GPCRdb

Ligand source activities (1 row/activity)

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	5803	390	15	None	-2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	854189	390	15	None	-2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	CHEMBL594671	390	15	None	-2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	46235794	162373	0	None	2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4174307	162373	0	None	2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	67209751	161608	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4162307	161608	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898644	162535	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4177037	162535	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	145953626	161949	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167577	161949	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145953603	161918	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167161	161918	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145953670	162000	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168456	162000	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	162666399	181793	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	468	6	2	4	3.8	CC(Oc1cccc(Cl)c1)C(=O)N(C)[C@H]1CC[C@]2(CC1)NC(=N)N(Cc1ccccc1)C2=O	10.1016/j.bmcl.2020.127460
	CHEMBL4785193	181793	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	468	6	2	4	3.8	CC(Oc1cccc(Cl)c1)C(=O)N(C)[C@H]1CC[C@]2(CC1)NC(=N)N(Cc1ccccc1)C2=O	10.1016/j.bmcl.2020.127460
	57520598	1774	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	8417	1774	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	CHEMBL3353541	1774	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	DB15406	1774	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	145951537	162147	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4170829	162147	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	53302677	162285	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4172928	162285	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67258265	162166	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171128	162166	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145957026	161647	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4162808	161647	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	117898634	161833	0	None	-5	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4165748	161833	0	None	-5	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	145971768	162559	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4177359	162559	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145971768	162559	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4177359	162559	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145954653	162076	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169673	162076	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	53302677	162285	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmcl.2020.127460
	CHEMBL4172928	162285	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmcl.2020.127460
	145951076	162411	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175033	162411	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145954653	162076	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169673	162076	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	145953670	162000	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168456	162000	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	5803	390	15	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	854189	390	15	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	CHEMBL594671	390	15	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	67210172	161896	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4166818	161896	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67209218	162318	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4173387	162318	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	67209297	162236	0	None	-7	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4172349	162236	0	None	-7	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145952068	162301	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4173130	162301	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145950070	162204	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171813	162204	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145949561	162378	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4174384	162378	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	145954073	161931	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167352	161931	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	67209297	162236	0	None	7	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4172349	162236	0	None	7	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	53302677	162285	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1021/acs.jmedchem.8b00855
	CHEMBL4172928	162285	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1021/acs.jmedchem.8b00855
	145955080	162068	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169498	162068	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145952174	162436	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175443	162436	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145954381	162013	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	530	6	1	5	6.9	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2c(-c3ccccc3)noc2C2CC2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168646	162013	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	530	6	1	5	6.9	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2c(-c3ccccc3)noc2C2CC2)cc1	10.1021/acs.jmedchem.8b00855
	145962491	161809	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4165226	161809	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145949561	162378	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4174384	162378	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	145956912	161491	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4160351	161491	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145952068	162301	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4173130	162301	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145959365	161439	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159447	161439	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	145951076	162411	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175033	162411	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145951986	162142	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4170748	162142	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	67209751	161608	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4162307	161608	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898634	161833	0	None	5	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4165748	161833	0	None	5	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898651	162331	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4173663	162331	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	117898644	162535	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4177037	162535	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	1032	3124	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	1062	3124	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	CHEMBL14021	3124	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	DB03766	3124	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	46235794	162373	0	None	-2	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4174307	162373	0	None	-2	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145951986	162142	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4170748	162142	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145952606	162438	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175455	162438	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	145954073	161931	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167352	161931	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145957346	161409	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159019	161409	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	67210172	161896	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4166818	161896	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67209218	162318	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4173387	162318	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145949794	162155	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4170872	162155	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145953603	161918	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167161	161918	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145959365	161439	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159447	161439	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	145958427	161543	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	4	1	6	3.7	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4161202	161543	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	4	1	6	3.7	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	138319694	162512	23	None	-5	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162512	23	None	-5	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145951370	162219	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171999	162219	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145952606	162438	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175455	162438	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	5803	390	15	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1021/acs.jmedchem.8b00855
