Ligand source activities (1 row/activity)



Get vendors


Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
138107701 186871 39 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
5311181 186871 39 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
CHEMBL494 186871 39 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
138107701 186871 39 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186871 39 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186871 39 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
138 3020 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 3020 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 3020 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 3020 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 3020 84 None -16 9 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
2720 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
5820 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
6918140 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
CHEMBL1237119 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
DB00374 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
118727298 116897 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 116897 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
118727308 116907 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 116907 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235755 153162 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153162 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727301 116900 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 116900 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839344 151507 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
CHEMBL3967284 151507 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
137636847 155439 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL4061744 155439 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
118727293 116892 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 116892 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727305 116904 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398226 116904 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
127052613 139663 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3804978 139663 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727312 116911 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 116911 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727307 116906 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 116906 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727297 116896 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 116896 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727296 116895 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 116895 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234782 146727 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 146727 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727294 116893 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 116893 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
118727306 116905 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 116905 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 116894 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 116894 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235522 141976 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 141976 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 116901 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 116901 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 116908 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 116908 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727296 116895 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 116895 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44236221 147174 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147174 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
44235044 147040 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3930990 147040 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232565 153426 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153426 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235044 142319 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142319 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727311 116910 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 116910 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
126495507 138836 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793167 138836 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727292 116891 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398213 116891 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727313 116912 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 116912 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
44235519 147661 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 147661 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232564 144884 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 144884 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727288 116887 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 116887 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44235291 151387 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151387 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44233041 144730 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
CHEMBL3912947 144730 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
138107701 186871 39 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186871 39 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186871 39 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44219292 112077 30 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3301604 112077 30 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44235522 141976 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3890685 141976 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
44234781 141992 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3890828 141992 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233522 142284 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
CHEMBL3893059 142284 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
44235044 142319 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3893346 142319 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234027 142385 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3893909 142385 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44235289 142515 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3895137 142515 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232806 142628 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3896069 142628 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
58172125 142700 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3896580 142700 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
44234528 143027 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3899229 143027 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234532 143125 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3900038 143125 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233772 143130 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3900091 143130 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234533 143452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3902808 143452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44233523 143466 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
CHEMBL3902855 143466 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
44235040 144049 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3907754 144049 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235291 144600 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3912086 144600 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44232564 144884 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3914174 144884 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
44236219 144896 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
CHEMBL3914231 144896 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
44234780 144926 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3914443 144926 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44233776 144930 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3914495 144930 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233282 145039 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3915367 145039 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
44236220 145261 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3917017 145261 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
58172129 145297 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3917222 145297 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233775 145301 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
CHEMBL3917276 145301 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
44234028 145327 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
CHEMBL3917503 145327 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
44236217 145423 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3918258 145423 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44219292 145543 30 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3919269 145543 30 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44234029 145674 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3920236 145674 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44232567 145787 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3921158 145787 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44235983 145833 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3921534 145833 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234032 145893 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3922000 145893 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44233042 145990 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3922686 145990 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44235289 146124 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3923745 146124 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233520 146285 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
CHEMBL3924965 146285 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
58172126 146352 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
CHEMBL3925563 146352 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
44235521 146411 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3926078 146411 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
58172128 146456 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
CHEMBL3926491 146456 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
44233280 146470 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3926604 146470 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
44235984 146719 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
CHEMBL3928658 146719 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
44234782 146727 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3928729 146727 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235044 147040 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3930990 147040 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234284 147149 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
CHEMBL3931899 147149 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
44235290 147310 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
CHEMBL3933131 147310 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
44234032 147380 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3933704 147380 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44232808 147459 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3934336 147459 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44234026 147494 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3934619 147494 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44235519 147661 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3935924 147661 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
58172127 147668 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
CHEMBL3935961 147668 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
