GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	137642920	157558	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4086893	157558	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	134157586	153617	0	None	-3	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3985509	153617	0	None	-3	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	90407037	156734	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4076902	156734	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90405670	164131	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	425	7	1	3	5.4	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217143	164131	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	425	7	1	3	5.4	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	118707082	112496	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	4	1	3	3.3	COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311196	112496	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	4	1	3	3.3	COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	925016	112518	14	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	289	3	1	2	3.7	Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311314	112518	14	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	289	3	1	2	3.7	Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137649416	156965	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4079893	156965	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	82051616	158898	1	None	12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	158898	1	None	12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	975397	112524	9	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	335	5	1	4	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC	10.1016/j.bmcl.2014.05.012
	CHEMBL3311324	112524	9	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	335	5	1	4	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC	10.1016/j.bmcl.2014.05.012
	137634844	155563	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4063239	155563	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137640323	156424	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4073013	156424	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	137653973	158126	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	354	6	2	3	4.3	Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O	10.1016/j.bmcl.2017.01.034
	CHEMBL4093067	158126	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	354	6	2	3	4.3	Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O	10.1016/j.bmcl.2017.01.034
	134133275	143099	0	None	-8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3899885	143099	0	None	-8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	85472225	162199	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	162199	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134133797	143024	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3899190	143024	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	85472621	162241	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4172392	162241	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	145955668	161863	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4166208	161863	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	134149615	148032	0	None	1	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148032	0	None	1	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	137640701	156535	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4074388	156535	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	137636217	155540	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4063013	155540	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	137642920	157558	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4086893	157558	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	90418476	162224	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4172136	162224	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	57521919	75909	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058532	75909	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4207911	75909	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	137636217	155540	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4063013	155540	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	134138099	147277	0	None	4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3932897	147277	0	None	4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	60195036	81295	0	None	-630	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL2163924	81295	0	None	-630	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	137632299	155914	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4067368	155914	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	90406631	163871	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	503	7	1	3	6.1	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4213709	163871	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	503	7	1	3	6.1	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137643228	157699	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	8	1	5	5.2	COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4088620	157699	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	8	1	5	5.2	COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	137647721	157276	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	157276	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	59455584	156487	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4073815	156487	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90406228	163139	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4204928	163139	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	561372	58504	59	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688452	58504	59	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	86343591	163140	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4204946	163140	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	134133275	143099	0	None	8	2	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3899885	143099	0	None	8	2	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	137643958	157722	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	505	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4088889	157722	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	505	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137657488	159121	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4104082	159121	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	90418753	161834	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165803	161834	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	73777111	149166	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	149166	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	25098573	2696	5	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	5587	2696	5	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	CHEMBL463785	2696	5	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	134141270	146265	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3924759	146265	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	90418849	162134	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	7	1	4	6.5	Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1021/acsmedchemlett.7b00233
	CHEMBL4170501	162134	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	7	1	4	6.5	Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1021/acsmedchemlett.7b00233
	8190724	112517	7	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	359	4	1	3	4.3	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311313	112517	7	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	359	4	1	3	4.3	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	258072	79663	24	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	275	3	1	2	3.4	Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL2131154	79663	24	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	275	3	1	2	3.4	Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	91824000	112516	7	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311312	112516	7	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1	10.1016/j.bmcl.2014.05.012
	137647721	157276	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	157276	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	57521919	75909	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058532	75909	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4207911	75909	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	54586011	61464	0	None	-14	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773257	61464	0	None	-14	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	137640701	156535	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4074388	156535	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134151903	152810	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3978465	152810	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	73777069	142125	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	142125	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	73777174	149909	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	149909	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	134136175	142136	0	None	1	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3892019	142136	0	None	1	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	643684	107016	59	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL3186422	107016	59	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	86343965	163248	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4206168	163248	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	90418650	156801	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4077787	156801	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	85470884	163441	0	None	2	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	163441	0	None	2	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134149615	148032	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148032	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	90406583	164098	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	416	7	1	4	4.9	N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4216721	164098	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	416	7	1	4	4.9	N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F	10.1016/j.bmcl.2018.02.013
	134144000	149664	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	149664	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134154415	152150	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	CHEMBL3972870	152150	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	137640328	156430	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	CHEMBL4073078	156430	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	134133675	142718	0	None	2	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896714	142718	0	None	2	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	1050	1863	86	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	11595431	1863	86	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	CHEMBL207881	1863	86	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	85471695	158111	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4092882	158111	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	137657736	159079	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4103573	159079	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	90405989	155407	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4061340	155407	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	137653883	157964	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	493	7	1	4	6.6	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F	10.1016/j.bmcl.2017.06.028
	CHEMBL4091291	157964	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	493	7	1	4	6.6	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F	10.1016/j.bmcl.2017.06.028
	11195	3807	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	3807	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	3807	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	87055315	165193	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246850	165193	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	145986046	165348	0	None	19	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250196	165348	0	None	19	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	142738582	183928	0	None	-42	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4847662	183928	0	None	-42	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	134157207	153665	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3985939	153665	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	134135468	143930	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	143930	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	134145700	148207	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3940429	148207	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134155067	150762	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3960738	150762	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137646995	157279	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	391	7	1	4	5.0	O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4083499	157279	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	391	7	1	4	5.0	O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1	10.1016/j.bmcl.2017.06.028
