Ligand source activities (1 row/activity)



Get vendors


Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
155531953 171170 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171170 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 174812 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 174812 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11332190 894 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 894 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 894 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 894 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 894 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 894 10 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 213379 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538662 171841 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 171841 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5088494 213379 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 213027 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168275711 189613 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
CHEMBL5174724 189613 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
168293038 191515 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5203480 191515 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5077507 212720 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5077507 212720 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 213027 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168291719 191351 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
CHEMBL5200919 191351 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
168269858 189372 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5170854 189372 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
168292803 191455 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 191455 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
168292522 191434 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202223 191434 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 169843 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 169843 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155530073 170916 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 170916 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 169863 2 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169863 2 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5085505 213187 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5085505 213187 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 212932 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 212932 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 213574 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
168286108 190784 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
CHEMBL5192437 190784 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
168284015 190647 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 190647 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5092307 213574 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155537257 171691 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 171691 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155548932 173240 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 173240 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
168280867 190159 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
CHEMBL5183095 190159 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
155544237 172785 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 172785 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11936 971 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
162679547 971 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
CHEMBL5180985 971 4 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
168282236 190359 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5185986 190359 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155535518 171492 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 171492 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5092307 213574 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155535988 171533 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 171533 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 213053 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 213053 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155518713 169702 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 169702 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL5089041 213409 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5089041 213409 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 213574 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 213379 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 213379 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538284 171823 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 171823 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155569501 175608 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 175608 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
11332190 894 10 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 894 10 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 894 10 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 894 10 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 894 10 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 894 10 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
155554828 174038 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174038 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 213053 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 213053 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
162649940 179405 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 179405 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162656586 180305 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4757632 180305 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162674241 182624 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796012 182624 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671889 182265 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791599 182265 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168284015 190647 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 190647 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155548932 173240 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 173240 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
162654876 179997 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4754349 179997 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
155531953 171170 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4467290 171170 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162655374 180218 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4756747 180218 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162677428 182904 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4799609 182904 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155531953 171170 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171170 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168292803 191455 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 191455 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 169843 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 169843 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519969 169785 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4447627 169785 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
162649290 179571 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4748968 179571 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162663355 181318 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4779379 181318 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162654668 179337 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746196 179337 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
162654348 180014 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754530 180014 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648650 179304 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4745883 179304 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162660049 180768 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4763169 180768 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168282945 190154 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5183004 190154 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519352 169863 2 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169863 2 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155531953 171170 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 171170 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162659559 180699 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4762253 180699 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671930 182312 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4792296 182312 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162673878 182396 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4793378 182396 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162673026 182476 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4794289 182476 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162657219 180278 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4757393 180278 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155538662 171841 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 171841 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654669 179338 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746197 179338 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162649970 179469 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747813 179469 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155569501 175608 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 175608 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
162653266 179811 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752027 179811 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155543662 172627 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4522836 172627 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155530073 170916 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 170916 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155537257 171691 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 171691 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155567133 175296 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4586253 175296 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
162671660 182290 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791896 182290 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162661813 180864 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4764426 180864 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155526368 170569 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
CHEMBL4458521 170569 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
162662697 181398 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4780439 181398 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162641724 181665 4 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 181665 4 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
162652190 179755 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4751327 179755 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162670503 182374 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4793031 182374 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155554828 174038 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174038 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654920 179973 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754029 179973 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155535988 171533 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 171533 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162674418 182657 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796399 182657 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155518713 169702 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 169702 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155538284 171823 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 171823 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155550367 173708 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
CHEMBL4549880 173708 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
155554828 174038 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 174038 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162649458 179473 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747865 179473 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155550204 173269 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4539132 173269 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
162645029 178873 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4740735 178873 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155544237 172785 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 172785 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 169863 2 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169863 2 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168276231 189818 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5177967 189818 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155564611 174942 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4578235 174942 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155538662 171841 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 171841 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 174812 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 174812 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155544237 172785 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 172785 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168286341 191085 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5196772 191085 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
162668192 181838 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4786002 181838 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162653225 179810 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752019 179810 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162647018 178945 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4741497 178945 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162672104 182266 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791613 182266 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648558 179317 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746011 179317 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155525712 170498 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4457246 170498 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155516007 169453 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4442745 169453 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162675068 182683 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796678 182683 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168294228 191616 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
CHEMBL5204898 191616 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
155563693 174812 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 174812 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155535518 171492 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 171492 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
2945 893 0 None -14 2 Human 8.0 pEC50 = 8.0 Functional
In a β-arrestin recruitment assay.In a β-arrestin recruitment assay.
Guide to Pharmacology None None None None 25437209
2945 893 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14530373
2945 893 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
2945 893 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
2945 893 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
1518 365 1 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
9781 365 1 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
CHEMBL1358898 365 1 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
11936 971 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
162679547 971 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
CHEMBL5180985 971 4 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894


Get vendors


Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
162649940 179405 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 179405 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
155519352 169863 2 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 169863 2 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162641724 181665 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 181665 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
9784 3716 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 14530373
9784 3716 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 24659779
11332190 894 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
11332190 894 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
3422 894 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
3422 894 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
CHEMBL5081975 894 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
CHEMBL5081975 894 10 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
10473088 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
10473088 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
10473088 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
3333 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
3333 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
3333 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
CHEMBL1742483 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
CHEMBL1742483 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
CHEMBL1742483 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
DB13105 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
DB13105 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
DB13105 3255 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
2945 893 0 None 1 2 Human 8.3 pKd = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312