44233038 147796 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3937089 147796 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44233283 147960 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
CHEMBL3938313 147960 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
44233777 148004 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3938716 148004 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232804 148147 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
CHEMBL3939932 148147 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
44233518 148284 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
CHEMBL3941036 148284 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
44235519 148494 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3942683 148494 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235043 148533 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
CHEMBL3943011 148533 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
44234530 148561 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
CHEMBL3943161 148561 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
44232568 148648 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3943791 148648 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
44234529 148881 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3945849 148881 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44234532 149680 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3952237 149680 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233774 149691 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3952293 149691 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233521 149709 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
CHEMBL3952439 149709 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
44235042 149726 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
CHEMBL3952569 149726 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
44232569 149863 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3953739 149863 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
44233279 150124 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
CHEMBL3955699 150124 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
44233039 150351 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3957516 150351 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44232805 150384 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3957760 150384 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
44235979 150541 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3959044 150541 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44233040 150703 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
CHEMBL3960203 150703 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
44233281 150825 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
CHEMBL3961361 150825 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
44235756 150874 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3961761 150874 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44233773 150882 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
CHEMBL3961809 150882 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
44235041 151215 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3964788 151215 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235291 151387 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3966307 151387 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44235039 151393 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
CHEMBL3966331 151393 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
44236216 151610 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3968156 151610 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44234783 151685 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
CHEMBL3968835 151685 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
44235982 151720 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3969137 151720 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44232566 151899 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
CHEMBL3970829 151899 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
44235520 152413 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3975122 152413 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44234528 152440 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3975263 152440 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234283 152448 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
CHEMBL3975307 152448 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
44232807 152557 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
CHEMBL3976286 152557 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
44233519 152691 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
CHEMBL3977415 152691 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
44236218 152708 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3977559 152708 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
44234779 152733 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
CHEMBL3977761 152733 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
44235980 152878 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
CHEMBL3979096 152878 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
44233043 153068 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
CHEMBL3980758 153068 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
44234782 153143 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3981383 153143 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235981 153159 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3981484 153159 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44235755 153162 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3981509 153162 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
44232803 153248 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
CHEMBL3982288 153248 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
44233278 153359 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
CHEMBL3983200 153359 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
44232565 153426 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3983767 153426 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
44235754 153452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3984010 153452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44234278 153474 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3984207 153474 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
44235753 153633 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
CHEMBL3985726 153633 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
118727297 116896 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 116896 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727311 116910 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 116910 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 116914 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 116914 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 3509 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3509 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3509 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3509 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3509 72 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44234532 149680 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 149680 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727285 116884 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 116884 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
5852 2569 47 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 2569 47 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 2569 47 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44232568 148648 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 148648 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727293 116892 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 116892 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 116894 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 116894 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
58172125 142700 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3896580 142700 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44304181 201573 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 201573 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
127052614 139683 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3805176 139683 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727310 116909 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 116909 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727301 116900 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 116900 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727304 116903 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 116903 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5283086 201610 19 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
CHEMBL64804 201610 19 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
118727314 116913 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 116913 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727286 116885 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398207 116885 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235291 151387 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151387 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44232568 148648 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 148648 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727299 116898 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 116898 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 147380 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147380 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
56839536 142625 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
CHEMBL3896035 142625 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
44235044 142319 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142319 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44235521 146411 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146411 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235519 147661 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 147661 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727287 116886 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 116886 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232564 144884 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 144884 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727314 116913 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 116913 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
1883 3021 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
1916 3021 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
5280360 3021 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
913 3021 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
CHEMBL548 3021 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
DB00917 3021 71 None -54 10 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
118727291 116890 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 116890 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
118727290 116889 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 116889 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234532 149680 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 149680 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727291 116890 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 116890 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44303980 167500 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL432522 167500 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
