GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	145971909	164137	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4217198	164137	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	66978356	163145	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4204996	163145	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127027876	138933	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3794302	138933	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	145978309	163189	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	CHEMBL4205480	163189	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	127029692	138861	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793515	138861	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11855868	152000	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152000	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	152731	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152731	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127026955	138907	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794016	138907	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	1883	3021	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1916	3021	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	5280360	3021	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	913	3021	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	CHEMBL548	3021	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	DB00917	3021	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	18376258	194218	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559065	194218	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	127026956	138883	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793862	138883	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	126495400	138778	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3792632	138778	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	1929	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	9890801	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	CHEMBL563646	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	DB12022	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	67082748	163800	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	CHEMBL4212770	163800	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	15979081	163277	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4206444	163277	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127051063	139779	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806284	139779	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	127027877	138876	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793802	138876	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	16725337	149057	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149057	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11294085	136715	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	CHEMBL3751951	136715	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	127028169	138947	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794466	138947	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	118352160	138886	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793892	138886	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	127027874	138820	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793045	138820	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	127027874	138820	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793045	138820	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	127051656	139751	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805981	139751	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443871	150901	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	CHEMBL3961932	150901	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	89443827	143569	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3903635	143569	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	18376082	193244	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541517	193244	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	145977227	163444	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4208379	163444	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	10315	2870	20	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	44230575	2870	20	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	CHEMBL3707245	2870	20	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	126495463	139764	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806130	139764	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11502897	142249	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142249	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145735	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145735	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855868	152000	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152000	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	152731	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152731	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44230722	171153	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4467099	171153	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855868	152000	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152000	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	127026953	138956	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794585	138956	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	1883	3021	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	1916	3021	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	5280360	3021	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	913	3021	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	CHEMBL548	3021	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	DB00917	3021	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	126495398	139668	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805044	139668	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443586	145140	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3916133	145140	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517489	143147	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143147	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	92135977	152351	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152351	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	8541	2888	1	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	2888	1	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	2888	1	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	59465571	145740	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920796	145740	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	118517361	152824	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152824	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	11955384	146993	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3930718	146993	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	45268715	194292	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559760	194292	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	16750455	150728	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3960352	150728	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53259980	175785	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4566584	175785	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595789	175785	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	126495507	138836	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793167	138836	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515776	153810	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3986985	153810	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	44304164	201534	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64483	201534	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118517485	142206	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	142206	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	71515515	150460	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	CHEMBL3958411	150460	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	126495427	138923	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794185	138923	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11955193	143040	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3899346	143040	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	155550016	176098	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4539881	176098	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598324	176098	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	53260150	175948	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451786	175948	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597091	175948	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855590	143829	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143829	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855591	143891	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143891	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	11855591	143891	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143891	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	118517360	143431	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	CHEMBL3902700	143431	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	118517489	143147	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143147	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	11955257	153340	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3983069	153340	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	118352211	138842	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793209	138842	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	118352211	138842	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793209	138842	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	126495491	139682	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805169	139682	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127050452	139701	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805408	139701	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	53260293	175629	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594090	175629	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	89443700	152042	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	CHEMBL3971868	152042	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	89444072	148400	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3941975	148400	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	44303952	100406	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293697	100406	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10270893	93780	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249954	93780	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	9885481	193703	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL551951	193703	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	11855325	144146	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	144146	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127050451	139678	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805122	139678	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443781	148734	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	CHEMBL3944601	148734	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	10481859	74802	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	CHEMBL2036321	74802	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	44303627	201506	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64358	201506	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	134146425	148659	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3943966	148659	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855591	143891	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143891	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	10291963	84270	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL222715	84270	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	127029402	138815	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793009	138815	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	24760052	150641	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	150641	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	17751059	147724	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	147724	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89444124	142887	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3898152	142887	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	156014791	177000	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4640635	177000	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	57464006	74803	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036322	74803	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	10269242	155023	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404413	155023	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465577	142645	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896183	142645	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	59465570	142715	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896693	142715	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	134143292	144683	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3912658	144683	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465574	145400	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	CHEMBL3918084	145400	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	59465601	149350	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3949271	149350	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	58681356	149826	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3953307	149826	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442327	94010	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251294	94010	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11855870	145735	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145735	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145735	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145735	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	71515516	147762	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3936868	147762	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	71516448	152016	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3971730	152016	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	57893848	74804	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036323	74804	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	118517488	153165	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153165	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	58708286	153798	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	CHEMBL3986874	153798	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	1929	1569	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	9890801	1569	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	CHEMBL563646	1569	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	DB12022	1569	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	89444254	142236	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3892751	142236	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	89443784	142362	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3893770	142362	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89444126	146843	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3929662	146843	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	11955383	141989	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3890808	141989	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53260155	170828	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4462507	170828	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	117703250	143095	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3899837	143095	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	89444132	143322	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3901709	143322	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443635	151360	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3965998	151360	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	57394893	70947	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957435	70947	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	10291963	84270	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	CHEMBL222715	84270	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	57394893	70947	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957435	70947	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	11855867	145438	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145438	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855867	145438	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145438	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44455115	95105	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257658	95105	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	1883	3021	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	1916	3021	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	5280360	3021	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	913	3021	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	CHEMBL548	3021	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	DB00917	3021	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	53259985	175893	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4548451	175893	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596602	175893	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	44442332	94078	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251709	94078	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	127026952	138818	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793020	138818	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	59465581	143568	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	143568	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	145966519	163836	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4213312	163836	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	44230429	175744	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4471378	175744	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595426	175744	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443841	145350	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3917749	145350	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	89444231	145568	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3919482	145568	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443843	148253	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3940781	148253	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443583	149933	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	CHEMBL3954347	149933	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	66857988	163559	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4209929	163559	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	5283086	201610	19	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL64804	201610	19	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	118352285	138926	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794226	138926	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	18376196	193243	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541516	193243	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	70815687	175962	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4515583	175962	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597208	175962	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	138	3020	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	1882	3020	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	5280723	3020	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL495	3020	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	DB00770	3020	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	53260134	175678	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466224	175678	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594970	175678	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53259986	175936	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4442505	175936	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596979	175936	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	53259987	175914	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4591201	175914	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596748	175914	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	9807448	201473	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	201473	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118352215	138874	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	CHEMBL3793797	138874	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	11855865	152731	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152731	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	10126807	193418	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549869	193418	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11955273	152243	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3973644	152243	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	138107701	186871	39	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	5311181	186871	39	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	CHEMBL494	186871	39	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	59465583	142730	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3896863	142730	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	11855594	152435	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152435	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152435	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152435	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	145863	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145863	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	145863	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145863	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	54013831	145915	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3922151	145915	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	10363130	100553	0	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL294585	100553	0	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9975502	94040	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251504	94040	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	24760052	150641	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	150641	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	70667255	150930	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	150930	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	72950089	150046	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL3955128	150046	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	11955180	151116	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	CHEMBL3963968	151116	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	10089562	153876	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398948	153876	