	137660451	158686	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4099026	158686	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134151115	151655	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968537	151655	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	90418653	136975	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL3754160	136975	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	86343594	163034	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4203544	163034	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	137641343	156503	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	156503	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134132142	144324	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	144324	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	134132142	144324	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3909872	144324	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57522038	3812	54	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	3812	54	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	3812	54	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	137635671	155438	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4061699	155438	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137632299	155914	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4067368	155914	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	137661886	158768	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4099943	158768	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	137657968	159033	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4103081	159033	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90418139	162019	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4168786	162019	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	90406219	163751	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	469	7	1	3	5.8	O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4212281	163751	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	469	7	1	3	5.8	O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	90406961	163219	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4205879	163219	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	90406842	164143	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	427	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4217252	164143	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	427	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C	10.1016/j.bmcl.2018.02.013
	85472222	162504	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	437	9	1	4	6.7	CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4176414	162504	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	437	9	1	4	6.7	CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	51349861	58506	0	None	-77	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL1688454	58506	0	None	-77	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	10466	166106	72	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	CHEMBL4281719	166106	72	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	134153222	151981	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3971461	151981	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	134134149	142831	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3897776	142831	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	134155480	150707	0	None	38	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3960231	150707	0	None	38	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137648785	157056	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4080995	157056	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137655521	158431	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	467	8	1	4	6.1	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4096332	158431	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	467	8	1	4	6.1	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	25109512	189162	0	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	CHEMBL515995	189162	0	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	137641343	156503	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	156503	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	90418782	162521	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4176642	162521	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	90407441	163151	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	417	7	1	3	6.0	Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4205035	163151	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	417	7	1	3	6.0	Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	54580132	61460	0	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	CHEMBL1773253	61460	0	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	7789	100205	79	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	300	16	2	2	5.3	CCCCCCC(O)CCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL292352	100205	79	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	300	16	2	2	5.3	CCCCCCC(O)CCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	86343595	164132	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217161	164132	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137646145	157468	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4085643	157468	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	57521809	75896	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058520	75896	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL4210970	75896	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	86294762	163552	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4209823	163552	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	134133355	142992	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3898962	142992	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137657488	159121	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4104082	159121	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	134146386	148363	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3941726	148363	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	46892131	144126	2	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	144126	2	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	134143163	145199	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3916564	145199	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	90406575	163791	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	455	8	1	4	5.4	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4212717	163791	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	455	8	1	4	5.4	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	134136175	142136	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3892019	142136	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	145983493	164941	0	None	371	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4240607	164941	0	None	371	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134146021	148520	0	None	-5	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3942922	148520	0	None	-5	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	134154330	152335	0	None	1	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3974501	152335	0	None	1	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	137638355	156275	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	156275	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134147174	149159	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3947787	149159	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	137649360	156832	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4078286	156832	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	90418662	158383	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4095819	158383	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	73777175	143365	0	None	1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	143365	0	None	1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	57521814	75901	0	None	10	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058525	75901	0	None	10	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	90418662	158383	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4095819	158383	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	85470884	163441	0	None	-2	5	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	163441	0	None	-2	5	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	57521808	75895	0	None	-3	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL2058519	75895	0	None	-3	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	57521809	75896	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058520	75896	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4210970	75896	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	90442468	163919	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	456	8	1	5	4.8	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4214224	163919	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	456	8	1	5	4.8	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134156096	150903	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3961950	150903	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137638355	156275	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	156275	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137642604	157959	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	157959	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137632403	155751	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4065447	155751	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	84481843	112523	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	5	1	3	4.2	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311322	112523	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	5	1	3	4.2	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	8190727	112526	6	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	347	3	1	4	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311326	112526	6	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	347	3	1	4	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	137632403	155751	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4065447	155751	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	134153562	152179	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	CHEMBL3973101	152179	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	87055315	165193	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120Agonist activity at human GPR120	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246850	165193	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120Agonist activity at human GPR120	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	73777156	152171	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	152171	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	137642604	157959	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	157959	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	90418651	161851	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4166012	161851	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	59455552	155488	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062462	155488	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134154417	152160	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3972973	152160	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	57521813	75900	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058524	75900	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	134134846	143695	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3904654	143695	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	54582149	61462	0	None	-33	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773255	61462	0	None	-33	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	134146958	149065	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3947070	149065	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73777085	152684	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	152684	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	90418650	156801	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4077787	156801	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	90418650	156801	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4077787	156801	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	57521913	75902	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058526	75902	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	134145750	148601	0	None	3	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3943430	148601	0	None	3	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134141029	146622	0	None	4	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3927879	146622	0	None	4	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	145984594	165369	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	436	9	1	6	4.2	CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250664	165369	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	436	9	1	6	4.2	CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1	10.1016/j.bmcl.2018.06.047