118727288 116887 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 116887 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 116908 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 116908 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727307 116906 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 116906 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44235522 141976 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 141976 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727289 116888 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 116888 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 116911 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 116911 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727308 116907 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 116907 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235521 146411 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146411 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44233521 149709 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952439 149709 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727303 116902 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 116902 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727306 116905 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 116905 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44219292 145543 30 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 145543 30 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
69753740 139679 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
CHEMBL3805134 139679 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
44234782 146727 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 146727 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
44234532 143125 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143125 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118352160 138886 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793892 138886 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44236221 147174 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3932106 147174 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44236221 147174 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147174 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
118727298 116897 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 116897 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
44219292 112077 30 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112077 30 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
118352285 138926 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3794226 138926 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44235520 152413 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152413 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234532 143125 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143125 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
56649302 152122 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3972583 152122 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
44235520 146728 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3928737 146728 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44219292 145543 30 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 145543 30 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 145893 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 145893 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727315 116914 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 116914 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 3509 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3509 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3509 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3509 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3509 72 None 1 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44235520 152413 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152413 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727287 116886 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 116886 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727290 116889 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 116889 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727303 116902 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 116902 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44234531 150873 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3961754 150873 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
118727300 116899 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 116899 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 145893 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 145893 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727300 116899 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 116899 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44235755 153162 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153162 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 116901 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 116901 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232565 153426 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153426 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727316 116915 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 116915 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
118727310 116909 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 116909 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029402 138815 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793009 138815 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727294 116893 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 116893 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44219292 112077 30 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112077 30 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 147380 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147380 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727313 116912 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 116912 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
118727304 116903 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 116903 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839342 148463 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3942394 148463 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
118727299 116898 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 116898 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
118727289 116888 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 116888 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234028 145327 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 145327 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
56839343 143735 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
CHEMBL3904989 143735 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
118727285 116884 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 116884 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
24901445 86804 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 86804 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416266 14516 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206115 14516 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL212943 14516 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44416264 14672 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207438 14672 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL405770 14672 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10028418 14488 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14488 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14488 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901438 86260 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 86260 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10694649 13441 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
CHEMBL119397 13441 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
10671942 103726 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
CHEMBL309835 103726 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
16664733 154277 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 154277 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
24901440 86547 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 86547 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901439 86345 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 86345 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901443 86761 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 86761 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10717385 167936 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
CHEMBL435382 167936 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
24901449 153052 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 153052 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901451 153886 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 153886 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
10529683 163081 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
CHEMBL420404 163081 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
24901441 145552 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 145552 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 86245 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 86245 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
44416281 14517 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206120 14517 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL215442 14517 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10553794 163075 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
CHEMBL420398 163075 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
24901447 86857 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 86857 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 12709 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12709 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12709 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10623568 203607 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
CHEMBL79511 203607 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
24901442 86598 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 86598 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416279 14634 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207258 14634 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL379203 14634 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9825740 14489 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205678 14489 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132649 14489 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
44416294 14700 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207781 14700 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL438092 14700 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10601359 103808 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
CHEMBL309987 103808 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
10028418 14488 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14488 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14488 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901437 87618 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 87618 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 12709 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12709 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12709 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901446 154278 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 154278 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10813802 13662 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
CHEMBL119550 13662 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
24901448 86500 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 86500 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901444 86762 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 86762 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
10502610 163155 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
CHEMBL420507 163155 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
19358473 14639 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207287 14639 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL386580 14639 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44377464 119567 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
CHEMBL350832 119567 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
10402929 57224 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
CHEMBL166351 57224 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
10204312 3284 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 3284 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