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	118352177	138869	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793724	138869	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	127051064	139756	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806060	139756	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	89443417	151048	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	CHEMBL3963438	151048	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	44455046	95270	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL258332	95270	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	56839536	142625	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	CHEMBL3896035	142625	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	57529188	146650	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146650	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	89443813	151194	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3964577	151194	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517359	143851	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143851	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	57384034	70948	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957436	70948	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	57384034	70948	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957436	70948	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	11955194	150459	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3958410	150459	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58708282	152578	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3976452	152578	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	58681352	153793	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	CHEMBL3986829	153793	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	126495360	139691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805316	139691	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	11855866	144057	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144057	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443595	144416	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3910551	144416	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	57894053	74805	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036324	74805	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	118517359	143851	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143851	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	126495420	139706	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805455	139706	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11855324	142061	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	71515514	147081	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3931335	147081	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	11955198	146698	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3928466	146698	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	155541719	175798	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4519118	175798	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595870	175798	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	132836	59368	20	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL1722929	59368	20	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	155532079	171113	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466523	171113	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44455084	97405	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL272277	97405	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	59465581	143568	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	143568	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443767	145167	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3916293	145167	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443716	146481	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3926711	146481	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443671	147293	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3932999	147293	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89445501	151732	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	CHEMBL3969269	151732	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	89443873	153394	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3983500	153394	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	127051062	139731	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805767	139731	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	46931421	175679	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4476670	175679	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594971	175679	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	126495424	139712	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805554	139712	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	127052615	139727	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805693	139727	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127027875	138873	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793786	138873	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	127026954	138877	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	CHEMBL3793809	138877	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	127027875	138873	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793786	138873	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127052614	139683	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805176	139683	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	118517490	152609	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	152609	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	44230723	175921	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4473407	175921	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596867	175921	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	134155748	150625	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	150625	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	145965248	163667	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4211120	163667	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	11855867	145438	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145438	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	58681361	144136	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3908432	144136	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44304181	201573	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64663	201573	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	58932683	74922	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037289	74922	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	11955178	153241	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3982222	153241	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	44303980	167500	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL432522	167500	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	1883	3021	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3021	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3021	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3021	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3021	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3021	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	17757350	152210	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152210	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444121	146887	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3929987	146887	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	45271237	193419	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549870	193419	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	66858036	163328	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4207054	163328	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	59465599	146016	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922856	146016	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	59465600	151154	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3964261	151154	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58681358	150114	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3955642	150114	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442331	94041	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251505	94041	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44230430	175786	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449902	175786	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595790	175786	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	71515518	142262	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3892911	142262	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443584	144632	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3912323	144632	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	118517361	152824	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152824	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	155542681	176016	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4521659	176016	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597685	176016	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	11955156	147910	0	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3937945	147910	0	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	118689427	151308	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	CHEMBL3965497	151308	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	57893982	74799	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036318	74799	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	11955259	146214	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3924405	146214	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	57529188	146650	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146650	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57529188	146650	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146650	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44303626	167608	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL433249	167608	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	56839344	151507	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3967284	151507	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	11955196	143877	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3906280	143877	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44444722	93808	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL250153	93808	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	17751059	147724	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	147724	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	17757350	152210	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152210	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444221	143736	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3904996	143736	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	53259981	175766	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4456588	175766	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595646	175766	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	53259984	175951	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4447271	175951	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597100	175951	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53260154	170555	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4458330	170555	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	11955276	150206	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	CHEMBL3956391	150206	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	22246893	194268	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559561	194268	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855588	146812	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146812	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855588	146812	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146812	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	22246765	193518	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL550619	193518	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	22246895	193881	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL554823	193881	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855866	144057	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144057	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	144057	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144057	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57564500	150666	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	150666	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44230997	169959	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449855	169959	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44304199	100337	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293242	100337	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9821171	97404	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL272276	97404	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	10223499	194657	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562411	194657	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855324	142061	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855324	142061	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	53259982	175851	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4561017	175851	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596258	175851	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	89443872	145296	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3917219	145296	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	44304124	102137	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL304225	102137	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	11955297	149343	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3949225	149343	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	22246983	194179	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL558671	194179	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	23729077	77826	22	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	CHEMBL2105692	77826	22	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	57894063	74800	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036319	74800	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	156010583	176494	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4633041	176494	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	45271238	193958	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL556333	193958	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	59465587	144645	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	CHEMBL3912391	144645	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	11955315	143247	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3901088	143247	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11955256	142772	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3897181	142772	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	16725337	149057	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149057	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	16725337	149057	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149057	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443809	147601	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3935521	147601	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	89443631	148121	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3939716	148121	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	127050450	139757	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806076	139757	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	57395059	69116	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL1933725	69116	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	44229605	176070	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4470479	176070	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598070	176070	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443989	148124	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3939740	148124	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	44444714	93691	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249341	93691	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465588	142982	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3898887	142982	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465575	144522	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	CHEMBL3911438	144522	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	59465595	144878	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	CHEMBL3914108	144878	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	59465592	149158	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3947785	149158	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	59465590	150400	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3957958	150400	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465584	150886	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	CHEMBL3961847	150886	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	11855325	144146	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11955233	145048	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3915426	145048	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	11855593	146289	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL3924987	146289	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	89444078	145529	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3919144	145529	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	11955406	145559	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3919393	145559	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11955294	144223	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3909111	144223	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	44303889	201517	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64423	201517	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	11955179	145937	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922332	145937	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	11855588	146812	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146812	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	126495432	138781	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3792668	138781	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515517	147538	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3934986	147538	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	56839343	143735	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	CHEMBL3904989	143735	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	45266955	193962	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	CHEMBL556416	193962	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	57564500	150666	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	150666	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44303723	201237	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62885	201237	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	45269576	194299	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559820	194299	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	9863804	93651	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249136	93651	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	89444271	151364	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3966050	151364	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	53259983	175717	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4587628	175717	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595199	175717	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	2720	3781	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	5820	3781	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	6918140	3781	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	CHEMBL1237119	3781	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	DB00374	3781	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	127052577	139717	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805596	139717	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	67082722	164065	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4216182	164065	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	8541	2888	1	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	2888	1	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	2888	1	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	155527947	175950	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4460294	175950	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597099	175950	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	11955157	152099	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3972401	152099	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	56649302	152122	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3972583	152122	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	155539238	175897	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4514124	175897	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596631	175897	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	71516449	148892	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3945923	148892	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	127050766	139670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805075	139670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443614	150044	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3955120	150044	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	127052613	139663	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3804978	139663	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11955236	145911	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3922121	145911	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44303711	101869	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL303763	101869	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	67245477	144338	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	CHEMBL3909989	144338	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	24760055	143344	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143344	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	24760055	143344	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143344	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	89443736	150810	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3961188	150810	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	12521	2157	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	72722131	2157	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	CHEMBL3918816	2157	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	11955234	151673	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3968751	151673	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44230431	176069	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4531171	176069	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598069	176069	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	118517483	143727	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143727	