	854189	390	15	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1021/acs.jmedchem.8b00855
	CHEMBL594671	390	15	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1021/acs.jmedchem.8b00855
	145951370	162219	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171999	162219	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145956912	161491	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4160351	161491	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145959580	161775	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	CHEMBL4164813	161775	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	145949591	162159	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	CHEMBL4170955	162159	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	145951537	162147	0	None	-3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4170829	162147	0	None	-3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	53302677	162285	0	None	-1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4172928	162285	0	None	-1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	138319694	162512	23	None	-5	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol productionAgonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162512	23	None	-5	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol productionAgonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	67258265	162166	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171128	162166	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145952174	162436	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175443	162436	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145957026	161647	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4162808	161647	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	145958672	161555	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4161397	161555	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	138319694	162512	23	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162512	23	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	117898651	162331	0	None	-3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4173663	162331	0	None	-3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	145949794	162155	0	None	-2	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4170872	162155	0	None	-2	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	138319694	162512	23	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162512	23	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	162648013	179382	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	427	8	1	4	6.3	Cc1nc(-c2ccccc2Cl)sc1COc1cccc([C@@H](CC(=O)O)C2CC2)c1	10.1016/j.bmcl.2020.127460
	CHEMBL4746807	179382	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	427	8	1	4	6.3	Cc1nc(-c2ccccc2Cl)sc1COc1cccc([C@@H](CC(=O)O)C2CC2)c1	10.1016/j.bmcl.2020.127460
	145955080	162068	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169498	162068	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145953626	161949	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167577	161949	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145950070	162204	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171813	162204	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145958672	161555	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4161397	161555	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145949591	162159	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	CHEMBL4170955	162159	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	145959580	161775	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	CHEMBL4164813	161775	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	145957346	161409	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159019	161409	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145962491	161809	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4165226	161809	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	46226274	200625	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	342	3	1	3	5.2	CC(C)(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610333	200625	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	342	3	1	3	5.2	CC(C)(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	118719384	115012	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	384	5	1	2	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)NCc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3352999	115012	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	384	5	1	2	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)NCc2ccc(Cl)cc2)c1	10.1021/jm5012885
	68175794	115017	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	427	7	1	3	3.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCN)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353004	115017	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	427	7	1	3	3.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCN)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	118719385	115018	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	2	3	3.4	CNC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353005	115018	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	2	3	3.4	CNC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	46226177	198077	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	279	4	2	4	2.2	CC(C)C(C(=O)Nc1nnn[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593826	198077	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	279	4	2	4	2.2	CC(C)C(C(=O)Nc1nnn[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226178	198078	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1cc[nH]n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593827	198078	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1cc[nH]n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	847243	198226	11	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	252	3	1	3	3.0	O=C(Cc1ccc(Cl)cc1)Nc1nccs1	10.1016/j.bmcl.2009.11.112
	CHEMBL594760	198226	11	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	252	3	1	3	3.0	O=C(Cc1ccc(Cl)cc1)Nc1nccs1	10.1016/j.bmcl.2009.11.112
	46226356	198220	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	292	5	1	3	4.1	C=CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594738	198220	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	292	5	1	3	4.1	C=CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226144	198223	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1cccc(F)n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594746	198223	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1cccc(F)n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226383	200373	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	4.4	O=C(Nc1ncc(F)s1)[C@H](c1ccc(C(F)(F)F)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL608697	200373	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	4.4	O=C(Nc1ncc(F)s1)[C@H](c1ccc(C(F)(F)F)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	46226106	198428	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	225	3	1	1	2.8	CNC(=O)[C@H](c1ccc(Cl)cc1)C(C)C	10.1016/j.bmcl.2009.11.112
	CHEMBL596153	198428	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	225	3	1	1	2.8	CNC(=O)[C@H](c1ccc(Cl)cc1)C(C)C	10.1016/j.bmcl.2009.11.112