	134156455	153775	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3986721	153775	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	73777153	142279	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	142279	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	137645347	157248	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	7	1	2	6.2	Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4083233	157248	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	7	1	2	6.2	Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134147107	149332	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3949142	149332	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	25150014	3810	48	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	3952	3810	48	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	CHEMBL449588	3810	48	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	137646188	157051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	CHEMBL4080936	157051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	137660451	158686	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4099026	158686	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	57521915	75904	0	None	15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058528	75904	0	None	15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	11195	3807	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	3807	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	3807	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	134152545	152931	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3979588	152931	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	137636733	155651	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	CHEMBL4064298	155651	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	90442039	162347	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4173940	162347	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	57521916	75905	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058529	75905	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	25098573	2696	5	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	5587	2696	5	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	CHEMBL463785	2696	5	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	23136411	58509	0	None	-11	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688457	58509	0	None	-11	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	134143370	145258	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3916986	145258	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	145983824	165175	0	None	-6	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246334	165175	0	None	-6	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134129938	141896	0	None	263	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890089	141896	0	None	263	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134153298	151822	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3970166	151822	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	85472225	162199	0	None	2	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	162199	0	None	2	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134153546	152037	0	None	8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971857	152037	0	None	8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137636733	155651	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	CHEMBL4064298	155651	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	82051652	158040	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4092090	158040	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137654721	158181	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	CHEMBL4093589	158181	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	711134	112513	16	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311305	112513	16	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137646188	157051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	CHEMBL4080936	157051	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	134155277	150781	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3961009	150781	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	1049	360	70	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	4618	360	70	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	5280934	360	70	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	CHEMBL8739	360	70	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	DB00132	360	70	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	90406335	163267	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4206369	163267	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F	10.1016/j.bmcl.2018.02.013
	134138318	147475	0	None	1	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3934450	147475	0	None	1	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	134144214	149813	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953203	149813	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	59455555	158158	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4093383	158158	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	73776979	142815	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3897637	142815	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	137654721	158181	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	CHEMBL4093589	158181	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	82051652	158040	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4092090	158040	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137657736	159079	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4103573	159079	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	145986262	165281	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	8	1	4	4.7	O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F	10.1016/j.bmcl.2018.06.047
	CHEMBL4248845	165281	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	8	1	4	4.7	O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F	10.1016/j.bmcl.2018.06.047
	134154473	151830	0	None	218	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3970238	151830	0	None	218	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134139171	145718	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3920591	145718	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	86343964	163057	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	421	7	1	3	5.5	Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4203774	163057	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	421	7	1	3	5.5	Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1	10.1016/j.bmcl.2018.02.013
	137647294	157397	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	8	1	4	6.9	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4084679	157397	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	8	1	4	6.9	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C	10.1016/j.bmcl.2017.06.028
	90407659	163670	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	440	7	1	4	5.1	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4211144	163670	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	440	7	1	4	5.1	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134157586	153617	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3985509	153617	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	137636575	155348	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4060663	155348	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134133675	142718	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896714	142718	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	90404813	163945	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	473	7	1	3	6.3	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	CHEMBL4214698	163945	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	473	7	1	3	6.3	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	57521812	75899	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL2058523	75899	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	137633536	155742	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	155742	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	134154330	152335	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3974501	152335	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134148110	149026	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3946820	149026	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134138802	147374	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	147374	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	46892131	144126	2	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	144126	2	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	137661388	158681	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4098969	158681	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	134133297	143235	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3900990	143235	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57521811	75898	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	CHEMBL2058522	75898	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	24825492	148998	0	None	-9	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL394666	148998	0	None	-9	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	85472227	161627	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162566	161627	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	134149615	148032	0	None	1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148032	0	None	1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	73777174	149909	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	149909	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	145960576	161591	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161929	161591	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134145195	149878	0	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	5	1	5	4.4	Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953859	149878	0	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	5	1	5	4.4	Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1	10.1016/j.bmcl.2016.10.054
	1052	2280	81	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	3323	2280	81	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	5280450	2280	81	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	CHEMBL267476	2280	81	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	DB14104	2280	81	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	900631	112525	17	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	3	1	4	3.2	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311325	112525	17	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	3	1	4	3.2	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	118707173	112527	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	331	6	1	3	3.8	C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311327	112527	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	331	6	1	3	3.8	C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	137633536	155742	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	155742	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	137661388	158681	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4098969	158681	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	1050	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	11595431	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	CHEMBL207881	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	825631	112514	15	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311306	112514	15	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1	10.1016/j.bmcl.2014.05.012
	841618	112521	18	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	3	1	2	4.1	Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311318	112521	18	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	3	1	2	4.1	Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	134141270	146265	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3924759	146265	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	134145412	148727	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3944507	148727	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	134147601	149484	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3950444	149484	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	1049	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	4618	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	5280934	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	CHEMBL8739	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	DB00132	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	134143899	149694	0	None	1	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3952316	149694	0	None	1	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	73777063	1128	34	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	1128	34	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	1128	34	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	134152336	152910	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3979448	152910	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	117886639	147906	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	147906	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	90417528	161611	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	9	1	4	7.2	CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162353	161611	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	9	1	4	7.2	CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	85472359	161568	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161536	161568	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	134148736	148010	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3938783	148010	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	134156096	150903	0	None	5	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3961950	150903	0	None	5	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137649360	156832	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4078286	156832	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	86343961	163724	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	435	7	1	3	5.8	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4211967	163724	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	435	7	1	3	5.8	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C	10.1016/j.bmcl.2018.02.013
