GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	9827294	73502	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL2018953	73502	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.ejmech.2016.02.058
	127046612	139207	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798452	139207	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127046614	139383	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799578	139383	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	127047356	139091	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	139091	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	44288958	168151	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL43698	168151	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	127047440	139064	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	542	7	2	8	4.4	COc1cc2nc(N3CCC(N(C)C(=O)[C@H]4CCCN4)CC3)nc(Nc3ccc(Cl)cc3F)c2cc1OC	10.1016/j.ejmech.2016.02.058
	CHEMBL3797462	139064	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	542	7	2	8	4.4	COc1cc2nc(N3CCC(N(C)C(=O)[C@H]4CCCN4)CC3)nc(Nc3ccc(Cl)cc3F)c2cc1OC	10.1016/j.ejmech.2016.02.058
	127047612	139349	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799393	139349	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	44288959	164744	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42334	164744	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	10238794	162273	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	473	7	2	6	4.3	O=S(=O)(Nc1ncc(Cl)nc1OCc1ccccc1CO)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172769	162273	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	473	7	2	6	4.3	O=S(=O)(Nc1ncc(Cl)nc1OCc1ccccc1CO)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10195057	161935	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	444	6	1	6	4.2	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4167445	161935	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	444	6	1	6	4.2	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	23585443	537	7	None	3	3	Mouse	9.0	pIC50	=	9	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	537	7	None	3	3	Mouse	9.0	pIC50	=	9	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	537	7	None	3	3	Mouse	9.0	pIC50	=	9	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	145959198	161612	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	369	4	1	5	2.9	COc1nc(F)c(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4162364	161612	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	369	4	1	5	2.9	COc1nc(F)c(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10308720	540	35	None	2	3	Mouse	8.0	pIC50	=	8	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	540	35	None	2	3	Mouse	8.0	pIC50	=	8	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	540	35	None	2	3	Mouse	8.0	pIC50	=	8	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	10309893	162126	2	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4170431	162126	2	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	11525206	134692	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Calcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPRCalcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPR	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL372399	134692	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Calcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPRCalcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPR	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44581043	187241	0	None	1	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496152	187241	0	None	1	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581068	187331	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496787	187331	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	25212472	192035	0	None	-2	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL521737	192035	0	None	-2	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	59456023	86714	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	516	8	2	7	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)=O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326612	86714	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	516	8	2	7	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)=O)cccc32)c1	10.1021/jm301572h
	59456042	86716	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	532	8	3	7	4.5	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)(C)O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326614	86716	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	532	8	3	7	4.5	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)(C)O)cccc32)c1	10.1021/jm301572h
	59456012	86717	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326615	86717	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	71584536	86731	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccnc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326628	86731	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccnc(CNC(C)=O)c1	10.1021/jm301572h
	59168189	161865	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1	10.1021/acsmedchemlett.7b00315
	CHEMBL4166246	161865	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1	10.1021/acsmedchemlett.7b00315
	118706823	112464	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	5	2	5	4.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL3310832	112464	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	5	2	5	4.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(C)C	10.1016/j.bmc.2014.05.021
	10309983	161552	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	417	4	1	6	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4161268	161552	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	417	4	1	6	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/acsmedchemlett.7b00315
	145949792	162144	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	425	5	1	6	3.8	COc1nc(Br)cnc1NS(=O)(=O)c1sccc1-c1ccccc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4170786	162144	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	425	5	1	6	3.8	COc1nc(Br)cnc1NS(=O)(=O)c1sccc1-c1ccccc1	10.1021/acsmedchemlett.7b00315
	137642528	157707	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1ccc2c(cnn2C)c1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	CHEMBL4088688	157707	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1ccc2c(cnn2C)c1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	137659242	158609	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	458	6	2	9	2.3	COc1nn(C)c2nc(NC3COC3)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4098333	158609	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	458	6	2	9	2.3	COc1nn(C)c2nc(NC3COC3)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	145955299	162027	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	368	4	1	6	2.6	COc1nc(Cl)cnc1NS(=O)(=O)c1ccnc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4168920	162027	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	368	4	1	6	2.6	COc1nc(Cl)cnc1NS(=O)(=O)c1ccnc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	155520262	169890	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	578	7	0	8	5.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(C)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4448901	169890	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	578	7	0	8	5.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(C)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	71461546	83910	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	640	11	2	5	6.3	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmc.2012.03.069
	CHEMBL2216810	83910	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	640	11	2	5	6.3	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmc.2012.03.069
	25141301	185296	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	185296	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	185296	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL486840	185296	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	118706824	112465	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	443	5	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1COC1	10.1016/j.bmc.2014.05.021
	CHEMBL3310833	112465	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	443	5	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1COC1	10.1016/j.bmc.2014.05.021
	59456067	73518	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018968	73518	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	136116031	86361	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	CHEMBL2321924	86361	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	59456019	86733	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326630	86733	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	10195081	161599	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	445	6	1	7	3.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cncnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4162097	161599	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	445	6	1	7	3.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cncnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10309206	161844	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4165939	161844	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	59168214	162475	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	6	1	6	3.0	CCOc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1	10.1021/acsmedchemlett.7b00315
	CHEMBL4175972	162475	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	6	1	6	3.0	CCOc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1	10.1021/acsmedchemlett.7b00315
	134210781	177624	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(C4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4649666	177624	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(C4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	71584537	86732	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)n1	10.1021/jm301572h
	CHEMBL2326629	86732	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)n1	10.1021/jm301572h
	10150948	161414	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4159115	161414	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1Cl	10.1021/acsmedchemlett.7b00315
	10287210	162529	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4176859	162529	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1	10.1021/acsmedchemlett.7b00315
	137652824	158203	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	357	3	1	6	2.5	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4093994	158203	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	357	3	1	6	2.5	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	10126022	162212	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1ccsc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4171873	162212	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1ccsc1	10.1021/acsmedchemlett.7b00315
	137632634	155839	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	356	3	1	5	3.1	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ccnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4066451	155839	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	356	3	1	5	3.1	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ccnc21	10.1016/j.bmc.2017.07.052
	155543648	172612	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(N3CCC(N4CCCCC4)C(C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4522547	172612	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(N3CCC(N4CCCCC4)C(C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	70685474	73515	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	518	8	1	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN(C)C(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018965	73515	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	518	8	1	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN(C)C(C)=O)c1	10.1016/j.bmcl.2012.02.104
	44561334	175639	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	CHEMBL459464	175639	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	44561260	188447	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	384	6	2	6	5.1	COc1cc2nc(NC3CCCC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL509396	188447	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	384	6	2	6	5.1	COc1cc2nc(NC3CCCC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44562238	186163	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	524	8	1	8	5.0	COc1cc2nc(N3CCCN(CCN4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488855	186163	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	524	8	1	8	5.0	COc1cc2nc(N3CCCN(CCN4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	185296	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	185296	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	185845	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	185845	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	185296	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL486840	185296	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	16724339	185845	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL487635	185845	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156013953	176623	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	418	5	0	6	4.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(CN(C)C)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4635359	176623	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	418	5	0	6	4.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(CN(C)C)C3)cnc12	10.1021/acs.jmedchem.0c00988
	10416	1841	23	None	309	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	46861584	1841	23	None	309	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	CHEMBL2018969	1841	23	None	309	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	44288958	168151	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmc.2012.03.069
	CHEMBL43698	168151	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmc.2012.03.069
	25141190	1120	24	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	9478	1120	24	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	CHEMBL508207	1120	24	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	44581102	187179	0	None	1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495736	187179	0	None	1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156017568	177237	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	494	5	0	8	4.3	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4643839	177237	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	494	5	0	8	4.3	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	59455988	86723	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	CHEMBL2326620	86723	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	59456014	86724	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	CHEMBL2326621	86724	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	59456103	86725	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	CHEMBL2326622	86725	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	58054368	86727	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326624	86727	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	59456058	86736	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326633	86736	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	56849395	86748	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326926	86748	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	10308720	540	35	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	540	35	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	540	35	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	10308963	161624	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(F)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4162555	161624	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(F)c1Cl	10.1021/acsmedchemlett.7b00315
	145951541	162148	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	409	6	1	5	4.3	CC(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4170833	162148	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	409	6	1	5	4.3	CC(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44562237	186136	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	510	8	1	8	4.7	COc1cc2nc(N3CCCN(CCN4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488691	186136	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	510	8	1	8	4.7	COc1cc2nc(N3CCCN(CCN4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	71525425	132278	0	None	-446	5	Human	5.8	pIC50	=	5.8	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	509	8	3	9	2.7	Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	CHEMBL3701196	132278	0	None	-446	5	Human	5.8	pIC50	=	5.8	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	509	8	3	9	2.7	Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	59455992	73506	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018957	73506	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	23585443	537	7	None	-16	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	537	7	None	-16	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	537	7	None	-16	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	71584535	86730	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cc(CNC(C)=O)ccn1	10.1021/jm301572h
	CHEMBL2326627	86730	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cc(CNC(C)=O)ccn1	10.1021/jm301572h
	137633709	156066	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	373	4	2	6	2.5	COc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4069103	156066	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	373	4	2	6	2.5	COc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	145955692	161933	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4167390	161933	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1Cl	10.1021/acsmedchemlett.7b00315
	145971718	162506	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	453	7	1	5	4.5	CCCCOc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4176441	162506	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	453	7	1	5	4.5	CCCCOc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	118706827	112468	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	461	7	4	7	2.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(CO)CO	10.1016/j.bmc.2014.05.021
	CHEMBL3310836	112468	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	461	7	4	7	2.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(CO)CO	10.1016/j.bmc.2014.05.021
	137643503	157850	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	3	3	6	2.2	O=S(=O)(Nc1ncnc2[nH]nc(O)c12)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	CHEMBL4090166	157850	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	3	3	6	2.2	O=S(=O)(Nc1ncnc2[nH]nc(O)c12)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	155561858	175172	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4583503	175172	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134325276	174892	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4577319	174892	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134211225	177341	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4645325	177341	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	25141190	1120	24	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	9478	1120	24	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	CHEMBL508207	1120	24	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	25141190	1120	24	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	9478	1120	24	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	CHEMBL508207	1120	24	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	44561294	172401	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	481	7	1	7	5.6	COc1cc2nc(N3CCC(N(C)C4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL451783	172401	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	481	7	1	7	5.6	COc1cc2nc(N3CCC(N(C)C4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44581121	187670	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	553	10	2	8	5.0	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL499852	187670	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	553	10	2	8	5.0	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	16724339	185845	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	185845	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	185845	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL487635	185845	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	25212379	187269	0	None	2	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496356	187269	0	None	2	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	16724339	185845	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL487635	185845	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	25212472	192035	0	None	2	2	Mouse	7.7	pIC50	=	7.7	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL521737	192035	0	None	2	2	Mouse	7.7	pIC50	=	7.7	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	59455975	86715	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326613	86715	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	71583488	86718	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	CHEMBL2326616	86718	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	11244702	161771	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	339	4	1	6	2.7	COc1nccnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4164738	161771	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	339	4	1	6	2.7	COc1nccnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	59168158	161989	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C	10.1021/acsmedchemlett.7b00315
