Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
156013177 176873 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638895 176873 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156011084 176511 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633217 176511 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021011 177467 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647206 177467 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768224 177382 14 None 39 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645971 177382 14 None 39 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015010 176966 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640319 176966 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012910 176862 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638791 176862 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019927 177365 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 10.1016/j.bmcl.2019.126899
CHEMBL4645725 177365 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 10.1016/j.bmcl.2019.126899
156019169 177423 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4646463 177423 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156016038 177043 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641144 177043 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013415 176889 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639114 176889 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020735 177532 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648121 177532 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021922 177607 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4649351 177607 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010556 176450 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632425 176450 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010734 176504 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633183 176504 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
25303824 177541 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648327 177541 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016810 177167 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642662 177167 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016430 177088 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641681 177088 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019204 177370 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645763 177370 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018695 177284 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644405 177284 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016371 177056 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641301 177056 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
25303824 176812 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638193 176812 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020287 177501 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647701 177501 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014652 176650 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4635707 176650 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012554 176762 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637473 176762 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012971 176929 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639692 176929 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012542 176740 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 176740 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014926 176963 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
CHEMBL4640301 176963 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
156017591 177258 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 455 5 2 5 3.8 O=C(CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1ccc3c(c1)OCO3)C2)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2019.126899
CHEMBL4644085 177258 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 455 5 2 5 3.8 O=C(CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1ccc3c(c1)OCO3)C2)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2019.126899
156019124 177346 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1ccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2019.126899
CHEMBL4645432 177346 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1ccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2019.126899
156018089 177265 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644133 177265 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018738 177342 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4645361 177342 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156019654 177429 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646569 177429 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010068 176487 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632989 176487 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015077 176943 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639996 176943 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156017102 177128 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642230 177128 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015991 176948 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640101 176948 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012383 176833 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638493 176833 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015439 176972 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640388 176972 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019227 177400 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646120 177400 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020329 177573 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648997 177573 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014947 177004 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640657 177004 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
156019475 177395 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 464 7 2 6 3.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646034 177395 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 464 7 2 6 3.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010556 176450 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632425 176450 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020287 177501 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647701 177501 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020779 177596 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 509 8 1 8 4.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4649243 177596 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 509 8 1 8 4.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019227 177400 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646120 177400 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019654 177429 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646569 177429 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768224 177382 14 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645971 177382 14 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012910 176862 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638791 176862 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015439 176972 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640388 176972 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020329 177573 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648997 177573 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018738 177342 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4645361 177342 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156016430 177088 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641681 177088 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020735 177532 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648121 177532 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768224 177382 14 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645971 177382 14 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768225 177279 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 10.1016/j.bmcl.2019.126899
CHEMBL4644339 177279 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 10.1016/j.bmcl.2019.126899
156019169 177423 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4646463 177423 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156012542 176740 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 176740 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014218 176659 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 463 7 2 5 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4635792 176659 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 463 7 2 5 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018695 177284 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644405 177284 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012971 176929 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639692 176929 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012383 176833 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638493 176833 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015010 176966 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640319 176966 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156017102 177128 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642230 177128 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021011 177467 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647206 177467 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013810 176699 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 511 8 1 8 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(OC)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4636339 176699 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 511 8 1 8 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(OC)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012554 176762 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637473 176762 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019204 177370 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645763 177370 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021922 177607 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4649351 177607 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013800 176694 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2c(Cl)cccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4636310 176694 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2c(Cl)cccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012542 176740 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 176740 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012542 176740 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 176740 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014652 176650 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4635707 176650 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014926 176963 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
CHEMBL4640301 176963 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
156016810 177167 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642662 177167 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
25303824 177541 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648327 177541 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013415 176889 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639114 176889 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018089 177265 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644133 177265 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015077 176943 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639996 176943 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016371 177056 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641301 177056 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156011084 176511 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633217 176511 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016540 177153 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 465 7 1 7 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3o2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642449 177153 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 465 7 1 7 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3o2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014947 177004 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640657 177004 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013177 176873 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638895 176873 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015991 176948 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640101 176948 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010734 176504 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633183 176504 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010068 176487 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632989 176487 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016038 177043 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641144 177043 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021218 177558 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(C)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648749 177558 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(C)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
855 1220 0 None - 1 Human 9.0 pKd = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11290797