Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
2924 1602 37 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
44398069 1602 37 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
9908268 1602 37 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
CHEMBL114606 1602 37 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
11452022 3526 33 None -26 6 Human 9.2 pEC50 = 9.2 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm050242f
6996 3526 33 None -26 6 Human 9.2 pEC50 = 9.2 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm050242f
CHEMBL366208 3526 33 None -26 6 Human 9.2 pEC50 = 9.2 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm050242f
11222939 67218 6 None -12 4 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
44438254 67218 6 None -12 4 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL190006 67218 6 None -12 4 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
10904818 300 0 None -1 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 10.1016/j.bmcl.2005.09.038
2937 300 0 None -1 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 10.1016/j.bmcl.2005.09.038
CHEMBL382739 300 0 None -1 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 10.1016/j.bmcl.2005.09.038
44406004 72355 8 None -7 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 337 14 4 4 2.9 CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
CHEMBL199791 72355 8 None -7 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 337 14 4 4 2.9 CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
11452022 3526 33 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.8b01695
6996 3526 33 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.8b01695
CHEMBL366208 3526 33 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.8b01695
2924 1602 37 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
44398069 1602 37 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
9908268 1602 37 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
CHEMBL114606 1602 37 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
11177439 67535 0 None 239 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 413 7 4 3 3.6 N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O 10.1016/j.bmcl.2011.09.049
CHEMBL1910654 67535 0 None 239 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 413 7 4 3 3.6 N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O 10.1016/j.bmcl.2011.09.049
118877584 181861 0 None -15 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 411 9 3 4 3.7 CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
CHEMBL4786296 181861 0 None -15 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 411 9 3 4 3.7 CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
78321974 139771 0 None -38 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acsmedchemlett.5b00448
CHEMBL3806205 139771 0 None -38 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acsmedchemlett.5b00448
78321974 139771 0 None -38 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
CHEMBL3806205 139771 0 None -38 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
78321974 139771 0 None -38 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
CHEMBL3806205 139771 0 None -38 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
46224767 197608 0 None -14 4 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL590383 197608 0 None -14 4 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
46224768 197609 0 None -5 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL590384 197609 0 None -5 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
136042187 67562 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 347 2 1 4 3.6 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccc(F)cc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
CHEMBL1910799 67562 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 347 2 1 4 3.6 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccc(F)cc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
57395471 67563 0 None 7 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 389 4 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910800 67563 0 None 7 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 389 4 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
45377662 83688 0 None -354 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptorAgonist activity at S1P4 receptor
ChEMBL 468 9 1 6 4.3 CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 10.1016/j.bmcl.2012.09.110
CHEMBL2207778 83688 0 None -354 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptorAgonist activity at S1P4 receptor
ChEMBL 468 9 1 6 4.3 CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 10.1016/j.bmcl.2012.09.110
11224984 8614 18 None -218 4 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
CHEMBL1095833 8614 18 None -218 4 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
4097071 35653 10 None -1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 400 5 0 5 5.1 COc1cccc(C2CN(c3ccc(F)cc3F)N=C2c2cccs2)c1OC nan
CHEMBL1442207 35653 10 None -1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 400 5 0 5 5.1 COc1cccc(C2CN(c3ccc(F)cc3F)N=C2c2cccs2)c1OC nan
46224715 197568 0 None -10 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 371 3 1 5 2.5 Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL590135 197568 0 None -10 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 371 3 1 5 2.5 Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
135656247 72246 6 None 7 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 277 2 3 5 1.1 C/C(=N/NC(N)=S)c1cc2ccc(O)cc2oc1=O nan
CHEMBL1993778 72246 6 None 7 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 277 2 3 5 1.1 C/C(=N/NC(N)=S)c1cc2ccc(O)cc2oc1=O nan
71450073 82163 0 None -354 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayAgonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assay
ChEMBL 585 10 2 5 5.5 Cc1cc(S(=O)(=O)Nc2cccc(-c3cc(C)c(C(=O)N(C)[C@@H](CCN(C)C)C(=O)O)c(C)c3)c2)c(C)cc1Cl 10.1021/jm3009508
CHEMBL2178814 82163 0 None -354 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayAgonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assay
ChEMBL 585 10 2 5 5.5 Cc1cc(S(=O)(=O)Nc2cccc(-c3cc(C)c(C(=O)N(C)[C@@H](CCN(C)C)C(=O)O)c(C)c3)c2)c(C)cc1Cl 10.1021/jm3009508
44342175 85081 0 None -4 4 Human 6.9 pEC50 = 6.9 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL227371 85081 0 None -4 4 Human 6.9 pEC50 = 6.9 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL422074 85081 0 None -4 4 Human 6.9 pEC50 = 6.9 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
46866185 7236 0 None -6 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 321 12 2 3 4.2 CCCCCCCOc1ccc(CC[C@](C)(N)CC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1086172 7236 0 None -6 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 321 12 2 3 4.2 CCCCCCCOc1ccc(CC[C@](C)(N)CC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
44620893 59318 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 361 7 0 4 4.6 COCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
CHEMBL1720965 59318 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 361 7 0 4 4.6 COCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
67194420 142468 0 None -23988 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 468 8 2 8 3.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N nan
CHEMBL3894716 142468 0 None -23988 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 468 8 2 8 3.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N nan
3122786 28220 18 None -4 4 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 334 4 0 4 5.1 COc1ccc(C2CC(c3cccs3)=NN2c2ccccc2)cc1 nan
CHEMBL1375375 28220 18 None -4 4 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 334 4 0 4 5.1 COc1ccc(C2CC(c3cccs3)=NN2c2ccccc2)cc1 nan
10883396 3579 39 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
5283560 3579 39 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
911 3579 39 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
CHEMBL225155 3579 39 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
57398735 69410 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 341 6 0 4 4.7 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])c1 10.1016/j.bmcl.2011.10.096
CHEMBL1935689 69410 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 341 6 0 4 4.7 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])c1 10.1016/j.bmcl.2011.10.096
57396983 69415 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 361 5 0 3 4.6 Clc1ccc(OCCOc2cccnc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1935698 69415 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 361 5 0 3 4.6 Clc1ccc(OCCOc2cccnc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
44517795 67944 0 None -1318 5 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 472 6 1 7 3.9 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)CCN4C(=O)CCC(=O)O)no2)c1 10.1016/j.bmcl.2011.05.110
CHEMBL1916399 67944 0 None -1318 5 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 472 6 1 7 3.9 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)CCN4C(=O)CCC(=O)O)no2)c1 10.1016/j.bmcl.2011.05.110
11222939 67218 6 None -12 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.02.006
44438254 67218 6 None -12 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.02.006
CHEMBL190006 67218 6 None -12 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.02.006
46866186 7235 0 None -3 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 307 11 2 3 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)C(=O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1086171 7235 0 None -3 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 307 11 2 3 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)C(=O)O)cc1 10.1016/j.bmcl.2010.01.118
16196418 50998 1 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 448 10 3 5 3.2 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccccc1)C(=O)OCc1ccccc1 nan
CHEMBL1580856 50998 1 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 448 10 3 5 3.2 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccccc1)C(=O)OCc1ccccc1 nan
44422605 85135 0 None -4 3 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL228103 85135 0 None -4 3 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
57398998 67555 0 None -3 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910691 67555 0 None -3 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
46884020 8340 0 None -89 4 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 397 11 3 3 4.5 CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
CHEMBL1093686 8340 0 None -89 4 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 397 11 3 3 4.5 CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
44422606 85133 0 None -3 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL228049 85133 0 None -3 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
57402269 69061 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 347 6 1 4 4.0 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933157 69061 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 347 6 1 4 4.0 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
3536865 46758 6 None - 1 Human 5.8 pEC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
CHEMBL1541924 46758 6 None - 1 Human 5.8 pEC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
124221654 1100 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
Activation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISAActivation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISA
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
9495 1100 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
Activation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISAActivation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISA
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
CHEMBL3884038 1100 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
Activation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISAActivation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISA
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
44438259 93381 0 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
44438260 93381 0 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL247699 93381 0 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
44547414 67986 0 None -123 6 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 499 5 1 5 5.2 O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21 10.1016/j.bmcl.2011.05.110
CHEMBL1916559 67986 0 None -123 6 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 499 5 1 5 5.2 O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21 10.1016/j.bmcl.2011.05.110
57398995 67542 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3cccc(F)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910673 67542 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3cccc(F)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
58344526 149583 2 None -10232 5 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCO)no2)cc1C#N nan
CHEMBL3951270 149583 2 None -10232 5 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCO)no2)cc1C#N nan
4780551 25163 8 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1349615 25163 8 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
4780551 25163 8 None - 1 Human 6.8 pEC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1349615 25163 8 None - 1 Human 6.8 pEC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
10883396 3579 39 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
5283560 3579 39 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
911 3579 39 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
CHEMBL225155 3579 39 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
44422604 85009 0 None -81 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 432 15 4 4 4.4 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CC(F)OP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL226612 85009 0 None -81 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 432 15 4 4 4.4 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CC(F)OP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
49835990 67559 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CCOC 10.1016/j.bmcl.2011.09.049
CHEMBL1910791 67559 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CCOC 10.1016/j.bmcl.2011.09.049
46881912 6673 0 None -3 4 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 425 13 2 5 2.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCN2CC(=O)NS2(=O)=O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1083841 6673 0 None -3 4 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 425 13 2 5 2.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCN2CC(=O)NS2(=O)=O)cc1 10.1016/j.bmcl.2010.01.118
11222939 67218 6 None -12 4 Human 7.7 pEC50 = 7.7 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
44438254 67218 6 None -12 4 Human 7.7 pEC50 = 7.7 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL190006 67218 6 None -12 4 Human 7.7 pEC50 = 7.7 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
57397318 67548 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 326 2 0 5 3.0 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccn3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910682 67548 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 326 2 0 5 3.0 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccn3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57393539 69062 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 345 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933158 69062 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 345 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
5398663 45568 20 None 1 3 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 285 3 2 5 2.0 O=C(NCc1ccco1)c1cc2ccc(O)cc2oc1=O nan
CHEMBL1531320 45568 20 None 1 3 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 285 3 2 5 2.0 O=C(NCc1ccco1)c1cc2ccc(O)cc2oc1=O nan
5392139 45493 63 None 2 2 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 204 1 1 4 1.7 CC(=O)c1cc2ccc(O)cc2oc1=O nan
CHEMBL153064 45493 63 None 2 2 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 204 1 1 4 1.7 CC(=O)c1cc2ccc(O)cc2oc1=O nan
46881875 7234 0 None 1 4 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 371 13 3 3 4.3 CCCCCCCOc1ccc(CC[C@](C)(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1086170 7234 0 None 1 4 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 371 13 3 3 4.3 CCCCCCCOc1ccc(CC[C@](C)(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
44406749 74671 0 None -1 3 Human 7.7 pEC50 = 7.7 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 565 18 4 10 4.7 C[C@@](N)(CCc1ccc(OCCCCCCCCNc2ccc([N+](=O)[O-])c3nonc23)cc1)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
CHEMBL203475 74671 0 None -1 3 Human 7.7 pEC50 = 7.7 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 565 18 4 10 4.7 C[C@@](N)(CCc1ccc(OCCCCCCCCNc2ccc([N+](=O)[O-])c3nonc23)cc1)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
11452022 3526 33 None -26 6 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazineAgonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazine
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm200609t
6996 3526 33 None -26 6 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazineAgonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazine
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm200609t
CHEMBL366208 3526 33 None -26 6 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazineAgonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazine
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm200609t
2924 1602 37 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
44398069 1602 37 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
9908268 1602 37 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
CHEMBL114606 1602 37 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
1776080 67536 7 None 3 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910655 67536 7 None 3 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
3879894 46986 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
CHEMBL1543937 46986 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
57393538 69056 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 379 5 0 3 4.7 Fc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933150 69056 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 379 5 0 3 4.7 Fc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
57392027 67545 0 None 21 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 361 2 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910678 67545 0 None 21 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 361 2 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
136042189 67539 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 392 3 1 5 4.5 Cc1cc(/C=C2\S/C(=N\c3ccccn3)NC2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
CHEMBL1910660 67539 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 392 3 1 5 4.5 Cc1cc(/C=C2\S/C(=N\c3ccccn3)NC2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
57398795 69060 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933156 69060 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
44620887 59162 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 326 5 0 4 4.2 Cc1ccc(OCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1714368 59162 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 326 5 0 4 4.2 Cc1ccc(OCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
11452022 3526 33 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.0c00631
6996 3526 33 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.0c00631
CHEMBL366208 3526 33 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.0c00631
11452022 3526 33 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2010.02.006
6996 3526 33 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2010.02.006