	145985748	165080	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	444	9	1	4	5.4	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4243863	165080	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	444	9	1	4	5.4	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134156727	153088	0	None	-4	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	153088	0	None	-4	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	134151115	151655	0	None	4	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968537	151655	0	None	4	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	137631865	155781	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4065769	155781	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	1050	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	11595431	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	CHEMBL207881	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	73777065	146711	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3928591	146711	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	134146021	148520	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3942922	148520	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	73777135	149825	0	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	149825	0	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	137643339	157487	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	157487	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	90406970	164213	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4218078	164213	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134146720	148587	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3943315	148587	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	23136477	58507	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688455	58507	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4213909	58507	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	134132711	144393	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	144393	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	134145778	148803	0	None	13	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3945213	148803	0	None	13	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	137657972	159045	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	159045	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	23136477	58507	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL1688455	58507	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4213909	58507	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	118707084	112498	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	321	5	1	4	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311198	112498	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	321	5	1	4	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	8190712	112522	9	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	5	1	2	4.4	CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311319	112522	9	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	5	1	2	4.4	CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137643339	157487	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	157487	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	956298	112512	5	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	319	4	1	4	2.9	COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C	10.1016/j.bmcl.2014.05.012
	CHEMBL3311303	112512	5	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	319	4	1	4	2.9	COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C	10.1016/j.bmcl.2014.05.012
	137657972	159045	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	159045	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	134131874	144312	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3909773	144312	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	86281122	163763	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4212409	163763	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1	10.1016/j.bmcl.2018.02.013
	137660302	158879	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4101135	158879	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	137638176	156180	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	7	1	4	6.1	Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1016/j.bmcl.2017.06.028
	CHEMBL4070355	156180	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	7	1	4	6.1	Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1016/j.bmcl.2017.06.028
	117873187	151800	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3969920	151800	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	87054900	148217	0	None	1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3940493	148217	0	None	1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	90418278	161817	12	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	161817	12	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	73777175	143365	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	143365	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	60195039	81367	0	None	-181	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164240	81367	0	None	-181	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	134134229	142711	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	142711	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134134229	142711	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896657	142711	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	86281125	163508	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4209308	163508	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	57522038	3812	54	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	3812	54	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	3812	54	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	117886649	151534	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3967504	151534	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	134142866	145097	0	None	2	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3915765	145097	0	None	2	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	57521914	75903	0	None	-6	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058527	75903	0	None	-6	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	60195125	3813	5	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	9149	3813	5	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	CHEMBL2164242	3813	5	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	73777135	149825	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	149825	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73776995	148198	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3940359	148198	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	24825509	87504	0	None	-29	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234057	87504	0	None	-29	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	134154953	150732	0	None	7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3960369	150732	0	None	7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	86343963	164181	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217669	164181	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134155950	150546	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959068	150546	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	145984009	165026	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	418	7	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4242595	165026	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	418	7	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1	10.1016/j.bmcl.2018.06.047
	134157207	153665	0	None	3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3985939	153665	0	None	3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57522038	3812	54	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	6490	3812	54	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	CHEMBL2058533	3812	54	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	134157563	153461	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3984072	153461	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	54584098	61461	5	None	-5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL1773254	61461	5	None	-5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	54583098	61465	0	None	-70	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1773258	61465	0	None	-70	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	134157563	153461	0	None	-1	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3984072	153461	0	None	-1	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	73777069	142125	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	142125	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	134138318	147475	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3934450	147475	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	134144000	149664	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	149664	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	86281123	163185	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	439	7	1	3	5.7	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4205429	163185	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	439	7	1	3	5.7	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	137646553	157360	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4084333	157360	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	118707083	112497	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	325	4	1	3	3.8	COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311197	112497	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	325	4	1	3	3.8	COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	743974	112515	66	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	112515	66	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137638995	156411	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	156411	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	23136401	158577	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	158577	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	145984445	164897	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	9	1	4	5.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4239572	164897	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	9	1	4	5.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134138281	147241	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3932664	147241	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	90417978	161423	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4159180	161423	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	73777153	142279	0	None	2	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	142279	0	None	2	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	57521918	75908	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058531	75908	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	54582150	61466	0	None	-22	2	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1773259	61466	0	None	-22	2	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	59455584	156487	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4073815	156487	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	137646553	157360	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4084333	157360	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134132951	144077	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3907996	144077	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	137638995	156411	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	156411	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	90407027	163631	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	437	7	1	3	6.3	Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4210752	163631	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	437	7	1	3	6.3	Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	54585039	61459	5	None	-17	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL1773252	61459	5	None	-17	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	134143899	149694	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3952316	149694	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	87054900	148217	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3940493	148217	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	90406418	164014	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	CHEMBL4215446	164014	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	134131620	141888	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890035	141888	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	23136401	158577	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	158577	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	90418513	162061	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169436	162061	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	23136363	58510	0	None	-14	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688458	58510	0	None	-14	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	134150245	151701	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968947	151701	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137643146	157508	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4086174	157508	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	73777085	152684	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	152684	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73776997	153734	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3986483	153734	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	23346507	87846	1	None	-30	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL234834	87846	1	None	-30	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	57521810	75897	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058521	75897	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	24825484	