370769 49732 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL156933 49732 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
19797413 36612 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145050 36612 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10552574 119461 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
CHEMBL349882 119461 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
44359259 24901 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
CHEMBL134737 24901 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
44275987 98872 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL282331 98872 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
9892852 83946 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 83946 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44297939 101193 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299312 101193 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
71699788 124248 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642158 124248 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
44289256 100052 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL291298 100052 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44270549 11020 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1178214 11020 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL15970 11020 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44312145 203000 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL74176 203000 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
10793140 57099 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
CHEMBL165308 57099 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
44297604 101152 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299016 101152 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44276732 99530 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL286747 99530 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24801102 87005 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333647 87005 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
46884468 7895 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 7895 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
44289441 100626 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL295107 100626 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10453364 5313 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107145 5313 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10433381 5494 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107689 5494 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10350528 106238 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106238 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44305511 201268 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63014 201268 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
9823811 59585 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL173110 59585 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44358814 30862 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139977 30862 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
44352062 18730 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 18730 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
131954513 161517 31 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 161517 31 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
21121353 100990 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 100990 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
54587142 60806 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765493 60806 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
44321519 204991 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL89897 204991 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321519 204991 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL89897 204991 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44307089 201315 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63278 201315 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL2112244 207477 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cn2ccc3ccccc32)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
76318226 105305 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126958 105305 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44294338 11929 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
54307293 11929 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183499 11929 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL300854 11929 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
11568372 204296 3 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 204296 3 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44380745 119779 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL352697 119779 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
10245452 100705 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL295680 100705 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
9888665 121454 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 121454 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10506928 119700 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 119700 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44297498 101519 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301630 101519 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10552836 4108 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL100141 4108 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
58993657 121540 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
CHEMBL3596454 121540 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
16755228 173122 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL453581 173122 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
19797456 34231 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142855 34231 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44319249 204342 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
CHEMBL85499 204342 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
44304176 201122 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62357 201122 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154442 14036 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
53703341 14036 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL1198573 14036 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL23147 14036 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
10071902 108901 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL321979 108901 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL2369630 207890 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44346480 114351 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334189 114351 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL2369767 207929 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
44299298 194565 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56176 194565 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
15037918 44585 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 44585 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
19797436 36591 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145030 36591 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797448 36996 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145360 36996 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44358500 31282 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
CHEMBL140360 31282 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
44287861 161178 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 161178 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
19797446 34307 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142919 34307 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
10793492 110801 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL326649 110801 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44358426 30654 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139753 30654 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10336036 111841 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
CHEMBL32940 111841 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
44359055 32101 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL141050 32101 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
10501444 101394 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 101394 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44287555 158242 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40944 158242 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
23294214 168583 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL440465 168583 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
76332769 105314 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126967 105314 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
10646925 30752 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL139868 30752 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44287895 100724 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 100724 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
16755230 172396 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL451773 172396 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
24801459 86989 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333631 86989 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
15755301 100588 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294814 100588 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44345010 14317 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL120126 14317 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10041813 96493 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL26623 96493 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10041813 96493 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL26623 96493 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
44297822 193344 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL54931 193344 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44321099 204493 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86659 204493 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15755334 96101 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
CHEMBL263013 96101 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
44177670 60918 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60918 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
71541471 86994 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333636 86994 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
71452815 79287 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2115528 79287 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
44328405 105704 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL313863 105704 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44338646 9051 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL110086 9051 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
10552836 4108 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL100141 4108 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576866 110990 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL327736 110990 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44294398 11124 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
54220048 11124 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL1178902 11124 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL48734 11124 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
16755206 186047 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL488045 186047 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
44303938 201449 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64166 201449 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154438 11041 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
53968534 11041 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178371 11041 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23682 11041 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
44288936 157611 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL40875 157611 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11409185 98951 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 98951 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
44287390 155220 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40587 155220 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44338557 9243 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111244 9243 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
132837 2198 51 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 2198 51 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 2198 51 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2198 51 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
11757401 59616 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 59616 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
56671913 66120 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817888 66120 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852140 66120 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
46884473 7692 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 7692 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10817203 57211 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
CHEMBL166240 57211 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
44305271 101761 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL303119 101761 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
44319323 13620 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1195230 13620 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL554092 13620 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL394671 210721 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
CHEMBL394671 210721 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44433788 88091 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235220 88091 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44328425 168893 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL442962 168893 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44233184 193090 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193090 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9871754 5322 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 5322 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
104943 55084 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL16192 55084 34 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44410162 76761 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207698 76761 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44294261 79208 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115010 79208 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
10086982 115679 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358422 115679 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
10072926 109185 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL322718 109185 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
9871754 5322 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 5322 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
134138503 153891 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3932836 153891 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3990081 153891 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
49863734 15145 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15145 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326362 205556 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
CHEMBL93243 205556 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
16755231 188395 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL508659 188395 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44306219 102243 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304901 102243 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44358703 115551 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL335624 115551 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9853506 12963 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1190281 12963 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL540553 12963 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9799676 194136 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55823 194136 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44456748 168603 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL440587 168603 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10071073 5264 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL106904 5264 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
44233410 193911 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 193911 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44433789 145589 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 145589 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
10792813 57197 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166144 57197 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44319224 106580 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315814 106580 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
10360490 88297 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL23617 88297 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL238168 208636 9 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
10007035 79100 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2114031 79100 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10460415 116026 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336261 116026 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10745307 164843 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL423824 164843 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL238168 208636 9 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
11547594 105323 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126975 105323 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
136043853 138373 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378340 138373 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
58993634 121573 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596487 121573 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
10438407 100174 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL292190 100174 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
57395686 71258 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917841 71258 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963411 71258 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
53249015 60815 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765500 60815 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
9939040 4926 5 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL105060 4926 5 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44358864 30117 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139176 30117 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44319306 106600 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315923 106600 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274183 82038 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21760 82038 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
56661423 66106 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817832 66106 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852069 66106 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
136043849 138158 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
CHEMBL377916 138158 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
44306108 102350 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305548 102350 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
22293578 186534 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL49175 186534 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44415424 140911 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384244 140911 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
11498370 100694 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL295615 100694 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
15295987 130817 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL368804 130817 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
15755316 201195 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
CHEMBL62711 201195 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
44299298 194565 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL56176 194565 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
16755256 172519 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452027 172519 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL2369599 207878 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
14986135 162837 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL419500 162837 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44287606 100032 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 100032 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10228092 76937 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20826 76937 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
58993510 121527 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596200 121527 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
54580277 60817 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765502 60817 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
9830535 205079 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90416 205079 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
9830535 205079 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL90416 205079 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
44294324 12241 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
54414362 12241 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1185473 12241 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL416468 12241 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
71583095 87777 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347693 87777 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71699791 124251 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642161 124251 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44337667 108357 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321021 108357 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10744740 109162 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL322508 109162 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
15154446 11033 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
53746881 11033 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178355 11033 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23073 11033 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
10318477 166745 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL429395 166745 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10318477 166745 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL429395 166745 36 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
107686 3315 37 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
3522 3315 37 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL131171 3315 37 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797466 34360 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142961 34360 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44297701 101208 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299388 101208 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11489240 94833 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL25639 94833 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44274520 82157 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21788 82157 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
44358861 118119 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL341681 118119 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
15755299 100408 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293726 100408 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10325464 119616 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 119616 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44458828 11040 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178368 11040 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23533 11040 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
44281769 109159 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL32248 109159 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
19098237 36875 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 36875 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10428330 169644 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
CHEMBL444552 169644 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
44297562 193357 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54940 193357 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10576866 110990 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL327736 110990 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881600 7012 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 7012 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44302017 197641 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59060 197641 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
71541370 86999 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333641 86999 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
10404051 85606 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23077 85606 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
10027661 59372 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
CHEMBL172308 59372 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
54585203 60816 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765501 60816 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
10053205 116072 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 116072 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
46884469 7896 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 7896 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL2369630 207890 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44344195 162796 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 162796 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL307433 209224 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44328357 111036 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL327943 111036 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44287556 99736 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL288382 99736 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
11641636 105324 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126976 105324 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
24801457 87001 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333643 87001 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44415472 139058 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379744 139058 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44433781 89483 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL237992 89483 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
44303900 162342 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL417390 162342 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
15154449 11860 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
54080603 11860 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1183064 11860 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL278135 11860 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
44297724 101440 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301008 101440 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44286772 167265 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43085 167265 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
56668295 66125 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817836 66125 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852171 66125 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
10393390 97812 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL27463 97812 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10317867 4780 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104345 4780 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44287511 144193 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL39089 144193 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24785190 121543 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596457 121543 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
52941506 17570 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 17570 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
76314659 105319 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126971 105319 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44287819 100913 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL297244 100913 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
10386984 5326 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107220 5326 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10625208 55556 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
CHEMBL162332 55556 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
76332768 105313 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126966 105313 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
44288896 168410 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 168410 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL2372519 208513 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O 10.1021/jm00037a009
44277452 100600 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL29487 100600 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
44348667 113816 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 113816 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 113816 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44212283 59531 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL172915 59531 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
71541371 87004 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333646 87004 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10253192 4839 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104654 4839 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44312028 102366 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL305609 102366 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10627355 119492 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 119492 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44328395 107013 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL318629 107013 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
19003169 102302 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL305274 102302 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44321047 204451 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
CHEMBL86378 204451 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
44326328 205366 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92032 205366 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44346420 14175 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14175 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
107686 3315 37 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 3315 37 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 3315 37 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
18782568 205541 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL93184 205541 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
24784955 121553 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596467 121553 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL311405 209343 15 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44305865 100204 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL292346 100204 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL2092883 207448 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10258592 98737 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL281481 98737 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44368172 120988 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL358409 120988 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
10097954 131586 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL369601 131586 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44287609 99884 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 99884 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
24783681 121554 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596468 121554 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415458 79924 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL214317 79924 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415539 138437 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378537 138437 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44305864 201794 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
CHEMBL66193 201794 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
44358519 30527 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139569 30527 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44338584 8058 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109183 8058 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