CHEMBL366208 3526 33 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2010.02.006
57403951 69402 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Br)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935674 69402 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Br)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
44422601 85141 0 None -63 5 Human 6.6 pEC50 = 6.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 398 14 4 3 4.2 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL228139 85141 0 None -63 5 Human 6.6 pEC50 = 6.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 398 14 4 3 4.2 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
44422573 85117 0 None -85 4 Human 5.6 pEC50 = 5.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL227851 85117 0 None -85 4 Human 5.6 pEC50 = 5.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
33291425 69401 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Cl)cc2Br)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935673 69401 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Cl)cc2Br)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
3879894 46986 6 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
CHEMBL1543937 46986 6 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
42630194 75410 0 None -208 5 Human 6.6 pEC50 = 6.6 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
CHEMBL2048287 75410 0 None -208 5 Human 6.6 pEC50 = 6.6 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
49835930 67540 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 371 4 0 4 4.5 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910662 67540 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 371 4 0 4 4.5 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
3536865 46758 6 None - 1 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
CHEMBL1541924 46758 6 None - 1 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
9550812 24298 9 None 2 3 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1ccccc1-n1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
CHEMBL1342332 24298 9 None 2 3 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1ccccc1-n1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
57403952 69405 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(F)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935678 69405 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(F)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
57393480 69413 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 311 5 0 3 4.5 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(C)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935696 69413 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 311 5 0 3 4.5 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(C)n1 10.1016/j.bmcl.2011.10.096
57390239 67551 0 None -1 4 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 339 3 0 4 3.7 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910687 67551 0 None -1 4 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 339 3 0 4 3.7 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57400709 67538 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 3 0 4 5.5 Cc1cc(/C=C2\S/C(=N\c3ccccc3)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
CHEMBL1910658 67538 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 3 0 4 5.5 Cc1cc(/C=C2\S/C(=N\c3ccccc3)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
57395199 69406 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 337 7 0 7 2.8 Cc1ccc(OCCOc2ccc([N+](=O)[O-])cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935680 69406 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 337 7 0 7 2.8 Cc1ccc(OCCOc2ccc([N+](=O)[O-])cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
57395254 69059 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 6 1 4 3.9 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933155 69059 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 6 1 4 3.9 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
16193872 28248 9 None 3 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 348 1 0 6 2.5 N#Cc1cc2c(=O)n3ccccc3nc2n(-c2ccccc2Cl)c1=O nan
CHEMBL1375597 28248 9 None 3 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 348 1 0 6 2.5 N#Cc1cc2c(=O)n3ccccc3nc2n(-c2ccccc2Cl)c1=O nan
44620883 59503 2 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1728130 59503 2 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
44620883 59503 2 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl nan
CHEMBL1728130 59503 2 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl nan
118877433 176756 0 None -14 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 459 8 3 4 4.5 COc1ccccc1CC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
CHEMBL4637401 176756 0 None -14 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 459 8 3 4 4.5 COc1ccccc1CC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
59384375 103898 0 None -8 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 510 13 3 6 5.9 CCCCCCCCOc1ccc(-c2cnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
CHEMBL3102903 103898 0 None -8 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 510 13 3 6 5.9 CCCCCCCCOc1ccc(-c2cnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
57400397 69411 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 362 6 0 5 4.4 O=[N+]([O-])c1nc(Cl)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1935690 69411 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 362 6 0 5 4.4 O=[N+]([O-])c1nc(Cl)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
57397316 67541 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 373 4 1 5 3.1 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
CHEMBL1910663 67541 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 373 4 1 5 3.1 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
57392028 67549 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 344 2 0 5 3.2 C/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910685 67549 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 344 2 0 5 3.2 C/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57395198 69404 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Cl)cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935677 69404 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Cl)cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
57397321 67554 0 None -17 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 403 5 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910690 67554 0 None -17 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 403 5 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
57400712 67544 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 368 2 0 5 3.6 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)c(C#N)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910675 67544 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 368 2 0 5 3.6 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)c(C#N)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
2063413 25425 29 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 256 2 0 4 3.1 N#Cc1c(-n2cccc2C=O)sc2c1CCCC2 nan
CHEMBL1351890 25425 29 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 256 2 0 4 3.1 N#Cc1c(-n2cccc2C=O)sc2c1CCCC2 nan
25110406 1265 47 None -1698 4 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 409 9 2 7 3.8 OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC nan
2928 1265 47 None -1698 4 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 409 9 2 7 3.8 OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC nan
CHEMBL3922179 1265 47 None -1698 4 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 409 9 2 7 3.8 OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC nan
44438261 93414 0 None -1 2 Human 7.5 pEC50 = 7.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
44438262 93414 0 None -1 2 Human 7.5 pEC50 = 7.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL247901 93414 0 None -1 2 Human 7.5 pEC50 = 7.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
2864688 36189 9 None -3 5 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 473 4 1 4 4.6 NS(=O)(=O)c1ccc(N2N=C(c3ccc(Br)cc3)CC2c2ccc(F)cc2)cc1 nan
CHEMBL1447076 36189 9 None -3 5 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 473 4 1 4 4.6 NS(=O)(=O)c1ccc(N2N=C(c3ccc(Br)cc3)CC2c2ccc(F)cc2)cc1 nan
44422579 85140 0 None -11 3 Human 6.5 pEC50 = 6.5 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 356 13 4 3 3.9 CCCCCCCCc1cccc(NC[C@H](N)CCP(=O)(O)O)c1 10.1016/j.bmc.2006.10.060
CHEMBL228138 85140 0 None -11 3 Human 6.5 pEC50 = 6.5 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 356 13 4 3 3.9 CCCCCCCCc1cccc(NC[C@H](N)CCP(=O)(O)O)c1 10.1016/j.bmc.2006.10.060
44438257 93380 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
44438258 93380 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL247698 93380 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
57391736 69407 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 353 7 0 7 3.3 Cc1ccc(OCCOc2cc(Cl)cc([N+](=O)[O-])c2)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935681 69407 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 353 7 0 7 3.3 Cc1ccc(OCCOc2cc(Cl)cc([N+](=O)[O-])c2)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
136212602 11633 7 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
44394498 11633 7 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
CHEMBL1181619 11633 7 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
CHEMBL1910653 11633 7 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
136042188 67537 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 329 2 1 4 3.4 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccccc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
CHEMBL1910656 67537 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 329 2 1 4 3.4 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccccc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
3418421 58958 7 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 355 5 1 5 3.6 Cc1ccc(OCC(=O)Nc2cc(Cl)cc(Cl)c2)c([N+](=O)[O-])n1 nan
CHEMBL1704790 58958 7 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 355 5 1 5 3.6 Cc1ccc(OCC(=O)Nc2cc(Cl)cc(Cl)c2)c([N+](=O)[O-])n1 nan
3093171 45803 12 None -1 4 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 423 8 2 6 1.9 O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO nan
CHEMBL1533401 45803 12 None -1 4 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 423 8 2 6 1.9 O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO nan
1522831 37307 18 None -1 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 376 2 0 6 4.3 Cn1c(-c2cc3ccc(OC(=O)C(C)(C)C)cc3oc2=O)nc2ccccc21 nan
CHEMBL1456255 37307 18 None -1 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 376 2 0 6 4.3 Cn1c(-c2cc3ccc(OC(=O)C(C)(C)C)cc3oc2=O)nc2ccccc21 nan
665934 42481 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 335 1 0 8 1.6 Cc1ccc2nc3c(cc(C#N)c(=O)n3-c3nccs3)c(=O)n2c1 nan
CHEMBL1501839 42481 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 335 1 0 8 1.6 Cc1ccc2nc3c(cc(C#N)c(=O)n3-c3nccs3)c(=O)n2c1 nan
136042186 67561 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 316 2 1 5 2.5 C/N=C1/NC(=O)/C(=C/c2cnn(-c3ccc(F)cc3)c2C)S1 10.1016/j.bmcl.2011.09.049
CHEMBL1910794 67561 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 316 2 1 5 2.5 C/N=C1/NC(=O)/C(=C/c2cnn(-c3ccc(F)cc3)c2C)S1 10.1016/j.bmcl.2011.09.049
44620884 59374 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1723135 59374 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 10.1016/j.bmcl.2011.10.096
44620884 59374 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 nan
CHEMBL1723135 59374 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 nan
57390242 67564 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 5 1 5 3.0 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1Cc1ccccc1 10.1016/j.bmcl.2011.09.049
CHEMBL1910801 67564 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 5 1 5 3.0 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1Cc1ccccc1 10.1016/j.bmcl.2011.09.049
2924 1602 37 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
44398069 1602 37 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
9908268 1602 37 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
CHEMBL114606 1602 37 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
59384310 103899 0 None -17 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 511 13 3 7 5.2 CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
CHEMBL3102904 103899 0 None -17 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 511 13 3 7 5.2 CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
9550767 24160 9 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1cccc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)c1 nan
CHEMBL1341200 24160 9 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1cccc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)c1 nan
25192001 7961 0 None -9 4 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
CHEMBL1091103 7961 0 None -9 4 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
52938427 2924 47 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
5383 2924 47 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
8709 2924 47 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
CHEMBL3707247 2924 47 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
DB12612 2924 47 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
57398996 67543 1 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910674 67543 1 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
1132552 46214 6 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 357 3 1 5 4.0 COc1ccc(-c2c(C#N)c(N)nc3c2CCc2ccccc2-3)cc1OC nan
CHEMBL1537481 46214 6 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 357 3 1 5 4.0 COc1ccc(-c2c(C#N)c(N)nc3c2CCc2ccccc2-3)cc1OC nan
57390238 67546 0 None 6 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 377 2 0 4 4.4 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(Cl)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910680 67546 0 None 6 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 377 2 0 4 4.4 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(Cl)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
5296049 50561 12 None -1 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 304 2 1 1 5.5 Clc1ccc(/C=C\c2[nH]ccc3c4ccccc4nc2-3)cc1 nan
CHEMBL1577139 50561 12 None -1 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 304 2 1 1 5.5 Clc1ccc(/C=C\c2[nH]ccc3c4ccccc4nc2-3)cc1 nan
665938 26504 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 319 1 0 8 1.2 Cc1cc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)no1 nan
CHEMBL1362307 26504 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 319 1 0 8 1.2 Cc1cc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)no1 nan
44620894 59305 23 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1720563 59305 23 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
44620894 59305 23 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
CHEMBL1720563 59305 23 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
44620892 59621 22 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1732549 59621 22 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
44620892 59621 22 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 nan
CHEMBL1732549 59621 22 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 nan
42630194 75410 0 None -208 5 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
CHEMBL2048287 75410 0 None -208 5 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
57402197 69412 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 355 6 0 5 3.9 COC(=O)c1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1935691 69412 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 355 6 0 5 3.9 COC(=O)c1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
4300117 26668 6 None - 1 Human 4.3 pEC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 392 6 2 6 2.3 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2)c1Cl nan
CHEMBL1363676 26668 6 None - 1 Human 4.3 pEC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 392 6 2 6 2.3 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2)c1Cl nan
25192001 7961 0 None -9 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
CHEMBL1091103 7961 0 None -9 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
118877603 179838 0 None -6 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 425 10 3 4 4.1 COCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
CHEMBL4752394 179838 0 None -6 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 425 10 3 4 4.1 COCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
46881847 6965 0 None -6 4 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1084929 6965 0 None -6 4 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
11588811 3937 39 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
136212600 3937 39 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
3324 3937 39 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
CHEMBL228102 3937 39 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
44620895 59345 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1722064 59345 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
44620895 59345 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 nan
CHEMBL1722064 59345 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 nan
16196388 53516 0 None 4 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 372 8 3 5 1.7 CNC(=O)c1[nH]cnc1C(=O)N[C@@H](CC(C)C)C(=O)OCc1ccccc1 nan
CHEMBL1604216 53516 0 None 4 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 372 8 3 5 1.7 CNC(=O)c1[nH]cnc1C(=O)N[C@@H](CC(C)C)C(=O)OCc1ccccc1 nan
4780551 25163 8 None - 1 Human 6.3 pEC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1349615 25163 8 None - 1 Human 6.3 pEC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
56835136 69057 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 423 5 0 3 4.8 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933151 69057 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 423 5 0 3 4.8 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
57397319 67550 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 372 4 0 5 3.9 CC/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910686 67550 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 372 4 0 5 3.9 CC/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
57402195 69403 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1cc(Cl)ccc1OCCOc1ccc(C)nc1[N+](=O)[O-] 10.1016/j.bmcl.2011.10.096
CHEMBL1935675 69403 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1cc(Cl)ccc1OCCOc1ccc(C)nc1[N+](=O)[O-] 10.1016/j.bmcl.2011.10.096
25110382 145564 0 None -34673 5 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 366 6 1 6 4.2 CCOc1ccc(-c2nc(-c3cccc4c3CCC4O)no2)cc1OCC nan
CHEMBL3919445 145564 0 None -34673 5 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 366 6 1 6 4.2 CCOc1ccc(-c2nc(-c3cccc4c3CCC4O)no2)cc1OCC nan
10311 1262 34 None 37 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 10.1016/j.bmcl.2011.09.049
49835928 1262 34 None 37 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910803 1262 34 None 37 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 10.1016/j.bmcl.2011.09.049
46224769 199148 0 None -281 4 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 331 2 1 3 4.3 Cc1nn(C(=O)/C=C/c2cccc3[nH]ccc23)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL601062 199148 0 None -281 4 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 331 2 1 3 4.3 Cc1nn(C(=O)/C=C/c2cccc3[nH]ccc23)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
44620882 59378 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1723233 59378 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
44620882 59378 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1723233 59378 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