	77904272	115118	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)CCc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353510	115118	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)CCc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70558275	115124	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353516	115124	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	89894240	115145	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	1	5	4.6	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353539	115145	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	1	5	4.6	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	70559113	115116	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353502	115116	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226336	198263	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	4	1	3	4.1	O=C(Nc1ncc(F)s1)[C@H](c1ccc(Cl)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594998	198263	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	4	1	3	4.1	O=C(Nc1ncc(F)s1)[C@H](c1ccc(Cl)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	46226312	200050	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	474	4	2	4	5.9	CC(C)(C)[C@H](C(=O)Nc1ncc(C(O)(C(F)(F)F)C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL606629	200050	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	474	4	2	4	5.9	CC(C)(C)[C@H](C(=O)Nc1ncc(C(O)(C(F)(F)F)C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	29369661	198190	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1nncs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594537	198190	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1nncs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	68176091	115084	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	8	0	3	4.2	COCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353464	115084	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	8	0	3	4.2	COCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	70556816	115088	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	441	7	1	3	3.0	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353468	115088	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	441	7	1	3	3.0	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	70561343	115125	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	2	5	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353517	115125	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	2	5	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226145	200498	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1ccc(F)cn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609584	200498	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1ccc(F)cn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70561241	115146	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	2	5	3.7	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353540	115146	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	2	5	3.7	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	46226143	198222	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594745	198222	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	9095896	198373	2	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1csc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)n1	10.1016/j.bmcl.2009.11.112
	CHEMBL595715	198373	2	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1csc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)n1	10.1016/j.bmcl.2009.11.112
	68175951	115113	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	4	0	3	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353498	115113	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	4	0	3	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	89900352	115086	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	479	8	0	4	5.4	CC1(C(=O)N(CCCC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353466	115086	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	479	8	0	4	5.4	CC1(C(=O)N(CCCC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	89900321	115013	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	398	5	0	2	4.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353000	115013	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	398	5	0	2	4.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	70556487	115011	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	5	1	3	4.4	CC1(C(=O)NCc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3352998	115011	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	5	1	3	4.4	CC1(C(=O)NCc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226360	200464	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	4.0	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCC1	10.1016/j.bmcl.2009.11.112
	CHEMBL609291	200464	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	4.0	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCC1	10.1016/j.bmcl.2009.11.112
	46226254	200536	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609861	200536	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226290	200537	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	333	3	1	4	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609863	200537	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	333	3	1	4	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226291	200800	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	376	3	1	3	5.6	CC(C)(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611340	200800	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	376	3	1	3	5.6	CC(C)(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70565254	115135	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	2	4	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)c1	10.1021/jm5012885
	CHEMBL3353528	115135	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	2	4	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)c1	10.1021/jm5012885
	68176356	115091	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	9	1	3	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353471	115091	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	9	1	3	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	68176096	115090	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	7	0	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N(C)C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353470	115090	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	7	0	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N(C)C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	46226308	198219	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	351	4	1	4	4.6	CN(C)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594737	198219	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	351	4	1	4	4.6	CN(C)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	46226309	199594	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	393	4	1	5	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCOCC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL604059	199594	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	393	4	1	5	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCOCC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226385	198303	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	311	4	1	4	3.5	O=C(Nc1ncc(F)s1)[C@H](c1ccnc(Cl)c1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL595235	198303	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	311	4	1	4	3.5	O=C(Nc1ncc(F)s1)[C@H](c1ccnc(Cl)c1)C1CC1	10.1016/j.bmcl.2009.11.112
	89894379	132927	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	482	9	1	4	4.5	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3706688	132927	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	482	9	1	4	4.5	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	46226235	200428	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1nc(C(F)(F)F)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL608991	200428	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1nc(C(F)(F)F)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70556496	115130	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353523	115130	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	46226251	200701	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	322	4	1	3	4.8	Cc1nc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)sc1C	10.1016/j.bmcl.2009.11.112
	CHEMBL610741	200701	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	322	4	1	3	4.8	Cc1nc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)sc1C	10.1016/j.bmcl.2009.11.112