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	11855590	143829	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143829	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855590	143829	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143829	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	134147021	149480	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	CHEMBL3950412	149480	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	11955255	145712	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920560	145712	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	92135977	152351	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152351	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	5819	995	27	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	673766	995	27	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	CHEMBL1578948	995	27	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	11855871	145863	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145863	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152435	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152435	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142249	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142249	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142249	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142249	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443779	148195	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3940318	148195	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	89443711	150435	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3958279	150435	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	118517483	143727	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143727	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	118517359	143851	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143851	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	118517488	153165	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153165	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	44442327	94010	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL251294	94010	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	11955358	152536	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3976116	152536	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	155521507	175865	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451941	175865	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596396	175865	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	56839342	148463	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3942394	148463	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	58932678	74923	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	CHEMBL2037290	74923	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	22246956	194635	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562291	194635	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	69753740	139679	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805134	139679	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	134155748	150625	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	150625	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89443669	146667	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	CHEMBL3928263	146667	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	89443662	152343	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3974557	152343	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	1883	3021	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3021	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3021	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3021	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3021	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3021	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	56835070	69113	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933722	69113	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56835070	69113	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL1933722	69113	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	51036042	175757	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4554216	175757	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595541	175757	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	66857975	163925	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4214346	163925	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	11955133	145104	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	CHEMBL3915820	145104	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	9820676	193365	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549461	193365	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	89444029	148550	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3943109	148550	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	122180297	121120	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586362	121120	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180261	121086	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586324	121086	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	122180274	121096	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586337	121096	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180288	121111	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586352	121111	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180250	121075	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586313	121075	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	122180267	121090	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586330	121090	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180251	121076	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586314	121076	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	122180273	121095	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586336	121095	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	1987175	3723	24	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	9283	3723	24	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	CHEMBL1372836	3723	24	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	122180270	121092	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586333	121092	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180282	121104	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586345	121104	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180295	121117	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586359	121117	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180296	121119	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586361	121119	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180265	121089	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586328	121089	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180276	121098	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586339	121098	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180289	121112	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586353	121112	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121118	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121118	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	30897313	121071	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121071	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	42484632	121072	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586310	121072	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	122180275	121097	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586338	121097	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180278	121100	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586341	121100	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180286	121108	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586349	121108	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121118	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121118	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180283	121105	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586346	121105	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180280	121102	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586343	121102	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180263	121087	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586326	121087	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121118	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121118	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180252	121077	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586315	121077	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	122180284	121106	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586347	121106	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121071	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121071	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121071	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121071	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180272	121094	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586335	121094	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180279	121101	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586342	121101	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180249	121074	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586312	121074	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	30956824	121073	3	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586311	121073	3	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	122180277	121099	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586340	121099	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44365207	40440	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL148449	40440	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	38191	9805	15	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL114395	9805	15	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	44365227	121459	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL359231	121459	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	1924	3473	33	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	9933831	3473	33	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	CHEMBL358653	3473	33	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	119461	317	66	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	1896	317	66	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	CHEMBL1317823	317	66	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	9817405	164840	2	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	CHEMBL423815	164840	2	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	10402929	57224	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	CHEMBL166351	57224	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	44377464	119567	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	CHEMBL350832	119567	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	9817292	56916	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	CHEMBL165010	56916	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	10483360	197539	21	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	CHEMBL589973	197539	21	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	138	3020	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3020	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3020	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3020	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3020	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	44230999	166875	20	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	CHEMBL4297666	166875	20	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	1929	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	1569	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	1883	3021	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3021	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3021	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3021	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3021	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3021	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1929	1569	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	1569	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	1569	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	1569	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	18376177	3684	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	3684	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	3684	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	3684	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	18376177	3684	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	3684	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	3684	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	3684	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	12520	3725	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	12520	3725	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	155128767	3725	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	155128767	3725	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	10603	3721	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	145996528	3721	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	CHEMBL4552900	3721	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	1987175	3723	24	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	9283	3723	24	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	CHEMBL1372836	3723	24	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	25114442	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	25114442	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	5817	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	CHEMBL3286797	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	DB12024	3000	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	25114442	3000	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	3000	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	3000	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	3000	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	46213069	3002	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8538	3002	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8546	3724	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	91827368	3724	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	5818	3722	42	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	5886965	3722	42	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	CHEMBL1368005	3722	42	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11855868	152000	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152000	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	127037150	137022	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3754586	137022	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	16725337	149057	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149057	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	59554827	136756	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752377	136756	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	11502897	142249	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142249	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855865	152731	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152731	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145735	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145735	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	1932	2886	4	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	5311228	2886	4	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	CHEMBL3286796	2886	4	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	90054482	143373	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3902065	143373	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	90054490	151646	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3968443	151646	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	127051063	139779	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806284	139779	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	11855590	143829	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143829	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	90054450	143232	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3900979	143232	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	11855591	143891	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143891	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	72948479	152487	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3975743	152487	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	70667255	150930	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	150930	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	90054430	148820	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3945327	148820	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	5283056	201163	26	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
	CHEMBL62570	201163	26	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
	66858111	136913	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753622	136913	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	72950425	142506	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	CHEMBL3895047	142506	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	11328569	136930	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753788	136930	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	11855324	142061	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	72950929	146037	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	CHEMBL3923027	146037	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	1883	3021	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	1916	3021	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5280360	3021	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	913	3021	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	CHEMBL548	3021	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	DB00917	3021	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	126495400	138778	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3792632	138778	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	127026955	138907	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794016	138907	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	18376177	3684	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	5816	3684	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	CHEMBL2107783	3684	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	DB12623	3684	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	11294085	136715	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3751951	136715	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
	59554822	136856	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753221	136856	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127051062	139731	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805767	139731	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	72950089	150046	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
	CHEMBL3955128	150046	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
	66857670	136863	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753268	136863	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	57529188	146650	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146650	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855866	144057	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144057	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	144146	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855324	142061	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	127026652	136944	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753898	136944	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127026956	138883	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793862	138883	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	9807448	201473	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	CHEMBL64246	201473	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	11855867	145438	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145438	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	1892	734	15	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	25886893	734	15	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	CHEMBL1628262	734	15	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	72948663	145189	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3916499	145189	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	5311035	97341	27	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	CHEMBL271896	97341	27	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	1883	3021	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	1916	3021	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	5280360	3021	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	913	3021	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	CHEMBL548	3021	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	DB00917	3021	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	66857738	136763	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752435	136763	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127050451	139678	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805122	139678	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	1929	1569	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	9890801	1569	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	CHEMBL563646	1569	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	DB12022	1569	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	11362836	136759	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752406	136759	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	11855325	144146	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855593	146289	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL3924987	146289	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	11855588	146812	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146812	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	5283086	201610	19	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL64804	201610	19	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	11156167	136982	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3754197	136982	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	90054537	147859	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3937596	147859	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	127051656	139751	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805981	139751	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	59554824	136937	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753853	136937	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	90054519	151442	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3966743	151442	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	72948294	149413	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3949856	149413	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	90054392	142374	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3893847	142374	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	11855871	145863	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145863	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152435	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152435	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127027874	138820	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793045	138820	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	127027874	138820	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793045	138820	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	10339756	142541	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL3895324	142541	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	118689427	151308	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	CHEMBL3965497	151308	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	56927669	121118	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121118	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	56927669	121118	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121118	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	10315	2870	20	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	44230575	2870	20	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	CHEMBL3707245	2870	20	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	122180251	121076	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586314	121076	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	122180259	121084	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586322	121084	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180261	121086	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586324	121086	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	122180282	121104	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586345	121104	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121071	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121071	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121071	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121071	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180253	121078	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586316	121078	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