647592 33196 17 None -1 4 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 401 5 2 6 2.7 CC(C)n1c(=N)c(C(=O)NCCc2ccccc2)cc2c(=O)n3ccccc3nc21 nan
CHEMBL1419836 33196 17 None -1 4 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 401 5 2 6 2.7 CC(C)n1c(=N)c(C(=O)NCCc2ccccc2)cc2c(=O)n3ccccc3nc21 nan
11977938 70551 24 None -38 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human S1P4 receptorAgonist activity at human S1P4 receptor
ChEMBL 461 8 1 7 5.3 CCc1cc(CN2CC(C(=O)O)C2)sc1-c1noc(-c2ccc(Oc3ccccc3)cc2)n1 10.1016/j.ejmech.2012.02.022
CHEMBL1951304 70551 24 None -38 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human S1P4 receptorAgonist activity at human S1P4 receptor
ChEMBL 461 8 1 7 5.3 CCc1cc(CN2CC(C(=O)O)C2)sc1-c1noc(-c2ccc(Oc3ccccc3)cc2)n1 10.1016/j.ejmech.2012.02.022
57398794 69058 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 3 6.3 Clc1ccc(OCCOc2ccc(-c3ccccc3)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1933153 69058 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 3 6.3 Clc1ccc(OCCOc2ccc(-c3ccccc3)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
57396981 69408 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 420 6 0 5 4.5 Cc1ccc(OCCOc2ccc(Br)cc2C(F)(F)F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935682 69408 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 420 6 0 5 4.5 Cc1ccc(OCCOc2ccc(Br)cc2C(F)(F)F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
49835989 67547 1 None -8 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 4.4 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910681 67547 1 None -8 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 4.4 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
11545181 3940 4 None -229 3 Human 5.2 pEC50 = 5.2 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
2930 3940 4 None -229 3 Human 5.2 pEC50 = 5.2 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
CHEMBL389033 3940 4 None -229 3 Human 5.2 pEC50 = 5.2 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
3239161 19452 11 None 3 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 278 2 0 6 1.1 C=CCn1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
CHEMBL1300662 19452 11 None 3 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 278 2 0 6 1.1 C=CCn1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
44406009 72349 0 None -12 4 Human 7.2 pEC50 = 7.2 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 515 18 5 10 3.4 N[C@@H](COP(=O)(O)O)[C@H](O)/C=C/CCCCCCCCCCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/j.bmcl.2005.09.038
CHEMBL199754 72349 0 None -12 4 Human 7.2 pEC50 = 7.2 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 515 18 5 10 3.4 N[C@@H](COP(=O)(O)O)[C@H](O)/C=C/CCCCCCCCCCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/j.bmcl.2005.09.038
57400467 69063 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 343 6 0 3 5.1 C=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933159 69063 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 343 6 0 3 5.1 C=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
57398999 67556 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(CCc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910692 67556 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(CCc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
46881877 7011 0 None 1 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 359 13 2 5 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCc2nnn[nH]2)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1085191 7011 0 None 1 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 359 13 2 5 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCc2nnn[nH]2)cc1 10.1016/j.bmcl.2010.01.118
57390243 67565 0 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 383 6 0 5 3.7 COCC/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910802 67565 0 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 383 6 0 5 3.7 COCC/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
16215109 146963 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
44438256 146963 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL393055 146963 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
16215109 146963 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2011.09.049
44438256 146963 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2011.09.049
CHEMBL393055 146963 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2011.09.049
10883396 3579 39 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
5283560 3579 39 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
911 3579 39 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
CHEMBL225155 3579 39 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
57397320 67552 0 None -1 3 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 357 3 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910688 67552 0 None -1 3 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 357 3 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
44620886 59088 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1710229 59088 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 10.1016/j.bmcl.2011.10.096
44620886 59088 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 nan
CHEMBL1710229 59088 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 nan
57393481 69414 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 325 6 0 3 4.7 CCc1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1935697 69414 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 325 6 0 3 4.7 CCc1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
58344692 144377 0 None -7413 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 459 5 2 7 3.4 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NC(=O)N3CC(O)C3)no2)cc1C#N nan
CHEMBL3910269 144377 0 None -7413 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 459 5 2 7 3.4 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NC(=O)N3CC(O)C3)no2)cc1C#N nan
44599207 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
5326 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
9289 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
CHEMBL2336071 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
DB12371 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
135502886 121149 23 None -1 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 221 1 2 4 1.1 NC(=S)c1cc2ccc(O)cc2oc1=O nan
CHEMBL358644 121149 23 None -1 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 221 1 2 4 1.1 NC(=S)c1cc2ccc(O)cc2oc1=O nan
733831 32011 10 None 2 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 4 0 7 2.8 CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O nan
CHEMBL1409828 32011 10 None 2 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 4 0 7 2.8 CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O nan
52938426 3312 8 None -34673 5 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N nan
9889 3312 8 None -34673 5 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N nan
CHEMBL3899384 3312 8 None -34673 5 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N nan
11222939 67218 6 None -12 4 Human 7.1 pEC50 = 7.1 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1021/jm050242f
44438254 67218 6 None -12 4 Human 7.1 pEC50 = 7.1 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1021/jm050242f
CHEMBL190006 67218 6 None -12 4 Human 7.1 pEC50 = 7.1 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1021/jm050242f
46881876 5510 0 None -3 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 335 13 2 3 4.6 CCCCCCCOc1ccc(CC[C@](C)(N)CCC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1077288 5510 0 None -3 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 335 13 2 3 4.6 CCCCCCCOc1ccc(CC[C@](C)(N)CCC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
1776080 107635 7 None 1 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 343 2 0 4 3.8 C/N=C1/S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C nan
CHEMBL3195883 107635 7 None 1 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 343 2 0 4 3.8 C/N=C1/S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C nan
2891826 53654 10 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 362 5 0 5 4.9 COc1ccc(C2CC(c3cccs3)=NN2c2ccc(C=O)cc2)cc1 nan
CHEMBL1605463 53654 10 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 362 5 0 5 4.9 COc1ccc(C2CC(c3cccs3)=NN2c2ccc(C=O)cc2)cc1 nan
90660718 59654 0 None 1 3 Human 7.1 pEC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 391 4 0 5 3.9 C/N=C1\S/C(=C/c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1OC nan
CHEMBL1734070 59654 0 None 1 3 Human 7.1 pEC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 391 4 0 5 3.9 C/N=C1\S/C(=C/c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1OC nan
16196416 29293 1 None - 1 Human 4.0 pEC50 = 4.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 482 10 3 5 3.4 O=C(NCc1ccccc1)c1nc[nH]c1C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 nan
CHEMBL1384911 29293 1 None - 1 Human 4.0 pEC50 = 4.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 482 10 3 5 3.4 O=C(NCc1ccccc1)c1nc[nH]c1C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 nan
58344778 153988 0 None -53703 5 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N nan
CHEMBL3902160 153988 0 None -53703 5 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N nan
CHEMBL3990889 153988 0 None -53703 5 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N nan
57400714 67553 0 None -2 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910689 67553 0 None -2 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57400396 69409 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 340 6 0 4 4.6 Cc1ccc(OCCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935683 69409 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 340 6 0 4 4.6 Cc1ccc(OCCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
2842931 46274 14 None -3 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 3 0 4 5.4 Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1 nan
CHEMBL1537907 46274 14 None -3 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 3 0 4 5.4 Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1 nan
664390 31208 11 None 2 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 447 5 2 7 2.4 N=c1c(C(=O)NCc2ccc(F)cc2)cc2c(=O)n3ccccc3nc2n1CC1CCCO1 nan
CHEMBL1402796 31208 11 None 2 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 447 5 2 7 2.4 N=c1c(C(=O)NCc2ccc(F)cc2)cc2c(=O)n3ccccc3nc2n1CC1CCCO1 nan
67001 48925 22 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 321 5 1 5 2.4 CCN(c1ccccc1)S(=O)(=O)c1cc([N+](=O)[O-])ccc1N nan
CHEMBL1562579 48925 22 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 321 5 1 5 2.4 CCN(c1ccccc1)S(=O)(=O)c1cc([N+](=O)[O-])ccc1N nan
998879 33921 10 None 18 2 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 371 4 1 7 3.6 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1C nan
CHEMBL1425921 33921 10 None 18 2 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 371 4 1 7 3.6 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1C nan
2767048 23256 11 None 6 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL1333510 23256 11 None 6 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
2330223 45322 6 None 5 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
CHEMBL1529115 45322 6 None 5 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
44607577 43630 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1511839 43630 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607577 43630 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1511839 43630 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
998685 33787 14 None 7 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 357 4 1 7 3.3 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1 nan
CHEMBL1424697 33787 14 None 7 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 357 4 1 7 3.3 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1 nan
3838273 46910 13 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
CHEMBL1543295 46910 13 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
4576185 41574 13 None 7 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 413 7 1 9 3.3 COc1ccc(Oc2cc(NC(=O)c3nn(C)cc3[N+](=O)[O-])cc([N+](=O)[O-])c2)cc1 nan
CHEMBL1493442 41574 13 None 7 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 413 7 1 9 3.3 COc1ccc(Oc2cc(NC(=O)c3nn(C)cc3[N+](=O)[O-])cc([N+](=O)[O-])c2)cc1 nan
3236803 41485 8 None 3 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 302 2 0 4 2.6 CS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1492648 41485 8 None 3 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 302 2 0 4 2.6 CS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
655335 32145 4 None 9 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 491 7 1 9 4.0 CC(C)c1nnc(NC(=O)CCS(=O)(=O)c2nc(-c3cccs3)cc(C(F)(F)F)n2)s1 nan
CHEMBL1410897 32145 4 None 9 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 491 7 1 9 4.0 CC(C)c1nnc(NC(=O)CCS(=O)(=O)c2nc(-c3cccs3)cc(C(F)(F)F)n2)s1 nan
2767048 23256 11 None 6 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL1333510 23256 11 None 6 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
1486982 33767 14 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
CHEMBL1424562 33767 14 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
2801235 35340 29 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
CHEMBL1439384 35340 29 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
54581611 62124 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 435 4 1 2 7.8 Cc1cc(-c2ccccc2)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779904 62124 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 435 4 1 2 7.8 Cc1cc(-c2ccccc2)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
54586463 62131 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccs2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779914 62131 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccs2)o1 10.1016/j.bmcl.2011.04.097
883460 54026 6 None 13 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 4 0 3 3.7 CN(c1ccccc1)c1ccc(/C=C/[N+](=O)[O-])cc1 nan
CHEMBL1608392 54026 6 None 13 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 4 0 3 3.7 CN(c1ccccc1)c1ccc(/C=C/[N+](=O)[O-])cc1 nan
663900 24256 8 None 5 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1341981 24256 8 None 5 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
1486982 33767 14 None 3 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
CHEMBL1424562 33767 14 None 3 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
2221997 27083 13 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 3 0 7 0.1 COc1cccc(-n2nnnc2S(C)(=O)=O)c1 nan
CHEMBL1367316 27083 13 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 3 0 7 0.1 COc1cccc(-n2nnnc2S(C)(=O)=O)c1 nan
1474465 24438 22 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 3 0 5 2.7 Cc1ccc(C(=O)OCn2ncc(Cl)c(Cl)c2=O)cc1 nan
CHEMBL1343392 24438 22 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 3 0 5 2.7 Cc1ccc(C(=O)OCn2ncc(Cl)c(Cl)c2=O)cc1 nan
5286934 49021 8 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
CHEMBL1563483 49021 8 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
1336753 29935 14 None 7 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
CHEMBL1390139 29935 14 None 7 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
54584551 62134 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 295 3 0 3 4.4 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccco2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779917 62134 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 295 3 0 3 4.4 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccco2)o1 10.1016/j.bmcl.2011.04.097
900031 42302 11 None 11 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 340 3 0 3 4.5 CC(=O)n1cc(N(C(=O)CCl)c2ccc(C)cc2)c2ccccc21 nan
CHEMBL1500227 42302 11 None 11 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 340 3 0 3 4.5 CC(=O)n1cc(N(C(=O)CCl)c2ccc(C)cc2)c2ccccc21 nan
305322 23175 13 None 2 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 3 0 5 2.5 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1CC1CCCO1 nan
CHEMBL1332881 23175 13 None 2 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 3 0 5 2.5 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1CC1CCCO1 nan
4252324 54609 9 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 7 3 6 1.2 O=C(CCl)Nc1cc(SCC(O)CO)cc([N+](=O)[O-])c1 nan
CHEMBL1613578 54609 9 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 7 3 6 1.2 O=C(CCl)Nc1cc(SCC(O)CO)cc([N+](=O)[O-])c1 nan
2320547 46014 1 None 3 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 0 6 3.0 CN1/C(=C/C(=O)c2nc(S(C)(=O)=O)ncc2Cl)C(C)(C)c2ccccc21 nan
CHEMBL1535546 46014 1 None 3 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 0 6 3.0 CN1/C(=C/C(=O)c2nc(S(C)(=O)=O)ncc2Cl)C(C)(C)c2ccccc21 nan
4019447 19319 7 None 1 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
CHEMBL1299526 19319 7 None 1 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
2035866 27549 10 None 4 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1370681 27549 10 None 4 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
2801236 79763 6 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
CHEMBL213580 79763 6 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
977927 47060 8 None 6 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 283 3 1 3 3.5 CCc1ccc2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
CHEMBL1544423 47060 8 None 6 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 283 3 1 3 3.5 CCc1ccc2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
2585205 53715 8 None 6 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 1 6 2.4 CCOC(=O)c1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1 nan
CHEMBL1605956 53715 8 None 6 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 1 6 2.4 CCOC(=O)c1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1 nan
9660957 72396 11 None 1 5 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
CHEMBL1999049 72396 11 None 1 5 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
2585042 46567 7 None 3 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 480 4 0 6 2.2 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
CHEMBL1540377 46567 7 None 3 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 480 4 0 6 2.2 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
1475337 20516 11 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
CHEMBL1309232 20516 11 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
704848 33207 14 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 2 0 5 3.3 Cc1ccnc(N2C(=O)c3cccc4c([N+](=O)[O-])ccc(c34)C2=O)c1 nan
CHEMBL1419909 33207 14 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 2 0 5 3.3 Cc1ccnc(N2C(=O)c3cccc4c([N+](=O)[O-])ccc(c34)C2=O)c1 nan
1916369 41850 8 None 9 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 5 1 6 2.4 COC(CNC(=O)c1ccc2c3c(onc13)-c1ccccc1C2=O)OC nan
CHEMBL1496231 41850 8 None 9 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 5 1 6 2.4 COC(CNC(=O)c1ccc2c3c(onc13)-c1ccccc1C2=O)OC nan
44607575 52252 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1592119 52252 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607575 52252 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1592119 52252 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
2430298 23717 8 None 2 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 323 2 0 4 2.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCc2ccccc21 nan
CHEMBL1337227 23717 8 None 2 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 323 2 0 4 2.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCc2ccccc21 nan
2980954 29020 8 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 5 1 6 3.4 O=C(Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1)c1ccc([N+](=O)[O-])o1 nan