22353151 9028 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109937 9028 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338618 108825 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL321892 108825 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44346558 15200 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121459 15200 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
24889114 7654 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 7654 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
11743365 106891 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL317870 106891 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
44178113 60920 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 60920 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44274530 98463 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279488 98463 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
24782655 121556 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596470 121556 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415486 80487 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL215315 80487 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
44358469 30913 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
CHEMBL140023 30913 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
10623791 30674 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139784 30674 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541572 86965 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333608 86965 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541573 86966 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333609 86966 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
22293463 100833 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296629 100833 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415412 78301 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211257 78301 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10553136 164761 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423464 164761 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
46884516 7729 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 7729 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306036 13641 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL1195366 13641 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL554413 13641 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306318 202079 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL68225 202079 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44358545 27217 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136832 27217 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9976640 194943 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
CHEMBL56427 194943 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
9976640 194943 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56427 194943 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274170 76704 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20736 76704 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
44274199 98290 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL278088 98290 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
10392469 193176 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 193176 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44370928 47477 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL154803 47477 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
10603392 57137 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165566 57137 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274118 98484 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL279674 98484 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
57397019 71175 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951617 71175 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1962935 71175 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
46884519 7994 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 7994 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
24752434 9030 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 9030 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10743826 118068 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341656 118068 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
44415484 168361 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 168361 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44326361 110992 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL327765 110992 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44326361 110992 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL327765 110992 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
9874168 203981 3 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL82386 203981 3 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
23025461 66104 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852063 66104 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL3216952 66104 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
9805809 102600 6 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 102600 6 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
11844212 98183 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL277279 98183 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 113816 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 113816 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 113816 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44338652 108110 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL320544 108110 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44322736 205263 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL91436 205263 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44233185 193144 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193144 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL5083565 213089 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44458789 141269 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
CHEMBL386306 141269 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
44458351 98918 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 98918 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL410808 211086 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
15755314 101715 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
CHEMBL302843 101715 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
44458789 141269 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
CHEMBL386306 141269 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
18655106 198775 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
CHEMBL59854 198775 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
44287443 99795 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 99795 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10697072 55509 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162288 55509 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
22901331 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
22901331 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
54435601 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
59922977 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL1183068 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL278294 11861 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
44318310 203935 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL81986 203935 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
44333682 4539 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102887 4539 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
11490127 91638 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24194 91638 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
12225557 120651 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 120651 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
24801792 87002 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333644 87002 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
54582296 60811 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765498 60811 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
10473960 85841 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
CHEMBL23129 85841 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
44177570 60916 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60916 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
68932301 124259 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642169 124259 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44288795 167698 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43394 167698 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10917690 205861 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
CHEMBL95051 205861 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
44286718 167155 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43027 167155 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44383969 128511 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 128511 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
44383969 128511 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 128511 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
54585202 60812 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765499 60812 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
54585205 60821 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765506 60821 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
46884432 7825 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 7825 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44297602 193562 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL55098 193562 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL2114442 207500 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
24783683 121551 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596465 121551 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
24889111 7827 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 7827 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10370593 6171 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL108164 6171 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44288976 162668 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL418438 162668 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 106254 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106254 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312887 102451 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL306267 102451 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
24782658 121546 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596460 121546 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
22851562 165889 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL42778 165889 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44297451 100180 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292211 100180 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
16755232 173006 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL453314 173006 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
21308488 101020 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL297957 101020 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL2369601 207880 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm960281e
10043484 89021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
CHEMBL23715 89021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
44334006 107117 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL318989 107117 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44297513 101121 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL298772 101121 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
10499624 116121 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL336931 116121 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44308930 202614 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71498 202614 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44308930 202614 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL71498 202614 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44299916 194119 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55796 194119 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
9869033 99945 3 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 99945 3 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
56675290 66101 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1817884 66101 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1852032 66101 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
16755257 172804 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452794 172804 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
44324532 205106 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90547 205106 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
15755319 100201 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL292320 100201 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10410206 79159 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL2114308 79159 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
10410322 98931 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
CHEMBL282728 98931 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
10043484 89021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
CHEMBL23715 89021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
10043484 89021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
CHEMBL23715 89021 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
44297931 192102 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL52198 192102 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44287191 157127 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40817 157127 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44275987 98872 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL282331 98872 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
19797477 38413 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL146552 38413 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
9984184 202933 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73618 202933 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44383681 165705 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL426939 165705 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
10411026 61012 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176772 61012 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
44319341 204164 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83885 204164 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44297493 162587 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL417914 162587 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
10620143 98792 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL281828 98792 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
54582297 60819 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765504 60819 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
71583092 87783 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
CHEMBL2347703 87783 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
44324527 106043 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
CHEMBL314084 106043 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
10620143 98792 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL281828 98792 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44274242 98681 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL281149 98681 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
10553958 100886 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL297068 100886 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL5076397 212654 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of tachykinin NK1 receptor (unknown origin)Inhibition of tachykinin NK1 receptor (unknown origin)
ChEMBL None None None O[C@H]1COC[C@H]1N1CC[C@@H](c2cc3nc(Nc4cnn([C@@H]5CC5(F)F)c4Cl)ncc3cc2Cl)[C@H](F)C1 10.1021/acs.jmedchem.1c01968
10553958 100886 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL297068 100886 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44297469 101298 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300005 101298 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44328545 205908 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95270 205908 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL1196922 206844 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
CHEMBL558620 206844 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10692651 100607 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 100607 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44294261 79283 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115454 79283 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2112241 207474 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)O)NC2=O)cc1 10.1021/jm960281e
44375315 56198 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 56198 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
10530317 5142 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL106239 5142 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44286754 162582 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL417881 162582 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
104974 3406 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
2111 3406 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
3481 3406 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL308148 3406 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
DB06660 3406 27 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL2369604 207882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44324531 205018 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90035 205018 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
44433803 146249 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 146249 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
44289934 100776 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL296216 100776 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44358672 118840 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
CHEMBL344378 118840 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
21121353 100990 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 100990 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
71452678 78152 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2112211 78152 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
9868530 76964 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL20837 76964 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24800398 86968 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333610 86968 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
56678486 66121 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817837 66121 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852157 66121 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
9874168 203981 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL82386 203981 3 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
44408144 74902 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL203700 74902 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
44415411 138243 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378076 138243 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
2755911 75073 48 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75073 48 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44274104 80133 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21489 80133 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
18669089 98469 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279523 98469 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24799187 86984 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333626 86984 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
22293526 79206 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115008 79206 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24785443 121541 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596455 121541 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
44338586 6792 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL108422 6792 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
71541577 86972 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333614 86972 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
46884518 7881 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 7881 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306436 100520 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294370 100520 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335360 4781 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL104348 4781 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
44358427 30783 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139903 30783 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44325096 111031 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327928 111031 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
58993609 121550 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596464 121550 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
40727876 115680 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358423 115680 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
44297642 193769 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55240 193769 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
53379507 66105 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817829 66105 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852067 66105 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10390130 98771 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281717 98771 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
11619202 87781 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347697 87781 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
107686 3315 37 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3315 37 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3315 37 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44299943 193879 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55476 193879 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10602065 35155 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143775 35155 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44358670 29743 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL138853 29743 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44297463 162557 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417731 162557 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10327540 162941 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL420221 162941 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
44289219 161741 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL416436 161741 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
118722857 115678 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358421 115678 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44333606 5065 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105800 5065 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
10342797 90444 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
CHEMBL23927 90444 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
24800925 87003 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333645 87003 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL405795 210824 6 None - 0 Guinea pig 6.2 pIC50 = 6.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
10458786 5336 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107283 5336 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288934 154540 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL40189 154540 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10087358 60006 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
CHEMBL174465 60006 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
21308490 101164 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299089 101164 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
44346675 113743 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
CHEMBL333039 113743 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
44337704 167560 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432979 167560 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44297859 101234 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
CHEMBL299528 101234 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
21994329 28693 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137972 28693 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL2112246 207479 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
11724403 167969 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 167969 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10389807 96149 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL26336 96149 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL411230 211117 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44433785 146364 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392566 146364 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
68870858 124258 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642168 124258 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
18391053 166015 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42800 166015 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797458 33988 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142638 33988 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
19797415 37992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
CHEMBL146223 37992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
44287481 162420 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417522 162420 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10650263 25867 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 25867 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44345147 110798 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL326613 110798 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297649 188116 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL50455 188116 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10052114 165519 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL425848 165519 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10837320 35204 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143813 35204 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL265573 208899 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44384901 169326 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
CHEMBL444086 169326 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
44384986 129239 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
CHEMBL367528 129239 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
44411637 138737 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
CHEMBL379097 138737 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
44344195 162796 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 162796 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
10055415 106261 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106261 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL418757 211481 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
58993550 121539 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596453 121539 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44384677 130923 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
CHEMBL369174 130923 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
44413144 138676 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
CHEMBL378784 138676 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
54582277 60804 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765491 60804 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
28558057 162487 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41762 162487 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24801627 86974 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333616 86974 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10695397 189004 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL51477 189004 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
46884517 7993 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 7993 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10026200 4764 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104277 4764 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44385575 59469 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL172676 59469 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
71583203 87779 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347695 87779 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
10473960 85841 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
CHEMBL23129 85841 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
10473960 85841 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23129 85841 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44415423 138711 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378984 138711 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71699787 124247 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642157 124247 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797468 37508 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145801 37508 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19003156 66790 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
CHEMBL187554 66790 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
10473960 85841 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
CHEMBL23129 85841 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
15639109 163471 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL420876 163471 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44321046 204489 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86643 204489 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321046 204489 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86643 204489 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44321493 204506 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
CHEMBL86746 204506 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
10451098 11686 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
CHEMBL118194 11686 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
44307137 101628 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL302315 101628 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24783930 121547 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596461 121547 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
10030004 110844 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL326889 110844 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
15391369 102342 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL305509 102342 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44328389 106740 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL316842 106740 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
4189 205185 91 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205185 91 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205185 91 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10405461 60005 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
CHEMBL174464 60005 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
2090 2716 20 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 2716 20 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 2716 20 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44384987 61010 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL176769 61010 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44289169 101005 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 101005 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
54585204 60820 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765505 60820 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
10031310 4627 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103510 4627 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
10339539 109267 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 109267 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
44276788 96036 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
CHEMBL26251 96036 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
44319329 204244 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL84588 204244 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44306045 100187 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292256 100187 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
9871754 5322 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 5322 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
21994328 30978 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140086 30978 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