	CHEMBL4168237	161989	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C	10.1021/acsmedchemlett.7b00315
	10215932	72765	1	None	-22	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at CCR4 in human primary Th2 cells by chemotaxis assayAntagonist activity at CCR4 in human primary Th2 cells by chemotaxis assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL2011441	72765	1	None	-22	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at CCR4 in human primary Th2 cells by chemotaxis assayAntagonist activity at CCR4 in human primary Th2 cells by chemotaxis assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	118706818	112460	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C	10.1016/j.bmc.2014.05.021
	CHEMBL3310827	112460	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C	10.1016/j.bmc.2014.05.021
	118706829	112470	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	484	5	2	6	2.8	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CN(C(C)=O)C1	10.1016/j.bmc.2014.05.021
	CHEMBL3310838	112470	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	484	5	2	6	2.8	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CN(C(C)=O)C1	10.1016/j.bmc.2014.05.021
	137643926	157668	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	6	2	8	2.0	COc1nn(CC(=O)O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4088207	157668	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	6	2	8	2.0	COc1nn(CC(=O)O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	10194488	161617	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1021/acsmedchemlett.7b00315
	CHEMBL4162503	161617	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1021/acsmedchemlett.7b00315
	10194274	161821	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	1	6	3.2	CCOc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4165500	161821	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	1	6	3.2	CCOc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	118706820	112462	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	415	4	1	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)n(C)c(=O)n2C	10.1016/j.bmc.2014.05.021
	CHEMBL3310829	112462	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	415	4	1	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)n(C)c(=O)n2C	10.1016/j.bmc.2014.05.021
	118706826	112467	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	458	7	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CCN(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL3310835	112467	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	458	7	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CCN(C)C	10.1016/j.bmc.2014.05.021
	137661320	158523	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2ccccc21	10.1016/j.bmc.2017.07.052
	CHEMBL4097341	158523	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2ccccc21	10.1016/j.bmc.2017.07.052
	118706819	112461	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2[nH]c(=O)n(C)c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310828	112461	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2[nH]c(=O)n(C)c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	23585443	537	7	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	537	7	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	537	7	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59168181	161485	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	391	5	1	5	3.3	C#CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160218	161485	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	391	5	1	5	3.3	C#CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	16724339	185845	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	185845	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	185845	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL487635	185845	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44561335	175641	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	393	4	1	5	4.8	c1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	CHEMBL459465	175641	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	393	4	1	5	4.8	c1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	44561588	192946	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL529664	192946	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	134210933	176922	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639600	176922	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134225255	176741	4	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	176741	4	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134211098	177460	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647117	177460	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	58054516	73508	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	CHEMBL2018959	73508	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	44562156	186137	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488704	186137	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44561217	188517	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL510375	188517	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	134324821	170526	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.5	CC1CN(c2cnc3c(C(N)=O)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4457732	170526	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.5	CC1CN(c2cnc3c(C(N)=O)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	134324770	170366	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	CHEMBL4455432	170366	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	134225247	177079	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641595	177079	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	134325106	170675	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4460062	170675	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	25212379	187269	0	None	2	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496356	187269	0	None	2	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581044	192835	0	None	-3	2	Mouse	6.6	pIC50	=	6.6	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	CHEMBL526474	192835	0	None	-3	2	Mouse	6.6	pIC50	=	6.6	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	134325169	171833	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	CC1CN(c2cnc3cnn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4476671	171833	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	CC1CN(c2cnc3cnn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	134211185	176569	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4634054	176569	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	25141301	185296	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	185296	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	185296	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL486840	185296	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156010350	176498	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633133	176498	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44562155	186039	0	None	19	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488018	186039	0	None	19	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	102143549	112471	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310839	112471	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054475	86726	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326623	86726	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	58597374	162018	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	363	5	2	6	2.1	COc1nc(CO)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4168775	162018	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	363	5	2	6	2.1	COc1nc(CO)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	134335265	174394	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	497	4	0	7	5.3	CC1CN(c2cnc3c(C#N)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4566241	174394	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	497	4	0	7	5.3	CC1CN(c2cnc3c(C#N)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	71583704	86729	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	9	2	8	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC2COC2)c1	10.1021/jm301572h
	CHEMBL2326626	86729	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	9	2	8	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC2COC2)c1	10.1021/jm301572h
	71583039	86749	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	474	7	2	6	4.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3ccccc32)c1	10.1021/jm301572h
	CHEMBL2326927	86749	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	474	7	2	6	4.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3ccccc32)c1	10.1021/jm301572h
	137647817	157003	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	429	5	1	8	2.5	COc1nn(C2COC2)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4080352	157003	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	429	5	1	8	2.5	COc1nn(C2COC2)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137653647	158486	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	2.9	CCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4096860	158486	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	2.9	CCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	137661613	158664	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	415	5	1	7	3.5	COc1nn(C(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4098813	158664	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	415	5	1	7	3.5	COc1nn(C(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	155518637	169743	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.2	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(N3CCC(N4CCCCC4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	CHEMBL4446924	169743	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.2	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(N3CCC(N4CCCCC4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	44561137	186127	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL488640	186127	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	134325016	174071	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	CHEMBL4558456	174071	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	59456051	73517	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018967	73517	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	142450222	169096	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	484	4	1	6	4.5	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(C3=CCN(C(=O)[C@H]4CCCCN4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	CHEMBL4437594	169096	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	484	4	1	6	4.5	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(C3=CCN(C(=O)[C@H]4CCCCN4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	156010372	176524	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4633494	176524	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44562191	186164	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488857	186164	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	58834906	92198	0	None	-467	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	604	8	1	6	6.2	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1	10.1021/jm401101p
	CHEMBL2435853	92198	0	None	-467	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	604	8	1	6	6.2	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1	10.1021/jm401101p
	134210845	177465	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647188	177465	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44430312	86818	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL233046	86818	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	9959269	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL2018954	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	9959269	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	CHEMBL2018954	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	9959269	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2017.07.052
	9959269	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	CHEMBL2018954	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2017.07.052
	CHEMBL2018954	73503	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	23585443	537	7	None	-16	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	537	7	None	-16	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	537	7	None	-16	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59168106	161523	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	2	6	2.7	COc1nc(CO)c(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160846	161523	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	2	6	2.7	COc1nc(CO)c(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	23585446	162294	1	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1ncc(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4173046	162294	1	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1ncc(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	59168165	162429	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	521	6	1	5	5.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccc(Br)c1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4175323	162429	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	521	6	1	5	5.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccc(Br)c1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	25212472	192035	0	None	-2	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL521737	192035	0	None	-2	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	134210626	176721	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4636749	176721	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44562189	185983	0	None	7	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487835	185983	0	None	7	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44561333	189276	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2c1	10.1016/j.bmc.2008.05.036
	CHEMBL516936	189276	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2c1	10.1016/j.bmc.2008.05.036
	10308720	540	35	None	-4	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	540	35	None	-4	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	540	35	None	-4	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59456102	73514	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018964	73514	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	59456102	73514	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2018964	73514	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	58054384	86709	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	CHEMBL2326608	86709	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	71583489	86719	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCO2)c1	10.1021/jm301572h
	CHEMBL2326617	86719	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCO2)c1	10.1021/jm301572h
	59456010	86721	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	CHEMBL2326619	86721	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	118706817	112459	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310826	112459	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	23585443	537	7	None	-16	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	537	7	None	-16	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	537	7	None	-16	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59456021	86712	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	7	2	7	4.1	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C#N)cccc32)c1	10.1021/jm301572h
	CHEMBL2326610	86712	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	7	2	7	4.1	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C#N)cccc32)c1	10.1021/jm301572h
	137632888	155980	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.6	COCCn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4068045	155980	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.6	COCCn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	137644457	157758	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	402	4	2	8	2.1	COc1nn(C)c2nc(N)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4089151	157758	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	402	4	2	8	2.1	COc1nn(C)c2nc(N)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137632974	155794	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	3.3	COc1nn(C)c2nc(NC(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4065904	155794	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	3.3	COc1nn(C)c2nc(NC(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137652382	156840	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)cccc21	10.1016/j.bmc.2017.07.052
	CHEMBL4078359	156840	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)cccc21	10.1016/j.bmc.2017.07.052
	10173173	161685	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)ccc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4163571	161685	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)ccc1Cl	10.1021/acsmedchemlett.7b00315
	145950145	162319	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	279	6	1	5	1.7	CCCCS(=O)(=O)Nc1ncc(Cl)nc1OC	10.1021/acsmedchemlett.7b00315
	CHEMBL4173424	162319	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	279	6	1	5	1.7	CCCCS(=O)(=O)Nc1ncc(Cl)nc1OC	10.1021/acsmedchemlett.7b00315
	145950218	162403	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	399	4	1	6	3.5	CSc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4174872	162403	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	399	4	1	6	3.5	CSc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	134325076	171609	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4473604	171609	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134325041	174450	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4567398	174450	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44561172	173128	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	485	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCC(F)CC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL453594	173128	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	485	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCC(F)CC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	70685473	73500	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018951	73500	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	44562189	185983	0	None	7	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487835	185983	0	None	7	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	70681287	73510	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	CHEMBL2018960	73510	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	134335394	171766	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	CHEMBL4475665	171766	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	156018849	177323	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4645037	177323	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134335393	169534	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4443688	169534	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44562192	185185	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486656	185185	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	134211221	177104	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4641873	177104	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	134325003	174800	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4575089	174800	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	156015374	177031	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4640909	177031	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	16041411	92130	0	None	-4168	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	572	8	1	6	5.6	O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1	10.1021/jm401101p