	36477073	198232	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	363	4	1	4	4.6	CC(C)[C@H](C(=O)Nc1nnc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594770	198232	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	363	4	1	4	4.6	CC(C)[C@H](C(=O)Nc1nnc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226255	198083	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	319	4	1	4	4.0	CC(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593839	198083	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	319	4	1	4	4.0	CC(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	39725404	198176	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	352	5	1	5	4.0	COC(=O)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594505	198176	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	352	5	1	5	4.0	COC(=O)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	46226163	198233	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1ncns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594771	198233	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1ncns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	135971436	197990	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	2.8	CC(C)[C@H](C(=O)NC1=NC(=O)CS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593121	197990	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	2.8	CC(C)[C@H](C(=O)NC1=NC(=O)CS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226164	198058	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1ncc[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593607	198058	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1ncc[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	2520490	197989	2	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	296	3	1	3	3.3	CC(C)[C@H](C(=O)NC1=NCCS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593120	197989	2	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	296	3	1	3	3.3	CC(C)[C@H](C(=O)NC1=NCCS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89894269	132928	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	454	7	1	4	3.7	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3706689	132928	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	454	7	1	4	3.7	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	46226161	198029	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)[C@H](C(=O)Nc1cccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593435	198029	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)[C@H](C(=O)Nc1cccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226311	198178	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	441	4	1	6	3.8	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCS(=O)(=O)CC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594507	198178	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	441	4	1	6	3.8	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCS(=O)(=O)CC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	68176357	115098	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353478	115098	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	89900347	115085	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	451	6	0	4	4.6	CC1(C(=O)N(CC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353465	115085	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	451	6	0	4	4.6	CC1(C(=O)N(CC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70559604	115122	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353514	115122	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226162	198030	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ncco1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593436	198030	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ncco1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226295	198115	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	432	5	1	3	6.8	CC(C)(C)[C@H](C(=O)Nc1ncc(Cc2ccc(Cl)cc2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594074	198115	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	432	5	1	3	6.8	CC(C)(C)[C@H](C(=O)Nc1ncc(Cc2ccc(Cl)cc2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559551	115121	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	518	8	1	4	5.4	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353513	115121	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	518	8	1	4	5.4	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	89894353	115143	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	516	9	1	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353536	115143	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	516	9	1	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	89900371	115102	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	519	10	1	4	3.5	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353481	115102	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	519	10	1	4	3.5	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	89900327	115014	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353001	115014	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70558376	115103	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	7	1	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353482	115103	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	7	1	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	88757504	115129	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)nc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353522	115129	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)nc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226182	200535	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	5.3	CC(C)C(C(=O)Nc1nc2ccccc2s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609852	200535	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	5.3	CC(C)C(C(=O)Nc1nc2ccccc2s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70558485	115105	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	4.6	CC1(C(=O)N(CCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353484	115105	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	4.6	CC1(C(=O)N(CCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70557254	115126	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	507	8	1	6	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353518	115126	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	507	8	1	6	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	118719612	115000	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	4	4.3	COc1c(C(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)csc1Cl	10.1021/jm5012885
	CHEMBL3352828	115000	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	4	4.3	COc1c(C(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)csc1Cl	10.1021/jm5012885
	68176101	115016	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	456	7	1	4	4.1	CC1(C(=O)N(CCO)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353003	115016	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	456	7	1	4	4.1	CC1(C(=O)N(CCO)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	118719611	115110	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	4	0	2	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cccc2ccccc12	10.1021/jm5012885
	CHEMBL3353491	115110	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	4	0	2	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cccc2ccccc12	10.1021/jm5012885
	118719617	115114	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	4	0	3	5.5	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccc(Cl)cc12	10.1021/jm5012885
	CHEMBL3353499	115114	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	4	0	3	5.5	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccc(Cl)cc12	10.1021/jm5012885
	70557757	115132	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)c1	10.1021/jm5012885
	CHEMBL3353525	115132	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)c1	10.1021/jm5012885
	118719609	115096	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	497	8	1	4	4.3	CC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353476	115096	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	497	8	1	4	4.3	CC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226293	200499	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	4	1	5	4.0	CC(C)(C)[C@H](C(=O)Nc1ncc(S(C)(=O)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609586	200499	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	4	1	5	4.0	CC(C)(C)[C@H](C(=O)Nc1ncc(S(C)(=O)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70556905	115120	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353512	115120	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70556713	115104	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	4.2	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353483	115104	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	4.2	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70559086	115140	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353533	115140	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226179	200337	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ccon1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL608384	200337	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ccon1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559096	115087	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	9	0	4	4.5	COC(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353467	115087	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	9	0	4	4.5	COC(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	46226310	198177	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	406	4	1	5	4.3	CN1CCN(c2cnc(NC(=O)[C@H](c3ccc(Cl)cc3)C(C)(C)C)s2)CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594506	198177	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	406	4	1	5	4.3	CN1CCN(c2cnc(NC(=O)[C@H](c3ccc(Cl)cc3)C(C)(C)C)s2)CC1	10.1016/j.bmcl.2009.11.112