1969 796 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1969 796 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
9839644 796 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 796 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
CHEMBL9540 796 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 796 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
138 3020 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3020 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3020 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3020 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3020 84 None -16 9 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138107701 186871 39 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 186871 39 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 186871 39 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 3781 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
5820 3781 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
6918140 3781 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
CHEMBL1237119 3781 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
DB00374 3781 55 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
138107701 186871 39 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 186871 39 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 186871 39 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
2720 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
5820 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
6918140 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
CHEMBL1237119 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
DB00374 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 3781 55 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
11743147 580 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
5851 580 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
1883 3021 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3021 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3021 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3021 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3021 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3021 71 None -54 10 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
69658829 215951 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
5853 1532 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
73755162 1532 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
127861 686 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1963 686 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
CHEMBL125569 686 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1962 302 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
5311226 302 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
1968 3685 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
5311243 3685 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
CHEMBL2104890 3685 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
1965 3703 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
73755022 3703 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
1987175 3723 24 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
9283 3723 24 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
CHEMBL1372836 3723 24 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
10204312 3284 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
10204312 3284 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040
4042 3284 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
4042 3284 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040


Get vendors


Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
9955130 9399 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11211 9399 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
138107701 186871 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
5311181 186871 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
CHEMBL494 186871 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
138107701 186871 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
5311181 186871 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
CHEMBL494 186871 39 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
127029421 138777 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3792615 138777 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
86277844 111421 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
CHEMBL3287898 111421 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
44235520 152413 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 152413 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
24901449 153052 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 153052 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901439 86345 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 86345 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 86245 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 86245 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
155544367 172792 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
CHEMBL4527708 172792 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
58602756 138888 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793903 138888 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
138107701 186871 39 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
5311181 186871 39 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
CHEMBL494 186871 39 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
127029417 138892 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 138892 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
138 3020 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
1882 3020 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
5280723 3020 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
CHEMBL495 3020 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
DB00770 3020 84 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
44235522 141976 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 141976 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
11296282 1377 22 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
5822 1377 22 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
CHEMBL565591 1377 22 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
9847589 96749 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268477 96749 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
10095633 161669 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL416334 161669 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
131814 12272 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL118567 12272 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
10090048 168839 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL442405 168839 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
44219292 145543 30 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 145543 30 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 186871 39 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 186871 39 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 186871 39 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
44234032 147380 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147380 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
15236833 10901 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11746 10901 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
44157014 192007 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL521609 192007 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
44235755 153162 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 153162 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727303 116902 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 116902 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
23355418 6608 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL10836 6608 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44267380 9870 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11480 9870 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
127028521 138929 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3794245 138929 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
9823958 9565 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11291 9565 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
44267033 6451 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10829 6451 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235044 142319 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 142319 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727306 116905 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 116905 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44267032 96701 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268051 96701 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44267058 162656 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL418338 162656 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235521 146411 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 146411 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44234782 146727 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 146727 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727311 116910 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 116910 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029147 138967 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3793541 138967 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3794662 138967 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
44266708 4699 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
CHEMBL10404 4699 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
44267244 162141 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL417069 162141 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44234532 149680 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 149680 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
1892 734 15 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 734 15 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 734 15 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
1883 3021 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
1916 3021 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
5280360 3021 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
913 3021 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
CHEMBL548 3021 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
DB00917 3021 71 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
138107701 186871 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
5311181 186871 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
CHEMBL494 186871 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
138107701 186871 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5311181 186871 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
CHEMBL494 186871 39 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5852 2569 47 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 2569 47 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 2569 47 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727316 116915 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 116915 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
44232565 153426 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 153426 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
10477568 4794 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10442 4794 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10477567 7102 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10856 7102 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
127028838 138946 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3794451 138946 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
127029416 138878 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793824 138878 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
118727301 116900 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 116900 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 116911 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 116911 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
44159772 68035 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916708 68035 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