24784190 121558 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596472 121558 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
9855000 20406 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 20406 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44328400 107612 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL319559 107612 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44415435 79716 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213359 79716 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415469 166865 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL429715 166865 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
11546759 87791 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347855 87791 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
21994352 118763 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
CHEMBL343797 118763 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
10626865 57204 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166178 57204 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44328424 106811 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317297 106811 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227360 200886 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200886 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
10839068 118206 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL341745 118206 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
24993312 178763 10 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 178763 10 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
10436850 79221 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2115107 79221 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
11546190 105307 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126960 105307 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
19098236 33796 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL142477 33796 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319082 167453 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL432183 167453 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
18669085 82949 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21939 82949 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44306693 101865 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
CHEMBL303750 101865 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
44358476 30134 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL139190 30134 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
44297629 189906 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51794 189906 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
46884515 7728 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 7728 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44456866 157415 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408484 157415 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24993955 183713 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 183713 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL276294 209073 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O 10.1021/jm00037a009
44415447 141008 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384796 141008 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44338640 167515 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL432627 167515 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44321099 204493 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86659 204493 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44368159 47915 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL155218 47915 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44346420 14175 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 14175 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44288758 100629 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 100629 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
24785191 121544 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596458 121544 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
44294423 11919 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53817703 11919 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183414 11919 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295686 11919 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15037919 119109 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 119109 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
71541376 86988 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333630 86988 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785445 121537 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596451 121537 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
10668476 98976 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL282996 98976 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
9957036 163595 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL42103 163595 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10668476 98976 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL282996 98976 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44380709 119875 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL353416 119875 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44297359 191739 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL52070 191739 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
44345156 113595 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL332759 113595 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10674743 109716 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL323762 109716 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
100951644 169056 11 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
CHEMBL4437106 169056 11 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
24889283 8331 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 8331 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
44289218 163146 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42050 163146 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44233184 193090 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193090 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
15037920 45458 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 45458 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44363017 37056 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
CHEMBL145407 37056 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
44358982 30435 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139464 30435 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
42639649 170168 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 170168 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44370352 51204 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL158255 51204 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44212282 60943 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL176682 60943 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
19960248 169506 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL444339 169506 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
10452352 127990 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
CHEMBL366753 127990 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
76336391 105312 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126965 105312 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
71541372 87006 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333648 87006 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
11634999 87775 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347691 87775 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
131871 119010 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 119010 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44359010 29770 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138883 29770 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
23294208 96687 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL26790 96687 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44299310 96274 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL264376 96274 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL436706 211928 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(N)=O 10.1016/S0960-894X(01)80229-8
44346497 14359 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL120286 14359 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10407632 101341 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30029 101341 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10736544 102269 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL305094 102269 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
10520658 98181 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 98181 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10025594 90445 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL23928 90445 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
24799365 86977 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333619 86977 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9852376 98632 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL280789 98632 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44385121 60825 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
CHEMBL176557 60825 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
44299753 193959 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55635 193959 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44287861 161178 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 161178 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL415600 211436 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
56661421 66100 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817831 66100 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852028 66100 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
44312000 202963 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73839 202963 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
14999557 102139 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304246 102139 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
68870105 124254 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642164 124254 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
16755281 176215 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
CHEMBL460684 176215 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
44297698 193310 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54717 193310 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
68932311 124260 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642170 124260 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44322724 204564 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87066 204564 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
24800577 86986 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333628 86986 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
15755302 101836 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303543 101836 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44458869 11866 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL1183106 11866 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL280339 11866 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
44375286 119592 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL351059 119592 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
9827668 111767 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL329105 111767 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11647974 105318 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126970 105318 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
9938657 59891 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 59891 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
9827668 111767 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL329105 111767 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44458598 98379 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL278849 98379 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
107686 3315 37 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 3315 37 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 3315 37 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44274331 82034 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
CHEMBL21759 82034 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
44433799 88226 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 88226 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44306000 100403 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL293675 100403 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370925 119095 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL346485 119095 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
132837 2198 51 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 2198 51 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 2198 51 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
58993629 121576 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596490 121576 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
24888772 7919 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 7919 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44319307 106052 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL314119 106052 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415399 79629 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL212978 79629 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415449 79840 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213908 79840 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44290030 172956 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL45316 172956 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
19797439 36640 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 36640 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
10577745 56834 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164563 56834 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
24782913 121563 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596477 121563 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
57402686 71246 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963297 71246 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3217199 71246 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10053175 4785 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104370 4785 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44319223 106608 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
CHEMBL315982 106608 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
10202046 120535 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 120535 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
46884471 7652 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 7652 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44352062 18730 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 18730 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44319355 105030 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL312173 105030 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
71541473 86964 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333607 86964 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
107686 3315 37 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 3315 37 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 3315 37 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44319308 105884 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313931 105884 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274181 77842 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21062 77842 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
44358475 30132 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139189 30132 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10063954 98266 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL277918 98266 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44297484 194319 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56003 194319 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
18986937 167583 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL433107 167583 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
68930433 124256 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642166 124256 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797417 37069 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145414 37069 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10099318 56876 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164912 56876 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
14986135 162837 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 162837 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44337620 109238 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL322976 109238 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9979913 107972 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL319932 107972 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
104974 3406 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
2111 3406 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
3481 3406 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL308148 3406 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
DB06660 3406 27 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL334721 209643 1 None - 3 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/S0960-894X(96)00570-7
44358520 30142 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139198 30142 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44346693 15214 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL121480 15214 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44366601 42166 9 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
CHEMBL149905 42166 9 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
104943 55084 34 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 55084 34 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
44346200 14281 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL120038 14281 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
44299876 162615 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL418114 162615 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44274392 77722 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21018 77722 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
22293476 79280 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115450 79280 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44337569 9115 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL110558 9115 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10520658 98181 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 98181 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL2369630 207890 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
9851211 5113 28 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL106092 5113 28 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44287606 100032 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 100032 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10344874 119632 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 119632 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
10907460 9720 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 9720 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
10548166 34859 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
CHEMBL143377 34859 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
68928720 124264 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642174 124264 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
10454303 5396 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL107619 5396 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
44458353 99130 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 99130 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
44307090 100230 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL292496 100230 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
21955298 79281 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115451 79281 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2369607 207885 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10840161 167695 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL433906 167695 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9832198 106260 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106260 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44294408 11131 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178974 11131 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52114 11131 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44294305 11920 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972643 11920 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183417 11920 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295781 11920 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
21994241 29539 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138695 29539 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
71458099 79166 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2114398 79166 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44348676 17752 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126009 17752 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
19797445 118920 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL344970 118920 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44383265 119996 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
CHEMBL354542 119996 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
10408564 5891 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108010 5891 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10474902 88243 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23597 88243 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299830 194992 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL56458 194992 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44274326 81126 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21612 81126 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
58993640 121535 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596449 121535 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
2090 2716 20 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311312 2716 20 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL437797 2716 20 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
44297523 100213 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292404 100213 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44288770 159253 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
CHEMBL41057 159253 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
10408912 95949 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL26193 95949 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
44274534 98489 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279726 98489 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
46884431 7957 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 7957 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
54581461 60919 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60919 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
44276792 98661 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL281019 98661 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44297685 100596 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL294843 100596 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44334072 5011 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105560 5011 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
11295303 94606 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25521 94606 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
44305557 201116 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL62341 201116 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
44287803 99734 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 99734 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44410194 76515 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL206983 76515 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
16755253 185597 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487276 185597 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
118722858 115681 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358424 115681 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
44306757 100472 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
CHEMBL294114 100472 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
44306092 201724 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL65703 201724 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324793 205264 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL91438 205264 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44324775 205573 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93401 205573 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44289197 100672 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL295425 100672 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
104943 55084 34 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 55084 34 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797460 120486 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 120486 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305557 201116 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL62341 201116 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10063954 98266 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL277918 98266 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
71541472 86963 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333606 86963 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44346536 16114 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
CHEMBL122580 16114 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
44306106 102321 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305368 102321 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10531588 119836 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
CHEMBL353116 119836 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
44346536 16114 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL122580 16114 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
19049319 162572 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL417784 162572 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
19049319 162572 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417784 162572 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797439 36640 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 36640 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
19049319 162572 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
CHEMBL417784 162572 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
56658036 66115 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817885 66115 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852128 66115 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
23653789 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
23653789 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3517 19 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
10698085 19192 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL129354 19192 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
24888942 7849 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 7849 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44299463 194859 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56372 194859 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44290080 193178 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL539937 193178 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44319356 103879 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL310173 103879 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415529 139484 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL380017 139484 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24993313 186438 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 186438 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
10499846 30993 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
CHEMBL140101 30993 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
130847 198886 13 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59915 198886 13 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
43815 186327 58 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL1708 186327 58 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL490 186327 58 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL2112245 207478 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
54581252 60809 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765496 60809 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11248796 161088 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL413027 161088 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44289102 167933 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL435367 167933 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
76311027 105316 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126969 105316 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
18986942 202208 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL69051 202208 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
44299898 162567 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417766 162567 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797414 36933 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145308 36933 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44324681 111960 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329840 111960 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
44281769 109159 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
CHEMBL32248 109159 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
44345938 11883 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
CHEMBL118328 11883 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
10339539 109267 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 109267 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL2092730 207447 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
45271306 193989 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193989 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
46227362 200888 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200888 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274254 79781 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21366 79781 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
11661466 36670 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145103 36670 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL2112246 207479 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44274444 82152 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21787 82152 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
11801586 5377 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 5377 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL2112245 207478 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
CHEMBL2369766 207928 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
56671764 66094 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817821 66094 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852008 66094 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
56671762 66112 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817820 66112 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852121 66112 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
23025476 66127 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1817817 66127 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1852184 66127 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
2090 2716 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
5311312 2716 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL437797 2716 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44358847 29941 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
CHEMBL139017 29941 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
54586136 60805 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765492 60805 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
2090 2716 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
5311312 2716 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
CHEMBL437797 2716 20 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
44375315 56198 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 56198 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44318671 105630 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL313432 105630 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
15037918 44585 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 44585 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