	89900361	115094	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	539	9	0	4	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353474	115094	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	539	9	0	4	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	70562777	115141	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	2	5	4.2	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353534	115141	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	2	5	4.2	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70557843	115106	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353485	115106	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	68175817	115097	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCNS(C)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353477	115097	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCNS(C)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	46226234	200700	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc2cc(Cl)ccc2o1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610740	200700	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc2cc(Cl)ccc2o1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89901463	115101	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	547	10	1	5	4.1	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353480	115101	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	547	10	1	5	4.1	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	68176095	115089	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	3	3.3	CNC(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353469	115089	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	3	3.3	CNC(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	89900348	115111	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	423	5	0	3	4.0	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cn(C)c2ccccc12	10.1021/jm5012885
	CHEMBL3353492	115111	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	423	5	0	3	4.0	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cn(C)c2ccccc12	10.1021/jm5012885
	46226386	198184	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	1	4	2.8	O=C(Nc1ncc(F)s1)[C@H](c1ccccn1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594528	198184	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	1	4	2.8	O=C(Nc1ncc(F)s1)[C@H](c1ccccn1)C1CC1	10.1016/j.bmcl.2009.11.112
	46226333	198227	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	266	3	1	3	3.5	C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594761	198227	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	266	3	1	3	3.5	C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89900346	115093	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	511	7	0	4	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353473	115093	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	511	7	0	4	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	68176013	115015	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	6	0	2	4.5	CCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353002	115015	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	6	0	2	4.5	CCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	70564780	115139	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	503	9	2	4	4.8	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353532	115139	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	503	9	2	4	4.8	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226142	198221	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)C(C(=O)Nc1cccnc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594744	198221	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)C(C(=O)Nc1cccnc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	3420	3379	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	46226252	3379	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	CHEMBL594525	3379	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	46226292	198225	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	354	4	1	4	5.3	CSc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594758	198225	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	354	4	1	4	5.3	CSc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	70557810	115138	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353531	115138	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226361	198257	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	324	3	1	3	4.4	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594974	198257	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	324	3	1	3	4.4	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCC1	10.1016/j.bmcl.2009.11.112
	46226334	200538	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	280	4	1	3	3.9	CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609870	200538	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	280	4	1	3	3.9	CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226358	200892	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	298	3	1	3	3.9	CC(C)(C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611948	200892	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	298	3	1	3	3.9	CC(C)(C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89900356	115115	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc2ccccc2s1	10.1021/jm5012885
	CHEMBL3353500	115115	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc2ccccc2s1	10.1021/jm5012885
	70556743	115117	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	5	3.1	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1noc2ccccc12	10.1021/jm5012885
	CHEMBL3353505	115117	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	5	3.1	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1noc2ccccc12	10.1021/jm5012885
	70558482	115112	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	396	4	0	3	4.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1ccc2occc2c1	10.1021/jm5012885
	CHEMBL3353495	115112	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	396	4	0	3	4.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1ccc2occc2c1	10.1021/jm5012885
	68176100	115092	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	8	1	3	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353472	115092	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	8	1	3	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	4964042	200579	5	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	327	4	2	2	4.6	CC(C)C(C(=O)Nc1nc2ccccc2[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610060	200579	5	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	327	4	2	2	4.6	CC(C)C(C(=O)Nc1nc2ccccc2[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226146	198020	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1ncccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593351	198020	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1ncccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226335	198228	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	5	1	3	4.3	CCC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594762	198228	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	5	1	3	4.3	CCC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559021	115131	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	3	4.7	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)c1	10.1021/jm5012885
	CHEMBL3353524	115131	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	3	4.7	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)c1	10.1021/jm5012885
	25479840	198027	1	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccncc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593433	198027	1	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccncc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70557930	115137	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	532	9	1	4	5.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353530	115137	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	532	9	1	4	5.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226160	200847	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1cnccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611632	200847	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1cnccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226180	198488	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1cnns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL596580	198488	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1cnns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559585	115127	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2cc(Cl)ccn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353520	115127	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2cc(Cl)ccn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	118719610	115109	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	452	6	0	3	5.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccsc2)c1	10.1021/jm5012885
	CHEMBL3353490	115109	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	452	6	0	3	5.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccsc2)c1	10.1021/jm5012885