	122180271	121093	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586334	121093	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44564990	192039	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL521777	192039	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
	122180276	121098	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586339	121098	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180285	121107	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586348	121107	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	44409693	165534	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
	CHEMBL425950	165534	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
	122180269	121091	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586332	121091	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44409907	76682	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL207237	76682	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
	44570000	178064	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	CHEMBL467632	178064	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	44409739	139117	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL379785	139117	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	44157014	192007	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL521609	192007	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
	58905349	155725	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4065183	155725	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4552554	212238	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2	ChEMBL		None	None	None		O=C(c1ccc(F)cc1)N1CC(COc2ccc(Br)cc2)(C(=O)O)C1	nan
	10047541	131976	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
	CHEMBL369797	131976	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
	122180293	121116	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586357	121116	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11955294	144223	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3909111	144223	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	11955240	147445	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3934202	147445	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
	44409910	140365	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL382197	140365	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
	25195248	182343	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	CHEMBL479263	182343	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	118756024	121110	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586350	121110	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180286	121108	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586349	121108	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	10339756	142541	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL3895324	142541	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	122180264	121088	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586327	121088	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180267	121090	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586330	121090	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11955255	145712	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920560	145712	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11495634	14721	7	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	CHEMBL1207972	14721	7	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	CHEMBL467114	14721	7	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	9820676	193365	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549461	193365	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180290	121113	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586354	121113	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	11575201	156868	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4078648	156868	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	72695027	105772	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3115074	105772	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3138992	105772	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	122180256	121081	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586319	121081	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	11955406	145559	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3919393	145559	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44409738	139063	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL379746	139063	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
	11577792	158759	15	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4099851	158759	15	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	46879894	6089	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
	CHEMBL1081186	6089	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
	122180297	121120	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586362	121120	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	1883	3021	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	1916	3021	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	5280360	3021	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	913	3021	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	CHEMBL548	3021	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	DB00917	3021	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	1883	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	1916	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	5280360	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	913	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	CHEMBL548	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	DB00917	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	1883	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	1916	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	5280360	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	913	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	CHEMBL548	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	DB00917	3021	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	122180249	121074	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586312	121074	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	122180295	121117	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586359	121117	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	30956824	121073	3	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586311	121073	3	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	122180250	121075	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586313	121075	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	122180252	121077	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586315	121077	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	122180288	121111	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586352	121111	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	9885481	193703	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL551951	193703	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	11955276	150206	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	CHEMBL3956391	150206	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	44570666	182678	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	CHEMBL479664	182678	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	58905388	158108	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4092846	158108	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	10670992	59726	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
	CHEMBL173680	59726	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
	15486806	100008	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
	CHEMBL290969	100008	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
	45270403	193437	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL550015	193437	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	10180	3522	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	49843471	3522	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	CHEMBL2386081	3522	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	DB12562	3522	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	45271237	193419	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549870	193419	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180275	121097	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586338	121097	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	71733910	89890	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2385900	89890	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	18376258	194218	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559065	194218	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	122180263	121087	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586326	121087	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246983	194179	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL558671	194179	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	1883	3021	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	1916	3021	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	5280360	3021	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	913	3021	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	CHEMBL548	3021	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	DB00917	3021	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	122180284	121106	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586347	121106	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180265	121089	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586328	121089	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180274	121096	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586337	121096	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180254	121079	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586317	121079	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180255	121080	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586318	121080	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180260	121085	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586323	121085	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
	45269575	194721	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562825	194721	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	45271234	193403	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549663	193403	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	45268716	194314	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559955	194314	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	16664733	154277	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
	CHEMBL400404	154277	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
	45266955	193962	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	CHEMBL556416	193962	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	44627515	195152	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
	CHEMBL565799	195152	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
	11618662	158264	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4094572	158264	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	11955257	153340	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3983069	153340	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	1883	3021	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	1916	3021	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	5280360	3021	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	913	3021	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	CHEMBL548	3021	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	DB00917	3021	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	1894	941	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	5311053	941	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	CHEMBL37853	941	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	DB11507	941	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	118175009	136149	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	CHEMBL3740325	136149	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	45271238	193958	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL556333	193958	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	1883	3021	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	1916	3021	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	5280360	3021	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	913	3021	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	CHEMBL548	3021	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	DB00917	3021	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	122180272	121094	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586335	121094	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180278	121100	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586341	121100	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180292	121115	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
	CHEMBL3586356	121115	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
	11296282	1377	22	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	5822	1377	22	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	CHEMBL565591	1377	22	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	44230999	166875	20	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4297666	166875	20	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11955235	152207	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3973312	152207	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44564571	186223	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL489310	186223	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	11683088	158420	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4096216	158420	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	162671048	182215	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
	CHEMBL4790821	182215	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
	9934368	138379	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
	CHEMBL378376	138379	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
	9934368	138379	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL378376	138379	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
	44627395	195187	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	CHEMBL565992	195187	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	11955410	151985	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3971493	151985	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
	5311239	130083	22	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
	CHEMBL36817	130083	22	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
	45268715	194292	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559760	194292	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	25114442	3000	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	5817	3000	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	CHEMBL3286797	3000	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	DB12024	3000	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	1883	3021	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1916	3021	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	5280360	3021	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	913	3021	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	CHEMBL548	3021	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	DB00917	3021	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1929	1569	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	9890801	1569	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	CHEMBL563646	1569	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	DB12022	1569	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	22246895	193881	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL554823	193881	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	18376196	193243	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541516	193243	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	58681352	153793	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	CHEMBL3986829	153793	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	122180281	121103	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586344	121103	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	16048029	193822	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL553468	193822	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180277	121099	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586340	121099	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180257	121082	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586320	121082	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	122180258	121083	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586321	121083	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180291	121114	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586355	121114	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	11955358	152536	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3976116	152536	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	18376082	193244	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541517	193244	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	22246956	194635	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562291	194635	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44409917	138707	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL378968	138707	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
	122180273	121095	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586336	121095	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11539410	89894	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
	CHEMBL2385904	89894	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
	45269576	194299	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559820	194299	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11653874	89914	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2386079	89914	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	1955	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	5311240	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	CHEMBL36041	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	44409733	140340	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL382029	140340	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	30897313	121071	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121071	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	42484632	121072	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586310	121072	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	122180270	121092	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586333	121092	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246893	194268	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559561	194268	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11524454	931	52	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	5857	931	52	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	CHEMBL591666	931	52	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	68505327	89915	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2386080	89915	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	44564892	179930	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL475348	179930	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	10126807	193418	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549869	193418	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	56927669	121118	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121118	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180296	121119	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586361	121119	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180279	121101	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586342	121101	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180289	121112	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586353	121112	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180280	121102	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586343	121102	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246765	193518	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL550619	193518	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44409918	165409	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL425243	165409	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
	11955236	145911	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3922121	145911	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	122180283	121105	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586346	121105	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	45268713	194267	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL559560	194267	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	10223499	194657	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562411	194657	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44564893	179931	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL475349	179931	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	71733912	89893	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2385903	89893	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