87549	0	None	-208	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234269	87549	0	None	-208	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	73777111	149166	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	149166	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	137642184	157944	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4091118	157944	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	134156727	153088	0	None	4	2	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	153088	0	None	4	2	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	137637576	155510	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	155510	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137658634	158844	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4100773	158844	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	137643146	157508	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4086174	157508	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	134144214	149813	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953203	149813	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	59455552	155488	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062462	155488	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134134229	142711	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	142711	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134134229	142711	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896657	142711	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	137637576	155510	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	155510	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137658634	158844	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4100773	158844	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	57522038	3812	54	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	3812	54	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	3812	54	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	137638911	156176	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	156176	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137656526	159194	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	159194	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	743974	112515	66	None	-3	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	112515	66	None	-3	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	46941175	61468	20	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL1773261	61468	20	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	46941175	61468	20	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773261	61468	20	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	3518281	112520	11	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	293	3	1	2	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311317	112520	11	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	293	3	1	2	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	137642184	157944	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4091118	157944	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	145985122	165344	0	None	17	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250132	165344	0	None	17	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134147174	149159	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3947787	149159	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	134145412	148727	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3944507	148727	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	73777156	152171	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	152171	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	134143163	145199	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3916564	145199	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	137638911	156176	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	156176	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	134134149	142831	0	None	2	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3897776	142831	0	None	2	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	137640328	156430	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	CHEMBL4073078	156430	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	117886639	147906	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	147906	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	118184919	162311	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4173280	162311	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	54586984	61463	0	None	-34	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773256	61463	0	None	-34	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	134139171	145718	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3920591	145718	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	137661886	158768	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4099943	158768	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	90418886	162358	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	423	9	1	4	6.1	CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4174122	162358	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	423	9	1	4	6.1	CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	137656526	159194	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	159194	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	145985686	164867	0	None	354	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4238809	164867	0	None	354	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	137648785	157056	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4080995	157056	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134153986	151962	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971308	151962	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134153562	152179	0	None	2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	CHEMBL3973101	152179	0	None	2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	134140073	145776	0	None	1	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3921062	145776	0	None	1	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	134135468	143930	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	143930	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	57521702	75894	0	None	-11	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	CHEMBL2058518	75894	0	None	-11	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	137636575	155348	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4060663	155348	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137635671	155438	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4061699	155438	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	85471695	158111	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4092882	158111	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	85470884	163441	0	None	-7	5	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	163441	0	None	-7	5	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134155847	150558	0	None	63	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959144	150558	0	None	63	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134132711	144393	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	144393	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	137636167	155434	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	155434	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	134142450	144901	0	None	10	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3914253	144901	0	None	10	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	137660302	158879	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4101135	158879	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	90418333	162093	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169851	162093	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	57522038	3812	54	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	3812	54	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	3812	54	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	57839754	157262	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083325	157262	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	90407037	156734	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4076902	156734	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	3893	2246	92	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	4642	2246	92	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	5534	2246	92	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL108766	2246	92	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	DB03017	2246	92	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	59455555	158158	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4093383	158158	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134149615	148032	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148032	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	90418278	161817	12	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	161817	12	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134155277	150781	0	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3961009	150781	0	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	134133992	143195	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3900705	143195	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134133297	143235	0	None	3	3	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3900990	143235	0	None	3	3	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	977153	51130	15	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	339	4	1	3	4.1	COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl	10.1016/j.bmcl.2014.05.012
	CHEMBL1581959	51130	15	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	339	4	1	3	4.1	COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl	10.1016/j.bmcl.2014.05.012
	137636167	155434	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	155434	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	57839754	157262	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083325	157262	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	743974	112515	66	None	-1	3	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	112515	66	None	-1	3	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	8190702	112519	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	4	1	3	3.6	CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311316	112519	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	4	1	3	3.6	CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	85470884	163441	0	None	2	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	163441	0	None	2	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137634829	155519	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062742	155519	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134154417	152160	0	None	2	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3972973	152160	0	None	2	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137631865	155781	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4065769	155781	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134145750	148601	0	None	-3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3943430	148601	0	None	-3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134142450	144901	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3914253	144901	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	134140073	145776	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3921062	145776	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	46892131	144126	2	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	144126	2	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	51350138	58526	0	None	-660	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL1688473	58526	0	None	-660	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	86343792	164118	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	475	7	1	3	6.3	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2018.02.013
	CHEMBL4216937	164118	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	475	7	1	3	6.3	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2018.02.013
	60195038	81366	0	None	-912	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164239	81366	0	None	-912	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	85472487	161915	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4167097	161915	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	51350272	58518	0	None	-107	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1688465	58518	0	None	-107	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	145985219	164901	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	420	9	1	4	5.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4239630	164901	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	420	9	1	4	5.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	90406893	163872	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	454	8	1	4	5.3	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4213710	163872	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	454	8	1	4	5.3	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134148736	148010	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3938783	148010	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	86281121	163449	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	451	7	1	3	6.4	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4208442	163449	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	451	7	1	3	6.4	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	134138802	147374	0	None	4	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	147374	0	None	4	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	137649416	156965	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4079893	156965	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	134150245	151701	0	None	6	3	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968947	151701	0	None	6	3	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137657968	159033	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4103081	159033	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90407263	163036	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4203559	163036	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	57521917	75907	0	None	-8	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058530	75907	0	None	-8	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	90418067	161769	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	9	1	5	5.6	CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4164722	161769	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	9	1	5	5.6	CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	86343790	163376	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	441	7	1	3	5.9	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl	10.1016/j.bmcl.2018.02.013