CHEMBL1382558 29020 8 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 5 1 6 3.4 O=C(Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1)c1ccc([N+](=O)[O-])o1 nan
5680788 72433 2 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 410 4 2 6 3.8 O=C1C(Nc2ccc(O)cc2)=C/C(=N/S(=O)(=O)c2cccs2)c2ccccc21 nan
CHEMBL2000517 72433 2 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 410 4 2 6 3.8 O=C1C(Nc2ccc(O)cc2)=C/C(=N/S(=O)(=O)c2cccs2)c2ccccc21 nan
1114196 39316 5 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1473443 39316 5 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
1114196 39316 5 None - 1 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 nan
CHEMBL1473443 39316 5 None - 1 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 nan
1474489 40499 13 None 1 6 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 404 3 0 5 2.7 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccc(F)cc1 nan
CHEMBL1485010 40499 13 None 1 6 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 404 3 0 5 2.7 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccc(F)cc1 nan
6217704 32352 3 None -7 6 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
CHEMBL1412583 32352 3 None -7 6 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
44607579 43629 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1511831 43629 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607579 43629 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1511831 43629 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
9551645 36524 5 None 4 2 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1449794 36524 5 None 4 2 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
135415440 197362 8 None 4 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
CHEMBL586135 197362 8 None 4 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
5290862 47440 10 None 14 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 7 1 2 4.4 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)C(F)F nan
CHEMBL1547643 47440 10 None 14 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 7 1 2 4.4 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)C(F)F nan
100520 32491 5 None 4 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
CHEMBL1413680 32491 5 None 4 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
56682428 64812 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2cc(C)c(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824257 64812 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2cc(C)c(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
1474487 19851 14 None 1 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 3 0 5 3.2 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccccc1Cl nan
CHEMBL1303810 19851 14 None 1 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 3 0 5 3.2 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccccc1Cl nan
9631442 71812 6 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 3 2 4 3.8 Cc1c(/C=N/Nc2nc3ccccc3[nH]2)c2ccccc2n1C nan
CHEMBL1979747 71812 6 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 3 2 4 3.8 Cc1c(/C=N/Nc2nc3ccccc3[nH]2)c2ccccc2n1C nan
2295300 36173 10 None 3 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
CHEMBL1446971 36173 10 None 3 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
1007755 25804 11 None - 1 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 nan
CHEMBL1354895 25804 11 None - 1 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 nan
5311103 46215 15 None 3 4 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 466 2 2 6 4.4 CN[C@H]1C[C@H]2O[C@@](C)([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 nan
CHEMBL1537489 46215 15 None 3 4 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 466 2 2 6 4.4 CN[C@H]1C[C@H]2O[C@@](C)([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 nan
72813 200594 88 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 1 0 3 2.5 O=c1c(Cl)c(Cl)cnn1-c1ccccc1 nan
CHEMBL610198 200594 88 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 1 0 3 2.5 O=c1c(Cl)c(Cl)cnn1-c1ccccc1 nan
3143422 45332 6 None 6 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 355 5 2 6 3.6 Cc1cc(NC(=O)c2ccc([N+](=O)[O-])o2)ccc1NC(=O)c1ccco1 nan
CHEMBL1529188 45332 6 None 6 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 355 5 2 6 3.6 Cc1cc(NC(=O)c2ccc([N+](=O)[O-])o2)ccc1NC(=O)c1ccco1 nan
2766929 50024 24 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
CHEMBL1572001 50024 24 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
1484340 45791 20 None 1 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.1 O=C1C=C(c2ccc(Cl)cc2)C(=O)N1Nc1ccccc1 nan
CHEMBL1533279 45791 20 None 1 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.1 O=C1C=C(c2ccc(Cl)cc2)C(=O)N1Nc1ccccc1 nan
5290861 54307 14 None 6 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 5 1 2 4.1 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)F nan
CHEMBL1610831 54307 14 None 6 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 5 1 2 4.1 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)F nan
6258408 36210 7 None 3 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 3 1 4 3.4 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1ccccc1 nan
CHEMBL1447306 36210 7 None 3 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 3 1 4 3.4 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1ccccc1 nan
11452022 3526 33 None -26 6 Human 8.7 pIC50 = 8.7 Functional
Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2011.10.088
6996 3526 33 None -26 6 Human 8.7 pIC50 = 8.7 Functional
Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2011.10.088
CHEMBL366208 3526 33 None -26 6 Human 8.7 pIC50 = 8.7 Functional
Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2011.10.088
1363299 32709 10 None 37 5 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1415555 32709 10 None 37 5 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 10.1016/j.bmcl.2011.04.097
5761997 34039 5 None 4 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 0 6 4.2 COc1ccc(C(=O)/C(=C\c2ccco2)N2C=CC=CC2=C(C#N)C#N)cc1 nan
CHEMBL1426792 34039 5 None 4 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 0 6 4.2 COc1ccc(C(=O)/C(=C\c2ccco2)N2C=CC=CC2=C(C#N)C#N)cc1 nan
375895 20650 9 None 3 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 286 2 0 4 2.8 COc1ccc(OC)c2c1C(=O)C(Cl)=C(Cl)C2=O nan
CHEMBL131037 20650 9 None 3 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 286 2 0 4 2.8 COc1ccc(OC)c2c1C(=O)C(Cl)=C(Cl)C2=O nan
6763 190841 99 None 1 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 208 0 0 2 2.7 O=C1C(=O)c2ccccc2-c2ccccc21 nan
CHEMBL51931 190841 99 None 1 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 208 0 0 2 2.7 O=C1C(=O)c2ccccc2-c2ccccc21 nan
282594 45076 15 None 2 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 3 3.7 CC(=O)N(C1=C(Cl)C(=O)c2ccccc2C1=O)C1CCCCC1 nan
CHEMBL1526855 45076 15 None 2 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 3 3.7 CC(=O)N(C1=C(Cl)C(=O)c2ccccc2C1=O)C1CCCCC1 nan
991251 39917 16 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 361 3 1 5 2.9 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc3ccccc3c2)n1 nan
CHEMBL1480031 39917 16 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 361 3 1 5 2.9 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc3ccccc3c2)n1 nan
2769258 43131 20 None 10 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 270 2 0 4 2.5 COc1ccc(-n2ncc(Cl)c(Cl)c2=O)cc1 nan
CHEMBL1507537 43131 20 None 10 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 270 2 0 4 2.5 COc1ccc(-n2ncc(Cl)c(Cl)c2=O)cc1 nan
51000470 62110 0 None 144 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 2 3 5.6 Cc1cc(CO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779890 62110 0 None 144 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 2 3 5.6 Cc1cc(CO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
56662043 64811 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2coc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824256 64811 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2coc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
2585250 28130 7 None 5 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
CHEMBL1374788 28130 7 None 5 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
900971 38824 30 None 3 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 316 3 0 4 3.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)c1ccc(Cl)cc1 nan
CHEMBL1468847 38824 30 None 3 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 316 3 0 4 3.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)c1ccc(Cl)cc1 nan
78545 26813 23 None 15 3 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 204 1 0 3 1.7 Cc1cc([N+](=O)[O-])c2ccccc2[n+]1[O-] nan
CHEMBL1364999 26813 23 None 15 3 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 204 1 0 3 1.7 Cc1cc([N+](=O)[O-])c2ccccc2[n+]1[O-] nan
5187118 51570 7 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
CHEMBL1585527 51570 7 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
1363299 32709 10 None 37 5 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
CHEMBL1415555 32709 10 None 37 5 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
56675824 64810 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)co2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824255 64810 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)co2)c1 10.1016/j.bmcl.2011.06.132
2402478 49432 7 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 429 8 0 7 3.0 CN(CCC#N)C(=O)COC(=O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1566808 49432 7 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 429 8 0 7 3.0 CN(CCC#N)C(=O)COC(=O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
56672438 64815 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 343 3 1 1 6.1 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)ccc2C)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824260 64815 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 343 3 1 1 6.1 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)ccc2C)c1 10.1016/j.bmcl.2011.06.132
3270222 36602 6 None - 1 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
CHEMBL1450393 36602 6 None - 1 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
10312 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2011.04.097
53358422 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2011.04.097
CHEMBL1779732 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2011.04.097
44607574 39249 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1472539 39249 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
37839 190145 24 None 19 3 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 232 2 0 2 2.8 CC1(C)C[C@H]2[C@H](C=C(C=O)[C@]3(C=O)C[C@]23C)C1 nan
CHEMBL518292 190145 24 None 19 3 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 232 2 0 2 2.8 CC1(C)C[C@H]2[C@H](C=C(C=O)[C@]3(C=O)C[C@]23C)C1 nan
44607574 39249 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1472539 39249 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
2328694 53431 2 None 8 5 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
CHEMBL1603615 53431 2 None 8 5 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
665480 26905 4 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 CCC(C)[C@@H](NC(=O)OC(C)(C)C)c1nnc(S(=O)(=O)Cc2cccc(C)c2)o1 nan
CHEMBL1365696 26905 4 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 CCC(C)[C@@H](NC(=O)OC(C)(C)C)c1nnc(S(=O)(=O)Cc2cccc(C)c2)o1 nan
2743870 33660 5 None 4 3 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 285 5 1 9 1.7 C=CCn1c(O)nnc1Sc1ncc([N+](=O)[O-])s1 nan
CHEMBL1423626 33660 5 None 4 3 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 285 5 1 9 1.7 C=CCn1c(O)nnc1Sc1ncc([N+](=O)[O-])s1 nan
54584549 62126 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 339 3 0 2 5.5 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779906 62126 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 339 3 0 2 5.5 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccccc2Cl)o1 10.1016/j.bmcl.2011.04.097
7275219 48008 8 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 339 4 1 2 5.7 CCc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2Cl)o1 nan
CHEMBL1553396 48008 8 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 339 4 1 2 5.7 CCc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2Cl)o1 nan
44607581 30384 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1393993 30384 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
44607581 30384 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 nan
CHEMBL1393993 30384 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 nan
663900 24256 8 None 5 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1341981 24256 8 None 5 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
2452801 24099 7 None 3 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 310 3 0 4 3.1 Cc1ccc(C)c(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c1 nan
CHEMBL1340619 24099 7 None 3 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 310 3 0 4 3.1 Cc1ccc(C)c(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c1 nan
44607582 35026 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1436066 35026 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607582 35026 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1436066 35026 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
44607573 43832 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1514981 43832 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 10.1016/j.bmcl.2011.04.097
44607573 43832 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 nan
CHEMBL1514981 43832 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 nan
3609942 46604 1 None 4 4 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 415 2 0 5 4.6 COC(=O)C1CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
CHEMBL1540682 46604 1 None 4 4 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 415 2 0 5 4.6 COC(=O)C1CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
4879810 40662 8 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 2 1 5 1.5 O=C1CN(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c2ccccc2N1 nan
CHEMBL1486546 40662 8 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 2 1 5 1.5 O=C1CN(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c2ccccc2N1 nan
706322 22941 9 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
CHEMBL1331049 22941 9 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
54585466 62055 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 431 5 1 4 6.2 CC(=O)OCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779733 62055 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 431 5 1 4 6.2 CC(=O)OCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
53358423 62136 1 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 341 4 2 4 4.7 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(CO)cc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779919 62136 1 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 341 4 2 4 4.7 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(CO)cc2C)o1 10.1016/j.bmcl.2011.04.097
6552076 19515 1 None 9 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 487 4 0 7 4.5 COC(=O)C[C@]1(C(=O)OC)CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
CHEMBL1301125 19515 1 None 9 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 487 4 0 7 4.5 COC(=O)C[C@]1(C(=O)OC)CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
6217704 32352 3 None -7 6 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
CHEMBL1412583 32352 3 None -7 6 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
2035866 27549 10 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1370681 27549 10 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
54584548 62123 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 416 5 1 3 6.2 Cc1cc(CN(C)C)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779903 62123 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 416 5 1 3 6.2 Cc1cc(CN(C)C)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
9551645 36524 5 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1449794 36524 5 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
2418645 48424 7 None 2 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 380 4 0 5 1.9 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1558021 48424 7 None 2 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 380 4 0 5 1.9 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(Cc2ccccc2)CC1 nan
2219262 34408 11 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1429929 34408 11 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
3247230 49770 3 None 1 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
CHEMBL1569585 49770 3 None 1 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
6526694 27383 3 None 7 5 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
CHEMBL1369594 27383 3 None 7 5 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
2330223 45322 6 None 5 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
CHEMBL1529115 45322 6 None 5 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
1363299 32709 10 None 37 5 Human 7.4 pIC50 = 7.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
CHEMBL1415555 32709 10 None 37 5 Human 7.4 pIC50 = 7.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
2801235 35340 29 None 7 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
CHEMBL1439384 35340 29 None 7 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
779010 52303 13 None - 1 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 345 3 1 2 5.8 Cc1ccccc1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1592813 52303 13 None - 1 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 345 3 1 2 5.8 Cc1ccccc1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
460749 23331 9 None 1 6 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
CHEMBL1334062 23331 9 None 1 6 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
1472225 24525 10 None 2 7 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 24525 10 None 2 7 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
4469648 62121 2 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 4 1 2 6.4 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779901 62121 2 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 4 1 2 6.4 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607578 52053 0 None 45 2 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 7 1 4 5.5 CCOc1ccc(OC)cc1-c1ccc(C(=O)Nc2c(C)cccc2CC)o1 nan
CHEMBL1589684 52053 0 None 45 2 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 7 1 4 5.5 CCOc1ccc(OC)cc1-c1ccc(C(=O)Nc2c(C)cccc2CC)o1 nan
44607576 47829 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1550998 47829 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607576 47829 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1550998 47829 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
367432 26529 12 None 15 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
CHEMBL1362503 26529 12 None 15 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
3006170 59221 7 None 2 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 325 3 5 9 -1.7 NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12 nan
CHEMBL171699 59221 7 None 2 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 325 3 5 9 -1.7 NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12 nan
1479791 35260 22 None 3 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 4 1.4 CC(=O)Cn1ncc(Br)c(Br)c1=O nan
CHEMBL1438636 35260 22 None 3 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 4 1.4 CC(=O)Cn1ncc(Br)c(Br)c1=O nan
54587490 62125 0 None 54 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 419 6 2 4 5.5 Cc1cc(OCCO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779905 62125 0 None 54 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 419 6 2 4 5.5 Cc1cc(OCCO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