5757 3911 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 3911 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 3911 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 3911 10 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10907397 43621 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151177 43621 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366788 43889 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
CHEMBL151585 43889 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
22901331 11861 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11861 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11861 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11861 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11861 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
18964186 202591 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
CHEMBL71397 202591 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
2102 1162 17 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1162 17 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1162 17 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
21836542 42042 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL149794 42042 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11005795 41926 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
CHEMBL149690 41926 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
21699577 43087 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150709 43087 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10918128 119333 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL348653 119333 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10973497 42976 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150619 42976 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
23224631 43652 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151231 43652 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11071954 164775 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL423584 164775 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
22901331 11861 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11861 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11861 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11861 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11861 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10864234 43718 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151317 43718 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10929285 66361 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL185572 66361 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
21836537 41108 5 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL148998 41108 5 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366712 43242 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL150842 43242 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11028028 43409 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150997 43409 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11060266 43879 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL151570 43879 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
22901331 11861 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11861 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11861 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11861 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11861 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10984417 43518 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151088 43518 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44366743 43700 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL151289 43700 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
11813113 42875 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150537 42875 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11827396 42946 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150585 42946 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836550 118965 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345309 118965 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11071343 120990 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL358418 120990 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366283 39287 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147301 39287 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103819 118961 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL345288 118961 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836558 120759 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357946 120759 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11123982 43919 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
CHEMBL151621 43919 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
44300138 100417 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293804 100417 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
21836503 41693 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL149469 41693 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
44300056 100356 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293374 100356 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555235 100356 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300032 197406 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58873 197406 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
52937467 62179 0 None -9 4 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 62179 0 None -9 4 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
21836538 39235 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147241 39235 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
10864203 43436 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151026 43436 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44300037 191325 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL52004 191325 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
104943 55084 34 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55084 34 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
71452185 83108 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83108 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300106 196592 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL57584 196592 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11135103 121047 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
CHEMBL358600 121047 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
11113999 43604 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151155 43604 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11763019 119172 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
CHEMBL347284 119172 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
44241710 83104 0 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83104 0 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300497 100278 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL292816 100278 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
22901331 11861 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11861 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11861 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11861 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11861 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
11071001 42710 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
CHEMBL150381 42710 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
44366988 43742 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151356 43742 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366559 119013 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345733 119013 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366577 120585 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357357 120585 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
52937271 62177 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 62177 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 117641 0 None -389 3 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 117641 0 None -389 3 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
6604943 101257 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL299701 101257 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555236 101257 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300034 196818 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
CHEMBL57778 196818 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
71457524 83106 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83106 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10864032 43439 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151028 43439 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836496 120366 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL355973 120366 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
104943 55084 34 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55084 34 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
118730934 117642 0 None -363 3 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 117642 0 None -363 3 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44300055 100523 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL294452 100523 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11813288 43013 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
CHEMBL150644 43013 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
44366742 43699 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151288 43699 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103197 77989 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL2111193 77989 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
132927 4009 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
138398059 4009 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
677 4009 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL294453 4009 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL551291 4009 3 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
9847362 121162 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL358694 121162 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
135413536 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 444 80 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
44300139 197355 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58598 197355 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
118730932 117640 0 None -2951 3 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 117640 0 None -2951 3 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
25129133 188290 0 None 102 5 Human 11.2 pKi = 11.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188290 0 None 102 5 Human 11.2 pKi = 11.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
10288987 18015 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
CHEMBL1270066 18015 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
122187724 122537 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 122537 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10216430 79480 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212428 79480 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
5752 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
6918331 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
CHEMBL522302 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
DB12436 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
5752 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
6918331 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL522302 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
DB12436 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL3609617 210074 0 None 501 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10714695 41776 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL149557 41776 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 77824 13 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 77824 13 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419537 208683 0 None 32 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44264764 13061 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1191008 13061 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL542044 13061 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
22880695 13460 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1194085 13460 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL545594 13460 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
127944 120399 2 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL356062 120399 2 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL555572 120399 2 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL3608939 210071 0 None 1 3 Rat 10.4 pKi = 10.4 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL261390 208763 0 None 34 3 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44177770 122473 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 122473 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10500669 38825 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146885 38825 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10809458 118869 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL344536 118869 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
127944 120399 2 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356062 120399 2 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL555572 120399 2 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5752 3930 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
6918331 3930 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
CHEMBL522302 3930 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
DB12436 3930 20 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
44264847 12698 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1188354 12698 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL536103 12698 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44264766 13429 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193883 13429 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL545360 13429 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
45271306 193989 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193989 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
11793012 120521 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356786 120521 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10499614 121451 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359188 121451 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 77824 13 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 77824 13 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
22880684 13369 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193478 13369 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544891 13369 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
24969015 92531 3 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441373 92531 3 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419538 208684 0 None 75 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
44177570 60916 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60916 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44233185 193144 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193144 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
135413536 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
230 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
3490 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
6918365 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
CHEMBL1471 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
DB00673 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
10641076 167842 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL434884 167842 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10152974 57547 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672044 57547 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
15463537 13869 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1197007 13869 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL558990 13869 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
51002938 57550 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672047 57550 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL389652 210673 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 210673 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419542 208688 0 None 6 3 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419541 208687 0 None 3 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419543 208689 0 None 16 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
9871118 145587 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3919618 145587 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2109 4060 3 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9852253 4060 3 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
CHEMBL129683 4060 3 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
10173872 138730 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379072 138730 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46227362 200888 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200888 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
51002993 57556 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672053 57556 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL3609616 210073 0 None 1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL2419539 208685 0 None 25 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
2109 4060 3 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
9852253 4060 3 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
CHEMBL129683 4060 3 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
10546738 165045 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL424301 165045 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
23725089 789 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 789 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 789 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 789 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 789 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 789 8 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
72203985 92529 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441371 92529 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL1651026 207073 19 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
9961315 117408 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
CHEMBL340326 117408 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
51003118 57554 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672051 57554 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL3609616 210073 0 None -1 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10288987 18015 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270066 18015 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10495476 39656 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147776 39656 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10643148 121017 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL358575 121017 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10784942 121463 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359255 121463 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
51002996 57560 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672058 57560 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
2102 1162 17 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1162 17 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1162 17 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
105083 25232 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
CHEMBL135022 25232 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
2102 1162 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 1162 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 1162 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
2102 1162 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 1162 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 1162 17 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
9809876 19187 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL129321 19187 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
51003056 57551 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672048 57551 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
49863732 15143 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15143 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
10217362 18095 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270565 18095 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10547681 120552 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL357029 120552 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
21041073 138307 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 138307 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
51003119 57555 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672052 57555 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
53320128 57558 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672056 57558 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
10290124 92530 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441372 92530 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
10289148 146567 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3927453 146567 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3609618 210075 0 None 16 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44560810 172694 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL452534 172694 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
9958115 172917 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453054 172917 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560811 188396 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL508661 188396 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
11327981 181686 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL478392 181686 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL229280 207703 0 None 23 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
51003053 57561 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672059 57561 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
44177669 60917 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60917 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10217361 18094 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270564 18094 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
5757 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
9832383 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
CHEMBL522987 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
DB11949 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
5757 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 3911 10 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10289302 18035 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270175 18035 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
9872808 57548 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672045 57548 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
46227363 197974 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197974 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
2102 1162 17 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5311057 1162 17 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL441225 1162 17 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5757 3911 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
9832383 3911 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
CHEMBL522987 3911 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
DB11949 3911 10 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
2102 1162 17 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
5311057 1162 17 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL441225 1162 17 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
10598278 13796 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196442 13796 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556981 13796 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
52943331 18050 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270271 18050 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52947014 18107 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270664 18107 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
2102 1162 17 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 1162 17 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 1162 17 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
9852904 116523 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
CHEMBL339051 116523 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
51002992 57553 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672050 57553 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
122187724 122537 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 122537 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52940937 18078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270465 18078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10152358 18034 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270174 18034 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL389652 210673 0 None 2 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL389652 210673 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419541 208687 0 None -3 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 210673 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
153996 112158 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL330366 112158 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL539021 112158 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
9831546 203454 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78284 203454 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2397481 208661 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
11712457 18151 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270970 18151 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL2397481 208661 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2018.06.009
10128086 79401 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212112 79401 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128366 79839 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213906 79839 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128322 172393 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL451765 172393 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10311126 172618 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452270 172618 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44560775 172692 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452532 172692 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
104943 55084 34 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55084 34 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
44241723 83105 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 83105 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10603544 110062 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 110062 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
51002995 57559 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672057 57559 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
52945787 18077 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270464 18077 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
23725089 789 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 789 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 789 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 789 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 789 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 789 8 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
122187205 122474 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 122474 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52942011 18137 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270868 18137 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52943450 18016 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270067 18016 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
52946917 18122 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270766 18122 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10174642 146003 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3922759 146003 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2102 1162 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
5311057 1162 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
CHEMBL441225 1162 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
2102 1162 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
5311057 1162 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
CHEMBL441225 1162 17 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
44408025 75547 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 75547 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
10363623 84441 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL22360 84441 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
15463538 13779 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196327 13779 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556562 13779 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
102023780 120222 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10417302 120222 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380072 120222 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355041 120222 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9852630 203135 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75598 203135 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
22960738 74919 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
CHEMBL203716 74919 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
10164354 165437 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL425406 165437 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
18403344 140370 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL382242 140370 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
52942012 18138 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270869 18138 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10173872 138731 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379073 138731 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
10128086 138981 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL379520 138981 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
44560832 176229 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL460890 176229 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560834 189394 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL517121 189394 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
104943 55084 34 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 55084 34 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
11490769 83109 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 83109 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
9874473 41549 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41549 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44307758 201853 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 201853 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10311483 144328 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3909899 144328 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL2370435 208094 0 None 48 2 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
44140365 186446 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490926 186446 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10173890 77845 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210641 77845 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
51003178 57557 3 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672055 57557 3 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
9873032 75017 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203867 75017 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL3609615 210072 0 None -2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
2102 1162 17 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 1162 17 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 1162 17 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
44380081 57786 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167546 57786 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9810434 103891 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL310273 103891 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44407938 139903 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL380931 139903 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
52937467 62179 0 None -9 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 62179 0 None -9 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937467 62179 0 None -9 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 62179 0 None -9 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
52937467 62179 0 None -9 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 62179 0 None -9 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
135416054 79799 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213735 79799 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 79895 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214194 79895 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