	CHEMBL4207603	163376	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	441	7	1	3	5.9	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl	10.1016/j.bmcl.2018.02.013
	145984796	165178	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	9	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246396	165178	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	9	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	90405989	155407	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4061340	155407	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	60195040	81368	0	None	-5248	2	Human	4.0	pEC50	=	4.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164241	81368	0	None	-5248	2	Human	4.0	pEC50	=	4.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	134132142	144324	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	144324	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	134132142	144324	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3909872	144324	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	145971522	162554	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4177287	162554	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	134142866	145097	0	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3915765	145097	0	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	57522038	3812	54	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	3812	54	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	3812	54	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	137634844	155563	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4063239	155563	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	23136363	58510	0	None	-14	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL1688458	58510	0	None	-14	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	134141029	146622	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3927879	146622	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	82051616	158898	1	None	12	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	158898	1	None	12	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	73777063	1128	34	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	1128	34	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	1128	34	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	85472618	161748	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4164509	161748	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	137640323	156424	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4073013	156424	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	5588	1823	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	9976563	1823	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	CHEMBL513978	1823	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	11531145	1824	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	19471906
	11531145	1824	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	20685848
	5589	1824	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	19471906
	5589	1824	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	20685848
	1054	2861	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	3400	2861	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	445639	2861	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	CHEMBL8659	2861	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	1052	2280	81	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	3323	2280	81	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	5280450	2280	81	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	CHEMBL267476	2280	81	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	DB14104	2280	81	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	11195	3807	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	86280676	3807	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	CHEMBL3941880	3807	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	11195	3807	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	86280676	3807	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	CHEMBL3941880	3807	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	73777063	1128	34	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	8418	1128	34	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	CHEMBL3919973	1128	34	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	1054	2861	0	None	-1	2	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	3400	2861	0	None	-1	2	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	445639	2861	0	None	-1	2	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	CHEMBL8659	2861	0	None	-1	2	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	1049	360	70	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	4618	360	70	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	5280934	360	70	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	CHEMBL8739	360	70	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	DB00132	360	70	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	11005	2644	100	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	2806	2644	100	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	CHEMBL111077	2644	100	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	DB08231	2644	100	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	1050	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	1050	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	11595431	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	11595431	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	CHEMBL207881	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	CHEMBL207881	1863	86	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	1049	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	4618	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	5280934	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	CHEMBL8739	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	DB00132	360	70	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	1052	2280	81	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	3323	2280	81	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	5280450	2280	81	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	CHEMBL267476	2280	81	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	DB14104	2280	81	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	25098573	2696	5	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110
	5587	2696	5	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110
	CHEMBL463785	2696	5	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	134154473	151830	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3970238	151830	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73776979	142815	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3897637	142815	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	137638318	156181	0	None	-	1	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4070359	156181	0	None	-	1	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	127031569	138641	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787580	138641	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	145971522	162554	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4177287	162554	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	134129938	141896	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890089	141896	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	156011529	176813	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	420	7	1	3	6.2	CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1	10.1016/j.bmc.2019.115263
	CHEMBL4638249	176813	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	420	7	1	3	6.2	CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1	10.1016/j.bmc.2019.115263
	134132142	144324	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	144324	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	73777175	143365	0	None	-	0	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	143365	0	None	-	0	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	85472621	162241	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4172392	162241	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	66562488	89926	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
	CHEMBL2386364	89926	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
	73777153	142279	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	142279	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	137640163	156294	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4071523	156294	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	11195	3807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	3807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	3807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	134153222	151981	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3971461	151981	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	11195	3807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	3807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	3807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	145955668	161863	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4166208	161863	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	162644046	181218	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	361	4	2	5	3.0	Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4778107	181218	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	361	4	2	5	3.0	Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134146720	148587	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3943315	148587	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134146958	149065	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3947070	149065	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134147601	149484	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3950444	149484	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	90418139	162019	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4168786	162019	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	90418650	156801	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4077787	156801	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	134132711	144393	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	144393	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	73345869	89917	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386355	89917	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	134133992	143195	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3900705	143195	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73777135	149825	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	149825	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73777175	143365	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	143365	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	90418653	136975	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL3754160	136975	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	90418278	161817	12	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	161817	12	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	25150014	3810	48	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	3952	3810	48	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	CHEMBL449588	3810	48	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	134151903	152810	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3978465	152810	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	134133797	143024	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3899190	143024	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	162674347	182529	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4794951	182529	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2020.127650
	90418651	161851	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4166012	161851	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	57522038	3812	54	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
	6490	3812	54	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
	CHEMBL2058533	3812	54	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