54580604 62130 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccsc2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779913 62130 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccsc2)o1 10.1016/j.bmcl.2011.04.097
2215161 40702 6 None 4 3 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
CHEMBL1486934 40702 6 None 4 3 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
238775 42546 2 None 2 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
CHEMBL1502358 42546 2 None 2 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
54580605 62135 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 2 4 4.9 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(O)cc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779918 62135 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 2 4 4.9 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(O)cc2C)o1 10.1016/j.bmcl.2011.04.097
3247230 49770 3 None 1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
CHEMBL1569585 49770 3 None 1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
701067 27579 11 None 20 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 5 4.2 O=S1(=O)C=C(Sc2nc3ccccc3s2)c2ccccc21 nan
CHEMBL1370884 27579 11 None 20 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 5 4.2 O=S1(=O)C=C(Sc2nc3ccccc3s2)c2ccccc21 nan
878124 25724 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1354080 25724 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 10.1016/j.bmcl.2011.04.097
878124 25724 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 nan
CHEMBL1354080 25724 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 nan
54585494 62128 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 365 5 0 4 4.9 COc1ccc(OC)c(-c2ccc(C(=O)N(C)c3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779910 62128 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 365 5 0 4 4.9 COc1ccc(OC)c(-c2ccc(C(=O)N(C)c3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
44607572 30377 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 365 6 1 4 5.1 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(OC)ccc2OC)o1 nan
CHEMBL1393906 30377 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 365 6 1 4 5.1 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(OC)ccc2OC)o1 nan
54585495 62132 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 331 3 1 3 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)s2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779915 62132 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 331 3 1 3 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)s2)o1 10.1016/j.bmcl.2011.04.097
54582605 62111 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 432 6 2 4 5.0 Cc1cc(OCC(N)=O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779891 62111 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 432 6 2 4 5.0 Cc1cc(OCC(N)=O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
3838273 46910 13 None 1 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
CHEMBL1543295 46910 13 None 1 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
1472218 27391 12 None -1 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
CHEMBL1369655 27391 12 None -1 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
1473969 35450 11 None 14 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 373 4 1 2 4.7 O=C(Nc1ccccc1Cl)/C(Cl)=C(\Cl)[S+]([O-])c1ccccc1 nan
CHEMBL1440300 35450 11 None 14 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 373 4 1 2 4.7 O=C(Nc1ccccc1Cl)/C(Cl)=C(\Cl)[S+]([O-])c1ccccc1 nan
82533 40788 63 None 2 5 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
CHEMBL1487635 40788 63 None 2 5 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
1475337 20516 11 None -1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
CHEMBL1309232 20516 11 None -1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
54585493 62120 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 2 3 5.3 Cc1cccc(CO)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779900 62120 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 2 3 5.3 Cc1cccc(CO)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
54582609 62127 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 291 3 1 2 4.8 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779907 62127 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 291 3 1 2 4.8 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2011.04.097
54582607 62115 0 None 48 5 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 3 2 3 5.8 Cc1cc(O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779895 62115 0 None 48 5 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 3 2 3 5.8 Cc1cc(O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
2142309 196972 13 None 3 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 346 3 1 5 2.7 Cc1oc2c(c1C(=O)NCc1cccnc1)C(=O)c1ccccc1C2=O nan
CHEMBL579318 196972 13 None 3 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 346 3 1 5 2.7 Cc1oc2c(c1C(=O)NCc1cccnc1)C(=O)c1ccccc1C2=O nan
54581610 62116 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779896 62116 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
53388307 64809 0 None 18 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 335 3 1 2 5.9 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)s2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824254 64809 0 None 18 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 335 3 1 2 5.9 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)s2)c1 10.1016/j.bmcl.2011.06.132
2082098 40508 8 None 1 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 304 3 1 4 3.4 Cc1ccc(S(=O)(=O)Nc2cccc3ncccc23)s1 nan
CHEMBL1485168 40508 8 None 1 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 304 3 1 4 3.4 Cc1ccc(S(=O)(=O)Nc2cccc3ncccc23)s1 nan
51057916 62113 2 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 3 1 2 6.4 Cc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779893 62113 2 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 3 1 2 6.4 Cc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
82533 40788 63 None 2 5 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
CHEMBL1487635 40788 63 None 2 5 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
56682427 64808 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 332 3 1 2 5.2 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)n2C)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824253 64808 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 332 3 1 2 5.2 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)n2C)c1 10.1016/j.bmcl.2011.06.132
54580603 62129 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779911 62129 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
54580603 62129 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1779911 62129 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
54580601 62118 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 367 3 1 2 5.8 O=C(Nc1c(F)cccc1F)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779898 62118 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 367 3 1 2 5.8 O=C(Nc1c(F)cccc1F)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
14286542 71861 4 None 4 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 401 2 3 4 2.9 CC1=CC2/C=C(\C)CCC(O)C(O)/C=C/C(=O)C23C(=O)NC(CC(C)C)C3C1C nan
CHEMBL1981103 71861 4 None 4 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 401 2 3 4 2.9 CC1=CC2/C=C(\C)CCC(O)C(O)/C=C/C(=O)C23C(=O)NC(CC(C)C)C3C1C nan
4019447 19319 7 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
CHEMBL1299526 19319 7 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
2017227 29382 8 None 10 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 360 3 0 3 4.9 CC(=O)n1cc(N(C(=O)CCl)c2ccc(Cl)cc2)c2ccccc21 nan
CHEMBL1385784 29382 8 None 10 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 360 3 0 3 4.9 CC(=O)n1cc(N(C(=O)CCl)c2ccc(Cl)cc2)c2ccccc21 nan
11957208 55892 2 None 5 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
CHEMBL1340713 55892 2 None 5 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
CHEMBL1626334 55892 2 None 5 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
2801236 79763 6 None 7 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
CHEMBL213580 79763 6 None 7 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
12005127 44538 3 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 6 0 4 4.6 COc1cc(/C=C(/C)[N+](=O)[O-])ccc1OCc1ccccc1Cl nan
CHEMBL1521989 44538 3 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 6 0 4 4.6 COc1cc(/C=C(/C)[N+](=O)[O-])ccc1OCc1ccccc1Cl nan
6526694 27383 3 None 7 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
CHEMBL1369594 27383 3 None 7 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
53388308 64814 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 329 3 1 1 5.8 Cc1ccc(C)c(-c2cccc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824259 64814 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 329 3 1 1 5.8 Cc1ccc(C)c(-c2cccc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
1218173 52509 8 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 319 2 0 5 2.9 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccccn1 nan
CHEMBL1595015 52509 8 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 319 2 0 5 2.9 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccccn1 nan
5759185 38426 3 None 4 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
CHEMBL1465592 38426 3 None 4 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
1336753 29935 14 None 7 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
CHEMBL1390139 29935 14 None 7 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
4492589 30677 7 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1397874 30677 7 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
4492589 30677 7 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.06.132
CHEMBL1397874 30677 7 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.06.132
11957215 55453 2 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
CHEMBL1503962 55453 2 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
CHEMBL1622468 55453 2 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
54582606 62114 0 None 35 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 1 3 6.1 COc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779894 62114 0 None 35 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 1 3 6.1 COc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
54586461 62112 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 3 0 2 6.5 Cc1cc(C)c(N(C)C(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779892 62112 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 3 0 2 6.5 Cc1cc(C)c(N(C)C(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
2328694 53431 2 None 8 5 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
CHEMBL1603615 53431 2 None 8 5 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
1472218 27391 12 None -1 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
CHEMBL1369655 27391 12 None -1 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
2219262 34408 11 None 4 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1429929 34408 11 None 4 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
706322 22941 9 None - 1 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
CHEMBL1331049 22941 9 None - 1 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
1475343 34682 13 None 2 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 430 7 1 6 3.3 COc1ccc(CS(=O)(=O)/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
CHEMBL1432251 34682 13 None 2 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 430 7 1 6 3.3 COc1ccc(CS(=O)(=O)/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
100520 32491 5 None 4 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
CHEMBL1413680 32491 5 None 4 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
367432 26529 12 None 15 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
CHEMBL1362503 26529 12 None 15 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
1474490 23442 14 None -3 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
CHEMBL1334984 23442 14 None -3 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
1474490 23442 14 None -3 3 Human 4.1 pIC50 = 4.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
CHEMBL1334984 23442 14 None -3 3 Human 4.1 pIC50 = 4.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
44607580 21316 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1316334 21316 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607580 21316 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1316334 21316 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
56679130 64813 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2oc(C(=O)Nc3c(C)cccc3C)cc2C)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824258 64813 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2oc(C(=O)Nc3c(C)cccc3C)cc2C)c1 10.1016/j.bmcl.2011.06.132
2295300 36173 10 None 3 5 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
CHEMBL1446971 36173 10 None 3 5 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
54583567 62133 0 None 28 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779916 62133 0 None 28 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
54584547 62117 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779897 62117 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
54580602 62122 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 430 5 2 3 5.8 CC(=O)NCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779902 62122 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 430 5 2 3 5.8 CC(=O)NCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
2215161 40702 6 None 4 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
CHEMBL1486934 40702 6 None 4 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
5286552 26448 9 None 3 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 251 6 0 5 1.9 CCOC(=O)COc1ccccc1/C=C\[N+](=O)[O-] nan
CHEMBL1361821 26448 9 None 3 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 251 6 0 5 1.9 CCOC(=O)COc1ccccc1/C=C\[N+](=O)[O-] nan
5516000 36724 8 None 1 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 512 7 1 5 5.8 O=C(NCc1cccnc1)/C(=C\c1ccc(-c2ccc(Cl)c(Cl)c2)o1)S(=O)(=O)c1ccccc1 nan
CHEMBL1451470 36724 8 None 1 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 512 7 1 5 5.8 O=C(NCc1cccnc1)/C(=C\c1ccc(-c2ccc(Cl)c(Cl)c2)o1)S(=O)(=O)c1ccccc1 nan
3270222 36602 6 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
CHEMBL1450393 36602 6 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
238775 42546 2 None 2 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
CHEMBL1502358 42546 2 None 2 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
3245258 34540 1 None 3 3 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 5 2.6 CS(=O)(=O)c1nc(-c2cccs2)cc(C(F)(F)F)n1 nan
CHEMBL1430895 34540 1 None 3 3 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 5 2.6 CS(=O)(=O)c1nc(-c2cccs2)cc(C(F)(F)F)n1 nan
49848557 1077 0 None -15848 5 Human 4.4 pEC50 < 4.4 Functional
In an aequorin calcium accumulation assay.In an aequorin calcium accumulation assay.
Guide to Pharmacology 461 7 1 8 4.0 OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C 26751273
9492 1077 0 None -15848 5 Human 4.4 pEC50 < 4.4 Functional
In an aequorin calcium accumulation assay.In an aequorin calcium accumulation assay.
Guide to Pharmacology 461 7 1 8 4.0 OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C 26751273
CHEMBL3769933 1077 0 None -15848 5 Human 4.4 pEC50 < 4.4 Functional
In an aequorin calcium accumulation assay.In an aequorin calcium accumulation assay.
Guide to Pharmacology 461 7 1 8 4.0 OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C 26751273
52938427 2924 47 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
5383 2924 47 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
8709 2924 47 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
CHEMBL3707247 2924 47 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
DB12612 2924 47 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
11363176 3088 42 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
5446 3088 42 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
9320 3088 42 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
CHEMBL1096146 3088 42 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
44599207 3539 40 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
5326 3539 40 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
9289 3539 40 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
CHEMBL2336071 3539 40 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
DB12371 3539 40 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
107970 1601 76 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
2407 1601 76 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
4167 1601 76 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
CHEMBL314854 1601 76 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
DB08868 1601 76 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
44623998 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
44623998 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
9331 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
9331 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
CHEMBL3358920 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
CHEMBL3358920 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
DB14766 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
DB14766 1560 33 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
44599207 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
5326 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
9289 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
CHEMBL2336071 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
DB12371 3539 40 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
16755143 499 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
9569 499 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
CHEMBL4297350 499 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
DB11819 499 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
124221654 1100 1 None 2 2 Human 6.7 pEC50 = 6.7 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
9495 1100 1 None 2 2 Human 6.7 pEC50 = 6.7 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
CHEMBL3884038 1100 1 None 2 2 Human 6.7 pEC50 = 6.7 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
124221654 1100 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
In a cAMP assay.In a cAMP assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
9495 1100 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
In a cAMP assay.In a cAMP assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
CHEMBL3884038 1100 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
In a cAMP assay.In a cAMP assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
10883396 3579 39 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
5283560 3579 39 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
911 3579 39 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
CHEMBL225155 3579 39 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
2924 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
2924 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
44398069 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
44398069 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
9908268 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
9908268 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
CHEMBL114606 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
CHEMBL114606 1602 37 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
10311 1262 34 None 37 2 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 21982495
49835928 1262 34 None 37 2 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 21982495
CHEMBL1910803 1262 34 None 37 2 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 21982495