44560809 172918 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453055 172918 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560833 176268 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL461299 176268 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44241723 83105 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 83105 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10698493 109278 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL323224 109278 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
10522676 118643 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL342966 118643 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10761962 118708 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343404 118708 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
24969353 197458 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
CHEMBL589371 197458 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
46224928 197711 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 197711 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
46889695 6836 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084436 6836 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
104974 3406 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
2111 3406 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
3481 3406 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
CHEMBL308148 3406 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
DB06660 3406 27 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
46227361 200887 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200887 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
11261795 197015 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL492117 197015 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL581391 197015 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
52943348 18108 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270665 18108 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10462 1977 7 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
9808518 1977 7 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
CHEMBL206488 1977 7 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
122187205 122474 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 122474 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10311496 18062 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270370 18062 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380448 119761 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352588 119761 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315483 96138 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL263243 96138 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
101195489 155068 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9875056 155068 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL404599 155068 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9853636 203729 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL80355 203729 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10296442 75140 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204306 75140 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
24768355 168318 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 168318 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10296442 75140 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL204306 75140 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560773 172390 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451763 172390 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
10194796 191249 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL519914 191249 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL439019 212060 0 None 3 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
52940879 18129 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270786 18129 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
44307773 101877 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 101877 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 201833 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 201833 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889696 6837 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084437 6837 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
24768355 168318 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 168318 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71458106 79174 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
CHEMBL2114439 79174 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
51003117 57552 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672049 57552 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
10311306 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5027 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5749 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
CHEMBL3707331 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
DB09291 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
104943 55084 34 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 55084 34 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10128131 18051 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270272 18051 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380337 57119 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL165465 57119 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380396 57400 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166921 57400 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380082 57792 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167606 57792 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380091 120196 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354772 120196 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380473 120258 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355429 120258 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9896757 203263 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76580 203263 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44241710 83104 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83104 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44314480 102453 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL306311 102453 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
10127439 172518 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452022 172518 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44241710 83104 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83104 0 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71452185 83108 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83108 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10817360 5107 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106078 5107 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10769059 108117 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 108117 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
44307898 199778 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 199778 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL387670 210654 0 None 109 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
132837 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2198 51 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
10128485 148043 7 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3939059 148043 7 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11296094 6338 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082415 6338 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
2102 1162 17 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 1162 17 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 1162 17 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
10621261 36285 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL144793 36285 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9929728 39509 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147619 39509 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408039 75136 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 75136 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408047 96307 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 96307 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
46224962 197713 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 197713 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
10476340 94554 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL25492 94554 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
44380206 57452 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166961 57452 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380132 95967 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL262053 95967 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380290 99615 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287369 99615 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9961955 172194 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL451235 172194 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9810544 203074 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL74956 203074 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44408107 74929 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203740 74929 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL389651 210672 0 None 6 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 444 80 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
10817013 9151 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 9151 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44307821 101631 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 101631 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307819 102110 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102110 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 168687 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 168687 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307820 201931 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 201931 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
11734825 13101 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL119126 13101 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
122187725 122538 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 122538 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
46889690 6858 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084522 6858 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL2371977 208416 0 None 17 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL2419540 208686 0 None 4 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10530375 5538 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 5538 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
44380131 57293 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166828 57293 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380415 119796 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352813 119796 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9831674 103919 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL310334 103919 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
9917970 203235 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76437 203235 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337201 108112 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108112 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44299271 194364 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
CHEMBL56038 194364 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
10231172 138722 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
CHEMBL379038 138722 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
44560755 172619 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452271 172619 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
52946919 18128 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270785 18128 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
46889697 6838 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084438 6838 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
51003055 57549 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672046 57549 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
4898 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
5742 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
6451149 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
CHEMBL206253 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
DB09048 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
54581461 60919 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60919 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
127032533 138245 0 None 10 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
CHEMBL3780776 138245 0 None 10 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
71716116 85920 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313630 85920 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380062 120238 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355295 120238 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9961936 102602 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307498 102602 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315370 203121 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75479 203121 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831075 203432 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78132 203432 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
5759 587 17 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
6450815 587 17 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
CHEMBL204694 587 17 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
44338517 6243 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108200 6243 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358516 167999 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL435796 167999 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44346206 113149 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL332284 113149 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
145948847 166908 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 166908 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10173890 77835 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210591 77835 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 79940 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214388 79940 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46889693 6859 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084523 6859 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44177670 60918 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60918 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL426363 211587 0 None 26 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11801327 9251 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 9251 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44307953 168617 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 168617 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 168617 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9875181 170767 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 170767 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 201872 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 201872 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 202066 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202066 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10762277 13355 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193282 13355 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544660 13355 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44281977 108893 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32197 108893 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52949509 18063 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270371 18063 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
2098 3625 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
36511 3625 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3805 3625 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3835 3625 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
CHEMBL235363 3625 31 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
44315298 102624 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307733 102624 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2372071 208423 11 None - 1 Human 9.0 pKi = 9.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1016/s0960-894x(98)00219-4
9808347 140218 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381832 140218 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127030411 138250 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
CHEMBL3780820 138250 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
52946726 17960 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269638 17960 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL2419537 208683 0 None -32 4 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44241710 83104 0 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 83104 0 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
104943 55084 34 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 55084 34 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10650495 106922 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 106922 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
10626666 108695 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 108695 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
44307741 202081 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 202081 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10303099 7181 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1086003 7181 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
52940877 18123 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270767 18123 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
44216236 6414 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1082737 6414 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380279 57499 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166975 57499 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380414 57832 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167994 57832 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315421 105235 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312612 105235 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
15508105 203113 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75422 203113 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033167 138211 0 None 33 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780408 138211 0 None 33 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
9874206 202066 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 202066 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874473 41549 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41549 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44407998 75132 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 75132 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408046 140200 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 140200 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407971 140210 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 140210 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358335 26642 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136347 26642 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10437488 29697 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138824 29697 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599018 197712 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 197712 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
9826304 186422 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490755 186422 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
2106 3477 3 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9875034 3477 3 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
CHEMBL77023 3477 3 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
44315390 203323 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL77042 203323 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315576 203524 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78851 203524 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10304406 139797 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380705 139797 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
155551678 174849 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
CHEMBL4576324 174849 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
10218122 137842 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL377242 137842 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10239346 138201 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL378027 138201 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
71452185 83108 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 83108 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71453994 83107 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 83107 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44307679 201814 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 201814 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889667 6780 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084165 6780 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
9872249 76182 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206171 76182 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127031644 138292 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 138292 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
127033173 138302 0 None -2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 138302 0 None -2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
145948797 166904 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 166904 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768356 155309 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 155309 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
52943089 17961 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
CHEMBL1269639 17961 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
11490769 83109 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 83109 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71457524 83106 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83106 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71455736 83110 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 83110 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380526 58005 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168272 58005 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315369 102532 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306952 102532 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44305818 14611 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14611 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14611 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
85169 6822 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 6822 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
85169 6822 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 6822 6 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
10204249 75198 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204554 75198 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
85169 6822 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL108438 6822 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
85169 6822 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL108438 6822 6 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
44233410 193911 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 193911 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2102 1162 17 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
5311057 1162 17 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
CHEMBL441225 1162 17 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
44307678 196988 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 196988 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889694 6483 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083052 6483 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
46889698 6839 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084439 6839 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44407902 75058 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 75058 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44338518 7626 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108889 7626 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
22353151 9028 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109937 9028 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358612 30971 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL140080 30971 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358249 116037 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL336305 116037 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
44338359 162865 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL419742 162865 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44380338 119957 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354196 119957 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315297 203149 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL75698 203149 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL589979 214014 10 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None None 10.1021/jm400209h
2098 3625 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
36511 3625 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3805 3625 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3835 3625 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL235363 3625 31 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
22960739 75243 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204714 75243 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
44177770 122473 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 122473 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL589979 214014 10 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589979 214014 10 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
24768354 97504 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL272665 97504 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL2419543 208689 0 None -16 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL261390 208763 0 None -34 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71461646 78484 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2112941 78484 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380289 119736 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352364 119736 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44407939 74993 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203753 74993 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
9850565 75826 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL205829 75826 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44408838 140722 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL383125 140722 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
71455736 83110 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 83110 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10745532 9126 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
CHEMBL110656 9126 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
10555763 107543 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL319476 107543 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
9874473 41549 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41549 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
46889668 6482 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083051 6482 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380080 12121 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL1184507 12121 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352842 12121 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10145229 9068 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9068 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337370 106919 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL318081 106919 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
101658885 160929 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
CHEMBL4127872 160929 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
44233184 193090 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193090 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44380092 119842 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353162 119842 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315589 203120 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75478 203120 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9831707 203308 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76965 203308 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033168 138232 0 None -1 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 138232 0 None -1 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
44315589 203120 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
CHEMBL75478 203120 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
49863734 15145 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15145 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
11793946 37979 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146210 37979 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408045 75239 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 75239 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44358318 30017 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139088 30017 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
22353158 30652 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139750 30652 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358456 118375 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342266 118375 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10741553 13370 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193479 13370 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL544892 13370 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
9892922 100423 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
CHEMBL293844 100423 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
44215305 118736 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343627 118736 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44407907 75330 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 75330 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407917 96097 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 96097 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44408088 139282 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 139282 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44358568 30465 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139499 30465 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
10302076 30502 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139531 30502 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
9892922 100423 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL293844 100423 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
44281685 99556 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286901 99556 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281538 109811 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32385 109811 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
3082491 197627 15 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL590518 197627 15 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL58178 213992 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL591489 214015 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1 10.1021/jm901352b
44380277 58918 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170325 58918 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
73212439 104115 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104782 104115 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44338531 9253 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111304 9253 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
44358346 26566 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
CHEMBL136279 26566 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
46224962 197713 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 197713 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL261608 208764 0 None -3 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44281332 112398 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33106 112398 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44304397 201586 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64698 201586 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44304302 201622 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL64862 201622 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
45379600 197488 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