	66562385	89923	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386361	89923	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	134134229	142711	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	142711	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134138802	147374	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	147374	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	134145071	149622	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3951664	149622	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	134152545	152931	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3979588	152931	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	134154975	150856	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	362	5	1	4	4.0	O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3961620	150856	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	362	5	1	4	4.0	O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	90418513	162061	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169436	162061	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	134155950	150546	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959068	150546	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	134155847	150558	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959144	150558	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134155480	150707	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3960231	150707	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137654131	158456	0	None	-	0	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4096579	158456	0	None	-	0	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	134143370	145258	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3916986	145258	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	127031003	138601	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787072	138601	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	8452407	179795	6	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	293	4	2	5	2.0	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-]	10.1016/j.bmcl.2020.127650
	CHEMBL4751828	179795	6	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	293	4	2	5	2.0	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-]	10.1016/j.bmcl.2020.127650
	78426052	177508	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	4	6.4	Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1	10.1016/j.bmc.2019.115263
	CHEMBL4647832	177508	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	4	6.4	Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1	10.1016/j.bmc.2019.115263
	90418782	162521	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4176642	162521	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	73777153	142279	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	142279	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	66562288	138467	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785637	138467	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	137633489	156047	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	CHEMBL4068825	156047	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	134148110	149026	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3946820	149026	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134134229	142711	0	None	-	0	Mouse	7.7	pEC50	=	7.7	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	142711	0	None	-	0	Mouse	7.7	pEC50	=	7.7	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	90418753	161834	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165803	161834	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	73776997	153734	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3986483	153734	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	16777240	179189	2	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	330	3	2	3	3.4	Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4744629	179189	2	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	330	3	2	3	3.4	Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	156016724	177133	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.bmc.2019.115263
	CHEMBL4642294	177133	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.bmc.2019.115263
	73777111	149166	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	149166	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	134153546	152037	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971857	152037	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137633536	155742	0	None	-	0	Rat	6.6	pEC50	=	6.6	Binding	Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	155742	0	None	-	0	Rat	6.6	pEC50	=	6.6	Binding	Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	134145778	148803	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3945213	148803	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	134156727	153088	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	153088	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	137650498	156768	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4077353	156768	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
	134134846	143695	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3904654	143695	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	137641818	157650	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4087992	157650	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	73777085	152684	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	152684	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	137651638	156667	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4076190	156667	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	137646368	157472	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4085695	157472	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	134154953	150732	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3960369	150732	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	66562289	138477	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785764	138477	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	134153067	151712	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3969073	151712	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	78425909	177090	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	398	8	1	3	6.1	O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2	10.1016/j.bmc.2019.115263
	CHEMBL4641735	177090	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	398	8	1	3	6.1	O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2	10.1016/j.bmc.2019.115263
	117873187	151800	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3969920	151800	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	73777156	152171	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	152171	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	837245	10484	41	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL1170012	10484	41	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	73356514	89930	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386368	89930	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	73345870	89931	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386369	89931	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	73354950	89933	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386370	89933	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	73348895	89934	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386371	89934	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	73777111	149166	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	149166	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	156635006	178950	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	400	4	2	4	4.0	Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4741544	178950	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	400	4	2	4	4.0	Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	117886639	147906	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	147906	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	66562392	89927	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
	CHEMBL2386365	89927	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
	134138281	147241	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3932664	147241	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	134138802	147374	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	147374	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	134153986	151962	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971308	151962	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	117886649	151534	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3967504	151534	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	118184919	162311	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4173280	162311	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	127030344	138602	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787110	138602	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
	127031002	138544	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786526	138544	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	134132142	144324	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	144324	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	674995	142460	13	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3894632	142460	13	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	162672256	182280	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	346	4	2	4	3.1	COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4791789	182280	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	346	4	2	4	3.1	COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	137648938	156858	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4078553	156858	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	73777156	152171	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	152171	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	71655293	89916	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386354	89916	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	71655227	89924	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386362	89924	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	134147107	149332	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3949142	149332	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	156635004	179122	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	344	4	2	3	3.7	CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4743951	179122	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	344	4	2	3	3.7	CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	162674533	182873	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4799103	182873	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	134144000	149664	0	None	-	0	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	149664	0	None	-	0	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134132711	144393	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	144393	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	137660172	158555	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	CHEMBL4097652	158555	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	117886639	147906	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	147906	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	127033352	138478	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785789	138478	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	137658977	158546	0	None	-	0	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4097537	158546	0	None	-	0	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	137649363	156842	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	4	5.0	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4078374	156842	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	4	5.0	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	134146386	148363	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3941726	148363	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73777174	149909	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	149909	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	90442039	162347	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4173940	162347	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	134132951	144077	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3907996	144077	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	137652399	156941	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	CHEMBL4079621	156941	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	46892131	144126	2	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	144126	2	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	134138099	147277	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3932897	147277	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	73507535	176880	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	391	6	1	3	5.5	O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1	10.1016/j.bmc.2019.115263
	CHEMBL4639009	176880	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	391	6	1	3	5.5	O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1	10.1016/j.bmc.2019.115263
	73777065	146711	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3928591	146711	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	137642248	157596	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	CHEMBL4087308	157596	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	137643731	157829	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4089919	157829	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	137658977	158546	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4097537	158546	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	73777069	142125	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	142125	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	11195	3807	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	3807	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	3807	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	67072752	86088	0	None	-	1	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315528	86088	0	None	-	1	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	127033353	138608	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787151	138608	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	73777135	149825	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	149825	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	137632610	155793	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4065890	155793	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	743974	112515	66	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3311308	112515	66	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1021/acs.jmedchem.6b00685