24901441 145552 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 145552 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901451 153886 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 153886 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
24901448 86500 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 86500 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10090958 10534 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
CHEMBL117038 10534 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
5311035 97341 27 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
CHEMBL271896 97341 27 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
44219292 112077 30 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112077 30 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
15290482 9177 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL11088 9177 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235519 147661 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 147661 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
15428700 4499 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
CHEMBL10261 4499 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
9955518 10925 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
CHEMBL11765 10925 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
44565193 176276 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL461390 176276 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
44267245 10024 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11571 10024 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901444 86762 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 86762 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44236221 147174 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 147174 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
127029420 138830 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793117 138830 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
127028839 138844 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793265 138844 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
44267196 96547 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL266622 96547 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901447 86857 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 86857 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
16664733 154277 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 154277 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44266736 5033 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10564 5033 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
24901446 154278 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 154278 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901442 86598 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 86598 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
15290515 7038 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10853 7038 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
44266758 97945 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL275493 97945 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
44234532 143125 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 143125 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
44235291 151387 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 151387 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
24901437 87618 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 87618 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44159530 68027 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916700 68027 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
11462174 3748 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
9277 3748 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
CHEMBL560993 3748 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
DB11900 3748 85 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
44627395 195187 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
CHEMBL565992 195187 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
44266768 4848 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10470 4848 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44266768 4848 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
CHEMBL10470 4848 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
5077 3509 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 3509 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 3509 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 3509 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 3509 72 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727314 116913 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 116913 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 116914 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 116914 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44190762 176296 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 176296 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
118727308 116907 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 116907 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
10320441 5360 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
CHEMBL10742 5360 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
10320441 5360 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10742 5360 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10452166 18765 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL128747 18765 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
24901440 86547 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 86547 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901438 86260 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 86260 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
127028837 138849 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793336 138849 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
24901445 86804 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 86804 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901436 87570 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234391 87570 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44266710 5357 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
CHEMBL10740 5357 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
10321522 167059 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
CHEMBL430154 167059 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
138107701 186871 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 186871 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 186871 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
15290495 97772 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL274393 97772 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
9934864 205802 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
CHEMBL94751 205802 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
9934864 205802 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
CHEMBL94751 205802 7 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
118727307 116906 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 116906 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44627515 195152 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
CHEMBL565799 195152 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
138107701 186871 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186871 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186871 39 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
127029418 138851 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793345 138851 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
24901443 86761 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 86761 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44234032 145893 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 145893 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44266775 4791 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
CHEMBL10439 4791 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
138107701 186871 39 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186871 39 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186871 39 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
11414893 205318 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9172 205318 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11230941 206592 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9936 206592 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10185382 64069 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813119 64069 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
1932 2886 4 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
5311228 2886 4 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
CHEMBL3286796 2886 4 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
9807448 201473 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
CHEMBL64246 201473 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
11771014 205614 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9367 205614 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56681885 64073 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813122 64073 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
44402824 70762 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
CHEMBL195456 70762 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
10277744 64066 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813116 64066 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10185103 14509 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL1206056 14509 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL190497 14509 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
10185103 14509 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL1206056 14509 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL190497 14509 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
11461588 4189 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10058 4189 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11402676 206623 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9953 206623 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
10299717 64071 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813120 64071 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
10300724 64083 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813275 64083 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
9939791 161357 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
CHEMBL415310 161357 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
44402710 71600 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
CHEMBL197319 71600 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
44304334 199881 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL60555 199881 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
56682059 64475 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819619 64475 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
11269563 141066 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
CHEMBL385126 141066 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
138 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
1882 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
5280723 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
CHEMBL495 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
DB00770 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
138 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
138 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
1882 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
5280723 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
CHEMBL495 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
DB00770 3020 84 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
56678560 64087 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813279 64087 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
11488860 19080 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
CHEMBL1290413 19080 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