CHEMBL589543 197488 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
57391133 68010 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68010 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
11799987 5231 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
CHEMBL106754 5231 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
118731115 117655 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408732 117655 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44380107 119582 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350952 119582 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
86274487 159530 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4108583 159530 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
44318455 104185 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL310521 104185 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
44334501 4925 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL105055 4925 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337207 7733 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108955 7733 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44177669 60917 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 60917 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
46889691 6834 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084434 6834 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL589082 214011 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611293 90628 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397493 90628 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44337078 106698 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL316552 106698 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL2372070 208422 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
19610193 106735 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
CHEMBL316740 106735 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
44364001 39649 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147767 39649 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314865 203393 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77752 203393 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281505 116377 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33833 116377 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281334 118876 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34460 118876 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363909 35656 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144223 35656 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44281587 53261 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL160210 53261 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 104117 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 104117 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44408089 139643 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 139643 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408051 140683 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 140683 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44338546 108108 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL320535 108108 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
71717930 85921 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
CHEMBL2313631 85921 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
73350089 88964 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370510 88964 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
73354570 88966 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
CHEMBL2370513 88966 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
44314866 102419 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306039 102419 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314454 105125 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312295 105125 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644614 112199 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288158 112199 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304470 112199 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644604 112234 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288153 112234 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305011 112234 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358589 28791 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL138056 28791 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
9853827 84783 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225588 84783 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
9872676 77811 0 None -3162 17 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
CHEMBL210514 77811 0 None -3162 17 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
53472113 118340 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
CHEMBL3422009 118340 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
2132 3675 48 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
5311424 3675 48 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
CHEMBL10188 3675 48 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
71533722 118342 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
CHEMBL3422010 118342 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
71549769 118350 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
CHEMBL3422018 118350 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
10813332 7677 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108933 7677 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
71533722 118342 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
CHEMBL3422010 118342 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
10745123 10428 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169522 10428 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44337200 9148 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL110766 9148 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363984 35425 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
CHEMBL144011 35425 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
44215306 36928 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145302 36928 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44215303 118444 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342341 118444 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363952 120485 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356508 120485 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
118730933 117641 0 None -389 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 117641 0 None -389 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 117641 0 None -389 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 117641 0 None -389 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
56665366 65562 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835843 65562 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177570 60916 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 60916 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44314873 203072 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL74918 203072 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10395141 203107 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75367 203107 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44282002 124973 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL36462 124973 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 104117 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 104117 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
10651193 7357 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108676 7357 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11273015 57942 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682624 57942 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
132837 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
2110 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
2110 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
219077 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
3480 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
CHEMBL346178 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
DB04872 2910 33 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
44318665 105657 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
CHEMBL313590 105657 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
132837 2198 51 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 2198 51 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 2198 51 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 2198 51 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
44337514 5198 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106555 5198 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
15887536 5341 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107309 5341 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
54397413 90621 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397486 90621 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
44314453 96624 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL267333 96624 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314732 203375 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77592 203375 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318694 105533 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL313297 105533 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
44408864 76153 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206016 76153 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44363990 16121 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL122643 16121 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363982 35423 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144010 35423 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363442 37692 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145959 37692 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
24768353 97286 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
CHEMBL271619 97286 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
44233185 193144 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 193144 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
10394952 104257 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310703 104257 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314486 105163 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312528 105163 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9987474 203115 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75436 203115 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44177670 60918 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 60918 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44281345 109978 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32477 109978 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337353 5340 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL107306 5340 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL388265 210658 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm901352b
44318677 203971 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82278 203971 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
44337080 110096 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL325547 110096 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44380313 57770 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167409 57770 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380095 120330 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355868 120330 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337174 7786 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
CHEMBL108997 7786 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
9566253 75144 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204327 75144 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL3609617 210074 0 None -501 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
73212437 104119 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104786 104119 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
90644632 111441 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288168 111441 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644628 112224 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288165 112224 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3304854 112224 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10141196 26580 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136291 26580 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
135530616 29563 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
CHEMBL138716 29563 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
10230370 30364 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139382 30364 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358408 30740 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139859 30740 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358597 31230 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL140302 31230 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
9852911 98911 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
CHEMBL282618 98911 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
10085946 164777 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL423597 164777 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
25222441 195455 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567849 195455 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
118730936 117644 0 None -16982 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408522 117644 0 None -16982 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
10552479 108503 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321215 108503 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44315267 105013 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312141 105013 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44358421 29524 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138682 29524 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44363962 35686 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144249 35686 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44363949 120416 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356105 120416 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314502 203079 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75018 203079 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10531434 7363 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108683 7363 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
51351504 60270 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760206 60270 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
118731119 117659 0 None -162181 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
CHEMBL3408736 117659 0 None -162181 3 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
44351946 116853 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL339767 116853 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
44281784 112981 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33198 112981 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44318865 204410 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
CHEMBL86053 204410 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
44380094 58421 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168584 58421 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
141952732 119946 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380527 119946 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
CHEMBL354091 119946 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44337467 109713 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL323741 109713 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363936 19820 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL130354 19820 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
9868422 169701 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL444624 169701 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507771 109237 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL322975 109237 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
73353537 90625 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397490 90625 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
10790280 108119 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL320583 108119 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
10649307 109866 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
CHEMBL324177 109866 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
10531273 9094 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
CHEMBL110393 9094 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
71549913 118338 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL3422007 118338 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
44408725 165504 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL425768 165504 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
7088456 197836 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL592133 197836 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44363908 35540 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144116 35540 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363756 39582 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147715 39582 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44138558 192426 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL522292 192426 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10189341 10009 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL115633 10009 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10746177 6930 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL108481 6930 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
11100291 177093 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL464178 177093 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
10649931 7778 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108990 7778 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL2371916 208397 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
20906619 60329 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760338 60329 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
73353047 88962 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370509 88962 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44314547 102389 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL305826 102389 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
25221995 195166 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
CHEMBL565894 195166 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
46228976 197455 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL589329 197455 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
15487997 90617 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397482 90617 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363925 39808 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147924 39808 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314871 105200 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312573 105200 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644630 111439 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288166 111439 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
90644620 112281 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288161 112281 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305870 112281 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44407901 139901 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 139901 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358409 118824 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL344265 118824 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
46224928 197711 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 197711 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
54583959 60330 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760339 60330 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
90644606 112280 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288154 112280 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305869 112280 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338530 9252 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111303 9252 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
11239751 84733 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL225297 84733 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44322610 204909 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
CHEMBL89245 204909 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
86274490 159327 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4106866 159327 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
44315210 102432 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306124 102432 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44409023 139675 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380510 139675 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44560754 172616 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452269 172616 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10359664 113490 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
CHEMBL332644 113490 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
9896563 103291 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 103291 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
9810288 201987 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 201987 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44281633 99512 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286646 99512 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281649 108520 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32124 108520 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281666 108705 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32163 108705 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281650 113285 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33243 113285 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10394882 113300 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33249 113300 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52943090 17962 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269640 17962 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
71453994 83107 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 83107 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380413 96135 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL263214 96135 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380249 119825 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353027 119825 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
127034831 135977 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
CHEMBL3736287 135977 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
72734611 90539 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 90539 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
72734611 90539 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 90539 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
127032846 138249 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 138249 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
145948744 166903 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 166903 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
72734611 90539 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2396664 90539 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
72734611 90539 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2396664 90539 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10769060 5942 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 5942 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
11353915 6860 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084525 6860 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
46889692 6835 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084435 6835 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315209 203193 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76093 203193 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44178113 60920 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 60920 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10793340 5633 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
CHEMBL107830 5633 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
10817098 110026 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL325106 110026 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44380090 120195 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354771 120195 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44315422 102651 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307877 102651 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315591 203256 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76529 203256 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315299 203292 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76823 203292 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9940831 14462 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14462 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14462 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10237920 79417 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212173 79417 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
9927183 193922 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
CHEMBL55591 193922 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
44315572 102495 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306624 102495 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
145948965 166916 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 166916 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
11794060 118680 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343219 118680 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
86302473 112238 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288169 112238 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305156 112238 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408040 74055 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 74055 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 74409 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 74409 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407908 140014 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 140014 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44358317 116024 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL336251 116024 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358425 164883 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL423913 164883 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
145948839 166907 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 166907 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44560774 172391 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451764 172391 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
73348949 90377 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 90377 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
10816496 5117 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
CHEMBL106100 5117 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
46889669 6918 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084771 6918 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315231 104907 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL311712 104907 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44408062 140013 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL381151 140013 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
10600310 85918 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313628 85918 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380248 57840 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168144 57840 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71457524 83106 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 83106 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL3609619 210076 0 None 34 3 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
145948981 166919 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 166919 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
9874473 41549 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41549 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44380732 58668 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL169002 58668 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363436 35472 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144057 35472 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363979 120457 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356268 120457 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10484667 202839 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL72930 202839 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL2370435 208094 0 None -48 2 Guinea pig 7.7 pKi = 7.7 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm00073a022
44314578 203428 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78091 203428 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
13821356 106225 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
CHEMBL3144091 106225 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
44318578 203969 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82274 203969 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
2110 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
219077 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
3480 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
CHEMBL346178 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
DB04872 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
2110 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
219077 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
3480 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
CHEMBL346178 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
DB04872 2910 33 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
44337330 5245 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106816 5245 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
86275688 147763 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
CHEMBL3936869 147763 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
18393120 5173 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106404 5173 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44408736 140342 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL382043 140342 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
44314503 203275 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL76704 203275 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL5083565 213089 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10839138 85919 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313629 85919 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
51351496 60269 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760205 60269 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
86274732 122466 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
CHEMBL3608741 122466 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
86274727 160224 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4114280 160224 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
18546500 76339 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206490 76339 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
46228975 199937 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL605906 199937 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
44334665 167423 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL432007 167423 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337308 5358 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107407 5358 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL2372065 208420 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N1C2CC3CCC2(CS1(=O)=O)C3(C)C)[C@@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
44233184 193090 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 193090 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44314504 102430 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306121 102430 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281357 111228 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32872 111228 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL3609618 210075 0 None -1148 4 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44334664 4457 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
CHEMBL102356 4457 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
86274488 160158 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
CHEMBL4113741 160158 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