10883396 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
10883396 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
10883396 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
5283560 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
5283560 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
5283560 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
911 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
911 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
911 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
CHEMBL225155 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
CHEMBL225155 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
CHEMBL225155 3579 39 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
6992 3934 0 None -7 2 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869
73755254 3934 0 None -7 2 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869
2924 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
2924 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
2924 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
2924 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
2924 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
44398069 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
44398069 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
44398069 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
44398069 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
44398069 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
9908268 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
9908268 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
9908268 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
9908268 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
9908268 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
CHEMBL114606 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
CHEMBL114606 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
CHEMBL114606 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
CHEMBL114606 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
CHEMBL114606 1602 37 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
10904818 300 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 11967257
10904818 300 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 14732717
2937 300 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 11967257
2937 300 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 14732717
CHEMBL382739 300 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 11967257
CHEMBL382739 300 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 14732717
52938427 2924 47 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
5383 2924 47 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
8709 2924 47 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
CHEMBL3707247 2924 47 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
DB12612 2924 47 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
11259583 520 12 None -3548 7 Mouse 5.5 pEC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 7 2 3 6.8 OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 17114004
2925 520 12 None -3548 7 Mouse 5.5 pEC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 7 2 3 6.8 OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 17114004
CHEMBL4579553 520 12 None -3548 7 Mouse 5.5 pEC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 7 2 3 6.8 OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 17114004
2923 2160 0 None -11 2 Mouse 8.0 pEC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 509 11 4 6 5.0 OCC(COP(=O)(O)O)(CCc1ccc(cc1Cl)Sc1cccc(c1)Oc1ccccc1)N 17898319
56947075 2160 0 None -11 2 Mouse 8.0 pEC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 509 11 4 6 5.0 OCC(COP(=O)(O)O)(CCc1ccc(cc1Cl)Sc1cccc(c1)Oc1ccccc1)N 17898319
67468687 2160 0 None -11 2 Mouse 8.0 pEC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 509 11 4 6 5.0 OCC(COP(=O)(O)O)(CCc1ccc(cc1Cl)Sc1cccc(c1)Oc1ccccc1)N 17898319
10312 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 21570287
10312 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 23913862
53358422 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 21570287
53358422 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 23913862
CHEMBL1779732 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 21570287
CHEMBL1779732 1263 16 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 23913862
10883396 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
10883396 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
5283560 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
5283560 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
911 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
911 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
CHEMBL225155 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
CHEMBL225155 3579 39 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
10430549 1029 33 None -114 4 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 16190743
2929 1029 33 None -114 4 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 16190743
CHEMBL194419 1029 33 None -114 4 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 16190743
2921 1389 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
44317142 1389 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
644260 1389 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
CHEMBL78494 1389 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
10883829 3057 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 397 18 5 5 3.2 CCCCCCCCCCCCCC[C@H]([C@H]([C@H](COP(=O)(O)O)N)O)O 12270137
2922 3057 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 397 18 5 5 3.2 CCCCCCCCCCCCCC[C@H]([C@H]([C@H](COP(=O)(O)O)N)O)O 12270137
46891723 3057 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 397 18 5 5 3.2 CCCCCCCCCCCCCC[C@H]([C@H]([C@H](COP(=O)(O)O)N)O)O 12270137


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
107970 1601 76 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
2407 1601 76 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
4167 1601 76 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
CHEMBL314854 1601 76 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
DB08868 1601 76 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
49868651 170572 0 None - 0 Human 9.3 pEC50 = 9.3 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 542 8 2 8 5.3 O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
CHEMBL4458575 170572 0 None - 0 Human 9.3 pEC50 = 9.3 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 542 8 2 8 5.3 O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
50925337 169874 6 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 528 7 2 8 4.9 O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
CHEMBL4448752 169874 6 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 528 7 2 8 4.9 O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
134131598 141726 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 373 4 1 3 5.2 O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 10.1016/j.bmcl.2016.11.050
CHEMBL3884966 141726 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 373 4 1 3 5.2 O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 10.1016/j.bmcl.2016.11.050
134130192 141660 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3884134 141660 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131497 141603 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 7 2 3 4.9 CCc1ccccc1-c1cccc2sc(CNCC(C)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883549 141603 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 7 2 3 4.9 CCc1ccccc1-c1cccc2sc(CNCC(C)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134130884 141606 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883572 141606 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
134130150 141595 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3883471 141595 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131253 141749 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 367 9 2 3 5.5 CCc1ccccc1-c1cccc2sc(CNCCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885187 141749 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 367 9 2 3 5.5 CCc1ccccc1-c1cccc2sc(CNCCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134130662 141730 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3884995 141730 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131209 141774 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885415 141774 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 10.1016/j.bmcl.2016.11.050
44394289 12288 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 3.7 CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1185803 12288 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 3.7 CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL433593 12288 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 3.7 CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
134131399 141771 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885401 141771 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 10.1016/j.bmcl.2016.11.050
44342331 11296 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 428 16 4 4 4.5 CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL116953 11296 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 428 16 4 4 4.5 CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1180214 11296 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 428 16 4 4 4.5 CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134131067 141641 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 10.1016/j.bmcl.2016.11.050
CHEMBL3883991 141641 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 10.1016/j.bmcl.2016.11.050
44623998 1560 33 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
9331 1560 33 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
CHEMBL3358920 1560 33 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
DB14766 1560 33 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
134130111 141759 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3885275 141759 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
11682677 11662 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181748 11662 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL190865 11662 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
44342339 11286 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL114031 11286 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1180115 11286 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
44398076 12776 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 13 5 5 3.2 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1188968 12776 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 13 5 5 3.2 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL537849 12776 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 13 5 5 3.2 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
44394521 11641 1 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1181640 11641 1 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL186815 11641 1 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
134131071 141577 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883377 141577 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
44398012 12143 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 12 4 4 4.4 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1184707 12143 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 12 4 4 4.4 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL364950 12143 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 12 4 4 4.4 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
134131075 141586 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 8 2 3 5.1 CCc1ccccc1-c1cccc2sc(CNCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883420 141586 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 8 2 3 5.1 CCc1ccccc1-c1cccc2sc(CNCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134131081 141594 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883456 141594 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
44398170 11652 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 411 12 4 4 4.2 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181688 11652 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 411 12 4 4 4.2 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL188826 11652 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 411 12 4 4 4.2 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
134131363 141706 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3ccc(C(F)(F)F)cc3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884795 141706 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3ccc(C(F)(F)F)cc3)c2s1 10.1016/j.bmcl.2016.11.050
134130292 141767 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 405 8 2 4 5.7 COc1ccc2cc(-c3cccc4cc(CNCCCC(=O)O)sc34)ccc2c1 10.1016/j.bmcl.2016.11.050
CHEMBL3885357 141767 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 405 8 2 4 5.7 COc1ccc2cc(-c3cccc4cc(CNCCCC(=O)O)sc34)ccc2c1 10.1016/j.bmcl.2016.11.050
134130114 141727 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cccc(-c3cccc4ccccc34)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884986 141727 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cccc(-c3cccc4ccccc34)c2s1 10.1016/j.bmcl.2016.11.050
134130375 141658 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
CHEMBL3884099 141658 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
124221654 1100 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
9495 1100 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
CHEMBL3884038 1100 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
134130947 141685 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3ccc(-c4ccccc4)cc3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884580 141685 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3ccc(-c4ccccc4)cc3)c2s1 10.1016/j.bmcl.2016.11.050
134131381 141765 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3885331 141765 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
59393720 2769 23 None - 1 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 464 7 3 3 6.3 OC(=O)[C@@H](NC(=O)c1c(C)cc(cc1C)c1cccc(c1)N[C@@H](c1ccc(c(c1)C)Cl)C)C 10.1016/j.bmcl.2013.09.058
6997 2769 23 None - 1 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 464 7 3 3 6.3 OC(=O)[C@@H](NC(=O)c1c(C)cc(cc1C)c1cccc(c1)N[C@@H](c1ccc(c(c1)C)Cl)C)C 10.1016/j.bmcl.2013.09.058
CHEMBL3086703 2769 23 None - 1 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 464 7 3 3 6.3 OC(=O)[C@@H](NC(=O)c1c(C)cc(cc1C)c1cccc(c1)N[C@@H](c1ccc(c(c1)C)Cl)C)C 10.1016/j.bmcl.2013.09.058
134131475 141643 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3ccc(CC(=O)O)cc3)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883998 141643 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3ccc(CC(=O)O)cc3)cc12 10.1016/j.bmcl.2016.11.050
49839234 117435 1 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 472 6 3 3 6.1 O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 10.1016/j.bmcl.2014.11.089
CHEMBL3403619 117435 1 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 472 6 3 3 6.1 O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 10.1016/j.bmcl.2014.11.089
10883396 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
5283560 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
911 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
CHEMBL225155 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
10883396 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
5283560 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
911 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
CHEMBL225155 3579 39 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
134131188 141754 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885229 141754 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 10.1016/j.bmcl.2016.11.050
44394539 11631 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 303 9 3 3 3.8 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1181600 11631 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 303 9 3 3 3.8 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL183888 11631 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 303 9 3 3 3.8 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)O)nc2c1 10.1016/j.bmcl.2004.07.030
134130066 141709 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3cccc(-c4ccccc4)c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884809 141709 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3cccc(-c4ccccc4)c3)c2s1 10.1016/j.bmcl.2016.11.050
134131470 141751 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3ccc(CC(=O)O)cc3)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885195 141751 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3ccc(CC(=O)O)cc3)sc12 10.1016/j.bmcl.2016.11.050
134130316 141778 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3885468 141778 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
44394459 123107 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
CHEMBL361915 123107 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
10883396 3579 39 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
5283560 3579 39 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
911 3579 39 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
CHEMBL225155 3579 39 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
134130519 141637 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883972 141637 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
134131256 141633 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 369 7 2 5 4.3 O=C(O)CCCNCc1cc2cccc(-c3ccc4c(c3)OCO4)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883947 141633 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 369 7 2 5 4.3 O=C(O)CCCNCc1cc2cccc(-c3ccc4c(c3)OCO4)c2s1 10.1016/j.bmcl.2016.11.050
44398058 11646 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181660 11646 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL187712 11646 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
2924 1602 37 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
44398069 1602 37 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
9908268 1602 37 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
CHEMBL114606 1602 37 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
134129983 141604 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883555 141604 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
46174905 115775 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
CHEMBL3358955 115775 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
44394564 12137 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1184660 12137 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL363076 12137 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
134130546 141625 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883812 141625 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
10023913 12012 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 400 14 4 4 3.7 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1184130 12012 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 400 14 4 4 3.7 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL334038 12012 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 400 14 4 4 3.7 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134130145 141580 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3cccc(CC(=O)O)c3)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883399 141580 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3cccc(CC(=O)O)c3)cc12 10.1016/j.bmcl.2016.11.050
44394497 66346 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
CHEMBL185491 66346 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