11198334 205987 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9573 205987 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11737656 206494 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9873 206494 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56668353 64086 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813278 64086 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56665068 64478 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819622 64478 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56665068 64478 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819622 64478 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
44400189 67134 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL189378 67134 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
57391066 67885 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915864 67885 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
56675399 64470 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819614 64470 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
11260449 67873 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915677 67873 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11237257 67250 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
CHEMBL190288 67250 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
10116116 64065 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813115 64065 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
53358922 64084 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813276 64084 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
15947857 154963 8 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
CHEMBL404199 154963 8 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
10163305 64076 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813125 64076 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
11374965 68836 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL192662 68836 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
56671851 64091 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813283 64091 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9809136 106393 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL314533 106393 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
9895436 106520 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL315391 106520 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
53358921 64095 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813287 64095 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56678561 64088 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813280 64088 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
21877027 206562 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9910 206562 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10139183 67865 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915669 67865 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11220357 96883 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL269403 96883 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
11186023 205618 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9368 205618 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
53494965 64467 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1819611 64467 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
11236846 67870 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1915674 67870 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
53494965 64467 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
CHEMBL1819611 64467 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
11350967 66836 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187758 66836 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56661652 64464 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819609 64464 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56664921 64092 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813284 64092 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9938626 205096 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL90491 205096 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
56668527 64462 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819607 64462 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
11282605 67616 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL191175 67616 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44219292 112077 30 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112077 30 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 186871 39 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 186871 39 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 186871 39 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44304436 201620 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64854 201620 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56661510 64093 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813285 64093 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11336395 206035 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9604 206035 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11255468 206095 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9639 206095 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44266308 206277 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9744 206277 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460304 206694 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9998 206694 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
22024188 96899 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
CHEMBL269520 96899 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
11254374 206003 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9583 206003 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
10228100 64068 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813118 64068 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
56661509 64085 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813277 64085 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
57391065 67882 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915861 67882 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
57403305 67883 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915862 67883 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11260506 67185 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL189694 67185 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11352417 67872 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915676 67872 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
56672019 64468 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819612 64468 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
56675398 64463 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
CHEMBL1819608 64463 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
56675398 64463 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819608 64463 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
10116114 125352 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL364841 125352 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10116114 125352 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
CHEMBL364841 125352 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
10116114 125352 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
CHEMBL364841 125352 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
11278428 205951 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9552 205951 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11208785 205673 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9398 205673 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
11461526 205961 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9558 205961 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460765 97894 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275233 97894 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
11324024 205750 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9442 205750 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
138107701 186871 39 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 186871 39 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 186871 39 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
127046072 139293 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3798917 139293 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3799044 139293 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
11597294 165612 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
CHEMBL426387 165612 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
44234028 145327 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 145327 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
11201693 67033 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188758 67033 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10225921 14630 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1207206 14630 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL363350 14630 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
11316066 66958 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188384 66958 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10300616 64080 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813272 64080 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56658143 64459 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819604 64459 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
11292620 68835 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL192661 68835 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10185612 64067 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813117 64067 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
11392403 4467 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10241 4467 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11739220 204922 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL8935 204922 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11336790 206451 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9846 206451 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11403716 4162 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10044 4162 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244046 4166 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10045 4166 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460734 206698 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9999 206698 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44234032 147380 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147380 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44304058 201478 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64254 201478 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
21893828 64096 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813288 64096 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56681899 64097 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813289 64097 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
57401554 67887 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915866 67887 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11294449 67869 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915673 67869 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
9874010 205451 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL92539 205451 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
11261579 67242 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190236 67242 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
10028418 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL1205677 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL132589 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
10028418 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL1205677 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL132589 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
10028418 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL1205677 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL132589 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
10028418 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1205677 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL132589 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