	44564804	176116	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL459885	176116	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	25114442	3000	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	5817	3000	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	CHEMBL3286797	3000	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	DB12024	3000	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	9807448	201473	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	201473	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	1883	3021	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3021	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3021	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3021	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3021	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3021	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	51039069	128668	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
	CHEMBL3670659	128668	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
	51039071	128672	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
	CHEMBL3670663	128672	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
	10481859	74802	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	CHEMBL2036321	74802	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	1932	2886	4	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	5311228	2886	4	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	CHEMBL3286796	2886	4	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	1883	3021	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	1916	3021	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	5280360	3021	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	913	3021	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	CHEMBL548	3021	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	DB00917	3021	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	57384034	70948	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957436	70948	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	57384034	70948	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957436	70948	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	67078793	128662	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
	CHEMBL3670653	128662	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
	18376177	3684	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	5816	3684	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	CHEMBL2107783	3684	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	DB12623	3684	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	11855865	152731	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152731	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	10116114	125352	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL364841	125352	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	13231966	100471	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL294108	100471	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	13231966	100471	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL294108	100471	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44455046	95270	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL258332	95270	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	44304057	201559	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64598	201559	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	10181606	204618	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	CHEMBL87371	204618	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	118517483	143727	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143727	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	71455094	81455	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	CHEMBL2164609	81455	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	44303627	201506	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64358	201506	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	5311035	97341	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL271896	97341	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
	52941778	16350	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237304	16350	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
	5311035	97341	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL271896	97341	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
	44390782	64257	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL181691	64257	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44303907	201044	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL61925	201044	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10431288	69009	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929546	69009	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	46201043	198888	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL599154	198888	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	9939791	161357	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	CHEMBL415310	161357	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	9873528	205193	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL91063	205193	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
	134155748	150625	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	150625	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11502897	142249	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142249	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142249	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142249	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	119461	317	66	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	1896	317	66	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	CHEMBL1317823	317	66	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	118517359	143851	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143851	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	24952927	199536	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
	CHEMBL603690	199536	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
	44304404	100102	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL291630	100102	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	10291963	84270	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL222715	84270	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	44520989	198072	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
	CHEMBL593764	198072	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
	23016719	199525	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL603625	199525	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	44304055	102237	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL304887	102237	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44304034	198900	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	CHEMBL59921	198900	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	9817405	164840	2	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
	CHEMBL423815	164840	2	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
	72695027	105772	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3115074	105772	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3138992	105772	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	72706947	174082	15	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL4558749	174082	15	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	118517488	153165	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153165	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	44442327	94010	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251294	94010	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	17757350	152210	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152210	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	10112412	69110	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933719	69110	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	10112412	69110	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933719	69110	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	118517489	143147	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143147	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	51039070	128669	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670660	128669	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
	44303626	167608	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL433249	167608	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	57400249	69119	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933728	69119	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
	10291963	84270	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	CHEMBL222715	84270	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	11315933	122765	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL361457	122765	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	44394432	126791	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365908	126791	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	23017109	198381	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595830	198381	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	15907747	205285	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	CHEMBL91537	205285	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	118517361	152824	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152824	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	9975502	94040	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251504	94040	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	3356	2239	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	4326	2239	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	9867642	2239	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	CHEMBL426559	2239	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	DB11629	2239	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	70667255	150930	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	150930	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	24760052	150641	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	150641	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	44304436	201620	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64854	201620	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44320373	204517	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
	CHEMBL86799	204517	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
	52947851	16353	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237315	16353	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
	52947851	16353	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237315	16353	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	9813912	137343	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL376282	137343	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	57394140	69014	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929550	69014	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	134146425	148659	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3943966	148659	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11519006	102000	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	CHEMBL2373410	102000	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	CHEMBL3040272	102000	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	9808508	111059	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL328067	111059	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	44455115	95105	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257658	95105	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	118517359	143851	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143851	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	44289922	162960	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL42027	162960	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	11855868	152000	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152000	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	57393340	69117	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933726	69117	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
	11855868	152000	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152000	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	57894053	74805	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036324	74805	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	155516303	169499	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4443289	169499	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	18973764	16453	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
	CHEMBL124199	16453	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
	44304058	201478	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64254	201478	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
	23017216	197470	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL589411	197470	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	44304051	102274	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	CHEMBL305126	102274	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	134143292	144683	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3912658	144683	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465595	144878	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	CHEMBL3914108	144878	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	59465574	145400	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	CHEMBL3918084	145400	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	118517490	152609	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	152609	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	72695027	105772	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	CHEMBL3115074	105772	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	CHEMBL3138992	105772	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	72695027	105772	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	CHEMBL3115074	105772	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	CHEMBL3138992	105772	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	24952577	198867	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL599051	198867	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	1929	1569	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	9890801	1569	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	CHEMBL563646	1569	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	DB12022	1569	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	44349503	167815	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	CHEMBL434637	167815	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	44419351	83714	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL220821	83714	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	44324368	96058	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL262690	96058	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10144273	204109	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL83450	204109	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11855871	145863	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145863	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	145863	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145863	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	144057	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144057	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	144057	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144057	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	53494965	64467	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
	CHEMBL1819611	64467	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
	52947847	16346	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237300	16346	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	11314979	65763	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL183933	65763	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	11234840	124522	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
	CHEMBL364421	124522	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
	56949973	69015	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929551	69015	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	57894092	74793	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036312	74793	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	10157810	63441	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
	CHEMBL180191	63441	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
	44442334	94079	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251710	94079	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11495634	14721	7	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	CHEMBL1207972	14721	7	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	CHEMBL467114	14721	7	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	92135977	152351	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152351	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	52945421	16344	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237298	16344	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
	21362912	170599	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL445895	170599	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	23017362	198285	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595157	198285	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	11577792	158759	15	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4099851	158759	15	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	10448293	153875	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398947	153875	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11855324	142061	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57395059	69116	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933725	69116	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
	57395059	69116	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1933725	69116	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
	11855865	152731	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152731	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57403612	70946	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
	CHEMBL1957434	70946	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
	15948325	2480	39	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	5856	2480	39	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	CHEMBL402162	2480	39	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	59465577	142645	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896183	142645	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	57893982	74799	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036318	74799	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	57464006	74803	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036322	74803	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	9807448	201473	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	201473	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	67078538	128663	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
	CHEMBL3670654	128663	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
	44303952	100406	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293697	100406	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10361472	64862	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL182555	64862	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
	10118889	204540	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL86933	204540	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11187675	64868	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL182572	64868	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	12002527	74795	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036314	74795	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	24953628	198909	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
	CHEMBL599262	198909	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
	57529188	146650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57529188	146650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146650	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44444721	153860	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL398827	153860	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	44455084	97405	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL272277	97405	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	58932681	74807	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036326	74807	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	10116116	64065	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813115	64065	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10206535	66224	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL185251	66224	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44320126	204676	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87816	204676	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	22009011	63727	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL180742	63727	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	11187675	64868	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL182572	64868	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	44419380	82652	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218178	82652	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	44419384	82653	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218179	82653	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	57894081	74789	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036308	74789	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
	23017746	198157	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL594365	198157	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	9846782	100425	4	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL293856	100425	4	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	15907748	110963	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL327597	110963	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	138	3020	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1882	3020	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	5280723	3020	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL495	3020	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	DB00770	3020	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1883	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	1916	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	5280360	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	913	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	CHEMBL548	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	DB00917	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	1883	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	1916	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	5280360	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	913	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	CHEMBL548	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	DB00917	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	57396660	70949	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957437	70949	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