44342175 85081 0 None - 2 Human 6.3 pEC50 = 6.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL227371 85081 0 None - 2 Human 6.3 pEC50 = 6.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL422074 85081 0 None - 2 Human 6.3 pEC50 = 6.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134131169 141719 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 381 7 2 3 5.8 CC(C)(C)c1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
CHEMBL3884888 141719 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 381 7 2 3 5.8 CC(C)(C)c1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
134130023 141667 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3884173 141667 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
46174905 115775 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
CHEMBL3358955 115775 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
134130071 141714 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2sc(CNCC(N)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3884862 141714 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2sc(CNCC(N)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134130695 141592 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883447 141592 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
44398074 12762 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 345 11 4 4 3.1 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1188885 12762 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 345 11 4 4 3.1 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL537632 12762 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 345 11 4 4 3.1 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
134130732 141650 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3cccc(C(F)(F)F)c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884056 141650 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3cccc(C(F)(F)F)c3)c2s1 10.1016/j.bmcl.2016.11.050
134129958 141736 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3885074 141736 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131297 141613 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883621 141613 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
44398172 11659 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 315 10 3 3 4.0 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181739 11659 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 315 10 3 3 4.0 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL190529 11659 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 315 10 3 3 4.0 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
134130571 141673 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 10.1016/j.bmcl.2016.11.050
CHEMBL3884292 141673 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 10.1016/j.bmcl.2016.11.050
53362086 115842 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 481 7 1 4 6.6 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F 10.1021/ml500422m
CHEMBL3359523 115842 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 481 7 1 4 6.6 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F 10.1021/ml500422m
67250226 115841 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 438 7 1 5 5.5 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C#N 10.1021/ml500422m
CHEMBL3359522 115841 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 438 7 1 5 5.5 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C#N 10.1021/ml500422m
44342219 11291 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL115344 11291 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1180152 11291 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
44398049 13052 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 441 13 5 5 3.4 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1190950 13052 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 441 13 5 5 3.4 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL541890 13052 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 441 13 5 5 3.4 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
11675907 11656 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 409 12 4 4 4.3 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181694 11656 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 409 12 4 4 4.3 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL188881 11656 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 409 12 4 4 4.3 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
44342468 11997 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1184089 11997 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL332050 11997 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134130131 141743 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 10.1016/j.bmcl.2016.11.050
CHEMBL3885151 141743 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 10.1016/j.bmcl.2016.11.050
44394327 11632 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 4.0 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1181601 11632 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 4.0 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL183894 11632 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 4.0 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
10883396 3579 39 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
5283560 3579 39 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
911 3579 39 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
CHEMBL225155 3579 39 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
44591265 179391 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 425 13 4 5 4.1 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2008.11.072
CHEMBL474689 179391 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 425 13 4 5 4.1 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2008.11.072
44565739 178372 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 459 12 4 5 4.2 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL470511 178372 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 459 12 4 5 4.2 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
10150171 167435 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 357 13 3 3 4.0 CCCCCCCCc1ccc(CCC(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL432067 167435 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 357 13 3 3 4.0 CCCCCCCCc1ccc(CCC(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44591264 179389 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)c(F)c1 10.1016/j.bmcl.2008.11.072
CHEMBL474688 179389 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)c(F)c1 10.1016/j.bmcl.2008.11.072
44591266 178710 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 443 13 4 5 4.2 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F 10.1016/j.bmcl.2008.11.072
CHEMBL473269 178710 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 443 13 4 5 4.2 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F 10.1016/j.bmcl.2008.11.072
44565596 188945 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 422 11 4 5 2.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL514302 188945 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 422 11 4 5 2.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
11540052 179975 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
CHEMBL475405 179975 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
44412221 76742 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL207580 76742 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44412233 77768 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL210352 77768 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
10174255 84779 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 485 6 1 6 5.7 O=C(O)C1CN(Cc2ccc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)cc2)C1 10.1021/jm0492507
CHEMBL225575 84779 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 485 6 1 6 5.7 O=C(O)C1CN(Cc2ccc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)cc2)C1 10.1021/jm0492507
44565738 189151 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 445 11 4 5 3.8 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL515917 189151 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 445 11 4 5 3.8 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
44413365 77014 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 467 6 2 5 5.8 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCC(F)(F)CC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL208648 77014 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 467 6 2 5 5.8 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCC(F)(F)CC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44413447 138141 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 431 6 2 5 5.6 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL377828 138141 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 431 6 2 5 5.6 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44413446 77932 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 417 6 2 5 5.2 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL211006 77932 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 417 6 2 5 5.2 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
11408903 84688 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 475 7 1 4 6.1 Cc1cc(CN2CC(C(=O)O)C2)cc(C)c1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
CHEMBL224853 84688 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 475 7 1 4 6.1 Cc1cc(CN2CC(C(=O)O)C2)cc(C)c1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
44394279 66799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 3 2 5.8 CCCCCCCCCCCCCC[C@H]1CC[C@H](CCP(=O)(O)O)N1 10.1016/j.bmcl.2004.07.049
CHEMBL187588 66799 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 3 2 5.8 CCCCCCCCCCCCCC[C@H]1CC[C@H](CCP(=O)(O)O)N1 10.1016/j.bmcl.2004.07.049
10125862 11505 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCCC(O)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL118068 11505 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCCC(O)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
11690779 189113 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 442 8 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(Oc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL515603 189113 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 442 8 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(Oc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
11503967 7924 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 482 10 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
CHEMBL1090796 7924 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 482 10 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
10217498 84648 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 481 7 1 4 6.2 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
CHEMBL224571 84648 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 481 7 1 4 6.2 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
44344390 13371 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 15 3 2 4.5 O=P(O)(O)CCCNCCCCCCCCCCc1ccccc1 10.1016/j.bmcl.2004.04.069
CHEMBL119349 13371 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 15 3 2 4.5 O=P(O)(O)CCCNCCCCCCCCCCc1ccccc1 10.1016/j.bmcl.2004.04.069
10215138 13952 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 15 3 2 4.6 CCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL119760 13952 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 15 3 2 4.6 CCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44344193 114401 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL334213 114401 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44344193 114401 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1021/jm0492507
CHEMBL334213 114401 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1021/jm0492507
10172545 9519 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.4 CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL112655 9519 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.4 CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44344193 114401 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
CHEMBL334213 114401 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
44341399 205229 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 724 25 7 5 7.9 CCCCCCCCc1ccc(CCC(N)/C=C/P(=O)(O)O)cc1.CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL91283 205229 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 724 25 7 5 7.9 CCCCCCCCc1ccc(CCC(N)/C=C/P(=O)(O)O)cc1.CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
10308738 10159 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCC(O)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL116140 10159 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCC(O)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
44344446 114310 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 17 3 2 5.4 CCCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL334144 114310 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 17 3 2 5.4 CCCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44412428 77877 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4F)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL210782 77877 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4F)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
24812110 10635 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 373 13 4 4 3.3 CCCCCCCCc1ccc(CCC(N)(CO)OP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL117130 10635 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 373 13 4 4 3.3 CCCCCCCCc1ccc(CCC(N)(CO)OP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
2924 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
44398069 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
9908268 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
CHEMBL114606 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
2924 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
44398069 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
9908268 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
CHEMBL114606 1602 37 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
46905530 10180 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 389 14 5 6 2.6 CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL1161691 10180 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 389 14 5 6 2.6 CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
10317453 70060 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 377 7 1 5 3.9 CCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL194578 70060 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 377 7 1 5 3.9 CCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
11495139 138362 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
CHEMBL378300 138362 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
44394149 123496 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 377 15 3 3 4.5 CCCCCCCCCCCCCCN1CCC(C(O)P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL363008 123496 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 377 15 3 3 4.5 CCCCCCCCCCCCCCN1CCC(C(O)P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
44412165 77393 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL209076 77393 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10288527 84591 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.8 Cc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
CHEMBL224005 84591 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.8 Cc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
10883396 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
5283560 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
911 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
CHEMBL225155 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
10883396 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
5283560 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
911 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
CHEMBL225155 3579 39 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
10384596 10026 2 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL115713 10026 2 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
44341276 9996 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL115554 9996 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44413430 138227 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
CHEMBL378061 138227 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
10127475 165465 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL425563 165465 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
10127475 165465 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
CHEMBL425563 165465 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
44394212 66819 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
CHEMBL187692 66819 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
11224984 8614 18 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
CHEMBL1095833 8614 18 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
10883396 3579 39 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
5283560 3579 39 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
911 3579 39 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
CHEMBL225155 3579 39 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
10883396 3579 39 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
5283560 3579 39 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
911 3579 39 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
CHEMBL225155 3579 39 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
44344194 11796 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 16 3 2 4.5 CCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL118265 11796 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 16 3 2 4.5 CCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44394220 66653 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL186921 66653 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
10271422 9829 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 385 14 4 3 3.8 CCCCCCCCc1ccc(CCC(N)(CO)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL114584 9829 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 385 14 4 3 3.8 CCCCCCCCc1ccc(CCC(N)(CO)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44412353 165664 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)c(F)c4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL426688 165664 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)c(F)c4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10883396 3579 39 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
5283560 3579 39 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
911 3579 39 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
CHEMBL225155 3579 39 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
9885762 9627 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CCC(N)CC(O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL113344 9627 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CCC(N)CC(O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44344404 11241 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 18 3 2 5.2 CCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL117973 11241 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 18 3 2 5.2 CCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44413482 165474 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 445 7 2 5 5.0 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL425602 165474 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 445 7 2 5 5.0 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44344413 110043 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCCc1ccc(CCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL325193 110043 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCCc1ccc(CCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