	CHEMBL2434978	92130	0	None	-4168	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	572	8	1	6	5.6	O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1	10.1021/jm401101p
	11525206	134692	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of chemotaxis of murine CCR4 transfected L1.2 cellsInhibition of chemotaxis of murine CCR4 transfected L1.2 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL372399	134692	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of chemotaxis of murine CCR4 transfected L1.2 cellsInhibition of chemotaxis of murine CCR4 transfected L1.2 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	155557193	173943	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	CHEMBL4555534	173943	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	70689680	73504	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018955	73504	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	25141190	1120	24	None	1	2	Mouse	7.4	pIC50	=	7.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	9478	1120	24	None	1	2	Mouse	7.4	pIC50	=	7.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	CHEMBL508207	1120	24	None	1	2	Mouse	7.4	pIC50	=	7.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	10416	1841	23	None	309	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	46861584	1841	23	None	309	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	CHEMBL2018969	1841	23	None	309	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	59456111	86720	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	CHEMBL2326618	86720	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	59456026	86734	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326631	86734	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59455990	86735	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326632	86735	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	10288569	161479	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	461	4	1	6	3.5	COc1nc(Br)cnc1NS(=O)(=O)c1sc(Cl)cc1Br	10.1021/acsmedchemlett.7b00315
	CHEMBL4160139	161479	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	461	4	1	6	3.5	COc1nc(Br)cnc1NS(=O)(=O)c1sc(Cl)cc1Br	10.1021/acsmedchemlett.7b00315
	10287192	161495	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	5	2	6	2.4	COc1nc(CO)c(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160463	161495	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	5	2	6	2.4	COc1nc(CO)c(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10193586	162260	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(C)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172568	162260	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(C)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44581103	187180	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495737	187180	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	118706828	112469	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	442	5	3	6	2.6	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CNC1	10.1016/j.bmc.2014.05.021
	CHEMBL3310837	112469	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	442	5	3	6	2.6	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CNC1	10.1016/j.bmc.2014.05.021
	56848673	86745	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326923	86745	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	56848670	86747	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326925	86747	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	118706825	112466	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	6	2	5	3.9	CCCn1c(=O)[nH]c2cc(NS(=O)(=O)c3cccc(Cl)c3Cl)c(OC)cc21	10.1016/j.bmc.2014.05.021
	CHEMBL3310834	112466	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	6	2	5	3.9	CCCn1c(=O)[nH]c2cc(NS(=O)(=O)c3cccc(Cl)c3Cl)c(OC)cc21	10.1016/j.bmc.2014.05.021
	137656805	159167	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	7	1	8	2.5	COc1nn(CCN(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4104585	159167	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	7	1	8	2.5	COc1nn(CCN(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	10417	1049	5	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	134324842	1049	5	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	CHEMBL4459231	1049	5	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	155541406	172416	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4518040	172416	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	58054487	73513	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018963	73513	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	134211126	176985	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4640439	176985	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	155531126	171031	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4465359	171031	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44581043	187241	0	None	-1	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496152	187241	0	None	-1	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44562191	186164	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488857	186164	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44581042	187240	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496151	187240	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581102	187179	0	None	-1	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495736	187179	0	None	-1	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	71555361	132790	0	None	-234	5	Human	6.4	pIC50	=	6.4	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	564	8	3	10	2.4	Cc1ccc([C@H](Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	CHEMBL3704573	132790	0	None	-234	5	Human	6.4	pIC50	=	6.4	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	564	8	3	10	2.4	Cc1ccc([C@H](Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	134210778	177118	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4642090	177118	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	118706821	112463	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	444	6	3	6	1.9	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CC(N)=O	10.1016/j.bmc.2014.05.021
	CHEMBL3310830	112463	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	444	6	3	6	1.9	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CC(N)=O	10.1016/j.bmc.2014.05.021
	134336138	176911	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639418	176911	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134324973	169808	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4447900	169808	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	70693879	73059	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2016602	73059	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	44581042	187240	0	None	6	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496151	187240	0	None	6	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44561561	178413	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL470962	178413	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	10215932	72765	1	None	22	2	Mouse	8.3	pIC50	=	8.3	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL2011441	72765	1	None	22	2	Mouse	8.3	pIC50	=	8.3	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	9827294	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	CHEMBL2018953	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	9827294	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018953	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	9827294	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2017.07.052
	9827294	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	CHEMBL2018953	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2017.07.052
	CHEMBL2018953	73502	1	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	118706831	112473	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310841	112473	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	56848674	86746	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	542	9	3	7	3.9	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326924	86746	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	542	9	3	7	3.9	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59168115	161734	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1ncc(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4164247	161734	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1ncc(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44430315	11746	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL1182360	11746	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233047	11746	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	11223594	70725	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195298	70725	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	10308720	540	35	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	540	35	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	540	35	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	10308720	540	35	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	540	35	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	540	35	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	137638825	156316	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	1.4	COc1nn(CC(N)=O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4071815	156316	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	1.4	COc1nn(CC(N)=O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	59168213	161590	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	5	1	7	2.0	COc1nc(S(C)(=O)=O)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4161922	161590	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	5	1	7	2.0	COc1nc(S(C)(=O)=O)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	145955410	161835	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	381	4	1	5	3.3	CCc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4165828	161835	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	381	4	1	5	3.3	CCc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	10309892	161904	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1	10.1021/acsmedchemlett.7b00315
	CHEMBL4167021	161904	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1	10.1021/acsmedchemlett.7b00315
	156018931	177285	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	540	6	0	6	6.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4644412	177285	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	540	6	0	6	6.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44581043	187241	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496152	187241	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44561363	189082	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	466	6	1	6	6.3	COc1cc2nc(C3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL515355	189082	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	466	6	1	6	6.3	COc1cc2nc(C3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44581044	192835	0	None	3	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	CHEMBL526474	192835	0	None	3	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	11496063	76751	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	CHEMBL207642	76751	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	155540774	171937	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	CHEMBL4483537	171937	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	155543069	172607	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	459	5	2	5	4.7	C[C@@H](Nc1cncc(C2=CCN(C(=O)[C@H]3CCCCN3)CC2)n1)c1ccc(Cl)cc1Cl	10.1021/acs.jmedchem.9b00506
	CHEMBL4522437	172607	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	459	5	2	5	4.7	C[C@@H](Nc1cncc(C2=CCN(C(=O)[C@H]3CCCCN3)CC2)n1)c1ccc(Cl)cc1Cl	10.1021/acs.jmedchem.9b00506
	59456003	73501	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018952	73501	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	44562235	185868	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	495	6	1	7	5.9	COc1cc2nc(N3CCCN(C4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487665	185868	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	495	6	1	7	5.9	COc1cc2nc(N3CCCN(C4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44561332	175638	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL459463	175638	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	58835024	92197	0	None	-398	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	570	8	1	6	5.5	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1	10.1021/jm401101p
	CHEMBL2435852	92197	0	None	-398	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	570	8	1	6	5.5	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1	10.1021/jm401101p
	134324891	173985	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4556507	173985	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	25212379	187269	0	None	-2	2	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496356	187269	0	None	-2	2	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	134210775	177192	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	7	0	8	4.8	CCOC(=O)CN1CCCC(C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4643066	177192	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	7	0	8	4.8	CCOC(=O)CN1CCCC(C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	134211057	177041	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641127	177041	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	59455976	86713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	CHEMBL2326611	86713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	59456050	86728	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	CHEMBL2326625	86728	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	118706816	112458	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2014.05.021
	CHEMBL3310825	112458	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2014.05.021
	118706816	112458	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2017.07.052
	CHEMBL3310825	112458	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2017.07.052
	44562192	185185	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486656	185185	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44581103	187180	0	None	6	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495737	187180	0	None	6	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581068	187331	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496787	187331	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	137636569	155321	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	4	1	7	2.5	COc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4060413	155321	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	4	1	7	2.5	COc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	10215932	72765	1	None	-22	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL2011441	72765	1	None	-22	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	145958908	161529	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	401	4	1	5	3.6	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(C(F)(F)F)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160965	161529	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	401	4	1	5	3.6	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(C(F)(F)F)c1Cl	10.1021/acsmedchemlett.7b00315
	145951136	162190	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	358	4	1	6	2.5	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C#N	10.1021/acsmedchemlett.7b00315
	CHEMBL4171579	162190	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	358	4	1	6	2.5	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C#N	10.1021/acsmedchemlett.7b00315
	137632086	155884	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	401	4	1	7	2.8	COc1nn(C)c2nc(C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4066934	155884	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	401	4	1	7	2.8	COc1nn(C)c2nc(C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137654717	158174	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	5	1	8	2.5	COc1nn(C)c2nc(N(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4093509	158174	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	5	1	8	2.5	COc1nn(C)c2nc(N(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137652889	158347	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	1.7	CNC(=O)Cn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4095437	158347	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	1.7	CNC(=O)Cn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	145951247	162366	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1c(Cl)cccc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4174254	162366	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1c(Cl)cccc1Cl	10.1021/acsmedchemlett.7b00315
	10193603	162381	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1cccs1	10.1021/acsmedchemlett.7b00315
	CHEMBL4174488	162381	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1cccs1	10.1021/acsmedchemlett.7b00315
	44581044	192835	0	None	3	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	CHEMBL526474	192835	0	None	3	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	692856	140819	16	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL383736	140819	16	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	134325269	170114	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	516	5	1	7	4.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(=O)O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4451802	170114	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	516	5	1	7	4.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(=O)O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134210768	176870	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4638846	176870	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	134325215	174396	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4566304	174396	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44562155	186039	0	None	19	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488018	186039	0	None	19	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44430312	86818	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL233046	86818	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	11525206	134692	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL372399	134692	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	127047356	139091	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	139091	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	127045756	139326	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799266	139326	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127046614	139383	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799578	139383	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	10287052	161816	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1ncc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4165356	161816	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1ncc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	11234202	162341	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	373	4	1	6	3.3	COc1nc(Cl)cnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4173861	162341	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	373	4	1	6	3.3	COc1nc(Cl)cnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44562189	185983	0	None	-7	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487835	185983	0	None	-7	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	156010600	176554	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633920	176554	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	118706830	112472	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310840	112472	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054532	73512	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018962	73512	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	58054387	86710	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326609	86710	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	59456098	86737	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1ccc(F)c2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326634	86737	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1ccc(F)c2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	137639968	156124	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	416	5	2	8	2.5	CNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4069639	156124	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	416	5	2	8	2.5	CNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	137639432	156276	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	4	1	8	1.9	COc1nn(C)c2ncnc(NS(=O)(=O)c3ccc(Cl)s3)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4071299	156276	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	4	1	8	1.9	COc1nn(C)c2ncnc(NS(=O)(=O)c3ccc(Cl)s3)c12	10.1016/j.bmc.2017.07.052