	57396660	70949	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957437	70949	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
	10348321	74806	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036325	74806	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	58932678	74923	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	CHEMBL2037290	74923	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	56672020	64479	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819623	64479	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	11337782	84505	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	CHEMBL223744	84505	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	9863804	93651	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249136	93651	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	9938669	167484	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL432380	167484	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10113454	176917	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL46395	176917	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	118517483	143727	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143727	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	11488860	19080	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
	CHEMBL1290413	19080	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
	24760055	143344	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143344	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	24760055	143344	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143344	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	11855591	143891	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143891	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	11855591	143891	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143891	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	10414412	74801	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036320	74801	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
	11408533	140783	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	CHEMBL383484	140783	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	11408533	140783	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL383484	140783	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	11743212	16967	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125588	16967	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	56658143	64459	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819604	64459	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	9809136	106393	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL314533	106393	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	9874010	205451	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL92539	205451	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10229201	155024	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404414	155024	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	10076580	74924	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037291	74924	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	132836	59368	20	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
	CHEMBL1722929	59368	20	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
	57403799	69111	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933720	69111	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
	57403799	69111	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933720	69111	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
	5311035	97341	27	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	CHEMBL271896	97341	27	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	44303980	167500	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL432522	167500	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	22009004	141207	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
	CHEMBL385955	141207	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
	10270893	93780	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249954	93780	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	44303889	201517	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64423	201517	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	17751059	147724	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	147724	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	21974328	65923	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL184684	65923	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	10228100	64068	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813118	64068	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	44349551	16620	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124675	16620	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10158725	16634	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124738	16634	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	44320405	105672	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL313700	105672	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
	52944194	16351	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL1237305	16351	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	52947852	16354	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237316	16354	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
	52947852	16354	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237316	16354	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	44419388	82988	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL219590	82988	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	11339240	84290	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	CHEMBL222834	84290	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	9885106	84335	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
	CHEMBL223151	84335	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
	9885106	84335	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
	CHEMBL223151	84335	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
	44304258	101873	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL303787	101873	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	44455158	97259	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL271488	97259	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	9821171	97404	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL272276	97404	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	44304011	201111	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL62305	201111	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	44290263	100846	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL296715	100846	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
	77050677	128049	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
	CHEMBL3667607	128049	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
	11855325	144146	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	21362900	204115	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL83518	204115	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11418818	66314	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185369	66314	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	53358921	64095	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
	CHEMBL1813287	64095	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
	10181606	204618	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL87371	204618	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	118517360	143431	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	CHEMBL3902700	143431	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	44444714	93691	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249341	93691	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	57893848	74804	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036323	74804	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	21974362	121517	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL359564	121517	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
	9886718	201464	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64217	201464	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	118175009	136149	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	CHEMBL3740325	136149	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	10157813	199921	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL605833	199921	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	59465587	144645	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	CHEMBL3912391	144645	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	10205205	93721	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249539	93721	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	10089562	153876	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398948	153876	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44304335	201280	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	CHEMBL63061	201280	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	21362879	16376	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
	CHEMBL123855	16376	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
	21362853	18331	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL127482	18331	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	12112239	106065	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL314200	106065	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	21362893	204594	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87263	204594	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	44320321	204698	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87975	204698	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	52941777	16348	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237302	16348	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44393681	66512	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL186244	66512	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	10202765	172108	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL45008	172108	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	71458758	120336	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	CHEMBL2164612	120336	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	CHEMBL3558858	120336	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	57396825	69115	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933724	69115	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
	57396825	69115	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
	CHEMBL1933724	69115	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
	57394893	70947	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957435	70947	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	57394893	70947	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957435	70947	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	51039072	128671	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
	CHEMBL3670662	128671	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
	9807448	201473	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	CHEMBL64246	201473	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	67078580	128665	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	CHEMBL3670656	128665	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	51039068	128667	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	CHEMBL3670658	128667	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	44304164	201534	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64483	201534	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	15947857	154963	8	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
	CHEMBL404199	154963	8	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
	44320294	105514	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL313266	105514	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	230826	92985	27	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
	CHEMBL245908	92985	27	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
	44269516	43371	24	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL15096	43371	24	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	10413147	8977	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	CHEMBL1099047	8977	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	44444720	93779	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249953	93779	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	11855870	145735	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145735	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145735	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145735	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11269563	141066	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL385126	141066	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	10185382	64069	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813119	64069	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	9867899	201425	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL64072	201425	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44303590	201213	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL62779	201213	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	21362867	106605	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL315974	106605	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
	44269544	35011	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
	CHEMBL14359	35011	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
	118517488	153165	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153165	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	118517361	152824	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152824	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	57393339	69114	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933723	69114	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	57393339	69114	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933723	69114	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	44290312	178332	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL47018	178332	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
	72950089	150046	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL3955128	150046	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	21974331	126012	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365243	126012	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	10363130	100553	0	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL294585	100553	0	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10185612	64067	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813117	64067	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	11338015	65772	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL183983	65772	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	44303967	201260	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62987	201260	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
	10294290	198360	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595632	198360	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	50898361	56563	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
	CHEMBL1644003	56563	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
	44304474	201233	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL62868	201233	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
	10277744	64066	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813116	64066	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10291963	84270	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
	CHEMBL222715	84270	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
	11476788	160715	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
	CHEMBL412070	160715	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
	92135977	152351	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152351	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	11405770	137369	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	CHEMBL376347	137369	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	21362910	16729	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125269	16729	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	57893867	74792	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036311	74792	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
	56658144	64460	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819605	64460	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	44349531	16373	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL123844	16373	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	21362849	167754	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	CHEMBL434247	167754	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	44269464	34239	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL14286	34239	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	118517489	143147	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143147	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	44304417	200416	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL60894	200416	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44303723	201237	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62885	201237	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	53358922	64084	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	CHEMBL1813276	64084	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	21362851	116391	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL338388	116391	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10109445	84705	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
	CHEMBL224970	84705	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
	1883	3021	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	1916	3021	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5280360	3021	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	913	3021	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	CHEMBL548	3021	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	DB00917	3021	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5283086	201610	19	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL64804	201610	19	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	10271490	165329	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL424975	165329	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44320433	167369	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL431612	167369	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	24953283	197757	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL591431	197757	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	11855594	152435	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152435	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152435	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152435	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11294166	76677	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	CHEMBL207203	76677	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	11294166	76677	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL207203	76677	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	22009003	122088	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL360290	122088	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	44304008	201542	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
	CHEMBL64542	201542	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
	44138108	183693	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	CHEMBL483991	183693	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	51039064	128666	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670657	128666	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	1883	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	1916	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	5280360	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	913	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	CHEMBL548	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	DB00917	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	1883	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	1916	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	5280360	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	913	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	CHEMBL548	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	DB00917	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	1883	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	1916	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	5280360	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	913	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	CHEMBL548	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	DB00917	3021	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	44304124	102137	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL304225	102137	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	11855324	142061	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855324	142061	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142061	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44269486	166278	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL428524	166278	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	138	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1882	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	5280723	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL495	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	DB00770	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	138	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	1882	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	5280723	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL495	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	DB00770	3020	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	10183680	126632	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365696	126632	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	11597294	165612	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
	CHEMBL426387	165612	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
	57391585	69109	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933718	69109	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
	57391585	69109	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933718	69109	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
	10112486	16706	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
	CHEMBL125110	16706	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
	44390831	63291	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180089	63291	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
	44289969	100895	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
	CHEMBL297139	100895	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