10028418 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL1205677 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL132589 14488 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11293771 67312 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL190735 67312 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56664920 64090 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813282 64090 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11201307 67533 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL191056 67533 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11750835 67095 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL189063 67095 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
11454655 67416 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190840 67416 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11519006 102000 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL2373410 102000 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL3040272 102000 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
138107701 186871 39 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
5311181 186871 39 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
CHEMBL494 186871 39 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
138107701 186871 39 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
5311181 186871 39 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
CHEMBL494 186871 39 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
10028418 14488 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 14488 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 14488 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9955802 68827 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL192613 68827 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11404217 97654 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL273530 97654 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11473193 97883 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275124 97883 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11381211 205998 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9580 205998 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
11370857 206115 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9648 206115 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11267409 206118 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9649 206118 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
11174065 206488 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9868 206488 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11224239 64458 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819603 64458 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11224239 64458 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819603 64458 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
3356 2239 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
4326 2239 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
9867642 2239 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
CHEMBL426559 2239 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
DB11629 2239 68 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
11166017 66788 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187544 66788 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44234032 147380 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 147380 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
138107701 186871 39 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 186871 39 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 186871 39 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
11743212 16967 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
CHEMBL125588 16967 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
10227894 64074 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813123 64074 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
10181606 204618 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
CHEMBL87371 204618 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
44304388 201453 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL64187 201453 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
11282319 67307 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
CHEMBL190708 67307 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
44219292 112077 30 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 112077 30 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
10139047 12709 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 12709 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 12709 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
11318288 67594 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
CHEMBL191118 67594 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
11186079 4131 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10024 4131 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11175906 205626 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9371 205626 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11243628 206510 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9883 206510 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11391560 167171 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL430286 167171 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244380 206067 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9626 206067 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
5855 1607 4 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
9911469 1607 4 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
CHEMBL196779 1607 4 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
11407826 123116 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL361939 123116 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44326793 14470 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL1205415 14470 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL94694 14470 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
13231966 100471 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL294108 100471 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
1892 734 15 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 734 15 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 734 15 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
44304181 201573 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 201573 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
13231966 100471 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL294108 100471 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56675229 64075 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813124 64075 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
10278907 64072 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813121 64072 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
44304474 201233 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL62868 201233 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
56681898 64089 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813281 64089 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56678559 64082 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813274 64082 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
9934864 205802 7 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
CHEMBL94751 205802 7 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
10117702 64081 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813273 64081 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
127029417 138892 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 138892 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
10501053 1550 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
8314 1550 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
CHEMBL3137314 1550 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
1968 3685 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
5311243 3685 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
CHEMBL2104890 3685 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
1917 912 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 912 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 912 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 912 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
119461 317 66 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
1896 317 66 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
CHEMBL1317823 317 66 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
119304 739 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1878 739 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
40481312 739 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
CHEMBL575504 739 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1940 1625 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
3417 1625 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
5311100 1625 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
CHEMBL1201379 1625 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
DB11519 1625 38 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
1551 2245 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 2245 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 2245 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 2245 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 2245 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1913 2419 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
5311223 2419 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
1817 2496 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1936 2496 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
5282381 2496 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
CHEMBL606 2496 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
DB00929 2496 60 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1881 3018 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1891 3018 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
448457 3018 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL1235252 3018 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB02056 3018 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1883 3021 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 3021 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 3021 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3021 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3021 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 3021 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3021 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3021 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 3021 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3021 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3021 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 3021 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3021 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3021 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 3021 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3021 71 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3021 71 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 3021 71 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1884 3022 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 3022 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 3022 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3022 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3022 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 3022 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3022 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3022 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 3022 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3022 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3022 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 3022 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3022 46 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3022 46 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 3022 46 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1980 3592 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1985 3592 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
6437074 3592 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1888 3825 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1974 3825 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311493 3825 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
CHEMBL521784 3825 26 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311035 97341 27 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
CHEMBL271896 97341 27 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