	10308962	162481	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1F	10.1021/acsmedchemlett.7b00315
	CHEMBL4176082	162481	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1F	10.1021/acsmedchemlett.7b00315
	137634526	155376	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	417	5	1	8	2.5	COc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4060967	155376	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	417	5	1	8	2.5	COc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	137632304	155924	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1nn(C)c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4067451	155924	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1nn(C)c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137647898	157187	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.5	COCCOc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4082318	157187	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.5	COCCOc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137644970	157937	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	5	2	6	2.9	CCOc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4091069	157937	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	5	2	6	2.9	CCOc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	59168178	162422	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	343	4	1	5	2.0	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4175259	162422	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	343	4	1	5	2.0	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1	10.1021/acsmedchemlett.7b00315
	137637450	155266	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	460	8	2	9	2.5	COCCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4059913	155266	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	460	8	2	9	2.5	COCCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	145955548	162050	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	423	5	1	5	4.7	CC(C)(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169258	162050	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	423	5	1	5	4.7	CC(C)(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	134225259	177160	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4642563	177160	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44430315	11746	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL1182360	11746	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233047	11746	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	155548141	173205	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@@H](N4CCCCC4)[C@@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4537681	173205	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@@H](N4CCCCC4)[C@@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44562155	186039	0	None	-19	2	Mouse	6.1	pIC50	=	6.1	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488018	186039	0	None	-19	2	Mouse	6.1	pIC50	=	6.1	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	134324996	171167	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	540	4	0	6	6.5	CC1CN(c2cnc3c(C(F)(F)F)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4467274	171167	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	540	4	0	6	6.5	CC1CN(c2cnc3c(C(F)(F)F)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	134210954	177226	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643609	177226	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44581042	187240	0	None	6	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496151	187240	0	None	6	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581102	187179	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495736	187179	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156012782	176780	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637695	176780	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134210898	177199	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643158	177199	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	59455974	73511	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018961	73511	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	44562236	186135	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	512	10	1	8	4.9	CCN(CC)CCN1CCCN(c2nc(Nc3ccc(Cl)cc3)c3cc(OC)c(OC)cc3n2)CC1	10.1016/j.bmc.2008.07.062
	CHEMBL488690	186135	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	512	10	1	8	4.9	CCN(CC)CCN1CCCN(c2nc(Nc3ccc(Cl)cc3)c3cc(OC)c(OC)cc3n2)CC1	10.1016/j.bmc.2008.07.062
	44562190	185984	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	471	8	2	8	3.9	COc1cc2nc(N3CCC(N(C)CCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487836	185984	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	471	8	2	8	3.9	COc1cc2nc(N3CCC(N(C)CCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	59455974	73511	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018961	73511	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	59456102	73514	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018964	73514	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	59456003	73501	0	None	-	1	Human	5.8	pKd	=	5.8	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018952	73501	0	None	-	1	Human	5.8	pKd	=	5.8	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	59456051	73517	0	None	-	1	Human	5.7	pKd	=	5.7	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018967	73517	0	None	-	1	Human	5.7	pKd	=	5.7	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	9959269	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	CHEMBL2018954	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	58054516	73508	0	None	-	1	Human	5.6	pKd	=	5.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	CHEMBL2018959	73508	0	None	-	1	Human	5.6	pKd	=	5.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	9827294	73502	1	None	-	1	Human	7.3	pKd	=	7.3	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018953	73502	1	None	-	1	Human	7.3	pKd	=	7.3	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	10416	1841	23	None	309	2	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	46861584	1841	23	None	309	2	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	CHEMBL2018969	1841	23	None	309	2	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	59456067	73518	0	None	-	1	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018968	73518	0	None	-	1	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	70685473	73500	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018951	73500	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	70689680	73504	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018955	73504	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	49798461	10578	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	443	5	1	5	5.3	Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1170725	10578	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	443	5	1	5	5.3	Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	49798437	10444	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	515	8	3	6	4.4	O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1169660	10444	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	515	8	3	6	4.4	O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	49798349	10676	0	None	-	1	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	471	6	2	4	5.9	O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1171786	10676	0	None	-	1	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	471	6	2	4	5.9	O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	16124598	10614	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	472	6	2	5	5.3	O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1171008	10614	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	472	6	2	5	5.3	O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	5280343	187681	119	None	-16	7	Human	8.3	pIC50	=	8.3	Functional	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	Drug Central	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL1520590	187681	119	None	-16	7	Human	8.3	pIC50	=	8.3	Functional	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	Drug Central	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL50	187681	119	None	-16	7	Human	8.3	pIC50	=	8.3	Functional	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	Drug Central	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	2812	4696	96	None	3	39	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	CHEMBL104	4696	96	None	3	39	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	4410	3076	99	None	-18	5	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	65015	3076	99	None	-18	5	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	844	3076	99	None	-18	5	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	CHEMBL18442	3076	99	None	-18	5	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	DB06809	3076	99	None	-18	5	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	3793	201510	70	None	-1	3	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	None
	45039617	201510	70	None	-1	3	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	None
	CHEMBL64391	201510	70	None	-1	3	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	None
	12153	1627	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patentAntagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patent	Guide to Pharmacology	542	6	1	7	4.9	C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO	None
	134210715	1627	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patentAntagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patent	Guide to Pharmacology	542	6	1	7	4.9	C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO	None
	10417	1049	5	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.	Guide to Pharmacology	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	31259550
	134324842	1049	5	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.	Guide to Pharmacology	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	31259550
	CHEMBL4459231	1049	5	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.	Guide to Pharmacology	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	31259550
	10308720	540	35	None	-2	3	Dog	7.6	pIC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9678	540	35	None	-2	3	Dog	7.6	pIC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4169247	540	35	None	-2	3	Dog	7.6	pIC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	25141190	1120	24	None	-1	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	19081254
	9478	1120	24	None	-1	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	19081254
	CHEMBL508207	1120	24	None	-1	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	19081254
	10308720	540	35	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9678	540	35	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4169247	540	35	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	10308720	540	35	None	2	3	Mouse	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9678	540	35	None	2	3	Mouse	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4169247	540	35	None	2	3	Mouse	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	23585443	537	7	None	-3	3	Dog	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9679	537	7	None	-3	3	Dog	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4172635	537	7	None	-3	3	Dog	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	23585443	537	7	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9679	537	7	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4172635	537	7	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	797	817	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9430724
	23585443	537	7	None	3	3	Mouse	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9679	537	7	None	3	3	Mouse	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4172635	537	7	None	3	3	Mouse	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	798	831	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9430724

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44410965	76691	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	5	2	4	4.1	CCNCc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207290	76691	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	5	2	4	4.1	CCNCc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44406335	73571	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL202085	73571	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44288732	100687	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(F)cc2F)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL295560	100687	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(F)cc2F)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288854	164498	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42266	164498	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	44288730	165408	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(F)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42523	165408	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(F)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289282	169198	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	617	11	3	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc2[nH]ccc2c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44390	169198	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	617	11	3	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc2[nH]ccc2c1	10.1016/j.bmcl.2004.01.072
	5481702	204099	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptor	ChEMBL	556	8	0	4	5.3	CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00639-9
	CHEMBL83338	204099	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptor	ChEMBL	556	8	0	4	5.3	CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00639-9
	5280343	187681	119	None	-	32	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL1520590	187681	119	None	-	32	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL50	187681	119	None	-	32	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	71720517	86565	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	86565	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	44288960	163233	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42060	163233	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1Cl	10.1016/j.bmcl.2004.01.072
	44400830	70876	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	10	1	4	5.1	CCN(CC)CCCC(C)Nc1nc(Cc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195665	70876	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	10	1	4	5.1	CCN(CC)CCCC(C)Nc1nc(Cc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	5280343	187681	119	None	-	32	Human	4.0	pIC50	=	4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL1520590	187681	119	None	-	32	Human	4.0	pIC50	=	4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL50	187681	119	None	-	32	Human	4.0	pIC50	=	4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	44288899	100782	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	13	2	6	3.6	O=C(C[C@H]1S[C@H](CCc2ccccc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL296245	100782	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	13	2	6	3.6	O=C(C[C@H]1S[C@H](CCc2ccccc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288863	161510	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	6	3.5	O=C(C[C@H]1S[C@H](C2CCCCC2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL416069	161510	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	6	3.5	O=C(C[C@H]1S[C@H](C2CCCCC2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289207	167617	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	633	9	1	5	6.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(Cc2cccc(CN3CCOCC3)c2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43330	167617	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	633	9	1	5	6.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(Cc2cccc(CN3CCOCC3)c2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288557	169706	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccoc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44463	169706	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccoc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	5280343	187681	119	None	-	32	Human	5.0	pIC50	=	5.0	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL1520590	187681	119	None	-	32	Human	5.0	pIC50	=	5.0	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL50	187681	119	None	-	32	Human	5.0	pIC50	=	5.0	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	134211221	177104	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4641873	177104	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	45104526	199015	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	479	3	3	7	3.8	Cc1c(N2CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL599995	199015	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	479	3	3	7	3.8	Cc1c(N2CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	44288959	164744	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42334	164744	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44430304	151578	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2c(ncn2CC)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL396786	151578	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2c(ncn2CC)n1	10.1016/j.bmcl.2006.10.091
	11285792	864	30	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	801	864	30	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	CHEMBL2110727	864	30	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	DB11758	864	30	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	44288962	99995	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	10	2	5	4.5	CN(C)CC(=O)NCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL290845	99995	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	10	2	5	4.5	CN(C)CC(=O)NCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44288985	154990	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	668	14	2	9	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1OC	10.1016/j.bmcl.2004.01.072
	CHEMBL40427	154990	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	668	14	2	9	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1OC	10.1016/j.bmcl.2004.01.072