	57398586	69118	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933727	69118	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
	44290262	177934	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL46671	177934	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
	44290272	100960	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL297578	100960	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
	44442327	94010	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL251294	94010	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	71462285	81454	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	CHEMBL2164608	81454	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	44303711	101869	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL303763	101869	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	24953285	199175	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
	CHEMBL601299	199175	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
	155520370	169898	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4448995	169898	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	56665068	64478	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819622	64478	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	10269242	155023	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404413	155023	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	21974528	123918	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL363984	123918	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44289922	162960	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
	CHEMBL42027	162960	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
	10227492	16703	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125087	16703	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
	44349528	113289	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL332446	113289	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	59465601	149350	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3949271	149350	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	24953286	199689	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
	CHEMBL604546	199689	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
	54013831	145915	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3922151	145915	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	9845064	68991	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929528	68991	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	11395329	123316	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL362541	123316	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	9885106	84335	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
	CHEMBL223151	84335	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
	44304389	201454	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL64188	201454	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
	10168694	204616	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL87366	204616	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	12521	2157	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	72722131	2157	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	CHEMBL3918816	2157	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	1929	1569	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	9890801	1569	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	CHEMBL563646	1569	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	DB12022	1569	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	10299717	64071	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
	CHEMBL1813120	64071	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
	59465588	142982	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3898887	142982	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465575	144522	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	CHEMBL3911438	144522	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	59465592	149158	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3947785	149158	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	59465590	150400	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3957958	150400	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465584	150886	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	CHEMBL3961847	150886	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	11855325	144146	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	144146	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144146	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57564500	150666	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	150666	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	12137443	84265	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	CHEMBL222677	84265	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	11224239	64458	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819603	64458	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	11282034	66282	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185277	66282	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	46887240	8651	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	CHEMBL1096382	8651	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	52945419	16342	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237296	16342	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	56672018	64461	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819606	64461	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	44303709	201501	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL64338	201501	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	59465581	143568	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	143568	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	44455236	95018	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257217	95018	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	21974448	66614	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL186735	66614	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	11155228	65760	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL183919	65760	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	44419347	82349	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL217988	82349	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	10298293	93720	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249538	93720	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	52944193	16341	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237295	16341	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	21362905	170731	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	CHEMBL446098	170731	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	58932683	74922	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037289	74922	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	44444716	154287	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
	CHEMBL400447	154287	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
	10295421	93750	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249744	93750	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
	44234032	147380	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
	CHEMBL3933704	147380	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
	11165749	165395	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL425167	165395	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	44520990	198161	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	CHEMBL594423	198161	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	11855867	145438	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145438	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855867	145438	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145438	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44304403	168520	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL439934	168520	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44290314	173392	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
	CHEMBL45418	173392	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
	44320272	204529	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL86886	204529	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	24952929	2507	37	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	4041	2507	37	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	CHEMBL597997	2507	37	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	10295336	199751	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL604897	199751	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	44290266	161147	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
	CHEMBL413509	161147	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
	44394380	124896	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL364593	124896	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44442337	93560	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
	CHEMBL248678	93560	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
	44442331	94041	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251505	94041	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	10278907	64072	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	CHEMBL1813121	64072	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	59465570	142715	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896693	142715	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	134147021	149480	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	CHEMBL3950412	149480	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	10204257	93722	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249540	93722	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	44219292	112077	30	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	CHEMBL3301604	112077	30	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	57400087	70943	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957431	70943	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
	57893916	74790	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036309	74790	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
	56672019	64468	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
	CHEMBL1819612	64468	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
	8541	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	9824353	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL292964	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	8541	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	9824353	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	CHEMBL292964	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	8541	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	9824353	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	CHEMBL292964	2888	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	10221497	93692	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249342	93692	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	10272306	154286	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL400446	154286	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
	71452690	78200	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
	CHEMBL2112332	78200	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
	52950151	16345	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237299	16345	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	22008967	82722	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218228	82722	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	22008966	82723	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218229	82723	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	13230981	34826	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL14334	34826	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	10348006	74925	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2037292	74925	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	52943000	16343	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237297	16343	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	10319835	69010	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929547	69010	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	44520991	198010	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	CHEMBL593260	198010	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	44289977	162197	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL417171	162197	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	12003887	70940	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957308	70940	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
	67078970	128664	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670655	128664	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	59465571	145740	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920796	145740	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	59465600	151154	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3964261	151154	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	21362845	106407	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL314616	106407	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	52943002	16347	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237301	16347	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	67245477	144338	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	CHEMBL3909989	144338	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	44289921	163808	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
	CHEMBL42129	163808	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
	57893891	74794	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036313	74794	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
	24952929	2507	37	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	4041	2507	37	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	CHEMBL597997	2507	37	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	1892	734	15	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	25886893	734	15	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	CHEMBL1628262	734	15	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	44304181	201573	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64663	201573	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9965922	63531	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
	CHEMBL180389	63531	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
	24765153	183937	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	CHEMBL484778	183937	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	9910141	100395	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	CHEMBL293647	100395	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	118517485	142206	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	142206	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	24952580	198868	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL599052	198868	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	10452108	93561	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
	CHEMBL248679	93561	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
	44304388	201453	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL64187	201453	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	11440167	84280	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	CHEMBL222782	84280	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	44444722	93808	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL250153	93808	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	52945294	16355	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237317	16355	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	52945294	16355	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237317	16355	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	10111602	82801	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218626	82801	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	22990263	16599	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124574	16599	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
	10410111	102355	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL305568	102355	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	44304009	100255	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL292717	100255	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	11210487	63948	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL181035	63948	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	16725337	149057	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149057	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	16725337	149057	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149057	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	24953625	199837	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
	CHEMBL605330	199837	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
	10302378	82353	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL217991	82353	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	22009006	141020	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL384878	141020	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	9953337	141116	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL385396	141116	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	25003075	6745	12	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
	CHEMBL1084009	6745	12	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
	10247632	77622	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL2096894	77622	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	10178073	16367	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
	CHEMBL123794	16367	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
	9944231	17836	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL126472	17836	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10178073	16367	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL123794	16367	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	12112238	117555	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL340501	117555	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	44444715	93751	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249745	93751	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
	57398585	69112	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933721	69112	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	57398585	69112	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933721	69112	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56834112	68990	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929527	68990	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	44290271	178460	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL47138	178460	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
	52944193	16341	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237295	16341	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44419374	82568	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218123	82568	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	44419379	137325	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL376053	137325	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	44320388	204672	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87797	204672	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	9954562	83708	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL220802	83708	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	138	3020	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	1882	3020	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	5280723	3020	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL495	3020	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	DB00770	3020	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	52945423	16349	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237303	16349	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
	22009008	82730	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218280	82730	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	22009004	141207	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL385955	141207	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	132836	59368	20	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL1722929	59368	20	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44442332	94078	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251709	94078	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44393680	65998	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185087	65998	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	84973026	128673	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
	CHEMBL3670664	128673	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
	57894063	74800	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036319	74800	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	56835070	69113	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933722	69113	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	56835070	69113	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933722	69113	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56835070	69113	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL1933722	69113	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	84973025	128670	3	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
	CHEMBL3670661	128670	3	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
	21974374	126712	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365829	126712	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44304334	199881	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL60555	199881	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	57396659	70942	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957430	70942	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	44304199	100337	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293242	100337	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	44444719	93778	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249952	93778	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	10273914	197980	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL593041	197980	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	46230201	198922	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL599355	198922	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	118517485	142206	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	142206	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	118517490	152609	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	152609	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	9865111	63519	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180343	63519	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44419350	83713	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL220820	83713	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
	118517359	143851	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143851	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	10116114	125352	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL364841	125352	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10116114	125352	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