1973 201781 12 3H-ILOPROST -3 37 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 201781 12 3H-ILOPROST -3 37 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 201781 12 3H-ILOPROST -3 37 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
134689669 214269 0 3H-ILOPROST -5495 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
91798918 214282 0 3H-ILOPROST -1479 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 400 10 2 6 2.6 COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
67861203 214284 0 3H-ILOPROST -21379 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 424 11 4 5 3.2 C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O None
132748 214655 0 3H-ILOPROST -7 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 3 2 4 4.6 C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl None
None 214657 0 3H-ILOPROST -10 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 477 11 1 5 5.1 C1CC(=O)CC1CCC(=CCC(C(=O)O)N2CCOCC2)OCC3=CC=C(C=C3)C4=CC=CC=C4 None
None 214699 0 Functional -19 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 214699 0 3H-PGI2 -19 3 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 214703 0 3H-PGI2 1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
None 214703 0 3H-PGI2 -1 2 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
89077401 214263 0 3H-ILOPROST -1 12 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
89077401 214263 0 3H-ILOPROST -1 12 Mouse 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 214264 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214264 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 3020 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138 3020 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3020 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3020 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3020 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3020 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3020 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3020 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3020 84 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3020 84 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 214265 0 3H-ILOPROST 2 3 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 11 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O None
None 214266 0 3H-ILOPROST 6 2 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 398 8 3 4 3.3 CC#CCC(C)C(C=CC1C(CC2C1C3=C(O2)C(=CC=C3)CCCC(=O)O)O)O None
133126726 214264 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 214264 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214264 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214264 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
1917 912 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 912 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 912 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 912 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
None 214656 0 3H-ILOPROST -7079 6 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 384 9 3 3 4.3 C1CCC(CC1)C(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O None
133126726 214264 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214264 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 3020 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3020 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3020 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3020 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3020 84 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 214267 0 3H-ILOPROST 15 2 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 442 9 1 5 5.1 CC1=C(C2=C(CC1)C(=CC=C2)OCC(=O)O)CCON=C(C3=CC=CC=C3)C4=CN=CC=C4 None
3356 2239 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
4326 2239 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
9867642 2239 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
CHEMBL426559 2239 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
DB11629 2239 68 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
5077 3509 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 3509 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 3509 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 3509 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 3509 72 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
138 3020 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 3020 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 3020 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 3020 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 3020 84 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5077 3509 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 3509 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 3509 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 3509 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 3509 72 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
69658829 215951 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
1917 912 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 912 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 912 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 912 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
133126726 214264 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 214264 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
69658829 215951 0 None -1 4 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
None 214702 0 3H-PGI2 1 2 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
None 214702 0 3H-PGI2 -1 2 Mouse 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
1917 912 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 912 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 912 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 912 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
138107701 186871 39 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 186871 39 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 186871 39 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5077 3509 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 3509 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 3509 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 3509 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 3509 72 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5077 3509 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 3509 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 3509 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 3509 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 3509 72 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
138 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
138 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
1882 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
1882 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5280723 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
5280723 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
CHEMBL495 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
CHEMBL495 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
DB00770 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
DB00770 3020 84 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5852 2569 47 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 2569 47 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 2569 47 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
10204312 3284 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 3284 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
10141039 1649 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
5854 1649 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
1967 594 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 594 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
2720 3781 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 3781 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 3781 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 3781 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 3781 55 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5852 2569 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5852 2569 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
9931891 2569 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 2569 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
CHEMBL239226 2569 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 2569 47 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
1967 594 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 594 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
1895 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
1895 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
6435378 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
6435378 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
CHEMBL236025 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
CHEMBL236025 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
DB01088 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
DB01088 1968 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
1967 594 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
5282428 594 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
1917 912 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
5311044 912 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
631 912 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
CHEMBL160629 912 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
1034 3024 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
1915 3024 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5282411 3024 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
CHEMBL1139 3024 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
DB01240 3024 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5855 1607 4 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
9911469 1607 4 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
CHEMBL196779 1607 4 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
1969 796 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 796 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 796 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1888 3825 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1974 3825 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
5311493 3825 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
CHEMBL521784 3825 26 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1892 734 15 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
25886893 734 15 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
CHEMBL1628262 734 15 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
1893 781 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
5311242 781 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
CHEMBL148319 781 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
1893 781 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
5311242 781 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
CHEMBL148319 781 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
1964 2873 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
6536812 2873 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
CHEMBL188539 2873 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
138 3020 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1882 3020 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
5280723 3020 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
CHEMBL495 3020 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
DB00770 3020 84 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1934 2051 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
5311244 2051 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
CHEMBL4522827 2051 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
1917 912 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
5311044 912 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
631 912 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
CHEMBL160629 912 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
1895 1968 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
6435378 1968 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
CHEMBL236025 1968 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
DB01088 1968 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928