	44288961	155079	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1ccccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL40468	155079	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1ccccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44289214	156749	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40771	156749	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288776	165755	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	10	2	8	3.3	O=C(CN1C(=O)[C@@H](CC(=O)Nc2nccs2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL42722	165755	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	10	2	8	3.3	O=C(CN1C(=O)[C@@H](CC(=O)Nc2nccs2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44288731	169760	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	11	2	6	3.9	Cc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(C)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44472	169760	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	11	2	6	3.9	Cc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(C)c1	10.1016/j.bmcl.2004.01.072
	44288963	170403	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	11	2	7	3.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccs1	10.1016/j.bmcl.2004.01.072
	CHEMBL44561	170403	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	11	2	7	3.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccs1	10.1016/j.bmcl.2004.01.072
	45104751	199224	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	1	1	5	1.9	Cc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL601651	199224	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	1	1	5	1.9	Cc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	3793	201510	70	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	201510	70	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	201510	70	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	134210626	176721	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4636749	176721	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	155557193	173943	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	CHEMBL4555534	173943	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	44561588	192946	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL529664	192946	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44406247	140653	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	463	5	0	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(OCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL382826	140653	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	463	5	0	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(OCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	71454500	78567	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113068	78567	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2005.02.084
	44289275	101030	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL298035	101030	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	44289277	162939	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)ccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42021	162939	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)ccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289072	168763	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.3	O=C(C[C@H]1S[C@H](c2cccc(C(F)(F)F)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44187	168763	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.3	O=C(C[C@H]1S[C@H](c2cccc(C(F)(F)F)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44411038	76432	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	471	8	1	4	7.6	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)no2)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL206921	76432	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	471	8	1	4	7.6	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)no2)c1C	10.1016/j.bmcl.2006.01.126
	3793	201510	70	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	201510	70	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	201510	70	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44289062	163096	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42044	163096	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.072
	44289064	170354	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	660	12	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCCc1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44553	170354	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	660	12	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCCc1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2004.01.072
	45104634	199042	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	2	6	1.7	CCN1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	CHEMBL600196	199042	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	2	6	1.7	CCN1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	45104523	200016	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	437	3	3	6	4.0	Cc1c(N2CCN(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL606421	200016	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	437	3	3	6	4.0	Cc1c(N2CCN(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	134225247	177079	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641595	177079	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	134210845	177465	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647188	177465	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	155540774	171937	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	CHEMBL4483537	171937	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	44411321	137884	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	509	8	1	4	8.6	FC(F)(F)c1ccccc1CN(Cc1csc(Nc2cccc3ccccc23)n1)CC1CCCCC1	10.1016/j.bmcl.2006.01.126
	CHEMBL377421	137884	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	509	8	1	4	8.6	FC(F)(F)c1ccccc1CN(Cc1csc(Nc2cccc3ccccc23)n1)CC1CCCCC1	10.1016/j.bmcl.2006.01.126
	44430311	151836	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	460	11	2	6	5.9	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2cccnc2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL397028	151836	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	460	11	2	6	5.9	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2cccnc2n1	10.1016/j.bmcl.2006.10.091
	44288958	168151	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL43698	168151	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44288981	164994	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	7	2	5	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42419	164994	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	7	2	5	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	25141301	185296	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	185296	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	156015374	177031	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4640909	177031	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44411492	138354	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3cnccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL378272	138354	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3cnccc23)n1	10.1016/j.bmcl.2006.01.126
	44288943	164066	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42162	164066	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2004.01.072
	44288913	168713	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(F)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44143	168713	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(F)c1	10.1016/j.bmcl.2004.01.072
	44401027	70193	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL194775	70193	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	134325041	174450	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4567398	174450	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	45104946	199026	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	371	5	0	6	2.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCC3)ccc12	10.1021/jm901652p
	CHEMBL600018	199026	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	371	5	0	6	2.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCC3)ccc12	10.1021/jm901652p
	45104635	199043	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	420	2	2	6	3.9	Cc1c(N2CCN(c3cccc(C(F)(F)F)c3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL600197	199043	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	420	2	2	6	3.9	Cc1c(N2CCN(c3cccc(C(F)(F)F)c3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	45104422	199537	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	406	3	2	6	2.9	Cc1c(N2CCN(C(=O)/C=C/c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL603701	199537	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	406	3	2	6	2.9	Cc1c(N2CCN(C(=O)/C=C/c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	45104527	199016	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	409	3	3	6	2.5	Cc1c(N2CCN(C(=O)NCc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL599996	199016	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	409	3	3	6	2.5	Cc1c(N2CCN(C(=O)NCc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	2812	4696	96	None	-	34	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1021/jm301749y
	CHEMBL104	4696	96	None	-	34	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1021/jm301749y
	71720517	86565	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	86565	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	45104848	199400	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	3	0	5	2.3	CCOc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL602887	199400	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	3	0	5	2.3	CCOc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	10417	1049	5	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	134324842	1049	5	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	CHEMBL4459231	1049	5	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	9814022	76743	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	268	3	1	3	5.2	CC(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207589	76743	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	268	3	1	3	5.2	CC(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	692856	140819	16	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL383736	140819	16	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	71461653	78565	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccccc2Cl)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113066	78565	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccccc2Cl)c1	10.1016/j.bmcl.2005.02.084
	134335393	169534	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4443688	169534	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	11496063	76751	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	CHEMBL207642	76751	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	44288978	168160	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	585	10	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43706	168160	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	585	10	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288827	168225	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43758	168225	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	71458049	78574	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	359	11	1	4	4.7	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(F)cc2)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113075	78574	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	359	11	1	4	4.7	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(F)cc2)c1	10.1016/j.bmcl.2005.02.084
	44561561	178413	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL470962	178413	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44288791	99720	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	12	2	6	3.3	CC(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL288256	99720	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	12	2	6	3.3	CC(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44430309	86782	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ccccc12	10.1016/j.bmcl.2006.10.091
	CHEMBL232841	86782	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ccccc12	10.1016/j.bmcl.2006.10.091
	134325106	170675	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4460062	170675	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	45104945	199025	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	385	5	0	6	2.7	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCCC3)ccc12	10.1021/jm901652p
	CHEMBL600017	199025	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	385	5	0	6	2.7	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCCC3)ccc12	10.1021/jm901652p
	44430312	86818	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL233046	86818	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	44288880	101075	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	5	5.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL298454	101075	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	5	5.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	3793	201510	70	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	201510	70	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	201510	70	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44411325	168301	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1	10.1016/j.bmcl.2006.01.126
	CHEMBL438248	168301	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1	10.1016/j.bmcl.2006.01.126
	44288879	168766	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL44188	168766	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44400833	70348	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	392	11	1	5	5.1	CCN(CC)CCCC(C)Nc1nc(COc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195061	70348	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	392	11	1	5	5.1	CCN(CC)CCCC(C)Nc1nc(COc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	44401066	125881	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CN(C)CCCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL365155	125881	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CN(C)CCCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44289208	163283	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	7	1	5	4.6	CN1CCN(C(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	CHEMBL42065	163283	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	7	1	5	4.6	CN1CCN(C(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	71452724	78571	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113072	78571	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2)c1	10.1016/j.bmcl.2005.02.084
	45104633	198707	18	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	290	1	2	6	1.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL598070	198707	18	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	290	1	2	6	1.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	9943773	76936	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	286	2	1	3	5.1	CC(C)(C)c1csc(Nc2cccc3c2CCCC3)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL208249	76936	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	286	2	1	3	5.1	CC(C)(C)c1csc(Nc2cccc3c2CCCC3)n1	10.1016/j.bmcl.2006.01.126
	44411033	76981	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	299	3	1	4	5.2	CCn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	CHEMBL208458	76981	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	299	3	1	4	5.2	CCn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	44430302	86676	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2nc[nH]c12	10.1016/j.bmcl.2006.10.091
	CHEMBL232639	86676	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2nc[nH]c12	10.1016/j.bmcl.2006.10.091
	44289116	168703	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	11	2	6	3.7	CC(C)(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL44134	168703	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	11	2	6	3.7	CC(C)(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	176	394	63	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	394	63	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	394	63	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	394	63	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	394	63	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	134324891	173985	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4556507	173985	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	9922232	165195	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	296	3	1	3	5.6	CC(C)(C)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL424689	165195	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	296	3	1	3	5.6	CC(C)(C)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44289186	164519	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42270	164519	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1	10.1016/j.bmcl.2004.01.072
	44289105	97967	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	656	13	2	6	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL275593	97967	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	656	13	2	6	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288818	154861	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40366	154861	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44400899	70224	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	390	11	1	4	5.3	CCN(CC)CCCC(C)Nc1nc(CCc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL194930	70224	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	390	11	1	4	5.3	CCN(CC)CCCC(C)Nc1nc(CCc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	44288912	165521	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	678	13	2	7	4.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCNS(=O)(=O)CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42586	165521	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	678	13	2	7	4.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCNS(=O)(=O)CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134211126	176985	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4640439	176985	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	10308720	540	35	None	-	0	Dog	7.6	pIC50	=	7.6	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	540	35	None	-	0	Dog	7.6	pIC50	=	7.6	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	540	35	None	-	0	Dog	7.6	pIC50	=	7.6	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	44289241	99935	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL290201	99935	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288996	168783	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL44198	168783	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	44289039	99766	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2004.01.072
	CHEMBL288655	99766	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2004.01.072
	44289340	100764	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	664	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1F	10.1016/j.bmcl.2004.01.072
	CHEMBL296152	100764	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	664	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1F	10.1016/j.bmcl.2004.01.072
	44288911	167350	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	595	11	2	7	3.1	Cc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)n1C	10.1016/j.bmcl.2004.01.072
	CHEMBL43143	167350	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	595	11	2	7	3.1	Cc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)n1C	10.1016/j.bmcl.2004.01.072
	44400829	70958	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	412	9	1	4	6.4	CCN(CC)CCCC(C)Nc1nc(-c2ccc3ccccc3c2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195751	70958	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	412	9	1	4	6.4	CCN(CC)CCCC(C)Nc1nc(-c2ccc3ccccc3c2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	44400922	68293	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	11	1	5	4.6	CCN(CC)CCCC(C)Nc1ccnc(COc2cccc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL191915	68293	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	11	1	5	4.6	CCN(CC)CCCC(C)Nc1ccnc(COc2cccc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	44400881	71046	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(COc2cc(Cl)cc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195893	71046	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(COc2cc(Cl)cc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	45104427	199155	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	473	4	3	8	2.0	CC(=O)Nc1ccc(S(=O)(=O)N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)cc1	10.1021/jm901652p