44380093 120211 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354892 120211 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10010039 39650 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147769 39650 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44305793 100365 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL293432 100365 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314577 159321 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL41068 159321 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
44314299 203425 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78070 203425 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318269 204262 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL84761 204262 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
44380474 58460 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168769 58460 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10417108 99625 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287454 99625 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314482 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL309087 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380795 204402 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL85980 204402 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337313 108103 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320487 108103 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314482 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL309087 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363963 120751 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL357853 120751 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10417108 99625 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL287454 99625 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL309087 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL309087 103319 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10417108 99625 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287454 99625 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44338532 7534 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108822 7534 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
9801487 205260 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
CHEMBL91418 205260 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
10603383 110846 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
CHEMBL326893 110846 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
73345476 88967 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370514 88967 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
45379601 199047 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL600224 199047 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
73212518 104108 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104774 104108 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
73212440 104113 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
CHEMBL3104780 104113 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
90644624 112251 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288163 112251 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305323 112251 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358385 27241 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL136850 27241 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
73212593 104110 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104776 104110 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212592 104114 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104781 104114 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
145948981 166919 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 166919 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
73353535 90620 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397485 90620 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44281778 109195 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32279 109195 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10794699 9132 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110688 9132 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10530592 10429 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169523 10429 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44334591 106924 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
CHEMBL318093 106924 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
10627789 100099 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
CHEMBL29161 100099 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
52937271 62177 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 62177 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937271 62177 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 62177 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948797 166904 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 166904 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10603365 9184 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL110913 9184 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL261608 208764 0 None -9 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44337023 108174 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320770 108174 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
44462338 204072 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83156 204072 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
145948847 166908 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 166908 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10722607 5119 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL106106 5119 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
10698708 109289 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
CHEMBL323274 109289 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
10697884 163904 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL421408 163904 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44408625 168146 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL436951 168146 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44315590 167234 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL430609 167234 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL2371978 208417 0 None 30 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 444 80 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
9918520 102265 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 102265 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889466 7182 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1086004 7182 0 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
104943 55084 34 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
CHEMBL16192 55084 34 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
44408100 140142 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL381524 140142 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
44407972 140212 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 140212 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44338583 5704 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
CHEMBL107875 5704 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
44358280 26657 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136360 26657 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358334 26817 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136504 26817 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358569 116279 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL337789 116279 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358323 118461 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342443 118461 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44315573 103306 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL308983 103306 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337371 5204 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106572 5204 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
25129135 172018 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172018 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
9918479 57292 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166827 57292 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
22000062 76190 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206268 76190 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948809 166906 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 166906 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44611294 90629 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397494 90629 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10239000 79356 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL211888 79356 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
11467400 6413 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082735 6413 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
9869764 139999 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381058 139999 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948955 166915 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 166915 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44409008 74751 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203605 74751 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10530741 9088 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
CHEMBL110355 9088 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
10115747 140612 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL382771 140612 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL2419540 208686 0 None -4 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
46227360 200886 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200886 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44138555 192559 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL523156 192559 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44408766 96463 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL265986 96463 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507650 162766 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 162766 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
90644635 112196 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288170 112196 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304460 112196 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408033 74408 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 74408 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44337414 9110 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110507 9110 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
46227362 200888 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 200888 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44314154 203348 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77265 203348 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44334845 108407 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
CHEMBL321098 108407 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
3668 1525 36 None -38 11 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 1525 36 None -38 11 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 1525 36 None -38 11 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 1525 36 None -38 11 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
44334666 4544 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
CHEMBL102917 4544 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
90663661 106216 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
CHEMBL3143946 106216 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
118730935 117643 0 None -10715 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408521 117643 0 None -10715 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44334708 4550 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL102932 4550 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
118731117 117657 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408734 117657 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
56682292 65564 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835845 65564 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
90644631 111440 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288167 111440 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358248 26453 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL136187 26453 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
20599018 197712 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 197712 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
44304398 102200 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL304638 102200 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
16655023 106942 1 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
CHEMBL318235 106942 1 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
44408911 140020 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL381179 140020 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
73212517 104109 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104775 104109 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212516 104111 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104777 104111 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
90644626 112243 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288164 112243 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305163 112243 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304340 201173 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL62597 201173 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44337270 108102 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320486 108102 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337007 109906 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL324416 109906 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
52937273 62175 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 62175 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
44281572 109890 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32431 109890 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281776 113740 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33302 113740 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
54581461 60919 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 60919 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
86275687 143097 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
CHEMBL3899877 143097 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
10007108 163402 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
CHEMBL420787 163402 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
44380475 58461 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168770 58461 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314476 104590 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL311387 104590 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
24768355 168318 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 168318 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768355 168318 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 168318 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44281713 99189 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284396 99189 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281788 99511 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286640 99511 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73353536 90622 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397487 90622 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
2110 2910 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
219077 2910 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
3480 2910 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL346178 2910 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
DB04872 2910 33 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
10600014 167296 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL431070 167296 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
10007326 106370 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL314499 106370 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
44314481 203218 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL76334 203218 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
145948839 166907 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 166907 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
145948968 166917 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 166917 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
45271306 193989 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 193989 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
118730934 117642 0 None -363 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 117642 0 None -363 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
51003494 57999 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682680 57999 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
44337355 5259 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106877 5259 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
118731114 117654 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408731 117654 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44363948 36133 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144668 36133 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363912 118239 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL341843 118239 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10507772 109252 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL323044 109252 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44336987 108449 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL321154 108449 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
9809308 204001 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82552 204001 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
4189 205185 91 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205185 91 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205185 91 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44408628 139820 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380827 139820 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380764 120203 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354822 120203 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363978 40234 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL148282 40234 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
11801041 109952 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL324667 109952 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44334654 107702 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL319653 107702 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
52937270 62176 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 62176 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948809 166906 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 166906 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314945 203277 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL76727 203277 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
44281392 99483 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286433 99483 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44323563 205276 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
CHEMBL91475 205276 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
90644629 111155 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3286415 111155 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10300825 29714 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL138839 29714 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44304301 201617 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64839 201617 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
90644616 112226 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288159 112226 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304856 112226 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644610 112239 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288156 112239 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305158 112239 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
2110 2910 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
219077 2910 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
3480 2910 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
CHEMBL346178 2910 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
DB04872 2910 33 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
44338557 9243 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111244 9243 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44363926 38818 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146882 38818 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314867 156773 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL407749 156773 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44408755 74673 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203481 74673 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10032693 109261 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32309 109261 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
107686 3315 37 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 3315 37 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 3315 37 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
9939040 4926 5 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 4926 5 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL2419544 208690 0 None -14 3 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10602943 106921 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 106921 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
9824321 75076 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204206 75076 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9846661 76207 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206294 76207 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380457 57793 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167613 57793 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9939307 201784 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL66106 201784 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10531666 9086 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110340 9086 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL3609615 210072 0 None -24 4 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44318312 104374 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL311027 104374 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
86275451 159534 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL4108623 159534 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
57396389 68011 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
CHEMBL1916636 68011 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
44407890 74809 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL203655 74809 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44337208 5153 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106300 5153 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44282003 99636 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287523 99636 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334500 4453 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
CHEMBL102332 4453 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
44281744 112962 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33194 112962 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363877 38898 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146947 38898 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44409004 74075 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL202720 74075 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
46227361 200887 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 200887 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44318565 204203 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL84161 204203 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL2372339 208467 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
44318497 204272 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL84873 204272 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
145948965 166916 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 166916 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314872 96411 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL265499 96411 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337202 7878 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109053 7878 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337079 106699 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL316553 106699 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44337024 108176 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL320771 108176 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
145948744 166903 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 166903 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10769914 110649 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL326429 110649 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL2112592 207486 0 None -1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44380596 59025 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170727 59025 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44408726 76192 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL206274 76192 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
10091563 39457 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL147543 39457 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
44314861 167206 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL430416 167206 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
11801965 5134 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106217 5134 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10603279 7925 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
CHEMBL109080 7925 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
9939307 201784 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 201784 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44282001 99334 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285422 99334 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281571 109887 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32430 109887 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281976 110072 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32537 110072 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10321715 26485 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136213 26485 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44338618 108825 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL321892 108825 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
10393853 109211 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL322885 109211 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
2755911 75073 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75073 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 75073 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 75073 48 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 75073 48 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2042018 75073 48 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
15887537 108546 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 108546 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
145948968 166917 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 166917 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44364030 36402 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144887 36402 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44282004 121234 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL35891 121234 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
90644608 112197 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288155 112197 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304468 112197 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338652 108110 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL320544 108110 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
46224897 197423 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
CHEMBL589130 197423 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
73350555 90623 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397488 90623 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
2098 3625 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
36511 3625 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3805 3625 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3835 3625 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
CHEMBL235363 3625 31 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
44334581 5147 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL106273 5147 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
2090 2716 20 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
5311312 2716 20 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
CHEMBL437797 2716 20 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
445694 119511 75 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL350320 119511 75 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
11305162 74406 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203109 74406 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44334489 106801 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL317209 106801 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
44337354 5369 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
CHEMBL107469 5369 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
44314834 203429 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78092 203429 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281771 99166 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284269 99166 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
7088460 197590 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590275 197590 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
70689371 77961 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
CHEMBL2110361 77961 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
46227360 200886 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 200886 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
18546495 140169 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL381744 140169 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44380680 57268 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166759 57268 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44318593 167420 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL431974 167420 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
44281787 162636 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL418224 162636 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
49863733 15144 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15144 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
118730932 117640 0 None -2951 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 117640 0 None -2951 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44364003 118477 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342572 118477 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10295489 139799 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL380716 139799 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
44281957 99342 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285475 99342 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10010096 99415 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285986 99415 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
24768356 155309 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 155309 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
10675169 108159 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL320758 108159 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44408846 140002 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381081 140002 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
14991605 90627 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397492 90627 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10229773 75135 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204296 75135 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
44407906 74344 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 74344 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408048 140015 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 140015 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44407903 140178 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 140178 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44338586 6792 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL108422 6792 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44338584 8058 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109183 8058 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10187704 118906 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL344847 118906 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 197676 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 197676 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
118730933 117641 0 None -389 3 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 117641 0 None -389 3 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