	46226337	200372	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	5	1	3	4.6	CC(C)C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL608696	200372	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	5	1	3	4.6	CC(C)C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70557795	115119	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353511	115119	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70564643	115123	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	489	8	2	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353515	115123	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	489	8	2	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70559574	115128	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353521	115128	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	5803	390	15	None	-2	2	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	854189	390	15	None	-2	2	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	CHEMBL594671	390	15	None	-2	2	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	46226275	198017	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	3	1	3	5.3	CC(C)(C)[C@H](C(=O)Nc1ncc(Br)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593344	198017	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	3	1	3	5.3	CC(C)(C)[C@H](C(=O)Nc1ncc(Br)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226294	200180	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	384	4	1	3	6.2	CC(C)(C)[C@H](C(=O)Nc1ncc(-c2ccccc2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL607315	200180	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	384	4	1	3	6.2	CC(C)(C)[C@H](C(=O)Nc1ncc(-c2ccccc2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226273	200798	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	326	3	1	3	4.7	CC(C)(C)[C@H](C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611338	200798	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	326	3	1	3	4.7	CC(C)(C)[C@H](C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226253	200799	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	328	4	1	3	4.8	CC(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611339	200799	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	328	4	1	3	4.8	CC(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226272	200242	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	337	5	2	4	3.3	CC(C)[C@H](C(=O)Nc1ncc(C(N)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL607691	200242	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	337	5	2	4	3.3	CC(C)[C@H](C(=O)Nc1ncc(C(N)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559626	115136	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	493	9	1	5	4.3	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)c1	10.1021/jm5012885
	CHEMBL3353529	115136	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	493	9	1	5	4.3	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)c1	10.1021/jm5012885
	89900365	115095	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	567	9	0	5	4.8	CC1(C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353475	115095	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	567	9	0	5	4.8	CC1(C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	89900378	115099	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	533	9	1	5	3.8	CC1(C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353479	115099	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	533	9	1	5	3.8	CC1(C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	68175329	115108	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	6	0	2	5.2	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1	10.1021/jm5012885
	CHEMBL3353489	115108	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	6	0	2	5.2	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1	10.1021/jm5012885
	70558983	115134	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	1	4	4.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)c1	10.1021/jm5012885
	CHEMBL3353527	115134	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	1	4	4.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)c1	10.1021/jm5012885
	68175946	115107	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	5	0	2	3.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(F)cc(F)c1	10.1021/jm5012885
	CHEMBL3353487	115107	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	5	0	2	3.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(F)cc(F)c1	10.1021/jm5012885
	46226236	198110	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	350	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc(C(C)(C)C)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594052	198110	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	350	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc(C(C)(C)C)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226271	198124	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	5	2	4	3.9	CC(C)[C@H](C(=O)Nc1ncc(C(=O)O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594140	198124	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	5	2	4	3.9	CC(C)[C@H](C(=O)Nc1ncc(C(=O)O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	2397905	198182	2	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594524	198182	2	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	4307629	200645	43	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610463	200645	43	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46225340	198064	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	0	3	4.2	CC(C)[C@H](C(=O)N(C)c1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593733	198064	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	0	3	4.2	CC(C)[C@H](C(=O)N(C)c1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70562873	115133	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	475	9	2	3	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)c1	10.1021/jm5012885
	CHEMBL3353526	115133	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	475	9	2	3	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)c1	10.1021/jm5012885
	46226382	198265	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	3	1	3	4.8	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCCC1	10.1016/j.bmcl.2009.11.112
	CHEMBL595000	198265	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	3	1	3	4.8	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCCC1	10.1016/j.bmcl.2009.11.112
	46226338	198151	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	5	1	3	4.3	O=C(Nc1nccs1)[C@@H](CC1CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594302	198151	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	5	1	3	4.3	O=C(Nc1nccs1)[C@@H](CC1CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	57520598	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	8417	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	CHEMBL3353541	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	DB15406	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	70566934	115144	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	487	9	2	4	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353538	115144	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	487	9	2	4	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	70556909	115142	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	521	9	1	6	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353535	115142	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	521	9	1	6	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	1058	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	176	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	21980959	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	4211	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	CHEMBL539	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	DB03166	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	10107	3808	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity in a BRET-based β-arrestin-2 recruitment assay.Agonist activity in a BRET-based β-arrestin-2 recruitment assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3808	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity in a BRET-based β-arrestin-2 recruitment assay.Agonist activity in a BRET-based β-arrestin-2 recruitment assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	10107	3808	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity in a cAMP inhibition assay.Agonist activity in a cAMP inhibition assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3808	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity in a cAMP inhibition assay.Agonist activity in a cAMP inhibition assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	6500	35	109	None	-47	2	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	0.9	OC(=O)C1(C)CC1	21220428
	81326	35	109	None	-47	2	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	0.9	OC(=O)C1(C)CC1	21220428
	CHEMBL4516837	35	109	None	-47	2	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	0.9	OC(=O)C1(C)CC1	21220428