	CHEMBL601217	199155	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	473	4	3	8	2.0	CC(=O)Nc1ccc(S(=O)(=O)N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)cc1	10.1021/jm901652p
	134325076	171609	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4473604	171609	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134211098	177460	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647117	177460	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	9856506	76390	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	260	2	1	3	4.8	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL206789	76390	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	260	2	1	3	4.8	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1C	10.1016/j.bmcl.2006.01.126
	44430305	86679	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ncn(CC)c12	10.1016/j.bmcl.2006.10.091
	CHEMBL232641	86679	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ncn(CC)c12	10.1016/j.bmcl.2006.10.091
	11223594	70725	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195298	70725	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44430315	11746	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL1182360	11746	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233047	11746	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	44430308	151581	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	433	10	1	5	5.7	CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL396787	151581	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	433	10	1	5	5.7	CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	44401007	70481	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195103	70481	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44289401	162881	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	604	10	2	6	4.0	O=C(CN1C(=O)[C@@H](CC(=O)N[C@@H]2CCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL41983	162881	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	604	10	2	6	4.0	O=C(CN1C(=O)[C@@H](CC(=O)N[C@@H]2CCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44289082	166008	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccco2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42799	166008	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccco2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	23585443	537	7	None	-	0	Dog	8.5	pIC50	=	8.5	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	537	7	None	-	0	Dog	8.5	pIC50	=	8.5	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	537	7	None	-	0	Dog	8.5	pIC50	=	8.5	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9900444	76793	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3ncccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207857	76793	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3ncccc23)n1	10.1016/j.bmcl.2006.01.126
	44406309	133000	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3ccnc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL370861	133000	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3ccnc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	692856	140819	16	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL383736	140819	16	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44288879	168766	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL44188	168766	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44400947	70963	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	396	11	1	5	4.9	CCN(CC)CCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195764	70963	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	396	11	1	5	4.9	CCN(CC)CCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	11496063	76751	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	CHEMBL207642	76751	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	44288903	165817	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	5	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42757	165817	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	5	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	45104849	200827	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	4	0	5	4.2	CCC1CCC(Oc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)CC1	10.1021/jm901652p
	CHEMBL611508	200827	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	4	0	5	4.2	CCC1CCC(Oc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)CC1	10.1021/jm901652p
	45104748	199342	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	3.5	Cc1cccc(N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)c1C	10.1021/jm901652p
	CHEMBL602474	199342	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	3.5	Cc1cccc(N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)c1C	10.1021/jm901652p
	44289098	100903	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	13	2	8	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL297173	100903	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	13	2	8	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1	10.1016/j.bmcl.2004.01.072
	134335394	171766	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	CHEMBL4475665	171766	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	134225255	176741	4	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	176741	4	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44289027	100749	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	652	8	1	5	6.3	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL296067	100749	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	652	8	1	5	6.3	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288779	100930	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	9	1	5	5.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL297335	100930	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	9	1	5	5.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289036	162544	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2cccs2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL417712	162544	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2cccs2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289106	164963	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	620	13	2	8	3.3	COc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(OC)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42411	164963	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	620	13	2	8	3.3	COc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(OC)c1	10.1016/j.bmcl.2004.01.072
	21866580	76778	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	481	8	1	3	8.0	Cc1cccc(Nc2cccc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)n2)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL207780	76778	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	481	8	1	3	8.0	Cc1cccc(Nc2cccc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)n2)c1C	10.1016/j.bmcl.2006.01.126
	44289276	167352	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	634	11	2	7	4.7	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1csc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43144	167352	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	634	11	2	7	4.7	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1csc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288726	168861	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	561	11	2	7	2.7	O=C(C[C@H]1S[C@H](c2ccncc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44262	168861	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	561	11	2	7	2.7	O=C(C[C@H]1S[C@H](c2ccncc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	71720517	86565	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	86565	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	44289235	100897	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	8	2	5	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL297145	100897	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	8	2	5	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289204	169271	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	614	10	2	6	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44401	169271	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	614	10	2	6	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134325003	174800	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4575089	174800	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134225259	177160	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4642563	177160	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44288904	164105	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	586	11	2	5	4.9	CN(C)CCCNC(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42168	164105	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	586	11	2	5	4.9	CN(C)CCCNC(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44289227	168857	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	600	11	1	5	5.2	CN(C)CCCN(C)C(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL44259	168857	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	600	11	1	5	5.2	CN(C)CCCN(C)C(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44430317	86900	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	439	12	3	7	4.8	CCN(CC)CCCC(C)Nc1nc(NC)nc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233261	86900	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	439	12	3	7	4.8	CCN(CC)CCCC(C)Nc1nc(NC)nc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	44288898	168112	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	515	8	1	4	5.4	CN(C)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL43661	168112	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	515	8	1	4	5.4	CN(C)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	155531126	171031	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4465359	171031	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	21866577	75597	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	285	2	1	4	4.7	Cn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	CHEMBL205279	75597	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	285	2	1	4	4.7	Cn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	134210898	177199	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643158	177199	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44411191	139696	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	484	8	1	4	7.4	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)nn2C)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL380537	139696	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	484	8	1	4	7.4	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)nn2C)c1C	10.1016/j.bmcl.2006.01.126
	156012782	176780	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637695	176780	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44289203	169956	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	12	2	6	5.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44498	169956	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	12	2	6	5.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134324973	169808	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4447900	169808	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	45104844	199226	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	1	6	1.6	COc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL601653	199226	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	1	6	1.6	COc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	134225255	176741	4	None	-	0	Mouse	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assayAntagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	176741	4	None	-	0	Mouse	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assayAntagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	71720517	86565	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	86565	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	134211057	177041	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641127	177041	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	44289341	162909	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	6	4.4	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL42001	162909	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	6	4.4	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44288923	163105	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)ccc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42046	163105	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)ccc1Cl	10.1016/j.bmcl.2004.01.072
	44288683	168493	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	578	11	2	6	3.5	O=C(C[C@H]1S[C@H](c2ccc(F)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43969	168493	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	578	11	2	6	3.5	O=C(C[C@H]1S[C@H](c2ccc(F)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	71449124	78568	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)c(Cl)c2)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113069	78568	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)c(Cl)c2)c1	10.1016/j.bmcl.2005.02.084
	134336138	176911	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639418	176911	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	45104752	199888	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	1	0	6	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc3c(cc12)OCO3	10.1021/jm901652p
	CHEMBL605581	199888	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	1	0	6	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc3c(cc12)OCO3	10.1021/jm901652p
	45104423	199225	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	330	2	2	6	1.3	C=CC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	CHEMBL601652	199225	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	330	2	2	6	1.3	C=CC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	45104321	199027	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	276	1	3	6	0.9	Cc1c(N2CCNCC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL600019	199027	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	276	1	3	6	0.9	Cc1c(N2CCNCC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	45104425	199185	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	2.5	Cc1c(N2CCN(C(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL601424	199185	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	2.5	Cc1c(N2CCN(C(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	134335394	171766	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	CHEMBL4475665	171766	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	44411266	76389	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	274	3	1	3	5.3	CC(C)c1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	CHEMBL206788	76389	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	274	3	1	3	5.3	CC(C)c1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	44289342	165548	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	606	11	2	6	4.1	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1C	10.1016/j.bmcl.2004.01.072
	CHEMBL42600	165548	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	606	11	2	6	4.1	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1C	10.1016/j.bmcl.2004.01.072
	156010350	176498	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633133	176498	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	10133595	76700	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	367	8	1	4	6.2	CC(C)CN(Cc1csc(Nc2cccc3ccccc23)n1)CC(C)C	10.1016/j.bmcl.2006.01.126
	CHEMBL207320	76700	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	367	8	1	4	6.2	CC(C)CN(Cc1csc(Nc2cccc3ccccc23)n1)CC(C)C	10.1016/j.bmcl.2006.01.126
	9899450	76171	2	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	232	2	1	3	4.2	CC(C)(C)c1csc(Nc2ccccc2)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL206103	76171	2	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	232	2	1	3	4.2	CC(C)(C)c1csc(Nc2ccccc2)n1	10.1016/j.bmcl.2006.01.126
	45104846	199068	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	301	2	0	5	1.9	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(N(C)C)ccc12	10.1021/jm901652p
	CHEMBL600409	199068	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	301	2	0	5	1.9	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(N(C)C)ccc12	10.1021/jm901652p
	45104845	197485	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	318	3	0	6	1.9	COc1cc(OC)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL589521	197485	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	318	3	0	6	1.9	COc1cc(OC)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	21866574	76722	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	271	2	2	3	4.7	CC(C)(C)c1csc(Nc2cccc3[nH]ccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207479	76722	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	271	2	2	3	4.7	CC(C)(C)c1csc(Nc2cccc3[nH]ccc23)n1	10.1016/j.bmcl.2006.01.126
	44430303	86678	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2[nH]cnc2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL232640	86678	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2[nH]cnc2n1	10.1016/j.bmcl.2006.10.091
	134225255	176741	4	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	176741	4	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	11525206	134692	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL372399	134692	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2006.10.091
	11525206	134692	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL372399	134692	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44430310	86817	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2ccccc2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233045	86817	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2ccccc2n1	10.1016/j.bmcl.2006.10.091
	3793	201510	70	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	201510	70	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	201510	70	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	3793	201510	70	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	201510	70	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	201510	70	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44562156	186137	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488704	186137	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	45104847	198742	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	2	0	5	1.9	COc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL598339	198742	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	2	0	5	1.9	COc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	156010372	176524	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4633494	176524	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	45104943	199429	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	5	0	6	3.5	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCc3cccs3)ccc12	10.1021/jm901652p
	CHEMBL603104	199429	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	5	0	6	3.5	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCc3cccs3)ccc12	10.1021/jm901652p
	45104524	199114	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	417	7	3	6	3.3	CCCCCCCNC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	CHEMBL600805	199114	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	417	7	3	6	3.3	CCCCCCCNC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	4015979	76979	2	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	302	3	1	3	5.7	c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	CHEMBL208452	76979	2	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	302	3	1	3	5.7	c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	134210768	176870	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4638846	176870	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44406246	72665	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	479	9	2	6	4.3	CC(C)[C@@H](CNc1nccc(OCc2ccc(Cl)cc2Cl)n1)NC(=O)C1CCCN(C)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL200966	72665	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	479	9	2	6	4.3	CC(C)[C@@H](CNc1nccc(OCc2ccc(Cl)cc2Cl)n1)NC(=O)C1CCCN(C)C1	10.1016/j.bmcl.2005.09.022