10578261 9078 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 9078 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
127033168 138232 0 None -1 3 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 138232 0 None -1 3 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
56668794 65563 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835844 65563 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177145 194045 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 194045 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9874473 41549 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41549 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
71549635 160315 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
CHEMBL4115030 160315 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
145948955 166915 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 166915 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314597 103859 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310019 103859 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
118731113 117653 0 None -43651 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408730 117653 0 None -43651 3 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44314298 203422 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78065 203422 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10001148 51155 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL158212 51155 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
90644622 112235 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288162 112235 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305013 112235 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358413 26686 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136389 26686 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358551 29106 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138335 29106 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 197676 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 197676 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
2089 2715 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3795 2715 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
5311311 2715 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL217406 2715 21 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
90644612 112210 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288157 112210 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304538 112210 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644618 112253 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288160 112253 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305331 112253 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304381 101602 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
CHEMBL302163 101602 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
7037588 197591 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590276 197591 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44318874 203943 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82065 203943 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
3198 203792 73 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 203792 73 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 203792 73 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
131954513 161517 31 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 161517 31 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
11683187 198240 35 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL594828 198240 35 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
8867347 60264 6 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760200 60264 6 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
44408821 75026 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203928 75026 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
73352066 90626 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397491 90626 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363435 36942 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145314 36942 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380733 58293 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168437 58293 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363983 17967 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL126970 17967 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44281958 109186 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32273 109186 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337289 107539 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL319474 107539 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
46227363 197974 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 197974 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
10651575 5070 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL105847 5070 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129133 188290 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 188290 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 188290 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 188290 0 None -1122 5 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44380069 57297 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166842 57297 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
127031644 138292 0 None -1 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 138292 0 None -1 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
44337288 7948 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109092 7948 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
52937467 62179 0 None -9 4 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 62179 0 None -9 4 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL2419538 208684 0 None -117 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
10140125 27058 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136709 27058 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
20811360 30097 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139150 30097 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358247 118489 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342602 118489 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44338640 167515 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL432627 167515 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44337324 6618 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108364 6618 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314548 102423 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306052 102423 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281516 99407 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285929 99407 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73352065 90618 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397483 90618 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44550460 195351 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567198 195351 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
25129135 172018 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 172018 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
73347011 88965 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370511 88965 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44409000 168364 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL438801 168364 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
118731118 117658 0 None -1202 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
CHEMBL3408735 117658 0 None -1202 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
44318486 104929 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
CHEMBL311946 104929 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
118731116 117656 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408733 117656 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44281743 99165 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284244 99165 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334630 109154 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL322453 109154 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
10721590 7567 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108847 7567 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10746828 6849 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL108448 6849 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL2372068 208421 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(Cc2ccccc2)[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
73212515 104112 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104778 104112 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44338510 8531 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL109514 8531 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
57394644 68008 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 68008 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
44334582 161132 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL413383 161132 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
73212519 104107 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104773 104107 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44304323 100105 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
CHEMBL291650 100105 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
90417914 118347 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
CHEMBL3422015 118347 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
9887650 16457 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16457 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44380794 119764 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352614 119764 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10078301 118714 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343447 118714 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364002 120522 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356796 120522 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
127033173 138302 0 None -2 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 138302 0 None -2 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
9872295 12498 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL1187084 12498 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL489924 12498 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44334499 106803 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
CHEMBL317238 106803 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
127032846 138249 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 138249 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
85169 6822 6 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL108438 6822 6 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
9846662 75544 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL204958 75544 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
3668 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
3668 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
5311081 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL333357 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL589982 1525 36 None -38 11 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
10299289 192005 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL521605 192005 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10232846 113604 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL332793 113604 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10767720 78267 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
CHEMBL2112476 78267 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
73351579 88961 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
CHEMBL2370507 88961 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
10792994 7418 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108725 7418 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44380763 119515 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350360 119515 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281476 99456 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286235 99456 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314533 105186 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312539 105186 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314946 203344 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77235 203344 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
1016 3678 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3678 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3678 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3678 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3678 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3678 75 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2247 502 77 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 502 77 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 502 77 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 502 77 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 502 77 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2812 4696 96 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4696 96 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44407932 75529 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204918 75529 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9940831 14462 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14462 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14462 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10032406 39699 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147824 39699 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314868 155145 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL405129 155145 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314487 102427 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306097 102427 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281672 113012 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33215 113012 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL387816 210655 0 None 23 2 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611292 90619 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397484 90619 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44305818 14611 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14611 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14611 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL2419539 208685 0 None -81 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44337173 6596 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108350 6596 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
122187725 122538 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 122538 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44281358 97798 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL274557 97798 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337266 5211 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106608 5211 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44407896 138119 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL377712 138119 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44408697 75065 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204165 75065 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
73355028 90624 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397489 90624 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2111789 207465 0 None -3 2 Human 4.0 pKi = 4.0 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44408910 140748 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL383289 140748 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
10409484 189059 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
CHEMBL515179 189059 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
44281753 99343 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285476 99343 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
43815 186327 58 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL1708 186327 58 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL490 186327 58 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
132837 2198 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 2198 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 2198 51 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9329 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
9894349 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
CHEMBL339486 3672 3 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
23653789 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
9280 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
CHEMBL447955 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
DB12973 3517 19 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
2098 3625 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
36511 3625 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3805 3625 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3835 3625 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
CHEMBL235363 3625 31 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
9278 3777 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
9916461 3777 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
CHEMBL3544984 3777 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
DB12580 3777 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
2098 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 3625 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
None 214423 0 125I-Bolton Hunter 2 5 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
135413536 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 444 80 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
202 1475 0 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 1475 0 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 1475 0 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 1475 0 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 1475 0 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 201368 82 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 201368 82 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 201428 51 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 201428 51 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 215584 0 3H-SP -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
119376 1803 41 3H-SUBSTANCE P -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 1803 41 3H-SUBSTANCE P -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 1803 41 3H-SUBSTANCE P -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 1967 106 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 1967 106 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 1967 106 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 1967 106 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 1967 106 3H-Sar9SP -14454 45 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
243 3141 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 3141 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 3141 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 3141 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 3141 85 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
21830793 91389 5 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 91389 5 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
133090 97958 18 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 97958 18 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
44208932 140163 6 UNDEFINED -120226 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 140163 6 UNDEFINED -120226 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
1973 201781 12 125I-[SAR9, Met(O2)11]-SP -3 37 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 201781 12 125I-[SAR9, Met(O2)11]-SP -3 37 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 201781 12 125I-[SAR9, Met(O2)11]-SP -3 37 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
5079497 214293 0 125I-[MePhe7]-NKB -1445 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 841 26 8 10 -0.0 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O None
None 214348 0 3H-Leu,4,5 Substance P -1 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 164 3 1 3 0.8 C1CNC1COC2=CN=CC=C2 None
119380 214349 0 3H-Leu,4,5 Substance P -1 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 166 1 0 3 1.8 CC1=NOC(=C1)C2CCCN2C None
None 214742 0 3H-SUBSTANCE P -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
None 214294 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214294 0 3H-SUBSTANCE P -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214294 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
2098 3625 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 3625 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 3625 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 3625 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 3625 31 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
None 214294 0 125I-Bolton Hunter -1202 8 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214423 0 125I-Bolton Hunter -1412 5 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 214424 0 125I-Bolton Hunter -2 6 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 195556 21 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195556 21 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214294 0 125I-Bolton Hunter -354 8 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214424 0 125I-Bolton Hunter -2 6 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 195556 21 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195556 21 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214294 0 3H-Sar9,Met(O2)11-Substance P -354 8 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214423 0 125I-Bolton Hunter -2 5 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 214294 0 125I-Bolton Hunter -354 8 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214294 0 125I-Bolton Hunter -354 8 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
9850582 195556 21 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195556 21 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
2812 4696 96 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 4696 96 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
2247 502 77 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 502 77 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 502 77 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 502 77 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 502 77 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
1016 3678 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 3678 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 3678 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 3678 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 3678 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 3678 75 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
3198 203792 73 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 203792 73 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 203792 73 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4189 205185 91 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 205185 91 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 205185 91 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
None 214291 0 125I-[MePhe7]-NKB -676 4 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 1210 38 14 16 -1.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N None
9850582 195556 21 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 195556 21 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 214294 0 125I-Bolton Hunter -354 8 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 214292 0 125I-[MePhe7]-NKB -851 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 214294 0 125I-[MePhe7]-NKB -354 8 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
4898 2714 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
5742 2714 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
6451149 2714 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
CHEMBL206253 2714 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
DB09048 2714 78 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
71544786 216020 0 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 689 8 2 5 6.4 CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 None
10311306 3303 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5027 3303 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5749 3303 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
CHEMBL3707331 3303 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
DB09291 3303 47 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
23725089 789 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
4401 789 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
5758 789 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
9917021 789 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
CHEMBL1672054 789 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
DB06634 789 8 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
None 214424 0 125I-Bolton Hunter 2 6 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
135413536 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
135413536 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
230 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
230 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
3490 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
3490 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
6918365 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
6918365 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
CHEMBL1471 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1471 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
DB00673 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB00673 444 80 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
10158788 3658 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5746 3658 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5752 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
6918331 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
CHEMBL522302 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
DB12436 3930 20 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
2087 1881 0 None 31 4 Human 10.8 pKi = 10.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 3515 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 3515 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2095 3515 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2095 3515 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL1885865 3515 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL1885865 3515 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5759 587 17 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
6450815 587 17 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
CHEMBL204694 587 17 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
4898 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
5742 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
6451149 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
CHEMBL206253 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
DB09048 2714 78 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
107967 1608 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
2114 1608 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
CHEMBL1416993 1608 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
10311306 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5027 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5749 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
CHEMBL3707331 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
DB09291 3303 47 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
10462 1977 7 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
9808518 1977 7 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
CHEMBL206488 1977 7 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
5754 3203 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
9917716 3203 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
5757 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
5757 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
9832383 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
9832383 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
CHEMBL522987 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
CHEMBL522987 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
DB11949 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
DB11949 3911 10 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
23725089 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
23725089 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
4401 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
4401 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
5758 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
5758 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
9917021 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
9917021 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
CHEMBL1672054 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
CHEMBL1672054 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
DB06634 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
DB06634 789 8 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
2102 1162 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
2102 1162 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
5311057 1162 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
5311057 1162 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
CHEMBL441225 1162 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
CHEMBL441225 1162 17 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
188927 1579 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
5751 1579 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
CHEMBL515966 1579 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
3086681 2231 14 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
3510 2231 14 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
CHEMBL42407 2231 14 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
2090 2716 20 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311312 2716 20 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL437797 2716 20 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2110 2910 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
219077 2910 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
3480 2910 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
CHEMBL346178 2910 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
DB04872 2910 33 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
104974 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
104974 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2111 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
2111 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3481 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
3481 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
CHEMBL308148 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
CHEMBL308148 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
DB06660 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
DB06660 3406 27 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2105 3213 0 None - 1 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12206858
2089 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2089 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
2089 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2089 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3795 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3795 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
3795 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
3795 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311311 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
5311311 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
5311311 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5311311 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL217406 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL217406 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
CHEMBL217406 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL217406 2715 21 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2106 3477 3 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
9875034 3477 3 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
CHEMBL77023 3477 3 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
2098 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2098 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
36511 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
36511 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3805 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3805 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3835 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3835 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
CHEMBL235363 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL235363 3625 31 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501