	162673626	182601	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4795755	182601	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134144000	149664	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	149664	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134154415	152150	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	CHEMBL3972870	152150	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	118679768	177036	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.bmc.2019.115263
	CHEMBL4641038	177036	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.bmc.2019.115263
	46908122	151026	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	334	3	0	4	3.8	O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3963275	151026	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	334	3	0	4	3.8	O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	162676836	182911	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	3	3	4	2.8	Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4799668	182911	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	3	3	4	2.8	Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	90418476	162224	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4172136	162224	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	137645249	157057	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4080998	157057	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	137648938	156858	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4078553	156858	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	156635003	180344	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4758125	180344	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	137657813	159215	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4105241	159215	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	134147328	149505	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3950610	149505	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	162649435	179450	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4747554	179450	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	73777085	152684	0	None	-	0	Mouse	5.3	pEC50	=	5.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	152684	0	None	-	0	Mouse	5.3	pEC50	=	5.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	2843133	147102	45	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3931570	147102	45	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
	73777063	1128	34	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	1128	34	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	1128	34	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	137657813	159215	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4105241	159215	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	134141650	146154	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3923955	146154	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	66562390	89920	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
	CHEMBL2386358	89920	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
	162645828	179073	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4743323	179073	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
	73776995	148198	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3940359	148198	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	90118275	176796	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	377	9	1	4	4.8	O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1	10.1016/j.bmc.2019.115263
	CHEMBL4637969	176796	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	377	9	1	4	4.8	O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1	10.1016/j.bmc.2019.115263
	156021563	177441	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.bmc.2019.115263
	CHEMBL4646784	177441	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.bmc.2019.115263
	134155067	150762	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3960738	150762	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134156727	153088	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	153088	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	137651358	156589	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4075162	156589	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
	162656082	180110	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4755578	180110	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	90405673	177426	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	3	6.0	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmc.2019.115263
	CHEMBL4646553	177426	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	3	6.0	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmc.2019.115263
	90417978	161423	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4159180	161423	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	137645249	157057	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4080998	157057	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	743974	112515	66	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	112515	66	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	81762207	182155	1	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	266	3	2	3	2.2	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F	10.1016/j.bmcl.2020.127650
	CHEMBL4790052	182155	1	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	266	3	2	3	2.2	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F	10.1016/j.bmcl.2020.127650
	137649555	156776	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4077507	156776	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	137656733	159025	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4102951	159025	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	66562388	89929	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386367	89929	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	73777063	1128	34	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	1128	34	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	1128	34	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	85470884	163441	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	163441	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137637713	155303	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4060171	155303	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	134133355	142992	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3898962	142992	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137633536	155742	0	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	155742	0	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	73777069	142125	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	142125	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	85472618	161748	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4164509	161748	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	156016929	177141	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
	CHEMBL4642324	177141	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
	137659366	158872	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4101071	158872	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
	137638317	156169	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
	CHEMBL4070273	156169	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
	137638318	156181	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4070359	156181	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	127031001	138590	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786972	138590	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	137651153	156650	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4076004	156650	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	67072752	86088	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
	CHEMBL2315528	86088	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
	137654131	158456	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4096579	158456	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	134131620	141888	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890035	141888	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	66562286	89921	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	CHEMBL2386359	89921	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	134153298	151822	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3970166	151822	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134131874	144312	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3909773	144312	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	85472227	161627	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162566	161627	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	66562389	89922	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	CHEMBL2386360	89922	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	134156455	153775	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3986721	153775	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	137637713	155303	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4060171	155303	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	25149901	186094	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
	CHEMBL488384	186094	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
	25149901	186094	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL488384	186094	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	85472225	162199	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	162199	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	16775835	179573	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	316	3	2	3	3.1	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4748982	179573	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	316	3	2	3	3.1	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134152336	152910	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3979448	152910	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	16770747	181579	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	334	3	2	3	3.2	Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4782622	181579	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	334	3	2	3	3.2	Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134145700	148207	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3940429	148207	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137656733	159025	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4102951	159025	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	90418333	162093	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169851	162093	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	71655226	89919	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
	CHEMBL2386357	89919	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
	73777174	149909	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	149909	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	6483	3811	49	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	66553168	3811	49	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	CHEMBL2386353	3811	49	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	66562386	89925	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386363	89925	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	127033020	138533	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786418	138533	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	162652317	179731	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4751137	179731	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	162672935	182610	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	7	1	4	3.2	COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4795858	182610	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	7	1	4	3.2	COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	85472359	161568	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161536	161568	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	85472487	161915	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4167097	161915	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	145960576	161591	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161929	161591	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	137637243	155336	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4060517	155336	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	134135468	143930	0	None	-	0	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	143930	0	None	-	0	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	233085	112511	43	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311302	112511	43	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	233085	112511	43	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311302	112511	43	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	233085	112511	43	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311302	112511	43	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012

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Main reference

Ligand source activities (1 row/activity)