	44288897	101003	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	529	9	1	4	5.7	CN(C)CCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL297854	101003	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	529	9	1	4	5.7	CN(C)CCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44288663	99783	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	641	11	2	6	4.5	CN1CCN(CCCNC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	CHEMBL288800	99783	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	641	11	2	6	4.5	CN1CCN(CCCNC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	156010600	176554	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633920	176554	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	134325016	174071	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	CHEMBL4558456	174071	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	45104747	199320	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	370	2	2	6	3.0	Cc1c(N2CCN(c3ccc(F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL602269	199320	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	370	2	2	6	3.0	Cc1c(N2CCN(c3ccc(F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	134211225	177341	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4645325	177341	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44406338	72562	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	434	5	2	6	2.8	O=C([C@H]1CCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL200465	72562	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	434	5	2	6	2.8	O=C([C@H]1CCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44288972	165868	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	8	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42774	165868	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	8	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	45104525	199647	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	487	4	3	7	4.7	Cc1c(N2CCN(C(=O)Nc3ccccc3Oc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL604330	199647	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	487	4	3	7	4.7	Cc1c(N2CCN(C(=O)Nc3ccccc3Oc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	44289283	100771	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(CN1C(=O)[C@@H](CC(=O)NC(c2ccccc2)c2ccccc2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL296192	100771	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(CN1C(=O)[C@@H](CC(=O)NC(c2ccccc2)c2ccccc2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44289063	161410	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1-c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL415902	161410	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1-c1ccccc1	10.1016/j.bmcl.2004.01.072
	44289097	178039	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	680	11	2	6	5.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL46748	178039	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	680	11	2	6	5.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	45104426	200159	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	416	3	2	7	2.0	Cc1c(N2CCN(S(=O)(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL607137	200159	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	416	3	2	7	2.0	Cc1c(N2CCN(S(=O)(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	44401118	70711	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uMInhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uM	ChEMBL	388	10	1	4	5.7	CCN(CC)CCCC(C)Nc1nc(/C=C/c2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195203	70711	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uMInhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uM	ChEMBL	388	10	1	4	5.7	CCN(CC)CCCC(C)Nc1nc(/C=C/c2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	134324770	170366	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	CHEMBL4455432	170366	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	134225255	176741	4	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	176741	4	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44561217	188517	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL510375	188517	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44289057	164779	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2ccsc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42360	164779	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2ccsc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289281	100621	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	618	10	2	6	4.4	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL295057	100621	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	618	10	2	6	4.4	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	45104944	199024	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	387	5	0	7	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCOCC3)ccc12	10.1021/jm901652p
	CHEMBL600016	199024	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	387	5	0	7	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCOCC3)ccc12	10.1021/jm901652p
	44288799	101049	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL298230	101049	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	10417	1049	5	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	134324842	1049	5	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	CHEMBL4459231	1049	5	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	16724339	185845	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	185845	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	185845	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL487635	185845	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44406282	72344	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL199733	72344	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	44289055	99883	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	568	11	2	7	3.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccco1	10.1016/j.bmcl.2004.01.072
	CHEMBL289661	99883	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	568	11	2	7	3.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccco1	10.1016/j.bmcl.2004.01.072
	44288575	154631	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	10	2	6	3.6	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCCC2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL40238	154631	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	10	2	6	3.6	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCCC2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44288698	168516	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43988	168516	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134210954	177226	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643609	177226	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	3793	201510	70	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	201510	70	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	201510	70	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	25141190	1120	24	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	9478	1120	24	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	CHEMBL508207	1120	24	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	44561137	186127	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL488640	186127	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	45104850	199401	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	394	5	0	6	3.4	COc1ccc(COc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)cc1	10.1021/jm901652p
	CHEMBL602888	199401	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	394	5	0	6	3.4	COc1ccc(COc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)cc1	10.1021/jm901652p
	134211185	176569	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4634054	176569	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	156018849	177323	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4645037	177323	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	45104750	199223	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	274	1	1	5	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)ccc12	10.1021/jm901652p
	CHEMBL601650	199223	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	274	1	1	5	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)ccc12	10.1021/jm901652p
	44289343	165297	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42491	165297	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1Cl	10.1016/j.bmcl.2004.01.072
	3793	201510	70	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	201510	70	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	201510	70	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44430313	149257	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	485	5	2	7	3.3	O=C([C@@H]1CCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL394859	149257	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	485	5	2	7	3.3	O=C([C@@H]1CCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	44411037	76415	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	266	2	1	3	4.9	CC(C)(C)c1coc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL206878	76415	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	266	2	1	3	4.9	CC(C)(C)c1coc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	9814340	138966	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	282	2	1	3	5.3	CC(C)(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL379460	138966	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	282	2	1	3	5.3	CC(C)(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44410966	168465	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	311	6	1	4	4.9	CCN(CC)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL439518	168465	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	311	6	1	4	4.9	CCN(CC)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44406355	72404	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.0	O=C(C1CCCNC1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL199913	72404	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.0	O=C(C1CCCNC1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44288828	99979	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2c(Cl)cccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL290678	99979	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2c(Cl)cccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289242	154884	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40377	154884	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289205	162608	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	598	8	2	5	5.0	CN1CCC(NC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	CHEMBL418072	162608	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	598	8	2	5	5.0	CN1CCC(NC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	44288996	168783	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL44198	168783	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	44401087	70767	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CCN(CC)CCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195484	70767	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CCN(CC)CCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44430306	86780	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2ncn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL232839	86780	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2ncn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	44430307	86781	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2c(ncn2Cc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL232840	86781	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2c(ncn2Cc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	44288818	154861	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40366	154861	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288682	165520	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42585	165520	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	3117	206096	100	None	-4	16	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	206096	100	None	-4	16	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	45104424	199612	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	352	2	2	6	1.4	Cc1c(N2CCN(C(=O)CCl)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL604130	199612	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	352	2	2	6	1.4	Cc1c(N2CCN(C(=O)CCl)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	155541406	172416	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4518040	172416	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	5071677	75632	16	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	358	3	1	3	7.0	CC(C)(C)c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	CHEMBL205490	75632	16	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	358	3	1	3	7.0	CC(C)(C)c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	44411322	140371	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	CHEMBL382244	140371	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	44288481	100669	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	557	8	1	5	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL295405	100669	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	557	8	1	5	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288998	165936	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	10	3	5	4.3	NCCNC(=O)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42786	165936	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	10	3	5	4.3	NCCNC(=O)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44289278	167276	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)cc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43092	167276	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)cc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44401153	134746	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	368	9	1	5	4.1	CCN(CC)CCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL372670	134746	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	368	9	1	5	4.1	CCN(CC)CCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44288964	164341	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42226	164341	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1	10.1016/j.bmcl.2004.01.072
	134210933	176922	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639600	176922	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	71720517	86565	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	86565	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	127047356	139091	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	139091	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	59456102	73514	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2018964	73514	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	59455976	86713	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	CHEMBL2326611	86713	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	71583488	86718	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	CHEMBL2326616	86718	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	59455990	86735	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326632	86735	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	59456103	86725	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	CHEMBL2326622	86725	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	56849395	86748	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326926	86748	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59456014	86724	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	CHEMBL2326621	86724	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	11525206	134692	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL372399	134692	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	127045756	139326	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799266	139326	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	59455988	86723	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	CHEMBL2326620	86723	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	9959269	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	CHEMBL2018954	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	9959269	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL2018954	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	9959269	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	CHEMBL2018954	73503	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	59456050	86728	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	CHEMBL2326625	86728	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	118706830	112472	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310840	112472	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	59456019	86733	0	None	-	1	Human	5.5	pKd	=	5.5	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326630	86733	0	None	-	1	Human	5.5	pKd	=	5.5	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	9827294	73502	1	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	CHEMBL2018953	73502	1	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	9827294	73502	1	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	CHEMBL2018953	73502	1	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	59455975	86715	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326613	86715	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	59456010	86721	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	CHEMBL2326619	86721	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	118706817	112459	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310826	112459	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054387	86710	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326609	86710	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	58054475	86726	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326623	86726	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	10416	1841	23	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.ejmech.2016.02.058
	46861584	1841	23	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.ejmech.2016.02.058
	CHEMBL2018969	1841	23	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.ejmech.2016.02.058
	10416	1841	23	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	46861584	1841	23	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	CHEMBL2018969	1841	23	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	59456026	86734	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326631	86734	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59456058	86736	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326633	86736	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	118706831	112473	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310841	112473	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054384	86709	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	CHEMBL2326608	86709	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	58054368	86727	0	None	-	1	Human	7.1	pKd	=	7.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326624	86727	0	None	-	1	Human	7.1	pKd	=	7.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	102143549	112471	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310839	112471	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	136116031	86361	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	CHEMBL2321924	86361	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	59456111	86720	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	CHEMBL2326618	86720	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	59456012	86717	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326615	86717	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	9827294	73502	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018953	73502	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	127047356	139091	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	139091	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	127045756	139326	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799266	139326	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	71462571	82144	1	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to CCR4Binding affinity to CCR4	ChEMBL	506	8	3	8	3.5	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(NC(=O)CO)c1	10.1021/jm300682j