	1061	2983	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	7991	2983	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	CHEMBL268736	2983	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	DB02406	2983	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	1059	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	1059	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	1059	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	1059	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	264	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	264	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	264	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	264	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	CHEMBL14227	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	CHEMBL14227	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	CHEMBL14227	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	CHEMBL14227	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	DB03568	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	DB03568	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	DB03568	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	DB03568	737	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	125468	2062	0	None	-	1	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	1.0	C/C(=C\C)/C(=O)O	21220428
	6499	2062	0	None	-	1	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	1.0	C/C(=C\C)/C(=O)O	21220428
	CHEMBL52416	2062	0	None	-	1	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	1.0	C/C(=C\C)/C(=O)O	21220428
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	1032	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	1032	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	1032	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	1032	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	1062	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	1062	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	1062	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	1062	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	CHEMBL14021	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	CHEMBL14021	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	CHEMBL14021	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	CHEMBL14021	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	DB03766	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	DB03766	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	DB03766	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	DB03766	3124	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	5803	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	18818303
	5803	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	21498659
	854189	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	18818303
	854189	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	21498659
	CHEMBL594671	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	18818303
	CHEMBL594671	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	21498659
	3420	3379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	18818303
	3420	3379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	23066016
	46226252	3379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	18818303
	46226252	3379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	23066016
	CHEMBL594525	3379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	18818303
	CHEMBL594525	3379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	23066016
	10107	3808	0	None	-1	2	Mouse	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3808	0	None	-1	2	Mouse	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	6488	999	0	None	-	1	Rat	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	474	8	1	4	5.9	OC(=O)CC(C(=O)N(c1scc(n1)c1cc(Cl)ccc1Cl)C1CC1)Cc1ccccc1	23589301
	67209274	999	0	None	-	1	Rat	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	474	8	1	4	5.9	OC(=O)CC(C(=O)N(c1scc(n1)c1cc(Cl)ccc1Cl)C1CC1)Cc1ccccc1	23589301
	1060	2050	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	6590	2050	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	CHEMBL108778	2050	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	DB02531	2050	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	57520598	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	57520598	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	8417	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	8417	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	CHEMBL3353541	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	CHEMBL3353541	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	DB15406	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	DB15406	1774	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	12655	3809	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Measuring antagonism of agonist-induced GTPγS incorporation by liquid scintillation spectroscopy.Measuring antagonism of agonist-induced GTPγS incorporation by liquid scintillation spectroscopy.	Guide to Pharmacology	419	8	2	5	2.7	O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3	None
	12655	3809	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.	Guide to Pharmacology	419	8	2	5	2.7	O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3	None
	53308747	795	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	7	2	2	4.1	OC(=O)C[C@@H](NC(=O)Cc1cccc(c1)Cl)Cc1ccc(cc1)C(F)(F)F	23066016
	6487	795	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	7	2	2	4.1	OC(=O)C[C@@H](NC(=O)Cc1cccc(c1)Cl)Cc1ccc(cc1)C(F)(F)F	23066016

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	137633536	155742	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human FFA2 receptor by FLIPR assayAgonist activity at human FFA2 receptor by FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	155742	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human FFA2 receptor by FLIPR assayAgonist activity at human FFA2 receptor by FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	57520598	1774	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	8417	1774	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	CHEMBL3353541	1774	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	DB15406	1774	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	145951537	162147	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4170829	162147	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	145957346	161409	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159019	161409	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	67209751	161608	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4162307	161608	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898644	162535	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4177037	162535	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	53302677	162285	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4172928	162285	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67209297	162236	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4172349	162236	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	138319694	162512	23	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162512	23	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	117898634	161833	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4165748	161833	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	67209218	162318	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4173387	162318	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145951986	162142	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4170748	162142	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145953670	162000	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168456	162000	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	67210172	161896	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4166818	161896	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67258265	162166	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171128	162166	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	117898651	162331	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4173663	162331	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	46235794	162373	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4174307	162373	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145953626	161949	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167577	161949	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	10107	3808	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for hFFA2.Binding affinity for hFFA2.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3808	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for hFFA2.Binding affinity for hFFA2.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908

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Main reference

Ligand source activities (1 row/activity)