44565715 179851 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 498 12 4 5 4.5 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL475253 179851 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 498 12 4 5 4.5 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
10172338 110045 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL325198 110045 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
10251062 70278 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 411 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(-c5ccccc5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL195025 70278 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 411 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(-c5ccccc5)cc4)n3)cc2)C1 10.1021/jm0503244
10172338 110045 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL325198 110045 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
11466640 84652 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 525 7 1 4 6.3 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Br)c2)C1 10.1021/jm0492507
CHEMBL224599 84652 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 525 7 1 4 6.3 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Br)c2)C1 10.1021/jm0492507
9796603 163758 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 14 3 2 4.2 CCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL421234 163758 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 14 3 2 4.2 CCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
10215259 84669 5 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 331 11 1 2 4.9 CCCCCCCCCc1ccc(CN2CCC(C(=O)O)C2)cc1 10.1021/jm0492507
CHEMBL224703 84669 5 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 331 11 1 2 4.9 CCCCCCCCCc1ccc(CN2CCC(C(=O)O)C2)cc1 10.1021/jm0492507
11725751 12723 5 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL118860 12723 5 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
44565716 179153 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 493 10 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL474418 179153 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 493 10 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
11725751 12723 5 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL118860 12723 5 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
44413274 138169 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 6 2 4 5.7 O=C(O)C1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL377968 138169 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 6 2 4 5.7 O=C(O)C1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
11248292 142962 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 7 1 4 5.7 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(F)c2)C1 10.1021/jm0492507
CHEMBL389880 142962 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 7 1 4 5.7 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(F)c2)C1 10.1021/jm0492507
10384596 10026 2 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL115713 10026 2 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
10310952 84683 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 477 8 1 5 5.5 COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
CHEMBL224800 84683 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 477 8 1 5 5.5 COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
46885796 8311 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 538 10 4 5 4.8 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1 10.1016/j.bmcl.2010.02.098
CHEMBL1093429 8311 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 538 10 4 5 4.8 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1 10.1016/j.bmcl.2010.02.098
44591250 189152 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F 10.1016/j.bmcl.2008.11.072
CHEMBL515921 189152 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F 10.1016/j.bmcl.2008.11.072
44565597 178697 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 436 12 4 5 3.2 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473156 178697 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 436 12 4 5 3.2 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
44412232 165756 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL427221 165756 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44394191 65962 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL184879 65962 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
44394212 66819 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
CHEMBL187692 66819 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
44413349 77271 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL208838 77271 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44394273 64232 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 395 12 3 2 5.6 CCCCCCCCCc1ccc(CN[C@H]2CCC[C@H](P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL181597 64232 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 395 12 3 2 5.6 CCCCCCCCCc1ccc(CN[C@H]2CCC[C@H](P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
10174181 11149 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 479 16 3 4 5.2 CCCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1016/j.bmcl.2004.04.070
CHEMBL117910 11149 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 479 16 3 4 5.2 CCCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1016/j.bmcl.2004.04.070
10883396 3579 39 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
5283560 3579 39 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
911 3579 39 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
CHEMBL225155 3579 39 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
11168252 84646 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(C(F)(F)F)c2)C1 10.1021/jm0492507
CHEMBL224549 84646 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(C(F)(F)F)c2)C1 10.1021/jm0492507
44412416 77812 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 431 6 2 5 5.7 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL210520 77812 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 431 6 2 5 5.7 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10249887 70569 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL195141 70569 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
10249979 71287 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 393 7 1 6 3.7 CC(C)Oc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL196357 71287 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 393 7 1 6 3.7 CC(C)Oc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
44413415 138148 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 2 4 6.1 O=C(O)CC1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL377855 138148 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 2 4 6.1 O=C(O)CC1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
44591249 180044 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 402 13 4 5 3.2 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2008.11.072
CHEMBL475495 180044 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 402 13 4 5 3.2 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2008.11.072
11540052 179975 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL475405 179975 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
25008420 8364 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 547 9 4 5 5.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
CHEMBL1093823 8364 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 547 9 4 5 5.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
44565717 188929 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2010.02.098
CHEMBL514170 188929 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2010.02.098
44565717 188929 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL514170 188929 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
11725751 12723 5 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL118860 12723 5 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
9979368 71347 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 417 6 1 5 5.0 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL196534 71347 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 417 6 1 5 5.0 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
10193676 13612 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 2 2 5.2 CCCCCCCCCc1ccc(CNCCC(F)(F)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL119516 13612 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 2 2 5.2 CCCCCCCCCc1ccc(CNCCC(F)(F)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
11743459 140247 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 431 7 1 5 4.4 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL381872 140247 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 431 7 1 5 4.4 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1021/jm0503244
11502026 71095 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nnc(-c3ccc(CN4CC(C(=O)O)C4)cc3)o2)cc1 10.1021/jm0503244
CHEMBL196149 71095 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nnc(-c3ccc(CN4CC(C(=O)O)C4)cc3)o2)cc1 10.1021/jm0503244
10287034 65837 3 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1021/jm0492507
CHEMBL184349 65837 3 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1021/jm0492507
10408874 72130 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 403 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL198976 72130 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 403 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
44565714 178707 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 484 11 4 5 4.1 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473238 178707 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 484 11 4 5 4.1 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
44341466 9904 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL114976 9904 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
11653967 70215 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 389 6 1 5 4.2 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCC5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL194898 70215 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 389 6 1 5 4.2 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCC5)cc4)n3)cc2)C1 10.1021/jm0503244
44412294 138107 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL377637 138107 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
10149721 84659 4 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 317 11 1 2 4.5 CCCCCCCCCc1ccc(CN2CC(C(=O)O)C2)cc1 10.1021/jm0492507
CHEMBL224623 84659 4 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 317 11 1 2 4.5 CCCCCCCCCc1ccc(CN2CC(C(=O)O)C2)cc1 10.1021/jm0492507
44412165 77393 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL209076 77393 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10286857 167530 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 353 14 2 2 5.4 CCCCCCCCCc1ccc(CNCCCP(C)(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL432809 167530 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 353 14 2 2 5.4 CCCCCCCCCc1ccc(CNCCCP(C)(=O)O)cc1 10.1016/j.bmcl.2004.04.069
11683935 178751 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 456 9 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473563 178751 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 456 9 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
46885798 7934 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 561 10 4 5 5.7 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
CHEMBL1090829 7934 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 561 10 4 5 5.7 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
10125882 165021 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 337 14 2 2 4.9 CCCCCCCCCc1ccc(CNCC(F)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL424254 165021 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 337 14 2 2 4.9 CCCCCCCCCc1ccc(CNCC(F)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
44412415 77798 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL210468 77798 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44394248 65902 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 361 15 3 2 5.4 CCCCCCCCCCCCCCNC1CCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL184591 65902 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 361 15 3 2 5.4 CCCCCCCCCCCCCCNC1CCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
11696807 125423 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2noc(-c3ccc(CN4CC(C(=O)O)C4)cc3)n2)cc1 10.1021/jm0503244
CHEMBL364899 125423 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2noc(-c3ccc(CN4CC(C(=O)O)C4)cc3)n2)cc1 10.1021/jm0503244
11752659 165580 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.8 O=C(O)C1CN(Cc2cc(Cl)c(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
CHEMBL426191 165580 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.8 O=C(O)C1CN(Cc2cc(Cl)c(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
44344210 13680 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 15 3 2 4.1 CCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL119562 13680 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 15 3 2 4.1 CCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
11604577 71966 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL198415 71966 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
10430549 1029 33 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1021/jm0503244
2929 1029 33 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1021/jm0503244
CHEMBL194419 1029 33 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1021/jm0503244
10045980 69482 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 8 1 5 4.3 CCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL193789 69482 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 8 1 5 4.3 CCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
10430549 1029 33 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1016/j.bmcl.2006.03.090
2929 1029 33 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1016/j.bmcl.2006.03.090
CHEMBL194419 1029 33 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1016/j.bmcl.2006.03.090
44412282 77878 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL210785 77878 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44412165 77393 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL209076 77393 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
44412364 77734 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL210257 77734 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10363915 134657 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 7 1 5 4.6 CCC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL372066 134657 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 7 1 5 4.6 CCC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
10125861 13074 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 16 3 2 5.0 CCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL119110 13074 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 16 3 2 5.0 CCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44394220 66653 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL186921 66653 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
10195325 84682 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.9 O=C(O)C1CCN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
CHEMBL224799 84682 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.9 O=C(O)C1CCN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
44565622 178750 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 428 11 4 5 3.6 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCC2CCCCC2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473562 178750 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 428 11 4 5 3.6 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCC2CCCCC2)cc1 10.1016/j.bmcl.2009.02.073
44394191 65962 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL184879 65962 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
10127776 10935 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 15 3 4 4.9 CCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1021/jm0492507
CHEMBL117723 10935 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 15 3 4 4.9 CCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1021/jm0492507
21455530 10032 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 363 19 3 2 5.6 CCCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL115738 10032 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 363 19 3 2 5.6 CCCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44413349 77271 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL208838 77271 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44344412 13228 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCc1ccc(CCCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL119233 13228 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCc1ccc(CCCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
10287034 65837 3 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL184349 65837 3 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
44394169 66335 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 2 2 5.7 CCCCCCCCCCCCCCN1CCCC1CCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
CHEMBL185447 66335 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 2 2 5.7 CCCCCCCCCCCCCCN1CCCC1CCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
44341291 10027 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL115714 10027 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
11575787 70273 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL195014 70273 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
10476387 126980 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 6 1 5 4.5 CC(C)(C)Cc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL366181 126980 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 6 1 5 4.5 CC(C)(C)Cc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
44344360 10135 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 339 14 3 3 4.8 CCCCCCCCCc1ccc(CNCCCP(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL1160958 10135 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 339 14 3 3 4.8 CCCCCCCCCc1ccc(CNCCCP(O)O)cc1 10.1016/j.bmcl.2004.04.069
44394153 65810 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 363 14 3 3 4.3 CCCCCCCCCCCCCCN1CCC(O)(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL184237 65810 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 363 14 3 3 4.3 CCCCCCCCCCCCCCN1CCC(O)(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
44344456 10528 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 NC(CCCCCCCCCCc1ccccc1)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL117031 10528 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 NC(CCCCCCCCCCc1ccccc1)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
11502996 158169 36 None -50 4 Human 7.5 pKi = 7.5 Binding
Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodDisplacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting method
ChEMBL 435 9 1 4 5.0 CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 10.1021/acs.jmedchem.7b00785
CHEMBL4093489 158169 36 None -50 4 Human 7.5 pKi = 7.5 Binding
Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodDisplacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting method
ChEMBL 435 9 1 4 5.0 CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 10.1021/acs.jmedchem.7b00785
11363176 3088 42 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
5446 3088 42 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
9320 3088 42 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
CHEMBL1096146 3088 42 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
6992 3934 0 None -7 5 Human 7.8 pKd = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869
73755254 3934 0 None -7 5 Human 7.8 pKd = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869