	CHEMBL2178575	82144	1	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to CCR4Binding affinity to CCR4	ChEMBL	506	8	3	8	3.5	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(NC(=O)CO)c1	10.1021/jm300682j
	10416	1841	23	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	46861584	1841	23	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	CHEMBL2018969	1841	23	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	127047973	139222	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	496	5	1	6	4.9	O=C(c1ccccn1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798539	139222	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	496	5	1	6	4.9	O=C(c1ccccn1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127045977	139440	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799904	139440	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59455974	73511	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018961	73511	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	16747697	93082	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246334	93082	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	71457815	83557	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	3.8	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207091	83557	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	3.8	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	71214976	83568	0	None	-79	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.5	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207101	83568	0	None	-79	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.5	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	44440045	93146	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	443	6	1	4	3.2	CC(C)CN1CCC(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246584	93146	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	443	6	1	4	3.2	CC(C)CN1CCC(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.03.030
	44440043	166303	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	469	7	1	4	3.7	CC(C)c1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2007.03.030
	CHEMBL428576	166303	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	469	7	1	4	3.7	CC(C)c1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2007.03.030
	176	394	63	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	394	63	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	394	63	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	394	63	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	394	63	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	59456102	73514	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018964	73514	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	127046413	139573	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	462	6	2	6	3.4	CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797946	139573	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	462	6	2	6	3.4	CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3800702	139573	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	462	6	2	6	3.4	CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59455992	73506	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018957	73506	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	71461439	83553	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207087	83553	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.020
	71452487	83554	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207088	83554	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1	10.1016/j.bmcl.2012.09.020
	58054487	73513	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018963	73513	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	44440051	149071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL394714	149071	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	127045976	139288	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799025	139288	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59456051	73517	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018967	73517	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	16747697	93082	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assayDisplacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246334	93082	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assayDisplacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	44440041	93090	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	441	7	1	4	2.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)Cc1ccccc1	10.1016/j.bmcl.2007.03.030
	CHEMBL246384	93090	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	441	7	1	4	2.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)Cc1ccccc1	10.1016/j.bmcl.2007.03.030
	71450658	83564	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.7	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207098	83564	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.7	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	59455973	73505	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccccc1Cn1nc(NS(=O)(=O)c2ccc(Cl)s2)c2c(OC)cccc21	10.1016/j.bmcl.2012.02.104
	CHEMBL2018956	73505	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccccc1Cn1nc(NS(=O)(=O)c2ccc(Cl)s2)c2c(OC)cccc21	10.1016/j.bmcl.2012.02.104
	58054491	73516	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(C)=O)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018966	73516	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(C)=O)cc1	10.1016/j.bmcl.2012.02.104
	127046189	139078	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797567	139078	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	58054516	73508	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	CHEMBL2018959	73508	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	15604497	83565	0	None	-79	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	432	5	1	7	3.0	Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207099	83565	0	None	-79	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	432	5	1	7	3.0	Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	11525206	134692	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL372399	134692	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	127046247	139073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	2	6	4.8	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797537	139073	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	2	6	4.8	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	44440135	92890	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	CHEMBL245319	92890	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	44440081	92952	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	582	8	1	5	3.9	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(N)=O)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245730	92952	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	582	8	1	5	3.9	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(N)=O)CC1	10.1016/j.bmcl.2007.03.030
	127045978	139139	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797980	139139	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127045975	139187	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798263	139187	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127046787	139373	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	1	6	4.0	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(C(=O)C4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799514	139373	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	1	6	4.0	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(C(=O)C4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	127046613	139430	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	456	5	2	6	2.9	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(F)cc4F)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799865	139430	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	456	5	2	6	2.9	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(F)cc4F)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	44440031	148959	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	427	6	1	3	4.6	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	CHEMBL394642	148959	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	427	6	1	3	4.6	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	70689680	73504	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018955	73504	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	59456072	73507	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018958	73507	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1	10.1016/j.bmcl.2012.02.104
	70681287	73510	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	CHEMBL2018960	73510	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	71461438	83548	0	None	-251	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207082	83548	0	None	-251	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	71461440	83563	0	None	-79	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	400	5	1	5	3.6	O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207097	83563	0	None	-79	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	400	5	1	5	3.6	O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	44440072	93083	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	557	7	0	4	5.0	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2F)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246335	93083	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	557	7	0	4	5.0	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2F)CC1	10.1016/j.bmcl.2007.03.030
	44440047	93147	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1cccc2ccccc12)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246585	93147	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1cccc2ccccc12)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	44440083	150266	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	554	7	1	5	4.4	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2N)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL395680	150266	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	554	7	1	5	4.4	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2N)CC1	10.1016/j.bmcl.2007.03.030
	44440059	93078	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	553	8	0	4	5.2	CCN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246328	93078	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	553	8	0	4	5.2	CCN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	9959269	73503	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	CHEMBL2018954	73503	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	127046614	139383	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799578	139383	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	9959269	73503	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	CHEMBL2018954	73503	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	127046612	139207	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798452	139207	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127046412	139571	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	391	4	2	5	4.0	Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797678	139571	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	391	4	2	5	4.0	Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3800700	139571	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	391	4	2	5	4.0	Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	58054532	73512	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018962	73512	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	71456007	83558	0	None	-1	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	373	5	1	6	2.7	N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207092	83558	0	None	-1	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	373	5	1	6	2.7	N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1	10.1016/j.bmcl.2012.09.020
	71456008	83561	0	None	-50	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	404	5	1	6	4.0	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12	10.1016/j.bmcl.2012.09.020
	CHEMBL2207095	83561	0	None	-50	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	404	5	1	6	4.0	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12	10.1016/j.bmcl.2012.09.020
	70685473	73500	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018951	73500	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	59456003	73501	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018952	73501	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	15985912	83547	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207081	83547	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	71450657	83560	0	None	-15	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207094	83560	0	None	-15	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1	10.1016/j.bmcl.2012.09.020
	71452488	83559	0	None	-79	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	388	5	1	6	3.5	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207093	83559	0	None	-79	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	388	5	1	6	3.5	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	44440076	150862	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2cccc(Cl)c2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL396166	150862	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2cccc(Cl)c2)CC1	10.1016/j.bmcl.2007.03.030
	44440084	92991	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	607	7	0	4	5.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(F)(F)F)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245931	92991	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	607	7	0	4	5.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(F)(F)F)CC1	10.1016/j.bmcl.2007.03.030
	3117	206096	100	None	-4	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	206096	100	None	-4	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	44440075	92892	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2Cl)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245331	92892	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2Cl)CC1	10.1016/j.bmcl.2007.03.030
	44440028	93432	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	CHEMBL247976	93432	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	44440079	92919	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	569	8	0	5	4.8	COc1cccc(CCN2CCC(N(C)C(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc4c(Cl)cccc4c3)CC2)c1	10.1016/j.bmcl.2007.03.030
	CHEMBL245531	92919	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	569	8	0	5	4.8	COc1cccc(CCN2CCC(N(C)C(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc4c(Cl)cccc4c3)CC2)c1	10.1016/j.bmcl.2007.03.030
	127047612	139349	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799393	139349	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127047970	139279	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.2	O=C(C1CCCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798949	139279	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.2	O=C(C1CCCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127046191	139572	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	3.8	O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798941	139572	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	3.8	O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3800701	139572	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	3.8	O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	70693879	73059	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2016602	73059	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	16747697	93082	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246334	93082	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	71454246	83555	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	376	5	1	5	3.4	Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C	10.1016/j.bmcl.2012.09.020
	CHEMBL2207089	83555	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	376	5	1	5	3.4	Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C	10.1016/j.bmcl.2012.09.020
	71454248	83567	0	None	-39	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207100	83567	0	None	-39	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	44440080	152813	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	583	8	1	5	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(=O)O)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL397848	152813	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	583	8	1	5	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(=O)O)CC1	10.1016/j.bmcl.2007.03.030
	44440054	93249	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	505	7	0	4	4.2	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246986	93249	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	505	7	0	4	4.2	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	44440055	152807	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	519	8	0	4	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL397845	152807	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	519	8	0	4	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	71214725	83549	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207083	83549	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	71214710	83551	0	None	-39	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	431	5	1	6	3.6	Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207085	83551	0	None	-39	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	431	5	1	6	3.6	Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	127047972	139077	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	501	5	1	5	5.8	O=C(C1CCCCC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797555	139077	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	501	5	1	5	5.8	O=C(C1CCCCC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59456067	73518	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018968	73518	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	44440077	92893	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245332	92893	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2007.03.030
	44440065	92889	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	523	7	0	4	4.3	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(F)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245313	92889	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	523	7	0	4	4.3	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(F)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	10416	1841	23	None	-	1	Human	7.8	pIC50	=	7.8	Binding	IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.	Guide to Pharmacology	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	23409871
	46861584	1841	23	None	-	1	Human	7.8	pIC50	=	7.8	Binding	IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.	Guide to Pharmacology	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	23409871
	CHEMBL2018969	1841	23	None	-	1	Human	7.8	pIC50	=	7.8	Binding	IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.	Guide to Pharmacology	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	23409871
	176	394	63	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	394	63	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	394	63	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	394	63	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	394	63	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	3117	206096	100	None	-4	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	CHEMBL964	206096	100	None	-4	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None

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Ligand source activities (1 row/activity)