	CHEMBL364841	125352	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
	44390806	63732	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180752	63732	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	1883	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1883	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1916	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1916	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	5280360	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	5280360	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	913	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	913	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	CHEMBL548	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	CHEMBL548	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	DB00917	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	DB00917	3021	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1883	3021	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	1916	3021	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	5280360	3021	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	913	3021	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	CHEMBL548	3021	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	DB00917	3021	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	1883	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	1883	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	1916	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	1916	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	5280360	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	5280360	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	913	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	913	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	CHEMBL548	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	CHEMBL548	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	DB00917	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	DB00917	3021	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	138	3020	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3020	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3020	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3020	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3020	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	None	214265	0	3H-PGE2	-66	3	Mouse	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	350	11	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O	None
	5090	214636	0	Functional	-1348	31	Dog	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5090	214636	0	Functional	-35	31	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5311035	97341	27	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
	CHEMBL271896	97341	27	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
	1883	3021	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3021	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3021	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3021	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3021	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3021	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1917	912	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	5311044	912	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	631	912	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	CHEMBL160629	912	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	89077401	214263	0	3H-PGE2	-144	12	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	360	8	3	3	3.5	CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	133126726	214264	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	24868263	214264	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	1440	1988	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1988	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1988	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1988	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1988	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	None	214262	0	3H-PGE2	-9	5	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	366	12	2	3	5.2	CCCCCC(C=CC1CC2CC(C1CC=CCCCC(=O)O)S2)O	None
	None	214268	0	3H-PGE2	-2	3	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	512	11	2	4	4.6	C1CC2C(C(C1O2)CC=CCCCC(=O)O)C=CC(COC3=CC=C(C=C3)I)O	None
	1928	314	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
	5310998	314	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
	1817	2496	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1936	2496	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	5282381	2496	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	CHEMBL606	2496	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	DB00929	2496	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1440	1988	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1440	1988	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1988	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1988	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1988	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1988	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1988	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1988	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1988	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1988	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	119461	317	66	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	1896	317	66	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	CHEMBL1317823	317	66	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	5090	214636	0	Functional	-35	31	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5090	214636	0	Functional	-35	31	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5077	3509	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	7552	3509	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	9913767	3509	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	CHEMBL238804	3509	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	DB11362	3509	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	1884	3022	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	5280363	3022	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	912	3022	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	CHEMBL815	3022	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	DB12789	3022	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	138107701	186871	39	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	186871	39	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	186871	39	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	138107701	186871	39	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	186871	39	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	186871	39	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	1917	912	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	5311044	912	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	631	912	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	CHEMBL160629	912	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	138107701	186871	39	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	186871	39	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	186871	39	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	1884	3022	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	5280363	3022	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	912	3022	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	CHEMBL815	3022	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	DB12789	3022	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	656511	215978	0	None	-1	7	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	539	6	3	8	-0.2	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(C3=O)S(C)(=O)=O)C3=CC=CC=C3)C(=O)N2[C@H]1C(O)=O	None
	3356	2239	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	4326	2239	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	9867642	2239	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	CHEMBL426559	2239	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	DB11629	2239	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	123619	214634	0	None	125	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	5090	214636	0	None	28	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	1817	2496	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1936	2496	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	5282381	2496	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	CHEMBL606	2496	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	DB00929	2496	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	138	3020	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3020	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3020	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3020	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3020	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1883	3021	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3021	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3021	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3021	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3021	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3021	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1440	1988	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1988	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1988	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1988	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1988	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	138	3020	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3020	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3020	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3020	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3020	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	2720	3781	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	5820	3781	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	6918140	3781	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	CHEMBL1237119	3781	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	DB00374	3781	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	1883	3021	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3021	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3021	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3021	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3021	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3021	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5852	2569	47	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	9931891	2569	47	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	CHEMBL239226	2569	47	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	1895	1968	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	6435378	1968	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	CHEMBL236025	1968	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	DB01088	1968	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	1892	734	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	1892	734	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	25886893	734	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	25886893	734	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	CHEMBL1628262	734	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	CHEMBL1628262	734	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	1883	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	1883	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	1883	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	1916	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	1916	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	1916	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	5280360	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	5280360	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	5280360	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	913	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	913	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	913	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	CHEMBL548	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	CHEMBL548	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	CHEMBL548	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	DB00917	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	DB00917	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	DB00917	3021	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	1883	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	1883	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1883	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1916	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	1916	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1916	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	5280360	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	5280360	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	5280360	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	913	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	913	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	913	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	CHEMBL548	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	CHEMBL548	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	CHEMBL548	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	DB00917	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	DB00917	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	DB00917	3021	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	138	3020	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	138	3020	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1882	3020	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	1882	3020	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	5280723	3020	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	5280723	3020	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL495	3020	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	CHEMBL495	3020	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	DB00770	3020	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	DB00770	3020	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	138	3020	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	1882	3020	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	5280723	3020	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	CHEMBL495	3020	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	DB00770	3020	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	1883	3021	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	1916	3021	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	5280360	3021	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	913	3021	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	CHEMBL548	3021	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	DB00917	3021	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	10110	3026	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
	59654860	3026	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
	2720	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	2720	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	5820	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	5820	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	6918140	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	6918140	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	CHEMBL1237119	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	CHEMBL1237119	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	DB00374	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	DB00374	3781	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	10315	2870	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	44230575	2870	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	CHEMBL3707245	2870	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	1932	2886	4	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	5311228	2886	4	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	CHEMBL3286796	2886	4	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	1888	3825	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	1974	3825	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	5311493	3825	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	CHEMBL521784	3825	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	1817	2496	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	1936	2496	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	5282381	2496	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	CHEMBL606	2496	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	DB00929	2496	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	1881	3018	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1891	3018	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	448457	3018	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	CHEMBL1235252	3018	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	DB02056	3018	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1888	3825	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	1974	3825	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	5311493	3825	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	CHEMBL521784	3825	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	1881	3018	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1891	3018	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	448457	3018	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	CHEMBL1235252	3018	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	DB02056	3018	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1931	2890	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
	5311229	2890	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
	1884	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1884	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	5280363	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	5280363	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	912	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	912	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	CHEMBL815	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	CHEMBL815	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	DB12789	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	DB12789	3022	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	1884	3022	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	5280363	3022	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	912	3022	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	CHEMBL815	3022	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	DB12789	3022	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1913	2419	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
	1913	2419	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
	5311223	2419	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
	5311223	2419	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
	1895	1968	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	6435378	1968	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	CHEMBL236025	1968	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	DB01088	1968	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	1933	2887	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
	5311230	2887	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
	1893	781	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	5311242	781	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	CHEMBL148319	781	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	1895	1968	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	6435378	1968	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	CHEMBL236025	1968	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	DB01088	1968	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	1947	29	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
	5283038	29	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
	119461	317	66	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	1896	317	66	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	CHEMBL1317823	317	66	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	1917	912	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	5311044	912	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	631	912	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	CHEMBL160629	912	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	1913	2419	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
	5311223	2419	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
	1928	314	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
	5310998	314	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
	1893	781	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	5311242	781	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	CHEMBL148319	781	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	1934	2051	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	5311244	2051	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	CHEMBL4522827	2051	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	1912	27	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	5283068	27	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	CHEMBL1879970	27	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	1930	3269	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	9803828	3269	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	CHEMBL303960	3269	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	DB16315	3269	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	119461	317	66	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	1896	317	66	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	CHEMBL1317823	317	66	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	119461	317	66	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	1896	317	66	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	CHEMBL1317823	317	66	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	1928	314	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
	5310998	314	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
	1947	29	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
	5283038	29	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
	1892	734	15	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	25886893	734	15	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL1628262	734	15	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1925	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	5283055	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	CHEMBL3246389	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	1925	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	5283055	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL3246389	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1935	2495	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	6436406	2495	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	CHEMBL1201377	2495	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	1926	25	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
	5283066	25	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
	CHEMBL1221529	25	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)